ANTI-INFLAMMATORY LIQUID COMPOSITION FOR COVERING ORAL MUCOSA AND PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF STOMATITIS USING SAME

Abstract

An anti-inflammatory liquid composition for covering oral mucosa includes: a rosin; a shellac; and a solvent. A content of the rosin is 1 wt % or more and 15 wt % or less relative to a total amount of the composition. A content of the shellac is 35 wt % or more and 45 wt % or less relative to the total amount of the composition. A total content of the rosin, the shellac, and a copal is 45 wt % or more and 55 wt % or less relative to the total amount of the composition.

Claims

1. An anti-inflammatory liquid composition for covering oral mucosa comprising: a rosin; a shellac; and a solvent; wherein a content of the rosin is 1 wt % or more and 15 wt % or less relative to a total amount of the composition, and a content of the shellac is 35 wt % or more and 45 wt % or less relative to the total amount of the composition, and a total content of the rosin, the shellac, and a copal is 45 wt % or more and 55 wt % or less relative to the total amount of the composition.

2. The anti-inflammatory liquid composition for covering oral mucosa according to claim 1, further comprising a copal.

3. The anti-inflammatory liquid composition for covering oral mucosa according to claim 2, wherein a content of the copal is more than 0 wt % and 10 wt % or less relative to a total amount of the composition.

4. The anti-inflammatory liquid composition for covering oral mucosa according to claim 1, wherein the solvent contains ethanol.

5. The anti-inflammatory liquid composition for covering oral mucosa according to claim 1, further comprising an accessory ingredient containing a medicinal ingredient and/or a moisturizing ingredient.

6. The anti-inflammatory liquid composition for covering oral mucosa according to claim 5, wherein a content of the accessory ingredient is 1 wt % or less relative to a total amount of the composition.

7. The anti-inflammatory liquid composition for covering oral mucosa according to claim 5, wherein the medicinal ingredient contains one or two or more selected from the group consisting of an anti-inflammatory agent, an antihistamine, an anti-inflammatory analgesic, an antibiotic, a vitamin preparation, a herbal medicine, and a Kampo preparation.

8. The anti-inflammatory liquid composition for covering oral mucosa according to claim 5, wherein the moisturizing ingredient contains one or two or more selected from the group consisting of glycerin, wheat germ oil, macadamia nut oil, olive oil, jojoba oil, castor oil, and a plant extract.

9. A pharmaceutical composition for preventing and/or treating stomatitis, comprising the anti-inflammatory liquid composition for covering oral mucosa according to claim 1.

Description

DESCRIPTION OF EMBODIMENTS

[0015] One aspect of the present invention is an anti-inflammatory liquid composition for covering oral mucosa including: a rosin; a shellac; and a solvent in which a content of the rosin is 1 wt % or more and 15 wt % or less relative to a total amount of the composition, and a content of the shellac is 35 wt % or more and 45 wt % or less relative to the total amount of the composition, and a total content of the rosin, the shellac, and a copal is 45 wt % or more and 55 wt % or less relative to the total amount of the composition.

[0016] It is known that the rosin has antibacterial and anti-inflammatory effects against cariogenic bacteria and periodontopathic bacteria, as described in the documents in the related art. However, it has not been known that the wound site or inflamed site is covered with a rosin-containing film in order to protect the inflammation, wound, or the like in the oral cavity from external irritation and at the same time to maintain antibacterial and anti-inflammatory effects. As a result of studies by the present inventors, it has been demonstrated that the anti-inflammatory effect of the rosin is exhibited when the content of the rosin is more than 0.1 wt %. Therefore, in the case of using the composition according to the present invention in the oral cavity, the lower limit value of the content of the rosin is set to 1 wt % in consideration of gradual dissolution and permeation, on the assumption that the above-mentioned effect is exhibited when the content of the rosin is 10 times that of the composition.

