Bioengineered vocal fold mucosa for functional voice restoration
11896480 ยท 2024-02-13
Assignee
Inventors
Cpc classification
C12N5/0688
CHEMISTRY; METALLURGY
A61F2/20
HUMAN NECESSITIES
C12N2533/90
CHEMISTRY; METALLURGY
A61L27/3895
HUMAN NECESSITIES
A61L27/3813
HUMAN NECESSITIES
A61L27/3804
HUMAN NECESSITIES
C12N2509/00
CHEMISTRY; METALLURGY
C12N5/0697
CHEMISTRY; METALLURGY
International classification
A61F2/20
HUMAN NECESSITIES
Abstract
An engineered vocal fold mucosa, including an engineered lamina propria layer and an engineered squamous epithelium layer, is disclosed. The engineered lamina propria is made by seeding and culturing human vocal fold fibroblasts within a polymerized collagen scaffold, and the engineered squamous epithelium is made by culturing human vocal fold epithelial cells on the scaffold surface. The resulting engineered vocal fold mucosa is not immunogenic, and is capable of exhibiting the vibratory function and acoustic output of a native vocal fold mucosa. Accordingly, the engineered vocal fold mucosa may be implanted into the larynx to treat voice impairment.
Claims
1. A method of making an engineered vocal fold mucosa, comprising: (a) culturing a plurality of human vocal fold fibroblasts (VFFs) within a scaffold comprising polymerized collagen to form an engineered non-vascularized lamina propria; and (b) culturing a plurality of human vocal fold epithelial cells (VFEs) on a surface of the scaffold to form an engineered stratified squamous epithelium that is in contact with the engineered non-vascularized lamina propria; thereby forming an engineered vocal fold mucosa, wherein the plurality of human VFFs and the plurality of human VFEs are primary cells from a single human donor.
2. The method of claim 1, wherein the polymerized collagen is polymerized collagen, type I.
3. The method of claim 1, wherein the step of culturing the plurality of human VFEs on the scaffold surface is first performed within an epithelial cell-oriented medium in which the human VFEs are immersed.
4. The method of claim 3, further comprising culturing the plurality of human VFEs on the scaffold surface at an air-liquid interface on the scaffold surface, wherein the scaffold comprises a composition comprising both a fibroblast-oriented medium and an epithelial cell-oriented medium, and whereby the human VFEs stratify to form a squamous epithelium layer.
5. The method of claim 4, wherein the human VFEs are cultured for 1 to 3 days within the epithelial cell-oriented medium in which the human VFEs are immersed prior to the culturing at the air-liquid interface.
6. The method of claim 4, wherein the human VFEs are cultured for 5 to 50 days at the air-liquid interface on the scaffold surface.
7. The method of claim 1, wherein the step of culturing the plurality of human VFFs within the scaffold is performed when the scaffold comprises a fibroblast-oriented medium, and the step (b) of culturing is performed when the scaffold comprises a composition comprising both a fibroblast-oriented medium and an epithelial cell-oriented medium.
8. The method of claim 1, wherein prior to the culturing the human VFFs within the scaffold, the human VFFs are seeded into the scaffold at a density of between 510.sup.4 and 110.sup.6 VFF/mL.
9. The method of claim 1, wherein the human VFFs for use in the step (a) are obtained by: (a) seeding human vocal fold mucosa (HVFM) cells onto an extracellular matrix (ECM)-coated surface, whereby some of the HVFM cells adhere to the ECM-coated surface and some of the HVFM cells remain free-floating and non-adherent to generate HVFM adherent cells and HVFM non-adherent cells; and (b) culturing the HVFM adherent cells in a fibroblast-oriented medium, resulting in a subpopulation of human VFFs.
10. The method of claim 9, wherein human VFEs for use in the step (b) are obtained by the further steps of: (c) separately culturing the HVFM non-adherent cells in an epithelial cell-oriented medium, whereby the non-adherent cells become adherent cells; and (d) incubating the adherent cells in a composition comprising 0.05% trypsin to detach one or more of the adherent cells; and removing one or more of the detached cells to select the remaining adherent cells which are epithelial cells.
11. The method of claim 10, further comprising a passaging the epithelial cells, wherein the passaging comprises detaching the epithelial cells and further culturing the epithelial cells in a separate epithelial cell-oriented medium to constitute a first passage of the epithelial cells.
