HYPOCHLOROUS ACID BASED EYE DROP AND OPHTHALMIC COMPOSITION

Abstract

The embodiments herein disclose a hypochlorous acid based ophthalmic composition, comprising stabilized hypochlorous acid. The stabilized hypochlorous acid is added in the ophthalmic composition as an anti-microbial agent and/or a preservative. The stabilized hypochlorous acid is added in the ophthalmic composition to be utilized for contact lens solution. The stabilized hypochlorous acid is added in the ophthalmic composition in a non-toxic predetermined amount. The non toxic predetermined amount of stabilized hypochlorous acid less than 0.05% v/v. The stabilized hypochlorous acid is added in the ophthalmic composition as a preservative in a predetermined amount ranging 0.0005% v/v-0.05% v/v. The stabilized hypochlorous acid is added in the ophthalmic composition as an anti-microbial agent after determining free available chlorine. The free available chlorine in the stabilized hypochlorous acid is in a range of 50 ppm-500 ppm. The predetermined ophthalmic compositions are selected from a group consisting of eyedrop solution, eyedrop suspension, eyedrop gel and ointment. anti-microbial eye drops, eye cleansing drops, ophthalmic lubricants and contact lens solutions.

Claims

1. A hypochlorous acid based ophthalmic composition, the composition comprises: stabilized hypochlorous acid, and wherein the stabilized hypochlorous acid is stabilized by a predetermined protocol, and wherein the stabilized hypochlorous acid is added in the ophthalmic composition as an anti-microbial agent in a predetermined amount, and wherein the stabilized hypochlorous acid is added in the ophthalmic composition as a preservative in a predetermined amount, and wherein the stabilized hypochlorous acid is added in the ophthalmic composition to be utilized for contact lens solution and wherein the stabilized hypochlorous acid is added in the ophthalmic composition as a non-toxic component in a predetermined amount.

2. The composition according to claim 1, wherein the predetermined amount of stabilized hypochlorous acid added as the non-toxic component less than 0.05% v/v.

3. The composition according to claim 1, wherein the stabilized hypochlorous acid is added in the ophthalmic composition as a preservative in a predetermined amount ranging 0.0005% v/v-0.05% v/v.

4. The composition according to claim 1, wherein the stabilized hypochlorous acid is added in the ophthalmic composition as an anti-microbial agent after determining free available chlorine (FAC), and wherein the free available chlorine (FAC) in the stabilized hypochlorous acid is in a range of 50 ppm-500 ppm.

5. The composition according to claim 1, wherein the predetermined ophthalmic compositions are selected from a group consisting of anti-microbial eye drops, eye cleansing drops, ophthalmic lubricants and contact lens solutions.

6. The composition according to claim 1, wherein the predetermined ophthalmic compositions are selected from a group consisting of eyedrop solution, eyedrop suspension, eyedrop gel and ointment.

7. The composition according to claim 1, wherein the predetermined ophthalmic compositions consisting of solution, suspension, gel, or ointment are selected to be utilized as an antimicrobial or preservative.

Description

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0033] In the following detailed description, a reference is made to the accompanying drawings that form a part hereof, and in which the specific embodiments that may be practiced is shown by way of illustration. The embodiments are described in sufficient detail to enable those skilled in the art to practice the embodiments and it is to be understood that the logical, mechanical and other changes may be made without departing from the scope of the embodiments. The following detailed description is therefore not to be taken in a limiting sense.

[0034] The embodiments herein provide an ophthalmic composition comprising stabilized hypochlorous acid as preservative. The embodiments herein further provide an ophthalmic composition comprising stabilized hypochlorous acid as anti-microbial agent. The embodiments herein also provide an ophthalmic composition comprising stabilized hypochlorous acid which is not toxic to the human eyes.

[0035] According to one embodiment herein, a hypochlorous acid based ophthalmic composition comprises stabilized hypochlorous acid. The stabilized hypochlorous acid is stabilized by a predetermined protocol. The stabilized hypochlorous acid is added in the ophthalmic composition as a preservative in a predetermined amount. The stabilized hypochlorous acid is added in the ophthalmic composition as an anti-microbial agent in a predetermined amount. The stabilized hypochlorous acid is added in the ophthalmic composition in a non-toxic predetermined amount.

[0036] According to one embodiment herein, the non toxic predetermined amount of stabilized hypochlorous acid is in a range of 0.0002% v/v-0.03% v/v.

[0037] According to one embodiment herein, the stabilized hypochlorous acid is added in the ophthalmic composition as a preservative in a predetermined amount ranging 0.0005% v/v-0.02% v/v.

[0038] According to one embodiment herein, the stabilized hypochlorous acid is added in the ophthalmic composition as an anti-microbial agent after determining free available chlorine (FAC). The free available chlorine (FAC) in the stabilized hypochlorous acid is in a range of 100 ppm-500 ppm.

[0039] According to one embodiment herein, the predetermined ophthalmic compositions are selected from a group consisting of anti-microbial eye drops, eye cleansing drops, ophthalmic lubricants and contact lens solutions.

[0040] According to one embodiment herein, the stabilized hypochlorous acid is used with a concentration being in the range of 0.002% v/v-0.03% v/v. The ophthalmic composition comprising stabilized hypochlorous acid, where the hypochlorous acid acts both as preservative and anti-microbial agent.

[0041] According to one embodiment herein, use of stabilized hypochlorous acid in a range of 0.0005% v/v-0.02% v/v as a preservative for eye drop composition. The use of stabilized hypochlorous acid illustrates no toxicity. Hence the use of stabilized hypochlorous acid as preservative and as an ophthalmic anti-microbial composition illustrates no side effects.

[0042] According to one embodiment herein, the composition for the eye drops comprises hypochlorous acid comprising free available chlorine (FAC) in a range of 100 ppm to 500 ppm. Depending on the therapeutic requirement, a specific free available chlorine is determined.

[0043] According to one embodiment herein, the ophthalmic composition comprising hypochlorous acid as preservative comprises hypochlorous acid in a range of 0.0005% v/v to 0.02% v/v. The specific range is predetermined based on the eye drop formulation and requirement.

[0044] According to one embodiment herein, the hypochlorous acid can also be utilized as contact lens solution in predetermined concentration.

[0045] According to one embodiment herein, the hypochlorous acid is manufactured and stabilized by a predetermined protocol. The hypochlorous acid is stored in a suitable container for topical ophthalmic application. Before packing the hypochlorous acid in the container, the container is flushed with an inert gas to remove any other air/gas and replace the gap with inert gas prior sealing.

[0046] It is to be understood that the phraseology or terminology employed herein is for description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the appended claims.

[0047] Although the embodiments herein are described with various specific embodiments, it will be obvious for a person skilled in the art to practice the invention with modifications. However, all such modifications are deemed to be within the scope of the claims.

[0048] It is also to be understood that the following claims are intended to cover all of the generic and specific features of the embodiments described herein and all the statements of the scope of the embodiments which as a matter of language might be said to fall there between.