KIT OF COSMETIC SKINCARE COMPOSITIONS

Abstract

According to the present invention there is provided a kit of cosmetic compositions, the kit comprising: 1) a cleansing composition, the cleansing composition comprising: (i) a cosmetically acceptable carrier; (ii) one or more surfactants; (iii) one or more anti-inflammatory agent; (iv) one or more antioxidant agent selected from polyphenolic antioxidant agents and antioxidant vitamins; (v) one or more skin-soothing agent; 2) a skin balancing composition, the skin balancing composition comprising: (i) a cosmetically acceptable carrier; (ii) Ophiopogon japonicas extract; (iii) one or more antioxidant agent selected from polyphenolic antioxidant agents and antioxidant vitamins; (iv) one or more sebum control agent selected from Rosa canina extract and sphingosine compounds; 3) a daytime protective composition, the daytime protective composition comprising: (i) a cosmetically acceptable carrier; (ii) one or more UV-filter; (iii) one or more antioxidant agent selected from polyphenolic antioxidant agents and antioxidant vitamins; (iv) one or more skin-soothing agent; and 4) an overnight treatment composition, the overnight treatment composition comprising: (i) a cosmetically acceptable carrier; (ii) one or more polyphenolic antioxidant agent; (iii) one or more antioxidant vitamin; (iv) one or more skin-soothing agent.

Claims

1. A kit of cosmetic compositions, the kit comprising: (1) a cleansing composition, the cleansing composition comprising: (i) a cosmetically acceptable carrier; (ii) one or more surfactants; (iii) one or more anti-inflammatory agents; and (iv) one or more antioxidant agents selected from polyphenolic antioxidant agents and antioxidant vitamins; (2) a skin balancing composition, the skin balancing composition comprising: (i) a cosmetically acceptable carrier; (ii) a skin-barrier enhancing agent selected from the group consisting of extracts of Ophiopogon (e.g. Ophiopogon japonicas), extracts of Aloe (e.g. Aloe vera), extracts of marshmallow (e.g. Althaea officianlis), extracts of Allium (e.g. Allium cepa), extracts of tuberose (e.g. Polianthes tuberosa), extracts of dandelion, extracts of seaweed (e.g. Laminaria digitate), ceramides, and combinations thereof; (iii) one or more antioxidant agents selected from polyphenolic antioxidant agents and antioxidant vitamins; and (iv) one or more sebum control agents selected from the group consisting of sphingosine compounds, Rosa canina extract, tea tree extract (e.g. Melaleuca alternifolia), witch hazel extract (e.g. Hamamelis virginiana), and combinations thereof; and (3) a daytime protective composition, the daytime protective composition comprising: (i) a cosmetically acceptable carrier; (ii) one or more UV-filters; (iii) one or more antioxidant agents selected from polyphenolic antioxidant agents and antioxidant vitamins; and (iv) one or more skin-soothing agents.

2. The kit of claim 1, wherein the kit further comprises (4) an overnight treatment composition, the overnight treatment composition comprising: (i) a cosmetically acceptable carrier; (ii) one or more polyphenolic antioxidant agents; (iii) one or more antioxidant vitamins; and (iv) one or more skin-soothing agents.

3. The kit of claim 1, wherein the cleansing composition further comprises (v) a skin-soothing agent.

4. The kit of claim 1, wherein the one or more sebum control agent (iv) in the skin balancing composition is selected from sphingosine compound, a Rosa canina extract and combinations thereof.

5. The kit of claim 1, wherein the kit further comprises (5) a skin improvement composition in the form of an intensive moisture product, an anti-shine product or an acne treatment product.

