IDENTIFICATION AND ISOLATION OF HUMAN CORNEAL ENDOTHELIAL CELLS (HCECS)

Abstract

The present invention provides methods for the identification, isolation and/or enrichment of human corneal endothelial cells (HCECs). In some embodiments, the method comprises a positive selection process in which a cell population containing human corneal cells is contacted with a positive affinity reagent that selectively binds to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.) in the population and/or a negative selection process in which a cell population containing HCECs is contacted with a negative affinity reagent that selectively binds to cells other than HCECs in the population relative to HCECs. The present invention also provides reagents and kits for the identification, isolation and/or enrichment of HCECs as well as compositions that are enriched in HCECs.

Claims

1. A method of forming a composition enriched with human corneal endothelial cells comprising: (a) contacting a cell population containing human corneal cells with a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) selecting cells to which the first positive affinity reagent is bound.

2. The method of claim 1, wherein the first positive affinity reagent selectively binds to human corneal endothelial cells relative to corneal keratocytes, human corneal endothelial cells of lower utility, or both.

3. The method of claim 1, wherein said first positive affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2.

4. The method of claim 1, wherein said first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.

5. The method of claim 1, wherein said first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).

6. The method of any of claims 1-5, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix.

7. The method of any of claims 1-6, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a label.

8. The method of claim 7, wherein the label is selected from a magnetic label, a hapten (e.g., biotin) and a fluorescent label.

9. The method of any of claims 1-8, further comprising (a) contacting said cell population containing human corneal cells with a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) selecting cells to which the second positive affinity reagent is bound, wherein the second positive affinity reagent differs from the first positive affinity reagent.

10. The method of claim 9, wherein said second positive affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2.

11. The method of claim 9, wherein said second positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.

12. The method of claim 9, wherein said second positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).

13. The method of any of claims 9-12, wherein the second positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.

14. The method of any of claims 1-13, further comprising (a) contacting said cell population containing human corneal cells with a first negative affinity reagent that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells and (b) removing the cells to which the first negative affinity reagent is bound.

15. The method of claim 14, wherein the first negative affinity reagent selectively binds to corneal keratocytes, human corneal endothelial cells of lower utility, or both, relative to human corneal endothelial cells.

16. The method of claim 14, wherein said first negative affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 of Table 2 and protein products of genes Z1 through Z8 of Table 2.

17. The method of claim 14, wherein said first negative affinity reagent comprises an antibody or aptamer that binds to a protein product of gene Y6 of Table 2.

18. The method of claim 14, wherein said first negative affinity reagent comprises an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68).

19. The method of any of claims 14-18, wherein the first negative affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.

20. A composition enriched with human corneal endothelial cells that is made by the method of any of claims 1-19.

21. A kit comprising (a) a positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells and (b) a negative affinity reagent that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells.

22. The kit of claim 21, wherein said positive affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2.

23. The kit of claim 21, wherein said first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.

24. The kit of claim 21, wherein said first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).

25. The kit of any of claims 21-24, wherein the positive affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.

26. The kit of any of claims 21-25, wherein said negative affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 and protein products of genes Z1 through Z8 of Table 2.

27. The kit of any of claims 21-25, wherein said negative affinity reagent comprises an antibody or aptamer that binds to a protein product of gene Y6 of Table 2.

28. The kit of any of claims 21-25, wherein said first negative affinity reagent comprises an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68).

29. The kit of any of claims 21-28, wherein the negative affinity reagent comprises an antibody or aptamer that is coupled to a solid matrix or a label.

30. An affinity reagent selected from (a) a solid matrix or a label coupled to an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2 and (b) a solid matrix or a label coupled to an antibody or aptamer that binds to a corneal protein selected from protein products of genes Y1 through Y23 and protein products of genes Z1 through Z8 of Table 2.

31. A composition enriched with human corneal endothelial cells comprising: (a) human corneal cells and (b) a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells.

32. The composition of claim 31, comprising human corneal endothelial cells to which the first positive affinity reagent is bound.

33. The composition of any of claims 31-32, wherein the first positive affinity reagent selectively binds to human corneal endothelial cells relative to corneal keratocytes, human corneal endothelial cells of lower utility, or both.

34. The composition of any of claims 31-33, wherein said first positive affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2.

35. The composition of any of claims 31-33, wherein said first positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.

36. The composition of any of claims 31-33, wherein said first positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).

37. The composition of any of claims 31-36, wherein the first positive affinity reagent comprises an antibody or aptamer that is coupled to a label.

38. The composition of claim 37, wherein the label is selected from a magnetic label, a hapten (e.g., biotin) and a fluorescent label.

39. The composition of any of claims 31-38, further comprising a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to cells other than human corneal endothelial cells, wherein the second positive affinity reagent differs from the first positive affinity reagent.

40. The composition of claim 39, comprising human corneal endothelial cells to which the second positive affinity reagent is bound.

41. The composition of any of claims 39-40, wherein said second positive affinity reagent comprises an antibody or aptamer that binds to a corneal protein selected from protein products of genes X1 through X26 of Table 2.

42. The composition of any of claims 39-40, wherein said second positive affinity reagent comprises an antibody or aptamer that binds to a protein product of gene X5 of Table 2, an antibody or aptamer that binds to a protein product of gene X15 of Table 2, or an antibody or aptamer that binds to a protein product of X25 of Table 2.

43. The composition of any of claims 39-40, wherein said second positive affinity reagent comprises (a) an antibody or aptamer that binds to SEQ ID NO (8), (b) an antibody or aptamer that binds to one or more of SEQ ID NO (27), SEQ ID NO (28), SEQ ID NO (29), SEQ ID NO (30) or SEQ ID NO (31), or (c) an antibody or aptamer that binds to one or more of SEQ ID NO (53), SEQ ID NO (54), SEQ ID NO (55), SEQ ID NO (56) or SEQ ID NO (57).

44. The composition of any of claims 39-43, wherein the second positive affinity reagent comprises a label.

45. The composition of any of claims 31-44, comprising a measurable amount of one or more negative affinity reagents that selectively binds to cells other than human corneal endothelial cells relative to human corneal endothelial cells.

46. The composition of claim 45, wherein the one or more negative affinity reagents selectively binds to corneal keratocytes, human corneal endothelial cells of lower utility, or both, relative to human corneal endothelial cells.

47. The composition of any of claim 45-46, wherein said one or more negative affinity reagents comprise one or more antibodies that bind to one or more corneal proteins selected from protein products of genes Y1 through Y23 of Table 2 and protein products of genes Z1 through Z8 of Table 2.

48. The composition of any of claims 45-46, wherein said one or more negative affinity reagents comprise an antibody or aptamer that binds to a protein product of gene Y6 of Table 2.

49. The composition of any of claims 45-46, wherein said one or more negative affinity reagents comprise an antibody or aptamer that binds to one or more of SEQ ID NO (66), SEQ ID NO (67) or SEQ ID NO (68).

50. The composition of any of claims 45-49, wherein the one or more negative affinity reagents comprise an antibody or aptamer that is coupled to a label.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0066] FIGS. 1A-1C are bright field micrographs of HCECs and keratocytes in culture, with FIG. 1A illustrating a HCEC culture having preserved a typical cobblestone morphology (P2-HCEC-Good), FIG. 1B illustrating a HCEC culture having become fibroblastic (P3-HCEC-Fibroblastic), and FIG. 1C illustrating a human corneal keratocyte culture (P2-HCEC-Keratocytes).

[0067] FIG. 2 illustrates in bar graph form expression of four surface markers in different corneal cell populations analyzed by flow cytometry.

[0068] FIGS. 3A-3C are dual-color fluorescence histograms of HCECs and keratocytes. These dot plots show the differential expression of two surface markers (CD56:CD166, CD56:CD90 and CD56:CAR) in each cell population, with FIG. 3A corresponding to the P2-HCEC-Good culture shown in FIG. 1A, FIG. 3B corresponding to the P3-HCEC-Fibroblastic culture shown in FIG. 1B, and FIG. 3C corresponding to the P2-HCEC-Keratocytes culture shown in FIG. 1C.

[0069] FIGS. 4A-4D present Fluorescence profiles illustrating expression of four surface markers, specifically, CD56 (FIG. 4A), CAR (FIG. 4B), CD109 (FIG. 4C) and CD248 (FIG. 4D) in three different HCEC populations, specifically, canonical (good) HCECs, mixed (canonical and fibroblastic) HCECs, and fibroblastic (HCECs), analyzed by flow cytometry.

[0070] FIG. 5 illustrates in bar graph form expression of four surface markers in three different HCEC populations analyzed by flow cytometry.

[0071] FIGS. 6A-6C illustrates dual-color fluorescence histograms for various pairs of surface markers, specifically, CD56:CD248 (FIG. 6A), CD56:CD109 (FIG. 6B) and CD56:CAR (FIG. 6C) in three different HCEC populations, specifically, canonical HCECs, mixed HCECs and fibroblastic HCECs.

[0072] FIG. 7 illustrates trans-endothelial electrical resistance (TEER) as a function of time for cell cultures of three different HCEC populations.

DETAILED DESCRIPTION

[0073] A more complete understanding of the present invention is available by reference to the following detailed description of numerous aspects and embodiments of the invention. The detailed description of the invention which follows is intended to illustrate but not limit the invention.

[0074] As noted above, in some aspects, the present disclosure pertains to positive selection processes in which cell populations containing human corneal cells are contacted with one or more positive affinity reagents that selectively bind to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.), including positive affinity reagents that selectively bind to HCECs that are likely to have a higher clinical efficacy relative to the general HCEC population

[0075] In other aspects, the present disclosure pertains to negative selection processes in which cell populations containing human corneal cells are contacted with one or more negative affinity reagents that bind selectively bind to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs.

[0076] These negative and positive selection methods may be used independently or in combination with one another, for example, to identifying HCECs, to isolate HCECs and/or to enrich cell populations with HCECs, among other uses.

[0077] Cell populations suitable for HCEC enrichment or isolation include those obtained from intact or residual human corneas, which may come, for instance, from embryonic, fetal, pediatric or adult tissue. For example, intact corneas may be subjected to a peel-off step in which the endothelium and its basement membrane (Descemet's membrane) are peeled off the stroma and collected. See Ko-Hua Chen et al., Transplantation of Adult Human Corneal Endothelium Ex Vivo: A Morphologic Study, Cornea 20(7): 731-737, 2001. In other embodiments, cell populations may be obtained from residual corneas (e.g., eye tissue remaining after a corneal button has been used for DSAEK).

[0078] Tissue from intact and residual corneas may be separated into individual cells by processes such as enzymatic and/or mechanical dissociation. At this step, cells are incubated for a period of time at room temperature or at 37 C. with a single enzyme or a combination of enzymes including some of the following: collagenase, papain, dispase, elastase, trypsin/EDTA, and/or DNAse. Later the tissues are mechanically dissociated using a conventional pipette or a glass pipette to obtain individual cells or cell clumps than can be then expanded in culture. See, e.g., Li W. et al., Invest Ophthalmol Vis Sci 2007; 48: 614; Ishino Y. et al., Invest Ophthalmol Vis Sci 2004; 45: 800; Chen K. H. et al., Cornea 2001; 20: 731.

[0079] The medium in which the cells may be suspended will be any medium which maintains the viability of HCECs. Various media are commercially available and may be used including Minimal Essential Medium (MEM), Dulbecco's Modified Eagle Medium (DMEM), Opti-MEMO, Media 199 or M199, Dulbecco's Modified Eagle Medium with Nutrient Mixture F-12 (DMEM/F-12), F99 Ham's F12, SHEM Ham's F12, EGM-2 endothelial growth medium frequently supplemented with serum of human or animal origin, BSA, HSA, growth factors, antioxidants, antibiotics, antimicotic agents, hormones, amino acids, and peptides. Specific examples of media are shown in Table 1 to follow.

TABLE-US-00001 TABLE 1 Base Medium Serum Growth Factors & Supplements [M1] 10% 2 ng/ml bFGF DMEM 50 U/ml penicillin 50 g/ml streptomycin [M2] 8% 20 ng/ml NGF Opti-MEM-I 5 ng/ml EGF 20 g/ml ascorbic acid 200 mg/L calcium chloride 100 g/ml pituitary extract 50 g/ml gentamicin 1x antibiotic/antimycotic 0.08% chondroitin sulphate [M3] 5% 0.5% DMSO SHEM 2 ng/ml EGF Ham's F12 & DMEM 5 g/ml insulin (1:1 ratio) 5 g/ml transferrin 5 ng/ml selenium 0.5 g/ml hydrocortisone 1 nM cholera toxin 50 g/ml gentamicin 1.25 g/ml amphotericin B [M4] 5% 20 g/ml ascorbic acid F99 20 g/ml bovine insulin Ham's F 12 & M100 2.5 g/mol transferrin (1:1 ratio) 0.6 ng/ml sodium selentite 10 ng/ml bFGF

[0080] Cell cultures from intact and residual corneas contain unwanted contaminant cells which arise from residual non-endothelial tissue (e.g., stroma, epithelium, etc.) that may be present in the sample. In a culture of HCECs, HCECs that are of low cell transplant utility compared to other HCECs of high cell transplant utility may also be considered, in some fashion, contaminants.

[0081] Cell populations suitable for HCEC enrichment or isolation also include HCEC cultures in which contaminant cells have out-multiplied HCECs or in which HCECs have transformed spontaneously into other types of cells (e.g., keratocytes, etc.). As previously noted, contaminant cells such as keratocytes are particularly undesirable where it is desired to expand an HCEC culture ex vivo, because such cells grow faster than HCECs and can thus take over a cell culture.

[0082] Consequently, various aspects of the invention pertain to methods, reagents and kits for separation of HCECs from other cells, particularly, keratocytes and/or HCECs of lower utility. The HCECs are separated from mixtures of cells by techniques that select cells having particular characteristics.

[0083] Human corneal endothelial cells may identified or selected (a) through positive cell markers, which are cell markers that are found on the surfaces of HCECs but which are not found on the surfaces of contaminant cells which may be intermixed with HCECs (e.g., positive selection), (b) through negative cell markers, which are cell markers that are found on surfaces of contaminant cells that are intermixed with HCECs and but which are not found on the surfaces of HCECs (e.g., negative selection), and through a combination of positive and negative cell markers.

[0084] For example, in the case where whole human corneas are used as a source of endothelial cells, positive cell markers may be selected from corneal proteins which are found in the endothelium (which is formed from HCECs) but which are not found in other corneal tissue (i.e., the stroma and/or the epithelium). Conversely, negative cell markers may be selected from corneal proteins which are found in corneal tissue other than endothelium tissue (i.e., the stroma and/or the epithelium) but which are not found in corneal endothelium.

[0085] As another example, in the case where the source of endothelial cells is an endothelium and basement membrane that have been separated from the stroma and epithelium of an intact cornea, positive cell markers may be selected from corneal cell proteins which are found in the endothelium but which are not found in the stroma, while negative cell markers may be selected from corneal cell proteins which are found in the stroma but which are not found in corneal endothelium.

[0086] Corneal proteins which may be useful as cell markers in conjunction with the present invention include the suitable proteins selected from those presented in the Table 2 set forth in Appendix A.

[0087] Positive cell markers include suitable corneal proteins selected from protein products of genes X1-X26 in Table 2 (e.g., SEQ ID NO (1) through SEQ ID NO (58)) which are present in the corneal endothelium but are not present in the stroma or the epithelium.

[0088] Negative cell markers include (a) suitable corneal proteins selected from protein products of genes Y1-Y23 in Table 2 (e.g., SEQ ID NO (59) through SEQ ID NO (96)), which are present in the stroma and in epithelium but are not present in the endothelium and (b) suitable corneal proteins selected from protein products of genes Z1-Z8 in Table 2 (e.g., SEQ ID NO (97) through SEQ ID NO (109)), which are present in the stroma but are not present in the corneal endothelium (or epithelium).

[0089] As previously noted, in some aspects, the present disclosure pertains to (a) positive selection processes in which cell populations containing human corneal cells are contacted with one, two, three, four or more positive affinity reagents that selectively bind to HCECs relative to cells other than HCECs (e.g., corneal keratocytes, etc.), (b) negative selection processes in which cell populations containing human corneal cells are contacted with one, two, three, four or more negative affinity reagents that selectively bind to cells other than HCECs (e.g., corneal keratocytes, etc.) relative to HCECs, and (c) combinations of (a) and (b).

[0090] For this purpose, affinity reagents are employed which preferentially bind to various corneal proteins. Positive affinity reagents are those that preferentially bind to positive cell markers associated with HCECs while negative affinity reagents are those that preferably bind to negative cell markers associated with contaminant cells other than HCECs.

[0091] Various positive cell markers are described above and include corneal proteins which are found in the endothelium (which is formed from HCECs) but which are not found in other corneal tissue (i.e., the stroma and/or the epithelium). Various negative cell markers are also described above and include corneal proteins which are found in corneal tissue other than endothelium (i.e., the stroma and/or the epithelium) but which are not found in corneal endothelium.

[0092] Those skilled in the art will recognize that suitable negative and positive affinity reagents can be employed in any order and/or in any combination.

[0093] Affinity reagents suitable for use in the present disclosure may comprise any species which selectively binds to a given surface marker, including positive affinity reagents which selectively bind to positive cell markers and negative affinity reagents which selectively bind to negative cell markers.

[0094] Especially useful affinity reagents for the practice of the invention are antibodies (also referred to herein as affinity antibodies), nucleic acid aptamers and other engineered forms of protein scaffolds. Antibodies include whole antibodies and antibody fragments, e.g. Fab, F(ab)2, light or heavy chain fragments, etc.

[0095] Affinity antibodies selected for use will have a low level of non-specific interactions.

[0096] Affinity antibodies may be polyclonal or monoclonal and, where not commercially available, may be readily produced by techniques known to those skilled in the art.

[0097] For instance, affinity antibodies to a given corneal protein may be obtained by immunizing a xenogeneic immunocompetent mammalian host (including murine, rodentia, lagomorpha, ovine, porcine, bovine, etc.) with the corneal protein of interest. Immunizations are performed in accordance with conventional techniques, where the corneal proteins may be injected subcutaneously, intramuscularly, intraperitoneally, intravascularly, etc., over a course of one or more injections. After completion of the immunization schedule, the antiserum may be harvested in accordance with conventional methods to provide polygonal antisera specific for the corneal protein of interest. Lymphocytes may also be harvested from the appropriate lymphoid tissue, e.g. spleen, draining lymph node, etc., and fused with an appropriate fusion partner, for example, a myeloma line, producing a hybridoma secreting a specific monoclonal antibody. Screening clones of hybridomas for the antigenic specificity of interest is performed in accordance with conventional methods.

[0098] In numerous embodiments, affinity antibodies are coupled to a suitable substrate, for example, a label or a solid matrix. Labels include magnetic labels such as magnetic beads or micro or nanoparticles including superparamagnetic nanoparticles, which allow for ease of separation. Labels also include biotin, which binds with high affinity to avidin or streptavidin. Labels further include fluorochromes, which can be used with flow cytometry, e.g., fluorescence activated cell sorting (FACS), or the like, to allow for ease of separation of a particular cell type. Fluorescence activated cell sorters have varying degrees of sophistication, such as multiple color channels, low angle and obtuse light scattering detecting channels, impedance channels, etc. Fluorochromes include phycobiliproteins, e.g., phycoerythrin and allophycocyanins, fluorescein and Texas red, cy7 and cy5, among others. Multiple antibodies each with an affinity to a particular corneal protein may each be labeled with a different fluorochrome, to permit independent sorting (multi-color analyses) for each associated cell protein.

[0099] Cell selection may also be achieved by panning with an affinity antibody attached to a solid matrix, e.g. a plate, an immobilized bead, and so forth. For example, an affinity antibody that has specificity for a particular corneal protein may be bound to a solid matrix and corneal cells displaying that particular corneal protein can be captured by the immobilized antibody while the other cells remain in suspension and can be removed.

[0100] Any sorting technique may be employed which is not unduly detrimental to the viability of the selected cells. Combinations of the above techniques may be used.

[0101] The precise method for coupling an antibody to a given substrate (e.g., a label, solid matrix, etc.) is not critical to the practice of the present disclosure, and a number of alternatives are known in the art. For example, affinity antibodies may directly or indirectly be coupled to a substrate. Direct coupling to a substrate can be achieved by use of various chemical linking groups, as known in the art. For example, an antibody can be coupled to a substrate through side chain amino or sulfhydryl groups and heterofunctional cross-linking reagents. Many heterofunctional compounds are available for linking to various entities. Specific examples include 3-(2-pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) or 4-(N-maleimidomethyl)-cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester (SMCC), which can react with a reactive sulfhydryl group on the antibody and a reactive amino group on the substrate.

[0102] Alternatively, affinity antibodies can be indirectly coupled to a substrate via a hapten or a secondary antibody. For instance, the antibody may be directly conjugated to a hapten, and hapten-specific binding species may be conjugated to the substrate. Suitable haptens include digoxin, digoxigenin, FITC, dinitrophenyl, nitrophenyl, avidin, streptavidin, biotin, etc. For example, an antibody may be coupled to one member of a high affinity binding system (e.g., biotin) and another member of the high affinity binding system (e.g., avidin) attached to a substrate. Methods for conjugation of a hapten to a protein are known in the art, and kits for such conjugations are commercially available. The secondary antibody may be directly or indirectly bound to the substrate.

[0103] During cell separation, coupled antibodies may be combined with a suspension of cells and incubated for a period of time sufficient for the antibodies to bind to proteins on the cells. The amount of antibody necessary to bind a particular cell subset may be empirically determined by performing a test separation and analysis. The cells and antibodies are incubated for a period of time sufficient for binding to occur.

[0104] The medium in which the cells are separated will be any medium which maintains the viability of the cells. Various media are commercially available and include those listed above.

[0105] Coupled affinity antibodies include coupled positive affinity antibodies specific for the corneal proteins which are present on human corneal endothelial cells and which are not present on contaminant cells such as stromal and/or epithelial cells (for positive selection) and coupled negative affinity antibodies specific for corneal proteins which are present on contaminant cells such as stromal and/or epithelial cells and which are not present on human corneal endothelial cells (negative selection).

[0106] Once the antibody is bound to the cell, the bound cells are separated in accordance with the specific antibody preparation. For example, FACS separation may be used with fluorochrome labeled antibodies, immunomagnetic selection may be used with magnetic-labeled antibodies, panning may be employed with immobilized antibodies, and so forth.

[0107] Cells may be separated from affinity antibodies using known techniques, as desired. As a specific example, where an antibody in an immunopanning process is a positive selection antibody, the matrix with attached endothelial cells may be washed to remove unbound cells and the endothelial cells released using a suitable technique (e.g., trypsin digest).

[0108] While various specific embodiments employing antibodies as affinity reagents are specifically described herein, it is to be understood that other affinity reagents for binding positive or negative cell markers can be used in the same fashion, including nucleic acid aptamers and other engineered forms of protein scaffolds. Aptamers are synthetic oligonucleotides selected from pools of random-sequence oligonucleotides which bind to a wide range of biomolecular targets with high affinity and specificity. See, e.g., J. Wang and G. Li, Aptamers against cell surface receptors: selection, modification and application, Curr Med Chem. 2011; 18(27):4107-16.

[0109] The separated cells may be collected in any appropriate medium that maintains the viability of the cells.

[0110] Cell populations enriched with HCECs may thus be achieved in this manner. The HCEC population may constitute 50% or more of the cells in the cell composition, preferably at 75% or more of the cells in the cell composition, more preferably at 90% or more of the cells in the cell composition, and may be as many as 95% or more (e.g. substantially pure) of the cells in the cell population. Conversely, the cell populations may contain up to 50% of cells other than HCECs (e.g., corneal keratocytes, etc.), for instance 50% or less of such cells, preferably 25% or less of such cells, more preferably 10% or less of such cells, and may be as few as 5% or less of such cells.

[0111] The enriched cell population may be used immediately or stored. For example, at room temperature, at 4 C., at 37 C. or the cells may be frozen at liquid nitrogen temperatures and stored for long periods of time.

[0112] In certain embodiments, the enriched cells may be further expanded in vitro by adding culture media as described widely in the literature. See, e.g., Li W et al., Invest Ophthalmol Vis Sci 2007; 48: 614.; Ishino Y et al., Invest Ophthalmol Vis Sci 2004; 45: 800; Chen K H et al., Cornea 2001; 20: 731.

[0113] The enriched HCEC compositions thus obtained have a variety of uses in clinical therapy, research, development, and commercial purposes.

[0114] For example, for therapeutic purposes, human corneal endothelial cells may be ocularly administered to an eye of a patient in order to treat corneal endothelial cell loss or dysfunction.

[0115] Other aspects of the invention pertain to kits for conducting cell separations as described herein. Such kits may include any combination of the following, among other elements: (a) one, two, three or more positive affinity reagents, each of which may be, for example, in the form of a positive affinity antibody attached to a suitable substrate such as a solid matrix (e.g. a plate, immobilized bead, etc.) or label (e.g., magnetic label, fluorescent label, etc.), (b) one, two, three or more unlabeled positive affinity antibodies, which the end user could label using standard methods, choosing their preferred labels (e.g., fluorophores, haptens, etc.), (c) one, two, three or more negative affinity reagents, each of which may be, for example, in the form of a negative affinity antibody attached to a suitable substrate such as a solid matrix (e.g. a plate, immobilized bead, etc.) or label (e.g., magnetic label, fluorescent label, etc.), (d) or one, two, three or more unlabeled negative affinity antibodies, which the end user could label using standard methods, choosing their preferred labels (e.g., fluorophores, haptens, etc.); (e) a combination of (a) and (c); (f) a combination of (b) and (d); (g) packaging; (h) printed materials with one or more of the following: (i) storage information and (ii) instructions regarding how to use the materials contained in the kit (e.g., positive affinity reagents, negative affinity reagents, a combination of antibodies for sequential use, etc.).

Example 1

[0116] HCECs were isolated from cadaveric donor corneas (Tampa Lions Eye Bank) and cultured and expanded following the method described by Joyce and Zhu in Cornea. 2004 November; 23(8 Suppl):S8-S19. Briefly, the endothelium and Descemet's membrane were peeled off of the stroma and after overnight stabilization at 37 C. in Opti-MEMO media (Gibco, Life Technologies Corp, Carlsbad, CA), supplemented with 8% fetal bovine serum (FBS), they were incubated for 1 hr at 37 C. with ethylenediaminetetraacetic acid (EDTA) to loosen up the cell-cell interactions. Cells were then mechanically dissociated to obtain a single-cell suspension, they were seeded onto FNC-coated culture wells and labeled as P0 (passage zero). After reaching confluency, they were trypsinized and further expanded into more wells to increase their number. After one or two rounds of expansion, cells were collected and incubated with different antibodies as indicated below. Keratocytes were also obtained from cadaveric donor corneas using the method described by Stramer et al. in Monoclonal antibody (3G5)-defined ganglioside: cell surface marker of corneal keratocytes, Invest. Ophthalmol. Vis. Sci. 2004 vol. 45 no. 3 807-812. While one of the HCEC cultures preserved its typical cobblestone morphology at passage 2 (FIG. 1A), a second culture underwent endothelial-to-mesenchymal transition during passage 3 (P3) and the cells became fibroblastic (FIG. 1B). Such cells are generally referred to herein as human corneal endothelial cells of lower utility (e.g., HCECs that have undergone fibroblastic or mesenchymal transformation, etc.) The keratocyte culture exhibits the typical fibroblastic, elongated cell morphology (FIG. 1C).

[0117] HCECs from each culture and keratocytes were collected and incubated with one or more of the following labelled antibodies: (a) APC-CD56 which is a mouse monoclonal antibody against a protein product of gene X15 from Table 2 (referred herein to as CD56 surface protein) coupled to allophycocyanin (BD Biosciences, #555518), (b) PE-CD166, which is a mouse monoclonal antibody against a protein product of gene X1 from Table 2 (referred here to as CD166 surface protein) coupled to phycoerythin (BD Biosciences #559263), (c) FITC-CAR, which is a mouse monoclonal antibody against a protein product of gene X25 from Table 2 (referred to as CAR surface protein) coupled to fluorescein-5-Isothiocyanate (Santa Cruz Biotechnology, Santa Cruz, California, USA #sc-56892) and (d) PECy7-CD90, which is a mouse monoclonal antibody against a protein product of gene Z8 from Table 2 (referred to as CD90 surface protein) coupled to a tandem conjugate of PE (energy donor) which has an excitation wavelength of 565 nm and Cy7 (energy acceptor) which has an emission wavelength of 778 nm) (BD Biosciences #561558).

[0118] Expression of surface markers was analyzed using a BD LSR II flow cytometry system (BD Biosciences, San Jose, CA). The data shown in FIG. 2 are representative from one experiment. Similar results were obtained upon repeated experimentation. Quantification of the % positive cells for each marker shows that in fibroblastic cultures there is a decreased expression of CD56 and CAR, indicating that antibodies to these proteins may be used in conjunction with positive affinity reagents for good HCECs. A significant difference in the expression of CD166 or CD90 was not detected using this particular antibody.

