NOVEL ISOTHIAZOLO-BASED BICYCLES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES AND/OR PLANT GROWTH REGULATORS

Abstract

The invention relates to the technical field of herbicides and/or plant growth regulators. Specifically, the invention relates to novelisothiazolo-based bicycles, and compositions comprising said novelisothiazolo-based bicycles. Further, the present invention relates to processes for the preparation said novel isothiazolo-based bicycles and their use as herbicides and/or plant growth regulators.

Claims

1. A compound of formulae (G1), (G2), (G3) and/or a salt thereof ##STR00037## wherein A is CR.sup.6R.sup.7, R.sup.1 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, NR.sup.13R.sup.14, R.sup.13R.sup.14N(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkoxy, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkoxy, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, aryloxy, heteroaryloxy, heterocyclyloxy, a bicyclic or a heterobicyclic residue, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, oxo, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, R.sup.2, R.sup.3 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.2-C.sub.8)-alkenyloxycarbonyl, (C.sub.2-C.sub.8)-alkynyloxycarbonyl, (C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, (C.sub.2-C.sub.8)-alkynylcarbonyl, (C.sub.1-C.sub.8)R.sup.13R.sup.14N-carbonyl, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylthiocarbonyl, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, (C.sub.2-C.sub.8)-alkynylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonylcarbonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylcarbonyloxy, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, arylcarbonyl, aryl-(C.sub.1-C.sub.8)-alkylcarbonyl, heteroarylcarbonyl, heteroaryl-(C.sub.1-C.sub.8)-alkylcarbonyl, heterocyclylcarbonyl, or heterocyclyl-(C.sub.1-C.sub.8)-alkylcarbonyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, oxo, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl, and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or NR.sup.2R.sup.3 is NCR.sup.8R.sup.9 or NS(O).sub.nR.sup.10R.sup.11, R.sup.4 is hydrogen, cyano, halogen, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkenyl or (C.sub.2-C.sub.8)-alkynyl, R.sup.5 is hydrogen, cyano, halogen, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkenyl or (C.sub.2-C.sub.8)-alkynyl, R.sup.6, R.sup.7 are each independently hydrogen, cyano, halogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, or (C.sub.3-C.sub.8)-cycloalkyl, or R.sup.6 and R.sup.7, together with the carbon atom to which they are attached, form a 3-6-membered carbocyclic or heterocyclic ring, which comprises in each case, in addition to the carbon atoms, p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n and wherein said ring is unsubstituted or is substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl and has q oxo groups, R.sup.8, R.sup.9 are each independently hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.2-C.sub.6)-alkenyloxy, (C.sub.2-C.sub.6)-(C.sub.2-C.sub.6)-alkynyloxy, NR.sup.13R.sup.14, (C.sub.1-C.sub.6)-alkoxy-(C.sub.1-C.sub.3)-alkyl, (C.sub.1-C.sub.6)-alkoxy-(C.sub.2-C.sub.6)-alkoxy-(C.sub.1-C.sub.3)-alkyl, (C.sub.1-C.sub.4)-alkylthio-(C.sub.1-C.sub.3)-alkyl, (C.sub.1-C.sub.4)-alkylsulphinyl-(C.sub.1-C.sub.3)-alkyl, (C.sub.1-C.sub.4)-alkylsulphonyl-(C.sub.1-C.sub.3)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.6)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl, heterocyclyl-(C.sub.1-C.sub.8)-alkyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.4)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl and has q oxo groups, or R.sup.8 and R.sup.9, together with the carbon atom to which they are attached, form a 3- to 8-membered unsaturated, partially saturated or saturated ring, which comprises in each case, in addition to the carbon atoms, p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n and wherein said ring is unsubstituted or is substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl and has q oxo groups, R.sup.10, R.sup.11 are each independently (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkoxy-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylthio-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphinyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylsulphonyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, aryl, aryl-(C.sub.1-C.sub.8)-alkyl, heteroaryl, heteroaryl-(C.sub.1-C.sub.8)-alkyl, heterocyclyl or heterocyclyl-(C.sub.1-C.sub.8)-alkyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or R.sup.10 and R.sup.11, together with the sulphur atom to which they are attached, form a 3- to 8-membered unsaturated, partially saturated or saturated ring, which comprises in each case, in addition to the carbon atoms and in addition to the sulphur atom, p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n and wherein said ring is unsubstituted or is substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NR.sup.13R.sup.14, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.4)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl, R.sup.13R.sup.14N-carbonyl and has q oxo groups, R.sup.12 is hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-haloalkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-haloalkynyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-halocycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkylcarbonyl or (C.sub.1-C.sub.8)-haloalkylcarbonyl, R.sup.13, R.sup.14 are each independently hydrogen, (C.sub.1-C.sub.8)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.2-C.sub.8)-alkenylcarbonyl, (C.sub.2-C.sub.8)-alkynylcarbonyl, (C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkenyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenylcarbonyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkylcarbonyl, (C.sub.3-C.sub.8)-cycloalkenyl-(C.sub.1-C.sub.8)-alkylcarbonyl, aryl, arylcarbonyl, arylsulphonyl, hetaryl, hetarylcarbonyl, hetarylsulphonyl, heterocyclyl, heterocyclylcarbonyl, heterocyclylsulphonyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NH.sub.2, (C.sub.1-C.sub.8)-alkylamine, (C.sub.1-C.sub.8)-dialkylamine, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl and wherein heterocyclyl has q oxo groups, and wherein each of the aforementioned heterocyclic residues, in addition to the carbon atoms, has in each case p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n, or R.sup.13 and R.sup.14, together with the nitrogen atom to which they are attached, form a 3-to 8-membered unsaturated, partially saturated or saturated ring, which comprises in each case, in addition to the carbon atoms and in addition to the nitrogen atom, p ring members from the group consisting of N(R.sup.12).sub.m, O and S(O).sub.n and wherein said ring is unsubstituted or is substituted by one or more residues from the group consisting of halogen, nitro, hydroxyl, cyano, NH.sub.2, (C.sub.1-C.sub.8)-alkylamine, (C.sub.1-C.sub.8)-dialkylamine, (C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-haloalkyl, (C.sub.1-C.sub.8)-alkoxy, (C.sub.1-C.sub.8)-haloalkoxy, (C.sub.1-C.sub.8)-alkylthio, (C.sub.1-C.sub.8)-alkylsulphinyl, (C.sub.1-C.sub.8)-alkylsulphonyl, (C.sub.1-C.sub.8)-haloalkylthio, (C.sub.1-C.sub.8)-haloalkylsulphinyl, (C.sub.1-C.sub.8)-haloalkylsulphonyl, (C.sub.1-C.sub.8)-alkoxycarbonyl, (C.sub.1-C.sub.8)-haloalkoxycarbonyl, (C.sub.1-C.sub.8)-alkylcarboxy, (C.sub.3-C.sub.8)-cycloalkyl, (C.sub.3-C.sub.8)-cycloalkyl-(C.sub.1-C.sub.8)-alkyl, (C.sub.1-C.sub.8)-alkoxycarbonyl-(C.sub.1-C.sub.8)-alkyl, hydroxycarbonyl, hydroxycarbonyl-(C.sub.1-C.sub.8)-alkyl and has q oxo groups, n is independently selected from 0, 1 or 2, m is independently selected from 0 or 1, p is independently selected from 0, 1, 2 or 3, q is independently selected from 0, 1 or 2, y is 0 or 1.

2. A compound of formulae (G1), (G2), (G3) and/or a salt thereof according to claim 1 wherein A is CR.sup.6R.sup.7, R.sup.1 is hydrogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.8)-alkenyl, (C.sub.2-C.sub.8)-alkynyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.3-C.sub.7)-cycloalkyl, (C.sub.3-C.sub.7)-cycloalkenyl pyridinyl, furanyl, thienyl, oxanyl or phenyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, oxo, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.6)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, (C.sub.1-C.sub.6)-haloalkoxy, R.sup.2, R.sup.3 are each independently hydrogen, pyridinylcarbonyl, furanylcarbonyl, thienylcarbonyl, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, (C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.2-C.sub.6)-alkynylcarbonyl, (C.sub.1-C.sub.6)-alkenylcarbonyl (C.sub.1-C.sub.6)-alkoxycarbonyl, (C.sub.3-C.sub.8)-cycloalkylcarbonyl, phenyl-(C.sub.1-C.sub.6)-alkylcarbonyl, (C.sub.1-C.sub.6)-alkylcarbonyloxy wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, oxo, (C.sub.1-C.sub.6)-alkyl, (C.sub.1-C.sub.4)-haloalkyl, (C.sub.1-C.sub.6)-alkoxy, R.sup.4 is hydrogen or halogen, R.sup.5 is hydrogen or (C.sub.1-C.sub.6)-alkyl, R.sup.6, R.sup.7 are each independently hydrogen, cyano, halogen, (C.sub.1-C.sub.6)-alkyl, (C.sub.2-C.sub.6)-alkenyl, (C.sub.2-C.sub.6)-alkynyl, or (C.sub.3-C.sub.8)-cycloalkyl, y is 0 or 1, 2.

3. A compound of formulae (G1), (G2), (G3) and/or a salt thereof according to claim 1 wherein A is CR.sup.6R.sup.7, R.sup.1 is H, cyclopropyl, cyclobutyl, cyclopentyl cyclohexyl, cycloheptyl, pyridinyl, cyclohexenyl, oxanyl or phenyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, R.sup.3 is hydrogen R.sup.2 is hydrogen, pyridinylcarbonyl, (C.sub.1-C.sub.4)-alkylcarbonyl, (C.sub.2-C.sub.4)-alkynyl, (C.sub.2-C.sub.4)-alkynylcarbonyl, (C.sub.1-C.sub.4)-alkoxycarbonyl, (C.sub.3-C.sub.6)-cycloalkylcarbonyl, acetyl, benzoyl, wherein all these residues are unsubstituted or substituted by one or more residues from the group consisting of halogen, oxo, (C.sub.1-C.sub.4)-alkyl, (C.sub.1-C.sub.4)-haloalkyl, (C.sub.1-C.sub.4)-alkoxy, R.sup.4 is hydrogen or halogen, R.sup.5 is hydrogen or methyl, R.sup.6 is hydrogen, R.sup.7 is hydrogen or methyl, y is 0 or 1, 2.

4. An herbicidal and/or plant growth-regulating composition, wherein said composition comprises one or more compounds of formulae (G1), (G2), (G3) and/or salts thereof as defined in claim 1, and one or more further substances selected from groups (i) and/or (ii): (i) one or more further agrochemically active substances, optionally selected from the group consisting of insecticides, acaricides, nematicides, further herbicides, fungicides, safeners, fertilizers and/or further growth regulators, (ii) one or more formulation auxiliaries customary in crop protection.

5. A product comprising a compound of formulae (G1), (G2), (G3) and/or a salt thereof according to claim 1 or a composition thereof for controlling one or more harmful plants and/or for regulating the growth of one or more plants.

6. A product comprising a compound of formulae (G1), (G2), (G3) and/or a salt thereof according to claim 1 or a composition thereof for controlling fungi.

7. A method for controlling fungi, one or more harmful plants or for regulating the growth of one or more plants, comprising applying an effective amount of one or more compounds of formulae (G1), (G2), (G3) and/or salts thereof, as defined in claim 1, or a composition thereof, to the plants, seeds of plants, soil in which or on which the plants grow or an area under cultivation.

Description

EXAMPLES

[0341] In an exemplary manner, some synthesis examples of compounds of the general formula (G) are described below. In the examples, the amounts (including percentages) refer to the weight, unless especially stated otherwise.

[0342] The symbols > and < mean greater than and smaller than, respectively. The symbol > means greater than or equal to, the symbol < means smaller than or equal to.

[0343] If, in the context of the description and the examples, the terms R and S are given for the absolute configuration on a centre of chirality of the stereoisomers of the formula (G), this RS nomenclature follows, unless defined differently, the Cahn-Ingold-Prelog rule.

[0344] In the context of the present invention and in the Tables 1 to 3 mentioning specific and preferred compounds according to the present invention, the following abbreviations are used: [0345] H=hydrogen [0346] Me=methyl or CH.sub.3 [0347] Et=ethyl [0348] Pr=propyl [0349] Bu=butyl [0350] nAlkyl=n-alkyl, e.g. nPr=n-propyl [0351] cAlkyl=cycloalkyl, e.g. cPr=cyclopropyl, cHexyl=cyclohexyl [0352] iAlkyl=isooalkyl, e.g. iPr=isopropyl [0353] tAlkyl=tertiary alkyl, e.g. tBu=tert-butyl [0354] Ac=acetyl [0355] F, Cl, Br, I=fluorine, chlorine, bromine and iodine, respectively, in accordance with the conventional chemical atom symbol [0356] MeO or OMe=methoxy [0357] CN=cyano [0358] NO.sub.2=nitro [0359] Ph=phenyl [0360] diHal=diHal, e.g. diF=difluoro [0361] triHal=triHal, e.g. triF=trifluoro [0362] CCH=ethinyl (CCH)

[0363] The position of a substituent, e.g. at the phenyl ring in position 2, is stated as a prefix to the symbol or the abbreviation of the radical, for example [0364] 2-Cl=2-chloro [0365] 2-Me=2-methyl

[0366] Numerations of the substituent positions for di- or trisubstituted substitution patterns are analogously stated as a prefix, for example

[0367] 2,3-Cl.sub.2=2,3-dichloro (e.g. as substitution at the phenyl ring)

[0368] 2,4-diF=2,4-difluoro (e.g. as substitution at the phenyl ring)

[0369] 2,4-F.sub.2=2,4-difluoro (e.g. as substitution at the phenyl ring)

[0370] 2,4,6-triF=2,4,6-trifluoro (e.g. as substitution at the phenyl ring)

[0371] 2-F-4-Cl=2-fluoro, 4-chloro (e.g. as substitution at the phenyl ring)

[0372] 5-F-2-Me=5-fluoro, 2-methyl (e.g. as substitution at the phenyl ring)

[0373] Other abbreviations are to be understood analogously to the examples stated above.

[0374] In addition, the customary chemical symbols and formulae apply, such as, for example, CH.sub.2 for methylene or CF.sub.3 for trifluoromethyl or OH for hydroxyl.