6. The kit of claim 5, wherein the intensive moisture product comprises: (i) a cosmetically acceptable carrier; (ii) a skin-barrier enhancing agent selected from the group consisting of extracts of Ophiopogon (e.g. O. japonicas), extracts of Aloe (e.g. Aloe vera), extracts of marshmallow (e.g. Althaea officianlis), extracts of Allium (e.g. Allium cepa), extracts of tuberose (e.g. Polianthes tuberosa), extracts of dandelion, extracts of seaweed (e.g. Laminaria digitate), ceramides, and combinations thereof; (iii) one or more antioxidant agents selected from polyphenolic antioxidant agents and antioxidant vitamins; (iv) one or more skin-soothing agents, the anti-shine product comprises: (i) a cosmetically acceptable carrier; (ii) one or more silicone agents; (iii) one or more antioxidant agents selected from polyphenolic antioxidant agents and antioxidant vitamins; (iv) one or more skin-soothing agents, the acne treatment product comprises: (i) a cosmetically acceptable carrier; (ii) one or more salicylic acid compounds; (iii) one or more antioxidant agents selected from polyphenolic antioxidant agents and antioxidant vitamins; (iv) one or more anti-inflammatory agents.

7. The kit of claim 1, wherein the skin-barrier enhancing agent (ii) in the skin balancing composition is an Ophiopogon japonicas extract and/or the kit of claim 6 wherein the skin-barrier enhancing agent (ii) in the intensive moisture product is an Ophiopogon japonicas extract.

8. The kit of claim 1, wherein in compositions (1) and (5), the anti-inflammatory agent: (i) is selected from the group consisting of panthenol, -bisabolol, betaine, monoammonium glycyrrhizate (MAG), lipochroman, tocopheryl acetate, phytosphingosine, extracts of green tea, extracts of Sophora flavescens root, extracts of chamomile (e.g. Anthemis nobilis), extracts of Aloe vera, extracts of Echinacea, extracts of willow bark, extracts of willow herb, extracts of almond, extracts of oats, glycyrrhizic acid, extracts of Kola, extracts of red clover, salicylic acid, xymeninic acid, turmeric, and combinations thereof; and/or (ii) is present in an amount of: (a) from about 0.0001% to about 10% by weight of the respective composition; or (b) from about 0.0001% to about 5% by weight of the respective composition; or (c) from about 0.005% to about 3% by weight of the respective composition.

9. The kit of claim 1, wherein in compositions (1), (2), (3), (4) and (5), the polyphenolic antioxidant agent: (i) is selected from the group consisting of extracts of: green tea, extracts of mulberry, ginseng, raspberry, oregano, white tea, red tea, Mohani tea, black tea, Oolong tea, yellow tea, jasmine tea, Pu Erh tea, blueberry, French maritime pine bark, rosemary, grape, including grape seed, fennel, Caragana sinica, majaoram, crocus, apple, coffee, green coffee, cherry, snow algae, Emblica, ginkgo, moringa, ginger, magnolia, French saffron, edelweiss, white lotus, turmeric root, marshmallow, burdock, bilberry, cranberry, pomegranate, sage, thyme, sunflower, wild carrot, hop, witch hazel, oak, Camellia, red clover, flax, lemon, birch, cornflower, geranium, polygonum, soy, Sophora and combinations thereof; and/or (ii) is present in an amount of: (a) from about 0.0001% to about 20% by weight of the respective composition; or (b) from about 0.0001% to about 10% by weight of the respective composition; or (c) from about 0.0001% to about 5% by weight of the respective composition.

10. The kit of claim 1, wherein in compositions (1), (2), (3) (4) and (5), the antioxidant vitamin: (i) is selected from the group consisting of vitamin C (ascorbic acid), vitamin E (tocotrienol and/or tocopherol) and beta carotene, derivatives thereof, and combinations thereof; and/or (ii) is present in an amount of: (a) from about 0.01% to about 20% by weight of the respective composition; or (b) from about 0.01% to about 10% by weight of the respective composition; or (c) from about 0.05% to about 5% by weight of the respective composition.

