Intraocular lens having an extended depth of focus

Abstract

An intraocular lens, comprising an optic having an anterior surface and a posterior surface, providing a refractive base power, at least one of the anterior surface and the posterior surface having disposed thereon a profile comprising steps having heights determined by combining three constituent diffractive profiles. The diffractive profiles correspond to powers p1, p2 and p3, the powers being different than one another and each power being a positive power less than about 1D or about 1.25D. Each of the diffractive profiles having step heights causing a phase delay, relative to aqueous fluid, of 0.6 to 1.2 times 2 for 546 nm light. The combined profile defined by the function: z=max (diffractive profile (p1), diffractive profile (p2), diffractive profile (p3)), where p3>p2>p1.

Claims

1. A monofocal intraocular lens, comprising: an optic having an anterior surface and a posterior surface, providing a refractive base power, at least one of the anterior surface and the posterior surface having disposed thereon a combined profile comprising steps having heights determined by combining three constituent diffractive profiles, the diffractive profiles corresponding to powers p1, p2 and p3, the powers being different than one another and each power being a positive power less than about 1D, and each of the diffractive profiles having step heights causing a phase delay, relative to aqueous fluid, of 0.6 to 1.2 times 2 for 546 nm light, the combined profile defined by the function:
z=max(diffractive profile(p1),diffractive profile(p2),diffractive profile(p3)), where p3>p2>p1.

2. The lens of claim 1, wherein the combined profile is disposed completely on the anterior surface of the lens.

3. The lens of claim 1, wherein the combined profile is disposed piecewise on both the anterior surface and posterior surface of the lens.

4. The lens of claim 1, wherein the combined profile is rotationally symmetric.

5. The lens of claim 1, wherein zones of the lens formed by the three constituent profiles are kinoform in shape.

6. The lens of claim 1, wherein each of the diffractive profiles has step heights causing a phase delay, relative to aqueous fluid, of 0.8 to 1.0 times 2 for 546 nm light.

7. The lens of claim 1, wherein the central zone has a refractive surface having a shape independent of the constituent diffractive profiles.

8. The lens of claim 1, wherein the ratio of p.sub.1 to p.sub.2 is about 0.6, and the ratio p.sub.1 to p.sub.3 is about 0.4.

9. The lens of claim 1, wherein the ratio of p.sub.1 to p.sub.2 is about 0.67, and the ratio p.sub.1 to p.sub.3 is about 0.31.

10. The lens of claim 1, wherein the depth of focus is greater than 0.85 diopters.

11. The lens of claim 8, wherein the depth of focus is greater than 0.85 diopters.

12. A monofocal intraocular lens, comprising: an optic having an anterior surface and a posterior surface, providing a refractive base power, at least one of the anterior surface and the posterior surface having disposed thereon a combined profile comprising steps having heights determined by combining three constituent diffractive profiles, the diffractive profiles corresponding to powers p1, p2 and p3, the powers being different than one another and each power being a positive power less than about 1.25D, and each of the diffractive profiles having step heights causing a phase delay, relative to aqueous fluid, of 0.6 to 1.2 times 2 for 546 nm light, the combined profile defined by the function:
z=max(diffractive profile(p1),diffractive profile(p2),diffractive profile(p3)), where p3>p2>p1.

13. The lens of claim 12, wherein the combined profile is disposed completely on the anterior surface of the lens.

14. The lens of claim 12, wherein the combined profile is disposed piecewise on both the anterior surface and posterior surface of the lens.

15. The lens of claim 12, wherein the combined profile is rotationally symmetric.

16. The lens of claim 12, wherein zones of the lens formed by the three constituent profiles are kinoform in shape.

17. The lens of claim 12, wherein each of the diffractive profiles has step heights causing a phase delay, relative to aqueous fluid, of 0.8 to 1.0 times 2 for 546 nm light.

18. The lens of claim 12, wherein the central zone has a refractive surface having a shape independent of the constituent diffractive profiles.

19. The lens of claim 12, wherein the ratio of p.sub.1 to p.sub.2 is about 0.6, and the ratio p.sub.1 to p.sub.3 is about 0.4.

20. The lens of claim 12, wherein the ratio of p.sub.1 to p.sub.2 is about 0.67, and the ratio p.sub.1 to p.sub.3 is about 0.31.