[0119] FIGS. 3A-3C are dual-color fluorescence dot plots of the HCECs and keratocytes. These dot plots show the differential expression of two surface markers in each cell population as labeled. The percent of cells positive for an individual marker is shown in FIG. 2.

Example 2

[0120] HCECs were isolated from cadaveric donor corneas as described in Example 1. Also as discussed in Example 1, HCEC cultures were obtained (a) which evidenced a typical cobblestone morphology (referred to in this Example 2 as a canonical cell culture), (b) where all the cells had undergone an endothelial-to-mesenchymal transition (referred to in this Example as a fibroblastic cell culture) and (c) where some HCECs had undergone endothelial-to-mesenchymal transition (referred to in this Example as a mixed cell culture).

[0121] HCEC surface markers were identified by microarray data, and several with high expression in the endothelium (cultured and freshly dissected) but low expression in stroma were selected to be tested by flow cytometry analysis. In addition to APC-CD56, PE-CD166, FITC-CAR and PECy7-CD90 described in Example 1, also tested were (e) CD109-PE, (i.e., mouse anti-CD109), which is a monoclonal antibody against a protein product of gene Y6 from Table 2 (referred to as CD109 antigen) conjugated to phycoerythrin (PE), BD Biosciences Cat #556040 and (f) CD 248-BV, (i.e., mouse anti-Endosialin), which is an unconjugated monoclonal antibody against a protein product of gene X5 from Table 2 (referred to as CD248 antigen or Endosialin), (Millipore, Temecula, CA, USA, Cat #MAB2626), incubated with Goat polyclonal anti-Mouse IgG secondary antibody conjugated to Brilliant Violent 421 (Biolegend, Inc., San Diego, CA, USA, Cat #405317).

[0122] To address whether the expression of those markers in HCECs were affected by the fibroblastic conversion described above, HCEC cultures demonstrating two different morphologies (canonical and fibroblastic) and a corneal keratocyte culture as a control were immunostained for the surface proteins CD90, CAR, CD56 and CD166 (See Example 1, FIG. 2). CD56, CAR, CD109 and CD248 expression was also compared between canonical (good), mixed, and fibroblastic HCECs (see FIGS. 4A-4D and 5). Analysis of the percentage of cells expressing any of the individual markers in canonical and fibroblastic cultures demonstrated that CD56, CAR and CD248 expression was reduced in the fibroblastic culture (see FIG. 5), while CD109 was elevated (see FIG. 5); CD90 and CD166 expression did not significantly change between good/canonical and fibroblastic cultures (see Example 1, FIG. 2). A comparable trend was observed in the keratocyte culture used as control for CD90, CAR, CD56 and CD166 expression (see Example 1, FIG. 2).

[0123] Dot plot dual histograms of canonical, mixed and fibroblastic cultures shown in FIGS. 6A-6C demonstrated that canonical HCECs are predominantly CD56, CD248 and CAR positive, and CD109 negative; CD56 and CD248 expression is lost and CD109 expression increases as the culture becomes fibroblastic.

[0124] Finally, trans-endothelial electrical resistance (TEER) of cell cultures was measured. HCECs (a) from good or canonical cultures that expressed high levels of CD56, (b) from mixed cultures and (c) from fibroblastic cultures were plated onto inserts with 0.4 mm pores in 24-well culture plates (Transwell, Corning Costar, Acton, MA) at a density of 20,000 cells/insert and incubated in growth media as described in Example 1. TEER was measured using an EVOM volt-ohm meter with STX2 Electrode (World Precision Instrument, Inc., Sarasota, FL) for up to 65 days after initial plating. TEER measures the apical and basal plasma membrane resistance and the paracellular resistance and is used as an index of monolayer confluence integrity of tight junctions. To calculate final resistance (.Math.cm2), the resistance of blank filters were subtracted from those of filters with cells. Four wells per condition were averaged. HCECs exhibiting a canonical morphology and being CD56-positive demonstrated a superior barrier formation ability measured by TEER (FIG. 7).

[0125] Thus, we have identified a panel of surface makers that can be used to characterize a canonical and functionally superior HCEC culture, and may be used as quality control criteria or to potentially separate the best HCEC subpopulations for expansion.

[0126] Although various embodiments are specifically illustrated and described herein, it will be appreciated that modifications and variations of the present invention are covered by the above teachings and are within the purview of any appended claims without departing from the spirit and intended scope of the invention.

APPENDIX A

[0127]