[0017] In addition, since the rosin is a resin ingredient obtained from pine tar, an ethanol solution of rosin has a film-forming property. However, when the film is formed with a solution of rosin alone, there is a problem that the durability of the film is short. Also, in this case, there is a problem that irritation to the mucous membrane is strong, there is a stiff feeling due to the film in the oral cavity, and there is discomfort at the time of use. Furthermore, generally, rosin is commercially available as solid gum rosin. When the rosin is used in the composition for covering oral mucosa, it is necessary that the rosin is dissolved in a solvent such as ethanol and used. Here, in order to produce an ethanol solution of rosin, the rosin is put into ethanol and dissolved under stirring. Although it is sufficient to stir the rosin solution for several minutes when the concentration of the rosin solution is several wt %, it may take several hours to stir the solution when the concentration increases. In addition, since the rosin is irritating, when the amount of rosin is increased, the affected area may be stimulated to cause pain, and therefore it is not preferable to excessively increase the concentration of the rosin. Furthermore, when the concentration of the rosin dissolved in the ethanol solvent is excessively increased, there are problems that the surface of the film formed by applying the rosin to the affected area is rough, the touch on the tongue is deteriorated, and not only discomfort is given, but also the surface of the film is cracked and easily peeled off.

[0018] On the other hand, since the shellac as a vehicle (base material) for film formation has better performance than the rosin, it is considered that the shellac is further added in addition to the rosin, resulting in more preferable blending of the base material. Usually, shellac is commercially available as a 20 to 50% ethanol solution. Therefore, the addition of ethanol to the commercially available solution enables a shellac solution having a concentration lower than the commercially available solution to be easily obtained. In order to obtain an ethanol solution having a concentration higher than 50%, preparation can be performed by evaporating the ethanol portion in a warm bath at around 40° C. or by adding dry powder shellac to the commercially available solution.

[0019] The anti-inflammatory liquid composition for covering oral mucosa according to the present invention which has been completed based on the above findings is characterized in that the composition contains resin ingredients: a rosin and a shellac, and solvents thereof as main ingredients. Ethanol is preferably used as the solvent.

[0020] In the anti-inflammatory liquid composition for covering oral mucosa according to the present invention, the content of the rosin as the resin ingredient described above is 1 wt % or more and 15 wt % or less, and preferably 1 wt % or more and 10 wt % or less relative to the total amount of the composition. Similarly, the content of the shellac as the resin ingredient is 35 wt % or more and 45 wt % or less, and preferably 35 wt % or more and 40 wt % or less relative to the total amount of the composition. It is essential that the total content of the rosin, the shellac, and a copal is 45 wt % or more and 55 wt % or less, and the total content is preferably 47 wt % or more and 51 wt % or less relative to the total amount of the composition. Here, the composition according to the present invention does not necessarily contain the copal, but when the composition does not contain the copal, the total content of the rosin and the shellac satisfies the above definition. When the anti-inflammatory liquid composition for covering oral mucosa according to the present invention having such characteristics is applied to a mucous membrane in the oral cavity, a solvent such as ethanol evaporates and a resin film is formed. The content of the solvent in the anti-inflammatory liquid composition for covering oral mucosa according to the present invention is 55 wt % or less, and preferably 53 wt % or less. On the other hand, the lower limit of the content of the solvent is preferably 40 wt % or more, more preferably 44 wt % or more, and particularly preferably 49 wt % or more. For example, when the solvent is ethanol, the content of ethanol in the composition is preferably 53 wt % or less. On the other hand, the lower limit of the content of ethanol is preferably 40 wt % or more, more preferably 44 wt % or more, and particularly preferably 49 wt % or more. The content of the solvent (e.g., ethanol) is preferably in a range of 49 to 53 wt %.

[0021] Furthermore, in the anti-inflammatory liquid composition for covering oral mucosa according to the present invention, the contents of ethyl cellulose, polyvinyl acetate, and cellulose nitrate (the total content when a plurality of these materials is contained) are preferably less than 0.5 wt %. More preferably, the contents of film-forming polymeric substances including ethyl cellulose, polyvinyl acetate, and cellulose nitrate (excluding the rosin, the shellac, and the copal) are less than 0.5 wt %. This is because when the contents of the ingredients described above are 0.5 wt % or more, the quick-drying property of the film formed in the oral cavity may be deteriorated. At the time of application of the composition according to the present invention, it is necessary to keep the mouth open until the composition dries, whereby the deterioration of the quick-drying property increases the pain of the user. The content of each of the ingredients described above is preferably 0.45 wt % or less, more preferably 0.3 wt % or less, still more preferably 0.2 wt % or less, particularly preferably 0.1 wt % or less, and most preferably 0 wt % (free). The term “film-forming polymeric substance” means a polymer capable of forming a thin film on the surface of an object in a drying step.

