System and method for the controlled transport of biological samples

Abstract

The system comprises a container including a main body (3), a cover (2), an opening/closure control device for controlling the opening/closure of the container (1), a temperature sensor and an electronic board configured for collecting data acquired by said temperature sensor and for controlling a state and operation of said opening/closure control device, wherein the system further comprises a server (21) including a database; the container (1) further includes a biological sample content detector controlled by said electronic board; and the electronic board includes a communication module configured for sending to said server (21), during transport, a series of data that is at least about the content of the container (1) and the internal temperature thereof, for the storage of said series of data in the database of the server (21).

Claims

1. A system for the controlled transport of biological samples, comprising: a server (21) including a database; a container (1) for storing biological samples including; a main body (3) defining a housing cavity; a cover (2); an opening/closure control device for controlling the opening/closure of the container (1); at least one temperature sensor configured for providing information about the internal temperature of the container (1) from an instant of loading said biological samples in the container (1) to a subsequent instant of opening the container (1) and/or extracting the biological samples from the container (1); and an electronic board configured for collecting data acquired by said at least one temperature sensor, and for controlling a state and operation of said opening/closure control device, wherein the electronic board includes a communication module configured for sending to said server (21), during transport, a series of data for the storage of said series of data in the database of the server (21); wherein: the system further includes two different RFID tags (40, 41), wherein a first RFID tag (40) includes data of a center of origin and a second RFID tag (41) includes data of a center of destination of the container (1) as well as type of biological sample to be transported; the opening/closure control device comprises an electromechanical device which is activated using the RFID tags (40, 41); the container (1) further includes: a RFID reader that is configured to read data of said different RFID tags (40, 41) at a given configured period of time; a detector of biological samples within the container (1) controlled by said electronic board; wherein said detector of biological samples is a proximity sensor selected from infrared, capacitive or inductive detector, the proximity sensor being configured for detecting the presence of the biological samples transported inside the container (1) from the instant of loading the biological samples in to the instant of extracting the biological samples from the container (1), and wherein the series of data send by the electronic board comprises data about the content of the container (1) acquired by the detector and data about the internal temperature of the container (1).

2. The system according to claim 1, wherein said biological samples are held within a secondary container (14) arranged inside the container (1).

3. The system according to claim 2, wherein the secondary container (14) is made of a transparent or translucid material and further comprises a label, plate or texturized zone (25) to cooperate with the proximity sensor.

4. The system according to claim 1, wherein the opening/closure control device is included in the cover (2).

5. (canceled)

6. The system according to claim 1, further comprising a mobile computing device (20) with wireless communication with said communication module and with the RFID reader via a mobile application installed therein, wherein said mobile computing device (20) being used at the origin to validate the data and center of origin associated to the container (1) and at destination to validate the data and center of destination and to activate the RFID reader, the system further including a warning unit to emit an alarm in case of error.

7. The system according to claim 1, further comprising a display unit (5) controlled by the electronic board for indicating distinct information about the content of the container (1) that is at least related with the transported biological samples wherein said display unit comprising a screen and/or light-emitting indicators.

8. The system according to claim 1, wherein the container (1) further comprises one or more batteries for self-powering of the electronic, board.

9. The system according to claim 1, wherein the container (1) further comprises at least one accelerometer configured for detecting sudden movements of the container (1) during transport or handling.

10. The system according to claim 1, further comprising a computing device (20), including a mobile telephone or a tablet, located in the proximity of the container (1), during transport, said computing device (20) comprising positioning means operatively connected to the server (21), to allow tracking positioning data of the container (1) during transport.

