Tooth-attachable patch capable of being removed by tooth brushing

Abstract

The present invention relates to a tooth-attachable patch comprising: a drug layer for delivering drugs to a tooth; and a backing layer positioned on the opposite side of a tooth attachment surface of the drug layer, and including, both a water-soluble polymer and a water-insoluble polymer. The patch of the present invention can be easily removed by merely brushing the teeth without separately stripping off a backing layer.

Claims

1. A patch for attaching to teeth or a surrounding part of teeth, which comprises: a drug layer for delivering drugs to teeth; and a backing layer positioned on the opposite side of a tooth attachment surface of the drug layer, and including both a water-soluble polymer and a water-insoluble polymer, wherein a weight ratio of the water-soluble polymer to the water-insoluble polymer included in the backing layer is 1:4 to 4:1.

2. The patch for attaching to teeth or a surrounding part of teeth of claim 1, wherein the water-soluble polymer comprises at least one selected from the group consisting of polyalkyl vinyl ether-maleic acid copolymer, polyvinyl alcohol, polyacrylic acid, poloxamer 407, polyethyleneoxide, polyvinyl pyrrolidone-vinyl acetate copolymer, polyvinyl pyrrolidone, polyquaternium-11, polyquaternium-39, carboxypolymethylene, hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, starch, gelatin, and sodium alginate.

3. The patch for attaching to teeth or a surrounding part of teeth of claim 2, wherein the water-soluble polymer is hydroxypropyl methyl cellulose, polyvinyl pyrrolidone or a mixture thereof.

4. The patch for attaching to teeth or a surrounding part of teeth of claim 1, wherein the drug layer comprises at least one selected from the group consisting of ingredients for whitening teeth, ingredients for preventing or improving sensitive teeth, ingredients for preventing cavities, and ingredients for preventing periodontal disease.

5. The patch for attaching to teeth or a surrounding part of teeth of claim 4, wherein the ingredients for whitening teeth are: at least one peroxide selected from the group consisting of hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, tetrasodium pyrophosphate peroxidate and a mixture thereof; at least one polyphosphate selected from the group consisting of tetrasodium pyrophosphate, sodium acid pyrophosphate, sodium hexametaphosphate, sodium tripolyphosphate, sodium potassium tripolyphosphate, tetrapotassium pyrophosphate, ultra-metaphosphate as ultra-phosphate, acidic sodium polyphosphate, and a mixture thereof; or a mixture thereof.

6. The patch for attaching to teeth or a surrounding part of teeth of claim 4, wherein the ingredients for preventing or improving sensitive teeth or cavities are at least one selected from the group consisting of strontium chloride, calcium carbonate, sodium citrate, sodium fluoride, silica, hydroxyapatite, potassium nitrate, and potassium phosphate.

7. The patch for attaching to teeth or a surrounding part of teeth of claim 1, wherein the patch is capable of being degraded by tooth brushing, wherein a dry weight of the residue of the patch filtered through a 1 mm mesh after brushing the patch for 3 min at a rate of 90 times per min back and forth at a load of 250 g is less than 2 wt % based on the total weight of the backing layer before brushing.

8. The patch for attaching to teeth or a surrounding part of teeth of claim 1, wherein the backing layer has a breakable portion.

9. The patch for attaching to teeth or a surrounding part of teeth of claim 8, wherein the breakable portion includes prominence and depression or bubbles.

10. The patch for attaching to teeth or a surrounding part of teeth of claim 9, wherein the prominence and depression has a concave portion in a depth of more than 0 m and 30 m or less based on a convex portion.

11. The patch for attaching to teeth or a surrounding part of teeth of claim 9, wherein the prominence and depression has a concave portion in a width of more than 0 mm and 0.1 mm or less.