[0022] It is preferable that the anti-inflammatory liquid composition for covering oral mucosa according to the present invention further contains a copal as a resin ingredient. According to the composition according to the present invention, the surface of the film may be rough due to the blending of the rosin, but there is an advantage that the surface of the film formed can be made smoother by further containing the copal, and the stiffness can be reduced. The content of the copal is not particularly limited. Since the copal has a unique resin odor, when the blending amount of the copal is too large, the stiffness may be conversely increased. Thus, the content of the copal is preferably more than 0 wt % and 10 wt % or less, and more preferably 0.1 wt % or more and 8 wt % or less relative to the total amount of the composition.

[0023] The anti-inflammatory liquid composition for covering oral mucosa according to the present invention may further contain an accessory ingredient as long as the effect of the present invention is not adversely affected. Examples of the accessory ingredient include a medicinal ingredient and a moisturizing ingredient. The contents of these accessory ingredients are preferably 1 wt % or less relative to the total amount of the composition.

[0024] Examples of the medicinal ingredient that can be contained as an accessory ingredient include one or two or more selected from the group consisting of, for example, anti-inflammatory agents such as azulene sulfonate sodium and glycyrrhizic acid; antihistamines such as diphenhydramine hydrochloride and chlorpheniramine maleate; anti-inflammatory analgesics such as triamcinolone acetonide and dexamethasone acetate; antibiotics such as cefaclor, amoxicillin, erythromycin, and kanamycin; vitamin preparations such as vitamin B1 and vitamin E; and herbal medicines or Kampo preparations such as Angelica root, cinnamon bark, turmeric, and licorice.

[0025] Examples of the moisturizing ingredient that can be contained as the accessory ingredient include one or two or more selected from the group consisting of glycerin, wheat germ oil, macadamia nut oil, olive oil, jojoba oil, castor oil, and a plant extract. Furthermore, a titanium-containing ingredient such as titanium oxide or titanium dioxide coated mica may be added as an accessory ingredient.

[0026] The anti-inflammatory liquid composition for covering oral mucosa according to the present invention contains resin ingredients: a rosin and a shellac and solvents thereof as main ingredients. Thus, when the composition is applied to an inflamed area on the mucous membrane in the oral cavity using a brush or the like, a film can be formed to cover the inflamed site within about 20 seconds. Accordingly, it is possible to prevent external irritation. As a result, the pain of the affected area can be alleviated and the patient's burden can be reduced. In addition, since the rosin contained in the composition according to the present invention contains an anti-inflammatory ingredient, it is possible to prevent the expansion of the inflamed site. Furthermore, since the film of the composition according to the present invention covers and protects the affected area, healing of the inflamed site can be promoted.

[0027] It is also found that the rosin suppresses T cell mitogen (concanavalin A)-responsive proliferation of human peripheral-blood mononuclear cells (PBMCs), and inhibits production of five cytokines (proteins secreted from cells of the immune system: IL-6, IL-10, TNF-α, IFN-β, and IL-17) from PBMCs in a concentration-dependent manner.

[0028] Since the composition according to the present invention contains an ingredient used as a food additive as a main ingredient, the composition is safe to be swallowed. In addition, even in the case where the film is swallowed by mistake, the film dissolves naturally and does not adhere to the mucous membrane of esophagus or the like, so there is no possibility of complication occurrence, or the like.

[0029] It is essential that the content of the rosin as the resin ingredient described above is 1 wt % or more relative to the total amount of the composition. This is in consideration of the fact that although the antimicrobial effect of the rosin is recognized from 0.1 wt %, the rosin is gradually dissolved and permeated to exert its effect. On the other hand, the upper limit of the content of the rosin is 15 wt % or less relative to the total amount of the composition. When the content of the rosin is more than 15 wt %, the surface of the formed film becomes stiff and the touch on the tongue is deteriorated, or cracking occurs and the film is easily peeled off. This is problematic. In addition, from the viewpoint of production, in the case of preparing the composition according to the present invention by dissolving the rosin in an ethanol solution (usually, a solution having a concentration of 50%) of shellac, when the content of the rosin exceeds 15 wt %, it takes one day or more to dissolve the rosin, leading to deterioration of productivity. This is problematic.