11. A method for the controlled transport of biological samples in a container, wherein said container (1) comprises: a main body (3) defining a housing cavity; a cover (2); a RFID reader; an opening/closure control device for controlling the opening/closure of the container (1), wherein the opening/closing control device comprises an electromechanical device; at least one temperature sensor providing information about the internal temperature of the container (1) from an instant of loading the biological samples in the container (1) to a subsequent instant of opening the container (1) and/or extracting the biological samples from the container (1); and an electronic board configured for collecting the data acquired by at least said temperature sensor and for controlling a state and operation of said opening/closure control device; the method comprising the following steps: reading by the RFID reader data from the at least two different RFID tags (40, 41) at a given configured period of time, wherein a first RFID tag (40) includes data of a center of origin and a second RFID tag (41) includes data of center of destination of the container (1) as well as type of biological sample to be transported; detecting, by means of a detector of biological samples controlled by said electronic board, the existence of a biological sample load in the container (1); wherein said detector of biological samples is a proximity sensor selected from infrared, capacitive or inductive detector, the proximity sensor being configured for detecting the presence of the biological samples transported inside the container (1) from the instant of loading the biological samples in to the instant of extracting the biological samples from the container (1), sending to a server (21), by means of a communication module included in the electronic board, a series of data about the internal temperature of the container (1), the content and incidences of opening/closing the container (1) and/or incidences related with content handling; and storing said series of received data and time instants of said incidences of opening/closing the container (1) in a database of the server (21), wherein said data stored in said database constitutes a control and/or supervision record.

12. The method according to claim 11, further comprising emitting a warning signal if the content detector continues to detect content after extracting the biological samples from the container (1) and/or emitting a warning signal if the temperature of the container (1) is the same as or exceeds a pre-established threshold temperature value during transport.

13. The method according to claim 11, wherein said sending of the series of data is performed every certain configurable period of time.

14. (canceled)

15. The method according to claim 11, further comprising tracking positioning data of the container (1) from an instant of closing the container (1) to an instant of opening the container (1), during transport, using positioning means of a mobile computing device (20) operatively connected to the server (21), said mobile computing device (20) further being used by means of a mobile application installed therein for validating at an origin the data of RFID tag (40) and center of origin associated to the container (1) and at a destination to validate the data of RFID tag (41) and center of destination of the container (1) and to activate the RFID reader, the system further including a warning unit to emit an alarm in case of error.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The foregoing and other advantages and features will be more clearly understood based on the following detailed description of several illustrative and non-limiting embodiments in reference to the attached drawings, in which:

[0029] FIG. 1 schematically shows an embodiment of a system for the controlled transport of biological samples with detail of the scenario and basic intervening agents

[0030] FIGS. 2a to 2d show different views of an embodiment of the container for transporting biological samples proposed by the present invention.

[0031] FIGS. 3a and 3b illustrate a detail of the elements constituting the closing device of the container.

[0032] FIGS. 4a and 4b show a possible embodiment of a secondary container for the biological samples, vaccines or drugs, used in the system.

[0033] FIGS. 5a and 5b are two schematic views illustrating the detection of the secondary container inside the main container, with a proximity detector.

[0034] FIG. 6 shows an embodiment of the display unit of the container of FIG. 2.

[0035] FIG. 7 is a flow chart describing in detail an embodiment of a method for the controlled transport of biological samples in a container according to this invention.

DETAILED DESCRIPTION OF SEVERAL EMBODIMENTS

[0036] FIG. 1 illustrates an embodiment of a system for the controlled transport of biological samples. According to this embodiment, the system comprises a container 1 for storing and transporting biological samples, for example blood samples, vaccines, or drugs among others, including a communication module; a server 21 operatively connected to the mentioned container 1 through a communications network such as the Internet; a computing device 20 such as a mobile telephone, preferably belonging to the operator (not illustrated for simplicity of the drawing) in charge of transporting the biological samples, and at least two RFID tags 40, 41. The positioning means, for example GPS, integrated in the computing device 20 itself can therefore be used to allow tracking the positioning data of the container 1 in the transportation route.

[0037] The system shown in the figure includes two different RFID tags 40, 41, and the container 1 further includes a RFID reader that is configured to read data of said different RFID tags 40, 41 at a given configured period of time, wherein a first RFID tag 40 includes data of a center of origin and a second RFID tag 41 includes data of a center of destination of the container 1 as well as type of biological sample to be transported.

[0038] The mobile computing device 20 with wireless communication with the communication module of the container 1, via a mobile application installed therein, is further used at the origin to validate the data and center of origin associated to the container 1 and at destination to validate the data and center of destination and to activate the RFID reader, the system further including a warning unit to emit an alarm in case of error. On this way the electronic components installed in the container 1 can be in stand-by state during transport of the container except during the periods in which they transmit data to the server 21, and are woken up at destination just before authorized personnel approach the container 1 with a RFID tag 41 to open the container 1.