TABLE-US-00002 TABLE2 GeneID: X1 Genesymbol: ALCAM Genedescription: activatedleukocytecelladhesionmolecule Unigene: Hs.591293 Genbank: DQ486139 EntrezGene: 214 Refseq: NM_001627 Proteinsequence(SEQIDNO(1)): 1 meskgasscrllfcllisatvfrpglgwytvnsaygdtiiipcrldvpqnlmfgkwkyek 61 pdgspvfiafrsstkksvqyddvpeykdrlnlsenytlsisnarisdekrfvcmlvtedn 121 vfeaptivkvfkqpskpeivskalfleteqlkklgdcisedsypdgnitwyrngkvlhpl 181 egavviifkkemdpvtqlytmtstleykttkadiqmpftcsvtyygpsgqktihseqavf 241 diyypteqvtiqvlppknaikegdnitlkclgngnpppeeflfylpgqpegirssntytl 301 tdvrrnatgdykcslidkksmiastaitvhyldlslnpsgevtrqigdalpvsctisasr 361 natvvwmkdnirlrsspsfsslhyqdagnyvcetalqeveglkkresltlivegkpqikm 421 tkktdpsglsktiichvegfpkpaiqwtitgsgsvinqteespyingryyskiiispeen 481 vtltctaenqlertvnslnvsaisipehdeadeisdenrekvndqaklivgivvglllaa 541 lvagvvywlymkksktaskhvnkdlgnmeenkkleennhktea GeneID: X2 Genesymbol: ATP1A1 Genedescription: sodium/potassium-transportingATPasesubunitalpha-1 Unigene: Hs.371889 Genbank: BC003077 EntrezGene: 476 Refseq: NM_000701|NM_001160233|NM_001160234 Proteinsequenceisoforma(SEQIDNO(2)): 1 mgkgvgrdkyepaavseqgdkkgkkgkkdrdmdelkkevsmddhklsldelhrkygtdls 61 rgltsaraaeilardgpnaltpppttpewikfcrqlfggfsmllwigailcflaysiqaa 121 teeepqndnlylgvvlsavviitgcfsyyqeaksskimesfknmvpqqalvirngekmsi 181 naeevvvgdlvevkggdripadlriisangckvdnssltgesepqtrspdftnenpletr 241 niaffstncvegtargivvytgdrtvmgriatlasgleggqtpiaaeiehfihiitgvav 301 flgvsffilslileytwleavifligiivanvpegllatvtvcltltakrmarknclvkn 361 leavetlgststicsdktgtltqnrmtvahmwfdnqiheadttenqsgvsfdktsatwla 421 lsriaglcnravfqanqenlpilkravagdasesallkcielccgsvkemreryakivei 481 pfnstnkyqlsihknpntsepqhllvmkgaperildressillhgkeqpldeelkdafqn 541 aylelgglgervlgfchlflpdeqfpegfqfdtddvnfpidnlcfvglismidppraavp 601 davgkcrsagikvimvtgdhpitakaiakgvgiisegnetvediaarlnipvsqvnprda 661 kacvvhgsdlkdmtseqlddilkyhteivfartspqqkliivegcqrqgaivavtgdgvn 721 dspalkkadigvamgiagsdvskqaadmillddnfasivtgveegrlifdnlkksiaytl 781 tsnipeitpflifiianiplplgtvtilcidlgtdmvpaislayeqaesdimkrqprnpk 841 tdklvnerlismaygqigmiqalggfftyfvilaengflpihllglrvdwddrwindved 901 sygqqwtyeqrkiveftchtaffvsivvvqwadlvicktrrnsvfqqgmknkilifglfe 961 etalaaflsycpgmgvalrmyplkptwwfcafpysllifvydevrkliirrrpggwveke 1021 tyy Proteinsequenceisoformc(SEQIDNO(3)): 1 mafkvgrdkyepaavseqgdkkgkkgkkdrdmdelkkevsmddhklsldelhrkygtdls 61 rgltsaraaeilardgpnaltpppttpewikfcrqlfggfsmllwigailcflaysiqaa 121 teeepqndnlylgvvlsavviitgcfsyyqeaksskimesfknmvpqqalvirngekmsi 181 naeevvvgdlvevkggdripadlriisangckvdnssltgesepqtrspdftnenpletr 241 niaffstncvegtargivvytgdrtvmgriatlasgleggqtpiaaeiehfihiitgvav 301 flgvsffilslileytwleavifligiivanvpegllatvtvcltltakrmarknclvkn 361 leavetlgststicsdktgtltqnrmtvahmwfdnqiheadttenqsgvsfdktsatwla 421 lsriaglcnravfqanqenlpilkravagdasesallkcielccgsvkemreryakivei 481 pfnstnkyqlsihknpntsepqhllvmkgaperildressillhgkeqpldeelkdafqn 541 aylelgglgervlgfchiflpdeqfpegfqfdtddvnfpidnlcfvglismidppraavp 601 davgkcrsagikvimvtgdhpitakaiakgvgiisegnetvediaarlnipvsqvnprda 661 kacvvhgsdlkdmtseqlddilkyhteivfartspqqkliivegcqrqgaivavtgdgvn 721 dspalkkadigvamgiagsdvskqaadmillddnfasivtgveegrlifdnlkksiaytl 781 tsnipeitpflifiianiplplgtvtilcidlgtdmvpaislayeqaesdimkrqprnpk 841 tdklvnerlismaygqigmiqalggfftyfvilaengflpihllglrvdwddrwindved 901 sygqqwtyeqrkiveftchtaffvsivvvqwadlvicktrrnsvfqqgmknkilifglfe 961 etalaaflsycpgmgvalrmyplkptwwfcafpysllifvydevrkliirrrpggwveke 1021 tyy Proteinsequenceisoformd(SEQIDNO(4)): 1 mdelkkevsmddhklsldelhrkygtdlsrgltsaraaeilardgpnaltpppttpewik 61 fcrqlfggfsmllwigailcflaysiqaateeepqndnlylgvvlsavviitgcfsyyqe 121 aksskimesfknmvpqqalvirngekmsinaeevvvgdlvevkggdripadlriisangc 181 kvdnssltgesepqtrspdftnenpletrniaffstncvegtargivvytgdrtvmgria 241 tlasgleggqtpiaaeiehfihiitgvavflgvsffilslileytwleavifligiivan 301 vpegllatvtvcltltakrmarknclvknleavetlgststicsdktgtltqnrmtvahm 361 wfdnqiheadttenqsgvsfdktsatwlalsriaglcnravfqanqenlpilkravagda 421 sesallkcielccgsvkemreryakiveipfnstnkyqlsihknpntsepqhllvmkgap 481 erildrcssillhgkeqpldeelkdafqnaylelgglgervlgfchlflpdeqfpegfqf 541 dtddvnfpidnlcfvglismidppraavpdavgkcrsagikvimvtgdhpitakaiakgv 601 giisegnetvediaarlnipvsqvnprdakacvvhgsdlkdmtseqlddilkyhteivfa 661 rtspqqkliivegcqrqgaivavtgdgvndspalkkadigvamgiagsdvskqaadmill 721 ddnfasivtgveegrlifdnlkksiaytltsnipeitpflifiianiplplgtvtilcid 781 lgtdmvpaislayeqaesdimkrqprnpktdklvnerlismaygqigmiqalggfftyfv 841 ilaengflpihllglrvdwddrwindvedsygqqwtyeqrkiveftchtaffvsivvvqw 901 adlvicktrrnsvfqqgmknkilifglfeetalaaflsycpgmgvalrmyplkptwwfca 961 fpysllifvydevrkliirrrpggwveketyy GeneID: X3 Genesymbol: CD200 Genedescription: CD200molecule Unigene: Hs.79015 Genbank: AK297194|AF063591|BC022522|BC031103|AY603771|AK293399 EntrezGene: 4345 Refseq: NM_001004196|NM_005944 Proteinsequenceisoformb(SEQIDNO(5)): 1 merltltrtiggplltatllgkttindyqvirmpfshlstyslvwvmaavvlctaqvqvv 61 tqdereqlytpaslkcslqnaqealivtwqkkkavspenmvtfsenhgvviqpaykdkin 121 itqlglqnstitfwnitledegcymclfntfgfgkisgtacltvyvqpivslhykfsedh 181 lnitcsatarpapmvfwkvprsgienstvtlshpngttsvtsilhikdpknqvgkevicq 241 vlhlgtvtdfkqtvnkgywfsvplllsivslvillvlisillywkrhrnqdrep Proteinsequenceisoforma(SEQIDNO(6)): 1 merlvirmpfshlstyslvwvmaavvlctaqvqvvtqdereqlytpaslkcslqnaqeal 61 ivtwqkkkavspenmvtfsenhgvviqpaykdkinitqlglqnstitfwnitledegcym 121 clfntfgfgkisgtacltvyvqpivslhykfsedhlnitcsatarpapmvfwkvprsgie 181 nstvtlshpngttsvtsilhikdpknqvgkevicqvlhlgtvtdfkqtvnkgywfsvpll 241 lsivslvillvlisillywkrhrnqdrep GeneID: X4 Genesymbol: LAMB1 Genedescription: laminin,beta1 Unigene: Hs.650585 Genbank: M61916 EntrezGene: 3912 Refseq: NM_002291 Proteinsequence(SEQIDNO(7)): 1 mgllqllafsflalcrarvraqepefsygcaegscypatgdlligraqklsvtstcglhk 61 pepycivshlqedkkcficnsqdpyhetlnpdshlienvvttfapnrlkiwwqsengven 121 vtiqldleaefhfthlimtfktfrpaamlierssdfgktwgvyryfaydceasfpgistg 181 pmkkvddiicdsrysdiepstegevifraldpafkiedpyspriqnllkitnlrikfvkl 241 htlgdnlldsrmeirekyyyavydmvvrgncfcyghasecapvdgfneevegmvhghcmc 301 rhntkglncelcmdfyhdlpwrpaegrnsnackkcncnehsischfdmavylatgnvsgg 361 vcddcqhntmgrnceqckpfyyqhperdirdpnfcerctcdpagsqnegicdsytdfstg 421 liagqcrcklnvegehcdvckegfydissedpfgckscacnplgtipggnpcdsetghcy 481 ckrlvtgqhcdqclpehwglsndldgerpcdcdlggalnnscfaesgqcscrphmigrqc 541 nevepgyyfatldhylyeaeeanlgpgvsiverqyiqdripswtgagfvrvpegayleff 601 idnipysmeydiliryepqlpdhwekavitvqrpgriptssrcgntipdddnqvvslspg 661 sryvvlprpvcfekgtnytvrlelpqytssdsdvespytlidslvlmpycksldiftvgg 721 sgdgvvtnsawetfqryrclensrsvvktpmtdvcrniifsisallhqtglacecdpqgs 781 lssvcdpnggqcqcrpnvvgrtcnrcapgtfgfgpsgckpcechlqgsvnafcnpvtgqc 841 hcfqgvyarqcdrclpghwgfpscqpcqcnghaddcdpvtgeclncqdytmghncercla 901 gyygdpiigsgdherpcpcpdgpdsgrqfarscyqdpvtlqlacvcdpgyigsreddcas 961 gyfgnpsevggscqpcqchnnidttdpeacdketgrclkclyhtegehcqfcrfgyygda 1021 lqqdcrkcvcnylgtvqehcngsdcqcdkatgqclclpnvigqncdrcapntwqlasgtg 1081 cdpcncnaahsfgpscneftgqcqcmpgfggrtcsecqelfwgdpdvecracdcdprgie 1141 tpqcdqstgqcvcvegvegpredkctrgysgvfpdctpchqcfalwdviiaeltnrthrf 1201 lekakalkisgvigpyretvdsverkvseikdilaqspaaeplknignlfeeaeklikdv 1261 temmaqvevklsdttsqsnstakeldslqteaesldntvkelaeqlefiknsdirgalds 1321 itkyfqmsleaeervnasttepnstveqsalmrdrvedvmmeresqfkekqeeqarllde 1381 lagklqsldlsaaaemtcgtppgascsetecggpncrtdegerkcggpgcgglvtvahna 1441 wqkamdldqdvlsalaeveqlskmvseaklradeakqsaedillktnatkekmdksneel 1501 rnlikqirnfltqdsadldsieavanevlkmempstpqqlqnltedirerveslsqvevi 1561 lqhsaadiaraemlleeakrasksatdvkvtadmvkealeeaekaqvaaekaikqadedi 1621 qgtqnlltsiesetaaseetlfnasqriselernveelkrkaaqnsgeaeyiekvvytvk 1681 qsaedvkktldgeldekykkvenliakkteesadarrkaemlqneaktllaqansklqll 1741 kdlerkyednqryledkaqelarlegevrsllkdisqkvavystcl GeneID: X5 Genesymbol: CD248 Genedescription: endosialin Unigene: Hs.195727 Genbank: AF279142 EntrezGene: 57124 Refseq: NM_020404 Proteinsequence(SEQIDNO(8)): 1 mllrlllawaaagptlgqdpwaaepraacgpsscyalfprrrtfleawracrelggdlat 61 prtpeeaqrvdslvgagpasrllwiglqrqarqcqlqrplrgftwttgdqdtaftnwaqp 121 asggpcpaqrcvaleasgehrwlegsctlavdgylcqfgfegacpalqdeagqagpavyt 181 tpfhlvstefewlpfgsvaavqcqagrgasllcvkqpeggvgwsragplclgtgcspdng 241 gcehecveevdghvscrctegfrlaadgrscedpcaqapceqqcepggpqgyschcrlgf 301 rpaeddphrcvdtdecqiagvcqqmcvnyvggfecycsegheleadgiscspagamgaqa 361 sqdlgdellddgedeededeawkafnggwtempgilwmeptqppdfalayrpsfpedrep 421 qipypeptwppplsaprvpyhssvlsvtrpvvvsathptlpsahqppvipathpalsrdh 481 qipviaanypdlpsayqpgilsvshsaqppahqppmistkypelfpahqspmfpdtrvag 541 tqttthlpgippnhaplvttlgaqlppqapdalvlrtqatqlpiiptaqpsltttsrspv 601 spahqisvpaatqpaalptllpsqsptnqtspispthphskapqipredgpspklalwlp 661 spaptaaptalgeaglaehsqrddrwllvallvptcvflvvllalgivyctrcgphapnk 721 ritdcyrwvihagsksptepmpprgsltgvqtcrtsv GeneID: X6 Genesymbol: COL4A6 Genedescription: collagen,typeIV,alpha6 Unigene: Hs.145586 Genbank: D21337 EntrezGene: 1288 Refseq: NM_033641|NM_001847 Proteinsequenceisoformb(SEQIDNO(9)): 1 mhpglwlllvtlclteelaaageksygkpcggqdcsgscqcfpekgargrpgpigiqgpt 61 gpqgftgstglsglkgergfpgllgpygpkgdkgpmgvpgflgingipghpgqpgprgpp 121 gldgcngtqgavgfpgpdgypgllgppglpgqkgskgdpvlapgsfkgmkgdpglpgldg 181 itgpqgapgfpgavgpagppglqgppgppgplgpdgnmglgfqgekgvkgdvglpgpagp 241 ppstgelefmgfpkgkkgskgepgpkgfpgisgppgfpglgttgekgekgekgipglpgp 301 rgpmgsegvqgppgqqgkkgtlgfpglngfqgiegqkgdiglpgpdvfididgavisgnp 361 gdpgvpglpglkgdegiqglrgpsgvpglpalsgvpgalgpqgfpglkgdqgnpgrttig 421 aaglpgrdglpgppgppgppspefetetlhnkesgfpglrgeqgpkgnlglkgikgdsgf 481 cacdggvpntgppgepgppgpwgliglpglkgargdrgsggaqgpagapglvgplgpsgp 541 kgkkgepilstiqgmpgdrgdsgsqgfrgvigepgkdgvpglpglpglpgdggqgfpgek 601 glpglpgekghpgppglpgnglpglpgprglpgdkgkdglpgqqglpgskgitlpciipg 661 sygpsgfpgtpgfpgpkgsrglpgtpgqpgssgskgepgspglvhlpelpgfpgprgekg 721 lpgfpglpgkdglpgmigspglpgskgatgdifgaengapgeqglqgltghkgflgdsgl 781 pglkgvhgkpgllgpkgergspgtpgqvgqpgtpgssgpygikgksglpgapgfpgisgh 841 pgkkgtrgkkgppgsivkkglpglkglpgnpglvglkgspgspgvaglpalsgpkgekgs 901 vgfvgfpgipglpgipgtrglkgipgstgkmgpsgragtpgekgdrgnpgpvgipsprrp 961 msnlwlkgdkgsqgsagsngfpgprgdkgeagrpgppglpgapglpgiikgvsgkpgppg 1021 fmgirglpglkgssgitgfpgmpgesgsqgirgspglpgasglpglkgdngqtveisgsp 1081 gpkgqpgesgfkgtkgrdglignigfpgnkgedgkvgvsgdvglpgapgfpgvagmrgep 1141 glpgssghqgaigplgspgligpkgfpgfpglhglnglpgtkgthgtpgpsitgvpgpag 1201 lpgpkgekgypgigigapgkpglrgqkgdrgfpglqgpaglpgapgislpsliagqpgdp 1261 grpgldgergrpgpagppgppgpssnqgdtgdpgfpgipgpkgpkgdqgipgfsglpgel 1321 glkgmrgepgfmgtpgkvgppgdpgfpgmkgkagprgssglqgdpgqtptaeavqvppgp 1381 lglpgidgipgltgdpgaqgpvglqgskglpgipgkdgpsglpgppgalgdpglpglqgp 1441 pgfegapgqqgpfgmpgmpgqsmrvgytlvkhsqseqvppcpigmsqlwvgysllfvegq 1501 ekahnqdlgfagsclprfstmpfiycninevchyarrndksywlsttapipmmpvsqtqi 1561 pqyisrcsvceapsqaiavhsqditipqcplgwrslwigysflmhtaagaegggqslvsp 1621 gscledfratpfiecsgargtchyfankysfwlttveerqqfgelpvsetlkagqlhtrv 1681 srcqvcmksl Proteinsequenceisoforma(SEQIDNO(10)): 1 mlinklwlllvtlclteelaaageksygkpcggqdesgscqcfpekgargrpgpigiqgp 61 tgpqgftgstglsglkgergfpgllgpygpkgdkgpmgvpgflgingipghpgqpgprgp 121 pgldgcngtqgavgfpgpdgypgllgppglpgqkgskgdpvlapgsfkgmkgdpglpgld 181 gitgpqgapgfpgavgpagppglqgppgppgplgpdgnmglgfqgekgvkgdvglpgpag 241 pppstgelefmgfpkgkkgskgepgpkgfpgisgppgfpglgttgekgekgekgipglpg 301 prgpmgsegvqgppgqqgkkgtlgfpglngfqgiegqkgdiglpgpdvfididgavisgn 361 pgdpgvpglpglkgdegiqglrgpsgvpglpalsgvpgalgpqgfpglkgdqgnpgrtti 421 gaaglpgrdglpgppgppgppspefetetlhnkesgfpglrgeqgpkgnlglkgikgdsg 481 fcacdggvpntgppgepgppgpwgliglpglkgargdrgsggaqgpagapglvgplgpsg 541 pkgkkgepilstiqgmpgdrgdsgsqgfrgvigepgkdgvpglpglpglpgdggqgfpge 601 kglpglpgekghpgppglpgnglpglpgprglpgdkgkdglpgqqglpgskgitlpciip 661 gsygpsgfpgtpgfpgpkgsrglpgtpgqpgssgskgepgspglvhlpelpgfpgprgek 721 glpgfpglpgkdglpgmigspglpgskgatgdifgaengapgeqglqgltghkgflgdsg 781 lpglkgvhgkpgllgpkgergspgtpgqvgqpgtpgssgpygikgksglpgapgfpgisg 841 hpgkkgtrgkkgppgsivkkglpglkglpgnpglvglkgspgspgvaglpalsgpkgekg 901 svgfvgfpgipglpgipgtrglkgipgstgkmgpsgragtpgekgdrgnpgpvgipsprr 961 pmsnlwlkgdkgsqgsagsngfpgprgdkgeagrpgppglpgapglpgiikgvsgkpgpp 1021 gfmgirglpglkgssgitgfpgmpgesgsqgirgspglpgasglpglkgdngqtveisgs 1081 pgpkgqpgesgfkgtkgrdglignigfpgnkgedgkvgvsgdvglpgapgfpgvagmrge 1141 pglpgssghqgaigplgspgligpkgfpgfpglhginglpgtkgthgtpgpsitgvpgpa 1201 glpgpkgekgypgigigapgkpglrgqkgdrgfpglqgpaglpgapgislpsliagqpgd 1261 pgrpgldgergrpgpagppgppgpssnqgdtgdpgfpgipgpkgpkgdqgipgfsglpge 1321 lglkgmrgepgfmgtpgkvgppgdpgfpgmkgkagprgssglqgdpgqtptaeavqvppg 1381 plglpgidgipgltgdpgaqgpvglqgskglpgipgkdgpsglpgppgalgdpglpglqg 1441 ppgfegapgqqgpfgmpgmpgqsmrvgytlvkhsqseqvppcpigmsqlwvgysllfveg 1501 qekahnqdlgfagsclprfstmpfiycninevchyarrndksywlsttapipmmpvsqtq 1561 ipqyisrcsvceapsqaiavhsqditipqcplgwrslwigysflmhtaagaegggqslvs 1621 pgscledfratpfiecsgargtchyfankysfwlttveerqqfgelpvsetlkagqlhtr 1681 vsrcqvcmksl GeneID: X7 Genesymbol: PCDH7 Genedescription: protocadherin7 Unigene: Hs.479439|Hs.724529 Genbank: AB006755 EntrezGene: 5099 Refseq: NM_032456|NM_002589|NM_032457|NM_001173523 Proteinsequenceisoformb(SEQIDNO(11)): 1 mlrmrtagwargwclgcclllplslslaaakqllryrlaeegpadvrignvasdlgivtg 61 sgevtfslesgseylkidnltgelstserridreklpqcqmifdenecfldfevsvigps 121 qswvdlfegqvivldindntptfpspvltltveenrpvgtlyllptatdrdfgrngiery 181 ellqepggggsggesrragaadsapypggggngasgggsggskrrldaseggggtnpggr 241 ssvfelqvadtpdgekqpqlivkgaldreqrdsyeltlrvrdggdpprssqailmvlitd 301 vndnsprfeksvyeadlaensapgtpilqlraadldvgvngqieyvfgaatesvrrllrl 361 detsgwlsvlhridreevnqlrftvmardrgqppktdkatvvlnikdendnvpsieirki 421 griplkdgvanvaedvlvdtpialvqvsdrdqgengvvtctwvgdvpfqlkpasdtegdq 481 nkkkyflhtstpldyeatrefnvvivavdsgspslssnnslivkvgdtndnppmfgqsvv 541 evyfpennipgervatvlatdadsgknaeiaysldssvmgifaidpdsgdilvntvldre 601 qtdryefkvnakdkgipvlqgsttvivqvadkndndpkfmqdvftfyvkenlqpnspvgm 661 vtvmdadkgrnaemslyieennnifsiendtgtiystmsfdrehqttytfrvkavdggdp 721 prsatatvslfvmdendnaptvtlpknisytllppssnvrtvvatvlatdsddginadln 781 ysivggnpfklfeidptsgvvslvgkltqkhyglhrlvvqvndsgqpsqstttlvhvfvn 841 esvsnataidsqiarslhipltqdiagdpsyeiskqrlsivigvvagimtviliilivvm 901 arycrsknkngyeagkkdhedfftpqqhdkskkpkkdkknkkskqplyssivtveaskpn 961 gqrydsvneklsdspsmgryrsvnggpgspdlarhyksssplptvqlhpqsptagkkhqa 1021 vqdlppantfvgagdnisigsdhcseyscqtnnkyskqvrcipnifkypreg Proteinsequenceisoforma(SEQIDNO(12)): 1 mlrmrtagwargwclgcclllplslslaaakqllrynlaeegpadvrignvasdlgivtg 61 sgevtfslesgseylkidnltgelstserridreklpqcqmifdenecfldfevsvigps 121 qswvdlfegqvivldindntptfpspvltltveenrpvgtlyllptatdrdfgrngiery 181 ellqepggggsggesrragaadsapypggggngasgggsggskrrldaseggggtnpggr 241 ssvfelqvadtpdgekqpqlivkgaldreqrdsyeltlrvrdggdpprssqailrvlitd 301 vndnsprfeksvyeadlaensapgtpilqlraadldvgvngqieyvfgaatesvrrllrl 361 detsgwlsvlhridreevnqlrftvmardrgqppktdkatvvlnikdendnvpsieirki 421 griplkdgvanvaedvlvdtpialvqvsdrdqgengvvtctwvgdvpfqlkpasdtegdq 481 nkkkyflhtstpldyeatrefnvvivavdsgspslssnnslivkvgdtndnppmfgqsvv 541 evyfpennipgervatvlatdadsgknaeiaysldssvmgifaidpdsgdilvntvldre 601 qtdryefkvnakdkgipvlqgsttvivqvadkndndpkfmqdvftfyvkenlqpnspvgm 661 vtvmdadkgrnaemslyieennnifsiendtgtiystmsfdrehqttytfrvkavdggdp 721 prsatatvslfvmdendnaptvtlpknisytllppssnvrtvvatvlatdsddginadln 781 ysivggnpfklfeidptsgvvslvgkltqkhyglhrlwvqvndsgqpsqstttlvhvfvn 841 esvsnataidsqiarslhipltqdiagdpsyeiskqrlsivigvvagimtviliilivvm 901 arycrsknkngyeagkkdhedfftpqqhdkskkpkkdkknkkskqplyssivtveaskpn 961 gqrydsvneklsdspsmgryrsvnggpgspdlarhyksssplptvqlhpqsptagkkhqa 1021 vqdlppantfvgagdnisigsdhcseyscqtnnkyskqmrlhpyitvfg Proteinsequenceisoformc(SEQIDNO(13)): 1 mlrmrtagwargwclgcclllplslslaaakqllrynlaeegpadvrignvasdlgivtg 61 sgevtfslesgseylkidnltgelstserridreklpqcqmifdenecfldfevsvigps 121 qswvdlfegqvivldindntptfpspvltltveenrpvgtlyllptatdrdfgrngiery 181 ellqepggggsggesrragaadsapypggggngasgggsggskrrldaseggggtnpggr 241 ssvfelqvadtpdgekqpqlivkgaldreqrdsyeltlrvrdggdpprssqailrvlitd 301 vndnsprfeksvyeadlaensapgtpilqlraadldvgvngqieyvfgaatesvrrllrl 361 detsgwlsvlhridreevnqlrftvmardrgqppktdkatvvlnikdendnvpsieirki 421 griplkdgvanvaedvlvdtpialvqvsdrdqgengvvtctvvgdvpfqlkpasdtegdq 481 nkkkyflhtstpldyeatrefnvvivavdsgspslssnnslivkvgdtndnppmfgqsvv 541 evyfpennipgervatvlatdadsgknaeiaysldssvmgifaidpdsgdilvntvldre 601 qtdryefkvnakdkgipvlqgsttvivqvadkndndpkfmqdvftfyvkenlqpnspvgm 661 vtvmdadkgrnaemslyieennnifsiendtgtiystmsfdrehqttytfrvkavdggdp 721 prsatatvslfvmdendnaptvtlpknisytllppssnvrtvvatvlatdsddginadln 781 ysivggnpfklfeidptsgvvslvgkltqkhyglhrlvvqvndsgqpsqstttlvhvfvn 841 esvsnataidsqiarslhipltqdiagdpsyeiskqrlsivigvvagimtviliilivvm 901 arycrsknkngyeagkkdhedfftpqqhdkskkpkkdkknkkskqplyssivtveaskpn 961 gqrydsvneklsdspsmgryrsvnggpgspdlarhyksssplptvqlhpqsptagkkhqa 1021 vqdlppantfvgagdnisigsdhcseyscqtnnkyskqpfrrvtfsvvsqpqdphqgslq 1081 scydsgleesetpssksssgprlgalplpednyerttpdgsvdsrplpdvaltgkctrec 1141 deyghsdscwmpvrtsperkksqpklstfmpvdergsqeklangeaaimgdrnrnllnkk 1201 ltssyetfsaasfskneeanpedipltktgeykpspvntltrrevyl Proteinsequenceisoformd(SEQIDNO(14)): 1 mlrmrtagwargwclgcclllplslslaaakqllryrlaeegpadvrignvasdlgivtg 61 sgevtfslesgseylkidnltgelstserridreklpqcqmifdenecfldfevsvigps 121 qswvdlfegqvivldindntptfpspvltltveenrpvgtlyllptatdrdfgrngiery 181 ellqepggggsggesrragaadsapypggggngasgggsggskrrldaseggggtnpggr 241 ssvfelqvadtpdgekqpqlivkgaldreqrdsyeltlrvrdggdpprssqailrvlitd 301 vndnsprfeksvyeadlaensapgtpilqlraadldvgvngqieyvfgaatesvrrllrl 361 detsgwlsvlhridreevnqlrftvmardrgqppktdkatvvlnikdendnvpsieirki 421 griplkdgvanvaedvlvdtpialvqvsdrdqgengvvtctvvgdvpfqlkpasdtegdq 481 nkkkyflhtstpldyeatrefnvvivavdsgspslssnnslivkvgdtndnppmfgqswv 541 evyfpennipgervatvlatdadsgknaeiaysldssvmgifaidpdsgdilvntvldre 601 qtdryefkvnakdkgipvlqgsttvivqvadkndndpkfmqdvftfyvkenlqpnspvgm 661 vtvmdadkgrnaemslyieennnifsiendtgtiystmsfdrehqttytfrvkavdggdp 721 prsatatvslfvmdendnaptvtlpknisytllppssnvrtvvatvlatdsddginadln 781 ysivggnpfklfeidptsgvvslvgkltqkhyglhrlvvqvndsgqpsqstttlvhvfvn 841 esvsnataidsqiarslhipltqdiagdpsyeiskqrlsivigvvagimtviliilivvm 901 arycrsknkngyeagkkdhedfftpqqhdkskkpkkdkknkkskqplyssivtveaskpn 961 gqrydsvneklsdspsmgryrsvnggpgspdlarhyksssplptvqlhpqsptagkkhqa 1021 vqdlppantfvgagdnisigsdhcseyscqtnnkyskqpfrrvtfsvvsqpqdphqgslq 1081 scydsgleesetpssksssgprlgalplpednyerttpdgsvgeaehmendsrplpdval 1141 tgkctrecdeyghsdscwmpvrtsperkksqpklstfmpvdergsqeklangeaaimgdr 1201 nrnllnkkltssyetfsaasfskneeanpedipltktgeykpspvntltrrevyl GeneID: X8 Genesymbol: NOG Genedescription: noggin Unigene: Hs.248201 Genbank: BC034027 EntrezGene: 9241 Refseq: NM_005450 Proteinsequence(SEQIDNO(15)): 1 mercpslgvtlyalvvvlglratpaggqhylhirpapsdnlplvdliehpdpifdpkekd 61 lnetllrsllgghydpgfmatsppedrpgggggaaggaedlaeldqllrqrpsgampsei 121 kglefseglaqgkkqrlskklrrklqmwlwsqtfcpvlyawndlgsrfwpryvkvgscfs 181 krscsvpegmvckpsksvhltvlrwrcqrrggqrcgwipiqypiiseckcsc GeneID: X9 Genesymbol: SULF1 Genedescription: sulfatase1 Unigene: Hs.409602 Genbank: AF545571 EntrezGene: 23213 Refseq: NM_001128205|NM_015170|NM_001128206|NM_001128204 Proteinsequence(SEQIDNO(16)): 1 mkysccalvlavlgtellgslcstvrsprfrgriqqerknirpniilvitddqdvelgsl 61 qvmnktrkimehggatfinafvttpmccpsrssmitgkyvhnhnvytnnencsspswqam 121 heprtfavylnntgyrtaffgkylneyngsyippgwrewlgliknsrfynytvcrngike 181 khgfdyakdyftdlitnesinyfkmskrmyphrpvmmvishaaphgpedsapqfsklypn 241 asqhitpsynyapnmdkhwimqytgpmlpihmeftnilqrkriqtlmsvddsverlynml 301 vetgelentyiiytadhgyhigqfglvkgksmpydfdirvpffirgpsvepgsivpqivl 361 nidlaptildiagldtppdvdgksvlklldpekpgnrfrtnkkakiwrdtflvergkflr 421 kkeesskniqqsnhlpkyervkelcqqaryqtaceqpgqkwqciedtsgklrihkckgps 481 dlltvrqstrnlyargfhdkdkecscresgyrasrsqrksqrqflrnqgtpkykprfvht 541 rqtrslsvefegeiydinleeeeelqvlqprniakrhdeghkgprdlqassggnrgrmla 601 dssnavgppttvrvthkcfilpndsihcerelyqsarawkdhkayidkeiealqdkiknl 661 revrghlkrrkpeecscskqsyynkekgvkkqeklkshlhpfkeaaqevdsklqlfkenn 721 rrrkkerkekrrqrkgeecslpgltcfthdnnhwqtapfwnlgsfcactssnnntywclr 781 tvnethnflfcefatgfleyfdmntdpyqltntvhtvergilnqlhvqlmelrscqgykq 841 cnprpknldvgnkdggsydlhrgqlwdgweg GeneID: X10 Genesymbol: SORT1 Genedescription: sortilin1 Unigene: Hs.485195 Genbank: X98248 EntrezGene: 6272 Refseq: NM_002959|NM_001205228 