12. The method of claim 11, further comprising incubating the first passaged epithelial cells in a composition comprising 0.05% trypsin to detach one or more of the epithelial cells, and removing one or more of the detached epithelial cells to select the remaining adherent epithelial cells which are a subpopulation of human VFEs.
13. The method of claim 11, further comprising passaging the epithelial cells at least a second time to constitute at least a second passage.
14. The method of claim 13, wherein the human VFFs, the human VFEs, or both are obtained from the second passage, a third passage, a fourth passage, a fifth passage, a sixth passage, or any combination thereof.
15. The method of claim 9, wherein the HVFM cells are obtained from the human vocal fold mucosa by: (a) mincing the human vocal fold mucosa; and (b) enzymatically digesting the minced mucosa to release the HVFM cells from the extracellular matrix (ECM).
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
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DETAILED DESCRIPTION
(13) This application discloses engineered vocal fold mucosae made from isolated and purified human vocal fold fibroblasts and isolated and purified human VF epithelial cells, co-cultured under organotypic conditions. When grafted into larynges ex vivo, the engineered vocal fold mucosae generate physiologically appropriate vibratory behavior and acoustic output that are indistinguishable from those of native VF tissue, thus demonstrating that they have the biomechanical properties that are essential for use as an implant in treating voice impairment due to vocal fold mucosal tissue damage, loss, or disease. In addition, when grafted into humanized mice in vivo (a transgenic mouse model supporting a functional human adaptive immune system; see Schulz, L. D., et al., Nat. Rev Immunol 12, 786-798 (2012)), the mucosae survive and are well tolerated by the human adaptive immune system, indicating that implanting the engineered mucosa into the larynx of a patient would likely not trigger rejection or immune system attack against the implant.
(14) The inventors have found that using human vocal fold mucosal cells in the engineered vocal fold mucosa imparts the unique biomechanical and immunological properties that make the engineered mucosa useful as an implant for restoring vocal function in humans. Without being bound by any theory, human-sourced vocal fold mucosal cells are derived from cells that have been exposed to unique mechanical forces and vibration during voice production, and are thus specifically adapted to have the functional and underlying structural characteristics necessary to support phonation.
(15) Regarding the human immunotolerance engendered by the grafted engineered vocal fold mucosa, the vocal fold mucosal cells may have immunoprivilege conferred by the unique position in the body of the cells from which they are derived. Specifically, humans are constantly inhaling a variety of potentially immunogenic foreign matter, much of which would come in contact with the vocal fold mucosae. If the vocal fold mucosal cells were immunologically active, the vocal fold mucosa would be continuously inflamed, resulting in chronic laryngitis and other airway problems. Thus, vocal fold mucosal cells may have evolved to favor and promote immunotolerance, as exhibited by the engineered vocal fold mucosa.
(16) The engineered vocal fold mucosa is capable of exhibiting the vibratory function and acoustic output of a native vocal fold mucosa. Such capability can be measured using any of a number of specific tests known in the art, including, without limitation, the physiological, vibratory, and acoustic tests using ex vivo canine larynges that are described in detail in the Example below.
(17) In the disclosed method of making the engineered vocal fold mucosa, the human VFFs may be cultured in a fibroblast-oriented medium or in a composition containing a fibroblast-oriented medium. The human VFEs may be cultured in a epithelial cell-oriented medium or in a composition containing an epithelial cell-oriented medium. By fibroblast-oriented medium, we mean any medium known to or reasonably expected to support the maintenance, growth, and/or proliferation of human fibroblasts in culture, including, without limitation, the fibroblast-oriented medium disclosed in the Example below. By epithelial cell-oriented medium, we mean any medium known to or reasonably expected to support the maintenance, growth, and/or proliferation of human airway epithelial cells in culture, including, without limitation, the epithelial cell-oriented medium disclosed in the Example below.