[0039] Alternatively, the server 21 could be a cloud server.

[0040] FIGS. 2a to 2d illustrates an embodiment of the container 1 proposed by the present invention. The container 1 consists of a rigid outer body (or main body) 3 manufactured in plastic materials with an inner foam body (preferably 4 cm thick) conferring it with insulating capacity for keeping the cold. The container 1 has an upper cover 2 fixed with hinges 4. The cover 2 is assembled to the main body 3 of the container 1, generating a leak-tight inner space. To assure leak-tightness, there is a plastic profile both in the upper part of the main body 3 and in the lower part of the cover 2 fitting with one another and incorporating a rubber profile which, when the cover 2 is closed, act as a sealing gasket and make it leak-tight. The container 1 can also include metal hooks on the sides of the main body 3 for holding a strap making it easier to transport the container 1. Likewise, the main body 3 can include on one of its inner sides an elastic band held by rivets fixed at each end which allows holding a folder containing information about the biological samples transported in the container 1. The container further includes a handle portion 7 (in the example an adjusting strap) and fixing elements 7a at both ends of the handle.

[0041] The inside of the container 1 is lined with a white rigid body of the same material as the outside thereof in order to make it leak-tight and to convert it into a leak-tight space. Preferably, the inner area is sized for storing four racks of biological samples housed inside a secondary container 14 (see FIGS. 4a and 4b for a possible embodiment, and 5a and 5b showing the arrangement of secondary container 14 inside main container (1) manufactured preferably in a plastic, transparent material, with an opaque cover, in addition to another secondary container having the same or less height for storing different biological samples. The inner area also includes a temperature sensor (not illustrated). The temperature sensor, more than one can be included, provides information about the internal temperature of the container 1 from an instant of loading the biological samples in the container 1 to the instant of opening the container 1 and/or extracting the biological samples from the container 1. The inner area can also include a humidity sensor for providing information about the humidity inside the container 1.

[0042] The container 1 also includes an electronic board and a content detector (also not illustrated). The electronic board incorporates the mentioned communication module, for example a GSM or UMTS module, for establishing the mentioned communication with the server 21, sending to said server 21 at least the data about the temperature acquired by the temperature sensor and by the content detector for the storage thereof in its database, or memory.

[0043] Likewise, the mentioned cover 2 of the container 1 includes, partly illustrated in FIGS. 3a and 3b, an opening/closure control device for controlling the opening/closure of the container 1. The opening/closure control device preferably comprises an electromechanical device 31 configured, together with the mentioned electronic board, for being activated by means of at least two RFID sensors 40, 41 depending on the type of biological samples to be transported and location (origin or destination). In other words, if the biological samples to be transported are blood samples a first RFID 40, 41 sensors will be used and if the biological samples to be transported are vaccines a second RFID 40, 41 sensors will be used. The cover 2 can also include hooks holding a net which allows holding a series of cold packs, depending on the needs of each case. FIG. 3a also includes a detail of a magnet 12 to be use in conjunction with a Hall detector for the closure. A latch 30 is also indicated cooperating with another latch in the cover 2. The frame 11 of FIG. 3a is arranged within a housing of frame 13.

[0044] The electronic board comprises one or more microprocessors for operating/controlling the different peripherals/elements of the container 1: display unit 5, RFID identification system for identifying the type of RFID tag or cards 40, 41 indicating origin, destination and biological samples and the users/operators, communication module, content detector, opening/closure control device, temperature sensor, as well as for accommodating supply voltages for the different peripherals/elements, etc.

[0045] The content detector is preferably a photoelectric proximity sensor 35 that works by means of infrared. Nevertheless, other proximity sensors can likewise be used for said functionality, for example capacitive or inductive sensors.

[0046] FIGS. 5a and 5b show how the secondary container 14 is detected inside the main container 1, by means of a proximity detector 35. The secondary container as seen in FIGS. 4a and 4b, will be made of a transparent or translucid material but having a plate or label 25 that allow a proximity sensor such as an infrared sensor to be operative.

[0047] The container 1 further includes one or more batteries for self-powering of the electronic board.

[0048] In the embodiment described in FIGS. 2a to 2d, the display unit 5 comprises a screen, for example a TFT screen. The display unit can be tilted to thereby allow viewing same from different angles. The display unit 5 incorporates a push-button 6 activating the light of the screen 5 at the user's/operator's demand for consulting the data appearing thereon.