[0375] Correspondingly, composite meanings are defined as composed of the abbreviations mentioned, for example

[0376] 4-CF.sub.3-cHexyl=4-trifluoromethyl-cyclohexyl

[0377] Further, the following abbreviations are used:

[0378] DCM=dichloromethane

[0379] DMF=dimethylformamide

[0380] DMSO=dimethylsulfoxide

[0381] T3P=propylphosphonic anhydride

[0382] THF=tetrahydrofuran

[0383] NMR-Peak lists

[0384] 1H-NMR data of selected examples are written in form of 1H-NMR-peak lists. To each signal peak are listed the -value in ppm and the signal intensity in round brackets. Between the -valuesignal intensity pairs are semicolons as delimiters.

[0385] The peak list of an example has therefore the form:

[0386] 1 (intensity1); 2 (intensity2); . . . ; i (intensityi); . . . ; n (intensityn)

[0387] Intensity of sharp signals correlates with the height of the signals in a printed example of a NMR spectrum in cm and shows the real relations of signal intensities. From broad signals several peaks or the middle of the signal and their relative intensity in comparison to the most intensive signal in the spectrum can be shown.

[0388] For calibrating chemical shift for 1H spectra, tetramethylsilane and/or the chemical shift of the solvent was used, especially in the case of spectra measured in DMSO (Dimethyl sulphoxide). Therefore in NMR peak lists, tetramethylsilane peak can occur, but not necessarily

[0389] The 1H-NMR peak lists are similar to classical 1H-NMR prints and contains therefore usually all peaks, which are listed at classical NMR-interpretation.

[0390] Additionally they can show like classical 1H-NMR prints signals of solvents, stereoisomers of the target compounds, which are also object of the invention, and/or peaks of impurities.

[0391] To show compound signals in the delta-range of solvents and/or water the usual peaks of solvents, for example peaks of DMSO in DMSO-D.sub.6 and the peak of water are shown in our 1H-NMR peak lists and have usually on average a high intensity.

[0392] The peaks of stereoisomers of the target compounds and/or peaks of impurities have usually on average a lower intensity than the peaks of target compounds (for example with a purity >90%).

[0393] Such stereoisomers and/or impurities can be typical for the specific preparation process. Therefore their peaks can help to recognize the reproduction of our preparation process via side-products-fingerprints.

[0394] An expert, who calculates the peaks of the target compounds with known methods (MestreC, ACD-simulation, but also with empirically evaluated expectation values) can isolate the peaks of the target compounds as needed optionally using additional intensity filters. This isolation would be similar to relevant peak picking at classical 1H-NMR interpretation.

[0395] Further details of NMR-data description with peak lists can be found in the publication Citation of NMR Peaklist Data within Patent Applications of the Research Disclosure Database Number 564025.

[0396] The compounds according to the present invention, such as described in the Tables 1 to 3, are obtained according to or analogously to the following chemical synthesis examples.

(A) Chemical Synthesis Examples

1. Synthesis of 3-amino-6-[(4-fluorophenyl)methyl]isothiazolo[4,5-d]pyrimidin-7-one (compound No. I-14) and 3-amino-6-(cycloheptylmethyl)-4,5-dihydroisothiazolo[4,5-d]pyrimidin-7-one (compound No. I-59)

[0397] The following scheme illustrates the steps (i) to (vi) with general procedures for steps 1.1 to 1.4 and detailed examples for steps 1.5 and 1.6:

##STR00035##

1.1 Step (i)=General Procedure

[0398] To a stirred solution of ester 1 (1.0 mmol) in DMF (1.9 mL per mmol) was added formamidine acetate (5 mmol). The reaction mixture was then stirred at 120 C. for 18 h. The mixture was quenched by addition of iced water and the resulting precipitate was collected by filtration and dried at air to yield compound 2.

1.2 Step (ii)=General Procedure

[0399] To a stirred solution of pyrimidinone 2 (1.0 mmol) in DMF (6.3 mL per mmol) was successively added the desired alkyl bromide (1.2 mmol), cesium carbonate (1.5 mmol) and potassium iodide (0.1 mmol). The reaction mixture was then stirred at 120 C. for 3 h and then cooled to rt. The mixture was quenched by addition of iced water and the aqueous phase extracted three times with EtOAc. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered, concentrated and purified by column chromatography to yield compound 3.

1.3 Step (iii)=General Procedure

[0400] To a stirred solution of ester 3 (1.0 mmol) in DCM (5.5 mL per mmol) at 0 degree was added dropwise trifluoroacetic acid (5 mmol). The reaction mixture was then stirred at rt for 18 h and the solution concentrated to dryness to yield acid 4 which was engaged in the next step without further purification.

1.4 Step (iv)=General Procedure

[0401] To a stirred solution of acid 4 (1.0 mmol) in a 3:1 mixture of THF:tBuOH (12 mL per mmol) was successively added triethylamine (1.5 mmol) and diphenyl phosphoryl azide (1.2 mmol). The reaction mixture was then stirred at 70 C. for 18 h and then cooled to rt. The mixture was quenched by addition of iced water and the aqueous phase extracted three times with EtOAc. The combined organic extracts were washed with brine, dried over sodium sulfate, filtered and concentrated to yield carbamate 5. This compound was engaged in the next step without further purification.

1.5 Step (v)=Synthesis of Selected Example 3-amino-6-[(4-fluorophenyl)methyl]isothiazolo[4,5-d]pyrimidin-7-one (Example I-14)

[0402] A solution of 0.42 g of tert-butyl N-[6-[(4-fluorophenyl)methyl]-7-oxo-isothiazolo[4,5-d]pyrimidin-3-yl]carbamate (0.11 mol) in DCM (27 mL) and trifluoroacetic acid (9 mL) was stirred at rt for 18 h. The mixture was concentrated to dryness and purified by column chromatography. Yield: 46 mg (15% of theory).

[0403] .sup.1H-NMR (300 MHz, DMSO , ppm) 8.70 (s, 1H), 7.43 (dd, 2H), 7.19 (dd, 2H), 6.83 (br. s, 2H), 5.22 (s, 2H).

1.6 Step (vi)=Synthesis of Selected Example 3-amino-6-(cycloheptylmethyl)-4,5-dihydroisothiazolo[4,5-d]pyrimidin-7-one (Example I-59)

[0404] To a stirred solution of 0.13 g of 3-amino-6-(cycloheptylmethyl)isothiazolo[4,5-d]pyrimidin-7-one (0.48 mmol) in THF (6 mL) at 30 degrees was added dropwise 4.8 mL of a solution of a borane/THF complex (4.8 mmol, 1 M in THF). The reaction mixture was then stirred at 30 degrees for 18 h. The reaction mixture was then quenched by addition of MeOH and the mixture was warmed slowly to 70 degrees for 2 h and then cooled to rt. The resulting mixture was partitioned between water and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 16 mg (12% of theory).

[0405] .sup.1H-NMR (300 MHz, DMSO , ppm) 6.39 (t, 1H), 6.15 (br. s, 2H), 4.63 (d, 2H), 3.18 (d, 2H), 1.78-1.32 (m, 11H), 1.17-1.07 (m, 2H).

2. Synthesis of 3-amino-6-(cyclohexylmethyl)-4-methyl-isothiazolo[4,5-d]pyridazin-7-one (Compound No. I-75)

[0406] The following scheme illustrates the steps (i) to (v) described in detail in the examples 2.1 to 2.4:

##STR00036##

2.1 Step (i)=Synthesis of methyl 4-acetyl-3-(dimethylamino)isothiazole-5-carboxylate

[0407] To a stirred solution of 5.0 g of ester 8 (10 mmol) in THF (25 mL) at 70 degrees was added dropwise 10 mL of a THF solution of isopropylmagnesium chloride lithium chloride (13 mmol, 1.3 M). The reaction mixture was then stirred for 5 min and acetic anhydride was added dropwise. The mixture was stirred at 70 degrees for 2 h, warmed to rt and quenched by addition of a saturated aqueous solution of ammonium chloride. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography.

[0408] Yield: 1.9 g (47% of theory).

[0409] .sup.1H-NMR (400 MHz, DMSO , ppm) 3.93 (s, 3H), 1.37 (s, 18H).

2.2 Step (ii)=Synthesis of 4-acetyl-3-(dimethylamino)isothiazole-5-carboxylic Acid

[0410] To a stirred solution of 0.50 g of ester 9 (1.2 mmol) in THF (1.7 mL) and MeOH (1.7 mL) was added 0.94 mL of a 2 M aqueous solution of sodium hydroxide (1.9 mmol). The reaction mixture was then stirred at rt for 1 h. The mixture was concentrated and the residue partitioned between a 2 M aqueous solution of HCl and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered and concentrated. The corresponding acid was engaged in the next step without further purification. Yield: 0.47 g (98% of theory).

2.3 Step (iii)=Synthesis of 6-(cyclohexylmethyl)-3-(dimethylamino)-4-methyl-isothiazolo[4,5-d]pyridazin-7-one

[0411] To a stirred solution of 0.47 g of acid 10 (1.2 mmol) in THF (12 mL) was added successively 1.4 mL of T3P (2.5 mmol, 50% in THF), 0.51 mL of triethylamine (3.7 mmol) and 0.30 g of cyclohexylmethyl hydrazine (1.8 mmol). The reaction mixture was then stirred at 65 degrees for 2 days. The mixture was quenched by addition of a 2 M aqueous solution of sodium hydroxide and EtOAc. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by HPLC. Yield: 0.18 g (31% of theory).

[0412] .sup.1H-NMR (400 MHz, DMSO , ppm) 4.01 (d, 2H), 2.42 (s, 3H), 1.95-1.42 (m, 6H), 1.38 (s, 18H), 1.32-0.91 (m, 5H).

2.4 Step (iv)=Synthesis of 3-amino-6-(cyclohexylmethyl)-4-methyl-isothiazolo[4,5-d]pyridazin-7-one (Example I-75)

[0413] To a stirred solution of 0.18 g of carbamate 11 (0.38 mmol) in DCM (2.0 mL) was slowly added 0.87 mL of trifluoroacetic acid (11 mmol) and the reaction mixture was then stirred at rt for 18 h. The mixture was concentrated and the residue partitioned between EtOAc and a 2 M aqueous solution of sodium hydroxide. The aqueous phase was extracted twice with EtOAc and the combined organic extracts were dried over sodium sulfate, filtered, concentrated and purified by column chromatography. Yield: 38 mg (36% of theory).

[0414] .sup.1H-NMR (400 MHz, DMSO , ppm) 6.63 (br. s, 2H), 3.93 (d, 2H), 2.55 (s, 3H), 1.91-1.83 (m, 1H), 1.67-1.55 (m, 5H), 1.16-0.99 (m, 5H).

[0415] NMR Peak Lists

[0416] NMR peak lists for compounds according to formulae (G1), (G2) and (G3) in the context of the present invention. The numbering refers to Tables 1 to 3 above.