(18) The human vocal fold mucosa can be useful for various in vitro and in vivo applications. Preparations for use in clinical applications must be obtained in accordance with regulations imposed by governmental agencies such as the U.S. Food and Drug Administration. Accordingly, in exemplary embodiments, the methods provided herein are conducted in accordance with Good Manufacturing Practices (GMPs), Good Tissue Practices (GTPs), and Good Laboratory Practices (GLPs). Reagents comprising animal derived components are not used, and all reagents are purchased from sources that are GMP-compliant. In the context of clinical manufacturing of a bioengineered implant for use in restoring vocal function in humans, GTPs govern cell donor consent, traceability, and infectious disease screening, whereas GMPs are relevant to the facility, processes, testing, and practices to produce consistently safe and effective products for human use. See Lu et al. Stem Cells 27: 2126-2135 (2009). Where appropriate, oversight of patient protocols by agencies and institutional panels is envisioned to ensure that informed consent is obtained; safety, bioactivity, appropriate dosage, and efficacy of products are studied in phases; results are statistically significant; and ethical guidelines are followed.
(19) As used herein, the term engineered tissue (or similar term) refers to a tissue prepared in accordance with the methods of the invention. An acceptably engineered tissue displays physical characteristics typical of the type of the tissue in vivo and functional characteristics typical of the type of the tissue in vivo, i.e., has a functional activity. For example, physical characteristics of an engineered vocal fold mucosa can include the presence of a lamina propria layer and a squamous epithelium layer. Functional characteristics of an engineered vocal fold mucosa can include the capacity of the engineered tissue for exhibiting the vibratory function and acoustic output of a native vocal fold mucosa. As used herein, the term bioengineered generally refers to a tissue prepared in vitro using biological techniques including, for example, techniques of cell biology, biochemistry, tissue culture, and materials science.
(20) The following abbreviations and acronyms are used in this application: VF, vocal fold; VFF, vocal fold fibroblasts; VFE, vocal fold epithelial cells; ECM, extracellular matrix.
(21) Each of the publications cited in this application is incorporated by reference in its entirety and for all purposes. While specific embodiments and examples of the disclosed subject matter have been discussed herein, these examples are illustrative and not restrictive. Many variations will become apparent to those skilled in the art upon review of this specification and the claims below.
(22) The following Example is offered for illustrative purposes only, and is not intended to limit the scope of the present invention in any way. Indeed, various modifications of the invention in addition to those shown and described herein will become apparent to those skilled in the art from the foregoing description and the following example and fall within the scope of the appended claims.
EXAMPLE
Bioengineered Vocal Fold Mucosa for Voice Restoration
(23) In this Example, we generated bioengineered vocal fold mucosae from isolated and purified vocal fold fibroblasts (VFF) and epithelial cells (VFE). Specifically, we initially hypothesized that primary human-sourced VF mucosal cells, exposed to unique mechanical forces during human voice production.sup.20,21, could be an appropriate cell source for the development of a bioengineered VF mucosa capable of recapitulating native VF physiologic function. We therefore isolated and purified primary vocal fold fibroblasts (VFF) and epithelial cells (VFE) from individual human donors and cultured these cells under 3D organotypic conditions, based on techniques commonly employed in skin and other mucosal systems.sup.22,23. The resulting engineered mucosae showed morphologic resemblance to native human VF mucosa, proteome-level evidence of active organogenesis/morphogenesis along with emerging ECM complexity, and rudimentary epithelial barrier function in vitro. Using a large animal ex vivo setup, we observed aerodynamic-to-acoustic energy transfer, periodic VF vibratory motion with physiologic mucosal wave travel, and acoustic output that were each indistinguishable from those generated by native tissue. Using a humanized mouse system, we implanted engineered VF mucosal auto- and allografts in vivo and documented robust graft survival with favorable tolerance by the human adaptive immune system. Taken together, these results indicate that the disclosed bioengineered mucosae have the potential to restore voice function in patients with otherwise untreatable VF mucosal disease.
(24) Results
(25) Isolation and Characterization of Primary Cells from Human VF Mucosa.
(26) Primary VF mucosal cell culture is rarely feasible with disease-free tissue from human donors, as elective biopsy carries an unacceptable risk of lamina propria scar formation and dysphonia. For this reason, and because of associated technical challenges, there are no published reports of isolation, purification and primary culture of VFF and VFE from a single human donor. We obtained human tissue from cadavers at autopsy (<6 h post-mortem) and patients undergoing total laryngectomy for indications that did not include laryngeal disease (e.g., hypopharyngeal cancer, dysphagia with otherwise untreatable pulmonary aspiration) and then initially conducted primary explant culture in fibroblast- or epithelial cell-oriented medium. Fibroblast-oriented culture resulted in steady VFF proliferation and successful deletion of non-target cells, yielding a morphologically pure VFF population within 21 d (
(27) To address these issues, we developed an approach to better isolate and purify VFF and VFE from human VF mucosa (
(28) Fibroblasts and epithelial cells exhibit distinct immunomarkers in vivo but share expression of most markers (at different abundances) in vitro..sup.24,25 We therefore used a 6-marker flow cytometry panel to characterize the relative expression of classic fibroblast- and epithelial cell-associated proteins in our adhesion-separated VFF and VFE (
(29) VFF maintained a consistent proliferation rate (30-40 h population doubling time) over 6 passages (
(30) Assembly of 3D Engineered VF Mucosa.