11. The kit of claim 1, wherein in compositions (1), (3) (4) and (5) the skin-soothing agent: (i) is selected from the group consisting of glycerin, butylene glycol, allantoin, shea butter, sodium hyaluronate, biosaccharide gum-1, jojoba oil, isononyl isononanoate, carnauba wax, Aloe Vera, chamomile, comfrey, oatmeal, coconut oil, honey, cocoa butter, almond oil and combinations thereof; and/or (ii) is present in an amount of: (a) from about 0.01% to about 50% by weight of the respective composition; or (b) from about 0.1% to about 40% by weight of the respective composition; or (c) from about 1% to about 35% by weight of the respective composition.

12. The kit of claim 1, wherein in composition (2), the sphingosine compound in the sebum control agent: (i) is selected from the group consisting of dihydrosphingosine (sphinganine), phytosphingosine, salicyloyl phytosphingosine (phytosphingosine SLC), phytosphingosine hydrochloride (phytosphingosine HCl), sphingonine, hydroxysphingosine, and sphingosine-1-phosphate, and combinations thereof; and/or (ii) is present in an amount of: (a) from about 0.001% to about 10% by weight of the skin-balancing composition; or (b) from about 0.01% to about 5% by weight of the skin-balancing composition; or (c) from about 0.01% to about 0.5% by weight of the skin-balancing composition.

13. A method of using the kit as defined in claim 1, by applying each of the cosmetic compositions is as a topical application on the skin at least once a day.

14. (canceled)

15. A method of cosmetically treating skin damage as a result of pollution insult, or of cosmetically preventing the detrimental effects of pollution to the skin, said method comprising using the kit as defined in claim 1, in which each of the cosmetic compositions is applied as a topical application on the skin at least once a day.

Description

[0275] There now follows by way of example only a description of the present invention with reference to the accompanying drawings, in which:

[0276] FIG. 1 shows a list of example cleansing compositions according to the invention;

[0277] FIG. 2 shows a list of example skin-balancing compositions according to the invention;

[0278] FIG. 3 shows a list of example daytime protective compositions according to the invention;

[0279] FIG. 4 shows a list of example overnight treatment compositions according to the invention;

[0280] FIG. 5 shows a list of example intensive moisture products according to the invention;

[0281] FIG. 6 shows a list of example anti-shine products according to the invention;

[0282] FIG. 7 shows a list of example acne treatment products according to the invention; and

[0283] FIG. 8 is a graph showing the percentage IL-6 inhibition in skin cells in the presence of anti-inflammatory agents and in the presence of skin-soothing agents.

EXAMPLES

Example 1

Interleukin-6 (IL-6) Assay

[0284] Interleukin-6 (IL-6) bioactivity in skin cells was measured. IL-6 is a cytokine and used as a biomarker for inflammation. Skin cells (keratinocytes or fibroblasts) were placed under UV stress to induce an IL-6 response in the presence of anti-inflammatory agents or skin-soothing agents to determine their activity in inhibiting an IL-6 response.

[0285] Cells (keratinocytes or fibroblasts) were taken from culture, seeded in a 96-well plate at a density of 5000 cells per well in cell growth media with supplements and left to incubate for 24 hours at 37 C. Determination of cell number for the purpose of plating was performed in accordance with standard methods known in the art.

[0286] After incubation, the cell growth media was replaced with 100 l of PBS without calcium and magnesium and containing the relevant concentration of agent(s) required. Controls include untreated irradiated and non-irradiated samples which require 100 l pure PBS without calcium and magnesium or containing a maximum of 0.1%. Dimethyl sulfoxide (DMSO) was used where necessary to dissolve the agent(s). Salicylic acid is the positive control for this assay.

[0287] The cells were incubated with the agents for 30 minutes at 37 C. before being irradiated with a UV dose of 61,500 Joules/m2.

[0288] After irradiation, the PBS and agents were replaced with 100 l of pre-warmed (37 C.) media without supplements and incubated for 24 hours at 37 C.