TABLE-US-00004 I-01: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.5081 (16.0); 6.7984 (9.3); 4.0413 (0.4); 4.0173 (0.5); 3.9859 (10.0); 3.9605 (10.2); 3.3239 (29.2); 2.5144 (11.3); 2.5086 (22.3); 2.5026 (29.4); 2.4967 (20.2); 2.3941 (0.6); 2.3719 (1.4); 2.3463 (1.9); 2.3217 (1.5); 2.2965 (0.7); 2.2726 (0.3); 1.9897 (1.6); 1.6424 (5.8); 1.6295 (5.1); 1.6138 (4.4); 1.5877 (3.2); 1.5370 (2.0); 1.5237 (2.3); 1.5068 (3.2); 1.4949 (2.5); 1.4444 (0.5); 1.2921 (2.2); 1.2705 (2.7); 1.2525 (2.5); 1.2098 (0.9); 1.1989 (0.9); 1.1750 (0.9); 1.1513 (0.5); 0.0001 (4.4) I-02: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.6901 (7.7); 7.3687 (6.9); 7.3537 (16.0); 7.3401 (1.5); 7.3276 (1.8); 7.3163 (1.6); 7.2994 (1.2); 7.2892 (0.5); 7.2819 (0.4); 6.8318 (4.5); 5.2479 (9.4); 3.3290 (3.9); 2.5155 (2.4); 2.5097 (4.8); 2.5038 (6.2); 2.4979 (4.4); 1.9906 (1.0); 1.1754 (0.6); 0.0002 (1.2) I-03: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.5212 (16.0); 6.8039 (9.7); 4.0415 (0.4); 4.0179 (0.3); 3.9043 (11.0); 3.8801 (11.2); 3.3249 (12.7); 2.5088 (17.4); 2.5030 (22.4); 2.4972 (15.8); 1.9900 (1.4); 1.3305 (0.5); 1.3215 (0.8); 1.3050 (1.5); 1.2964 (1.5); 1.2900 (1.2); 1.2794 (2.3); 1.2632 (1.5); 1.2537 (1.7); 1.2376 (1.2); 1.2139 (0.4); 1.1989 (0.5); 1.1751 (0.9); 1.1515 (0.6); 0.5431 (1.4); 0.5373 (1.3); 0.5209 (5.7); 0.5093 (3.5); 0.4994 (4.9); 0.4935 (5.1); 0.4826 (3.5); 0.4664 (1.7); 0.4579 (3.1); 0.4425 (7.3); 0.4305 (6.0); 0.4083 (1.4); 0.0002 (3.9) I-04: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.6327 (10.0); 8.6297 (9.5); 7.4150 (0.9); 7.4088 (1.0); 7.3901 (2.3); 7.3635 (2.9); 7.3575 (1.9); 7.3451 (1.6); 7.3391 (1.6); 7.3092 (1.6); 7.3037 (1.6); 7.2836 (3.8); 7.2781 (3.6); 7.2674 (3.4); 7.2643 (3.8); 7.2588 (3.1); 7.2524 (2.4); 7.2398 (2.6); 7.2292 (3.5); 7.2020 (6.0); 7.1774 (4.9); 7.1526 (2.0); 7.1488 (1.7); 6.8466 (6.2); 5.2968 (16.0); 4.0417 (0.4); 4.0180 (0.4); 3.8227 (0.8); 3.4468 (0.4); 3.4312 (0.4); 2.7252 (0.4); 2.5096 (15.6); 2.5038 (20.2); 2.4980 (14.2); 1.9904 (1.6); 1.2351 (1.6); 1.2178 (0.6); 1.1990 (0.6); 1.1943 (0.6); 1.1823 (0.5); 1.1754 (1.0); 1.1588 (0.8); 1.1515 (0.7); 1.1348 (0.4); 0.8974 (0.4); 0.8754 (0.4); 0.8595 (0.5); 0.8338 (0.4); 0.0001 (3.4) I-05: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.4950 (16.0); 6.7970 (10.2); 4.0628 (4.5); 4.0373 (5.6); 4.0116 (4.5); 3.3242 (19.5); 2.5140 (14.6); 2.5083 (27.2); 2.5025 (34.8); 2.4966 (23.9); 1.9895 (1.3); 1.7581 (3.3); 1.7140 (3.8); 1.6829 (2.7); 1.6439 (4.3); 1.6239 (5.1); 1.5998 (6.2); 1.5742 (5.5); 1.5502 (2.7); 1.3349 (0.5); 1.3116 (0.9); 1.2985 (1.2); 1.2875 (1.5); 1.2755 (2.0); 1.2647 (2.1); 1.2514 (1.8); 1.2244 (2.7); 1.1818 (4.4); 1.1511 (3.9); 1.1049 (1.0); 1.0649 (0.4); 0.9899 (1.6); 0.9523 (3.4); 0.9146 (2.7); 0.8859 (1.0); 0.0002 (6.2) I-06: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.3956 (9.5); 9.1616 (6.1); 9.1563 (6.3); 8.8363 (4.4); 8.8312 (4.6); 8.8202 (4.9); 8.8149 (4.8); 8.5077 (16.0); 8.3870 (2.4); 8.3813 (3.7); 8.3739 (2.8); 8.3605 (3.1); 8.3547 (3.9); 8.3474 (2.8); 7.6477 (3.4); 7.6316 (3.3); 7.6213 (3.4); 7.6049 (3.2); 7.2523 (0.7); 7.0820 (0.7); 6.9119 (0.7); 5.5735 (0.4); 5.5237 (0.4); 5.3871 (0.6); 5.3103 (0.6); 5.2807 (0.6); 5.2596 (0.6); 5.2413 (0.7); 5.1778 (0.8); 5.1337 (0.7); 5.0779 (0.9); 5.0410 (0.8); 4.9556 (0.7); 4.9094 (0.7); 4.8735 (0.6); 4.7032 (0.6); 4.6623 (0.4); 4.6249 (0.4); 4.5701 (0.4); 4.5397 (0.4); 4.4352 (0.4); 3.9214 (8.3); 3.8971 (8.5); 3.7278 (0.6); 2.7228 (0.7); 2.5134 (43.8); 2.5075 (86.4); 2.5016 (114.3); 2.4957 (78.0); 2.2718 (0.6); 1.8326 (1.1); 1.8070 (1.5); 1.7824 (1.2); 1.7722 (1.1); 1.7467 (0.8); 1.6943 (2.9); 1.6747 (3.7); 1.6062 (5.0); 1.5626 (3.8); 1.1650 (6.2); 1.1399 (4.4); 1.0974 (0.9); 1.0706 (1.6); 1.0232 (2.8); 0.9852 (2.1); 0.7814 (0.4); 0.0108 (0.9); 0.0001 (21.4); 1.3983 (0.4); 2.9760 (0.4) I-07: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.9883 (6.8); 8.5326 (16.0); 8.4361 (4.3); 6.7960 (2.0); 3.9154 (8.5); 3.8907 (9.7); 3.8625 (2.6); 3.4073 (0.4); 3.3427 (6.8); 2.7270 (0.5); 2.5136 (31.4); 2.5077 (61.2); 2.5018 (80.1); 2.4960 (54.7); 2.2666 (0.4); 2.1614 (0.6); 2.1383 (1.7); 2.1209 (3.1); 2.1023 (1.8); 2.0978 (1.7); 2.0756 (1.5); 1.8340 (1.1); 1.8229 (1.4); 1.8126 (1.5); 1.7991 (1.7); 1.7890 (1.6); 1.7758 (1.5); 1.7622 (1.3); 1.7518 (1.0); 1.6693 (4.5); 1.6007 (5.5); 1.5574 (4.2); 1.2337 (0.8); 1.1588 (7.4); 1.1315 (5.1); 1.0589 (1.9); 1.0222 (3.3); 0.9812 (2.6); 0.8682 (2.8); 0.8590 (8.5); 0.8441 (10.0); 0.8325 (15.7); 0.0001 (18.0); 0.0110 (0.6) I-08: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.2921 (14.8); 7.6306 (4.0); 7.6249 (4.1); 7.6012 (5.0); 7.5190 (3.7); 7.5137 (3.6); 7.4952 (5.8); 7.4893 (6.3); 7.4686 (2.4); 7.4498 (5.6); 7.4269 (8.3); 7.4068 (4.3); 7.3819 (1.3); 6.8250 (13.4); 6.2140 (1.4); 6.1910 (4.4); 6.1675 (4.4); 6.1442 (1.4); 3.3490 (9.4); 2.5071 (28.6); 1.8490 (16.0); 1.8254 (15.6); 1.2309 (0.5); 1.1953 (0.4); 1.1757 (0.3); 1.0921 (0.4); 0.8734 (0.3); 0.0000 (1.3) I-09: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.6042 (14.5); 7.5401 (3.5); 7.5349 (3.9); 7.5143 (4.3); 7.5096 (4.8); 7.3844 (1.4); 7.3786 (1.6); 7.3600 (3.6); 7.3539 (3.5); 7.3308 (4.6); 7.3060 (4.2); 7.3010 (4.0); 7.2813 (1.7); 7.2765 (1.4); 7.0814 (3.6); 7.0763 (3.4); 7.0569 (3.1); 7.0510 (2.8); 6.8651 (9.9) ; 6.0545 (1.3); 5.3180 (16.0); 3.8210 (0.6); 3.3546 (11.2); 2.5079 (26.2); 2.5022 (33.8); 2.4964 (23.8); 2.0753 (0.8); 0.0001 (5.9) I-10: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.5050 (5.8); 7.3935 (16.0); 6.7948 (4.3); 6.6992 (0.4); 6.1083 (2.9); 6.0903 (2.8); 3.4319 (1.4); 2.5013 (10.7); 1.8842 (10.4); 1.8641 (9.9); 1.2314 (0.4) I-11: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.46 (1H), 6.78 (2H), 3.93 (2H), 3.83 (2H), 3.24 (2H), 2.05-1.99 (1H), 1.49-1.45 (2H), 1.36-1.27 (2H) I-12: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.6279 (9.9); 7.4458 (1.6); 7.4169 (3.4); 7.3947 (3.4); 7.3659 (1.8); 7.3272 (2.0); 7.3188 (2.2); 7.2885 (3.4); 7.2605 (2.1); 7.2521 (2.1); 7.1029 (1.9); 7.0971 (1.9); 7.0746 (3.5); 7.0687 (3.3); 7.0462 (1.7); 7.0404 (1.6); 6.8449 (11.8); 5.4833 (0.5); 5.2617 (16.0); 4.0435 (0.4); 4.0198 (0.4); 3.3344 (3.8); 2.5708 (0.4); 2.5124 (8.4); 2.5071 (10.6); 1.9926 (1.7); 1.2008 (0.5); 1.1770 (0.9); 1.1534 (0.5); 1.0924 (0.5); 0.0001 (1.2) I-13: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.61 (1H), 7.34-7.17 (3H), 6.84 (2H), 5.27 (2H) I-14: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.7001 (9.3); 7.4454 (8.4); 7.4292 (6.2); 7.2164 (5.8); 7.1882 (9.3); 7.1604 (4.8); 6.8307 (11.0); 5.2254 (16.0); 3.3352 (16.9); 2.5057 (34.6); 0.0002 (0.8) I-15: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.5501 (0.4); 8.4966 (16.0); 6.7887 (11.6); 4.0736 (12.0); 4.0490 (12.3); 3.3238 (5.1); 2.7887 (0.9); 2.7650 (2.1); 2.7394 (2.7); 2.7144 (2.1); 2.6891 (0.8); 2.5104 (9.9); 2.5049 (12.2); 2.4996 (8.8); 1.9712 (3.7); 1.9638 (4.6); 1.9402 (4.6); 1.9250 (2.8); 1.9141 (3.3); 1.8902 (2.5); 1.8768 (2.4); 1.8561 (5.2); 1.8267 (11.6); 1.8212 (11.4); 1.8116 (8.8); 1.7878 (3.6); 1.7617 (1.7); 0.0001 (1.7) I-16: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.6887 (9.1); 7.4436 (1.4); 7.4334 (1.1); 7.4136 (16.0); 7.4072 (13.9); 7.3871 (0.9); 7.3771 (1.2); 6.8380 (6.0); 5.2322 (10.8); 3.3278 (6.5); 2.5095 (9.4); 2.5037 (12.0); 2.4979 (8.3); 2.0774 (0.5); 0.0001 (1.9) I-17: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.43 (1H), 6.78 (2H), 3.88 (2H), 1.83-1.55 (6H), 1.24-1.02 (5H) I-18: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 15.2406 (0.4); 11.3639 (0.5); 11.3421 (0.6); 11.3233 (0.7); 11.2450 (7.3); 8.5039 (14.8); 8.1495 (0.6); 8.0550 (14.3); 8.0273 (15.3); 7.9362 (0.4); 7.8077 (0.4); 7.7350 (0.7); 7.6580 (16.0); 7.6300 (13.8); 3.9185 (12.8); 3.8954 (12.7); 3.5694 (0.4); 3.4802 (0.4); 3.4166 (1.0); 3.3402 (60.6); 2.7308 (0.7); 2.7135 (0.4); 2.5038 (58.7); 2.3743 (0.4); 2.3038 (0.4); 2.2708 (0.5); 2.1156 (0.4); 2.0781 (0.4); 1.8007 (4.0); 1.6682 (9.8); 1.6038 (12.4); 1.5636 (9.5); 1.3950 (0.6); 1.3599 (0.5); 1.3115 (0.6); 1.2298 (3.2); 1.1601 (13.6); 1.1366 (10.5); 1.0517 (4.7); 1.0227 (7.2); 0.9908 (5.6); 0.9016 (0.7); 0.8562 (0.6); 0.7851 (0.4); 0.0004 (3.7) I-19: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.2404 (9.1); 8.6611 (13.1); 8.4872 (4.4); 8.4712 (4.4); 8.0636 (10.2); 8.0351 (11.7); 7.8587 (2.2); 7.8535 (2.2); 7.8331 (4.4); 7.8277 (4.2); 7.8074 (2.6); 7.8018 (2.5); 7.6700 (11.8); 7.6416 (10.3); 7.5038 (5.3); 7.4776 (4.6); 7.3468 (3.0); 7.3294 (3.4); 7.3061 (2.5); 5.4079 (16.0); 3.8040 (2.1); 3.7959 (2.2); 2.5998 (0.4); 2.5718 (0.7); 2.5022 (37.2); 2.0756 (0.4); 1.1265 (0.6); 0.0001 (3.1) I-20: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.3905 (6.3); 8.5114 (10.0); 8.0255 (13.8); 8.0192 (16.0); 7.9559 (4.6); 7.9497 (6.9); 7.9434 (3.2); 