[0030] It is essential that the total content of the rosin and the shellac (and further a copal in the case of containing the copal) as resin ingredients is 45 wt % or more and 55 wt % or less relative to the total amount of the composition. Here, when the total content is less than 45 wt %, there is a problem that the adhesion of the formed film to the mucous membrane and the durability are deteriorated and the film is easily peeled off. In addition, as a result of the relative increase in the content of the solvent, the irritation to the mucous membrane may be enhanced. On the other hand, when the total content is more than 55 wt %, there is also a problem that the surface of the film becomes hard to cause increased stiffness, and the quick-drying property is deteriorated. When the total content is 55 wt % or less, the composition according to the present invention is dried in about 10 to 20 seconds, but this degree is the practical limit. When the total content exceeds 55 wt %, the drying time becomes long, and when the total content is, for example, 60 wt %, it takes several minutes to dry the composition. At the time of application of the composition according to the present invention, it is necessary to keep the mouth open until the composition dries, whereby the deterioration of the quick-drying property increases the pain of the user.

[0031] As described above, it is essential that the content of the rosin in the composition according to the present invention is 1 wt % or more and 15 wt % or less relative to the total amount of the composition. The content of the shellac in the composition according to the present invention was set to a range of 35 wt % or more and 45 wt % or less relative to the total amount of the composition. As a result, the feeling of the surface of the film is made smooth, and it is possible to form a film having elasticity and high durability. Note that the film formed by applying the composition according to the present invention is practically tasteless, and even when a tongue or the like touches the film, the film cannot be easily taken off, and there is no need to refrain from drinking or eating after application.

[0032] As described above, when the composition according to the present invention further contains a copal, the total content of the rosin, the shellac, and the copal is 45 wt % or more and 55 wt % or less. With such a configuration, the content of ethanol or the like as a solvent is 55 wt % or less, and the irritation can be reduced. Note that the film formed by the composition containing the rosin, the shellac, and the copal is not easily peeled off even when the film comes into contact with water because the film is hardly soluble in water, and there is an advantage that the film has durability for several hours even when the film is applied to a portion with significant movement in the oral cavity. In addition, when the film is applied to gums or the like with little movement, it is possible to form a film having durability for 6 hours or more.

[0033] The composition according to the present invention not only has an effect of protecting stomatitis by coating the stomatitis to suppress inflammation, but also has an effect of suppressing proliferation of oral bacteria such as cariogenic bacteria and periodontopathic bacteria by the antibacterial activity of the rosin gradually dissolved in saliva because the film remains in the oral cavity for a long time. Alternatively, the composition is also available as a sustained oral dosage form or a new dosage form of transdermal absorption. Hence, according to another aspect of the present invention, there is also provided a pharmaceutical composition for preventing and/or treating stomatitis, including the anti-inflammatory liquid composition for covering oral mucosa according to the present invention.

EXAMPLES

[0034] The effects of the present invention are described with reference to the following Examples and Comparative Examples. However, the technical scope of the present invention is not limited to the following Examples.

[0035] [Preparation Example of Liquid Composition]

[0036] Liquid compositions of Examples and Comparative Examples were prepared by the following method. The blending amounts of raw materials in each of the Examples and each of the Comparative Examples are shown in Table 1 below. In addition, the blending amounts of components in each of the Examples and each of the Comparative Examples are shown in Table 2 below. In principle, the Examples and Comparative Examples shown in Tables 1 and 2 are arranged in ascending order of resin concentration.

Example 1

[0037] 10.0 wt % of gum rosin (LAWTER ARGENTINA S.A.), 80.0 wt % of Laccoat 50EDS (50% shellac-ethanol solution) (manufactured by THE JAPAN SHELLAC INDUSTRIES, LTD.), 3.3 wt % of Copal HJ-01 (30% copal-ethanol solution) (manufactured by Gifu Shellac Manufacturing Co., Ltd.), and 6.7 wt % of ethanol (99.5) Imazu Class 1 (absolute ethanol) (manufactured by IMAZU CHEMICAL CO. LTD.) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 2

[0038] 8.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, 6.7 wt % of Copal HJ-01, and 5.3 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 3

[0039] 6.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, 13.3 wt % of Copal HJ-01, and 0.7 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 4

[0040] 10.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, and 10.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 5

[0041] 10.0 wt % of gum rosin, 70.0 wt % of Laccoat 50EDS, 16.7 wt % of Copal HJ-01, and 3.3 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 6

[0042] 10.0 wt % of gum rosin, 76.0 wt % of Laccoat 50EDS, 3.3 wt % of Copal HJ-01, and 10.7 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 7