Proteinsequenceisoform1(SEQIDNO(17)): 1 merpwgaadglsrwphglglllllqllppstlsqdrldappppaaplprwsgpigvswgl 61 raaaaggafprggrwrrsapgedeecgrvrdfvaklannthqhvfddlrgsvslswvgds 121 tgvilvlttfhvplvimtfgqsklyrsedygknfkditdlinntfirtefgmaigpensg 181 kwvltaevsggsrggrifrssdfaknfvqtdlpfhpltqmmyspqnsdyllalstenglw 241 vsknfggkweeihkavclakwgsdntiffttyangsckadlgalelwrtsdlgksfktig 301 vkiysfglggrflfasvmadkdttrrihvstdqgdtwsmaqlpsvgqeqfysilaanddm 361 vfmhvdepgdtgfgtiftsddrgivysksldrhlytttggetdftnvtslrgvyitsvls 421 ednsiqtmitfdqggrwthlrkpensecdataknknecslhihasysisqklnvpmapls 481 epnavgiviahgsvgdaisvmvpdvyisddggyswtkmlegphyytildsggiivaiehs 541 srpinvikfstdegqcwqtytftrdpiyftglasepgarsmnisiwgftesfltsqwvsy 601 tidfkdilernceekdytiwlahstdpedyedgcilgykeqflrlrkssvcqngrdyvvt 661 kqpsiclcsledflcdfgyyrpendskcveqpelkghdlefclygreehlttngyrkipg 721 dkcqggvnpvrevkdlkkkctsnflspekqnsksnsvpiilaivglmlvtvvagvlivkk 781 yvcggrflvhrysvlqqhaeangvdgvdaldtashtnksgyhddsdedlle Proteinsequenceisoform2(SEQIDNO(18)): 1 mtfgqsklyrsedygknfkditdlinntfirtefgmaigpensgkvvltaevsggsrggr 61 ifrssdfaknfvqtdlpfhpltqmmyspqnsdyllalstenglwvsknfggkweeihkav 121 clakwgsdntiffttyangsctdlgalelwrtsdlgksfktigvkiysfglggrflfasv 181 madkdttrrihvstdqgdtwsmaqlpsvgqeqfysilaanddmvfmhvdepgdtgfgtif 241 tsddrgivysksldrhlytttggetdftnvtslrgvyitsvlsednsiqtmitfdqggrw 301 thlrkpensecdataknknecslhihasysisqklnvpmaplsepnavgiviahgsvgda 361 isvmvpdvyisddggyswtkmlegphyytildsggiivaiehssrpinvikfstdegqcw 421 qtytftrdpiyftglasepgarsmnisiwgftesfltsqwvsytidfkdilernceekdy 481 tiwlahstdpedyedgcilgykeqflrlrkssveqngrdyvvtkqpsiclcsledflcdf 541 gyyrpendskcveqpelkghdlefclygreehlttngyrkipgdkcqggvnpvrevkdlk 601 kkctsnflspekqnsksnsvpiilaivglmlvtvvagvlivkkyvcggrflvhrysvlqq 661 haeangvdgvdaldtashtnksgyhddsdedlle GeneID: X11 Genesymbol: ATP1B1 Genedescription: sodium/potassium-transportingATPasesubunitbeta-1 Unigene: Hs.291196 Genbank: U16799 EntrezGene: 481 Refseq: NM_001677 Proteinsequence(SEQIDNO(19)): 1 margkakeegswkkfiwnsekkeflgrtggswfkillfyvifygclagifigtiqvmllt 61 isefkptyqdrvappgltqipqiqkteisfrpndpksyeayvlnivrflekykdsaqrdd 121 mifedcgdvpsepkergdfnhergerkvcrfklewlgncsglndetygykegkpciiikl 181 nrvlgfkpkppknesletypvmkynpnvlpvqctgkrdedkdkvgnveyfglgnspgfpl 241 qyypyygkllqpkylqpllavqftnltmdteirieckaygenigysekdrfqgrfdvkie 301 vks GeneID: X12 Genesymbol: AGRN Genedescription: Agrin Unigene: Hs.273330 Genbank: AB191264 EntrezGene: 375790 Refseq: NM_198576 Proteinsequence(SEQIDNO(20)): 1 magrshpgplrpllpllvvaacvlpgaggtcperalerreeeanwvltgtveeilnvdpv 61 qhtysckvrvwrylkgkdlvareslldggnkvvisgfgdplicdnqvstgdtriffvnpa 121 ppylwpahknelmlnsslmritlrnleevefcvedkpgthftpvpptppdacrgmlcgfg 181 avcepnaegpgrascvckkspcpsvvapvcgsdastysnecelqraqcsqqrrirllsrg 241 pcgsrdpcsnvtcsfgstcarsadgltasclcpatcrgapegtvcgsdgadypgecqllr 301 racarqenvfkkfdgpcdpcqgalpdpsrscrvnprtrrpemllrpescparqapvcgdd 361 gvtyendcvmgrsgaarglllqkvrsgqcqgrdqcpeperfnavelsrrgrprescdrvt 421 cdgayrpvcaqdgrtydsdcwrqqaecrqqraipskhqgpcdqapspclgvqcafgatca 481 vkngqaaceclqacsslydpvcgsdgvtygsaceleatactlgreiqvarkgpedregqc 541 rfgalceaetgrcvcpsecvalaqpvcgsdghtypsecmlhvhacthqislhvasagpce 601 tcgdavcafgavcsagqcvcprcehpppgpvcgsdgvtygsacelreaaclqqtqieear 661 agpceqaecgsggsgsgedgdceqelcrqrggiwdedsedgpcvcdfscqsvpgspvcgs 721 dgvtystecelkkarcesqrglyvaaqgacrgptfaplppvaplhcaqtpygccqdnita 781 argvglagcpsacqcnphgsyggtcdpatgqcscrpgvgglrcdrcepgfwnfrgivtdg 841 rsgctpcscdpqgavrddceqmtglcsckpgvagpkcgqcpdgralgpagceadasapat 901 caemrcefgareveesgsahcvcpmltcpeanatkvcgsdgvtygnecqlktiacrqglq 961 isiqslgpcqeavapsthptsasvtvttpglllsqalpappgalplapsstahsqttppp 1021 ssrprttasvprttvwpvltvpptapspapslvasafgesgstdgssdeelsgdqeasgg 1081 gsggleplegssvatpgppverascynsalgccsdgktpsldaegsncpatkvfqgvlel 1141 egvegqelfytpemadpkselfgetarsiestlddlfrnsdvkkdfrsvrlrdlgpgksv 1201 raivdvhfdpttafrapdvarallrqiqvsrrrslgvrrplqehvrfmdfdwfpafitga 1261 tsgaiaagatarattasrlpssavtpraphpshtsqpvakttaapttrrppttapsrvpg 1321 rrppapqqppkpcdsqpcfhggtcqdwalgggftcscpagrggavcekvlgapvpafegr 1381 sflafptirayhtlrlalefralepqglllyngnargkdflalalldgrvqlrfdtgsgp 1441 avltsavpvepgqwhrlelsrhwrrgtlsvdgetpvlgespsgtdglnldtdlfvggvpe 1501 dqaavalertfvgaglrgcirlldvnnqrlelgigpgaatrgsgvgecgdhpclpnpchg 1561 gapcqnleagrfhcqcppgrvgptcadekspcqpnpchgaapcrvlpeggaqcecplgre 1621 gtfcqtasgqdgsgpfladfngfshlelrglhtfardlgekmalevvflargpsglllyn 1681 gqktdgkgdfvslalrdrrlefrydlgkgaavirsrepvtlgawtrvslerngrkgalrv 1741 gdgprvlgespvphtvinikeplyvggapdfsklaraaavssgfdgaiqlvslggrqllt 1801 pehvlrqvdvtsfaghpctrasghpclngascvpreaayvclcpggfsgphcekglveks 1861 agdvdtlafdgrtfveylnavtesekalqsnhfelslrteatqglvlwsgkateradyva 1921 laivdghlqlsynlgsqpvvlrstvpvntnrwlrvvahreqregslqvgneapvtgsspl 1981 gatqldtdgalwlgglpelpvgpalpkaygtgfvgclrdvvvgrhplhlledavtkpelr 2041 pcptp GeneID: X13 Genesymbol: APP Genedescription: AmyloidbetaA4protein Unigene: Hs.434980 Genbank: BC065529|AF282245|AK298861|AK294534|AK295621|AK296229|AK297412| AK297229|AK295373|BC004369|M16765|AK311717 EntrezGene: 351 Refseq: NM_000484|NM_201413|NM_001136130|NM_201414|NM_001136129 Proteinsequenceisoforma(SEQIDNO(21)): 1 mlpglallllaawtaralevptdgnagllaepqiamfcgrlnmhmnvqngkwdsdpsgtk 61 tcidtkegilqycqevypelqitnvveanqpvtiqnwckrgrkqckthphfvipyrclvg 121 efvsdallvpdkckflhqermdvcethlhwhtvaketcsekstnlhdygmllpcgidkfr 181 gvefvccplaeesdnvdsadaeeddsdvwwggadtdyadgsedkvvevaeeeevaeveee 241 eadddeddedgdeveeeaeepyeeaterttsiatttttttesveevvrevcseqaetgpc 301 ramisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsamsqsllkttqeplard 361 pvklpttaastpdavdkyletpgdenehahfqkakerleakhrermsqvmreweeaerqa 421 knlpkadkkaviqhfqekvesleqeaanerqqlvethmarveamlndrrrlalenyital 481 qavpprprhvfnmlkkyvraeqkdrqhtlkhfehvrmvdpkkaaqirsqvmthlrviyer 541 mnqslsllynvpavaeeiqdevdellqkeqnysddvlanmiseprisygndalmpsltet 601 kttvellpvngefslddlqpwhsfgadsvpantenevepvdarpaadrglttrpgsgltn 661 ikteeisevkmdaefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvviatvivitl 721 vmlkkkqytsihhgvvevdaavtpeerhlskmqqngyenptykffeqmqn Proteinsequenceisoformb(SEQIDNO(22)): 1 mlpglallllaawtaralevptdgnagllaepqiamfcgrlnmhmnvqngkwdsdpsgtk 61 tcidtkegilqycqevypelqitnvveanqpvtiqnwckrgrkqckthphfvipyrclvg 121 efvsdallvpdkckflhqermdvcethlhwhtvaketcsekstnlhdygmllpcgidkfr 181 gvefvccplaeesdnvdsadaeeddsdvwwggadtdyadgsedkvvevaeeeevaeveee 241 eadddeddedgdeveeeaeepyeeaterttsiatttttttesveevvrevcseqaetgpc 301 ramisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsaipttaastpdavdkyl 361 etpgdenehahfqkakerleakhrermsqvmreweeaerqaknlpkadkkaviqhfqekv 421 eslegeaanerqqlvethmarveamlndrrrlalenyitalqavpprprhvfnmlkkyvr 481 aeqkdrqhtlkhfehvrmvdpkkaaqirsqvmthlrviyermnqslsllynvpavaeeiq 541 devdellqkeqnysddvlanmiseprisygndalmpsltetkttvellpvngefslddlq 601 pwhsfgadsvpantenevepvdarpaadrglttrpgsgltnikteeisevkmdaefrhds 661 gyevhhqklvffaedvgsnkgaiiglmvggvviatvivitlvmlkkkqytsihhgvvevd 721 aavtpeerhlskmqqngyenptykffeqmqn Proteinsequenceisoformf(SEQIDNO(23)): 1 mlpglallllaawtaralevypelqitnvveanqpvtiqnwckrgrkqckthphfvipyr 61 clvgefvsdallvpdkckflhqermdvcethlhwhtvaketcsekstnlhdygmllpcgi 121 dkfrgvefvccplaeesdnvdsadaeeddsdvwwggadtdyadgsedkvvevaeeeevae 181 veeeeadddeddedgdeveeeaeepyeeaterttsiatttttttesveevvrevcseqae 241 tgpcramisrwyfdvtegkcapffyggcggnrnnfdteeycmavcgsamsqsllkttqep 301 lardpvklpttaastpdavdkyletpgdenehahfqkakerleakhrermsqvmreweea 361 erqaknlpkadkkaviqhfqekvesleqeaanerqqlvethmarveamlndrrrlaleny 421 italqavpprprhvfnmlkkyvraeqkdrqhtlkhfehvrmvdpkkaaqirsqvmthlrv 481 iyermnqslsllynvpavaeeiqdevdellqkeqnysddvlanmiseprisygndalmps 541 ltetkttvellpvngefslddlqpwhsfgadsvpantenevepvdarpaadrglttrpgs 601 gltnikteeisevkmdaefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvviatvi 661 vitlvmlkkkqytsihhgvvevdaavtpeerhlskmqqngyenptykffeqmqn Proteinsequenceisoformc(SEQIDNO(24)): 1 mlpglallllaawtaralevptdgnagllaepqiamfcgrlnmhmnvqngkwdsdpsgtk 61 tcidtkegilqycqevypelqitnvveanqpvtiqnwckrgrkqckthphfvipyrclvg 121 efvsdallvpdkckflhqermdvcethlhwhtvaketcsekstnlhdygmllpcgidkfr 181 gvefvccplaeesdnvdsadaeeddsdvwwggadtdyadgsedkvvevaeeeevaeveee 241 eadddeddedgdeveeeaeepyeeaterttsiatttttttesveevvrvpttaastpdav 301 dkyletpgdenehahfqkakerleakhrermsqvmreweeaerqaknlpkadkkaviqhf 361 qekvesleqeaanerqqlvethmarveamlndrrrlalenyitalqavpprprhvfnmlk 421 kyvraeqkdrqhtlkhfehvrmvdpkkaaqirsqvmthlrviyermnqslsllynvpava 481 eeiqdevdellqkeqnysddvlanmiseprisygndalmpsltetkttvellpvngefsl 541 ddlqpwhsfgadsvpantenevepvdarpaadrglttrpgsgltnikteeisevkmdaef 601 rhdsgyevhhqklvffaedvgsnkgaiiglmvggvviatvivitlvmlkkkqytsihhgv 661 vevdaavtpeerhlskmqqngyenptykffeqmqn Proteinsequenceisoforme(SEQIDNO(25)): 1 mlpglallllaawtaralevypelqitnvveanqpvtiqnwckrgrkqckthphfvipyr 61 clvgefvsdallvpdkckflhqermdvcethlhwhtvaketcsekstnlhdygmllpcgi 121 dkfrgvefvccplaeesdnvdsadaeeddsdvwwggadtdyadgsedkvvevaeeeevae 181 veeeeadddeddedgdeveeeaeepyeeaterttsiatttttttesveevvrvpttaast 241 pdavdkyletpgdenehahfqkakerleakhrermsqvmreweeaerqaknlpkadkkav 301 iqhfqekvesleqeaanerqqlvethmarveamlndrrrlalenyitalqavpprprhvf 361 nmlkkyvraeqkdrqhtlkhfehvrmvdpkkaaqirsqvmthlrviyermnqslsllynv 421 pavaeeiqdevdellqkeqnysddvlanmiseprisygndalmpsltetkttvellpvng 481 efslddlqpwhsfgadsvpantenevepvdarpaadrglttrpgsgltnikteeisevkm 541 daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvviatvivitlvmlkkkqytsi 601 hhgvvevdaavtpeerhlskmqqngyenptykffeqmqn GeneID: X14 Genesymbol: COLEC12 Genedescription: Collectinsub-familymember12 Unigene: Hs.464422 Genbank: AB038518 EntrezGene: 81035 Refseq: NM_130386 Proteinsequence(SEQIDNO(26)): 1 mkddfaeeeevqsfgykrfgiqegtqctkcknnwalkfsiillyilcalltitvailgyk 61 vvekmdnvtggmetsrqtyddkltavesdlkklgdqtgkkaistnselstfrsdildlrq 121 qlreitektsknkdtleklqasgdalvdrqsqlketlennsflittvnktlqayngyvtn 181 lqqdtsviqgnlqnqmyshnvvimnlnnlnltqvqqrnlitnlqrsvddtsqaiqriknd 241 fqnlqqvflqakkdtdwlkekvqslqtlaannsalakanndtledmnsqlnsftgqmeni 301 ttisqaneqnlkdlqdlhkdaenrtaikfnqleerfqlfetdivniisnisytahhlrtl 361 tsnlnevrttctdtltkhtddltslnntlanirldsvslrmqqdlmrsrldtevanlsvi 421 meemklvdskhgqliknftilqgppgprgprgdrgsqgppgptgnkgqkgekgepgppgp 481 agergpigpagppgerggkgskgsqgpkgsrgspgkpgpqgpsgdpgppgppgkeglpgp 541 qgppgfqglqgtvgepgvpgprglpglpgvpgmpgpkgppgppgpsgavvplalqneptp 601 apedngcpphwknftdkcyyfsvekeifedaklfcedksshlvfintreeqqwikkqmvg 661 reshwigltdserenewkwldgtspdyknwkagqpdnwghghgpgedcagliyagqwndf 721 qcedvnnficekdretvlssal GeneID: X15 Genesymbol: NCAM1 Genedescription: Neuralcelladhesionmolecule1 Unigene: Hs.503878 Genbank: BC047244 EntrezGene: 4684 Refseq: NM_000615|NM_001076682|NM_181351|NM_001242608| NM_001242607 Proteinsequenceisoform1(SEQIDNO(27)): 1 mlqtkdliwtlfflgtavslqvdivpsqgeisvgeskfflcqvagdakdkdiswfspnge 61 kltpnqqrisvvwnddssstltiynaniddagiykcvvtgedgseseatvnvkifqklmf 121 knaptpqefregedavivcdvvsslpptiiwkhkgrdvilkkdvrfivlsnnylqirgik 181 ktdegtyrcegrilargeinfkdiqvivnvpptiqarqnivnatanlgqsvtlvcdaegf 241 peptmswtkdgeqieqeeddekyifsddssqltikkvdkndeaeyiciaenkageqdati 301 hlkvfakpkityvenqtameleeqvtltceasgdpipsitwrtstrnisseektldghmv 361 vrsharvssltlksiqytdageyictasntigqdsqsmylevqyapklqgpvavytwegn 421 qvnitcevfaypsatiswfrdgqllpssnysnikiyntpsasylevtpdsendfgnynct 481 avnrigqeslefilvqadtpsspsidqvepysstaqvqfdepeatggvpilkykaewrav 541 geevwhskwydakeasmegivtivglkpettyavrlaalngkglgeisaasefktqpvqg 601 epsapklegqmgedgnsikvnlikqddggspirhylvryralssewkpeirlpsgsdhvm 661 lksldwnaeyevyvvaenqqgkskaahfvfrtsaqptaipangsptsglstgaivgiliv 721 ifvlllvvvditcyflnkcglfmciavnlcgkagpgakgkdmeegkaafskdeskepive 781 vrteeertpnhdggkhtepnettpltepekgpveakpecqetetkpapaevktvpndatq 841 tkeneska Proteinsequenceisoform3(SEQIDNO(28)): 1 mlqtkdliwtlfflgtavslqvdivpsqgeisvgeskfflcqvagdakdkdiswfspnge 61 kltpnqqrisvvwnddssstltiynaniddagiykcvvtgedgseseatvnvkifqklmf 121 knaptpqefregedavivcdvvsslpptiiwkhkgrdvilkkdvrfivlsnnylqirgik 181 ktdegtyrcegrilargeinfkdiqvivnvpptiqarqnivnatanlgqsvtlvcdaegf 241 peptmswtkdgeqieqeeddekyifsddssqltikkvdkndeaeyiciaenkageqdati 301 hlkvfakpkityvenqtameleeqvtltceasgdpipsitwrtstrnisseektldghmv 361 vrsharvssltlksiqytdageyictasntigqdsqsmylevqyapklqgpvavytwegn 421 qvnitcevfaypsatiswfrdgqllpssnysnikiyntpsasylevtpdsendfgnynct 481 avnrigqeslefilvqadtpsspsidqvepysstaqvqfdepeatggvpilkykaewrav 541 geevwhskwydakeasmegivtivglkpettyavrlaalngkglgeisaasefktqpvhs 601 ppppasassstpvplsppdttwplpalattepakgepsapklegqmgedgnsikvnlikq 661 ddggspirhylvryralssewkpeirlpsgsdhvmlksldwnaeyevyvvaenqqgkska 721 ahfvfrtsaqptaipatlggnsasytfvsllfsavtllllc Proteinsequenceisoform2(SEQIDNO(29)): 1 mlqtkdliwtlfflgtavslqvdivpsqgeisvgeskfflcqvagdakdkdiswfspnge 61 kltpnqqrisvvwnddssstltiynaniddagiykcvvtgedgseseatvnvkifqklmf 121 knaptpqefregedavivcdvvsslpptiiwkhkgrdvilkkdvrfivlsnnylqirgik 181 ktdegtyrcegrilargeinfkdiqvivnvpptiqarqnivnatanlgqsvtlvcdaegf 241 peptmswtkdgeqieqeeddekyifsddssqltikkvdkndeaeyiciaenkageqdati 301 hlkvfakpkityvenqtameleeqvtltceasgdpipsitwrtstrnisseekaswtrpe 361 kqetldghmvvrsharvssltlksiqytdageyictasntigqdsqsmylevqyapklqg 421 pvavytwegnqvnitcevfaypsatiswfrdgqllpssnysnikiyntpsasylevtpds 481 endfgnynctavnrigqeslefilvqadtpsspsidqvepysstaqvqfdepeatggvpi 541 lkykaewravgeevwhskwydakeasmegivtivglkpettyavrlaalngkglgeisaa 601 sefktqpvqgepsapklegqmgedgnsikvnlikqddggspirhylvryralssewkpei 661 rlpsgsdhvmlksldwnaeyevyvvaenqqgkskaahfvfrtsaqptaipangsptsgls 721 tgaivgilivifvlllvvvditcyflnkcglfmciavnlcgkagpgakgkdmeegkaafs 781 kdeskepivevrteeertpnhdggkhtepnettpltepekgpveakpecqetetkpapae 841 vktvpndatqtkeneska Proteinsequenceisoform4(SEQIDNO(30)): 1 mlqtkdliwtlfflgtavslqvdivpsqgeisvgeskfflcqvagdakdkdiswfspnge 61 kltpnqqrisvvwnddssstltiynaniddagiykcvvtgedgseseatvnvkifqklmf 121 knaptpqefregedavivcdvvsslpptiiwkhkgrdvilkkdvrfivlsnnylqirgik 181 ktdegtyrcegrilargeinfkdiqvivnvpptiqarqnivnatanlgqsvtlvcdaegf 241 peptmswtkdgeqieqeeddekyifsddssqltikkvdkndeaeyiciaenkageqdati 301 hlkvfakpkityvenqtameleeqvtltceasgdpipsitwrtstrnisseektldghmv 361 vrsharvssltlksiqytdageyictasntigqdsqsmylevqyapklqgpvavytwegn 421 qvnitcevfaypsatiswfrdgqllpssnysnikiyntpsasylevtpdsendfgnynct 481 avnrigqeslefilvqadtpsspsidqvepysstaqvqfdepeatggvpilkykaewrav 541 geevwhskwydakeasmegivtivglkpettyavrlaalngkglgeisaasefktqpvqg 601 epsapklegqmgedgnsikvnlikqddggspirhylvryralssewkpeirlpsgsdhvm 661 lksldwnaeyevyvvaenqqgkskaahfvfrtsaqptaipatlggnsasytfvsllfsav 721 tllllc Proteinsequenceisoform5(SEQIDNO(31)): 1 mlqtkdliwtlfflgtavslqvdivpsqgeisvgeskfflcqvagdakdkdiswfspnge 61 kltpnqqrisvvwnddssstltiynaniddagiykcvvtgedgseseatvnvkifqklmf 121 knaptpqefregedavivcdvvsslpptiiwkhkgrdvilkkdvrfivlsnnylqirgik 181 ktdegtyrcegrilargeinfkdiqvivnvpptiqarqnivnatanlgqsvtlvcdaegf 241 peptmswtkdgeqieqeeddekyifsddssqltikkvdkndeaeyiciaenkageqdati 301 hlkvfakpkityvenqtameleeqvtltceasgdpipsitwrtstrnisseekaswtrpe 361 kqevhapwnwqvgrqkgqagsagfpgshetldghmvvrsharvssltlksiqytdageyi 421 ctasntigqdsqsmylevqyapklqgpvavytwegnqvnitcevfaypsatiswfrdgql 481 lpssnysnikiyntpsasylevtpdsendfgnynctavnrigqeslefilvqadtpssps 541 idqvepysstaqvqfdepeatggvpilkykaewravgeevwhskwydakeasmegivtiv 601 glkpettyavrlaalngkglgeisaasefktqpvqgepsapklegqmgedgnsikvnlik 661 qddggspirhylvryralssewkpeirlpsgsdhvmlksldwnaeyevyvvaenqqgksk 721 aahfvfrtsaqptaipangsptsglstgaivgilivifvlllvvvditcyflnkcglfmc 781 iavnlcgkagpgakgkdmeegkaafskdeskepivevrteeertpnhdggkhtepnettp 841 ltepekgpveakpecqetetkpapaevktvpndatqtkeneska GeneID: X16 Genesymbol: NRP2 Genedescription: Neuropilin-2 Unigene: Hs.471200 Genbank: BX537423|AF016098|BC101525|BC104770|BC117413|BC143238|BC143608| AF022860|AF280545|AF280544|AF022859|AK290934|AF280546|BC009222| AL833606|BX648292|AK130198|BC018631 EntrezGene: 8828 Refseq: NM_201266|NM_003872|NM_201279|NM_018534|NM_201267|NM_201264 Proteinsequenceisoform1(SEQIDNO(32)): 1 mdmfpltwvflalyfsrhqvrgqpdppcggrlnskdagyitspgypqdypshqncewivy 61 apepnqkivlnfnphfeiekhdckydfieirdgdsesadllgkhcgniapptiissgsml 121 yikftsdyarqgagfslryeifktgsedcsknftspngtiespgfpekyphnldctftil 181 akpkmeiilqflifdlehdplqvgegdckydwldiwdgiphvgpligkycgtktpselrs 241 stgilsltfhtdmavakdgfsaryylvhqeplenfqcnvplgmesgrianeqisasstys 301 dgrwtpqqsrlhgddngwtpnldsnkeylqvdlrfltmltaiatqgaisretqngyyvks 361 yklevstngedwmvyrhgknhkvfqanndatevvlnklhaplltrfvrirpqtwhsgial 421 rlelfgcrvtdapcsnmlgmlsgliadsqisasstqeylwspsaarlvssrsgwfpripq 481 aqpgeewlqvdlgtpktvkgviiqgarggdsitavearafvrkfkvsyslngkdweyiqd 541 prtqqpklfegnmhydtpdirrfdpipaqyvrvyperwspagigmrlevlgcdwtdskpt 601 vetlgptvkseetttpypteeeatecgencsfeddkdlqlpsgfncnfdfleepcgwmyd 661 hakwlrttwasssspndrtfpddrnflrlqsdsqregqyarlisppvhlprspvcmefqy 721 qatggrgvalqvvreasqeskllwviredqggewkhgriilpsydmeyqivfegvigkgr 781 sgeiaiddiristdvplencmepisafagenfkvdipeiheregyedeiddeyevdwsns 841 ssatsgsgapstdkekswlytldpilitiiamsslgvllgatcaglllyctcsysglssr 901 scttlenynfelydglkhkvkmnhqkccsea Proteinsequenceisoform2(SEQIDNO(33)): 1 mdmfpltwvflalyfsrhqvrgqpdppcggrlnskdagyitspgypqdypshqncewivy 61 apepnqkivlnfnphfeiekhdckydfieirdgdsesadllgkhcgniapptiissgsml 121 yikftsdyarqgagfslryeifktgsedcsknftspngtiespgfpekyphnldctftil 181 akpkmeiilqflifdlehdplqvgegdckydwldiwdgiphvgpligkycgtktpselrs 241 stgilsltfhtdmavakdgfsaryylvhqeplenfqcnvplgmesgrianeqisasstys 301 dgrwtpqqsrlhgddngwtpnldsnkeylqvdlrfltmltaiatqgaisretqngyyvks 361 yklevstngedwmvyrhgknhkvfqanndatevvlnklhaplltrfvrirpqtwhsgial 421 rlelfgcrvtdapcsnmlgmlsgliadsqisasstqeylwspsaarlvssrsgwfpripq 481 aqpgeewlqvdlgtpktvkgviiqgarggdsitavearafvrkfkvsyslngkdweyiqd 541 prtqqpklfegnmhydtpdirrfdpipaqyvrvyperwspagigmrlevlgcdwtdskpt 601 vetlgptvkseetttpypteeeatecgencsfeddkdlqlpsgfncnfdfleepcgwmyd 661 hakwlrttwasssspndrtfpddrnflrlqsdsqregqyarlisppvhlprspvcmefqy 721 qatggrgvalqvvreasqeskllwviredqggewkhgriilpsydmeyqivfegvigkgr 781 sgeiaiddiristdvplencmepisafavdipeiheregyedeiddeyevdwsnsssats 841 gsgapstdkekswlytldpilitiiamsslgvllgatcaglllyctcsysglssrscttl 901 enynfelydglkhkvkmnhqkccsea Proteinsequenceisoform3(SEQIDNO(34)): 1 mdmfpltwvflalyfsrhqvrgqpdppcggrlnskdagyitspgypqdypshqncewivy 61 apepnqkivlnfnphfeiekhdckydfieirdgdsesadllgkhcgniapptiissgsml 121 yikftsdyarqgagfslryeifktgsedcsknftspngtiespgfpekyphnldctftil 181 akpkmeiilqflifdlehdplqvgegdckydwldiwdgiphvgpligkycgtktpselrs 241 stgilsltfhtdmavakdgfsaryylvhqeplenfqcnvplgmesgrianeqisasstys 301 dgrwtpqqsrlhgddngwtpnldsnkeylqvdlrfltmltaiatqgaisretqngyyvks 361 yklevstngedwmvyrhgknhkvfqanndatevvlnklhaplltrfvrirpqtwhsgial 421 rlelfgcrvtdapcsnmlgmlsgliadsqisasstqeylwspsaarlvssrsgwfpripq 481 aqpgeewlqvdlgtpktvkgviiqgarggdsitavearafvrkfkvsyslngkdweyiqd 541 prtqqpklfegnmhydtpdirrfdpipaqyvrvyperwspagigmrlevlgcdwtdskpt 601 vetlgptvkseetttpypteeeatecgencsfeddkdlqlpsgfncnfdfleepcgwmyd 661 hakwlrttwasssspndrtfpddrnflrlqsdsqregqyarlisppvhlprspvcmefqy 721 qatggrgvalqvvreasqeskllwviredqggewkhgriilpsydmeyqivfegvigkgr 781 sgeiaiddiristdvplencmepisafadeyevdwsnsssatsgsgapstdkekswlytl 841 dpilitiiamsslgvllgatcaglllyctcsysglssrscttlenynfelydglkhkvkm 901 nhqkccsea Proteinsequenceisoform4(SEQIDNO(35)): 1 mdmfpltwvflalyfsrhqvrgqpdppcggrlnskdagyitspgypqdypshqncewivy 61 apepnqkivlnfnphfeiekhdckydfieirdgdsesadllgkhcgniapptiissgsml 121 yikftsdyarqgagfslryeifktgsedcsknftspngtiespgfpekyphnldctftil 181 akpkmeiilqflifdlehdplqvgegdckydwldiwdgiphvgpligkycgtktpselrs 241 stgilsltfhtdmavakdgfsaryylvhqeplenfqcnvplgmesgrianeqisasstys 301 dgrwtpqqsrlhgddngwtpnldsnkeylqvdlrfltmltaiatqgaisretqngyyvks 361 yklevstngedwmvyrhgknhkvfqanndatevvlnklhaplltrfvrirpqtwhsgial 421 rlelfgcrvtdapcsnmlgmlsgliadsqisasstqeylwspsaarlvssrsgwfpripq 481 aqpgeewlqvdlgtpktvkgviiqgarggdsitavearafvrkfkvsyslngkdweyiqd 541 prtqqpklfegnmhydtpdirrfdpipaqyvrvyperwspagigmrlevlgcdwtdskpt 601 vetlgptvkseetttpypteeeatecgencsfeddkdlqlpsgfncnfdfleepcgwmyd 661 hakwlrttwasssspndrtfpddrnflrlqsdsqregqyarlisppvhlprspvcmefqy 721 qatggrgvalqvvreasqeskllwviredqggewkhgriilpsydmeyqivfegvigkgr 781 sgeiaiddiristdvplencmepisafagenfkggtllpgteptvdtvpmqpipaywyyv 841 maaggavlvlvsvalalvlhyhrfryaakktdhsityktshytngaplaveptltikleq 901 drgshc