3.9195 (5.0); 3.8956 (5.2); 3.3686 (2.5); 3.2873 (0.4); 2.7332 (0.4); 2.5135 (22.5); 2.5078 (42.1); 2.5019 (54.5); 2.4960 (37.3); 2.2712 (0.4); 2.0761 (0.4); 1.8035 (1.0); 1.7782 (0.8); 1.6723 (2.4); 1.6069 (3.2); 1.5598 (2.4); 1.1945 (1.3); 1.1635 (4.0); 1.1361 (2.8); 1.0617 (1.1); 1.0230 (1.9); 0.9865 (1.4); 0.0001 (11.1) I-21: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4209 (6.4); 8.6775 (11.2); 8.4826 (3.0); 8.4685 (2.7); 8.0443 (14.5); 8.0380 (16.0); 7.9644 (4.6); 7.9582 (7.4); 7.9519 (3.4); 7.8601 (1.7); 7.8536 (1.7); 7.8340 (3.2); 7.8280 (2.8); 7.8081 (1.8); 7.8021 (1.8); 7.5060 (3.9); 7.4788 (3.2); 7.3485 (1.9); 7.3286 (2.1); 7.3071 (1.7); 5.4102 (10.8); 4.6806 (0.4); 4.6123 (0.5); 4.5291 (0.6); 4.5116 (0.6); 4.4296 (0.6); 4.3855 (0.6); 4.3578 (0.6); 4.3196 (0.6); 4.2789 (0.6); 4.2320 (0.6); 4.1870 (0.6); 4.1755 (0.5); 4.1518 (0.6); 4.1264 (0.7); 4.0749 (0.6); 4.0452 (0.5); 4.0364 (0.5); 2.9705 (0.6); 2.8791 (0.5); 2.7290 (0.8); 2.7208 (0.8); 2.5133 (55.3); 2.5075 (103.4); 2.5016 (133.4); 2.4957 (91.0); 2.4571 (0.6); 2.2754 (0.6); 2.0752 (0.5); 1.1469 (0.8); 0.0002 (22.6); 0.1987 (0.5); 1.0614 (0.4); 1.1434 (0.4) I-22: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4738 (9.0); 8.5374 (16.0); 7.8682 (3.7); 7.8421 (4.9); 7.8158 (1.2); 7.7958 (3.2); 7.7712 (3.9); 7.7500 (3.7); 7.7234 (6.5); 7.6983 (2.8); 3.9172 (8.3); 3.8930 (8.4); 3.3806 (4.4); 3.2938 (0.4); 2.7318 (0.5); 2.5136 (22.5); 2.5077 (43.4); 2.5018 (57.0); 2.4960 (39.5); 2.2731 (0.5); 2.0757 (2.1); 1.8324 (1.1); 1.8068 (1.6); 1.7831 (1.1); 1.6721 (3.9); 1.6102 (5.5); 1.5689 (3.9); 1.1930 (2.0); 1.1617 (6.2); 1.1343 (4.3); 1.0606 (1.7); 1.0223 (3.0); 0.9865 (2.3); 0.9541 (0.8); 0.0110 (0.4); 0.0002 (7.9) I-23: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.5682 (0.5); 11.5134 (2.1); 8.8554 (0.8); 8.7090 (16.0); 8.6741 (0.7); 8.4834 (3.8); 8.4672 (4.3); 8.1707 (0.6); 7.8797 (2.9); 7.8515 (6.2); 7.8446 (2.9); 7.8248 (5.3); 7.8190 (5.5); 7.7993 (4.3); 7.7932 (4.0); 7.7849 (3.7); 7.7582 (5.4); 7.7383 (4.2); 7.4982 (5.4); 7.4720 (4.4); 7.3418 (2.9); 7.3223 (3.2); 7.3173 (3.1); 7.3006 (2.7); 5.4052 (15.8); 4.7492 (0.5); 4.3840 (0.5); 4.2314 (0.5); 3.3329 (397.2); 3.2450 (0.6); 3.2281 (0.7); 3.1761 (0.5); 3.1629 (0.5); 3.0336 (0.5); 2.9414 (0.6); 2.9254 (0.7); 2.8858 (0.5); 2.7231 (1.0); 2.5852 (0.5); 2.5137 (57.6); 2.5079 (113.8); 2.5020 (150.1); 2.4962 (104.2); 2.2661 (1.0); 1.5692 (0.5); 1.2465 (1.0); 1.2257 (0.6); 1.1451 (1.0); 0.9086 (0.5); 0.0001 (22.0); 0.0113 (0.7); 3.5194 (0.5) I-24: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.3789 (9.5); 8.5395 (16.0); 7.6178 (3.1); 7.6141 (3.2); 7.5941 (4.6); 7.5884 (5.2); 7.5755 (2.5); 7.5547 (6.5); 7.5502 (10.1); 7.5279 (5.6); 7.5222 (4.2); 7.5094 (0.8); 7.5018 (2.3); 7.4957 (1.9); 7.4840 (4.0); 7.4772 (3.6); 7.4600 (4.0); 7.4539 (3.9); 7.4366 (1.6); 7.4305 (1.4); 4.3620 (0.4); 4.3382 (0.5); 4.3151 (0.7); 4.2806 (0.5); 4.2425 (0.6); 4.1699 (0.9); 4.1490 (1.0); 4.1245 (1.0); 4.1005 (0.9); 4.0818 (1.0); 4.0582 (0.9); 4.0323 (0.8); 4.0079 (0.7); 3.9638 (0.6); 3.9160 (8.5); 3.8916 (8.5); 3.8342 (0.4); 2.7280 (0.3); 2.5138 (25.1); 2.5080 (50.9); 2.5022 (68.1); 2.4963 (47.8); 2.4429 (0.3); 2.3849 (0.5); 2.2729 (0.4); 2.2667 (0.4); 2.0768 (0.5); 1.8697 (0.4); 1.8305 (1.0); 1.8071 (1.4); 1.7973 (1.3); 1.7804 (1.2); 1.7466 (0.6); 1.6732 (3.6); 1.6089 (5.2); 1.5628 (3.8); 1.3412 (0.5); 1.3179 (0.9); 1.2941 (0.4); 1.2361 (0.6); 1.1969 (1.9); 1.1901 (1.9); 1.1625 (6.0); 1.1341 (4.3); 1.0605 (1.6); 1.0203 (2.8); 0.9839 (2.2); 0.9658 (0.9); 0.9482 (0.8); 0.0679 (0.6); 0.0002 (9.9); 0.0115 (0.4) I-25: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4179 (9.0); 8.7114 (16.0); 8.6773 (0.4); 8.5022 (4.1); 8.4886 (4.2); 8.4859 (4.0); 7.8870 (2.3); 7.8812 (2.2); 7.8614 (4.5); 7.8555 (4.4); 7.8358 (2.9); 7.8299 (2.8); 7.7957 (0.4); 7.7714 (0.4); 7.6465 (3.2); 7.6426 (3.2); 7.6229 (4.5); 7.6172 (4.5); 7.5930 (1.5); 7.5873 (2.2); 7.5663 (6.4); 7.5615 (9.6); 7.5559 (4.6); 7.5385 (6.2); 7.5324 (7.4); 7.5290 (6.8); 7.5125 (3.2); 7.5055 (5.3); 7.5024 (5.6); 7.4973 (5.7); 7.4902 (3.7); 7.4726 (3.9); 7.4666 (3.8); 7.4492 (1.7); 7.4433 (1.5); 7.3755 (2.8); 7.3562 (3.0); 7.3511 (3.0); 7.3344 (2.5); 5.4165 (15.7); 2.5419 (0.7); 2.5086 (27.5); 2.5027 (35.3); 2.4969 (24.2); 1.2469 (0.4); 1.2320 (0.5); 1.2264 (0.5); 0.9090 (0.4); 0.0001 (5.0) I-26: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.0450 (6.5); 8.7115 (15.7); 8.4929 (3.7); 8.4794 (3.7); 7.8765 (2.2); 7.8706 (2.1); 7.8509 (4.3); 7.8450 (4.2); 7.8253 (2.7); 7.8193 (2.6); 7.5102 (5.0); 7.4840 (4.4); 7.3662 (2.7); 7.3468 (2.9); 7.3415 (2.8); 7.3251 (2.5); 5.4123 (16.0); 2.7112 (0.5); 2.5148 (10.7); 2.5091 (21.2); 2.5033 (28.1); 2.4974 (19.6); 2.1786 (0.6); 2.1588 (1.5); 2.1543 (1.6); 2.1469 (1.2); 2.1368 (2.8); 2.1276 (1.3); 2.1185 (1.6); 2.0955 (0.7); 0.9046 (0.4); 0.8742 (7.8); 0.8596 (9.2); 0.8473 (14.7); 0.0002 (5.5) I-27: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.4753 (5.5); 6.8105 (3.3); 3.5339 (16.0); 3.3407 (10.1); 2.5089 (13.1); 2.5031 (17.3); 2.4974 (12.2); 1.9903 (0.6); 1.1743 (0.4); 0.0001 (2.8) I-28: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.6147 (12.5); 8.4751 (3.7); 8.4610 (3.7); 7.8350 (1.8); 7.8292 (1.9); 7.8093 (3.9); 7.8037 (3.7); 7.7838 (2.3); 7.7781 (2.2); 7.4501 (4.6); 7.4241 (3.9); 7.3306 (2.6); 7.3123 (2.8); 7.3063 (2.7); 7.2895 (2.2); 6.8515 (9.6); 5.3683 (16.0); 3.3328 (7.7); 2.5659 (8.8); 2.5084 (14.5); 2.5031 (17.7); 0.0001 (2.4) I-29: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.3796 (16.0); 6.8129 (14.0); 5.4510 (5.5); 4.5313 (14.9); 3.3943 (0.4); 3.3333 (22.0); 2.5044 (30.2); 1.9536 (6.8); 1.9253 (5.7); 1.9066 (7.7); 1.5730 (5.2); 1.5510 (6.0); 1.5294 (5.6); 1.5084 (6.2); 1.4904 (5.3); 1.0913 (0.5); 0.0001 (2.4) I-30: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.3239 (14.8); 6.8139 (16.0); 4.1951 (3.5); 4.1865 (3.6); 4.1503 (5.0); 4.1413 (4.9); 4.0170 (0.4); 3.9685 (3.8); 3.9392 (4.6); 3.9234 (3.2); 3.8942 (3.4); 3.8577 (4.0); 3.8215 (4.4); 3.6128 (2.6); 3.5850 (4.0); 3.5528 (2.3); 3.4055 (0.5); 3.3388 (29.4); 3.2710 (3.6); 3.2457 (2.8); 2.7327 (0.5); 2.5040 (31.7); 2.4357 (0.4); 2.4224 (0.3); 1.9898 (0.7); 1.7797 (4.0); 1.6668 (3.6); 1.6281 (4.2); 1.5273 (1.0); 1.4525 (12.7); 1.3382 (0.7); 1.2729 (2.0); 1.2358 (3.4); 1.1981 (2.8); 1.1568 (1.1); 1.0916 (0.3); 0.8689 (0.4); 0.0001 (1.6) I-31: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 8.48 (1H), 6.79 (2H), 3.87 (2H), 2.01-1.99 (1H), 1.75-1.10 (12H) I-32: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.2253 (9.2); 8.5937 (16.0); 8.0315 (11.4); 8.0251 (4.1); 8.0090 (4.9); 8.0027 (13.2); 7.6526 (13.8); 7.6464 (4.5); 7.6240 (11.6); 7.4693 (0.4); 7.4478 (2.5); 7.4412 (4.2); 7.4141 (15.8); 7.3886 (10.7); 7.3688 (3.0); 7.3630 (4.3); 7.3507 (3.0); 7.3447 (4.2); 7.3371 (2.2); 7.3221 (3.5); 7.3118 (1.0); 7.3065 (0.9); 7.2999 (0.9); 6.1612 (1.0); 6.1380 (3.6); 6.1141 (3.6); 6.0902 (1.0); 3.4098 (0.3); 3.3415 (8.7); 2.7275 (0.4); 2.5079 (44.2); 2.5021 (56.1); 2.4963 (38.6); 2.2719 (0.3); 1.8961 (13.7); 1.8722 (13.5); 1.2243 (0.7); 1.2037 (0.6); 0.9081 (0.3); 0.8804 (0.4); 0.0002 (9.3) I-33: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4003 (6.4); 8.6028 (11.1); 8.0123 (13.4); 8.0059 (16.0); 7.9527 (4.6); 7.9464 (6.8); 7.9401 (3.1); 7.4500 (1.6); 7.4433 (2.5); 7.4207 (7.4); 7.4160 (10.0); 7.3902 (7.0); 7.3703 (1.8); 7.3645 (2.9); 7.3527 (1.9); 7.3465 (2.8); 7.3393 (1.4); 7.3347 (1.2); 7.3240 (2.3); 7.3127 (0.6); 7.3026 (0.7); 7.2962 (0.4); 6.1624 (0.7); 6.1389 (2.4); 6.1149 (2.4); 6.0911 (0.6); 3.5354 (0.4); 2.5145 (9.3); 2.5087 (17.9); 2.5028 (23.2); 2.4969 (15.9); 2.0769 (0.5); 1.9010 (8.7); 1.8768 (8.5); 0.0001 (4.9) I-34: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4544 (8.6); 8.6142 (16.0); 7.8679 (3.2); 7.8419 (4.3); 7.8173 (1.0); 7.7931 (2.9); 7.7694 (3.4); 7.7483 (3.4); 7.7233 (3.9); 7.7118 (3.8); 7.6873 (2.2); 7.4562 (2.6); 7.4495 (4.0); 7.4265 (10.1); 7.4237 (10.0); 7.4163 (6.8); 7.4126 (6.8); 7.3899 (10.2); 7.3645 (4.8); 7.3517 (2.8); 7.3458 (4.4); 7.3390 (2.2); 7.3333 (1.8); 7.3231 (3.8); 7.3122 (0.9); 7.3008 (1.1); 6.1592 (0.9); 6.1351 (3.3); 6.1108 (3.4); 6.0879 (1.0); 4.8360 (0.4); 4.7564 (0.5); 4.7311 (0.5); 4.5808 (0.8); 4.5604 (0.8); 4.5041 (0.9); 4.4342 (0.8); 4.3630 (0.6); 2.7308 (0.5); 2.5138 (22.7); 2.5080 (43.5); 2.5021 (56.5); 2.4963 (38.6); 2.2725 (0.4); 1.9099 (12.8); 1.8859 (12.6); 0.0002 (8.1) I-35: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4762 (2.9); 8.5586 (6.1); 7.8657 (1.3); 7.8402 (1.8); 7.8156 (0.4); 7.7936 (1.1); 7.7695 (1.4); 7.7472 (1.4); 7.7211 (2.3); 7.6956 (1.0); 3.5642 (16.0); 2.5134 (9.6); 2.5076 (18.0); 2.5017 (23.0); 2.4958 (15.4); 0.0001 (5.2) I-36: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4218 (9.2); 9.1574 (6.4); 9.1514 (6.2); 