21. The lens of claim 12, wherein the depth of focus is greater than 0.85 diopters.

22. The lens of claim 19, wherein the depth of focus is greater than 0.85 diopters.

23. A set of monofocal intraocular lenses, comprising at least three lens, each of the lenses comprising an optic having an anterior surface and a posterior surface, providing a refractive base power, at least one of the anterior surface and the posterior surface having disposed thereon a combined profile comprising steps having heights determined by combining three constituent diffractive profiles, the diffractive profiles corresponding to powers p1, p2 and p3, the powers being different than one another and each power being a positive power less than about 1.25D, and each of the diffractive profiles having step heights causing a phase delay, relative to aqueous fluid, of 0.6 to 1.2 times 2 for 546 nm light, the combined profile defined by the function:
z=max(diffractive profile(p1),diffractive profile(p2),diffractive profile(p3)), where p3>p2>p1, each of the lenses of the set having a different refractive, base dioptric power than one another, the range of the refractive base powers being at least 10 diopters, and the combined profile of each of the at least three lenses being same as one another.

24. The set of intraocular lenses of claim 23, wherein the combined profile on each of the at least three lenses is the same as the combined profile of each of the other of the at least three lenses.

25. A monofocal intraocular lens, comprising: an optic having an anterior surface and a posterior surface to provide a refractive base power, at least one of the anterior surface and the posterior surface having disposed thereon a profile comprising diffractive steps, wherein, when the lens is placed in a physical model eye, a through-focus modulation transfer function (MTF) of the eye model, for a spatial frequency of 50 lp/mm, has a peak characterized by a slope of zero, and the MTF has a range extending in a myopic direction from the peak over which the MTF has a value greater than 0.2 MTF unit, the range being greater than 1.25D, the peak being the only peak in the MTF before a first zero in the MTF.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) The nature and mode of operation of the present invention will now be more fully described in the following detailed description of the invention taken with the accompanying drawing figures, in which:

(2) FIG. 1 is a schematic cross-sectional view of an example of an optical element of an intraocular lens including a combined diffractive profile according to aspects of the present invention, where the diffractive profile is magnified to facilitate discussion;

(3) FIG. 2 is a cross-sectional view of the axially-symmetric, diffractive profile of the optical element of FIG. 1 as a function of radial distance, the diffractive profile being separated from the refractive surface;

(4) FIG. 3 is a cross-section illustration of the constituent diffractive profiles that are to be combined to produce the combined diffractive profile of FIG. 2;

(5) FIG. 4 illustrates through-focus MTF plots (for 50 lp/mm at the retina) for the IOL in FIG. 1 and a refractive monofocal IOL without the combined diffractive profile respectively, and illustrates the monofocal nature as well as extended energy spread of lenses according to aspects of the present invention;

(6) FIG. 5 illustrates through-focus MTF plots (for 50 lp/mm at the retina) of examples of lenses according to aspects of the present invention where each lens is selected to have a given phase delay or multiple different phase delays, such as one for each constituent profile; and

(7) FIG. 6 is a schematic illustration of a human eye after a natural lens has been removed and an intraocular lens according to aspects of the present invention has been surgically implanted in the capsular bag of the eye.

DETAILED DESCRIPTION

(8) The inventor has discovered an unexpected result of combining multiple low-power diffractive profiles corresponding to different add powers using a max function, to form a diffractive profile for use with an intraocular lens. Embodiments of such lenses provide the lens with a depth of focus having a single peak and significant spreading of optical energy along the optical axis of the lens to provide a visually-useful, extended depth of focus with no or a reduced likelihood of photic phenomenon.

(9) FIG. 1 is a schematic cross-sectional view of an example of an optical element 100 of intraocular lens (shown in FIG. 6) including a combined diffractive profile 150 according to aspects of the present invention. Optical element 100 has an anterior surface 102 and a posterior surface 104, providing a refractive power (commonly referred to as a base power of the lens). The refractive surfaces 102, 104 of the intraocular lens can be either spherical or aspheric, and may be bi-convex, as shown in FIG. 1, or may be plano-convex, meniscus or any other suitable shape. The value zero along the horizontal axis corresponds to the optical axis OA of the lens. Combined diffractive profile 150 may be applied to a base refractive lens having any suitable positive or negative dioptric value or a dioptric value of zero.