[0043] 1.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, 15.0 wt % of a solution obtained by concentrating Copal HJ-01 to a 40% ethanol solution, and 4.0 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 8

[0044] 3.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, 10.0 wt % of a solution obtained by concentrating Copal HJ-01 to a 40% ethanol solution, and 7.0 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Example 9

[0045] 6.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, 2.5 wt % of a solution obtained by concentrating Copal HJ-01 to a 40% ethanol solution, and 11.5 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 1

[0046] 33.3 wt % of gum rosin and 66.7 wt % of Laccoat 50EDS were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 2

[0047] 30.0 wt % of gum rosin, 60.0 wt % of Laccoat 50EDS, and 10.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 3

[0048] 10.0 wt % of gum rosin, 71.4 wt % of a solution obtained by concentrating Laccoat 50EDS to a 70% ethanol solution, and 18.6 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 4

[0049] 33.3 wt % of gum rosin and 66.7 wt % of Copal HJ-01 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 5

[0050] 25.0 wt % of gum rosin, 50.0 wt % of Laccoat 50EDS, and 25.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 6

[0051] 10.0 wt % of gum rosin, 50.0 wt % of Laccoat 50EDS, and 40.0 wt % of Copal HJ-01 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 7

[0052] 17.0 wt % of gum rosin, 80.0 wt % of Laccoat 50EDS, and 3.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 8

[0053] 8.0 wt % of gum rosin, 64.0 wt % of Laccoat 50EDS, 1.7 wt % of Copal HJ-01, and 26.3 wt % of Imazu Class 1 ethanol (99.5) were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 9

[0054] 10.0 wt % of gum rosin, 60.0 wt % of Laccoat 50EDS, and 30.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 10

[0055] 10.0 wt % of gum rosin, 50.0 wt % of Laccoat 50EDS, and 40.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 11

[0056] 5.0 wt % of gum rosin, 30.0 wt % of Laccoat 50EDS, and 65.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

Comparative Example 12

[0057] 50.0 wt % of gum rosin and 50.0 wt % of ethanol (99.5) Imazu Class 1 were well mixed and dissolved with a stirrer to obtain a composition in the form of uniform solution.

TABLE-US-00001 TABLE 1 Table 1 Formulation of raw material of anti-inflammatory liquid composition for covering oral mucosa Formulation ratios of raw materials (wt %) Laccoat Copal solution Ethanol Sample Nos. Gum rosin *1 *2 *3 Total Example 1 10.0 80.0 3.3 6.7 100.0 Example 2 8.0 80.0 6.7 5.3 100.0 Example 3 6.0 80.0 13.3 0.7 100.0 Example 4 10.0 80.0 0.0 10.0 100.0 Example 5 10.0 70.0 16.7 3.3 100.0 Example 6 10.0 76.0 3.3 10.7 100.0 Example 7 1.0 80.0 15.0 *4 4.0 100.0 Example 8 3.0 80.0 10.0 *4 7.0 100.0 Example 9 6.0 80.0  2.5 *4 11.5 100.0 Comparative 33.3 66.7 0.0 0.0 100.0 Example 1 Comparative 30.0 60.0 0.0 10.0 100.0 Example 2 Comparative 10.0 71.4 *5 0.0 18.6 100.0 Example 3 Comparative 33.3 0.0 66.7 0.0 100.0 Example 4 Comparative 25.0 50.0 0.0 25.0 100.0 Example 5 Comparative 10.0 50.0 40.0 0.0 100.0 Example 6 Comparative 17.0 80.0 0.0 3.0 100.0 Example 7 Comparative 8.0 64.0 1.7 26.3 100.0 Example 8 Comparative 10.0 60.0 0.0 30.0 100.0 Example 9 Comparative 10.0 50.0 0.0 40.0 100.0 Example 10 Comparative 5.0 30.0 0.0 65.0 100.0 Example 11 Comparative 50.0 0.0 0.0 50.0 100.0 Example 12 *1 = Laccoat 50EDS *2 = Copal HJ-01 *3 = Ethanol (99.5) Imazu Class 1 *4 = Solution obtained by concentrating Copal HJ-01 to a 40% copal-ethanol solution *5 = Solution obtained by concentrating Laccoat 50EDS to a 70% shellac-ethanol solution