8.8372 (4.4); 8.8322 (4.5); 8.8211 (4.6); 8.8159 (4.1); 8.6057 (16.0); 8.3870 (2.7); 8.3809 (3.7); 8.3742 (2.6); 8.3603 (2.8); 8.3539 (3.9); 8.3473 (2.4); 7.6544 (3.4); 7.6383 (3.4); 7.6286 (3.2); 7.6123 (2.9); 7.4516 (2.7); 7.4451 (4.1); 7.4223 (12.0); 7.4173 (14.6); 7.3913 (10.2); 7.3658 (4.4); 7.3528 (3.0); 7.3470 (4.1); 7.3394 (2.2); 7.3243 (3.4); 7.3133 (0.8); 7.3020 (1.0); 6.1650 (1.2); 6.1411 (3.7); 6.1171 (3.5); 6.0939 (1.0); 2.7277 (0.4); 2.5084 (46.5); 2.5026 (59.8); 2.4968 (42.0); 2.2725 (0.3); 1.9014 (13.4); 1.8773 (13.2); 1.1480 (0.4); 0.0002 (13.4) I-37: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.4 (1H), 9.15 (1H), 8.81 (1H), 8.53 (1H), 8.34 (1H), 7.61 (1H), 3.57 (3H) I-38: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.3515 (5.7); 8.6227 (16.0); 7.6094 (3.0); 7.6059 (3.2); 7.5860 (4.6); 7.5804 (5.7); 7.5743 (2.6); 7.5526 (6.3); 7.5484 (9.3); 7.5263 (5.2); 7.5205 (3.8); 7.5001 (2.2); 7.4938 (1.8); 7.4814 (3.7); 7.4745 (3.3); 7.4570 (6.1); 7.4507 (7.1); 7.4271 (11.1); 7.4166 (6.5); 7.4128 (6.4); 7.3901 (9.8); 7.3646 (4.4); 7.3519 (2.6); 7.3460 (4.0); 7.3392 (1.9); 7.3334 (1.6); 7.3234 (3.6); 7.3126 (0.7); 7.3008 (1.0); 6.1585 (0.9); 6.1351 (3.3); 6.1113 (3.4); 6.0868 (0.9); 3.3293 (15.9); 2.7281 (0.3); 2.5490 (0.3); 2.5136 (17.2); 2.5078 (33.2); 2.5020 (43.2); 2.4962 (29.6); 1.9091 (12.7); 1.8850 (12.6); 1.1440 (0.3); 0.0104 (0.4); 0.0001 (9.7) I-39: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.3742 (2.7); 8.5582 (6.0); 7.6182 (1.1); 7.6148 (1.1); 7.5948 (1.6); 7.5890 (1.7); 7.5779 (0.5); 7.5718 (0.8); 7.5466 (3.4); 7.5257 (2.1); 7.5198 (1.6); 7.4994 (0.8); 7.4931 (0.7); 7.4820 (1.5); 7.4749 (1.3); 7.4580 (1.4); 7.4515 (1.3); 7.4346 (0.6); 7.4284 (0.6); 3.5639 (16.0); 3.3269 (34.9); 2.5132 (10.0); 2.5074 (19.6); 2.5016 (25.6); 2.4958 (17.6); 0.0677 (0.6); 0.0001 (4.0) I-40: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.9733 (6.6); 8.5944 (15.3); 7.4422 (2.5); 7.4354 (3.8); 7.4082 (16.0); 7.3852 (10.0); 7.3593 (4.1); 7.3478 (2.7); 7.3412 (3.7); 7.3332 (2.2); 7.3189 (3.2); 7.2975 (0.9); 7.0803 (0.3); 6.1449 (1.1); 6.1215 (3.5); 6.0971 (3.5); 6.0730 (1.0); 4.3479 (0.4); 4.2193 (0.3); 4.1776 (0.3); 4.1411 (0.4); 4.0828 (0.4); 4.0668 (0.3); 4.0569 (0.3); 3.9729 (0.4); 3.9064 (0.4); 3.8209 (0.6); 2.7272 (0.4); 2.5079 (46.8); 2.5021 (60.1); 2.4964 (41.7); 2.1238 (0.7); 2.1008 (1.8); 2.0831 (3.1); 2.0736 (1.5); 2.0653 (1.8); 2.0583 (1.6); 2.0422 (0.8); 1.9046 (13.7); 1.8804 (13.3); 0.8838 (0.9); 0.8546 (8.1); 0.8288 (11.8); 0.8207 (9.5); 0.0001 (12.6); 0.0114 (0.6) I-41: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 7.2680 (0.4); 7.2441 (5.2); 7.2147 (8.1); 7.1859 (5.0); 6.5107 (0.7); 6.4105 (2.4); 6.3984 (4.5); 6.3850 (2.3); 6.1546 (11.2); 4.6384 (11.6); 4.6250 (11.6); 4.5799 (16.0); 4.0384 (0.3); 3.3119 (202.1); 2.7261 (0.7); 2.5480 (0.6); 2.5060 (86.3); 2.5004 (112.4); 2.4950 (83.2); 2.2709 (0.6); 1.9878 (0.9); 1.1751 (0.4); 1.1476 (0.6); 0.0003 (26.7) I-42: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 7.4597 (1.7); 7.4373 (2.2); 7.4308 (3.7); 7.4085 (3.8); 7.4018 (2.3); 7.3797 (2.0); 7.2965 (2.4); 7.2880 (2.6); 7.2652 (2.9); 7.2613 (3.1); 7.2568 (3.2); 7.2530 (3.0); 7.2302 (2.4); 7.2217 (2.5); 7.1175 (1.9); 7.1142 (2.0); 7.1088 (1.8); 7.1058 (1.8); 7.0891 (3.5); 7.0859 (3.6); 7.0804 (3.2); 7.0775 (3.0); 7.0607 (1.7); 7.0573 (1.7); 7.0520 (1.5); 7.0489 (1.4); 6.5035 (2.4); 6.4909 (4.5); 6.4781 (2.4); 6.1913 (11.4); 4.6863 (14.3); 4.6731 (14.1); 4.6379 (0.3); 4.6252 (0.5); 4.5887 (16.0); 3.8458 (0.4); 3.6155 (0.4); 3.3203 (34.0); 2.5135 (10.9); 2.5075 (21.2); 2.5015 (28.0); 2.4954 (19.2); 2.4895 (8.8); 1.9888 (0.7); 1.1746 (0.4); 1.1507 (0.4); 0.0107 (0.4); 0.0001 (9.1) I-43: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 14.0674 (0.4); 8.3186 (0.4); 6.7961 (0.4); 6.5228 (1.2); 6.3833 (6.6); 6.1506 (16.0); 4.6827 (15.4); 4.6710 (14.9); 4.5890 (0.5); 4.0745 (0.4); 3.8852 (4.2); 3.8481 (4.8); 3.5978 (0.6); 3.5579 (0.7); 3.4562 (7.9); 3.4106 (7.9); 3.3190 (79.8); 3.2510 (3.9); 3.2024 (1.2); 3.1722 (1.2); 3.1435 (0.8); 3.0818 (0.5); 3.0558 (0.5); 2.7276 (0.9); 2.6933 (0.5); 2.6549 (0.7); 2.6463 (0.6); 2.5014 (107.6); 2.3407 (0.9); 2.2958 (0.8); 2.2710 (1.2); 2.2431 (0.6); 2.2287 (0.6); 2.2121 (0.5); 2.1600 (0.5); 2.1268 (0.5); 1.9898 (0.7); 1.9724 (0.4); 1.8377 (0.8); 1.7653 (4.4); 1.6639 (0.7); 1.6037 (0.8); 1.5641 (4.2); 1.5191 (5.6); 1.4432 (14.8); 1.3264 (0.8); 1.2291 (2.2); 1.1839 (3.5); 1.1486 (4.0); 1.0733 (0.6); 1.0149 (0.4); 0.9422 (0.4); 0.0000 (13.0) I-44: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 12.4309 (0.5); 11.7181 (6.1); 11.6441 (0.5); 11.5712 (0.5); 8.5619 (16.0); 8.2355 (0.4); 6.7300 (3.5); 6.5525 (7.6); 6.3746 (3.8) ; 3.9747 (0.5); 3.9177 (11.3); 3.8939 (11.6); 3.3217 (34.4); 3.2233 (0.5); 3.0047 (0.4); 2.9536 (0.5); 2.8492 (0.6); 2.7271 (1.0); 2.5017 (139.0); 2.3926 (0.6); 2.3701 (0.6); 2.3533 (0.5); 2.3437 (0.5); 2.2706 (0.9); 2.1706 (0.4); 1.8798 (0.6); 1.8268 (1.9) ; 1.8009 (2.4); 1.7906 (2.3); 1.6691 (6.2); 1.6080 (8.5); 1.5702 (6.0); 1.3579 (0.5); 1.1599 (9.3); 1.1341 (6.5); 1.0565 (2.7); 1.0207 (4.5); 0.9832 (3.4); 0.9504 (1.5); 0.0000 (65.4) I-45: .sup.1H-NMR(300.0 MHz, d.sub.6-DMSO): = 10.6293 (3.8); 8.5191 (9.4); 3.9105 (5.2); 3.8863 (5.3); 3.3231 (10.9); 2.5141 (9.8); 2.5083 (19.2); 2.5024 (25.5); 2.4965 (17.8); 2.4632 (3.8); 2.4390 (7.6); 2.4147 (4.2); 1.8322 (0.5); 1.8214 (0.6); 1.8086 (0.7); 1.7970 (0.9); 1.7862 (0.8); 1.7725 (0.6); 1.7613 (0.6); 1.6756 (2.5); 1.6514 (3.8); 1.6268 (6.1); 1.6023 (7.6); 1.5779 (3.8); 1.5536 (2.7); 1.1880 (1.0); 1.1584 (3.6); 1.1305 (2.5); 1.0567 (1.0); 1.0178 (1.7); 0.9801 (1.3); 0.9561 (8.1); 0.9316 (16.0); 0.9069 (6.7); 0.0107 (1.0); 0.0001 (26.2); 0.0111 (1.0) I-46: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.6681 (4.9); 8.6908 (10.3); 8.4733 (3.1); 8.4584 (3.1); 7.8431 (1.6); 7.8375 (1.6); 7.8175 (3.2); 7.8119 (3.2); 7.7920 (1.9); 7.7866 (1.8); 7.4819 (3.9); 7.4560 (3.3); 7.3331 (2.2); 7.3162 (2.4); 7.3115 (2.3); 7.2934 (1.9); 7.1313 (0.3); 5.3962 (12.9); 3.3242 (15.1); 2.5072 (27.5); 2.5018 (34.8); 2.4812 (6.5); 2.4564 (8.8); 2.4322 (4.8); 1.6896 (0.6); 1.6651 (2.7); 1.6406 (5.3); 1.6162 (5.4); 1.5918 (2.8); 1.5673 (0.7); 0.9679 (8.3); 0.9434 (16.0); 0.9187 (7.2); 0.0001 (23.8) I-47: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.6327 (2.9); 8.6895 (5.3); 8.4717 (2.0); 8.4552 (2.0); 7.8373 (1.0); 7.8119 (2.0); 7.7863 (1.2); 7.4800 (2.3); 7.4540 (2.1); 7.3327 (1.4); 7.3165 (1.5); 7.2916 (1.3); 7.2111 (0.4); 7.1866 (0.4); 7.1320 (0.5); 5.3954 (7.7); 3.3192 (20.2); 2.9019 (0.5); 2.8794 (1.1); 2.8566 (1.5); 2.8341 (1.2); 2.8122 (0.6); 2.7277 (0.4); 2.7128 (0.5); 2.6892 (0.4); 2.5012 (34.4); 2.4162 (0.4); 2.3922 (0.4); 1.1446 (16.0); 1.1220 (15.4); 1.0681 (1.8); 1.0448 (1.7); 0.0003 (15.5) I-48: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.7199 (2.3); 8.5858 (5.5); 6.7323 (1.2); 6.5547 (2.7); 6.3772 (1.3); 3.5668 (16.0); 3.3321 (4.8); 2.5067 (17.3); 2.5012 (21.3); 2.4959 (15.9); 0.0001 (3.8) I-49: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.6359 (2.3); 8.5466 (5.6); 7.1298 (0.4); 3.5574 (16.0); 3.3235 (39.5); 2.5070 (37.1); 2.5015 (47.2); 2.4962 (35.2); 2.4668 (2.8); 2.4426 (5.0); 2.4183 (2.7); 1.6492 (1.6); 1.6248 (3.0); 1.6003 (3.0); 1.5760 (1.6); 1.5513 (0.4); 0.9533 (4.6); 0.9288 (9.0); 0.9042 (4.0); 0.0001 (23.9) I-50: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.6197 (2.8); 8.5490 (5.2); 7.2116 (0.5); 7.1879 (0.4); 7.1281 (0.6); 7.1033 (0.4); 3.5585 (15.1); 3.3313 (75.3); 2.9000 (0.5); 2.8762 (1.2); 2.8536 (1.6); 2.8312 (1.2); 2.8082 (0.6); 2.7301 (0.3); 2.5023 (40.3); 1.1274 (16.0); 1.1047 (15.4); 1.0668 (0.5); 0.0001 (11.7) I-51: .sup.1H-NMR(300.0 MHz, d.sub.6-DMSO): = 10.6762 (0.6); 10.6201 (5.8); 8.5846 (8.1); 7.4092 (16.0); 7.3851 (9.8); 7.3601 (5.3); 7.3197 (3.5); 7.2741 (0.4); 6.1203 (3.3); 6.0963 (3.3); 3.4453 (0.3); 3.3928 (0.9); 3.3269 (21.7); 3.1236 (0.4); 3.0689 (0.4); 3.0511 (0.4); 3.0460 (0.4); 3.0144 (0.4); 2.9829 (0.4); 2.9018 (0.3); 2.8833 (0.3); 2.8470 (0.3); 2.8080 (0.3); 2.7300 (0.8); 2.6756 (0.6); 2.5026 (81.2); 2.4441 (7.3); 2.4198 (9.8); 2.3965 (5.9); 2.2710 (0.9); 2.2026 (0.4); 2.1454 (0.4); 2.0886 (0.4); 2.0304 (0.4); 1.9003 (11.8); 1.8774 (11.7); 1.6432 (3.3); 1.6184 (5.8); 1.5943 (5.8); 1.5706 (3.4); 1.4777 (0.4); 1.2430 (0.8); 1.1945 (0.4); 1.1382 (0.4); 1.0913 (0.8); 1.0678 (0.6); 0.9511 (8.1); 0.9267 (13.6); 0.9027 (7.2); 0.0002 (28.5); 0.0995 (0.4); 0.1159 (0.3); 0.2015 (0.3) I-52: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.5879 (3.5); 8.5976 (4.7); 7.4102 (8.7); 7.3846 (5.5); 7.3594 (3.0); 7.3421 (2.7); 7.3198 (2.0); 6.1217 (1.8); 6.0981 (1.8); 3.3944 (0.9); 3.3710 (1.2); 3.3265 (14.5); 2.8528 (0.8); 2.8308 (1.4); 2.8067 (1.8); 2.7852 (1.4); 2.7626 (0.8); 2.7320 (0.5); 2.6521 (0.3); 2.6360 (0.4); 2.5028 (48.4); 2.2723 (0.4); 1.9002 (6.8); 1.8765 (6.5); 1.2446 (0.7); 1.1226 (16.0); 1.1006 (15.4); 0.8610 (0.5); 0.0000 (18.5) I-53: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 12.3918 (2.1); 12.3503 (0.4); 8.5502 (16.0); 3.9106 (9.2); 3.8863 (9.3); 3.3474 (31.6); 2.7281 (0.6); 2.5133 (29.9); 2.5076 (58.4); 2.5017 (76.9); 2.4958 (54.3); 2.2718 (0.5); 1.8337 (1.0); 1.8226 (1.2); 1.8105 (1.3); 1.7975 (1.6); 1.7864 (1.5); 1.7736 (1.2); 1.7625 (1.1); 1.6685 (3.9); 1.6068 (5.5); 1.5637 (3.9); 1.2372 (0.6); 1.1915 (2.0); 1.1595 (6.5); 1.1320 (4.4); 1.0553 (1.7); 1.0200 (3.0); 0.9794 (2.2); 0.0001 (19.8) I-54: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.6183 (3.2); 8.5185 (9.0); 3.9124 (4.7); 3.8880 (4.8); 3.3199 (8.7); 2.5142 (6.6); 2.5081 (12.6); 2.5020 (17.1); 2.4956 (13.8); 2.4680 (6.3); 2.4431 (2.0); 1.8340 (0.4); 1.8226 (0.5); 1.8092 (0.6); 1.7974 (0.8); 1.7858 (0.6); 1.7718 (0.6); 1.7613 (0.5); 1.6682 (1.8); 1.6028 (2.4); 1.5560 (1.8); 1.1882 (0.8); 1.1590 (3.1); 1.1310 (2.1); 1.1043 (7.6); 1.0794 (16.0); 1.0543 (7.4); 1.0193 (1.4); 0.9803 (1.1); 0.9506 (0.3); 0.9391 (0.3); 0.0001 (5.2) I-55: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 10.6946 (3.0); 8.5213 (5.5); 3.9141 (4.5); 3.8902 (4.8); 3.3220 (9.6); 3.3189 (10.0); 2.5057 (25.2); 2.5013 (25.6); 2.3988 (0.3); 2.3743 (0.4); 2.2756 (0.4); 2.2179 (0.4); 2.1590 (16.0); 1.9089 (0.4); 1.7979 (1.2); 1.6697 (2.8); 1.6034 (3.6); 1.5604 (2.8); 1.1592 (4.2); 1.1340 (3.1); 1.0598 (1.3); 1.0212 (2.1); 0.9820 (1.6); 0.0036 (8.5); 0.0002 (8.8) I-56: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 11.1369 (3.9); 8.5528 (7.9); 4.4722 (16.0); 3.9177 (4.9); 3.8934 (5.0); 3.3192 (18.8); 2.5077 (14.9); 2.5020 (19.1); 2.4963 (13.8); 1.8372 (0.5); 1.8249 (0.7); 1.8128 (0.7); 1.8008 (0.9); 1.7895 (0.8); 1.7764 (0.7); 1.7649 (0.6); 1.6699 (2.2); 1.6052 (3.2); 1.5648 (2.3); 1.1595 (3.7); 1.1316 (2.6); 1.0587 (1.0); 1.0204 (1.7); 0.9828 (1.3); 0.9497 (0.4); 0.0001 (4.1) I-57: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 12.4113 (3.6); 8.5542 (16.0); 3.9041 (8.9); 3.8798 (8.9); 3.3947 (0.3); 3.3403 (13.0); 2.5136 (17.0); 2.5079 (32.8); 2.5020 (42.8); 2.4960 (29.7); 2.4904 (13.7); 1.8237 (1.1); 1.8118 (1.3); 1.7999 (1.6); 1.7890 (1.4); 1.7771 (1.2); 1.7658 (1.1); 1.7389 (0.6); 1.6698 (3.7); 1.6066 (5.4); 1.5640 (3.8); 1.1588 (6.3); 1.1311 (4.2); 1.0910 (1.0); 1.0559 (1.6); 1.0176 (2.8); 0.9782 (2.2); 0.9407 (0.6); 0.0107 (0.5); 0.0001 (10.1) I-58: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 12.3878 (4.1); 8.5529 (16.0); 3.9048 (9.1); 3.8805 (9.0); 3.3713 (6.9); 2.7269 (0.5); 2.5133 (31.2); 2.5076 (58.7); 2.5017 (76.0); 2.4958 (53.1); 2.2720 (0.5); 1.8253 (1.2); 1.8008 (1.7); 1.7882 (1.5); 1.7740 (1.2); 1.6672 (4.2); 1.6068 (6.0); 1.5644 (4.3); 1.2322 (0.7); 1.1887 (2.1); 1.1572 (7.0); 1.1311 (4.7); 1.0548 (1.8); 1.0161 (3.1); 0.9804 (2.4); 0.0001 (20.7); 0.0111 (0.8) I-59: .sup.1H-NMR(3.001 MHz, d.sub.6-DMSO): = 6.39 (1H), 6.15 (2H), 4.63 (2H), 3.18 (2H), 1.78-1.32 (11H), 1.17-1.07 (2H) I-60: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 7.39-7.32 (2H), 7.24-7.17 (2H), 6.50 (1H), 6.18 (2H), 4.69 (2H), 4.63 (2H) I-61: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 7.3908 (0.5); 7.3659 (0.5); 7.2451 (0.6); 7.2159 (0.6); 6.3913 (2.6); 6.3782 (5.1); 6.3651 (2.6); 6.1447 (13.2); 4.9982 (0.3); 4.6351 (16.0); 4.6214 (15.7); 3.3186 (34.8); 3.1960 (10.6); 3.1726 (11.4); 2.7334 (0.5); 2.7271 (0.6); 2.5128 (35.5); 2.5070 (68.2); 2.5010 (89.4); 2.4952 (61.5); 2.4895 (28.9); 2.2708 (0.6); 2.0742 (0.4); 1.6613 (9.7); 1.6235 (9.6); 1.5873 (3.5); 1.5617 (1.9); 1.5169 (0.4); 1.2425 (0.8); 1.2026 (2.4); 1.1643 (6.4); 1.1331 (4.4); 1.0952 (1.0); 0.9579 (1.6); 0.9227 (3.3); 0.8907 (2.7); 0.0108 (3.2); 0.0001 (76.3); 0.0112 (2.7) I-62: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 7.9587 (0.4); 7.3213 (1.1); 7.3177 (1.0); 7.3058 (1.4); 7.2901 (2.9); 7.2749 (3.1); 7.2592 (2.3); 7.2453 (2.4); 7.2281 (1.4); 7.2168 (2.3); 7.2032 (2.7); 7.1896 (5.7); 7.1749 (3.8); 7.1622 (4.6); 7.1480 (2.3); 7.1431 (2.5); 7.1326 (1.3); 7.0964 (1.6); 6.5709 (2.2); 6.5575 (4.4); 6.5443 (2.3); 6.2282 (11.2); 4.7249 (13.5); 4.7113 (13.4); 4.6896 (0.6); 4.6121 (16.0); 3.3286 (37.5); 2.7280 (0.3); 2.5140 (19.6); 2.5080 (38.6); 2.5021 (51.4); 2.4962 (35.7); 2.4905 (16.9); 2.2721 (0.4); 2.0759 (0.5); 0.0108 (1.6); 0.0001 (45.5); 0.0112 (1.8) I-63: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 6.3916 (2.5); 6.3780 (4.6); 6.3654 (2.5); 6.1576 (12.2); 4.6690 (16.0); 4.6553 (15.8); 3.3258 (61.8); 3.2915 (13.3); 3.2660 (13.7); 2.7333 (0.5); 2.7279 (0.6); 2.5134 (38.7); 2.5075 (76.6); 2.5015 (102.3); 2.4956 (70.8); 2.4899 (33.3); 2.2844 (0.4); 2.2770 (0.6); 2.2710 (0.6); 2.2651 (0.6); 2.2198 (0.9); 2.1953 (2.2); 2.1708 (3.2); 2.1463 (2.7); 2.1210 (1.2); 2.0753 (1.3); 1.7016 (1.1); 1.6641 (3.1); 1.6432 (4.2); 1.6250 (5.6); 1.6112 (4.9); 1.6018 (4.6); 1.5938 (4.5); 1.5727 (3.6); 1.5470 (3.3); 1.5164 (4.3); 1.5045 (3.4); 1.4914 (3.5); 1.4832 (2.7); 1.4645 (2.2); 1.2504 (1.6); 1.2251 (2.5); 1.2098 (3.5); 1.1882 (3.0); 1.1666 (2.4); 0.0695 (0.4); 0.0108 (3.0); 0.0001 (80.3); 0.0112 (3.0); 0.1986 (0.3) I-64: .sup.1H-NMR(300.1 MHz, d.sub.6-DMSO): = 7.3926 (4.2); 7.3735 (5.4); 7.3642 (6.6); 7.3454 (5.7); 7.2057 (6.3); 7.1760 (10.5); 7.1532 (2.4); 7.1465 (4.9); 6.4868 (2.1); 6.4738 (3.9); 6.4624 (2.3); 6.2307 (0.4); 6.1853 (9.8); 5.7281 (0.4); 4.6488 (11.8); 4.6360 (12.6); 4.5593 (16.0); 3.8496 (0.4); 3.8335 (0.5); 3.5828 (0.5); 3.3264 (58.4); 3.3032 (1.4); 2.7223 (0.8); 2.6921 (0.4); 2.6723 (0.3); 2.6488 (0.5); 2.6222 (0.5); 2.6075 (0.6); 2.5073 (79.3); 2.5017 (102.6); 2.4961 (74.9); 2.3972 (0.3); 2.2723 (0.6); 2.2656 (0.6); 2.0757 (0.8); 0.0680 (0.4); 0.0384 (0.5); 0.0107 (3.3); 0.0001 (60.1) I-65: 1H-NMR(400.2 MHz, d6-DMSO): = 6.8079 (16.0); 4.1122 (6.8); 4.0948 (6.7); 3.3342 (14.7); 3.1825 (1.3); 3.1695 (1.2); 2.6793 (0.8); 2.5143 (84.8); 2.5104 (111.7); 2.5064 (87.5); 2.3370 (0.7); 1.9263 (1.5); 1.9015 (2.3); 1.8818 (1.8); 1.6878 (6.1); 1.6121 (8.1); 1.5796 (5.8); 1.1700 (9.1); 1.1502 (8.2); 1.1043 (4.6); 1.0754 (3.3); 0.1541 (0.5); 0.0082 (78.0); 0.1411 (0.4) I-66: 1H-NMR(300.1 MHz, d6-DMSO): = 6.8082 (2.4); 4.2324 (1.9); 4.2074 (1.9); 3.3316 (12.8); 2.5237 (6.1); 2.5177 (12.1); 2.5117 (16.0); 2.5058 (10.9); 2.4999 (4.9); 2.4675 (0.4); 2.4432 (0.5); 2.4183 (0.4); 1.6719 (1.5); 1.6611 (1.3); 1.5579 (0.5); 1.5289 (0.8); 1.3870 (0.5); 1.3640 (0.7); 1.3429 (0.6); 1.3248 (0.4); 0.0098 (6.9) I-67: 1H-NMR(400.0 MHz, d6-DMSO): = 12.1327 (8.8); 8.5468 (14.4); 8.5401 (13.1); 3.8964 (13.2); 3.8835 (14.1); 3.3720 (4.1); 3.3101 (191.3); 3.3038 (150.5); 2.7343 (4.4); 2.6626 (8.6); 2.6233 (7.9); 2.5637 (15.3); 2.5000 (475.4); 2.4967 (496.6); 2.4129 (4.8); 2.3277 (4.4); 1.7959 (4.8); 1.6644 (10.9); 1.5969 (13.0); 1.5665 (10.4); 1.1549 (16.0); 1.0127 (7.8); 0.9869 (6.3); 0.0002 (2.7) I-68: 1H-NMR(400.0 MHz, d6-DMSO): = 12.2410 (8.3); 8.5427 (13.0); 8.5342 (13.1); 3.8938 (13.2); 3.8834 (13.6); 3.3738 (2.8); 3.3119 (101.9); 3.3035 (87.8); 3.2207 (1.2); 2.6658 (5.7); 2.5605 (9.4); 2.4971 (276.5); 2.4118 (2.6); 2.3239 (2.3); 1.8003 (4.8); 1.6645 (11.3); 1.5977 (13.3); 1.5646 (11.1); 1.1537 (16.0); 1.0134 (7.9); 0.9863 (6.6); 0.0002 (1.2); 0.0084 (1.2) I-69: 1H-NMR(400.0 MHz, d6-DMSO): = 10.2976 (3.1); 8.5355 (8.3); 4.1435 (16.0); 3.9109 (4.6); 3.8926 (4.7); 3.4125 (34.6); 3.3082 (29.5); 2.5235 (1.5); 2.5188 (2.2); 2.5101 (26.8); 2.5056 (57.2); 2.5010 (79.3); 2.4964 (56.5); 2.4919 (26.2); 1.8146 (0.5); 1.8051 (0.6); 1.7959 (0.7); 1.7872 (0.6); 1.7766 (0.5); 1.6849 (1.2); 1.6689 (1.6); 1.5932 (1.9); 1.5634 (1.6); 1.1830 (1.0); 1.1571 (3.0); 1.1368 (1.9); 1.0459 (0.6); 1.0160 (1.3); 0.9870 (1.1); 0.0002 (12.4) I-70: 1H-NMR(400.0 MHz, d6-DMSO): = 8.5507 (14.4); 3.9121 (7.3); 3.8938 (7.5); 3.8594 (16.0); 3.3092 (17.0); 2.6747 (0.6); 2.6701 (0.8); 2.6654 (0.6); 2.5235 (2.3); 2.5188 (3.4); 2.5101 (44.5); 2.5056 (95.1); 2.5010 (131.5); 2.4964 (92.0); 2.4918 (41.2); 2.4732 (0.6); 2.4685 (0.6); 2.3324 (0.6); 2.3278 (0.8); 2.3232 (0.6); 1.8253 (0.6); 1.8162 (0.8); 1.8062 (0.9); 1.7973 (1.2); 1.7885 (1.0); 1.7784 (0.8); 1.7698 (0.8); 1.6857 (1.9); 1.6696 (2.5); 1.6029 (3.2); 1.5694 (2.6); 1.1839 (1.5); 1.1584 (4.7); 1.1386 (3.0); 1.0478 (1.0); 1.0177 (2.0); 0.9884 (1.6); 0.9656 (0.5); 0.0080 (0.8); 0.0002 (26.3); 0.0086 (0.8) I-71: 1H-NMR(400.0 MHz, d6-DMSO): = 11.0521 (1.0); 8.5459 (4.4); 3.9149 (2.1); 3.8965 (2.1); 3.6822 (5.6); 3.6600 (16.0); 3.3087 (18.5); 2.5237 (0.6); 2.5190 (0.9); 2.5103 (12.3); 2.5057 (26.8); 2.5011 (37.4); 2.4965 (26.2); 2.4919 (11.9); 1.6866 (0.6); 1.6713 (0.8); 1.6031 (0.9); 1.5711 (0.8); 1.1580 (1.4); 1.1381 (0.9); 1.0183 (0.6); 0.0002 (7.2) I-72: 1H-NMR(400.0 MHz, d6-DMSO): = 10.7889 (1.2); 8.5269 (4.4); 3.9131 (2.5); 3.8948 (2.5); 3.6100 (0.6); 3.5970 (16.0); 3.5864 (0.6); 3.3114 (7.6); 2.8019 (1.0); 2.7864 (2.2); 2.7688 (1.6); 2.6186 (1.8); 2.6010 (2.5); 2.5855 (1.2); 2.5118 (5.6); 2.5074 (11.6); 2.5029 (15.6); 2.4984 (11.0); 2.4940 (5.1); 1.6860 (0.7); 1.6709 (0.9); 1.5944 (1.1); 1.5654 (0.9); 1.1842 (0.6); 1.1580 (1.7); 1.1382 (1.1); 1.0184 (0.8); 0.9892 (0.6); 0.0002 (2.2) I-73: 1H-NMR(400.0 MHz, d6-DMSO): = 11.1798 (4.9); 8.5552 (16.0); 4.0392 (0.6); 4.0214 (0.6); 3.9151 (8.3); 3.8968 (8.4); 3.7881 (2.1); 3.7604 (6.7); 3.7327 (7.0); 3.7049 (2.4); 3.3182 (13.5); 2.5247 (1.6); 2.5199 (2.2); 2.5112 (31.4); 2.5067 (68.1); 2.5021 (95.2); 2.4975 (66.8); 2.4930 (30.0); 2.3288 (0.6); 1.9888 (2.5); 1.8321 (0.8); 1.8230 (0.9); 1.8132 (1.0); 1.8043 (1.3); 1.7954 (1.1); 1.7859 (0.9); 1.6716 (2.9); 1.6033 (3.8); 1.5705 (2.9); 1.2353 (0.5); 1.1935 (1.8); 1.1757 (2.6); 1.1580 (5.8); 1.1385 (3.4); 1.0469 (1.1); 1.0190 (2.3); 0.9894 (1.9); 0.0080 (0.9); 0.0002 (30.3); 0.0084 (0.8) I-74: 1H-NMR(400.0 MHz, d6-DMSO): = 10.0177 (0.9); 5.7531 (1.5); 3.9823 (1.2); 3.9641 (1.2); 3.3081 (6.8); 2.5815 (0.7); 2.5365 (6.0); 2.5105 (6.5); 2.5059 (14.0); 2.5013 (19.4); 2.4968 (13.7); 2.4922 (6.2); 1.6007 (0.6); 1.4671 (16.0); 1.1660 (0.8); 0.0002 (11.5) I-75: 1H-NMR(400.0 MHz, d6-DMSO): = 6.6314 (13.6); 5.7537 (1.4); 3.9408 (15.8); 3.9226 (16.0); 3.3601 (0.7); 3.3098 (95.0); 2.6754 (0.7); 2.6708 (1.0); 2.6662 (0.7); 2.5894 (73.5); 2.5562 (0.6); 2.5515 (0.9); 2.5468 (0.9); 2.5420 (0.7); 2.5242 (2.7); 2.5195 (3.9); 2.5109 (55.5); 2.5063 (119.6); 2.5017 (166.4); 2.4971 (117.9); 2.4926 (53.8); 2.3331 (0.7); 2.3285 (1.0); 2.3239 (0.8); 1.9052 (0.7); 1.8963 (1.3); 1.8872 (1.5); 1.8776 (1.7); 1.8686 (2.2); 1.8596 (1.8); 1.8502 (1.5); 1.8412 (1.4); 1.8321 (0.7); 1.6655 (3.5); 1.6554 (4.3); 1.6511 (4.2); 1.6436 (3.9); 1.5874 (6.3); 1.5522 (4.5); 1.2341 (1.1); 1.1835 (2.4); 1.1604 (8.0); 1.1403 (4.8); 1.0432 (1.6); 1.0146 (3.4); 0.9859 (2.8); 0.9639 (0.9); 0.9557 (0.9); 0.0081 (0.7); 0.0002 (22.8); 0.0085 (0.7) I-76: 1H-NMR(400.0 MHz, d6-DMSO): = 12.2756 (5.1); 8.7170 (10.9); 7.4989 (1.6); 7.4822 (2.1); 7.4770 (3.5); 7.4606 (3.6); 7.4554 (2.1); 7.4389 (1.8); 7.3115 (2.0); 7.3051 (2.1); 7.2880 (2.6); 7.2841 (3.0); 7.2784 (2.5); 7.2614 (2.1); 7.2550 (2.1); 7.1024 (1.7); 7.1002 (1.7); 7.0959 (1.7); 7.0811 (3.2); 7.0790 (3.2); 7.0746 (3.1); 7.0598 (1.6); 7.0533 (1.5); 5.2749 (16.0); 3.3280 (11.2); 3.1700 (1.0); 2.6748 (0.6); 2.6704 (0.7); 2.6659 (0.5); 2.5399 (0.6); 2.5237 (2.3); 2.5189 (3.4); 2.5103 (46.7); 2.5058 (95.2); 2.5013 (126.0); 2.4968 (89.7); 2.4924 (42.9); 2.3326 (0.6); 2.3281 (0.8); 2.3238 (0.6); 0.0080 (1.1); 0.0002 (34.7); 0.0085 (1.3) I-77: 1H-NMR(400.00 MHz, d6-DMSO): = 12.1654 (5.0); 8.7219 (10.8); 7.4986 (1.6); 7.4820 (2.0); 7.4768 (3.5); 7.4603 (3.6); 7.4550 (2.2); 7.4385 (1.8); 7.3112 (2.0); 7.3048 (2.1); 7.2876 (2.5); 7.2837 (3.0); 7.2782 (2.6); 7.2612 (2.1); 7.2547 (2.2); 7.0998 (1.7); 7.0953 (1.7); 7.0786 (3.2); 7.0741 (3.1); 7.0593 (1.6); 7.0528 (1.5); 5.2745 (16.0); 3.3118 (36.4); 2.6745 (0.8); 2.6700 (1.1); 2.6655 (0.8); 2.5234 (3.4); 2.5185 (5.0); 2.5100 (66.2); 2.5055 (135.6); 2.5009 (180.0); 2.4964 (128.0); 2.4921 (61.1); 2.3322 (0.8); 2.3278 (1.1); 2.3231 (0.8); 0.0079 (1.7); 0.0002 (51.3); 0.0085 (1.9) I-78: 1H-NMR(400.00 MHz, d6-DMSO): = 12.4181 (3.3); 8.7245 (10.6); 7.5001 (1.6); 7.4834 (2.1); 7.4782 (3.5); 7.4618 (3.6); 7.4564 (2.1); 7.4400 (1.8); 7.3123 (2.0); 7.3060 (2.1); 7.2888 (2.5); 7.2851 (3.0); 7.2795 (2.6); 7.2624 (2.0); 7.2560 (2.1); 7.1005 (1.7); 7.0962 (1.7); 7.0813 (3.2); 7.0793 (3.2); 7.0748 (3.1); 7.0579 (1.6); 7.0536 (1.6); 5.2748 (16.0); 3.3911 (6.3); 2.6750 (0.6); 2.6704 (0.9); 2.6659 (0.6); 2.5238 (2.4); 2.5190 (3.8); 2.5104 (53.0); 2.5059 (108.5); 2.5014 (144.7); 2.4968 (102.8); 2.4925 (49.5); 2.3329 (0.6); 2.3282 (0.9); 2.3235 (0.7); 2.0730 (0.9); 0.0080 (1.3); 0.0002 (40.4); 0.0085 (1.6) I-79: 1H-NMR(400.0 MHz, d6-DMSO): = 10.7130 (1.8); 8.7011 (4.0); 7.4658 (0.6); 7.4447 (1.2); 7.4287 (1.2); 7.4074 (0.7); 7.3065 (0.8); 7.2840 (1.2); 7.2628 (0.8); 7.0975 (0.8); 7.0766 (1.3); 7.0527 (0.6); 5.2818 (6.1); 3.3097 (17.2); 2.6697 (0.6); 2.5605 (1.3); 2.5051 (76.3); 2.5008 (99.3); 2.4964 (71.1); 2.2664 (0.8); 2.1619 (16.0); 0.0002 (20.5) I-80: 1H-NMR(400.0 MHz, d6-DMSO): = 10.9316 (6.6); 8.7215 (10.1); 8.6156 (0.8); 7.4737 (1.4); 7.4521 (3.1); 7.4355 (3.3); 7.4137 (1.8); 7.3132 (1.8); 7.3082 (1.9); 7.2859 (3.4); 7.2637 (1.8); 7.2579 (1.9); 7.1007 (1.9); 7.0794 (3.5); 7.0735 (3.3); 7.0584 (1.8); 6.8171 (0.7); 5.2853 (16.0); 5.2568 (1.7); 5.2179 (10.6); 5.1011 (10.8); 3.3104 (71.8); 2.6698 (2.4); 2.5047 (329.4); 2.5010 (379.9); 2.4035 (0.7); 2.3280 (2.4); 2.0720 (1.4); 0.0015 (64.4); 0.0002 (68.4) I-81: 1H-NMR(400.0 MHz, d6-DMSO): = 11.3382 (0.5); 8.7317 (7.2); 8.7293 (6.9); 7.4830 (1.1); 7.4665 (1.4); 7.4611 (2.5); 7.4448 (2.5); 7.4393 (1.6); 7.4230 (1.3); 7.3149 (1.4); 7.3084 (1.5); 7.2914 (1.7); 7.2857 (2.1); 7.2818 (1.8); 7.2649 (1.5); 7.2584 (1.5); 7.1000 (1.2); 7.0958 (1.2); 7.0788 (2.2) ; 7.0744 (2.2); 7.0598 (1.1); 7.0574 (1.1); 7.0531 (1.1); 5.2833 (11.1); 3.8610 (16.0); 3.3080 (23.2); 2.6742 (0.9); 2.6696 (1.3) ; 2.6650 (0.9); 2.5231 (3.8); 2.5183 (5.3); 2.5096 (70.6); 2.5051 (150.6); 2.5006 (208.0); 2.4960 (151.2); 2.4915 (73.7); 2.3320 (0.9); 2.3274 (1.3); 2.3228 (1.0); 2.0724 (1.2); 0.0080 (1.8); 0.0002 (59.9); 0.0085 (2.5) I-82: 1H-NMR(400.0 MHz, d6-DMSO): = 11.2108 (6.2); 8.7392 (10.4); 7.4730 (1.7); 7.4512 (3.5); 7.4347 (3.5); 7.4293 (2.2); 7.4127 (1.8); 7.3139 (2.0); 7.3075 (2.1); 7.2857 (3.1); 7.2638 (2.1); 7.2575 (2.1); 7.0975 (1.7); 7.0913 (1.7); 7.0747 (3.2); 7.0696 (3.1); 7.0555 (1.6); 7.0487 (1.5); 5.2854 (16.0); 3.7921 (2.6); 3.7642 (8.0); 3.7365 (8.4); 3.7086 (2.9); 3.3064 (128.3); 2.6741 (2.0); 2.6695 (2.7); 2.6651 (2.0); 2.5229 (8.6); 2.5180 (12.6); 2.5095 (160.4); 2.5050 (327.4); 2.5005 (437.9); 2.4960 (312.5); 2.4916 (150.1); 2.4106 (0.5); 2.3319 (2.0); 2.3274 (2.7); 2.3228 (1.9); 2.0721 (4.2); 0.1461 (0.5); 0.0078 (3.9); 0.0002 (115.4); 0.0085 (4.6); 0.1496 (0.5) I-83: 1H-NMR(400.0 MHz, d6-DMSO): = 10.3399 (3.6); 8.7190 (5.0); 8.7169 (4.9); 7.4722 (0.8); 7.4556 (1.0); 7.4504 (1.7); 7.4341 (1.7); 7.4286 (1.1); 7.4122 (0.9); 7.3144 (1.0); 7.3080 (1.1); 7.2911 (1.2); 7.2850 (1.5); 7.2814 (1.3); 7.2644 (1.0); 7.2579 (1.0); 7.0990 (0.8); 7.0931 (0.8); 7.0779 (1.6); 7.0728 (1.5); 7.0562 (0.8); 7.0510 (0.7); 5.2824 (7.9); 4.1475 (16.0); 3.4125 (31.5); 3.3073 (59.8); 2.6740 (0.8); 2.6697 (1.0); 2.6652 (0.8); 2.5230 (2.9); 2.5182 (4.3); 2.5095 (59.6); 2.5051 (124.6); 2.5006 (170.4); 2.4961 (124.0); 2.4917 (61.3); 2.3319 (0.8); 2.3275 (1.1); 2.3228 (0.8); 2.0724 (9.0); 0.0080 (1.4); 0.0002 (44.1); 0.0081 (1.9) I-84: 1H-NMR(400.00 MHz, d6-DMSO): = 10.6392 (4.4); 8.6979 (6.7); 8.6147 (3.9); 7.4652 (1.1); 7.4433 (2.3); 7.4268 (2.8); 7.4069 (2.1); 7.3910 (1.4); 7.3706 (0.7); 7.3056 (1.7); 7.2843 (3.1); 7.2578 (1.7); 7.0913 (1.8); 7.0705 (3.2); 7.0481 (1.5); 6.8186 (4.5); 5.7531 (0.9); 5.2796 (10.8); 5.2549 (6.6); 3.3697 (0.9); 3.3557 (3.5); 3.3083 (322.5); 2.6694 (4.0); 2.5039 (473.6); 2.5003 (650.2); 2.4958 (498.8); 2.4745 (28.3); 2.3267 (3.7); 1.2368 (0.7); 1.1677 (1.0); 1.0997 (7.7); 1.0810 (16.0); 1.0622 (7.6); 0.0080 (3.5); 0.0002 (85.1); 0.0015 (64.7) I-85: 1H-NMR(400.00 MHz, d6-DMSO): = 12.3983 (3.7); 8.7215 (10.2); 7.4934 (1.7); 7.4723 (3.4); 7.4556 (3.3); 7.4346 (1.8); 7.3158 (2.0); 7.3097 (2.1); 7.2873 (3.3); 7.2661 (2.0); 7.2598 (2.0); 7.1032 (1.9); 7.0811 (3.3); 7.0602 (1.7); 6.8211 (0.7); 5.7530 (0.8); 5.2793 (16.0); 3.3604 (2.9); 3.3097 (318.8); 2.6694 (4.4); 2.5040 (495.9); 2.5003 (673.6); 2.4959 (518.0); 2.3275 (4.0); 2.0722 (1.1); 1.2347 (1.0); 1.1669 (1.0); 0.0080 (3.0); 0.0002 (81.1) I-86: 1H-NMR(400.0 MHz, d6-DMSO): = 12.4702 (1.1); 3.9923 (16.0); 3.9742 (16.0); 3.3269 (144.5); 2.6741 (4.6); 2.6695 (6.4); 2.6649 (4.5); 2.5605 (7.3); 2.5560 (8.9); 2.5512 (9.7); 2.5465 (9.0); 2.5228 (42.2); 2.5181 (54.3); 2.5095 (371.4); 2.5050 (760.7); 2.5004 (1040.8); 2.4958 (755.1); 2.4914 (371.3); 2.4553 (5.8); 2.4506 (7.1); 2.4460 (4.9); 2.3318 (4.4); 2.3272 (6.0); 2.3226 (4.2); 2.0724 (0.9); 1.8912 (2.2); 1.6608 (5.2); 1.6119 (6.9); 1.5909 (6.7); 1.2343 (1.3); 1.1673 (9.7); 1.1486 (6.0); 1.0636 (2.2); 1.0351 (4.2); 1.0052 (3.4); 0.0080 (6.1); 0.0002 (179.8); 0.0085 (6.8); 0.0499 (1.4) I-87: 1H-NMR(400.0 MHz, d6-DMSO): = 12.7643 (4.3); 6.6185 (16.0); 3.3153 (124.2); 2.6764 (0.5); 2.6718 (0.7); 2.6672 (0.5); 2.5768 (91.9); 2.5531 (0.6); 2.5252 (2.6); 2.5204 (3.9); 2.5118 (42.3); 2.5073 (88.6); 2.5027 (121.4); 2.4981 (86.9); 2.4936 (40.5); 2.4140 (0.5); 2.3341 (0.6); 2.3295 (0.8); 2.3249 (0.6); 0.0080 (1.5); 0.0002 (42.1); 0.0085 (1.4) I-88: 1H-NMR(400.0 MHz, d6-DMSO): = 3.3122 (27.0); 2.5224 (6.6); 2.5101 (7.6); 2.5056 (16.5); 2.5010 (23.0); 2.4964 (16.3); 2.4919 (7.4); 1.4656 (16.0); 0.0002 (0.8)