(31) Having successfully identified a viable source of purified human primary cells, we pursued 3D organotypic culture (
(32) The engineered VF mucosa began to resemble native mucosa after 10-14 d in culture, exhibiting a 50 m-thick stratified squamous epithelium and sparsely cell populated lamina propria (
(33) To further characterize the biological complexity of the engineered VF mucosa, we conducted discovery proteomic analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Using a 1% false discovery rate, we identified 762 unique proteins in the engineered mucosa, compared with 908 in the native mucosa and 32 in the collagen, type I-based scaffold (
(34) Quantitative Proteomic Analysis of Engineered VF Mucosa Compared to its Isolated Subcomponents.
(35) We pursued further quantitative proteomic analyses to identify protein complexes and functionality that were unique to the engineered VF mucosa, compared to its isolated subcomponents: VFF in collagen, type I scaffold and VFE on collagen, type I scaffold (
(36) Next, we performed functional enrichment analysis of the protein set that was either exclusively identified or quantitatively overrepresented in engineered VF mucosa compared to both VFF in scaffold and VFE on scaffold. The most highly represented biological process ontology terms (adjusted P<410.sup.5) indicated that the engineered mucosa was uniquely engaged in macromolecule catabolism, protein localization, and cellular component organization or biogenesis (
(37) Emergence of Immature Barrier Function in Engineered VF Mucosa.
(38) As our histologic and proteomic data suggested the emergence of basement membrane structures and epithelial junctional complexes under organotypic culture conditions, we performed follow-up immunovalidation of laminin 5, keratin 5 and junction plakoglobin expression in engineered VF mucosa, and compared the distribution of these proteins to native VF mucosa. Immunohistochemistry confirmed that each of these targets was expressed in the engineered VF epithelium but lacked the region-specific localization of native mucosa (
(39) To further evaluate physiologic barrier function in the engineered mucosa, we conducted transmucosal electrical resistance experiments. These experiments required reducing fibroblast seeding density by 3.5-fold (to 5.610.sup.4 VFF.Math.mL.sup.1) to reduce scaffold contraction and eliminate detachment from the insert wall. Under comparable culture conditions, the engineered mucosa had significantly greater resistance than scaffold only and VFF in scaffold (P<0.01), but showed no significant difference compared to VFE on scaffold (P=0.06;
(40) Ex Vivo Physiologic Function of Engineered VF Mucosa.
(41) Given the favorable morphologic and histologic appearance of engineered VF mucosa compared to native tissue, we scaled-up our engineering approach to create human-sized tissues, and evaluated their physiologic performance in a large animal excised larynx setup. This ex vivo approach holds key methodological advantages over in vivo techniques for studying VF physiology, due to greater control of anatomic, postural and aerodynamic input parameters, direct visual exposure of the VFs during vibration, and more precise multichannel measurement. We used canine larynges based on their anatomic similarity to human specimens and precedence in excised larynx studies.sup.33-35 and collected sequential datasets from each larynx: (i) with bilateral native VFs intact, (ii) following unilateral VF mucosa resection to impair physiologic function, and (iii) following unilateral placement of engineered VF mucosa in an attempt to restore function (
(42) We collected a complete array of aerodynamic, high-speed digital imaging (HSDI) and acoustic data (
(43) HSDI analysis showed restoration of typical vibratory physiology following engineered VF mucosa replacement. Glottal area waveforms and displacement values were similar to those generated by native mucosa, particularly for within-larynx comparisons (P=0.26;
(44) Using the same ex vivo experimental set-up, we next compared the physiologic function of engineered VF mucosa with that of human oral mucosa (
(45) Immunogenicity of Engineered VF Mucosa.