12. A patch for attaching to teeth or a surrounding part of teeth, which comprises: a drug layer for delivering drugs to teeth; and a backing layer positioned on the opposite side of a tooth attachment surface of the drug layer, and including a water-insoluble polymer and hydroxypropyl methyl cellulose (HPMC), wherein the backing layer is capable of being degraded by tooth brushing.

13. The patch for attaching to teeth or a surrounding part of teeth of claim 12, wherein the water-insoluble polymer is at least one selected from the group consisting of cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine/methacrylate copolymer, methacrylic acid copolymer, and aminoalkyl methacrylate copolymer.

14. The patch for attaching to teeth or a surrounding part of teeth of claim 12, wherein the water-insoluble polymer is ethyl cellulose.

15. The patch for attaching to teeth or a surrounding part of teeth of claim 12, wherein a weight ratio of the water-insoluble polymer to the HPMC included in the backing layer of the patch is 1:0.2 to 4.

16. The patch for attaching to teeth or a surrounding part of teeth of claim 12, wherein a dry weight of the residue of the patch filtered through a 500 m mesh after brushing the patch for 3 min at a rate of 90 times per min back and forth at a load of 250 g is less than 5 wt % based on the total weight of the backing layer before brushing.

17. The patch for attaching to teeth or a surrounding part of teeth of claim 12, wherein the backing layer has a breakable portion.

18. The patch for attaching to teeth or a surrounding part of teeth of claim 12, wherein the breakable portion includes prominence and depression or bubbles.

Description

DESCRIPTION OF DRAWINGS

(1) Other objects and aspects of the present invention will become apparent from the following descriptions of the embodiments with reference to the accompanying drawings in which:

(2) The accompanying drawings illustrate a preferred embodiment of the present invention and together with the foregoing disclosure, serve to provide further understanding of the technical spirit of the present invention, and thus, the present invention is not construed as being limited to the drawing.

(3) FIG. 1 shows the result of the survey for the convenience of removal of the patches of Comparative Examples and Examples. As can be seen from FIG. 1, higher score was obtained from users who used the patches of Examples.

(4) FIG. 2 is a drawing prefiguratively showing the tooth-attachable patch 1 of the present invention. As prefiguratively shown in FIG. 2a, the patch may include a drug layer 10 and a backing layer 20, and as shown in FIG. 2b, the patch may include another layer separately between the drug layer 10 and the backing layer 20 depending on its purpose.

(5) FIG. 3 is a graph showing the result of evaluating removability of the patches of Table 5 and Table 6.

(6) FIG. 4 is a graph showing the result of evaluating removability of the patch including a breakable portion and the patch not including a breakable portion of the present invention.

(7) FIG. 5 is a drawing prefiguratively showing the patch 1 including a breakable portion 30 of the present invention.

(8) FIG. 6 is a drawing prefiguratively showing an example that the breakable portion 30 includes prominence and depression 31 in the patch 1 including the breakable portion 30 of the present invention.

(9) FIG. 7 a drawing prefiguratively showing an example that the breakable portion 30 includes a bubble 32 in the patch 1 including the breakable portion 30 of the present invention.

BEST MODE

(10) Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to the description, it should be understood that the terms used in the specification and the appended claims should not be construed as limited to general and dictionary meanings, but interpreted based on the meanings and concepts corresponding to technical aspects of the present invention on the basis of the principle that the inventor is allowed to define terms appropriately for the best explanation. Therefore, the description proposed herein is just a preferable example for the purpose of illustrations only, not intended to limit the scope of the disclosure, so it should be understood that other equivalents and modifications could be made thereto without departing from the scope of the disclosure.

MODE FOR DISCLOSURE

Preparative Example 1

(11) <Preparation of Patch for Tooth Whitening>

(12) Patches for tooth whitening of Comparative Examples having composition of the following Table 1 and Patches for tooth whitening of Examples having composition of the following Table 2 were prepared according to the method for preparing a backing layer and a drug reservoir layer in Preparative Example 1 of Korean Patent No. 10-0816250.