(10) In the illustrated embodiment, anterior surface 102 has a profile comprising steps having heights h.sub.1, h.sub.2 . . . h.sub.n resulting from combining three diffractive profiles superimposed thereon. Further details of forming a combined diffractive profile are given below.

(11) Each of the three diffractive profiles corresponds to a respective power p1, p2 and p3. The powers have different magnitudes than one another. In some embodiments, each power has a positive power that is less than about 1D. In some of the embodiments, each power has a positive power that is less than about 1.25D. Each of the diffractive profiles has step heights causing a phase delay, relative to aqueous fluid, of 0.6 to 1.2 times 2 for 546 nm light. The combined profile is defined by the function:
z=max(diffractive profile(p1),diffractive profile(p2),diffractive profile(p3)) where p3>p2>p1.

(12) Although in the illustrated embodiment the combined diffractive profile is disposed on the anterior surface of the lens, the combined diffractive profile can be positioned completely on either the posterior surface or the anterior surface (as shown in FIG. 1). Alternatively, the combined profile can be positioned piece-wise on both refractive sides of the optical element. For example, a combined profile can be divided into multiple segments using lines that are parallel to the optical axis. Each segment of the profile can be located on the anterior surface of the lens or the posterior surface, while maintaining its corresponding radial location between given parallel lines.

(13) It will be appreciated that the diffractive step heights in FIG. 1 are greatly magnified relative to the remainder of optical element 100 for ease of viewing. Additionally, the sharpness of the steps is exaggerated for the purpose of illustration. It will be appreciated that some rounding of the corners of the steps may occur due to manufacturing process. This smoothening could be due to, for example, lens or lens-mold machining or subsequent lens polishing processes. Such smoothening is not expected to degrade lens performance unless excessive so as to unacceptably diminish the lenses depth of focus or monofocality.

(14) Further details of an IOL including an optical element as described herein and positioning of such an IOL in an eye are given with reference to FIG. 6 below.

(15) FIG. 2 illustrates the combined, diffractive profile 150 of the optical element of FIG. 1 in greater detail. The profile is illustrated as a profile height as a function of radial location, the diffractive profile being separated from the refractive surface 102 (i.e., zero on the vertical axis corresponds to the anterior surface of the base refractive lens). It will be appreciated that the diffractive profile of FIG. 2 is rotationally symmetric about the optical axis OA. Although the profile has eight zones, any suitable number of zones may be used.

(16) FIG. 3 illustrates the individual, constituent diffractive profiles corresponding to powers p.sub.1, p.sub.2 and p.sub.3, respectively that are combined to produce the combined diffractive profile of FIG. 2. The combined diffractive profile of FIG. 2 is produced by combining three, individual kinoform-type profiles. The three individual diffractive profiles corresponding to p.sub.1, p.sub.z, p.sub.3 are defined in equations 1(a), 1(b) and 1(c), respectively.

