Meibomian gland probing with blood product injection

Abstract

A method of improving meibomian gland function in a patient includes inserting a cannula into an interior of a meibomian gland of the patient through an orifice thereinto, the cannula including at least one opening in communication with the interior of the meibomian gland, and injecting a blood product into the interior of the meibomian gland through the inserted cannula via the at least one opening.

Claims

1. A method of improving meibomian gland function in a patient, the method comprising: inserting a cannula into an interior of a meibomian gland of the patient through an orifice thereinto, the cannula including at least one opening in communication with the interior of the meibomian gland; and injecting a blood product into the interior of the meibomian gland through the inserted cannula via the at least one opening.

2. The method of claim 1, further comprising inserting at least one probe into the interior of the meibomian gland through the orifice prior to insertion of the cannula.

3. The method of claim 2, wherein inserting the at least one probe prior to insertion of the cannula includes inserting at least two probes of differing lengths prior to insertion of the cannula.

4. The method of claim 3, wherein inserting the at least two probes of differing lengths includes: first, inserting a 1-millimeter (mm) long probe; second, inserting a 2-mm long probe; and third, inserting a 4-mm long probe to a full length of the meibomian gland.

5. The method of claim 1, wherein injecting the blood product includes injecting autologous serum (AS).

6. The method of claim 5, wherein the AS is obtained using venipuncture.

7. The method of claim 5, wherein the AS is obtained using a finger prick.

8. The method of claim 5, wherein the AS is 50% AS.

9. The method of claim 1, wherein injecting the blood product includes injecting at least one of the following blood-derived sera: allogenic serum; umbilical cord serum; and recombinant serum.

10. The method of claim 1, wherein injecting the blood product includes injecting at least one of the following platelet preparations: platelet rich plasma; platelet lysate; platelet releasate; and platelet concentrate.

11. The method of claim 1, wherein injecting the blood product includes injecting fresh frozen plasma.

12. The method of claim 1, wherein injecting the blood product includes injecting at least one of albumin and fibronectin.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a side view of an eye and surrounding area of a patient prior to injection of blood products into one or more meibomian glands thereof; and

(2) FIG. 2 is a sectional view of one of the meibomian glands of FIG. 1 receiving an injection of blood products via a probe inserted through the orifice thereof, according to an embodiment of the present invention.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

(3) According to a preferred embodiment of the present invention, referring to FIGS. 1 and 2, meibomian gland 10 function is improved in a patient 12 via injection of one or more blood products, either alone or in combination with other substances. A probe 14 includes a cannula 16 having one of more openings 20 is inserted into one of the meibomian glands 10 through its orifice 22 located in an eyelid 24 of the patient 12.

(4) With the cannula 16 at least partially inserted, the openings 20 communicate with an interior 26 of the meibomian gland. The blood product is introduced into the cannula 16 as indicated by the arrow 30 and injected into the interior 26 of the meibomian gland 10 through the one or more openings 20 as indicated by the arrows 32. One or more preliminary probing steps can be performed before insertion of the cannula, typically with smaller probes. The process is repeated as necessary with the other meibomian glands. Multiple treatments of the same glands can also be performed over time.

(5) In one working example, treatment beings with the application of one drop of topical 0.5% tetracaine hydrochloride on the inferior fornix followed by placing a bandage contact lens over the eye. Topical anesthetic ointment consisting of 8% lidocaine with 25% jojoba in a petrolatum ointment base, is applied to the inferior lid margin. The eye is closed for 15 minutes. One additional drop of topical tetracaine is then placed in the eye. The patient is then positioned at the slit lamp. The meibomian gland orifices are then visualized and examined.

(6) A 1-mm long stainless steel sterile probe 16A is then inserted into each orifice, perpendicular to the lid margin using a dart throwing motion to find the angle of entry. Frequent pops and gritty sounds are heard by patient and physician as the periductal fibroses are released and the resistance gives way, allowing the probe to then freely pass to and fro within the duct. A 2-mm probe 16B will then be used, followed by a 4-mm probe 16C to extend the full length of the meibomian gland. After initial MGP, the cannula will be inserted into each gland in the lid being treated to deliver 50% AS. Alternately, fewer preliminary probing steps could be employed. Preferably, information on the meibomian glands are collected and logged during the probing.

(7) It is possible that MGP alone may not address a raw ductal epithelial defect. Healing of this defect may lead to subsequent minor narrowing of the duct diameter within months or years, with eventual redevelopment of pop/gritty sound with resistance upon re-probing. Hence, post-MGP use of intraductal AS is believed to promote rapid ductal re-epithelialization with restoration of ductal integrity, manifested not only by continued relief of symptoms, but also suppression or inhibition of pop/gritty sound resistance, which may promote or allow MG growth.

(8) Other biological substance, in addition to, or in place of, AS, might possibly be introduced with similar beneficial effects. For instance, blood-derived allogeneic, umbilical cord and recombinant sera could be used. Similarly, platelet preparations, such as platelet rich plasma, platelet lysate/releasate and platelet concentrate could be used. Albumin, fresh frozen plasma and fibronectin are additional options. Stem cells, whether derived from blood or non-hematologic tissue might reasonably be expected to achieve a similar effect, as well as amniotic-derived fluid or cells.

(9) The foregoing description of a preferred embodiment is provided for illustrative and exemplary purposes. The present invention is not necessarily limited thereto. Rather, those skilled in the art will appreciate that various modifications, as well as adaptations to particular circumstances, will fall within the scope of the invention as herein described and of the claims appended hereto.