(13) TABLE-US-00001 TABLE 1 Comparative Example 1 Comparative Example 2 Drug Hydrogen peroxide 2.9% Hydrogen peroxide 2.9% layer Povidone 19.0% Povidone 19.0% Glycerin 3.0% Glycerin 3.0% Pullulan 1.0% Pullulan 1.0% SPAN80 5.0% SPAN80 5.0% Water etc. to 100% Water etc. to 100% Backing Ethyl Cellulose 15.0% Povidone 15.0% layer Castor oil 10.0% glycerin 3.0% Ethanol etc. to 100% Pullulan 1.0% Water etc. to 100%

(14) TABLE-US-00002 TABLE 2 Example 1 Example 2 Example 3 Example 4 Drug Hydrogen peroxide 2.9% Hydrogen peroxide 2.9% Hydrogen peroxide 2.9% Hydrogen peroxide 2.9% layer Povidone 19.0% Povidone 19.0% Povidone 19.0% Povidone 19.0% Glycerin 3.0% Glycerin 3.0% Glycerin 3.0% Glycerin 3.0% Pullulan 1.0% Pullulan 1.0% Pullulan 1.0% Pullulan 1.0% SPAN80 5.0% SPAN80 5.0% SPAN80 5.0% SPAN80 5.0% Water etc. to 100% Water etc. to 100% Water etc. to 100% Water etc. to 100% Backing Ethyl Cellulose 12.0% Ethyl Cellulose 3.0% Ethyl Cellulose 12.0% Ethyl Cellulose 3.0% layer Hydroxypropyl 3.0% Hydroxypropyl 12.0% Povidone 3.0% Povidone 12.0% methylcellulose methylcellulose Castor oil 15.0% Castor oil 5.0% Castor oil 15.0% Castor oil 5.0% SPAN80 5.0% SPAN80 15.0% SPAN80 5.0% SPAN80 15.0% Ethanol etc. to 100% Ethanol etc. to 100% Ethanol etc. to 100% Ethanol etc. to 100%

(15) TABLE-US-00003 TABLE 3 Example 5 Example 6 Drug Potassium phosphate monobasic 2.0% Bamboo salt 3.0% layer Potassium phosphate dibasic 3.0% Titrated Extract of Zea Mays L. 0.5% unsaponifiable fraction Povidone 19.0% Povidone 19.0% Glycerin 3.0% Glycerin 3.0% Pullulan 1.0% Pullulan 1.0% SPAN80 5.0% SPAN80 5.0% Water etc. to 100% Water etc. to 100% Backing Ethyl Cellulose 6.0% Ethyl Cellulose 7.0% layer Hydroxypropyl methylcellulose 8.0% Hydroxypropyl methylcellulose 8.0% Castor oil 15.0% Castor oil 5.0% SPAN80 5.0% SPAN80 15.0% Ethanol etc. to 100% Ethanol etc. to 100%

(16) <Survey for Removability>

(17) Survey for removal convenience was conducted to patches of Comparative Example 1 and Examples 1 to 6 which need a removal process after use, except a patch of Comparative Example 2 which melts away during use. Each of the patches of Comparative Example 1 and Examples 1 to 6 was attached to 30 responders for 15 min according to the group, and then the patch of Comparative Example 1 or Examples 1 to 6 was removed by tooth brushing. Then, each group changed the products and then responded to a questionnaire for removal convenience.

(18) Criteria for Survey Response

(19) 5: Removal is very convenient and there is no clotting in a toothbrush.

(20) 4: Removal is convenient but there is little residue in a toothbrush.

(21) 3: Removal is inconvenient and there is inconvenience due to residue in a toothbrush.

(22) 2: Removal is inconvenient and there are many residues in a toothbrush.

(23) 1: Removal is very inconvenient and there are so many residues in a toothbrush.