(46) To further evaluate its potential for therapeutic implementation, we tested the immunogenicity of engineered VF mucosa and its constituent cells using flow cytometry and an in vivo transplantation assay. Previous work has shown that primary VFF express a cell-surface phenotype that is comparable to iminunoprivileged mesenchymal stem cells.sup.41, however no such data have been reported for VFE. VFF and VFE uniformly expressed the pan-major histocompatibility complex (MHC) class I marker human leukocyte antigen (HLA)-ABC (common to all nucleated cells), but were negative for the pan-MHC class II marker HLA-DR (associated with professional antigen-presenting cells), as well as the T cell costimulatory molecules CD80 and CD86 (
(47) Given these encouraging in vitro data, we next evaluated in vivo survival and tolerance of engineered VF mucosa following subrenal capsule auto- and allograft transplantation in the humanized NOD-scid IL2r.sup.null (NSG) mouse. This transgenic model contains a targeted mutation causing complete silencing of the interleukin-2 receptor -chain (IL2r) locus, which results in severely restricted B, T, and natural killer (NK) cell development.sup.42. The NSG model supports engraftment of human peripheral blood lymphocytes (hPBL) and establishment of a functional human adaptive immune system, allowing evaluation of graft immunogenicity during the period prior to terminal xenogeneic graft-versus-host disease (GVHD).
(48) We implanted engineered VF mucosal grafts from unrelated human donors under the bilateral renal capsules of irradiated NSG mice, followed by intravenous delivery of 1310.sup.6 hPBL that were obtained from an original laryngeal tissue donor and autologous to one of the two grafts (
(49) The identification of a robust subpopulation of regulatory T cells in the auto- and allografts, combined with the absence of tissue destruction in both conditions, suggests that engineered VF mucosa holds low immunogenicity and is well tolerated by the human adaptive immune system in vivo. Additional long-term experiments in NSG mice without hPBL challenge confirmed that the grafts survived and remained populated by human cells for the entire 70-98 days (d) experimental time course (
(50) Discussion
(51) We have met a series of important milestones towards the development of a fully functioning bioengineered VF mucosa suitable for therapeutic transplantation. These milestones include: concurrent isolation and purification of primary VFF and VFE from individual human donors; 3D organotypic primary culture resulting in recapitulation of key morphologic features and emerging barrier function; confirmation of size scalability; restoration of normal-appearing physiologic vibratory function and acoustic output; and demonstration of tolerance by the human adaptive immune system. The robust biomechanical performance and low immunogenicity of this engineered VF mucosa indicates that our approach could be used to restore voice function in patients with otherwise untreatable VF mucosal impairment or loss.
(52) Although difficult to obtain, and never previously isolated and purified in parallel, we used primary human VFF and VFE as a source of human VFFs and VFEs based on the rationale that these cells are ideally suited for VF mucosal organotypic culture due to their prolonged exposure to phonation-associated mechanical forces in vivo.sup.20,21. This approach was successful, and under permissive conditions the cells engaged in mucosal morphogenesis, contributing to assembly of a functional 3D tissue. Given that primary VF mucosal cells are not currently available for large-scale clinical therapeutics, utilization of alternative cell populations, such as embryonic stem cell derivatives.sup.15, bone marrow-.sup.44-46 or adipose-derived stem cells.sup.16,17,47, or non-VF somatic cells.sup.48, is an attractive future direction. Such cells might be differentiated towards a VF mucosal cell phenotype, and primed for successful VF organotypic culture and transplantation, by exposure to defined tensile and vibratory forces in a laryngeal bioreactor.sup.49-51.
(53) VF vibratory function and mucosal wave travel are highly dependent on tissue viscoelasticity.sup.20, which in turn is a direct function of VFF-secreted ECM composition.sup.29,30. We seeded cells in a relatively simple collagen, type I-based scaffold material, selected for its cytocompatibility.sup.43, high abundance in native human VF mucosa.sup.26, and utility in previous organotypic culture systems.sup.22,23 and tissue engineering applications.sup.43. This initial collagen matrix was augmented by endogenous ECM production by the seeded cells, and the engineered VF mucosa was further strengthened by VFF-driven contraction to the point that it was able to withstand physiologically relevant aerodynamic driving pressures (1-3 kPa) and tissue vibration rates (100-300 Hz) for accumulated time doses of 10-15 min during our ex vivo experiments.