(17) $\begin{array}{cc}{h}_1\left(r\right)=\frac{}{\left(n_l-n_m\right)}\left\{\left(\frac{r^2}{2F_1}\right)-m_1\right\}& \mathrm{Equation}1\left(a\right)\\ h_2\left(r\right)=\frac{}{\left(n_l-n_m\right)}\left\{\left(\frac{r^2}{2F_2}\right)-m_2\right\}& \mathrm{Equation}1\left(b\right)\\ h_3\left(r\right)=\frac{}{\left(n_l-n_m\right)}\left\{\left(\frac{r^2}{2F_3}\right)-m_3\right\}& \mathrm{Equation}1\left(c\right)\end{array}$ where: r is the distance from the optical axis, is the design wavelength of light in vacuum. In the examples provided herein, the wavelength is chosen to be 546 nm where the photoreceptors in the human eye are most sensitive, n.sub.1 and n.sub.m are refractive indices of the lens material and the surrounding medium, respectively, at the design wavelength of 546 nm. In the examples provided herein, the lens refractive index value and the aqueous humor refractive index value are 1.5404 for n.sub.1 and 1.336 for n.sub.m, respectively. In the example of FIG. 3, the lens material is a hydrophobic acrylic. Other materials may be used to achieve designs according to aspects of the present invention, such as hydrophilic acrylic, polymethyl-methacrylate (PMMA) or silicone where the zone heights are chosen to achieve suitable phase delays. is a constant signifying the fraction of a 2 phase delay to be caused by light passing through the lens material relative to the same light traveling through the same thickness in the surrounding medium (e.g., aqueous fluid). A value of 0.8 for has been used to derive the diffractive profiles in FIG. 3. While in some embodiments (such as those in the example of FIG. 3) is the same for all profiles constituting the combined profile, the value of for a constituent profile of a combined profile may be different than one or all of the other constituent profiles of the combined profile. F.sub.1, F.sub.2 and F.sub.3 are the focal lengths corresponding to the powers p.sub.1, p.sub.2, and p.sub.3 chosen for creating profiles h.sub.1(r); h.sub.2(r), and h.sub.3(r) respectively. F.sub.1, F.sub.2 and F.sub.3 are given by the reciprocals of powers p.sub.1, p.sub.2 and p.sub.3 respectively. For the profiles in FIG. 3, the values of p.sub.1, p.sub.2 and p.sub.3 are 0.35D, 0.55D and 0.9D. m.sub.1, m.sub.2 and m.sub.3 each take integer values 0, 1, 2 . . . signify the diffractive zone number. 0 indicates the central zone.

(18) Although the embodiments described herein use kinoform profiles, it will be appreciated that other profiles may be used. For example, a linear profile such as a linear approximation to the kinoform shape, or other suitable approximations or shapes may be used. Also, although the example includes three constituent profiles in the combined profile, three or more constituent profiles may be used to form the combined profile. In embodiments having four or more constituent profiles, the fourth and any additional constituent profiles would have different powers than all other profiles, would have a power less than about 1 diopter (or less than about 1.25 diopters), and would be combined with the other profiles using the max function as described above.

(19) Zone boundaries of the zones of the profile shown in FIG. 3 are given by equation 2:
r.sub.m.sup.2+F.sup.2={(m+1)+F}.sup.2Equation 2 where: m indicates the zone number, F is the focal length (as indicated above), r.sub.m is the radial zone boundary for the zone number m, and is the wavelength of light in a vacuum.

(20) The constituent diffractive profiles are combined using a maximum function as shown in equation 3 to form the combined diffractive profile shown in FIG. 2.
z(r)=Max{h.sub.1(r),h.sub.2(r),h.sub.3(r)}Equation 3

(21) The values of z(r) that constitute a combined profile are taken as the maximum value (i.e., maximum thickness) of h.sub.1(r); h.sub.2(r), and h.sub.3(r), at each radial position r. As illustrated in FIG. 3, the thicknesses are measured as a deviation from zero in the negative direction. However, any convenient representation of thickness may be used.

(22) The depth of the constituent profiles in FIG. 3 is 2.136 microns, which converts to a phase imparted upon transmission of about 0.8 wavelengths, or about 288 degrees of phase. A parabolic profile associated with the kinoform shape extends across all zones, with a step discontinuity at the edge of each zone.

(23) The resulting combined profile in FIG. 2 is superimposed on a base refractive surface to form the optical element shown in FIG. 1. The superimposed shape is formed by adding the sagittal height of the refractive lens with the height of the combined diffractive profile at each radial position. In the example embodiment, the base refractive lens is a 20 diopter, biconvex lens having asphericity to substantially eliminate spherical aberration. The lens specification is as follows1) an anterior surface radius of 20.0 mm with an aspheric 4.sup.th order coefficient of 1.5810.sup.4, 2) a posterior IOL surface radius of 20.807 mm, and 3) an optic center thickness of 0.553 mm.