(24) As can be seen from FIG. 1, in the case of Comparative Example 1, the majority of investigators evaluated that there were many lumpy residues in the toothbrush and removal was very inconvenient. However, the majority of investigators used the patches of Examples of the present invention evaluated that removal by tooth brushing was convenient and there was little residue.

(25) It was confirmed that the tooth patch of the present invention was conveniently removed when removed by tooth brushing after use and the toothbrush was clean without lumping and clotting.

(26) <Evaluation of Degradation by Tooth Brushing>

(27) Two sets of Comparative Example 1 and Examples 1 to 6 were prepared. Each patch of one set was shaken in distilled water for 30 min to leave only a backing layer, dried and then weight of the patch was measured. Each patch of the other set was attached to a slide glass, stored in 37 C., 85% humidity environment for 30 min, and then brushed for 3 min using a brushing machine at a rate of 90 times per min back and forth at a load of 250 g. Then, the slide glass, the brushing chamber and the toothbrush were separated, and washed with distilled water while collecting the washing solution. The collected washing solution was filtered through a 1 mm-mesh sieve, and residue was dried and weighed to calculate a ratio of the residue based on the total weight of the backing layer.

(28) TABLE-US-00004 TABLE 4 Comparative Exam. Exam. Exam. Exam. Exam. Exam. Exam. 1 1 2 3 4 5 6 Residue 98.6 1.6 0.8 1.9 0.6 0.5 0.4 ratio (wt %)

(29) As can be seen from Table 4, it was confirmed that the patch of Comparative Example has a residue ratio of 98% or more, which is hardly degraded by tooth brushing. However, it was confirmed that the patch of the present invention having a backing layer including a water-soluble polymer has a residue ratio of less than 2%, which is mostly degraded by tooth brushing.

Preparative Example 2

(30) <Preparation of Patch for Tooth Whitening>

(31) Patches for tooth whitening of Comparative Examples having composition of the following Table 5 and Patches for tooth whitening of Examples having composition of the following Table 5 and Table 6 were prepared.

(32) TABLE-US-00005 TABLE 5 Comparative Example 3 Example 7 Example 8 Drug Hydrogen peroxide 2.9% Hydrogen peroxide 2.9% Hydrogen peroxide 2.9% layer Povidone 19.0% Povidone 19.0% Povidone 19.0% Glycerin 3.0% Glycerin 3.0% Glycerin 3.0% Pullulan 1.0% Pullulan 1.0% Pullulan 1.0% Water etc. to 100% Water etc. to 100% Water etc. to 100% Backing Ethyl Cellulose 20.0% Ethyl Cellulose 10.0% Ethyl Cellulose 10.0% layer Povidone 10.0% Poloxamer 10.0% SPAN80 5.0% SPAN80 5.0% Castor oil 10.0% Castor oil 5.0% Castor oil 5.0% Ethanol etc. to 100% Ethanol etc. to 100% Ethanol etc. to 100%

(33) TABLE-US-00006 TABLE 6 Example 9 Example 10 Example 11 Drug Hydrogen peroxide 2.9% Potassium phosphate monobasic 2.0% Bamboo salt 3.0% layer Potassium phosphate dibasic 3.0% Titrated Extract of Zea Mays 0.5% L. unsaponifiable fraction Povidone 19.0% Povidone 19.0% Povidone 19.0% Glycerin 3.0% glycerin 3.0% glycerin 3.0% Pullulan 1.0% Pullulan 1.0% Pullulan 1.0% SPAN80 5.0% SPAN80 5.0% Water etc. to 100% Water etc. to 100% Water etc. to 100% Backing Ethyl Cellulose 10.0% Ethyl Cellulose 6.0% Ethyl Cellulose 7.0% layer HPMC 2910 10.0% HPMC 2910 8.0% HPMC 2910 8.0% SPAN80 5.0% Castor oil 15.0% Castor oil 5.0% Castor oil 5.0% SPAN80 5.0% SPAN80 15.0% Ethanol etc. to 100% Ethanol etc. to 100% Ethanol etc. to 100% *HPMC: HYDROXYPROPYL METHYLCELLULOSE

(34) Patches for tooth whitening having composition of Table 5 and Table 6 were prepared according to the method for preparing a backing layer and a drug reservoir layer in Preparative Example 1 of Korean Patent No. 10-0816250. HPMC (AN6 from Samsung fine chemical Co., Ltd) used in Examples 9 to 11 was 2910 and its viscosity type was 6 cPs.