Proteinsequenceisoform5(SEQIDNO(36)): 1 mdmfpltwvflalyfsrhqvrgqpdppcggrlnskdagyitspgypqdypshqncewivy 61 apepnqkivlnfnphfeiekhdckydfieirdgdsesadllgkhcgniapptiissgsml 121 yikftsdyarqgagfslryeifktgsedcsknftspngtiespgfpekyphnldctftil 181 akpkmeiilqflifdlehdplqvgegdckydwldiwdgiphvgpligkycgtktpselrs 241 stgilsltfhtdmavakdgfsaryylvhqeplenfqcnvplgmesgrianeqisasstys 301 dgrwtpqqsrlhgddngwtpnldsnkeylqvdlrfltmltaiatqgaisretqngyyvks 361 yklevstngedwmvyrhgknhkvfqanndatevvlnklhaplltrfvrirpqtwhsgial 421 rlelfgcrvtdapcsnmlgmlsgliadsqisasstqeylwspsaarlvssrsgwfpripq 481 aqpgeewlqvdlgtpktvkgviiqgarggdsitavearafvrkfkvsyslngkdweyiqd 541 prtqqpklfegnmhydtpdirrfdpipaqyvrvyperwspagigmrlevlgcdwtdskpt 601 vetlgptvkseetttpypteeeatecgencsfeddkdlqlpsgfncnfdfleepcgwmyd 661 hakwlrttwasssspndrtfpddrnflrlqsdsqregqyarlisppvhlprspvcmefqy 721 qatggrgvalqvvreasqeskllwviredqggewkhgriilpsydmeyqivfegvigkgr 781 sgeiaiddiristdvplencmepisafaggtllpgteptvdtvpmqpipaywyyvmaagg 841 avlvlvsvalalvlhyhrfryaakktdhsityktshytngaplaveptltikleqdrgsh 901 c Proteinsequenceisoform6(SEQIDNO(37)): 1 mdmfpltwvflalyfsrhqvrgqpdppcggrlnskdagyitspgypqdypshqncewivy 61 apepnqkivlnfnphfeiekhdckydfieirdgdsesadllgkhcgniapptiissgsml 121 yikftsdyarqgagfslryeifktgsedcsknftspngtiespgfpekyphnldctftil 181 akpkmeiilqflifdlehdplqvgegdckydwldiwdgiphvgpligkycgtktpselrs 241 stgilsltfhtdmavakdgfsaryylvhqeplenfqcnvplgmesgrianeqisasstys 301 dgrwtpqqsrlhgddngwtpnldsnkeylqvdlrfltmltaiatqgaisretqngyyvks 361 yklevstngedwmvyrhgknhkvfqanndatevvlnklhaplltrfvrirpqtwhsgial 421 rlelfgcrvtdapcsnmlgmlsgliadsqisasstqeylwspsaarlvssrsgwfpripq 481 aqpgeewlqvdlgtpktvkgviiqgarggdsitavearafvrkfkvsyslngkdweyiqd 541 prtqqpkvgcswrpl GeneID: X17 Genesymbol: PLXNA2 Genedescription: Plexin-A2 Unigene: Hs.497626 Genbank: BC132676 EntrezGene: 5362 Refseq: NM_025179 Proteinsequence(SEQIDNO(38)): 1 meqrrpwpralevdsrsvvllsvvwvllappaagmpqfstfhsenrdwtfnhltvhqgtg 61 avyvgainrvykltgnltiqvahktgpeednkscypplivqpcsevltltnnvnklliid 121 ysenrllacgslyqgvckllrlddlfilvepshkkehylssvnktgtmygvivrsegedg 181 klfigtavdgkqdyfptlssrklprdpessamldyelhsdfvsslikipsdtlalvshfd 241 ifyiygfasggfvyfltvqpetpegvainsagdlfytsrivrlckddpkfhsyvslpfgc 301 tragveyrllqaaylakpgdslaqafnitsqddvlfaifskgqkqyhhppddsalcafpi 361 rainlqikerlqscyqgegnlelnwllgkdvqctkapvpiddnfcgldinqplggstpve 421 gltlyttsrdrmtsvasyvyngysvvfvgtksgklkkiradgpphggvqyemvsvlkdgs 481 pilrdmafsidqrylyvmserqvtrvpvesceqyttcgeclssgdphcgwcalhnmcsrr 541 dkcqqawepnrfaasisqcvslavhpssisvsehsrllslvvsdapdlsagiacafgnlt 601 evegqvsgsqvicispgpkdvpvipldqdwfglelqlrsketgkifvstefkfyncsahq 661 lclscvnsafrchwckyrnlcthdpttcsfqegrinisedcpqlvpteeilipvgevkpi 721 tlkarnlpqpqsgqrgyecvlniqgaihrvpalrfnsssvqcqnssyqydgmdisnlavd 781 favvwngnfiidnpqdlkvhlykcaaqrescglclkadrkfecgwcsgerrctlhqhcts 841 psspwldwsshnvkcsnpqiteiltvsgppeggtrvtihgvnlgldfseiahhvqvagvp 901 ctplpgeyiiaeqivcemghalvgttsgpvrlcigeckpefmtkshqqytfvnpsvlsln 961 pirgpesggtmvtitghylgagssvavylgnqtcefygrsmseivcvsppssnglgpvpv 1021 svsvdrahvdsnlqfeyiddprvqriepewsiasghtpltitgfnldviqeprirvkfng 1081 kesvnvckvvntttltclapslttdyrpgldtverpdefgfvfnnvqslliyndtkfiyy 1141 pnptfellsptgvldqkpgspiilkgknlcppasggaklnytvligetpcavtvsetqll 1201 ceppnltgqhkvmvhvggmvfspgsvsvisdslltlpaivsiaaggsllliiviivliay 1261 krksrendltlkrlqmqmdnlesrvaleckeafaelqtdineltsdldrsgipyldyrty 1321 amrvlfpgiedhpvlrelevqgngqqhvekalklfaqlinnkvflltfirtlelqrsfsm 1381 rdrgnvaslimtglqgrleyatdvlkqllsdlidknlenknhpklllrrtesvaekmltn 1441 wfafllhkflkecageplfmlycaikqqmekgpidaitgearyslsedklirqqieyktl 1501 ilncvnpdnenspeipvkvlncdtitqvkekildavyknvpysqrpravdmdlewrqgri 1561 arvvlqdedittkiegdwkrlntlmhyqvsdrswvalvpkqtssynipasasisrtsisr 1621 ydssfrytgspdslrsrapmitpdlesgvkvwhlvknhdhgdqkegdrgskmvseiyltr 1681 llatkgtlqkfvddlfetlfstvhrgsalplaikymfdfldeqadrhsihdtdvrhtwks 1741 nclplrfwvnviknpqfvfdihkgsitdaclsvvaqtfmdscstsehrlgkdspsnklly 1801 akdipsykswveryyadiaklpaisdqdmnaylaeqsrlhavefnmlsalneiysyvsky 1861 seeligaleqdeqarrqrlaykveqlinamsies GeneID: X18 Genesymbol: PCDHA4 Genedescription: Protocadherinalpha-4 Unigene: Hs.199343 Genbank: AF152482|AF152312 EntrezGene: 56144 Refseq: NM_018907|NM_031500 Proteinsequenceisoform1(SEQIDNO(39)): 1 mefswgsgqesrrllllllllaaweagngqlhysvseeakhgtfvgriaqdlglelaelv 61 prlfrvaskgrggllevnlqngilfvnsridreelcrrsaecsihlevivdrplqvfhvd 121 vevrdindnppvfpatqknlsiaesrpldsrfplegasdadigenalltyrlspneyfsl 181 ekppddelvkglglilrksldreeapeiflvltatdggkpeltgtvqllitvldandnap 241 afdrtiykvrllenvpngtlviklnasdldeglngdivysfsndispnvkskfhidpitg 301 qiivkgyidfeesksyeiivegidkgqlplsghcrvivevednndnvpdlefkslslpir 361 edaplgtvialisvsdkdmgvnglvtcsltshvpfklvstfknyyslvldsaldresvsa 421 yelvvtardggspslwatasvsvevadvndnapafaqpeytvfvkennppgchiftvsaw 481 dadaqenalvsyslverrvgeralssyvsvhaesgkvyalqpldheelellqfqvtarda 541 gvpplgsnvtlqvfvldendnapallapraggtggavselvpwsvgvghvvakvravdad 601 sgynawlsyelqpgtggaripfrvglytgeisttraldetdaprhrllvlvkdhgepalt 661 atatvlvslvesgqapkassralvgavgpdaalvdvnvyliiaicavssllvltlllyta 721 lrcsalptegacapgkptlvcssavgswsysqqrrprvcsgegppktdlmafspslpdsr 781 dredqlqtteesfakprqpnpdwrysaslragmhssvhleeagilragpggpdqqwptvs 841 satpepeagevsppvgagvnsnswtfkygpgnpkqsgpgelpdkfiipgspaiisirqep 901 tnsqidksdfitfgkkeetkkkkkkkkgnktqekkekgnsttdnsdq Proteinsequenceisoform2(SEQIDNO(40)): 1 mefswgsgqesrrllllllllaaweagngqlhysvseeakhgtfvgriaqdlglelaelv 61 prlfrvaskgrggllevnlqngilfvnsridreelcrrsaecsihlevivdrplqvfhvd 121 vevrdindnppvfpatqknlsiaesrpldsrfplegasdadigenalltyrlspneyfsl 181 ekppddelvkglglilrksldreeapeiflvltatdggkpeltgtvqllitvldandnap 241 afdrtiykvrllenvpngtlviklnasdldeglngdivysfsndispnvkskfhidpitg 301 qiivkgyidfeesksyeiivegidkgqlplsghcrvivevednndnvpdlefkslslpir 361 edaplgtvialisvsdkdmgvnglvtcsltshvpfklvstfknyyslvldsaldresvsa 421 yelvvtardggspslwatasvsvevadvndnapafaqpeytvfvkennppgchiftvsaw 481 dadaqenalvsyslverrvgeralssyvsvhaesgkvyalqpldheelellqfqvtarda 541 gvpplgsnvtlqvfvldendnapallapraggtggavselvpwsvgvghvvakvravdad 601 sgynawlsyelqpgtggaripfrvglytgeisttraldetdaprhrllvlvkdhgepalt 661 atatvlvslvesgqapkassralvgavgpdaalvdvnvyliiaicavssllvltlllyta 721 lrcsalptegacapgkptlvcssavgswsysqqrrprvcsgegppktdlmafspslpdsr 781 dredqlqtteesfakvsv GeneID: X19 Genesymbol: PCDHAC2 Genedescription: Protocadherinalpha-C2 Unigene: Hs.199343 Genbank: AF152304 EntrezGene: 56134 Refseq: NM_018899|NM_031883 Proteinsequenceisoform1(SEQIDNO(41)): 1 meqagtrpaatehprlrrpmpwllllplllllllllpgpaasqlrysvpeeqapgalvgn 61 varalglelrrlgpgclrinhlgapspryleldltsgalfvneridrealceqrprclls 121 levlahnpvavsaveveildindnsprfprpnyqlqvsesvapgarfhiesaqdpdvgan 181 svqtyelspsehfeldlkplqenskvlelvlrkgldreqaalhhlvltavdggiparsgt 241 aqisvrvldtndnspafdqstyrvqlredsppgtlvvklnasdpdegsngelryslssyt 301 sdrerqlfsidastgevrviggldyeeassyqiyvqatdrgpvpmaghckvlvdivdvnd 361 napevvltdlyspvpenatpntivavlsvndqdsgpnrkvslgleatlpfrlngfgnsyt 421 lvvsgpldrervavynitvtatdggipqltslrtlkveisdindnppsfledsysiyiqe 481 nnlpgvllctvqatdpdekenaevtysllereiqglpvtsyvsinsasgslyavnsfdye 541 kfreffvtveaqdkgspplsstvtanvyvvdmndhaphilyptstnssaafemvprtapa 601 gylvtkviamdsdsgqnawlfyhlaqtsdldlfkvelhtgeirttrkmgdesgstfnltv 661 vvrdngepslsasvaitvavvdrvskilpdtqrhvksprtyseitlyliialstvsfifl 721 ltiiilsiikcyrytaygtaccggfcgvrerspaelykqannnidariphglkvqphfie 781 vrgngsltktycykacltagsgsdtfmfyntgaqtgpgpsgaqaavtdsrnltgqsgqna 841 gnliilkneavsqneprqpnpdwrysaslragmhssvhleeagilragpggpdqqwptvs 901 satpepeagevsppvgagvnsnswtfkygpgnpkqsgpgelpdkfiipgspaiisirqep 961 tnsqidksdfitfgkkeetkkkkkkkkgnktqekkekgnsttdnsdq Proteinsequenceisoform2(SEQIDNO(42)): 1 meqagtrpaatehprlrrpmpwllllplllllllllpgpaasqlrysvpeeqapgalvgn 61 varalglelrrlgpgclrinhlgapspryleldltsgalfvneridrealceqrprclls 121 levlahnpvavsaveveildindnsprfprpnyqlqvsesvapgarfhiesaqdpdvgan 181 svqtyelspsehfeldlkplqenskvlelvlrkgldreqaalhhlvltavdggiparsgt 241 aqisvrvldtndnspafdqstyrvqlredsppgtlvvklnasdpdegsngelryslssyt 301 sdrerqlfsidastgevrviggldyeeassyqiyvqatdrgpvpmaghckvlvdivdvnd 361 napevvltdlyspvpenatpntivavlsvndqdsgpnrkvslgleatlpfrlngfgnsyt 421 lvvsgpldrervavynitvtatdggipqltslrtlkveisdindnppsfledsysiyiqe 481 nnlpgvllctvqatdpdekenaevtysllereiqglpvtsyvsinsasgslyavnsfdye 541 kfreffvtveaqdkgspplsstvtanvyvvdmndhaphilyptstnssaafemvprtapa 601 gylvtkviamdsdsgqnawlfyhlaqtsdldlfkvelhtgeirttrkmgdesgstfnltv 661 vvrdngepslsasvaitvavvdrvskilpdtqrhvksprtyseitlyliialstvsfifl 721 ltiiilsiikcyrytaygtaccggfcgvrerspaelykqannnidariphglkvqphfie 781 vrgngsltktycykacltagsgsdtfmfyntgaqtgpgpsgaqaavtdsrnltgqsgqna 841 gnliilkneavsqnevrqwsggllqthafvthppiscdlallsh GeneID: X20 Genesymbol: GPC4 Genedescription: Glypican4 Unigene: Hs.58367 Genbank: AF030186 EntrezGene: 2239 Refseq: NM_001448 Proteinsequence(SEQIDNO(43)): 1 mrllwklvillplinssagdgllsrpiftqephdvifpldlsksevilncaangypsphy 61 rwkqngtdidftmsyhyrldggslainsphtdqdigmyqclatnllgtilsrkaklqfay 121 iedfetktrstvsvregqgvvllcgppphfgdlsyawtfndnplyvqednrrfvsqetgn 181 lyiakvepsdvgnytcfitnkeaqrsvqgpptplvqrtdgvmgeyepkievrfpetiqaa 241 kdssvklecfalgnpvpdiswrrldgsplpgkvkysksqaileipnfqqedegfyecias 301 nlrgrnlakgqlifyappeweqkiqnthlsiydnllweckasgkpnpwytwlkngerlnp 361 eeriqiengtliitmlnvsdsgvyqcaaenkyqiiyanaelrvlasapdfskspvkkksf 421 vqvggdivigckpnafpraaiswkrgtetlrqskriflledgslkiynitrsdagsytci 481 atnqfgtakntgslivkertvitvppskmdvtvgesivlpcqvshdpsievvfvwffngd 541 vidlkkgvahferiggesvgdlmirniqlhhsgkylctvqttleslsavadiivrgppgp 601 pedvqvedissttsqlswragpdnnspiqiftiqtrtpfsvgwqavatvpeilngktyna 661 tvvglspwveyefrvvagnsigigepsepsellrtkasvpvvapvnihggggsrselvit 721 wesipeelqngegfgyiimfrpvgsttwskekvssvessrfvyrnesiiplspfevkvgv 781 ynnegegslstvtivysgedepqlaprgtslqsfsasemevswnaiawnrntgrvlgyev 841 lywtddskesmigkirvsgnvttknitglkantiyfasvrayntagtgpssppvnvttkk 901 sppsqppaniawkltnsklclnwehvktmenesevlgykilyrqnrqskthiletnntsa 961 ellvpfeedylieirtvsdggdgssseeiripkmsslssrgiqflepsthflsivivifh 1021 cfaiqpli GeneID: X21 Genesymbol: CNTN6 Genedescription: Contactin6 Unigene: Hs.387300 Genbank: AB003592 EntrezGene: 27255 Refseq: NM_014461 Proteinsequence(SEQIDNO(44)): 1 marfglpallctlavlsaallaaelkskscsevrrlyvskgfnkndaplheingdhlkic 61 pqgstccsqemeekyslqskddfksvvseqcnhlqavfasrykkfdeffkellenaeksl 121 ndmfvktyghlymqnselfkdlfvelkryyvvgnvnleemlndfwarllermfrivnsqy 181 hftdeylecvskyteqlkpfgdvprklklqvtrafvaartfaqglavagdvvskvsvvnp 241 taqcthallkmiycshcrglvtvkpcynycsnimrgclanqgdldfewnnfidamlmvae 301 rlegpfniesvmdpidvkisdaimnmqdnsvqvsqkvfqgcgppkplpagrisrsisesa 361 fsarfrphhpeerpttaagtsldrlvtdvkeklkqakkfwsslpsnvcndermaagngne 421 ddcwngkgksrylfavtgnglanqgnnpevqvdtskpdililrqimalrvmtskmknayn 481 gndvdffdisdessgegsgsgceyqqcpsefdynatdhagksanekadsagvrpgaqayl 541 ltvfcilflvmqrewr GeneID: X22 Genesymbol: SLC9A7 Genedescription: solutecarrierfamily9(sodium/hydrogenexchanger),member7 Unigene: Hs.496057 Genbank: AF298591 EntrezGene: 84679 Refseq: NM_001257291|NM_032591 Proteinsequenceisoform1(SEQIDNO(45)): 1 mepgdaarpgsgratgappprllllplllgwglrvaaaasasssgaaaedssameelate 61 keaeeshrqdsvslltfillltltiltiwlfkhrrvrflhetglamiyglivgvilrygt 121 patsgrdkslsctqedrafstllvnvsgkffeytlkgeispgkinsveqndmlrkvtfdp 181 evffnillppiifhagyslkkrhffrnlgsilayaflgtavscfiignlmygvvklmkim 241 gqlsdkfyytdclffgaiisatdpvtvlaifnelhadvdlyallfgesvlndavaivlss 301 sivayqpaglnthafdaaaffksvgiflgifsgsftmgavtgvvtalvtkftklhcfpll 361 etalfflmswstfllaeacgftgvvavlfcgitqahytynnlsvesrsrtkqlfevlhfl 421 aenfifsymglalftfqkhvfspifiigafvaiflgraahiyplsfflnlgrrhkigwnf 481 qhmmmfsglrgamafalairdtasyarqmmftttllivfftvwiigggttpmlswlnirv 541 gveepseedqnehhwqyfrvgvdpdqdpppnndsfqvlqgdgpdsargnrtkqesawifr 601 lwysfdhnylkpilthsgppltttlpawcgllarcltspqvydnqeplreedsdfilteg 661 dltltygdstvtangsssshtastslegsrrtkssseevlerdlgmgdqkvssrgtrlvf 721 pledna Proteinsequenceisoform2(SEQIDNO(46)): 1 mepgdaarpgsgratgappprllllplllgwglrvaaaasasssgaaaedssameelate 61 keaeeshrqdsvslltfillltltiltiwlfkhrrvrflhetglamiyglivgvilrygt 121 patsgrdkslsctqedrafstllvnvsgkffeytlkgeispgkinsveqndmlrkvtfdp 181 evffnillppiifhagyslkkrhffrnlgsilayaflgtavscfiignlmygvvklmkim 241 gqlsdkfyytdclffgaiisatdpvtvlaifnelhadvdlyallfgesvlndavaivlss 301 sivayqpaglnthafdaaaffksvgiflgifsgsftmgavtgvnanvtkftklhcfplle 361 talfflmswstfllaeacgftgvvavlfcgitqahytynnlsvesrsrtkqlfevlhfla 421 enfifsymglalftfqkhvfspifiigafvaiflgraahiyplsfflnlgrrhkigwnfq 481 hmmmfsglrgamafalairdtasyarqmmftttllivfftvwiigggttpmlswlnirvg 541 veepseedqnehhwqyfrvgvdpdqdpppnndsfqvlqgdgpdsargnrtkqesawifrl 601 wysfdhnylkpilthsgppltttlpawcgllarcltspqvydnqeplreedsdfiltegd 661 ltltygdstvtangsssshtastslegsrrtkssseevlerdlgmgdqkvssrgtrlvfp 721 ledna GeneID: X23 Genesymbol: PVRL3 Genedescription: poliovirusreceptor-related3 Unigene: Hs.293917 Genbank: AK075105 EntrezGene: 25945 Refseq: NM_015480|NM_001243286|NM_001243288 Proteinsequenceisoform1(SEQIDNO(47)): 1 martlrpsplcpgggkaqlssasllgaglllqpptppplllllfplllfsrlcgalagpi 61 ivephvtavwgknvslkclievnetitqiswekihgkssqtvavhhpqygfsvqgeyqgr 121 vlfknyslndatitlhnigfsdsgkyickavtfplgnaqssttvtvlveptvslikgpds 181 lidggnetvaaiciaatgkpvahidwegdlgemestttsfpnetatiisqyklfptrfar 241 grritcvvkhpalekdirysfildiqyapevsvtgydgnwfvgrkgvnlkcnadanpppf 301 ksvwsrldgqwpdgllasdntlhfvhpltfnysgvyickvtnslgqrsdqkviyisdppt 361 tttlqptiqwhpstadiedlatepkklpfplstlatikddtiatiiasvvggalfivlvs 421 vlagifcyrrrrtfrgdyfaknyippsdmqkesqidvlqqdeldsypdsvkkenknpvnn 481 lirkdyleepektqwnnvenlnrferpmdyyedlkmgmkfvsdehydeneddlvshvdgs 541 visrrewyv Proteinsequenceisoform2(SEQIDNO(48)): 1 martlrpsplcpgggkaqlssasllgaglllqpptppplllllfplllfsrlcgalagpi 61 ivephvtavwgknvslkclievnetitqiswekihgkssqtvavhhpqygfsvqgeyqgr 121 vlfknyslndatitlhnigfsdsgkyickavtfplgnaqssttvtvlveptvslikgpds 181 lidggnetvaaiciaatgkpvahidwegdlgemestttsfpnetatiisqyklfptrfar 241 grritcvvkhpalekdirysfildiqyapevsvtgydgnwfvgrkgvnlkcnadanpppf 301 ksvwsrldgqwpdgllasdntlhfvhpltfnysgvyickvtnslgqrsdqkviyisayns 361 vaslnc Proteinsequenceisoform3(SEQIDNO(49)): 1 maegwrwcfvrrtpgllrgpllprsfsgnpralagpiivephvtavwgknvslkclievn 61 etitqiswekihgkssqtvavhhpqygfsvqgeyqgrvlfknyslndatitlhnigfsds 121 gkyickavtfplgnaqssttvtvlveptvslikgpdslidggnetvaaiciaatgkpvah 181 idwegdlgemestttsfpnetatiisqyklfptrfargrritcvvkhpalekdirysfil 241 diqyapevsvtgydgnwfvgrkgvnlkcnadanpppfksvwsrldgqwpdgllasdntlh 301 fvhpltfnysgvyickvtnslgqrsdqkviyisdvpfkqtssiavagavigavlalfiia 361 ifvtvlltprkkrpsyldkvidlppthkppplyeerspplpqkdlfqpehlplqtqfker 421 evgnlqhsnglnsrsfdyedenpvgedgiqqmyplynqmcyqdrspgkhhqnndpkrvyi 481 dprehyv GeneID: X24 Genesymbol: SLC4A4 Genedescription: solutecarrierfamily4,sodiumbicarbonatecotransporter,member4 Unigene: Hs.5462 Genbank: AF011390 EntrezGene: 8671 Refseq: NM_001098484|NM_001134742|NM_003759 Proteinsequenceisoform1(SEQIDNO(50)): 1 medeavldrgasflkhvcdeeeveghhtiyigvhvpksyrrrrrhkrktghkekkekeri 61 senysdksdienadessssilkplispaaerirfilgeeddspappqlfteldellavdg 121 qemewketarwikfeekveqggerwskphvatlslhslfelrtcmekgsimldreasslp 181 qlvemivdhqietgllkpelkdkvtytllrkhrhqtkksnlrsladigktvssasrmftn 241 pdngspamthrnltssslndisdkpekdqlknkfmkklprdaeasnvlvgevdfldtpfi 301 afvrlqqavmlgaltevpvptrflfillgpkgkaksyheigraiatlmsdevfhdiayka 361 kdrhdliagidefldevivlppgewdpairieppkslpssdkrknmysggenvqmngdtp 421 hdgghgggghgdceelqrtgrfcgglikdikrkapffasdfydalniqalsailfiylat 481 vtnaitfggllgdatdnmqgvlesflgtavsgaifclfagqpltilsstgpvlvferllf 541 nfskdnnfdylefrlwiglwsaflclilvatdasflvqyftrfteegfsslisfifiyda 601 fkkmikladyypinsnfkvgyntlfsctcvppdpanisisndttlapeylptmsstdmyh 661 nttfdwaflskkecskyggnlvgnncnfvpditlmsfilflgtytssmalkkfktspyfp 721 ttarklisdfaiilsilifcvidalvgvdtpklivpsefkptspnrgwfvppfgenpwwv 781 claaaipallvtilifmdqqitavivnrkehklkkgagyhldlfwvailmvicslmalpw 841 yvaatvisiahidslkmetetsapgeqpkflgvreqrvtgtlvfiltglsvfmapilkfi 901 pmpvlygvflymgvasingvqfmdrlklllmplkhqpdfiylrhvplrrvhlftflqvlc 961 lallwilkstvaaiifpvmilalvavrkgmdylfsqhdlsflddvipekdkkkkedekkk 1021 kkkkgsldsdnddsdcpysekvpsikipmdimeqqpflsdskpsdrersptflerhtsc Proteinsequenceisoform3(SEQIDNO(51)): 1 medeavldrgasflkhvcdeeeveghhtiyigvhvpksyrrrrrhkrktghkekkekeri 61 senysdksdienadessssilkplispaaerirfilgeeddspappqlfteldellavdg 121 qemewketarwikfeekveqggerwskphvatlslhslfelrtcmekgsimldreasslp 181 qlvemivdhqietgllkpelkdkvtytllrkhrhqtkksnlrsladigktvssasrmftn 241 pdngspamthrnltssslndisdkpekdqlknkfmkklprdaeasnvlvgevdfldtpfi 301 afvrlqqavmlgaltevpvptrflfillgpkgkaksyheigraiatlmsdevfhdiayka 361 kdrhdliagidefldevivlppgewdpairieppkslpssdkrknmysggenvqmngdtp 421 hdgghgggghgdceelqrtgrfcgglikdikrkapffasdfydalniqalsailfiylat 481 vtnaitfggllgdatdnmqgvlesflgtavsgaifclfagqpltilsstgpvlvferllf 541 nfskdnnfdylefrlwiglwsaflclilvatdasflvqyftrfteegfsslisfifiyda 601 fkkmikladyypinsnfkvgyntlfsctcvppdpanisisndttlapeylptmsstdmyh 661 nttfdwaflskkecskyggnlvgnncnfvpditlmsfilflgtytssmalkkfktspyfp 721 ttarklisdfaiilsilifcvidalvgvdtpklivpsefkptspnrgwfvppfgenpwwv 781 claaaipallvtilifmdqqitavivnrkehklkkgagyhldlfwvailmvicslmalpw 841 yvaatvisiahidslkmetetsapgeqpkflgvreqrvtgtlvfiltglsvfmapilkfi 901 pmpvlygvflymgvaslngvqfmdrlklllmplkhqpdfiylrhvplrrvhlftflqvlc 961 lallwilkstvaaiifpvmilalvavrkgmdylfsqhdlsflddvipekdkkkkedekkk 1021 kkkkgsldsdnddekdhqhslnathhadkipflqslgmpspprtpvkvvpqirieleped 1081 ndyfwrskgtettl Proteinsequenceisoform2(SEQIDNO(52)): 1 mstenvegkpsnlgergrarsstflrvvqpmfnhsiftsavspaaerirfilgeeddspa 61 ppqlfteldellavdgqemewketarwikfeekveqggerwskphvatlslhslfelrtc 121 mekgsimldreasslpqlvemivdhqietgllkpelkdkvtytllrkhrhqtkksnlrsl 181 adigktvssasrmftnpdngspamthrnltssslndisdkpekdqlknkfmkklprdaea 241 snvlvgevdfldtpfiafvrlqqavmlgaltevpvptrflfillgpkgkaksyheigrai 301 atlmsdevfhdiaykakdrhdliagidefldevivlppgewdpairieppkslpssdkrk 361 nmysggenvqmngdtphdgghgggghgdceelqrtgrfcgglikdikrkapffasdfyda 421 lniqalsailfiylatvtnaitfggllgdatdnmqgvlesflgtavsgaifclfagqplt 481 ilsstgpvlvferllfnfskdnnfdylefrlwiglwsaflclilvatdasflvqyftrft 541 eegfsslisfifiydafkkmikladyypinsnfkvgyntlfsctcvppdpanisisndtt 601 lapeylptmsstdmyhnttfdwaflskkecskyggnlvgnncnfvpditlmsfilflgty 661 tssmalkkfktspyfpttarklisdfaiilsilifcvidalvgvdtpklivpsefkptsp 721 nrgwfvppfgenpwwvclaaaipallvtilifmdqqitavivnrkehklkkgagyhldlf 781 wvailmvicslmalpwyvaatvisiahidslkmetetsapgeqpkflgvreqrvtgtlvf 841 iltglsvfmapilkfipmpvlygvflymgvaslngvqfmdrlklllmplkhqpdfiylrh 901 vplrrvhlftflqvlclallwilkstvaaiifpvmilalvavrkgmdylfsqhdlsfldd 961 vipekdkkkkedekkkkkkkgsldsdnddsdcpysekvpsikipmdimeqqpflsdskps 1021 drersptflerhtsc GeneID: X25 Genesymbol: CXADR Genedescription: coxsackievirusandadenovirusreceptor Unigene: Hs.634837 Genbank: AY072912|AY072911|AY072910|AK313526| EntrezGene: 1525 Refseq: NM_001338|NM_001207063|NM_001207064|NM_001207065| NM_001207066 Proteinsequenceisoform1(SEQIDNO(53)): 1 malllcfvllcgvvdfarslsittpeemiekakgetaylpckftlspedqgpldiewlis 61 padnqkvdqviilysgdkiyddyypdlkgrvhftsndlksgdasinvtnlqlsdigtyqc 121 kvkkapgvankkihlvvlvkpsgarcyvdgseeigsdfkikcepkegslplqyewqklsd 181 sqkmptswlaemtssvisvknasseysgtysctvrnrvgsdqcllrlnvvppsnkaglia 241 gaiigtllalaligliifccrkkrreekyekevhhdiredvpppksrtstarsyigsnhs 301 slgsmspsnmegysktqynqvpsedfertpqsptlppakvaapnlsrmgaipvmipaqsk 361 dgsiv Proteinsequenceisoform2(SEQIDNO(54)): 1 malllcfvllcgvvdfarslsittpeemiekakgetaylpckftlspedqgpldiewlis 61 padnqkvdqviilysgdkiyddyypdlkgrvhftsndlksgdasinvtnlqlsdigtyqc 121 kvkkapgvankkihlvvlvkpsgarcyvdgseeigsdfkikcepkegslplqyewqklsd 181 sqkmptswlagkmchlqravrplpeatsaviihpwgpcllptwkdiprlsitkyqvktln 241 allrvrlshllr Proteinsequenceisoform3(SEQIDNO(55)): 1 malllcfvllcgvvdfarslsittpeemiekakgetaylpckftlspedqgpldiewlis 61 padnqkvdqviilysgdkiyddyypdlkgrvhftsndlksgdasinvtnlqlsdigtyqc 121 kvkkapgvankkihlvvlgkmchlqravrplpeatsaviihpwgpcllptwkdiprlsit 181 kyqvktlnallrvrlshllr Proteinsequenceisoform4(SEQIDNO(56)): 1 malllcfvllcgvvdfarslsittpeemiekakgetaylpckftlspedqgpldiewlis 61 padnqkvdqvgrcatskepyvhcqklhrq Proteinsequenceisoform5(SEQIDNO(57)): 1 malllcfvllcgvvdfarslsittpeemiekakgetaylpckftlspedqgpldiewlis 61 padnqkvdqviilysgdkiyddyypdlkgrvhftsndlksgdasinvtnlqlsdigtyqc 121 kvkkapgvankkihlvvlvkpsgarcyvdgseeigsdfkikcepkegslplqyewqklsd 