(24) The inventor has noted that ratios of p.sub.1 to p.sub.2 and p.sub.1 to p.sub.3 of about 0.6 and 0.4 respectively, yield a depth of focus where the MTF smoothly rolls off from a maximum with no additional local maximum between the peak and the first zero in the MTF curve. While in the illustrated embodiments the powers are 0.35D, 0.55D and 0.9D, other powers where p.sub.1 to p.sub.2 is about 0.6, and the ratio p.sub.1 to p.sub.3 is about 0.4, and the powers are less than 1 diopter may be chosen. Other ratios of p.sub.1 to p.sub.2 and p.sub.1 to p.sub.3 of about 0.67 and 0.31 respectively, have also been found to yield a depth of focus where the MTF smoothly rolls off from a maximum with no additional local maximum between the peak and the first zero in the MTF curve. For example, p.sub.1=0.39D, p2=0.58D and p.sub.3=1.25D may be used.

(25) It is to be appreciated that, in the illustrated embodiments, the zones are blazed which yields an asymmetric MTF curve, having a greater amount of energy being delivered the corneal/anterior side of the lens. While blazing may be advantageous in some embodiments, it is not necessary.

(26) While embodiments with profiles having step heights causing a phase delay (relative to aqueous fluid) of 0.6 to 1.2 times 2 for 546 nm light generate solutions with a single maximum and no additional local maximum before the first zero in the MTF, for some combinations of profiles calculated or experimental testing of the resulting lens may be desirable to confirm that a monofocal lens with a substantial depth of focus is generated. Lens embodiments with profiles having step heights causing a phase delay, relative to aqueous fluid, of 0.8 to 1.0 times 2 for 546 nm light provide monofocal lenses with an extended depth of focus more consistently. It is to be appreciated that lenses according to aspects of the present invention have a phase delay between adjacent values of greater than the 0.6 of a wavelength as compared to conventional lenses which have a phase delay of 0.5 or less as described above. While phase delays of greater than 0.6 are generally thought to provide greater light to a near focus, which has been avoided in conventional designs, the inventor has found that such designs enhance depth of focus, particularly when used in combination with a diffraction profile resulting from multiple diffraction profiles combined using a max function as described herein.

(27) Furthermore, it is to be appreciated that the above range of phase delays between adjacent zones includes phase delay of 1.0 which is conventionally associated with a high degree of monofocality. Again, the inventor has found that, due to the use of the max function, the three profiles combined using the max function permits distribution of light in a manner that enhances depth of focus.

(28) FIG. 4 shows through-focus MTF plots of the EDOF IOL in FIG. 2 and a refractive monofocal IOL for comparison. The refractive monofocal used for comparison has the same prescription as the base refractive lens of the EDOF lens and excludes the combined diffractive profile (see the base refractive lens prescription above).

(29) FIG. 4 illustrates the monofocal nature of lenses according to aspects of the present invention, as well as the spread of energy along the myopic side of optical axis caused by lenses according to aspects of the present invention. MTFs may be calculated in a straightforward numerical manner, either by a raytracing program such as Oslo from Sinclair Optics of Pittsford N.Y. or Zemax from Zemax, LLC of Kirkland, Wash. or by another existing simulation tool, or by self-written code, all of which provide equivalent results using different calculation techniques.

(30) FIG. 4 is a plot of the through-focus MTF at 50 line pairs per mm and using a 3 mm pupil aperture. The plot provides a measure of the spread of optical energy around the focal region on the optical axis. It is to be appreciated that to measure depth of focus, as illustrated in FIG. 4, requires the use of a model eye in which the intraocular lens is located either as a physical sample or as a computational model.

(31) The through-focus MTF curves in FIG. 4 and FIG. 5 are generated using computational models of the intraocular lenses specified above, in a model eye defined as Model Eye 1 in the ISO 11979-2 2014 standard for intraocular lenses. Since lens and model eye aberrations can result in some extension in depth of focus, for the illustration purposes, the model and the base refractive lens are selected such that the extension in depth of focus provided by the invented diffractive profile in FIG. 2 is not obscured, for example by presence of spherical aberration. Accordingly, the ISO Model Eye 1 was used in the examples described herein because it provides a minimal amount of spherical aberration in the cornea present therein, and the base refractive lens was selected to have an amount of spherical aberration of an opposite sign to cancel what little spherical aberration is present in Model Eye 1. While the base refractive lens used for illustration above includes a low amount aberration selected to cancel the spherical aberration of Model 1, such a configuration was selected solely illustration purposes. Lenses according to aspects of the present invention may have any suitable amount of spherical aberration that doesn't frustrate other aspects of the lens. It will be appreciated that such spherical aberration can enhance a depth of focus in a conventional manner when used in combination with features according to aspects of the present invention. The choice of 3 mm for the aperture diameter, used in the model eye for the simulations for FIG. 4 and FIG. 5, represents a typical pupil size in the human eye under photopic conditions.