(35) <Survey for Removability>

(36) Survey for removal convenience was conducted to patches of Comparative Example 3 and Examples 7 to 11. Each of the patches of Comparative Example 3 and Examples 7 to 11 was attached to 30 responders for 30 min according to the group, and then the patch of Comparative Example 3 or Examples 7 to 11 was removed by tooth brushing. Then, each group changed the products and then responded to a questionnaire for removal convenience.

(37) Criteria for Survey Response

(38) 5: Removal is very convenient and there is no residue in a toothbrush.

(39) 4: Removal is convenient but there is little residue in a toothbrush.

(40) 3: Removal is inconvenient and there is inconvenience due to residue in a toothbrush.

(41) 2: Removal is inconvenient and there are many residues in a toothbrush.

(42) 1: Removal is very inconvenient and there are so many residues in a toothbrush.

(43) As can be seen from FIG. 3, when the user brushed teeth at 30 min after attaching the patch of Comparative Example 3, it was evaluated that removal was generally inconvenient and there was many residues.

(44) However, the patches of Examples 7 to 11 mostly got 4 points or more, and most of them were evaluated that removal was convenient.

(45) It was confirmed that among them, the patches of Examples 9 to 11 used HPMC as a water-soluble polymer had especially excellent removability.

(46) <Evaluation of Degradation by Tooth Brushing>

(47) Two sets of Comparative Example 3 and Examples 7 to 11 were prepared. Each patch of one set was shaken in distilled water for 30 min to leave only a backing layer, dried and then weight of the patch was measured. Each patch of the other set was attached to a slide glass, stored in 37 C., 85% humidity environment for 30 min, and then brushed for 3 min using a brushing machine at a rate of 90 times per min back and forth at a load of 250 g. Then, the slide glass, the brushing chamber and the toothbrush were separated, and washed with distilled water while collecting the washing solution. The collected washing solution was filtered through a 500 m-mesh sieve, and residue was dried and weighed to calculate a ratio of the residue based on the total weight of the backing layer.

(48) TABLE-US-00007 TABLE 7 Comparative Exam. Exam. Exam. Exam. Exam. Exam. 3 7 8 9 10 11 Residue 97.9 15.6 15.9 3.7 3.3 3.8 ratio (wt %)

(49) As can be seen from Table 7, it was confirmed that the patch of Comparative Example 3 was hardly degraded by tooth brushing, and could not pass through the 500 m-mesh sieve. Namely, about 98 wt % or more of the patch was remained on the sieve.

(50) However, the patches of Examples 7 and 8 were remained about 15 wt % to 20 wt %, and most of the patches of Examples 9 to 11 were finely degraded to pass through the sieve, and about 5 wt % or less thereof was remained on the sieve.

(51) As can be seen from the above results, it can be found that among water-soluble polymers, especially HPMC, unlike other water-soluble polymers, allows the backing layer to be easily degraded by tooth brushing.

INDUSTRIAL APPLICABILITY

(52) The present invention can provide a patch which can be easily removed by tooth brushing after being attached to teeth or a surrounding part of teeth.

(53) The present invention has been described in detail. However, it should be understood that the detailed description and specific examples, while indicating preferred embodiments of the disclosure, are given by way of illustration only, since various changes and modifications within the scope of the disclosure will become apparent to those skilled in the art from this detailed description.