B) Formulation Examples

[0417] a) A dust is obtained by mixing 10 parts by weight of a compound of the formula (G) and 90 parts by weight of talc as inert substance and comminuting the mixture in a hammer mill. [0418] b) A wettable powder which is readily dispersible in water is obtained by mixing 25 parts by weight of a compound of the formula (G), 64 parts by weight of kaolin-containing quartz as inert substance, 10 parts by weight of potassium lignosulphonate and 1 part by weight of sodium oleoylmethyltaurate as wetting agent and dispersant, and grinding the mixture in a pinned-disk mill. [0419] c) A readily water-dispersible dispersion concentrate is obtained by mixing 20 parts by weight of a compound of the formula (G) with 6 parts by weight of alkylphenol polyglycol ether (Triton X 207), 3 parts by weight of isotridecanol polyglycol ether (8 EO) and 71 parts by weight of paraffinic mineral oil (boiling range for example about 255 to above 277 C.) and grinding the mixture in a ball mill to a fineness of below 5 microns. [0420] d) An emulsifiable concentrate is obtained from 15 parts by weight of a compound of the formula (G), 75 parts by weight of cyclohexanone as solvent and 10 parts by weight of oxyethylated nonylphenol as emulsifier. [0421] e) Water-dispersible granules are obtained by mixing [0422] 75 parts by weight of a compound of the formula (G), [0423] 10 parts by weight of calcium lignosulphonate, [0424] 5 parts by weight of sodium laurylsulphate, [0425] 3 parts by weight of polyvinyl alcohol and [0426] 7 parts by weight of kaolin, [0427] grinding the mixture in a pinned-disk mill, and granulating the powder in a fluidized bed by spray application of water as a granulating liquid. [0428] f) Water-dispersible granules are also obtained by homogenizing and precomminuting [0429] 25 parts by weight of a compound of the formula (G), [0430] 5 parts by weight of sodium 2,2-dinaphthylmethane-6,6-disulphonate, [0431] 2 parts by weight of sodium oleoylmethyltaurinate, [0432] 1 part by weight of polyvinyl alcohol, [0433] 17 parts by weight of calcium carbonate and [0434] 50 parts by weight of water, [0435] on a colloid mill, subsequently grinding the mixture in a bead mill and atomizing and drying the resulting suspension in a spray tower by means of a single-substance nozzle.

[0436] Components which can be used in combination with the active compounds according to the invention in mixed formulations or in tank mix are, for example, known active compounds as they are described in, for example, Weed Research 26, 441-445 (1986), or The Pesticide Manual, 16th edition, The British Crop Protection Council and the Royal Soc. of Chemistry, 2006, and the literature cited therein, and which for example act as inhibitor of acetolactate synthase, acetyl-CoA-carboxylase, cellulose-synthase, enolpyruvylshikimat-3-phosphat-synthase, glutamin-synthetase, p-hydroxyphenylpyruvat-dioxygenase, phytoendesaturase, photosystem I, photosystem II, and/or protoporphyrinogen-oxidase.

(C) Biological Examples

[0437]

TABLE-US-00005 TABLE 1 PE Example Number Dosage Unit ECHCG SETVI AMARE VIOTR MATIN POLCO I-53 320 g/ha 100 100 100 100 100 100 I-44 320 g/ha 100 100 100 100 100 100 I-42 320 g/ha 100 100 100 100 100 100 I-55 320 g/ha 100 100 100 100 100 100 I-56 320 g/ha 100 100 100 100 90 100 I-45 320 g/ha 100 100 100 100 100 100 I-61 320 g/ha 100 100 100 100 100 100 I-43 320 g/ha 100 90 100 100 90 100 I-59 320 g/ha 100 100 100 100 100 100 I-69 320 g/ha 100 100 100 100 100 100 I-54 320 g/ha 100 100 100 100 100 100 I-71 320 g/ha 100 100 100 100 100 100 I-73 320 g/ha 100 100 100 100 100 100 I-72 320 g/ha 100 100 100 100 100 100 I-17 320 g/ha 100 100 100 100 100 100 I-63 320 g/ha 100 100 100 100 100 100 I-64 320 g/ha 100 100 100 100 100 90 I-67 320 g/ha 100 100 100 100 100 100 I-68 320 g/ha 100 100 100 100 100 100 I-75 320 g/ha 90 100 100 90 90 90 I-31 320 g/ha 90 100 100 100 100 100 I-83 320 g/ha 100 100 100 100 100 90 I-81 320 g/ha 100 90 100 100 100 100 I-76 320 g/ha 90 100 100 100 100 100 I-82 320 g/ha 100 100 100 100 100 100 I-57 320 g/ha 100 100 100 100 100 100 I-84 320 g/ha 100 100 100 100 100 100 I-85 320 g/ha 100 100 100 100 100 100 I-78 320 g/ha 100 100 100 100 100 100 I-77 320 g/ha 80 100 100 100 100 100 I-29 320 g/ha 100 100 100 100 100 100 I-58 320 g/ha 100 100 100 100 90 90

TABLE-US-00006 TABLE 2 PE Example Number Dosage Unit AMARE VIOTR ALOMY I-79 320 g/ha 100 100 100 I-07 320 g/ha 100 100 100 I-20 320 g/ha 100 100 80 I-18 320 g/ha 100 100 80 I-70 320 g/ha 100 100 100 I-06 320 g/ha 100 100 90

TABLE-US-00007 TABLE 3 PO Ex- am- ple Num- Dos- ber age Unit SETVI AMARE VIOTR ABUTH PHBPU I-17 320 g/ha 100 100 100 90 100 I-29 320 g/ha 100 100 100 80 80 I-85 320 g/ha 100 100 100 80 100 I-59 320 g/ha 100 100 100 100 100 I-68 320 g/ha 100 100 100 100 100 I-71 320 g/ha 100 100 100 100 100 I-53 320 g/ha 100 100 100 100 100 I-72 320 g/ha 90 100 90 100 100 I-61 320 g/ha 100 100 100 100 90 I-40 320 g/ha 90 100 100 100 100 I-84 320 g/ha 100 100 100 100 100 I-78 320 g/ha 100 100 100 80 100 I-07 320 g/ha 100 100 100 80 100 I-69 320 g/ha 100 100 100 90 100 I-70 320 g/ha 100 100 100 80 100 I-42 320 g/ha 100 100 100 80 100

TABLE-US-00008 TABLE 4 PO Example Number Dosage Unit AMARE VIOTR ABUTH I-79 320 g/ha 100 100 90 I-44 320 g/ha 100 100 100 I-55 320 g/ha 100 100 100 I-63 320 g/ha 100 100 100 I-73 320 g/ha 100 100 100 I-54 320 g/ha 100 90 100 I-76 320 g/ha 100 100 80 I-06 320 g/ha 100 100 100 I-57 320 g/ha 100 100 100 I-45 320 g/ha 100 90 100 I-64 320 g/ha 100 80 90 I-58 320 g/ha 100 100 90

Fungicidal Examples

[0438] 1) Example: In Vivo Preventive Test on Alternaria brassicae (Leaf Spot on Radish or Cabbage)

TABLE-US-00009 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0439] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0440] The young plants of radish or cabbage were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0441] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Alternaria brassicae spores. The contaminated radish or cabbage plants were incubated for 6 days at 20 C. and at 100% relative humidity.

[0442] The test was evaluated 6 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0443] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: 1-12; 1-14; 1-41; 1-42; 1-44; 1-45; 1-53; 1-54; 1-55; 1-56; I-57; 1-58; 1-59; 1-61; 1-63; 1-64; 1-65; 1-85

[0444] 2) Example: In Vivo Preventive Test on Botrytis cinerea (Grey Mould)

TABLE-US-00010 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0445] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0446] The young plants of gherkin were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0447] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Botrytis cinerea spores. The contaminated gherkin plants were incubated for 4 to 5 days at 17 C. and at 90% relative humidity.

[0448] The test was evaluated 4 to 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0449] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-01; I-02; I-04; I-29; I-30; I-31; I-41; I-42; I-43; I-77; I-81; I-82

[0450] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: 1-59; 1-78

[0451] 3) Example: In Vivo Preventive Test on Phytophthora infestans (Tomato Late Blight)

TABLE-US-00011 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0452] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0453] The young plants of tomato were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0454] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Phytophthora infestans spores. The contaminated tomato plants were incubated for 5 days at 16-18 C. and at 100% relative humidity.

[0455] The test was evaluated 5 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0456] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: I-02; I-03; I-04; I-09; I-11; I-13; I-14; I-15; I-18; I-20; I-24; I-29; I-40; I-46; I-51; I-52; I-60; I-62; I-63; I-65; I-66; I-67; I-68; I-69; I-70; I-71; I-72; I-73; I-77; I-78; I-81; I-82; I-83; I-86

[0457] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-01; I-06; I-07; I-12; I-17; I-30; I-31; I-41; I-42; I-43; I-45; I-53; I-54; I-55; I-56; I-57; I-58; I-59; I-61; I-64; I-76; I-79; I-84; I-85

[0458] 4) Example: In Vivo Preventive Test on Puccinia recondita (Brown Rust on Wheat)

TABLE-US-00012 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0459] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0460] The young plants of wheat were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0461] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Puccinia recondita spores. The contaminated wheat plants were incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

[0462] The test was evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0463] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: 1-12; I-14; I-15; I-17; I-30; I-31; I-40; I-41; I-42; I-43; I-44; I-53; I-54; I-55; I-59; I-61; I-63; I-64; I-69; I-71; I-72; I-84; I-85

[0464] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-07

[0465] 5) Example: In Vivo Preventive Test on Pyrenophora teres (Net Blotch on Barley)

TABLE-US-00013 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0466] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0467] The young plants of barley were treated by spraying the active ingredient prepared as described above.

[0468] Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0469] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Pyrenophora teres spores. The contaminated barley plants were incubated for 48 hours at 20 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

[0470] The test was evaluated 14 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0471] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: 1-01; I-07; I-08; I-12; I-17; I-18; I-20; I-24; I-31; I-55; I-61; I-82

[0472] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-44 [0473] 6) Example: in vivo preventive test on Septoria tritici (leaf spot on wheat)

TABLE-US-00014 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0474] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0475] The young plants of wheat were treated by spraying the active ingredient prepared as described above.

[0476] Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0477] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Septoria tritici spores. The contaminated wheat plants were incubated for 72 hours at 18 C. and at 100% relative humidity and then for 21 days at 20 C. and at 90% relative humidity.

[0478] The test was evaluated 24 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0479] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: 1-02; I-04; I-08; I-09; I-10; I-11; I-12; I-14; I-15; I-16; I-18; I-20; I-40; I-41; I-47; I-48; I-51; I-52; I-56; I-57; I-58; I-60; I-67; I-70; I-77; I-81; I-83; I-85 In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: 1-06; I-07; I-17; I-19; I-21; I-42; I-43; I-45; I-50; I-59; I-68; I-71; I-72; I-73; I-79; I-82; I1-84

[0480] 7) Example: In Vivo Preventive Test on Sphaerotheca Fuliqinea (Powdery Mildew on Cucurbits)

TABLE-US-00015 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0481] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0482] The young plants of gherkin were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0483] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Sphaerotheca fuliginea spores. The contaminated gherkin plants were incubated for 72 hours at 18 C. and at 100% relative humidity and then for 12 days at 20 C. and at 70-80% relative humidity.

[0484] The test was evaluated 15 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0485] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: 1-01; I-12; I-14; I-15; I-45; I-46; I-52; I-54; I-56; I-58; I-64; I-68 In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: 1-07; I-17; I-55; I-57; I-59; I-63; I-67; I-69; I-70; I-71; I-72; I-73; I-76; I-78; I-81

[0486] 8) Example: In Vivo Preventive Test on Uromyces appendiculatus (Bean Rust)

TABLE-US-00016 Solvent: 5% by volume of Dimethyl sulfoxide 10% by volume of Acetone Emulsifier: 1 l of Tween 80 per mg of active ingredient

[0487] The active ingredients were made soluble and homogenized in a mixture of Dimethyl sulfoxide/Acetone//Tween 80 and then diluted in water to the desired concentration.

[0488] The young plants of bean were treated by spraying the active ingredient prepared as described above. Control plants were treated only with an aqueous solution of Acetone/Dimethyl sulfoxide/Tween 80.

[0489] After 24 hours, the plants were contaminated by spraying the leaves with an aqueous suspension of Uromyces appendiculatus spores. The contaminated bean plants were incubated for 24 hours at 20 C. and at 100% relative humidity and then for 10 days at 20 C. and at 70-80% relative humidity.

[0490] The test was evaluated 11 days after the inoculation. 0% means an efficacy which corresponds to that of the control plants while an efficacy of 100% means that no disease was observed.

[0491] In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 500 ppm of active ingredient: 1-06; I-07; I-12; I-17; I-29; I-30; I-40; I-41; I-42; I-43; I-53; I-54; I-55; I-57; I-59; I-63; I-64; I-69; I-85 In this test, the following compounds according to the invention showed efficacy of at least 70% at a concentration of 100 ppm of active ingredient: I-61