(32) As seen in FIG. 4, the MTF of the extended depth of focus lens shows a depth of focus of 1.16 D from the MTF focal peak at zero defocus (i.e., an absolute maximum corresponding to best focus) using the 0.2 MTF units minimum level on the positive (i.e., myopic) defocus power side. For the MTF of the refractive aspheric monofocal without a diffractive EDOF structure in FIG. 4, the depth of focus at the 0.2 level on the myopic side is 0.53 D. Assuming that objects at infinite distance are at best focus (i.e., at the peak MTF), the depth of focus on the negative or hyperopic defocus power side is considered lost since it cannot be used in human vision.

(33) Another feature of the MTF of the extended depth of focus monofocal in FIG. 4 is the absence of MTF dips below the 0.2 MTF level between the focal peak at zero defocus and 1.16D defocus thus supporting useful vision between the lens focus and its depth of focus limit. It is to be noted that the MTF of the EDOF lens in FIG. 4 has an absolute maximum peak at an MTF level of 0.53 MTF units which is below the absolute maximum peak of the MTF of the refractive aspheric monofocal without the combined diffractive profile; however, at the peak, the MTF of the EDOF lens has a great enough value to provide uncompromised vision to the wearer. The monofocal nature of the MTF extended depth of focus monofocal in FIG. 4 is illustrated through its single peak (i.e., the absolute maximum corresponding to best focus) before the first zero in the MTF and is expected to minimize visual disturbances and confusion experienced by users of multifocal intraocular lenses.

(34) FIG. 5 illustrates through-focus MTF plots of examples of lenses according to aspects of the present invention where the constituent diffractive profiles of each lens are selected to have one or more corresponding phase delays (specified as a fraction of a 546 nm wavelength). In one embodiment, the phase delay =0.6 for each of the profiles p.sub.1=0.35D, p.sub.2=0.55D and p.sub.3=0.9D. In another of the embodiments, the phase delay =0.7 for each of the profiles p.sub.1=0.35D, p.sub.2=0.55D and p.sub.3=0.9D. In yet another embodiment, the phase delay =0.8 for each of the profiles p.sub.1=0.35D, p.sub.2=0.55D and, p.sub.3=0.9D. In still another embodiment, the phase delay =1.0 for the profile p.sub.1=0.35D, the phase delay =1.1 for the profile p.sub.2=0.55D and, the phase delay =1.0 for the profile p.sub.3=0.9D. In still another embodiment, the phase delay =1.1 for the profile p.sub.1=0.35D, the phase delay =1.22 for the profile p.sub.2=0.55D and, the phase delay =1.1 for the profile p.sub.3=0.9D. In another embodiment, the profiles are constructed such that a profile p.sub.1=0.39D has a phase delay =0.6, a profile p.sub.1=0.58D has a phase delay =0.88 and, a profile p.sub.1=1.25D has a phase delay =0.75 for 546 nm light.

(35) It is to be appreciated from FIG. 5 that the shape of the through-focus MTF curve is sensitive to the value(s) . It is also to be appreciated that, in the illustrated examples, there is shorter depth of focus for of 0.6 and broad MTF profile with an increased depth of focus as approaches a value of 1.2. However, each of the illustrated lens embodiments exhibits an extended depth of focus. Furthermore, three of the curves in FIG. 5 correspond to lenses where MTF curves demonstrate that constituent diffractive profiles of a given combined profile can have different values of than one another. In some embodiments, the depth of focus is greater than 0.85 diopters when in Model Eye 1. In other embodiments it is greater than 1.0 diopter. In still others it is greater than 1.25 diopters. The depth of focus may be achieved in a lens that is without spherical aberration or in a lens with spherical aberration.