(54) Still, while physiologic function was comparable, the engineered VF mucosa did not show lamina propria fiber complexity equivalent to mature human VF mucosa. This observation is not surprising considering that, during human development, differentiation of the VF lamina propria ECM into a complex structure with depth-dependent fibrous protein distribution begins at postnatal age 2 months and is not complete until at least 13 years (y).sup.52. Extended culture time, phonation-relevant dosing with mechanical forces (as noted above).sup.49-51, and/or the use of more architecturally relevant scaffold materials such as decellularized VF mucosa.sup.53, may provide the additional microenvironmental cues needed to yield even greater maturation in vitro.
(55) The engineered VF mucosa exhibited low immunogenicity when presented to the human adaptive immune system in vivo, suggesting that this primary cell-based approach itself has clinical potential in an allotransplantation scenario. Full development of this approach may require additional orthotopic transplantation experiments, with evaluation of long-term tolerance and physiologic outcomes. These experiments will allow the skilled artisan to determine the optimal nature and length of in vitro organotypic culture prior to transplantation, and the extent to which subsequent in vivo incorporation of host cells and their participation in ongoing ECM remodeling completes the regeneration process.
(56) Free mucosal graft is a technically straightforward procedure in laryngeal reconstruction and, given its limited vascular demand, has high viability.sup.39. Key considerations in determining in vivo outcomes, therefore, may be the relative long-term immunoprivilege of the (primary or non-primary) cells used for organotypic culture, as well as the cumulative impact of the host response and local biomechanical environment on long-term graft remodeling.
(57) In summary, this Example provides a framework for the efficient generation of physiologically relevant and clinically useful bioengineered VF mucosae. Beyond its direct potential for therapeutic use, this approach has application to the development of advanced in vitro model systems for VF mucosal disease modeling and preclinical testing of therapeutic agents.
(58) Materials and Methods
(59) Cell Isolation and Culture.
(60) Human VF mucosae (n=10) were obtained from cadavers at autopsy (<6 h post-mortem) and patients undergoing total laryngectomy with no evidence of VF mucosal disease on routine clinical, endoscopic and radiographic work-up. Procurement was performed with approval of the University of Wisconsin-Madison Health Sciences Institutional Review Board (IRB). Each mucosa was microdissected from its underlying thyroaytenoid muscle, minced with scalpels, and incubated in PBS containing 7.5 mg.Math.mL.sup.1 collagenase, type I (Wako) and 0.5 mg.Math.mL.sup.1 DNase I (Sigma-Aldrich) at 37 C. using 50 Hz agitation for 1 h. Cells released from the ECM were strained through a 40 m filter (BD Biosciences), rinsed and resuspended in fibroblast-oriented medium (DMEM containing 10% FBS and 100 U.Math.mL.sup.1 antibiotic-antimycotic solution; Sigma-Aldrich), seeded on culture plates pre-coated with Earle's balanced salt solution (EBSS) containing 30 g.Math.mL.sup.1 collagen, type I, 10 g.Math.mL.sup.1 fibronectin and 10 g.Math.mL.sup.1 BSA.sup.54, and incubated at 37 C. in 5% CO.sub.2. After 30 min, free-floating non-adherent cells were collected, rinsed in epithelial cell-oriented medium (DMEM/Ham's F-12 supplemented with 15 g.Math.mL.sup.1 bovine pituitary extract, 10 ng.Math.mL.sup.1 epidermal growth factor, 0.5 g.Math.mL.sup.1 epinephrine, 5 g.Math.mL.sup.1 insulin, 10 g.Math.mL.sup.1 transferrin, 10 ng.Math.mL.sup.1 triiodo-L-thyronine, 0.5 g.Math.mL.sup.1 hydrocortisone, 0.1 ng.Math.mL.sup.1 retinoic acid, 1.5 g.Math.mL.sup.1 albumin, 100 U.Math.mL.sup.1 antibiotic-antimycotic solution, and 1% FBS; Sigma-Aldrich).sup.54, reseeded on pre-coated culture plates, and maintained in epithelial cell-oriented culture conditions. Adherent cells were maintained in fibroblast-oriented culture conditions.