TABLE-US-00002 TABLE 2 Table 2 Formulation of raw material of anti-inflammatory liquid composition for covering oral mucosa Formulation ratios of raw materials (wt %) Sample Nos. Rosin Shellac Copal Ethanol Total Example 1 10.0 40.0 1.0 49.0 100.0 Example 2 8.0 40.0 2.0 50.0 100.0 Example 3 6.0 40.0 4.0 50.0 100.0 Example 4 10.0 40.0 0.0 50.0 100.0 Example 5 10.0 35.0 5.0 50.0 100.0 Example 6 10.0 38.0 1.0 51.0 100.0 Example 7 1.0 40.0 6.0 53.0 100.0 Example 8 3.0 40.0 4.0 53.0 100.0 Example 9 6.0 40.0 1.0 53.0 100.0 Comparative 33.3 33.3 0.0 33.4 100.0 Example 1 Comparative 30.0 30.0 0.0 40.0 100.0 Example 2 Comparative 10.0 50.0 0.0 40.0 100.0 Example 3 Comparative 33.3 0.0 20.0 46.7 100.0 Example 4 Comparative 25.0 25.0 0.0 50.0 100.0 Example 5 Comparative 10.0 25.0 12.0 53.0 100.0 Example 6 Comparative 17.0 40.0 0.0 43.0 100.0 Example 7 Comparative 8.0 32.0 0.5 59.5 100.0 Example 8 Comparative 10.0 30.0 0.0 60.0 100.0 Example 9 Comparative 10.0 25.0 0.0 65.0 100.0 Example 10 Comparative 5.0 15.0 0.0 80.0 100.0 Example 11 Comparative 50.0 0.0 0.0 50.0 100.0 Example 12

[0058] [Evaluation of Performance of Liquid Composition]

[0059] With respect to the liquid composition prepared in each of the above-described Examples and Comparative Examples, a sensory test using an evaluation panel of 5 subjects was performed for the irritation to the mucous membrane in the oral cavity of the human body, the feeling of the applied film, and the quick-drying property and durability of the applied film.

[0060] (1. Comparative Test of Irritation to Mucous Membrane)

[0061] For 5 subjects, the degree of irritation at the time of applying the liquid composition after wiping off saliva at the inner edge of the lower lip, i.e., a mucous membrane in the oral cavity, was evaluated according to the following three grades: 0 to 2, and the results of 5 subjects were averaged. When the average value was less than 1.5, it was determined that there was no practical problem. The results are shown in Table 3 below:

[0062] Irritation:

[0063] Almost no irritation is felt=0

[0064] Slight irritation is felt=1

[0065] Irritation is felt=2.

[0066] (2. Comparative Test of Feeling (Stiffness) of Film Formed in Oral Cavity)

[0067] The liquid composition was applied to 5 subjects after wiping off saliva at the inner edge of the lower lip, i.e., a mucous membrane in the oral cavity, followed by drying until a film was formed. Thereafter, the feeling at the lower portion of the surface of the film or the feeling in the oral cavity, i.e., tensive feeling or stiff feeling on the surface of the film, was evaluated according to the following three grades: 0 to 2, and the results of 5 subjects were averaged. When the average value was less than 1.5, it was determined that there was no practical problem. The results are shown in Table 3 below:

[0068] Stiffness:

[0069] (No stiffness is felt=0

[0070] Slight stiffness is felt=1

[0071] (Stiffness is concerned=2.

[0072] (3. Comparative Test of Quick-Drying Property of Film)

[0073] The liquid composition was applied to 5 subjects after wiping off saliva at the inner edge of the lower lip, i.e., a mucous membrane in the oral cavity. After seconds, the degree of dryness of the film was checked with a fingertip. After 20 seconds, the degree of dryness was checked again with a fingertip and evaluated according to the following three grades: 0 to 2, and the results of 5 people were averaged. When the average value was less than 1.5, it was determined that there was no practical problem. The results are shown in Table 3 below:

[0074] Quick-drying property:

[0075] (The sticky feeling of the fingertip is lost within 10 seconds=0

[0076] (The sticky feeling of the fingertip is lost within 20 seconds=1

[0077] Even after 20 seconds, the sticky feeling of the fingertip is not lost=2.

[0078] (4. Comparative Test of Durability of Film)

[0079] The liquid composition was applied to the inner edge of the lower lip and the outside of the upper gum of each of the 5 subjects. Next, it was confirmed whether or not the covering material remained every hour. At this time, checking was carried out in 1 hour, the subjects drank water or gargled lightly. In addition, checking was carried out in 2 hours, and then the subjects had meals. Furthermore, checking was carried out in 3 hours, and then the subjects were allowed to freely drink water and have meals.