181 sqkmptswlaemtssvisvknasseysgtysctvrnrvgsdqcllrlnvvppsnkaglia 241 gaiigtllalaligliifccrkkrreekyekevhhdiredvpppksrtstarsyigsnhs 301 slgsmspsnmegysktqynqvpsedfertpqsptlppakfkypyktdgitvv GeneID: X26 Genesymbol: CADM4 Genedescription: celladhesionmolecule4 Unigene: Hs.370984 Genbank: AF363368 EntrezGene: 199731 Refseq: NM_145296 Proteinsequence(SEQIDNO(58)): 1 mgrarrfqwpllllwaaaagpgagqevqtenvtvaeggvaeitcrlhqydgsivviqnpa 61 rqtlffngtralkderfqleefsprrvrirlsdarledeggyfcqlytedthhqiatltv 121 lvapenpvvevreqaveggevelsclvprsrpaatlrwyrdrkelkgvsssqengkvwsv 181 astvrfrvdrkddggiiiceaqnqalpsghskqtqyvldvqysptarihasqavvregdt 241 lvltcavtgnprpnqirwnrgneslperaeavgetltlpglvsadngtytceasnkhgha 301 ralyvlvvydpgavveaqtsvpyaivggilallvfliicvlvgmvwcsvrqkgsylthea 361 sgldeqgeareaflngsdghkrkeeffi GeneID: Y1 Genesymbol: CLCA2 Genedescription: chloridechannelaccessory2 Unigene: Hs.241551 Genbank: BC041096 EntrezGene: 9635 Refseq: NM_006536 Proteinsequence(SEQIDNO(59)): 1 mtqrsiagpicnlkfvtllvalsselpflgagvqlqdngynglliainpqvpenqnlisn 61 ikemiteasfylfnatkrrvffrnikilipatwkannnskikqesyekanvivtdwygah 121 gddpytlqyrgcgkegkyihftpnfllndnltagygsrgrvfvhewahlrwgvfdeynnd 181 kpfyingqnqikvtressditgifvcekgpcpqenciisklfkegctfiynstqnatasi 241 mfmqslssvvefcnasthnqeapnlqnqmcslrsawdvitdsadfhhsfpmngtelpppp 301 tfslvqagdkwvclvldvsskmaeadrllqlqqaaefylmqiveihtfvgiasfdskgei 361 raqlhqinsnddrkllvsylpttvsaktdisicsglkkgfevveklngkaygsvmilvts 421 gddkllgnclptvlssgstihsialgssaapnleelsrltgglkffvpdisnsnsmidaf 481 srissgtgdifqqhiqlestgenvkphhqlkntvtvdntvgndtmflvtwqasgppeiil 541 fdpdgrkyytnnfitnltfrtaslwipgtakpghwtytlnnthhslqalkvtvtsrasns 601 avppatveafverdslhfphpvmiyanvkqgfypilnatvtatvepetgdpvtlrllddg 661 agadvikndgiysryffsfaangryslkvhvnhspsistpahsipgshamyvpgytangn 721 iqmnaprksvgrneeerkwgfsrvssggsfsvlgvpagphpdvfppckiidleavkveee 781 ltlswtapgedfdqgqatsyeirmskslqniqddfnnailvntskrnpqqagireiftfs 841 pqistngpehqpngetheshriyvairamdrnslqsavsniaqaplfippnsdpvpardy 901 lilkgvltamgligiicliivvthhtlsrkkradkkengtkll GeneID: Y2 Genesymbol: ECM1 Genedescription: extracellularmatrixprotein1 Unigene: Hs.81071 Genbank: U68187|U68186|AK097046 EntrezGene: 1893 Refseq: NM_004425|NM_022664|NM_001202858 Proteinsequenceisoform1(SEQIDNO(60)): 1 mgttaraalvltylavasaaseggftatgqrqlrpehfqevgyaappspplsrslpmdhp 61 dssqhgppfegqsqvqpppsqeatplqqekllpaqlpaekevgpplpqeavplqkelpsl 121 qhpneqkegtpapfgdqshpepeswnaaqhcqqdrsqggwghrldgfppgrpspdnlnqi 181 clpnrqhvvygpwnlpqssyshltrqgetlnfleigysrcchershtnrlecaklvweea 241 msrfceaefsvktrphwcctrqgearfscfqeeapqphyqlracpshqpdissglelpfp 301 pgvptldniknichlrrfrsvprnlpatdplqrellaliqlerefqrcerqgnnhtctwk 361 awedtldkycdreyavkthhhlccrhppsptrdecfarrapypnydrdiltidigrvtpn 421 lmghlcgnqrvltkhkhipglihnmtarccdlpfpeqaccaeeekltfindlcgprrniw 481 rdpalccylspgdeqvncfninylrnvalvsgdtenakgqgeqgstggtnisstsepkee Proteinsequenceisoform2(SEQIDNO(61)): 1 mgttaraalvltylavasaaseggftatgqrqlrpehfqevgyaappspplsrslpmdhp 61 dssqhgppfegqsqvqpppsqeatplqqekllpaqlpaekevgpplpqeavplqkelpsl 121 qhpneqkegtpapfgdqshpepeswnaaqhcqqdrsqggwghrldgfppgrpspdnlnqi 181 clpnrqhvvygpwnlpqssyshltrqgetlnfleigysrechershtnrlecaklvwedt 241 ldkycdreyavkthhhlccrhppsptrdecfarrapypnydrdiltidigrvtpnlmghl 301 cgnqrvltkhkhipglihnmtarccdlpfpeqaccaeeekltfindlcgprrniwrdpal 361 ccylspgdeqvncfninylrnvalvsgdtenakgqgeqgstggtnisstsepkee Proteinsequenceisoform3(SEQIDNO(62)): 1 mgttaraalvltylavasaaseggftatgqrqlrpehfqevgyaappspplsrslpmdhp 61 dssqhgppfegqsgkegrgprphsqpwlgervgcshippsivqpppsqeatplqqekllp 121 aqlpaekevgpplpqeavplqkelpslqhpneqkegtpapfgdqshpepeswnaaqhcqq 181 drsqggwghrldgfppgrpspdnlnqiclpnrqhvvygpwnlpqssyshltrqgetlnfl 241 eigysrcchcrshtnrlecaklvweeamsrfceaefsvktrphwcctrqgearfscfqee 301 apqphyqlracpshqpdissglelpfppgvptldniknichlrrfrsvprnlpatdplqr 361 ellaliqlerefqrccrqgnnhtctwkawedtldkycdreyavkthhhlccrhppsptrd 421 ecfarrapypnydrdiltidigrvtpnlmghlcgnqrvltkhkhipglihnmtarccdlp 481 fpeqaccaeeekltfindlcgprrniwrdpalccylspgdeqvncfninylrnvalvsgd 541 tenakgqgeqgstggtnisstsepkee GeneID: Y3 Genesymbol: CLDN1 Genedescription: claudin1 Unigene: Hs.439060 Genbank: AY358652 EntrezGene: 9076 Refseq: NM_021101 Proteinsequence(SEQIDNO(63)): 1 managlqllgfilaflgwigaivstalpqwriysyagdnivtaqamyeglwmscvsqstg 61 qiqckvfdsllnlsstlqatralmvvgillgviaifvatvgmkcmkcleddevqkmrmav 121 iggaifllaglailvatawygnrivqefydpmtpvnaryefgqalftgwaaaslcllgga 181 llccscprkttsyptprpypkpapssgkdyv GeneID: Y4 Genesymbol: SFN Genedescription: stratifin Unigene: Hs.523718 Genbank: AF029082 EntrezGene: 2810 Refseq: NM_006142 Proteinsequence(SEQIDNO(64)): 1 merasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqraawr 61 vlssieqksneegseekgpevreyrekvetelqgvcdtvlglldshlikeagdaesrvfy 121 lkmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfh 181 yeianspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwtadnageegg 241 eapqepqs GeneID: Y5 Genesymbol: CD9 Genedescription: CD9antigen Unigene: Hs.114286 Genbank: AY966455 EntrezGene: 928 Refseq: NM_001769 Proteinsequence(SEQIDNO(65)): 1 mpvkggtkcikyllfgfnfifwlagiavlaiglwlrfdsqtksifeqetnnnnssfytgv 61 yiligagalmmlvgflgccgavqesqcmlglffgfllvifaieiaaaiwgyshkdevike 121 vqefykdtynklktkdepqretlkaihyalnccglaggveqfisdicpkkdvletftvks 181 cpdaikevfdnkfhiigavgigiavvmifgmifsmilccairmremv GeneID: Y6 Genesymbol: CD109 Genedescription: CD109antigen Unigene: Hs.399891 Genbank: AF410459 EntrezGene: 135228 Refseq: NM_133493|NM_001159587|NM_001159588 Proteinsequenceisoform1(SEQIDNO(66)): 1 mqgpplltaahllcvctaalavapgprflvtapgiirpggnvtigvellehcpsqvtvka 61 ellktasnltvsvleaegvfekgsfktltlpslplnsadeiyelrvtgrtqdeilfsnst 121 rlsfetkrisvfiqtdkalykpkqevkfrivtlfsdfkpyktslnilikdpksnliqqwl 181 sqqsdlgvisktfqlsshpilgdwsiqvqvndqtyyqsfqvseyvlpkfevtlqtplycs 241 mnskhlngtitakytygkpvkgdvtltflplsfwgkkknitktfkingsanfsfndeemk 301 nvmdssnglseyldlsspgpveilttvtesvtgisrnvstnvffkqhdyiieffdyttvl 361 kpslnftatvkvtradgnqltleerrnnvvitvtqrnyteywsgsnsgnqkmeavqkiny 421 tvpqsgtfkiefpiledsselqlkayflgskssmavhslfkspsktyiqlktrdenikvg 481 spfelvvsgnkrlkelsymvvsrgqlvavgkqnstmfsltpenswtpkacvivyyieddg 541 eiisdvlkipvqlvfknkiklywskvkaepsekvslrisvtqpdsivgivavdksvnlmn 601 asnditmenvvhelelyntgyylgmfmnsfavfqecglwvltdanltkdyidgvydnaey 661 aerfmeeneghivdihdfslgssphvrkhfpetwiwldtnmgyriyqefevtvpdsitsw 721 vatgfvisedlglgltttpvelqafqpffiflnlpysvirgeefaleitifnylkdatev 781 kviieksdkfdilmtsneinatghqqtllvpsedgatvlfpirpthlgeipitvtalspt 841 asdavtqmilvkaegieksysqsilldltdnrlqstlktlsfsfppntvtgservqitai 901 gdvlgpsinglaslirmpygcgeqnminfapniyildyltkkkqltdnlkekalsfmrqg 961 yqrellyqredgsfsafgnydpsgstwlsafvlrcfleadpyididqnvlhrtytwlkgh 1021 qksngefwdpgrvihselqggnkspvtltayivtsllgyrkyqpnidvqesihflesefs 1081 rgisdnytlalityalssvgspkakealnmltwraeqeggmqfwvssesklsdswqprsl 1141 dievaayallshflqfqtsegipimrwlsrqrnslggfastqdttvalkalsefaalmnt 1201 ertniqvtvtgpsspspvkflidthnrlllqtaelavvqptavnisangfgfaicqlnvv 1261 ynvkasgssrrrrsiqnqeafdldvavkenkddlnhvdlnvctsfsgpgrsgmalmevnl 1321 lsgfmvpseaislsetvkkveydhgklnlyldsvnetqfcvnipavrnfkvsntqdasvs 1381 ivdyyeprrqavrsynsevklsscdlcsdvqgcrpcedgasgshhhssvififcfkllyf 1441 melwl Proteinsequenceisoform2(SEQIDNO(67)): 1 mqgpplltaahllcvctaalavapgprflvtapgiirpggnvtigvellehcpsqvtvka 61 ellktasnltvsvleaegvfekgsfktltlpslplnsadeiyelrvtgrtqdeilfsnst 121 rlsfetkrisvfiqtdkalykpkqevkfrivtlfsdfkpyktslnilikdpksnliqqwl 181 sqqsdlgvisktfqlsshpilgdwsiqvqvndqtyyqsfqvseyvlpkfevtlqtplycs 241 mnskhlngtitakytygkpvkgdvtltflplsfwgkkknitktfkingsanfsfndeemk 301 nvmdssnglseyldlsspgpveilttvtesvtgisrnvstnvffkqhdyiieffdyttvl 361 kpslnftatvkvtradgnqltleerrnnvvitvtqrnyteywsgsnsgnqkmeavqkiny 421 tvpqsgtfkiefpiledsselqlkayflgskssmavhslfkspsktyiqlktrdenikvg 481 spfelvvsgnkrlkelsymvvsrgqlvavgkqnstmfsltpenswtpkacvivyyieddg 541 eiisdvlkipvqlvfknkiklywskvkaepsekvslrisvtqpdsivgivavdksvnlmn 601 asnditmenvvhelelyntgyylgmfmnsfavfqecglwvltdanltkdyidgvydnaey 661 aerfmeeneghivdihdfslgssphvrkhfpetwiwldtnmgyriyqefevtvpdsitsw 721 vatgfvisedlglgltttpvelqafqpffiflnlpysvirgeefaleitifnylkdatev 781 kviieksdkfdilmtsneinatghqqtllvpsedgatvlfpirpthlgeipitvtalspt 841 asdavtqmilvkaegieksysqsillditdnrlqstiktlsfsfppntvtgservqitai 901 gdvlgpsinglaslirmpygcgeqnminfapniyildyltkkkqltdnlkekalsfmrqg 961 yqrellyqredgsfsafgnydpsgstwlsafvlrcfleadpyididqnvlhrtytwlkgh 1021 qksngefwdpgrvihselqggnkspvtltayivtsllgyrkyqpnidvqesihflesefs 1081 rgisdnytlalityalssvgspkakealnmltwraeqeggmqfwvssesklsdswqprsl 1141 dievaayallshflqfqtsegipimrwlsrqrnslggfastqdttvalkalsefaalmnt 1201 ertniqvtvtgpsspsplavvqptavnisangfgfaicqlnvvynvkasgssrrrrsiqn 1261 qeafdldvavkenkddlnhvdinvctsfsgpgrsgmalmevnllsgfmvpseaislsetv 1321 kkveydhgklnlyldsvnetqfcvnipavrnfkvsntqdasvsivdyyeprrqavrsyns 1381 evklsscdlcsdvqgcrpcedgasgshhhssvififcfkllyfmelwl Proteinsequenceisoform3(SEQIDNO(68)): 1 mqgpplltaahllcvctaalavapgprflvtapgiirpggnvtigvellehcpsqvtvka 61 ellktasnltvsvleaegvfekgsfktltlpsdpksnliqqwlsqqsdlgvisktfqlss 121 hpilgdwsiqvqvndqtyyqsfqvseyvlpkfevtlqtplycsmnskhingtitakytyg 181 kpvkgdvtltflplsfwgkkknitktfkingsanfsfndeemknvmdssnglseyldlss 241 pgpveilttvtesvtgisrnvstnvffkqhdyiieffdyttvlkpslnftatvkvtradg 301 nqltleerrnnvvitvtqrnyteywsgsnsgnqkmeavqkinytvpqsgtfkiefpiled 361 sselqlkayflgskssmavhslfkspsktyiqlktrdenikvgspfelwvsgnkrlkels 421 ymvvsrgqlvavgkqnstmfsltpenswtpkacvivyyieddgeiisdvlkipvqlvfkn 481 kiklywskvkaepsekvslrisvtqpdsivgivavdksvnlmnasnditmenwvhelely 541 ntgyylgmfmnsfavfqecglwvltdanltkdyidgvydnaeyaerfmeeneghivdihd 601 fslgssphvrkhfpetwiwldtnmgyriyqefevtvpdsitswvatgfvisedlglgltt 661 tpvelqafqpffiflnlpysvirgeefaleitifnylkdatevkviieksdkfdilmtsn 721 einatghqqtllvpsedgatvlfpirpthlgeipitvtalsptasdavtqmilvkaegie 781 ksysqsilldltdnrlqstlktlsfsfppntvtgservqitaigdvlgpsinglaslirm 841 pygcgeqnminfapniyildyltkkkqltdnlkekalsfmrqgyqrellyqredgsfsaf 901 gnydpsgstwlsafvlrcfleadpyididqnvlhrtytwlkghqksngefwdpgrvihse 961 lqggnkspvtltayivtsllgyrkyqpnidvqesihflesefsrgisdnytlalityals 1021 svgspkakealnmltwraeqeggmqfwvssesklsdswqprsldievaayallshflqfq 1081 tsegipimrwlsrqrnslggfastqdttvalkalsefaalmntertniqvtvtgpsspsp 1141 vkflidthnrlllqtaelavvqptavnisangfgfaicqlnvvynvkasgssrrrrsiqn 1201 qeafdldvavkenkddlnhvdinvctsfsgpgrsgmalmevnllsgfmvpseaislsetv 1261 kkveydhgklnlyldsvnetqfcvnipavrnfkvsntqdasvsivdyyeprrqavrsyns 1321 evklsscdlcsdvqgcrpcedgasgshhhssvififcfkllyfmelwl GeneID: Y7 Genesymbol: ITGB8 Genedescription: integrin,beta8 Unigene: Hs.592171 Genbank: M73780 EntrezGene: 3696 Refseq: NM_002214 Proteinsequence(SEQIDNO(69)): 1 mcgsalafftaafvclqndrrgpasflwaawvfslvlglgqgednrcassnaascarcla 61 lgpecgwcvqedfisggsrsercdivsnliskgcsvdsieypsvhviipteneintqvtp 121 gevsiqlrpgaeanfmlkvhplkkypvdlyylvdvsasmhnnieklnsvgndlsrkmaff 181 srdfrlgfgsyvdktvspyisihperihnqcsdynldcmpphgyihvlsltenitefeka 241 vhrqkisgnidtpeggfdamlqaavceshigwrkeakrillvmtdqtshlaldsklagiv 301 vpndgnchlknnvyvksttmehpslgqlseklidnninvifavqgkqfhwykdllpllpg 361 tiageieskaanlnnlvveayqklisevkvqvenqvqgiyfnitaicpdgsrkpgmeger 421 nvtsndevlfnvtvtmkkcdvtggknyaiikpigfnetakihihrncscqcednrgpkgk 481 cvdetfldskcfqcdenkchfdedqfssesckshkdqpvcsgrgvcvcgkcschkiklgk 541 vygkycekddfscpyhhgnlcaghgeceagrcqcfsgwegdrcqcpsaaaqhcvnskgqv 601 csgrgtcvcgrcectdprsigrfcehcptcytackenwncmqclhphnlsqaildqckts 661 calmeqqhyvdqtsecfsspsylriffiifivtfligllkvliirqvilqwnsnkiksss 721 dyrvsaskkdklilqsvctravtyrrekpeeikmdisklnahetfrcnf GeneID: Y8 Genesymbol: EMP2 Genedescription: epithelialmembraneprotein2 Unigene: Hs.531561 Genbank: BC009687 EntrezGene: 2013 Refseq: NM_001424 Proteinsequence(SEQIDNO(70)): 1 mlvllafiiafhitsaallfiatvdnawwvgdeffadvwrictnntnctvindsfqeyst 61 lqavqatmilstilcciaffifvlqlfrlkqgerfvltsiiqlmsclcvmiaasiytdrr 121 edihdknakfypvtregsygysyilawvafactfisgmmylilrkrk GeneID: Y9 Genesymbol: FGFBP1 Genedescription: fibroblastgrowthfactorbindingprotein1 Unigene: Hs.1690 Genbank: BC008910 EntrezGene: 9982 Refseq: NM_005130 Proteinsequence(SEQIDNO(71)): 1 mkicsltllsflllaaqvllvegkkkvknglhskvvseqkdtlgntqikqksrpgnkgkf 61 vtkdqancrwaateqeegislkvectqldhefscvfagnptsclklkdervywkqvarnl 121 rsqkdicrysktavktrvcrkdfpessiklvsstlfgntkprkektemsprehikgkett 181 psslavtqtmatkapecvedpdmanqrktalefcgetwsslctfflsivqdtsc GeneID: Y10 Genesymbol: CDH3 Genedescription: cadherin3,type1,P-cadherin(placental) Unigene: Hs.191842 Genbank: BC041846 EntrezGene: 1001 Refseq: NM_001793 Proteinsequence(SEQIDNO(72)): 1 mglprgplasllllqvcwlqcaasepcravfreaevtleaggaeqepgqalgkvfmgcpg 61 qepalfstdnddftvrngetvqerrslkernplkifpskrilrrhkrdwvvapisvpeng 121 kgpfpqrinqlksnkdrdtkifysitgpgadsppegvfaveketgwlllnkpldreeiak 181 yelfghavsengasvedpmnisiivtdqndhkpkftqdtfrgsvlegvlpgtsvmqvtat 241 deddaiytyngvvaysihsqepkdphdlmftihrstgtisvissgldrekvpeytltiqa 301 tdmdgdgstttavavveildandnapmfdpqkyeahvpenavghevqrltvtdldapnsp 361 awratylimggddgdhftitthpesnqgilttrkgldfeaknqhtlyvevtneapfvlkl 421 ptstativvhvedvneapvfvppskvvevqegiptgepvcvytaedpdkenqkisyrilr 481 dpagwlamdpdsgqvtavgtldredeqfvrnniyevmvlamdngsppttgtgtllltlid 541 vndhgpvpeprqiticnqspvrqvlnitdkdlsphtspfqaqltddsdiywtaevneegd 601 tvvlslkkflkqdtydvhlslsdhgnkeqltviratvcdchghvetcpgpwkggfilpvl 661 gavlallflllvllllvrkkrkikeplllpeddtrdnvfyygeegggeedqdyditqlhr 721 glearpevvlrndvaptiiptpmyrprpanpdeignfiienlkaantdptappydtllvf 781 dyegsgsdaaslssltssasdqdqdydylnewgsrfkkladmygggedd GeneID: Y11 Genesymbol: ITGB4 Genedescription: integrin,beta4 Unigene: Hs.632226 Genbank: X53587 EntrezGene: 3691 Refseq: NM_000213|NM_001005619|NM_001005731 Proteinsequenceisoform1(SEQIDNO(73)): 1 magprpspwarlllaalisvslsgtlanrckkapvksctecvrvdkdcayctdemfrdrr 61 cntqaellaagcqresivvmessfqiteetqidttirrsqmspqglrvrlrpgeerhfel 121 evfeplespvdlyilmdfsnsmsddldnikkmgqnlarvlsqltsdytigfgkfvdkvsv 181 pqtdmrpeklkepwpnsdppfsfknvisitedvdefrnklqgerisgnldapeggfdail 241 qtavctrdigwrpdsthllvfstesafhyeadganvlagimsrnderchldttgtytqyr 301 tqdypsvptlvrllakhniipifavtnysysyyeklhtyfpvsslgvlqedssnivelle 361 eafnrirsnldiraldsprglrtevtskmfqktrtgsfhirrgevgiyqvqlralehvdg 421 thvcqlpedqkgnihlkpsfsdglkmdagiicdvctcelqkevrsarcsfngdfvcgqcv 481 csegwsgqtcnestgslsdiqpclregedkpcsgrgecqcghcvcygegryegqfceydn 541 fqcprtsgflcndrgresmgqcvcepgwtgpscdcplsnatcidsnggicngrghcecgr 601 chchqqslytdticeinysaihpglcedirscvqcqawgtgekkgrtceecnfkvkmvde 661 lkraeevvvrcsfrdedddctysytmegdgapgpnstvlvhkkkdcppgsfwwlipllll 721 llpllalllllcwkycacckaclallpccnrghmvgfkedhymlrenlmasdhldtpmlr 781 sgnlkgrdvvrwkvtnnmqrpgfathaasinptelvpyglsirlarictenilkpdtrec 841 aqlrqeveenlnevyrqisgvhklqqtkfrqqpnagkkqdhtivdtvlmaprsakpallk 901 ltekqveqrafhdlkvapgyytltadqdargmvefqegvelvdvrvplfirpedddekql 961 lveaidvpagtatlgrrlvnitiikeqardvvsfeqpefsvsrgdqvaripvirrvldgg 1021 ksqvsyrtqdgtaqgnrdyipvegellfqpgeawkelqvkllelqevdsllrgrqvrrfh 1081 vqlsnpkfgahlgqphsttiiirdpdeldrsftsqmlssqppphgdlgapqnpnakaags 1141 rkihfnwlppsgkpmgyrvkywiqgdseseahlldskvpsveltnlypycdyemkvcayg 1201 aqgegpysslvscrthqevpsepgrlafnvvsstvtqlswaepaetngeitayevcyglv 1261 nddnrpigpmkkvlvdnpknrmllienlresqpyrytvkarngagwgpereaiinlatqp 1321 krpmsipiipdipivdaqsgedydsflmysddvirspsgsqrpsvsddtgcgwkfepllg 1381 eeldlrrvtwrlppeliprrsassgrssdaeaphgppddggaggkggslprsatpgppge 1441 hlvngrmdfafpgstnslhrmtttsaaaygthisphvphrvlstsstltrdynsltrseh 1501 shsttlprdystltsvsshdsrltagvpdtptrivfsalgptslrvswqeprcerplqgy 1561 sveyqllnggelhrlnipnpaqtsvvvedllpnhsyvfrvraqsqegwgreregvities 1621 qvhpqsplcplpgsaftistpsapgplvftalspdslqlswerprrpngdivgylvtcem 1681 aqgggpatafrvdgdspesrltvpglsenvpykfkvqarttegfgperegiitiesqdgg 1741 pfpqlgsraglfqhplqseyssittthtsatepflvdgltlgaqhleaggsltrhvtqef 1801 vsrtlttsgtlsthmdqqffqt Proteinsequenceisoform2(SEQIDNO(74)): 1 magprpspwarlllaalisvslsgtlanrckkapvksctecvrvdkdcayctdemfrdrr 61 cntqaellaagcqresivvmessfqiteetqidttlrrsqmspqglrvrlrpgeerhfel 121 evfeplespvdlyilmdfsnsmsddldnikkmgqnlarvlsqltsdytigfgkfvdkvsv 181 pqtdmrpeklkepwpnsdppfsfknvisltedvdefrnklqgerisgnldapeggfdail 241 qtavctrdigwrpdsthllvfstesafhyeadganvlagimsrnderchldttgtytqyr 301 tqdypsvptlvrllakhniipifavtnysysyyeklhtyfpvsslgvlqedssnivelle 361 eafnrirsnldiraldsprglrtevtskmfqktrtgsfhirrgevgiyqvqlralehvdg 421 thvcqlpedqkgnihlkpsfsdglkmdagiicdvctcelqkevrsarcsfngdfvcgqcv 481 csegwsgqtcncstgslsdiqpclregedkpcsgrgecqcghcvcygegryegqfceydn 541 fqcprtsgflcndrgresmgqcvcepgwtgpscdcplsnatcidsnggicngrghcecgr 601 chchqqslytdticeinysaihpglcedlrscvqcqawgtgekkgrtceecnfkvkmvde 661 lkraeevvvrcsfrdedddctysytmegdgapgpnstvlvhkkkdcppgsfwwlipllll 721 llpllalllllcwkycacckaclallpccnrghmvgfkedhymlrenlmasdhldtpmlr 781 sgnlkgrdvvrwkvtnnmqrpgfathaasinptelvpyglslrlarlctenllkpdtrec 841 aqlrqeveenlnevyrqisgvhklqqtkfrqqpnagkkqdhtivdtvlmaprsakpallk 901 ltekqveqrafhdlkvapgyytltadqdargmvefqegvelvdvrvplfirpedddekql 961 lveaidvpagtatlgrrlvnitiikeqardvvsfeqpefsvsrgdqvaripvirrvldgg 1021 ksqvsyrtqdgtaqgnrdyipvegellfqpgeawkelqvkllelqevdsllrgrqvrrfh 1081 vqlsnpkfgahlgqphsttiiirdpdeldrsftsqmlssqppphgdlgapqnpnakaags 1141 rkihfnwlppsgkpmgyrvkywiqgdseseahlldskvpsveltnlypycdyemkvcayg 1201 aqgegpysslvscrthqevpsepgrlafnvvsstvtqlswaepaetngeitayevcyglv 1261 nddnrpigpmkkvlvdnpknrmllienlresqpyrytvkarngagwgpereaiinlatqp 1321 krpmsipiipdipivdaqsgedydsflmysddvlrspsgsqrpsvsddtehlvngrmdfa 1381 fpgstnslhrmtttsaaaygthisphvphrvlstsstltrdynsltrsehshsttlprdy 1441 stltsvsshglppiwehgrsrlplswalgsrsraqmkgfppsrgprdsiilagrpaapsw 1501 gpdsrltagvpdtptrlvfsalgptsirvswqeprcerplqgysveyqllnggelhrlni 1561 pnpaqtsvvvedllpnhsyvfrvraqsqegwgreregvitiesqvhpqsplcplpgsaft 1621 lstpsapgplvftalspdslqlswerprrpngdivgylvtcemaqgggpatafrvdgdsp 1681 esrltvpglsenvpykfkvqarttegfgperegiitiesqdggpfpqlgsraglfqhplq 1741 seyssittthtsatepflvdgltlgaqhleaggsltrhvtqefvsrtlttsgtlsthmdq 1801 qffqt Proteinsequenceisoform3(SEQIDNO(75)): 1 magprpspwarlllaalisvslsgtlanrckkapvksctecvrvdkdcayctdemfrdrr 61 cntqaellaagcqresivvmessfqiteetqidttlrrsqmspqglrvrlrpgeerhfel 121 evfeplespvdlyilmdfsnsmsddldnikkmgqnlarvlsqltsdytigfgkfvdkvsv 181 pqtdmrpeklkepwpnsdppfsfknvisitedvdefrnklqgerisgnldapeggfdail 241 qtavctrdigwrpdsthllvfstesafhyeadganvlagimsrnderchldttgtytqyr 301 tqdypsvptlvrllakhniipifavtnysysyyeklhtyfpvsslgvlqedssnivelle 361 eafnrirsnldiraldsprglrtevtskmfqktrtgsfhirrgevgiyqvqlralehvdg 421 thvcqlpedqkgnihlkpsfsdglkmdagiicdvctcelqkevrsarcsfngdfvcgqcv 481 csegwsgqtcncstgslsdiqpclregedkpcsgrgecqcghcvcygegryegqfceydn 541 fqcprtsgflcndrgrcsmgqcvcepgwtgpscdcplsnatcidsnggicngrghcecgr 601 chchqqslytdticeinysaihpglcedlrscvqcqawgtgekkgrtceecnfkvkmvde 661 lkraeevvvrcsfrdedddctysytmegdgapgpnstvlvhkkkdcppgsfwwlipllll 721 llpllalllllcwkycacckaclallpccnrghmvgfkedhymlrenlmasdhldtpmlr 781 sgnlkgrdvvrwkvtnnmqrpgfathaasinptelvpyglsirlarictenllkpdtrec 841 aqlrqeveenlnevyrqisgvhklqqtkfrqqpnagkkqdhtivdtvlmaprsakpallk 901 ltekqveqrafhdlkvapgyytltadqdargmvefqegvelvdvrvplfirpedddekql 961 lveaidvpagtatlgrrlvnitiikeqardwvsfeqpefsvsrgdqvaripvirrvldgg 1021 ksqvsyrtqdgtaqgnrdyipvegellfqpgeawkelqvkllelqevdsllrgrqvrrfh 1081 vqlsnpkfgahlgqphsttiiirdpdeldrsftsqmissqppphgdlgapqnpnakaags 1141 rkihfnwlppsgkpmgyrvkywiqgdseseahlldskvpsveltnlypycdyemkvcayg 1201 aqgegpysslvscrthqevpsepgrlafnvvsstvtqlswaepaetngeitayevcyglv 1261 nddnrpigpmkkvlvdnpknrmllienlresqpyrytvkarngagwgpereaiinlatqp 1321 krpmsipiipdipivdaqsgedydsflmysddvlrspsgsqrpsvsddtehlvngrmdfa 1381 fpgstnslhrmtttsaaaygthisphvphrvlstsstltrdynsltrsehshsttlprdy 1441 stltsvsshdsrltagvpdtptrivfsalgptslrvswqeprcerplqgysveyqllngg 1501 elhrlnipnpaqtsvwvedllpnhsyvfrvraqsqegwgreregvitiesqvhpqsplcp 1561 lpgsaftlstpsapgplvftalspdslqlswerprrpngdivgylvtcemaqgggpataf 1621 rvdgdspesrltvpglsenvpykfkvqarttegfgperegiitiesqdggpfpqlgsrag 1681 lfqhplqseyssittthtsatepflvdgltlgaqhleaggsltrhvtqefvsrtlttsgt 1741 lsthmdqqffqt GeneID: Y12 Genesymbol: LAMB3 Genedescription: laminin,beta3 Unigene: Hs.497636 Genbank: BC075838 EntrezGene: 3914 Refseq: NM_000228 Proteinsequence(SEQIDNO(76)): 1 mrpffllcfalpgllhaqqacsrgacyppvgdllvgrtrflrasstcgltkpetyctqyg 61 ewqmkcckcdsrqphnyyshrvenvasssgpmrwwqsqndvnpvslqldldrrfqlqevm 121 