(36) FIG. 5 illustrates through-focus MTF plots of examples of lenses according to aspects of the present invention where the constituent diffractive profiles of each lens are selected to have one or more corresponding phase delays (specified as a fraction of a 546 nm wavelength). In one embodiment, the phase delay =0.6 for each of the profiles p.sub.1=0.35D, p.sub.2=0.55D and p.sub.3=0.9D. In another of the embodiments, the phase delay =0.7 for each of the profiles p.sub.1=0.35D, p.sub.20.55D and p.sub.30.9D. In yet another embodiment, the phase delay =0.8 for each of the profiles p.sub.1=0.35D, p.sub.2=0.55D and, p.sub.3=0.9D. In still another embodiment, the phase delay =1.0 for the profile p.sub.1=0.35D, the phase delay =1.1 for the profile p.sub.2=0.55D and, the phase delay =1.0 for the profile p.sub.3=0.9D. In still another embodiment, the phase delay =1.1 for the profile p.sub.1=0.35D, the phase delay =1.22 for the profile p.sub.2=0.55D and, the phase delay =1.1 for the profile p.sub.3=0.9D. In another embodiment, the profiles are constructed such that a profile p.sub.1=0.39D has a phase delay =0.6, a profile p.sub.2=0.58D has a phase delay =0.88 and, a profile p.sub.3=1.25D has a phase delay =0.75 for 546 nm light.

(37) FIG. 6 shows a human eye 10, after an intraocular lens 1 according to aspects of the present invention has been surgically implanted. Light enters from the left of FIG. 6, and passes through cornea 14, anterior chamber 15, iris 16, and enters capsular bag 17. Capsular bag 17 houses intraocular lens 1 in addition to aqueous fluid which occupies the remaining volume and equalizes the pressure in the eye 10. After passing through intraocular lens 1, light exits posterior wall 18 of the capsular bag 17, passes through posterior chamber 11, and strikes retina 12. The retina detects the light and converts it to a signal transmitted through optic nerve 8 to the brain.

(38) Intraocular lens 1 has an optic 1a that has a refractive index greater than the aqueous fluid that surrounds it and, typically, the refractive power of an intraocular lens is in the range of about 5 Diopters to about 30 Diopters to compensate for the loss of natural lens which it typically replaces.

(39) Optic 1a has an anterior surface 2 facing away from the retina 12 and a posterior surface 3 facing toward the retina 12. As illustrated, an optic 1a is held in place by one or more haptics 19, which couple optic 1a to the capsular bag 19. The one or more haptics may be of any known or yet to be developed configuration (e.g., plate, wire, C-loop, J-loop), and may be of an accommodating or non-accommodating type. In some embodiments, the IOL may have no haptics.

(40) Optic 1a intraocular lens 1 may be disposed adjacent to, and even pressed against, the posterior wall 18, for example, to reduce cellular growth on optic 1a. Alternatively, optical 1a may be positioned within the capsular bag 17 in a position spaced away from the posterior wall 18, for example, to allow accommodative movement of optic 1a of the intraocular lens 1 along the optical axis (i.e., the lens is as an accommodative IOL); however, it will be appreciated that advantages of the extended depth of focus features of the lenses according to aspects of the present invention facilitate extended vision without complications that may result from accommodative movement.

(41) A well-corrected eye forms an image of a distant object (i.e., an object at optical infinity) at retina 12. If the lens has too much or too little power, the image shifts axially along the optical axis away from retina 12 a corresponding distance toward or away from lens 1. Note, the power required to focus a close or near object onto the retina is greater than the power required to focus a distant or far object onto the retina.

(42) In some instances lenses having diffractive profiles as set forth above are provided on each lens of an intraocular lens set. The lenses of the set have different base powers (i.e., refractive powers) than one another. A lens set has a range of dioptric powers of at least 10 diopters, and comprises at least three lenses. In some embodiments, the lenses of the lens set have a same combined diffractive profile on each lens (i.e., the lenses have different refractive power and the same combined diffractive profile disposed thereon to provide an enhanced depth of field). For example, the refractive powers of the lens set may range from 10D to 30D, the lenses having increments of 0.5D (i.e., 41 lenses).

(43) It will be appreciated that several of the above-disclosed features and functions, or alternatives thereof, may be desirably combined into many other different systems or applications. Also that various presently unforeseen or unanticipated alternatives, modifications, variations, or improvements therein may be subsequently made by those skilled in the art which are also intended to be encompassed by the following claims.