[0080] Then, the time when the whole covering material was peeled off was recorded. At this time, for example, when the film was peeled off at the time of checking 1 hour later, it was recorded as 1 hour, when the film was remained at the time of checking 2 hours later, but peeled off at the time of checking 3 hours later, it was recorded as 3 hours, when the film was peeled off at the time of checking 7 hours later, it was recorded as 7 hours, and when the film was not peeled at that time, it was uniformly recorded as 8 hours. After completion of the recording, the results of 5 subjects were averaged. Then, for the inner edge of the lower lip, it was determined that there was no practical problem if the average value was 2.0 hours or more. For the outside of the upper gum, it was determined that there was no practical problem if the average value was 5.0 hours or more. The results are shown in Table 3 below. The results that do not satisfy the unacceptable evaluation criteria shown in Table 3 are indicated by “.box-tangle-solidup.”.

TABLE-US-00003 TABLE 3 Sensory test Durability Quick- The inner The outside property edge of the of the upper Sample Nos. Irritation Feeling drying lower lip gum Example 1 0.2 0.0 0.8 4.2 7.6 Example 2 0.6 0.4 0.6 3.0 8.0 Example 3 1.0 0.2 1.0 2.6 7.2 Example 4 0.2 0.6 0.8 4.0 7.4 Example 5 0.6 0.6 1.4 2.2 7.0 Example 6 0.6 0.4 0.6 3.4 8.0 Example 7 0.6 0.2 1.2 3.0 5.4 Example 8 0.8 0.0 1.2 3.4 5.8 Example 9 0.6 0.4 0.8 3.0 5.6 Comparative 0.8 0.4 2.0 .box-tangle-solidup. 2.2 7.0 Example 1 Comparative 0.2 1.0 1.6 .box-tangle-solidup. 2.6 7.0 Example 2 Comparative 0.0 0.0 2.0 .box-tangle-solidup. 3.2 8.0 Example 3 Comparative 0.8 1.6 .box-tangle-solidup. 1.6 .box-tangle-solidup. 1.4 .box-tangle-solidup. 4.2 .box-tangle-solidup. Example 4 Comparative 1.0 1.2 1.8 .box-tangle-solidup. 3.0 8.0 Example 5 Comparative 0.6 0.6 1.6 .box-tangle-solidup. 4.0 7.4 Example 6 Comparative 0.6 0.8 1.6 .box-tangle-solidup. 2.2 8.0 Example 7 Comparative 0.8 0.2 1.6 .box-tangle-solidup. 3.2 8.8 Example 8 Comparative 1.4 0.4 0.8 2.6 3.6 .box-tangle-solidup. Example 9 Comparative 1.6 .box-tangle-solidup. 0.6 1.0 4.0 6.2 Example 10 Comparative 1.8 .box-tangle-solidup. 0.0 0.2 1.8 .box-tangle-solidup. 3.4 .box-tangle-solidup. Example 11 Comparative 0.8 1.6 .box-tangle-solidup. 1.4 1.8 .box-tangle-solidup. 4.8 .box-tangle-solidup. Example 12 Unacceptable 1.5 ↑ 1.5 ↑ 1.5 ↑ 2.0 ↓ 5.0 ↓ evaluation criteria

[0081] From the results shown in Table 3, it is found that the irritation tends to deteriorate as the concentration of the solvent increases. For example, this tendency was remarkably shown in Comparative Examples 8 to 11. On the other hand, when the concentration of the solvent was too low and the concentration of the resin was too high, the quick-drying property tended to deteriorate (for example, Comparative Examples 1 to 3).

[0082] The feeling of the film surface tended to deteriorate as the rosin concentration increased. This tendency was observed in Comparative Examples 4, 5, and 12, and the like.

[0083] The addition of the copal improved the feeling of the film surface. This is apparent from the comparison between Example 4 and Comparative Example 11, for example.

[0084] The addition of the shellac improved the feeling, quick-drying property, and durability of the film. This is apparent from the fact that Comparative Examples 4 and 12 without addition of the shellac were inferior in all respects of feeling, quick-drying property, and durability.

[0085] This application is based on Japanese Patent Application No. 2019-229561 filed on Dec. 19, 2019, the disclosure of which is incorporated by reference in its entirety.