mefqgpmpagmlierssdfgktwrvyqylaadctstfprvrqgrpqswqdvrcqslpqrp 181 narlnggkvqlnlmdlvsgipatqsqkiqevgeitnlrvnftrlapvpqrgyhppsayya 241 vsqlrlqgscfchghadrcapkpgasagpstavqvhdvcvcqhntagpncercapfynnr 301 pwrpaegqdahecqrcdcnghsetchfdpavfaasqgayggvcdncrdhtegkncercql 361 hyfrnrrpgasiqetciscecdpdgavpgapcdpvtgqcvckehvqgercdickpgftgl 421 tyanpqgchrcdcnilgsrrdmpcdeesgrclclpnvvgpkcdqcapyhwklasgqgcep 481 cacdphnslspqcnqftgqcpcregfggimcsaaairqcpdrtygdvatgcracdcdfrg 541 tegpgcdkasgrclcrpgltgpredqcqrgycnrypvcvachpcfqtydadlreqalrfg 601 rlrnataslwsgpgledrglasrildakskieqiravlsspavteqevaqvasailslrr 661 tlqglqldipleeetlsiprdlesidrsfnglltmyqrkreqfekissadpsgafrmlst 721 ayeqsaqaaqqvsdssrlldqlrdsrreaerlvrqagggggtgspklvalrlemsslpdl 781 tptfnklcgnsrqmactpiscpgelcpqdngtacgsrcrgvlpraggaflmagqvaeqlr 841 gfnaqlqrtrqmiraaeesasqiqssaqrletqvsasrsqmeedvrrtrlliqqvrdflt 901 dpdtdaatiqevseavlalwlptdsatvlqkmneiqaiaarlpnvdlvlsqtkqdiarar 961 rlqaeaeearsrahavegqvedvvgnlrqgtvalqeaqdtmqgtsrslrliqdrvaevqq 1021 vlrpaeklvtsmtkqlgdfwtrmeelrhqarqqgaeavqaqqlaegaseqalsaqegfer 1081 ikqkyaelkdrlgqssmlgeqgariqsvkteaeelfgetmemmdrmkdmelellrgsqai 1141 mlrsadltglekrveqirdhingrvlyyatck GeneID: Y13 Genesymbol: CD55 Genedescription: CD55antigen Unigene: Hs.126517 Genbank: M31516 EntrezGene: 1604 Refseq: NM_000574 Proteinsequence(SEQIDNO(77)): 1 mtvarpsvpaalpllgelprllllvllclpavwgdcglppdvpnaqpalegrtsfpedtv 61 itykceesfvkipgekdsviclkgsqwsdieefcnrscevptrinsaslkqpyitqnyfp 121 vgtvveyecrpgyrrepslspkltclqnlkwstavefckkkscpnpgeirngqidvpggi 181 lfgatisfscntgyklfgstssfclisgssvqwsdplpecreiycpappqidngiiqger 241 dhygyrqsvtyacnkgftmigehsiyctvnndegewsgpppecrgksltskvpptvqkpt 301 tvnvpttevsptsqktttktttpnaqatrstpvsrttkhfhettpnkgsgttsgttrlls 361 ghtcftltgllgtlvtmgllt GeneID: Y14 Genesymbol: CLDN16 Genedescription: claudin16 Unigene: Hs.251391 Genbank: BC069682 EntrezGene: 10686 Refseq: NM_006580 Proteinsequence(SEQIDNO(78)): 1 mtsrtpllvtaclyysycnsrhlqqgvrkskrpvfshcqvpetqktdtrhlsgaragvcp 61 cchpdgllatmrdllqyiacffaffsagflivatwtdcwmvnaddslevstkcrglwwec 121 vtnafdgirtcdeydsilaehplklvvtralmitadilagfgfltlllgldcvkflpdep 181 yikvricfvagatlliagtpgiigsvwyavdvyverstlvlhniflgiqykfgwscwlgm 241 agslgcflagavltcclylfkdvgpernypyslrkaysaagvsmaksysaprtetakmya 301 vdtrv GeneID: Y15 Genesymbol: LAMA3 Genedescription: laminin,alpha3 Unigene: Hs.436367 Genbank: AY327115 EntrezGene: 3909 Refseq: NM_198129|NM_001127717|NM_000227|NM_001127718 Proteinsequenceisoform1(SEQIDNO(79)): 1 maaaarprgralgpvlpptpllllvlrvlpacgatardpgaaaglslhptyfnlaeaari 61 watatcgergpgegrpqpelycklvggptapgsghtiqgqfcdycnsedprkahpvtnai 121 dgserwwqspplssgtqynrvnltldlgqlfhvayilikfansprpdlwvlersvdfgst 181 yspwqyfahskvdclkefgreanmavtrdddvlcvteysrivplengevvvslingrpga 241 knftfshtlreftkatnirlrflrtntllghliskaqrdptvtrryyysikdisiggqcv 301 cnghaevcninnpeklfrcecqhhtcgetcdrcctgynqrrwrpaaweqsheceacnchg 361 hasncyydpdverqqasintqgiyagggvcincqhntagvnceqcakgyyrpygvpvdap 421 dgcipcscdpehadgceqgsgrchckpnfhgdncekcaigyynfpfclripifpvstpss 481 edpvagdikgcdcnlegvlpeicdahgrclcrpgvegprcdtcrsgfysfpicqacwcsa 541 lgsyqmpcssvtgqcecrpgvtgqrcdrelsgaydfphcqgsssacdpagtinsnlgycq 601 cklhvegptcsrckllywnldkenpsgcseckchkagtvsgtgecrqgdgdchckshvgg 661 dscdtcedgyfaleksnyfgcqgcqcdiggalssmcsgpsgvcqcrehwwgkvcqrpenn 721 yyfpdlhhmkyeiedgstpngrdlrfgfdplafpefswrgyaqmtsvqndvritlnvgks 781 sgslfrvilryvnpgteavsghitiypswgaaqskeiiflpskepafvtvpgngfadpfs 841 itpgiwvacikaegvlldylvilprdyyeasviqlpvtepcayagppqencllyqhlpvt 901 rfpctlacearhflldgeprpvavrqptpahpvmvdlsgrevelhirlripqvghyvvvv 961 eysteaaqlfvvdvnvkssgsvlagqvniyscnysvlcrsavidhmsriamyelladadi 1021 qlkghmarfllhqvciipieefsaeyvrpqvhciasygrfvnqsatcvslahetpptali 1081 ldvlsgrpfphlpqqsspsvdvlpgvtlkapqnqvtlrgrvphlgryvfvihfyqaahpt 1141 fpaqvsvdggwpragsfhasfcphvlgcrdqviaegqiefdisepevaatvkvpegkslv 1201 lvrvlvvpaenydyqilhkksmdkslefitncgknsfyldpqtasrfcknsarslvafyh 1261 kgalpcechptgatgphcspeggqcpcqpnvigrqctrcatghygfprckpcscgrrice 1321 emtgqcrepprtvrpqcevcethsfsfhpmagcegencsrrgtieaampecdrdsgqcrc 1381 kpritgrqcdrcasgfyrfpecvpcncnrdgtepgvcdpgtgaclckenvegtecnvcre 1441 gsfhldpanlkgctscfcfgvnnqchsshkrrtkfvdmlgwhletadrvdipvsfnpgsn 1501 smvadlqelpatihsaswvaptsylgdkvssyggyltyqaksfglpgdmvllekkpdvql 1561 tgqhmsiiyeetntprpdrlhhgrvhvvegnfrhassrapvsreelmtvlsrladvriqg 1621 lyftetqritlsevgleeasdtgsgrialaveicacppayagdscqgcspgyyrdhkgly 1681 tgrcvpcncnghsnqcqdgsgicvncqhntagehcercqegyygnavhgscracpcphtn 1741 sfatgcvvnggdvrcsckagytgtqcercapgyfgnpqkfggscqpcscnsngqlgschp 1801 ltgdcinqepkdsspaeecddcdscvmtllndlatmgeqlrlvksqlqglsasaglleqm 1861 rhmetqakdlrnqllnyrsaisnhgskieglereltdlnqefetlqekaqvnsrkaqtln 1921 nnvnratqsakeldvkiknvirnvhillkqisgtdgegnnvpsgdfsrewaeaqrmmrel 1981 rnrnfgkhlreaeadkresqlllnrirtwqkthqgennglansirdslneyeaklsdlra 2041 rlqeaaaqakqanglngeneralgaiqrqvkeinslqsdftkylttadssllqtnialql 2101 meksqkeyeklaaslnearqelsdkvrelsrsagktslveeaekharslqelakqleeik 2161 rnasgdelvrcavdaatayenilnaikaaedaanraasasesalqtvikedlprkaktls 2221 snsdklineakmtqkklkqevspalnnlqqtlnivtvqkevidtnittlrdglhgiqrgd 2281 idamissaksmvrkanditdevldglnpiqtdverikdtygrtqnedfkkaltdadnsvn 2341 kltnklpdlwrkiesinqqllplgnisdnmdrireliqqardaaskvavpmrfngksgve 2401 vrlpndledlkgytslslflqrpnsrenggtenmfvmylgnkdasrdyigmavvdgqltc 2461 vynlgdreaelqvdqiltksetkeavmdrvkfqriyqfarlnytkgatsskpetpgvydm 2521 dgrnsntllnldpenvvfyvggyppdfklpsrlsfppykgcielddlnenvislynfkkt 2581 fnlnttevepcrrrkeesdknyfegtgyarvptqphapiptfgqtiqttvdrgllffaen 2641 gdrfislniedgklmvryklnselpkergvgdainngrdhsiqikigklqkrmwinvdvq 2701 ntiidgevfdfstyylggipiairerfnistpafrgcmknlkktsgwvrlndtvgvtkkc 2761 sedwklvrsasfsrggqlsftdlglpptdhlqasfgfqtfqpsgilldhqtwtrnlqvtl 2821 edgyielstsdsgspifkspqtymdgllhyvsvisdnsglrlliddqllrnskrlkhiss 2881 srqslriggsnfegcisnvfvqrlslspevldltsnsikrdvslggcsinkppflmllkg 2941 strfnktktfrinqllqdtpvasprsvkvwqdacsplpktqanhgalqfgdiptshllfk 3001 lpqellkprsqfavdmqttssrglvfhtgtknsfmalylskgrlvfalgtdgkklriksk 3061 ekcndgkwhtvvfghdgekgrlvvdglraregslpgnstisirapvylgsppsgkpkslp 3121 tnsfvgclknfqldskplytpsssfgvssclggplekgiyfseegghvvlahsvllgpef 3181 klvfsirprsltgilihigsqpgkhlcvyleagkvtasmdsgaggtstsvtpkqslcdgq 3241 whsvavtikqhilhleldtdssytagqipfppastqeplhlggapanlttlripvwksff 3301 gclrnihvnhipvpvtealevqgpvslngcpdq Proteinsequenceisoform3(SEQIDNO(80)): 1 maaaarprgralgpvlpptpllllvlrvlpacgatardpgaaaglslhptyfnlaeaari 61 watatcgergpgegrpqpelycklvggptapgsghtiqgqfcdycnsedprkahpvtnai 121 dgserwwqspplssgtqynrvnitldlgqlfhvayilikfansprpdlwvlersvdfgst 181 yspwqyfahskvdclkefgreanmavtrdddvlcvteysrivplengevvvslingrpga 241 knftfshtlreftkatnirlrflrtntllghliskaqrdptvtrryyysikdisiggqcv 301 cnghaevcninnpeklfrcecqhhtcgetcdrectgynqrrwrpaaweqsheceacnchg 361 hasncyydpdverqqasintqgiyagggvcincqhntagvnceqcakgyyrpygvpvdap 421 dgcipcscdpehadgceqgsgrchckpnfhgdncekcaigyynfpfclripifpvstpss 481 edpvagdikgcdcnlegvlpeicdahgrelcrpgvegprcdtcrsgfysfpicqacwcsa 541 lgsyqmpcssvtgqcecrpgvtgqrcdrelsgaydfphcqgsssacdpagtinsnlgycq 601 cklhvegptcsrckllywnldkenpsgcseckchkagtvsgtgecrqgdgdchckshvgg 661 dscdtcedgyfaleksnyfgcqgcqcdiggalssmcsgpsgvcqcrehwwgkvcqrpenn 721 yyfpdlhhmkyeiedgstpngrdlrfgfdplafpefswrgyaqmtsvqndvritinvgks 781 sgslfrvilryvnpgteavsghitiypswgaaqskeiiflpskepafvtvpgngfadpfs 841 itpgiwvacikaegvlldylvilprdyyeasviqlpvtepcayagppqencllyqhlpvt 901 rfpctlacearhflldgeprpvavrqptpahpvmvdlsgrevelhirlripqvghyvvvv 961 eysteaaqlfvvdvnvkssgsvlagqvniyscnysvlcrsavidhmsriamyelladadi 1021 qlkghmarfllhqvciipieefsaeyvrpqvhciasygrfvnqsatcvslahetpptali 1081 ldvlsgrpfphlpqqsspsvdvlpgvtlkapqnqvtlrgrvphlgryvfvihfyqaahpt 1141 fpaqvsvdggwpragsfhasfcphvlgerdqviaegqiefdisepevaatvkvpegkslv 1201 lvrvlvvpaenydyqilhkksmdkslefitncgknsfyldpqtasrfcknsarslvafyh 1261 kgalpcechptgatgphcspeggqcpcqpnvigrqctrcatghygfprckpcscgrrice 1321 emtgqcrepprtvrpqcevcethsfsfhpmagcegencsrrgtieaampecdrdsgqcrc 1381 kpritgrqcdrcasgfyrfpecvpcncnrdgtepgvcdpgtgaclckenvegtecnvcre 1441 gsfhldpanlkgctscfcfgvnnqchsshkrrtkfvdmlgwhletadrvdipvsfnpgsn 1501 smvadlqelpatihsaswvaptsylgdkvssyggyltyqaksfglpgdmvllekkpdvql 1561 tgqhmsiiyeetntprpdrlhhgrvhwvegnfrhassrapvsreelmtvlsrladvriqg 1621 lyftetqrltlsevgleeasdtgsgrialaveicacppayagdscqgcspgyyrdhkgly 1681 tgrcvpcncnghsnqcqdgsgicvncqhntagehcercqegyygnavhgscracpcphtn 1741 sfatgcvvnggdvresckagytgtqcercapgyfgnpqkfggscqpcsensngqlgschp 1801 ltgdcinqepkdsspaeecddcdscvmtllndlatmgeqlrlvksqlqglsasaglleqm 1861 rhmetqakdlrnqllnyrsaisnhgskieglereltdlnqefetlqekaqvnsrkaqtln 1921 nnvnratqsakeldvkiknvirnvhmlnrirtwqkthqgennglansirdslneyeakls 1981 dlrarlqeaaaqakqanglngeneralgaiqrqvkeinslqsdftkylttadssllqtni 2041 alqlmeksqkeyeklaaslnearqelsdkvrelsrsagktslveeaekharslqelakql 2101 eeikrnasgdelvrcavdaatayenilnaikaaedaanraasasesalqtvikedlprka 2161 ktlssnsdkllneakmtqkklkqevspalnnlqqtinivtvqkevidtnlttlrdglhgi 2221 qrgdidamissaksmvrkanditdevldglnpiqtdverikdtygrtqnedfkkaltdad 2281 nsvnkltnklpdlwrkiesinqqllplgnisdnmdrireliqqardaaskvavpmrfngk 2341 sgvevrlpndledlkgytslslflqrpnsrenggtenmfvmylgnkdasrdyigmavvdg 2401 qltcvynlgdreaelqvdqiltksetkeavmdrvkfqriyqfarlnytkgatsskpetpg 2461 vydmdgrnsntllnldpenvvfyvggyppdfklpsrlsfppykgcielddlnenvlslyn 2521 fkktfninttevepcrrrkeesdknyfegtgyarvptqphapiptfgqtiqttvdrgllf 2581 faengdrfislniedgklmvryklnselpkergvgdainngrdhsiqikigklqkrmwin 2641 vdvqntiidgevfdfstyylggipiairerfnistpafrgcmknlkktsgwvrindtvgv 2701 tkkcsedwklvrsasfsrggqlsftdlglpptdhlqasfgfqtfqpsgilldhqtwtrnl 2761 qvtledgyielstsdsgspifkspqtymdgllhyvsvisdnsglrlliddqllrnskrik 2821 hisssrqslrlggsnfegcisnvfvqrlslspevldltsnslkrdvslggcslnkppflm 2881 llkgstrfnktktfrinqllqdtpvasprsvkvwqdacsplpktqanhgalqfgdiptsh 2941 llfklpqellkprsqfavdmqttssrglvfhtgtknsfmalylskgrlvfalgtdgkklr 3001 ikskekcndgkwhtvvfghdgekgrlvvdglraregslpgnstisirapvylgsppsgkp 3061 kslptnsfvgclknfqldskplytpsssfgvssclggplekgiyfseegghvvlahsvll 3121 gpefklvfsirprsltgilihigsqpgkhlcvyleagkvtasmdsgaggtstsvtpkqsl 3181 cdgqwhsvavtikqhilhleldtdssytagqipfppastqeplhlggapanlttlripvw 3241 ksffgclrnihvnhipvpvtealevqgpvslngcpdq Proteinsequenceisoform2(SEQIDNO(81)): 1 mppavrrsacsmgwlwifgaalgqclgyssqqqrvpflqppgqsqlqasyvefrpsqgcs 61 pgyyrdhkglytgrcvpcncnghsnqcqdgsgicvncqhntagehcercqegyygnavhg 121 scracpcphtnsfatgcvvnggdvrcsckagytgtqcercapgyfgnpqkfggscqpcsc 181 nsngqlgschpltgdcinqepkdsspaeecddcdscvmtllndlatmgeqlrlvksqlqg 241 lsasaglleqmrhmetqakdlrnqllnyrsaisnhgskieglereltdlnqefetlqeka 301 qvnsrkaqtlnnnvnratqsakeldvkiknvirnvhillkqisgtdgegnnvpsgdfsre 361 waeaqrmmrelrnrnfgkhlreaeadkresqlllnrirtwqkthqgennglansirdsln 421 eyeaklsdlrarlqeaaaqakqanglngeneralgaiqrqvkeinslqsdftkylttads 481 sllqtnialqlmeksqkeyeklaaslnearqelsdkvrelsrsagktslveeaekharsl 541 qelakqleeikrnasgdelvrcavdaatayenilnaikaaedaanraasasesalqtvik 601 edlprkaktlssnsdkllneakmtqkklkqevspalnnlqqtlnivtvqkevidtnlttl 661 rdglhgiqrgdidamissaksmvrkanditdevldglnpiqtdverikdtygrtqnedfk 721 kaltdadnsvnkltnklpdlwrkiesinqqllplgnisdnmdrireliqqardaaskvav 781 pmrfngksgvevripndledlkgytslslflqrpnsrenggtenmfvmylgnkdasrdyi 841 gmavvdgqltcvynlgdreaelqvdqiltksetkeavmdrvkfqriyqfarlnytkgats 901 skpetpgvydmdgrnsntllnldpenvvfyvggyppdfklpsrlsfppykgcielddlne 961 nvlslynfkktfnlnttevepcrrrkeesdknyfegtgyarvptqphapiptfgqtiqtt 1021 vdrgliffaengdrfislniedgklmvryklnselpkergvgdainngrdhsiqikigkl 1081 qkrmwinvdvqntiidgevfdfstyylggipiairerfnistpafrgcmknlkktsgvvr 1141 lndtvgvtkkcsedwklvrsasfsrggqlsftdlglpptdhlqasfgfqtfqpsgilldh 1201 qtwtrnlqvtledgyielstsdsgspifkspqtymdgllhyvsvisdnsglrlliddqll 1261 rnskrikhisssrqslrlggsnfegcisnvfvqrlslspevldltsnslkrdvslggcsl 1321 nkppflmilkgstrfnktktfrinqllqdtpvasprsvkvwqdacsplpktqanhgalqf 1381 gdiptshllfklpqellkprsqfavdmqttssrglvfhtgtknsfmalylskgrlvfalg 1441 tdgkklrikskekcndgkwhtvvfghdgekgrlvvdglraregslpgnstisirapvylg 1501 sppsgkpkslptnsfvgclknfqldskplytpsssfgvssclggplekgiyfseegghvv 1561 lahsvllgpefklvfsirprsltgilihigsqpgkhlcvyleagkvtasmdsgaggtsts 1621 vtpkqslcdgqwhsvavtikqhilhleldtdssytagqipfppastqeplhlggapanlt 1681 tlripvwksffgclrnihvnhipvpvtealevqgpvslngcpdq Proteinsequenceisoform4(SEQIDNO(82)): 1 mppavrrsacsmgwlwifgaalgqclgyssqqqrvpflqppgqsqlqasyvefrpsqgcs 61 pgyyrdhkglytgrcvpcncnghsnqcqdgsgicvncqhntagehcercqegyygnavhg 121 scracpcphtnsfatgcvvnggdvresckagytgtqcercapgyfgnpqkfggscqpcsc 181 nsngqlgschpltgdcinqepkdsspaeecddcdscvmtllndlatmgeqlrlvksqlqg 241 lsasaglleqmrhmetqakdlrnqllnyrsaisnhgskieglereltdlnqefetlqeka 301 qvnsrkaqtlnnnvnratqsakeldvkiknvirnvhmlnrirtwqkthqgennglansir 361 dslneyeaklsdlrarlqeaaaqakqanglngeneralgaiqrqvkeinslqsdftkylt 421 tadssllqtnialqlmeksqkeyeklaaslnearqelsdkvrelsrsagktslveeaekh 481 arslqelakqleeikrnasgdelvrcavdaatayenilnaikaaedaanraasasesalq 541 tvikediprkaktlssnsdkllneakmtqkklkqevspalnnlqqtlnivtvqkevidtn 601 lttlrdglhgiqrgdidamissaksmvrkanditdevldglnpiqtdverikdtygrtqn 661 edfkkaltdadnsvnkltnklpdlwrkiesinqqllplgnisdnmdrireliqqardaas 721 kvavpmrfngksgvevripndledlkgytslslflqrpnsrenggtenmfvmylgnkdas 781 rdyigmavvdgqltcvynlgdreaelqvdqiltksetkeavmdrvkfqriyqfarlnytk 841 gatsskpetpgvydmdgrnsntlinldpenvvfyvggyppdfklpsrlsfppykgcield 901 dlnenvislynfkktfninttevepcrrrkeesdknyfegtgyarvptqphapiptfgqt 961 iqttvdrgllffaengdrfislniedgklmvryklnselpkergvgdainngrdhsiqik 1021 igklqkrmwinvdvqntiidgevfdfstyylggipiairerfnistpafrgcmknlkkts 1081 gvvrindtvgvtkkcsedwklvrsasfsrggqlsftdlglpptdhlqasfgfqtfqpsgi 1141 lldhqtwtrnlqvtledgyielstsdsgspifkspqtymdgllhyvsvisdnsgirllid 1201 dqllrnskrlkhisssrqslriggsnfegcisnvfvqrlslspeviditsnslkrdvslg 1261 gcslnkppflmllkgstrfnktktfrinqllqdtpvasprsvkvwqdacsplpktqanhg 1321 alqfgdiptshilfklpqellkprsqfavdmqttssrglvfhtgtknsfmalylskgrlv 1381 falgtdgkklrikskekcndgkwhtvvfghdgekgrlvvdglraregslpgnstisirap 1441 vylgsppsgkpkslptnsfvgclknfqldskplytpsssfgvssclggplekgiyfseeg 1501 ghvvlahsvllgpefklvfsirprsltgilihigsqpgkhlcvyleagkvtasmdsgagg 1561 tstsvtpkqslcdgqwhsvavtikqhilhleldtdssytagqipfppastqeplhlggap 1621 anlttlripvwksffgclrnihvnhipvpvtealevqgpvslngcpdq GeneID: Y16 Genesymbol: CD40 Genedescription: CD40molecule Unigene: Hs.472860 Genbank: AB209660 EntrezGene: 958 Refseq: NM_001250|NM_152854 Proteinsequenceisoform1(SEQIDNO(83)): 1 mvrlplqcvlwgclltavhpepptacrekqylinsqccslcqpgqklvsdcteftetecl 61 pcgesefldtwnrethchqhkycdpnlglrvqqkgtsetdtictceegwhctseacescv 121 lhrscspgfgvkqiatgvsdticepcpvgffsnvssafekchpwtscetkdlvvqqagtn 181 ktdvvcgpqdrlralvvipiifgilfaillvlvfikkvakkptnkaphpkqepqeinfpd 241 dlpgsntaapvqetlhgcqpvtqedgkesrisvqerq Proteinsequenceisoform2(SEQIDNO(84)): 1 mvrlplqcvlwgclltavhpepptacrekqylinsqccslcqpgqklvsdcteftetecl 61 pcgesefldtwnrethchqhkycdpnlglrvqqkgtsetdtictceegwhctseacescv 121 lhrscspgfgvkqiatgvsdticepcpvgffsnvssafekchpwtrspgsaespggdphh 181 lrdpvchplgaglyqkggqeanq GeneID: Y17 Genesymbol: COL17A1 Genedescription: collagen,typeXVII,alpha1 Unigene: Hs.117938 Genbank: AL138761 EntrezGene: 1308 Refseq: NM_000494 Proteinsequence(SEQIDNO(85)): 1 mdvtkknkrdgtevterivtetvttrltslppkggtsngyaktaslgggsrlekqslthg 61 ssgyinstgstrghastssyrrahspastlpnspgstferkthvtrhayegsssgnsspe 121 yprkefassstrgrsqtreseirvrlqsaspstrwtelddvkrllkgsrsasvsptrnss 181 ntlpipkkgtvetkivtassqsvsgtydatildanlpshvwsstlpagssmgtyhnnmtt 241 qsssllntnaysagsvfgvpnnmascsptlhpglstsssvfgmqnnlapslttlshgttt 301 tstaygvkknmpqspaavntgvstsaacttsvqsddllhkdckflilekdntpakkemel 361 limtkdsgkvftaspasiaatsfsedtikkekqaaynadsglkaeangdlktvstkgktt 421 tadihsygssggggsgggggvggagggpwgpapawcpcgsccswwkwllgllltwilllg 481 llfglialaeevrklkarvdelerirrsilpygdsmdriekdrlqgmapaagadldkigl 541 hsdsqeelwmfvrkkimmeqengnirgspgpkgdmgspgpkgdrgfpgtpgipgplghpg 601 pqgpkgqkgsvgdpgmegpmgqrgregpmgprgeagppgsgekgergaagepgphgppgv 661 pgsvgpkgssgspgpqgppgpvglqgirgevglpgvkgdkgpmgppgpkgdqgekgprgl 721 tgepgmrglpgavgepgakgamgpagpdghqgprgeqgltgmpgirgppgpsgdpgkpgl 781 tgpqgpqglpgtpgrpgikgepgapgkivtsegssmltvpgppgppgamgppgppgapgp 841 agpaglpghqeviniqgppgppgprgppgpsipgppgprgppgeglpgppgppgsflsns 901 etflsgppgppgppgpkgdqgppgprghqgeqglpgfstsgsssfginiqgppgppgpqg 961 pkgdkgdpgvpgalgipsgpseggssstmyvsgppgppgppgppgsisssgqeiqqyise 1021 ymqsdsirsylsgvqgppgppgppgpvttitgetfdyselashvvsylrtsgygvslfss 1081 sissedilavlqrddvrqylrqylmgprgppgppgasgdgsllsldyaelssrilsymss 1141 sgisiglpgppgppglpgtsyeellsllrgsefrgivgppgppgppgipgnvwssisved 1201 lssylhtaglsfipgppgppgppgprgppgvsgalatyaaensdsfrselisyltspdvr 1261 sfivgppgppgpqgppgdsrllstdashsrgssssshsssvrrgssysssmstggggags 1321 lgaggafgeaagdrgpygtdigpgggygaaaeggmyagnggllgadfagdldynelavrv 1381 sesmqrqgllqgmaytvqgppgqpgpqgppgiskvfsaysnvtadlmdffqtygaiqgpp 1441 gqkgemgtpgpkgdrgpagppghpgppgprghkgekgdkgdqvyagrrrrrsiavkp GeneID: Y18 Genesymbol: DSC2 Genedescription: Desmocollin-2 Unigene: Hs.95612 Genbank: BC063291 EntrezGene: 1824 Refseq: NM_024422|NM_004949 ProteinsequenceisoformDsc2a(SEQIDNO(86)): 1 meaarpsgswngalcrlllltlailifasdacknvtlhvpskldaeklvgrvnlkecfta 61 anlihssdpdfqiledgsvyttntillssekrsftillsntenqekkkifvflehqtkvl 121 kkrhtkekvlrrakrrwapipcsmlenslgpfplflqqvqsdtaqnytiyysirgpgvdq 181 eprnlfyverdtgnlyctrpvdreqyesfeiiafattpdgytpelplpliikiedendny 241 pifteetytftifencrvgttvgqvcatdkdepdtmhtrlkysiigqvppsptlfsmhpt 301 tgvitttssqldrelidkyqlkikvqdmdgqyfglqttstciiniddvndhlptftrtsy 361 vtsveentvdveilrvtvedkdlvntanwranytilkgnengnfkivtdaktnegvlcvv 421 kplnyeekqqmilqigvvneapfsreasprsamstatvtvnvedqdegpecnppiqtvrm 481 kenaevgttsngykaydpetrsssgirykkltdptgwvtidentgsikvfrsldreaeti 541 kngiynitvlasdqggrtctgtlgiilqdvndnspfipkktviickptmssaeivavdpd 601 epihgppfdfslesstsevqrmwrlkaindtaarlsyqndppfgsyvvpitvrdrlgmss 661 vtsldvtlcdcitendcthrvdpriggggvqlgkwailaillgiallfcilftlvcgasg 721 tskqpkvipddlaqqnlivsnteapgddkvysangfttqtvgasaqgvcgtvgsgikngg 781 qetiemvkgghqtsescrgaghhhtldscrgghtevdncrytysewhsftqprlgekvyl 841 cnqdenhkhaqdyvltynyegrgsvagsvgccserqeedglefldnlepkfrtlaeacmk 901 r ProteinsequenceisoformDsc2b(SEQIDNO(87)): 1 meaarpsgswngalcrlllltlailifasdacknvtlhvpskldaeklvgrvnlkecfta 61 anlihssdpdfqiledgsvyttntillssekrsftillsntenqekkkifvflehqtkvl 121 kkrhtkekvlrrakrrwapipcsmlenslgpfplflqqvqsdtaqnytiyysirgpgvdq 181 eprnlfyverdtgnlyctrpvdreqyesfeiiafattpdgytpelplpliikiedendny 241 pifteetytftifencrvgttvgqvcatdkdepdtmhtrlkysiigqvppsptlfsmhpt 301 tgvitttssqldrelidkyqlkikvqdmdgqyfglqttstciiniddvndhlptftrtsy 361 vtsveentvdveilrvtvedkdlvntanwranytilkgnengnfkivtdaktnegvlcwv 421 kplnyeekqqmilqigvvneapfsreasprsamstatvtvnvedqdegpecnppiqtvrm 481 kenaevgttsngykaydpetrsssgirykkltdptgwvtidentgsikvfrsldreaeti 541 kngiynitvlasdqggrtctgtlgiilqdvndnspfipkktviickptmssaeivavdpd 601 epihgppfdfslesstsevqrmwrlkaindtaarlsyqndppfgsyvvpitvrdilgmss 661 vtsldvtlcdcitendcthrvdpriggggvqlgkwailaillgiallfcilftlvcgasg 721 tskqpkvipddlaqqnlivsnteapgddkvysangfttqtvgasaqgvcgtvgsgikngg 781 qetiemvkgghqtsescrgaghhhtldscrgghtevdncrytysewhsftqprlgeesir 841 ghtlikn GeneID: Y19 Genesymbol: DSC1 Genedescription: Desmocollin-1 Unigene: Hs.567260 Genbank: X72925 EntrezGene: 1823 Refseq: NM_024421|NM_004948 ProteinsequenceisoformDsc1a(SEQIDNO(88)): 1 malasaapgsifckqllfsllvltllcdacqkvylrvpshlqaetlvgkvnleeclksas 61 lirssdpafriledgsiytthdlilsserksfsiflsdgqrreqqeikvvlsarenkspk 121 krhtkdtalkrskrrwapipaslmenslgpfpqhvqqiqsdaaqnytifysisgpgvdke 181 pfnlfyiekdtgdifctrsidrekyeqfalygyattadgyapeyplpliikieddndnap 241 yfehrvtiftvpencrsgtsvgkvtatdldepdtlhtrlkykilqqipdhpkhfsihpdt 301 gvittttpfldrekcdtyqlimevrdmggqpfglfntgtitisledendnppsftetsyv 361 teveenridveilrmkvqdqdlpntphskavykilqgnengnfiistdpntnegvlcvvk 421 plnyevnrqvilqvgvineaqfskaassqtptmctttvtvkiidsdegpechppvkviqs 481 qdgfpagqellgykaldpeissgeglryqklgdednwfeinqhtgdlrtlkvldreskfv 541 knnqynisvvavdavgrsctgtlvvhlddyndhapqidkevticqnnedfavlkpvdpdg 601 pengppfqffldnsasknwnieekdgktailrqrqnldynyysvpiqikdrhglvathml 661 tvrvcdcstpsecrmkdkstrdvrpnvilgrwailamvigsvlllcilftcfcvtakrtv 721 kkcfpediaqqnlivsntegpgeevteanirlpmqtsnicdtsmsvgtvggqgiktqqsf 781 emvkggytldsnkggghqtlesvkgvgqgdtgryaytdwqsftqprigekvylcgqdeeh 841 khcedyvcsynyegkgslagsvgccsdrqeeeglefldhlepkfrtlaktcikk ProteinsequenceisoformDsc1b(SEQIDNO(89)): 1 malasaapgsifckqllfsllvltllcdacqkvylrvpshlqaetlvgkvnleeclksas 