(61) Both cell populations were cultured at 37 C. in 5% CO.sub.2 and passaged when 80% confluent. Given that epithelial cells, once attached, are more adherent than fibroblasts in 2D culture, we performed additional adherence-based VFE purification at passages 1 and 2, as follows. Cells were incubated with 0.05% trypsin-EDTA (Sigma-Aldrich) at 37 C. for 1 minute to detach contaminating VFF, rinsed with PBS, and then incubated with 0.25% trypsin-EDTA at 37 C. for 2 min to detach remaining VFE for subsequent passage. Cell passage was performed using 510.sup.3 cells.Math.cm.sup.2 seeding density. Cells intended for fixation and staining were seeded at 1-310.sup.3 cells.Math.cm.sup.2 density on slide chambers.
(62) Cell Growth Kinetics.
(63) Passage 1-6 VFF and VFE (n=4 biological replicates per condition) were plated at 310.sup.5 cells.Math.cm.sup.2 seeding density in 6-well plates and cultured at 37 C. in 5% CO.sub.2. Cells were trypsinized and harvested after 96 hours, stained with trypan blue, and counted. All counts (at the time of cell seeding and harvest) were performed using a hematocytometer in technical quadruplicate. Cell plates were imaged to confirm cell trypsinization and complete detachment. Population doubling time was calculated as 2.sup.N=C.sub.f/C.sub.i, where N denotes doubling time, C.sub.f denotes the final cell count at time of harvest, and C.sub.i denotes the initial cell count at time of seeding.sup.55.
(64) 3D Organotypic Culture.
(65) We engineered 167 VF mucosae using 3D organotypic culture. Purified rat tail collagen, type I (BD Biosciences) was prepared to a final concentration of 2.4 mg.Math.mL.sup.1 according to the manufacturer's instructions and seeded with 210.sup.5 VFF.Math.mL.sup.1. Mucosae used for transmucosal resistance experiments were prepared with a reduced fibroblast seeding density of 5.610.sup.4 VFF.Math.mL.sup.1 to reduce scaffold contraction and eliminate detachment from the insert wall. The cell-scaffold mixture was added to the apical chamber of a culture insert (0.14 mL per well of a 24-well insert with 0.4 m pore size, 0.64 cm diameter, 0.3 cm.sup.2 surface area; or 2.0 mL per well of a 6-well insert with 0.4 m pore size, 2.31 cm diameter, 4.2 cm.sup.2 surface area; BD Biosciences). The collagen-based scaffold was then polymerized at 37 C. for 40 min. Fibroblast-oriented medium was added to both apical and basolateral chambers and the cells were cultured for 24 hours. Next, VFE were seeded on the polymerized scaffold surface within the apical chamber (210.sup.5 VFE per well of a 24-well insert; 210.sup.6 VFE per well of a 6-well insert) and cultured in epithelial cell-oriented medium; a 1:1 ratio of fibroblast- and epithelial cell-oriented media was added to the basolateral chamber. After an additional 48 h, the epithelial cell-oriented medium was aspirated from the apical chamber, leaving VFE at the air-liquid interface. We continued organotypic culture for a total of 8-28 d with basolateral chamber media change every 48 h.
(66) As initial histological assessment showed no difference in engineered VF mucosa morphology at 14 and 28 d, we performed all subsequent histological, immunohistochemical, proteomic, physiologic and immunologic assays on samples harvested at 14 d. Experimental comparisons involving the scaffold only, VFF in scaffold and VFE on scaffold involved identical culture conditions for the entire 14 d period.
(67) Ex Vivo Physiologic Experiments.
(68) Ex vivo physiologic data were collected using a previously reported experimental setup.sup.56. HSDI data were captured at 13,500 frames.Math.s.sup.1 and calibrated for distance measurement in mm. Acoustic data were digitized at 48 kHz with 16-bit quantization. The microphone and sound level meter (dB A-weighted) were positioned 3 cm from the glottal midpoint.