[0049] FIG. 6 shows an embodiment of the mentioned screen. As can be seen in FIG. 6, the screen shows data 15 relating to the internal temperature of the container 1, to the remaining percentage of battery 16, to the medical/health center of origin of the biological samples and the center of destination of the biological samples 17, to the type of samples 18 (in this particular case, blood samples, as seen in the text and in the symbol of a drop of blood, it must be pointed out that for other types of samples other symbols will be used (for example a cross to indicate vaccines)) and to the time elapsed during transport 19 (from the closure of the container to the opening thereof in the center of destination). The upper area of the screen includes the reading area of the RFID sensors 9, the identification number 10 of the container 1 and the mentioned push-button 6. The lower area of the screen includes a LED 8 which changes color depending on whether the container is full or empty (preferably, red if the container 1 is full and green if it is empty).

[0050] The mentioned screen 5 can also be automatically activated, i.e., the screen 5 can be configured to light up for specific time period.

[0051] In an alternative embodiment, the container 1 can include two optoelectronic components, such as LEDs of different colors, to distinctly indicate whether the container 1 is full or empty.

[0052] Optionally, the container 1 can include an accelerometer for detecting sudden movements of the container 1 during transport or handling.

[0053] Now, in reference to FIG. 7, said figure shows an embodiment of a method for the controlled transport of biological samples in a container, such as the one described above. The method comprises first validating data of RFID tag 40 and center of origin at origin, S401 and detecting, step 402, by means of the mentioned content detector, the existence of a biological sample load in the secondary container 14 within the container 1. Then, the method comprises sending to the server 21, step 403, by means of the mentioned communication module included in the electronic board of the container 1, every certain configurable period of time, a series of data at least relating to: the internal temperature of the container 1, the content and incidences of opening/closing the container 1. Finally, the method stores, step 404, the series of received data and the time instants of said incidences of opening/closing the container 1 in a database of the server 21, wherein the data stored in the database constitutes a control and/or supervision record. Finally, on step 405 data of RFID tag 40 and center of destination are validated.

[0054] Likewise, the mentioned communication module can also send information relating to the state of the battery/batteries, the medical/health center of origin of the biological samples, the route taken, the identifier of the container 1, the user/operator identifier, in addition to other information memorized in the RFID sensors that may be personalized as required, for example, incidences occurring during transport, such as the wait time, if the container 1 has broken, if an accident has occurred in the route taken, the traffic condition in the route taken, etc.

[0055] In one embodiment, the method emits a warning signal if the content detector detects content inside the container 1 once the biological samples have been extracted therefrom. It is thereby assured that all the transported biological samples are extracted in the medical/health center of destination.

[0056] Furthermore, if the internal temperature of the container 1 is the same as or exceeds a pre-established threshold temperature value during transport, for example 23 degrees for blood samples or 8 degrees for vaccines, a warning signal can be emitted, said emitted warning signal being recorded in the server 21.

[0057] The method allows tracking positioning data of the container 1 from the instant of closing to the instant of opening same, during transport. The mentioned positioning means of the computing device 20 are preferably used for such purpose. Nevertheless, a positioning sensor could be alternatively included in the container 1. The container 1 itself, without having to use the computing device 20, will thereby allow tracking the positioning data of the container 1 during transport.

[0058] As improvements of the present invention, the present invention can also provide a mobile application, or an APP, run in the computing device 20 or in another computing device, providing through a user interface the same information as the data stored in the mentioned database (internal temperature of the container, content, incidences, state of the battery/batteries, etc.).

[0059] By means of cited APP running in the computing device 20 it is also possible that one or several containers being automatically open when arriving to the destination, as detected by the computing device 20 of the carrier at that place.

[0060] Secondary container 14 illustrated in FIGS. 4a and 4b, comprises a body 24 which integrates in a side wall a plate 25, and further comprising a lid 22 with a watertight element 23. The lid further including fixing appendixes 22a to be coupled to protrusions 24a of the body 24. Likewise, the container 1 complies with UN 3373 guidelines in force on the date of filing of this document.

[0061] The scope of the present invention is defined in the attached claims.