61 lirssdpafriledgsiytthdlilsserksfsiflsdgqrreqqeikvvlsarenkspk 121 krhtkdtalkrskrrwapipaslmenslgpfpqhvqqiqsdaaqnytifysisgpgvdke 181 pfnlfyiekdtgdifctrsidrekyeqfalygyattadgyapeyplpliikieddndnap 241 yfehrvtiftvpencrsgtsvgkvtatdldepdtlhtrikykilqqipdhpkhfsihpdt 301 gvittttpfldrekcdtyqlimevrdmggqpfglfntgtitisledendnppsftetsyv 361 teveenridveilrmkvqdqdlpntphskavykilqgnengnfiistdpntnegvlcvvk 421 plnyevnrqvilqvgvineaqfskaassqtptmctttvtvkiidsdegpechppvkviqs 481 qdgfpagqellgykaldpeissgeglryqklgdednwfeinqhtgdirtlkvldreskfv 541 knnqynisvvavdavgrsctgtlvvhiddyndhapqidkevticqnnedfavlkpvdpdg 601 pengppfqffldnsasknwnieekdgktailrqrqnldynyysvpiqikdrhglvathml 661 tvrvcdcstpsecrmkdkstrdvrpnvilgrwailamvlgsvlllcilftcfcvtakrtv 721 kkcfpediaqqnlivsntegpgeevteanirlpmqtsnicdtsmsvgtvggqgiktqqsf 781 emvkggytldsnkggghqtlesvkgvgqgdtgryaytdwqsftqprlgeesirghtlikn GeneID: Y20 Genesymbol: ITGA6 Genedescription: Integrinalpha-6 Unigene: Hs.133397 Genbank: X59512 EntrezGene: 3655 Refseq: NM_000210|NM_001079818 Proteinsequenceisoformb(SEQIDNO(90)): 1 maaagqlcllylsagllsrlgaafnldtrednvirkygdpgslfgfslamhwqlqpedkr 61 lllvgapraealplqranrtgglyscditargpctriefdndadptseskedqwmgvtvq 121 sqgpggkvvtcahryekrqhvntkqesrdifgrcyvlsqnlrieddmdggdwsfcdgrlr 181 ghekfgscqqgvaatftkdfhyivfgapgtynwkgivrveqknntffdmnifedgpyevg 241 getehdeslvpvpansylgfsldsgkgivskdeitfvsgapranhsgavvllkrdmksah 301 llpehifdgeglassfgydvavvdinkdgwqdivigapqyfdrdgevggavyvymnqqgr 361 wnnvkpirlngtkdsmfgiavknigdinqdgypdiavgapyddlgkvfiyhgsangintk 421 ptqvlkgispyfgysiagnmdldrnsypdvavgslsdsvtifrsrpviniqktitvtpnr 481 idlrqktacgapsgiclqvkscfeytanpagynpsisivgtleaekerrksglssrvqfr 541 nqgsepkytqeltlkrqkqkvcmeetlwlqdnirdklrpipitasveiqepssrrrvnsl 601 pevlpilnsdepktahidvhflkegcgddnvcnsnlkleykfctregnqdkfsylpiqkg 661 vpelvikdqkdialeitvtnspsnprnptkdgddaheakliatfpdtltysayrelrafp 721 ekqlscvanqngsqadcelgnpfkrnsnvtfylvisttevtfdtpdldinlklettsnqd 781 nlapitakakvvielllsvsgvakpsqvyfggtvvgeqamksedevgslieyefrvinlg 841 kpltnlgtatlniqwpkeisngkwllylvkveskglekvtcepqkeinslnlteshnsrk 901 kreitekqiddnrkfslfaerkyqtlncsvnvncvnircplrgldskaslilrsrlwnst 961 fleeysklnyldilmrafidvtaaaenirlpnagtqvrvtvfpsktvagysgvpwwiilv 1021 ailagilmlallvfilwkcgffkrnkkdhydatyhkaeihaqpsdkerltsda Proteinsequenceisoforma(SEQIDNO(91)): 1 maaagqlcllylsagllsrlgaafnldtrednvirkygdpgslfgfslamhwqlqpedkr 61 lllvgapraealplqranrtgglyscditargpctriefdndadptseskedqwmgvtvq 121 sqgpggkvvtcahryekrqhvntkqesrdifgrcyvlsqnlrieddmdggdwsfcdgnlr 181 ghekfgscqqgvaatftkdfhyivfgapgtynwkgivrveqknntffdmnifedgpyevg 241 getehdeslvpvpansylgfsldsgkgivskdeitfvsgapranhsgavvllkrdmksah 301 llpehifdgeglassfgydvavvdlnkdgwqdivigapqyfdrdgevggavyvymnqqgr 361 wnnvkpirlngtkdsmfgiavknigdinqdgypdiavgapyddlgkvfiyhgsangintk 421 ptqvlkgispyfgysiagnmdldrnsypdvavgslsdsvtifrsrpviniqktitvtpnr 481 idlrqktacgapsgiclqvkscfeytanpagynpsisivgtleaekerrksglssrvqfr 541 nqgsepkytqeltlkrqkqkvcmeetlwlqdnirdkirpipitasveiqepssrrrvnsl 601 pevlpilnsdepktahidvhflkegcgddnvcnsnlkleykfctregnqdkfsylpiqkg 661 vpelvikdqkdialeitvtnspsnprnptkdgddaheakliatfpdtltysayrelrafp 721 ekqlscvanqngsqadcelgnpfkrnsnvtfylvlsttevtfdtpdldinlklettsnqd 781 nlapitakakvvielllsvsgvakpsqvyfggtvvgeqamksedevgslieyefrvinlg 841 kpltnigtatlniqwpkeisngkwllylvkveskglekvtcepqkeinslnlteshnsrk 901 kreitekqiddnrkfslfaerkyqtlncsvnvncvnircplrgldskaslilrsrlwnst 961 fleeysklnyldilmrafidvtaaaenirlpnagtqvrvtvfpsktvagysgvpwwiilv 1021 ailagilmlallvfilwkcgffkrsryddsvpryhavrirkeereikdekyidnlekkqw 1081 itkwnenesys GeneID: Y21 Genesymbol: ITGB4 Genedescription: Integrinbeta-4 Unigene: Hs.632226 Genbank: X53587|X51841|X52186 EntrezGene: 3691 Refseq: NM_000213|NM_001005619|NM_001005731 Proteinsequenceisoform1(SEQIDNO(92)): 1 magprpspwarlllaalisvslsgtlanrckkapvksctecvrvdkdcayctdemfrdrr 61 cntqaellaagcqresivvmessfqiteetqidttlrrsqmspqglrvrlrpgeerhfel 121 evfeplespvdlyilmdfsnsmsddldnikkmgqnlarvlsqltsdytigfgkfvdkvsv 181 pqtdmrpeklkepwpnsdppfsfknvisitedvdefrnklqgerisgnldapeggfdail 241 qtavctrdigwrpdsthllvfstesafhyeadganvlagimsrnderchldttgtytqyr 301 tqdypsvptlvrllakhniipifavtnysysyyeklhtyfpvsslgvlqedssnivelle 361 eafnrirsnldiraldsprglrtevtskmfqktrtgsfhirrgevgiyqvqlralehvdg 421 thvcqlpedqkgnihlkpsfsdglkmdagiicdvctcelqkevrsarcsfngdfvegqcv 481 csegwsgqtcncstgslsdiqpclregedkpcsgrgecqcghcvcygegryegqfceydn 541 fqcprtsgflcndrgresmgqcvcepgwtgpscdcplsnatcidsnggicngrghcecgr 601 chchqqslytdticeinysaihpglcedlrscvqcqawgtgekkgrtceecnfkvkmvde 661 lkraeevvvrcsfrdedddctysytmegdgapgpnstvlvhkkkdcppgsfwwlipllll 721 llpllalllllcwkycacckaclallpccnrghmvgfkedhymlrenlmasdhldtpmlr 781 sgnlkgrdvvrwkvtnnmqrpgfathaasinptelvpyglslrlarlctenllkpdtrec 841 aqlrqeveenlnevyrqisgvhklqqtkfrqqpnagkkqdhtivdtvlmaprsakpallk 901 ltekqveqrafhdlkvapgyytltadqdargmvefqegvelvdvrvplfirpedddekql 961 lveaidvpagtatlgrrlvnitiikeqardvvsfeqpefsvsrgdqvaripvirrvldgg 1021 ksqvsyrtqdgtaqgnrdyipvegellfqpgeawkelqvkllelqevdsllrgrqvrrfh 1081 vqlsnpkfgahlgqphsttiiirdpdeldrsftsqmlssqppphgdlgapqnpnakaags 1141 rkihfnwlppsgkpmgyrvkywiqgdseseahlldskvpsveltnlypycdyemkvcayg 1201 aqgegpysslvscrthqevpsepgrlafnvvsstvtqlswaepaetngeitayevcyglv 1261 nddnrpigpmkkvlvdnpknrmllienlresqpyrytvkarngagwgpereaiinlatqp 1321 krpmsipiipdipivdaqsgedydsflmysddvirspsgsqrpsvsddtgcgwkfepllg 1381 eeldlrrvtwrlppeliprlsassgrssdaeaphgppddggaggkggslprsatpgppge 1441 hlvngrmdfafpgstnslhrmtttsaaaygthlsphvphrvlstsstltrdynsltrseh 1501 shsttlprdystltsvsshdsrltagvpdtptrlvfsalgptslrvswqeprcerplqgy 1561 sveyqllnggelhrlnipnpaqtsvvvedllpnhsyvfrvraqsqegwgreregvities 1621 qvhpqsplcplpgsaftlstpsapgplvftalspdslqlswerprrpngdivgylvtcem 1681 aqgggpatafrvdgdspesrltvpglsenvpykfkvqarttegfgperegiitiesqdgg 1741 pfpqlgsraglfqhplqseyssittthtsatepflvdgltlgaqhleaggsltrhvtqef 1801 vsrtlttsgtlsthmdqqffqt Proteinsequenceisoform2(SEQIDNO(93)): 1 magprpspwarlllaalisvslsgtlanrckkapvksctecvrvdkdcayctdemfrdrr 61 cntqaellaagcqresivvmessfqiteetqidttlrrsqmspqglrvrlrpgeerhfel 121 evfeplespvdlyilmdfsnsmsddldnikkmgqnlarvlsqltsdytigfgkfvdkvsv 181 pqtdmrpeklkepwpnsdppfsfknvisitedvdefrnklqgerisgnldapeggfdail 241 qtavctrdigwrpdsthllvfstesafhyeadganvlagimsrnderchldttgtytqyr 301 tqdypsvptlvrllakhniipifavtnysysyyeklhtyfpvsslgvlqedssnivelle 361 eafnrirsnldiraldsprglrtevtskmfqktrtgsfhirrgevgiyqvqlralehvdg 421 thvcqlpedqkgnihlkpsfsdglkmdagiicdvctcelqkevrsarcsfngdfvcgqcv 481 csegwsgqtcncstgslsdiqpclregedkpcsgrgecqcghcvcygegryegqfceydn 541 fqcprtsgflcndrgresmgqcvcepgwtgpscdcplsnatcidsnggicngrghcecgr 601 chchqqslytdticeinysaihpglcedirscvqcqawgtgekkgrtceecnfkvkmvde 661 lkraeevvvrcsfrdedddctysytmegdgapgpnstvlvhkkkdcppgsfwwlipllll 721 llpllalllllcwkycacckaclallpccnrghmvgfkedhymlrenlmasdhldtpmlr 781 sgnlkgrdvvrwkvtnnmqrpgfathaasinptelvpyglsirlarictenllkpdtrec 841 aqlrqeveenlnevyrqisgvhklqqtkfrqqpnagkkqdhtivdtvlmaprsakpallk 901 ltekqveqrafhdlkvapgyytltadqdargmvefqegvelvdvrvplfirpedddekql 961 lveaidvpagtatlgrrlvnitiikeqardvvsfeqpefsvsrgdqvaripvirrvldgg 1021 ksqvsyrtqdgtaqgnrdyipvegellfqpgeawkelqvkllelqevdsllrgrqvrrfh 1081 vqlsnpkfgahlgqphsttiiirdpdeldrsftsqmissqppphgdlgapqnpnakaags 1141 rkihfnwlppsgkpmgyrvkywiqgdseseahlldskvpsveltnlypycdyemkvcayg 1201 aqgegpysslvscrthqevpsepgrlafnvvsstvtqlswaepaetngeitayevcyglv 1261 nddnrpigpmkkvlvdnpknrmllienlresqpyrytvkarngagwgpereaiinlatqp 1321 krpmsipiipdipivdaqsgedydsflmysddvlrspsgsqrpsvsddtehlvngrmdfa 1381 fpgstnslhrmtttsaaaygthisphvphrvistsstltrdynsltrsehshsttlprdy 1441 stltsvsshglppiwehgrsrlplswalgsrsraqmkgfppsrgprdsiilagrpaapsw 1501 gpdsrltagvpdtptrlvfsalgptsirvswqeprcerplqgysveyqllnggelhrlni 1561 pnpaqtsvvvedllpnhsyvfrvraqsqegwgreregvitiesqvhpqsplcplpgsaft 1621 lstpsapgplvftalspdslqlswerprrpngdivgylvtcemaqgggpatafrvdgdsp 1681 esrltvpglsenvpykfkvqarttegfgperegiitiesqdggpfpqlgsraglfqhplq 1741 seyssittthtsatepflvdgltlgaqhleaggsltrhvtqefvsrtlttsgtlsthmdq 1801 qffqt Proteinsequenceisoform3(SEQIDNO(94)): 1 magprpspwarlllaalisvslsgtlanrckkapvksctecvrvdkdcayctdemfrdrr 61 cntqaellaagcqresivvmessfqiteetqidttlrrsqmspqglrvrlrpgeerhfel 121 evfeplespvdlyilmdfsnsmsddldnlkkmgqnlarvlsqltsdytigfgkfvdkvsv 181 pqtdmrpeklkepwpnsdppfsfknvisltedvdefrnklqgerisgnldapeggfdail 241 qtavctrdigwrpdsthllvfstesafhyeadganvlagimsrnderchldttgtytqyr 301 tqdypsvptlvrllakhniipifavtnysysyyeklhtyfpvsslgvlqedssnivelle 361 eafnrirsnldiraldsprglrtevtskmfqktrtgsfhirrgevgiyqvqlralehvdg 421 thvcqlpedqkgnihlkpsfsdglkmdagiicdvctcelqkevrsarcsfngdfvcgqcv 481 csegwsgqtcncstgslsdiqpclregedkpcsgrgecqcghcvcygegryegqfceydn 541 fqcprtsgflcndrgresmgqcvcepgwtgpscdcplsnatcidsnggicngrghcecgr 601 chchqqslytdticeinysaihpglcedirscvqcqawgtgekkgrtceecnfkvkmvde 661 lkraeevvvrcsfrdedddctysytmegdgapgpnstvlvhkkkdcppgsfwwlipllll 721 llpllalllllcwkycacckaclallpccnrghmvgfkedhymlrenlmasdhldtpmlr 781 sgnlkgrdvvrwkvtnnmqrpgfathaasinptelvpyglslrlarlctenllkpdtrec 841 aqlrqeveenlnevyrqisgvhklqqtkfrqqpnagkkqdhtivdtvlmaprsakpallk 901 ltekqveqrafhdlkvapgyytltadqdargmvefqegvelvdvrvplfirpedddekql 961 lveaidvpagtatlgrrlvnitiikeqardvvsfeqpefsvsrgdqvaripvirrvldgg 1021 ksqvsyrtqdgtaqgnrdyipvegellfqpgeawkelqvkllelqevdsllrgrqvrrfh 1081 vqlsnpkfgahlgqphsttiiirdpdeldrsftsqmlssqppphgdlgapqnpnakaags 1141 rkihfnwlppsgkpmgyrvkywiqgdseseahlldskvpsveltnlypycdyemkvcayg 1201 aqgegpysslvscrthqevpsepgrlafnvvsstvtqlswaepaetngeitayevcyglv 1261 nddnrpigpmkkvlvdnpknrmllienlresqpyrytvkarngagwgpereaiinlatqp 1321 krpmsipiipdipivdaqsgedydsflmysddvlrspsgsqrpsvsddtehlvngrmdfa 1381 fpgstnslhrmtttsaaaygthlsphvphrvlstsstltrdynsltrsehshsttlprdy 1441 stltsvsshdsrltagvpdtptrlvfsalgptslrvswqeprcerplqgysveyqllngg 1501 elhrlnipnpaqtsvvvedllpnhsyvfrvraqsqegwgreregvitiesqvhpqsplcp 1561 lpgsaftlstpsapgplvftalspdslqlswerprrpngdivgylvtcemaqgggpataf 1621 rvdgdspesrltvpglsenvpykfkvqarttegfgperegiitiesqdggpfpqlgsrag 1681 lfqhplqseyssittthtsatepflvdgltlgaqhleaggsltrhvtqefvsrtlttsgt 1741 lsthmdqqffqt GeneID: Y22 Genesymbol: PVRL4 Genedescription: Poliovirusreceptor-relatedprotein4 Unigene: Hs.492490 Genbank: BC010423 EntrezGene: 81607 Refseq: NM_030916 Proteinsequence(SEQIDNO(95)): 1 mplslgaemwgpeawlllllllasftgrcpageletsdvvtvvlgqdaklpcfyrgdsge 61 qvgqvawarvdagegaqelallhskyglhvspayegrveqpppprnpldgsvllrnavqa 121 degeyecrvstfpagsfqarlrlrvlvpplpslnpgpaleegqgltlaasctaegspaps 181 vtwdtevkgttssrsfkhsrsaavtsefhlvpsrsmngqpltcvvshpgllqdqrithil 241 hvsflaeasvrgledqnlwhigregamlkclsegqpppsynwtrldgplpsgvrvdgdtl 301 gfpplttehsgiyvchvsnefssrdsqvtvdvldpqedsgkqvdlvsasvvvvgviaall 361 fcllvvvvvlmsryhrrkaqqmtqkyeeeltltrensirrlhshhtdprsqpeesvglra 421 eghpdslkdnsscsvmseepegrsystlttvreietqtellspgsgraeeeedqdegikq 481 amnhfvqengtlrakptgngiyingrghlv GeneID: Y23 Genesymbol: SDC1 Genedescription: Syndecan-1 Unigene: Hs.224607 Genbank: BC008765 EntrezGene: 6382 Refseq: NM_001006946 Proteinsequence(SEQIDNO(96)): 1 mrraalwlwlcalalslqpalpqivatnlppedqdgsgddsdnfsgsgagalqditlsqq 61 tpstwkdtqlltaiptspeptgleataaststlpagegpkegeavvlpevepgltareqe 121 atprprettqlptthqastttattaqepatshphrdmqpghhetstpagpsqadlhtpht 181 edggpsateraaedgassqlpaaegsgeqdftfetsgentavvavepdrrnqspvdqgat 241 gasqglldrkevlggviagglvglifavclvgfmlyrmkkkdegsysleepkqanggayq 301 kptkqeefya GeneID: Z1 Genesymbol: ENPP1 Genedescription: Ectonucleotidepyrophosphatase/phosphodiesterasefamilymember1 Unigene: Hs.527295 Genbank: BC059375 EntrezGene: 5167 Refseq: NM_006208 Proteinsequence(SEQIDNO(97)): 1 merdgcagggsrggeggrapregpagngrdrgrshaaeapgdpqaaasllapmdvgeepl 61 ekaarartakdpntykvlslvlsvcvlttilgcifglkpscakevksckgrcfertfgnc 121 rcdaacvelgnccldyqetciepehiwtenkfrcgekrltrslcacsddckdkgdcciny 181 ssvcqgekswveepcesinepqcpagfetpptllfsldgfraeylhtwggllpvisklkk 241 cgtytknmrpvyptktfpnhysivtglypeshgiidnkmydpkmnasfslkskekfnpew 301 ykgepiwvtakyqglksgtffwpgsdveingifpdiykmyngsvpfeerilavlqwlqlp 361 kderphfytlyleepdssghsygpvssevikalqrvdgmvgmlmdglkelnlhrclnlil 421 isdhgmeqgsckkyiylnkylgdvknikviygpaarlrpsdvpdkyysfnyegiarnlsc 481 repnqhfkpylkhflpkrlhfaksdriepltfyldpqwqlalnpserkycgsgfhgsdnv 541 fsnmqalfvgygpgfkhgieadtfenievynlmcdllnltpapnngthgslnhllknpvy 601 tpkhpkevhplvqcpftrnprdnlgcscnpsilpiedfqtqfnltvaeekiikhetlpyg 661 rprvlqkenticllsqhqfmsgysqdilmplwtsytvdrndsfstedfsnclyqdfripl 721 spvhkcsfyknntkvsygflsppqlnknssgiyseallttnivpmyqsfqviwryfhdtl 781 lrkyaeerngvnvvsgpvfdfdydgrcdslenlrqkrrvirnqeilipthffivltsckd 841 tsqtplhcenldtlafilphrtdnsescvhgkhdsswveellmlhraritdvehitglsf 901 yqqrkepvsdilklkthlptfsqed GeneID: Z2 Genesymbol: CD34 Genedescription: HematopoieticprogenitorcellantigenCD34 Unigene: Hs.374990 Genbank: M81104 EntrezGene: 947 Refseq: NM_001773|NM_001025109 Proteinsequenceisoformb(SEQIDNO(98)): 1 mlvrrgaragprmprgwtalcllsllpsgfmsldnngtatpelptqgtfsnvstnvsyqe 61 tttpstlgstslhpvsqhgneattnitettvkftstsvitsvygntnssvqsqtsvistv 121 fttpanvstpettlkpslspgnvsdlsttstslatsptkpytssspilsdikaeikcsgi 181 revkltqgicleqnktsscaefkkdrgeglarvlcgeeqadadagaqvcslllaqsevrp 241 qclllvlanrteissklqlmkkhqsdlkklgildfteqdvashqsysqktlialvtsgal 301 lavlgitgyflmnrrswsptgerlelep Proteinsequenceisoforma(SEQIDNO(99)): 1 mlvrrgaragprmprgwtalcllsllpsgfmsldnngtatpelptqgtfsnvstnvsyqe 61 tttpstlgstslhpvsqhgneattnitettvkftstsvitsvygntnssvqsqtsvistv 121 fttpanvstpettlkpslspgnvsdlsttstslatsptkpytssspilsdikaeikcsgi 181 revkltqgicleqnktsscaefkkdrgeglarvlcgeeqadadagaqvcslllaqsevrp 241 qclllvlanrteissklqlmkkhqsdlkklgildfteqdvashqsysqktlialvtsgal 301 lavlgitgyflmnrrswsptgerlgedpyytengggqgyssgpgtspeaqgkasvnrgaq 361 engtgqatsrnghsarqhvvadtel GeneID: Z3 Genesymbol: JAM3 Genedescription: JunctionaladhesionmoleculeC Unigene: Hs.150718 Genbank: BC012147 EntrezGene: 83700 Refseq: NM_032801|NM_001205329 Proteinsequenceisoform1(SEQIDNO(100)): 1 malrrpprlrlcarlpdffllllfrgcligavnlkssnrtpvvqefesvelsciitdsqt 61 sdpriewkkiqdeqttyvffdnkiqgdlagraeilgktslkiwnvtrrdsalyrcevvar 121 ndrkeideivieltvqvkpvtpvcrvpkavpvgkmatlhcqeseghprphyswyrndvpl 181 ptdsranprfrnssfhlnsetgtlvftavhkddsgqyyciasndagsarceeqemevydl 241 niggiiggvlvvlavlalitlgiccayrrgyfinnkqdgesyknpgkpdgvnyirtdeeg 301 dfrhkssfvi Proteinsequenceisoform2(SEQIDNO(101)): 1 malrrpprlrlcarlpdffllllfrgcligavnlkssnrtpvvqefesvelsciitdsqt 61 sdpriewkkiqdeqttyvffdnkiqvkpvtpvcrvpkavpvgkmatlhcqeseghprphy 121 swyrndvplptdsranprfrnssfhlnsetgtlvftavhkddsgqyyciasndagsarce 181 eqemevydlniggiiggvlvvlavlalitlgiccayrrgyfinnkqdgesyknpgkpdgv 241 nyirtdeegdfrhkssfvi GeneID: Z4 Genesymbol: CD14 Genedescription: MonocytedifferentiationantigenCD14 Unigene: Hs.163867 Genbank: BC010507 EntrezGene: 929 Refseq: NM_000591 Proteinsequence(SEQIDNO(102)): 1 merascllllllplvhvsattpepcelddedfrcvcnfsepqpdwseafqcvsaveveih 61 agglnlepflkrvdadadprqyadtvkalrvrrltvgaaqvpaqllvgalrvlaysrlke 121 ltledlkitgtmpplpleatglalsslrlrnvswatgrswlaelqqwlkpglkvlsiaqa 181 hspafsceqvrafpaltsldlsdnpglgerglmaalcphkfpaiqnlalrntgmetptgv 241 caalaaagvqphsldlshnslratvnpsaprcmwssalnslnlsfagleqvpkglpaklr 301 vldlscnrlnrapqpdelpevdnltldgnpflvpgtalphegsmnsgvvpacarstlsvg 361 vsgtlvllqgargfa GeneID: Z5 Genesymbol: PLSCR4 Genedescription: Phospholipidscramblase4 Unigene: Hs.477869 Genbank: AF199023 EntrezGene: 57088 Refseq: NM_001128304|NM_001128306|NM_001177304 Proteinsequenceisoforma(SEQIDNO(103)): 1 msgvvptapeqpagemenqtkppdprpdappeynshflpgppgtavppptgypgglpmgy 61 yspqqpstfplyqpvggihpvryqpgkypmpnqsvpitwmpgptpmancppgleylvqld 121 nihvlqhfeplemmtcfetnnrydiknnsdqmvyivtedtddftrnayrtlrpfvlrvtd 181 cmgreimtmqrpfrctcccfccpsarqelevqcppgvtigfvaehwnlcravysiqnekk 241 envmrvrgpcstygcgsdsvfevksldgisnigsiirkwngllsamadadhfdihfpldl 301 dvkmkamifgacflidfmyfersppqrsr Proteinsequenceisoformb(SEQIDNO(104)): 1 msgvvptapeqpagemenqtkppdprpdappeynshflpgppgtavppptgypgglpmgy 61 yspqqpstfplyqpvggihpvryqpgkypmpnqsvpitwmpgptpmancppgleylvqle 121 vqcppgvtigfvaehwnlcravysiqnekkenvmrvrgpcstygcgsdsvfevksldgis 181 nigsiirkwngllsamadadhfdihfpldldvkmkamifgacflidfmyfersppqrsr Proteinsequenceisoformc(SEQIDNO(105)): 1 menqtkppdprpdappeynshflpgppgtavppptgypgglpmgyyspqqpstfplyqpv 61 ggihpvryqpgkypmpnqsvpitwmpgptpmancppgleylvqlevqcppgvtigfvaeh 121 wnlcravysiqnekkenvmrvrgpcstygcgsdsvfevksldgisnigsiirkwngllsa 181 madadhfdihfpldldvkmkamifgacflidfmyfersppqrsr GeneID: Z6 Genesymbol: AMOT Genedescription: angiomotin Unigene: Hs.528051 Genbank: AF286598 EntrezGene: 154796 Refseq: NM_133265|NM_001113490 Proteinsequenceisoform2(SEQIDNO(106)): 1 mpraqpssasyqpvpadpfaivsraqqmveilsdenrnlrqelegcyekvarlqkvetei 61 qrvseayenlvkssskrealekamrnklegeirrmhdfnrdirerletankqlaekeyeg 121 sedtrktisqlfaknkesqrekekleaelatarstnedqrrhieirdqalsnaqakvvkl 181 eeelkkkqvyvdkvekmqqalvqlqaacekreqlehrlrtrlereleslriqqrqgncqp 241 tnvseynaaalmellrekeerilaleadmtkweqkyleenvmrhfaldaaatvaaqrdtt 301 vishspntsydtaleariqkeeeeilmankrcldmegriktlhaqiiekdamikvlqqrs 361 rkepskteqlscmrpakslmsisnagsgllshsstltgspimeekrddkswkgslgillg 421 gdyraeyvpstpspvppstpllsahsktgsrdcstqtergtesnktaavapisvpapvaa 481 aataaaitataatitttmvaaapvavaaaaapaaaaapspataaataaavspaaagqipa 541 aasvasaaavapsaaaaaavqvapaapapvpapalvpvpapaaaqasapaqtqaptsapa 601 vaptpaptptpavaqaevpaspatgpgphrlsipsltcnpdktdgpvfhsntlerktpiq 661 ilgqepdaemveyli Proteinsequenceisoform1(SEQIDNO(107)): 1 mrnseeqpsggttvlqrllqeqlrygnpsenrsllaihqqatgngppfpsgsgnpgpqsd 61 vlspqdhhqqlvahaarqepqgqeiqsenlimekqlsprmqnneelptyeeakvqsqyfr 121 gqqhasvgaafyvtgvtnqkmrtegrpsvqrlnpgkmhqdeglrdlkqghvrslserlmq 181 mslatsgvkahppvtsaplsppqpndlyknptsssefykaqgplpnqhslkgmehrgppp 241 eypfkgmppqsvvckpqepghfysehrlnqpgrtegqlmryqhppeygaarpaqdislpl 301 sarnsqphsptssltsggslpllqsppstrlsparhplvpnqgdhsahlprpqqhflpnq 361 ahqgdhyrlsqpglsqqqqqqqqqhhhhhhhqqqqqqqpqqqpgeaysampraqpssasy 421 qpvpadpfaivsraqqmveilsdenrnlrqelegcyekvarlqkveteiqrvseayenlv 481 kssskrealekamrnklegeirrmhdfnrdlrerletankqlaekeyegsedtrktisql 541 faknkesqrekekleaelatarstnedqrrhieirdqalsnaqakvvkleeelkkkqvyv 601 dkvekmqqalvqlqaacekreqlehrlrtrlereleslriqqrqgncqptnvseynaaal 661 mellrekeerilaleadmtkweqkyleenvmrhfaldaaatvaaqrdttvishspntsyd 721 taleariqkeeeeilmankrcldmegriktlhaqiiekdamikvlqqrsrkepskteqls 781 cmrpakslmsisnagsgllshsstltgspimeekrddkswkgslgillggdyraeyvpst 841 pspvppstpllsahsktgsrdcstqtergtesnktaavapisvpapvaaaataaaitata 901 atitttmvaaapvavaaaaapaaaaapspataaataaavspaaagqipaaasvasaaava 961 psaaaaaavqvapaapapvpapalvpvpapaaaqasapaqtqaptsapavaptpaptptp 1021 avaqaevpaspatgpgphrlsipsltcnpdktdgpvfhsntlerktpiqilgqepdaemv 1081 eyli GeneID: Z7 Genesymbol: ENPEP Genedescription: glutamylaminopeptidase(aminopeptidaseA) Unigene: Hs.435765 Genbank: L12468 EntrezGene: 2028 Refseq: NM_001977 Proteinsequence(SEQIDNO(108)): 1 mnfaeregskryciqtkhvailcavvvgvglivglavgltrscdssgdggpgtapapshl 61 psstaspsgppaqdqdicpasedesgqwknfrlpdfvnpvhydlhvkplleedtytgtvs 121 isinlsaptrylwlhlretritrlpelkrpsgdqvqvrrcfeykkqeyvvveaeeeltps 181 sgdglylltmefagwlngslvgfyrttytengqvksivatdheptdarksfpcfdepnkk 241 atytisithpkeygalsnmpvakeesvddkwtrttfeksvpmstylvcfavhqfdsvkri 301 snsgkpltiyvqpeqkhtaeyaanitksvfdyfeeyfamnyslpkldkiaipdfgtgame 361 nwglityretnllydpkesassnqqrvatvvahelvhqwfgnivtmdwwedlwlnegfas 421 ffeflgvnhaetdwqmrdqmlledvlpvqeddslmsshpiivtvttpdeitsvfdgisys 481 kgssilrmledwikpenfqkgcqmylekyqfknaktsdfwaaleeasrlpvkevmdtwtr 541 qmgypvlnvngvknitqkrflldpranpsqppsdlgytwnipvkwtednitssvlfnrse 601 kegitlnssnpsgnaflkinpdhigfyrvnyevatwdsiatalslnhktfssadraslid 661 dafalaraqlldykvalnltkylkreenflpwqrvisavtyiismfeddkelypmieeyf 721 qgqvkpiadslgwndagdhvtkllrssvlgfackmgdrealnnasslfeqwlngtvslpv 781 nlrllvyrygmqnsgneiswnytleqyqktslaqekekllyglasvknvtllsryldllk 841 dtnliktqdvftviryisynsygknmawnwiqlnwdylvnrytlnnrnlgrivtiaepfn 901 telqlwqmesffakypqagagekpreqvletvknniewlkqhrntirewffnllesg GeneID: Z8 Genesymbol: THY1 Genedescription: Thy-1cellsurfaceantigen Unigene: Hs.644697 Genbank: AP003396 EntrezGene: 7070 Refseq: NM_006288 Proteinsequence(SEQIDNO(109)): 1 mnlaisiallltvlqvsrgqkvtsltaclvdqslrldcrhentssspiqyefsltretkk 61 hvlfgtvgvpehtyrsrtnftskynmkvlylsaftskdegtytcalhhsghsppissqnv 121 tvlrdklvkcegisllaqntswllllllslsllqatdfmsl