[0289] Media supernatant containing the 11-6 expressed from the cells was then collected and transferred to a fresh 96-well plate and stored at 20 C. until the ELISA was performed. The 11-6 ELISA was performed according to the manufacturer's protocol provided with the kit and as standard in the art.

[0290] A cell viability assay was performed on remaining cells where necessary to determine the cytotoxic effects of tested agents.

[0291] FIG. 1 shows that the percentage IL-6 inhibition in skin cells in the presence of the anti-inflammatory agents was higher (at least 40% IL-6 inhibition) than in the presence of the skin-soothing agents (which achieved no more than 30% IL-6 inhibition).

Example 2

User Observations

[0292] Users carried out the following regimen twice a day for twenty eight days: application of a cleansing composition comprising aqua, betaine (0.5%), bisabolol (0.05%) and green tea extract (0.001%) followed by rinsing of the cleansing composition, followed by application of a skin balancing composition comprising aqua, O. japonicas root extract (3%), green tea extract (0.0025%) and sphinganine (0.1%), followed by the application of a daytime protective composition comprising aqua, octocrylene (7.5%), green tea extract (0.0025%) and glycerin (3.5%).

[0293] Users observed that skin was noticeably softer after just a few days, that skin looked great after two days and that skin looked more even and brighter. It was reported that, whilst use of the skin balancing composition alone could lead to initial skin tightness, this was alleviated by the use of the cleansing composition and the daytime protective composition in combination with the skin balancing composition. One user reported that the regimen above led to a surprising reduction in skin pore size, less skin breakouts and more balanced skin (i.e. fewer periods of dry skin and fewer periods of oily skin). Another user reported less oily skin for most of the day, unclogged pores and more balanced skin. Another user reported that after using the regimen the skin looked younger, more even toned, super clear and beautiful. Another user reported that the regimen work much more effectively compared to other skin regimens present on the market. Another user reported that this was one of the best facial regimes they have ever used.

Example 3

User Trial Study

[0294] A panel of 300 women aged between 20 and 40, with a mix of skin types (normal, oily, dry or a combination) and a mix of ethnicities were recruited. The women recruited were all regular users of skin preparations that promote skin health (i.e. they used day creams on the market three to four times a week and used night creams on the market three to four times a week).

[0295] The panel were asked to use a skin balancing composition comprising aqua, O. japonicas root extract (3%), green tea extract (0.0025%) and sphinganine (0.1%) twice a day in combination with the skincare products the women usually use for four weeks. The same panel were then asked to carry on using the above skin balancing composition but to also replace their other skincare products with a cleansing composition comprising aqua, betaine (0.5%), bisabolol (0.05%) and green tea extract (0.001%), a daytime protective composition comprising aqua, octocrylene (7.5%), green tea extract (0.0025%) and glycerin (3.5%) and an overnight treatment composition comprising aqua, green tea extract (0.001%), vitamin C (0.2%) and glycerin (3%). For the last four weeks of the study, the following regimen was followed: in the morning application of the cleansing composition followed by rinsing of the cleansing composition, followed by application of the skin balancing composition, followed by the application of the daytime protective composition, then at night application of the cleansing composition followed by rinsing of the cleansing composition, followed by application of the skin balancing composition, followed by the application of the overnight treatment composition.

[0296] The vast majority of the panel reported that the cleansing composition, daytime protective composition and overnight treatment composition, when combined with the skin balancing composition, led to skin looking healthier (93%), looking more balanced (92%), feeling more balanced (92%), feeling smoother (95%), feeling more moisturized (93%), looking more even (93%), looking more radiant (91%) and looking less oily (88%).

[0297] Furthermore, one user reported that this regimen really worked together and provided clearer skin that the skin balancing composition alone did not provide. Another user carrying out this regimen reported that my skin is softer and smoother and looks less tired and dull.