(69) Previously harvested and cryopreserved canine larynges (n=10) were thawed at 4 C. overnight and the epiglottis, aryepiglottic folds and false VFs were removed to maximize visual exposure of the true VFs. Arytenoid adduction procedures were performed using 5-0 sutures. Following instrument calibration, each larynx was mounted and then subjected to gradual increases in P.sub.s to obtain P.sub.th. Aerodynamic, acoustic and HSDI data were then collected at P.sub.th, 1.5P.sub.th and 2P.sub.th. For 5 larynges, data were collected under native conditions, following unilateral VF mucosa resection, and following engineered VF mucosa placement. Additional data were collected in a parallel experiment using the remaining 5 larynges and previously cryopreserved human oral mucosa (n=5; harvested from cadavers at autopsy [<6 h post-mortem] under IRB exemption) in place of the engineered VF mucosa. The engineered VF or oral mucosa was attached to the underlying thyroarytenoid muscle using fibrin sealant (Tisseel; Baxter). All ex vivo tissues were draped with saline-soaked gauze between experimental runs to prevent dehydration.
(70) .sub.ac was derived from acoustic intensity in dB SPL, based on an assumption of uniform acoustic radiation from the glottis in all directions.
.sub.aero was calculated by multiplying P.sub.s in kPa by U in L.Math.s.sup.1. E.sub.g was calculated by dividing
.sub.ac by
.sub.aero (both in W) and converting to a percentage. HSDI-based analyses of glottal area and vibratory phase differences were performed in Matlab (Mathworks) with implementation of previously described algorithms.sup.57-60. Acoustic time-domain plots and narrowband spectrograms (150 ms analysis window) were generated using Praat 5.3.41 (Paul Boersma and David Weenink, University of Amsterdam). Phase plots were generated as previously described.sup.61. Qualitative signal typing was performed using previously reported criteria.sup.36,37.
(71) Humanized Mouse Experiments.
(72) hPBL were obtained with IRB approval and isolated from individuals with no known hematopoietic disorders via either leukapheresis using lymphocyte separation medium (Cellgro) or routine venipuncture with collection in a lavender-top Vacutainer tube (BD Biosciences) followed by centrifugation and separation. All samples were subject to ACK lysis of red blood cells and frozen prior to experimental use.
(73) NOD-scid IL2r.sup.null (NSG) mice aged 7-8 weeks (wk) were used for all in vivo experiments (n=23; Jackson Laboratory); protocols were approved by the University of Wisconsin School of Medicine and Public Health Animal Care and Use Committee. Mice were conditioned with sublethal (2.5 Gy) total body irradiation; 4 h following irradiation, engineered VF mucosae were implanted under the bilateral renal capsules. The following day, mice received an intravenous injection of 1310.sup.6 hPBL that were isolated from an original laryngeal tissue donor and autologous to one of the two engineered VF mucosal grafts. Additional mice were subject to the following conditions: engineered VF mucosal graft implantation followed by delivery of hPBL that were allogeneic to both grafts; engineered VF mucosal graft implantation followed by no hPBL delivery; acellular scaffold implantation followed by hPBL delivery; acellular scaffold implantation followed by no hPBL delivery (n=3-6 per condition).
(74) Mice were monitored every 1-2 d for decrease in body mass and clinical signs consistent with GVHD, such as a hunched posture, ruffled fur, and mobility difficulty: mice who received hPBL were euthanized in response to a >15% decrease in body mass compared to baseline. Other mice were monitored for 70-98 d. Peripheral blood was collected at 7 d post-engraftment and at the experimental endpoint and processed for flow cytometry. Auto- and allografts, acellular scaffolds and eyelids (used as a positive control for xenogeneic GVHD) were harvested at the experimental endpoint and processed for histology and immunohistochemisty.
(75) Flow Cytometry.
(76) Cells were washed and suspended in staining buffer (Hanks' balanced salt solution (HBSS) containing 2% FBS and 10 mM HEPES). For cell surface staining, single cell suspensions were incubated with fluorochrome-conjugated antibodies. For intracellular staining, unstained or surface-stained cells were washed, then fixed and permeabilized using Cytofix/Cytoperm (BD Biosciences) according to the manufacturer's instructions. The permeabilized cells were then incubated with fluorochrome-conjugated antibodies against the intracellular targets, washed, and resuspended in staining buffer. All antibodies are listed in Table 6. Cells were also incubated with DAPI: a change in DAPI fluorescent intensity was used to gate live versus dead cells. Samples were run on a 4-laser, 14-color LSR II instrument (BD Biosciences) and data were analyzed using FlowJo 8.7.1 (Tree Star). We employed both isotype (Table 6) and fluorescence-minus-one (FMO) controls.
(77) Histology, Immunocytochemistry and Immunohistochemistry.
(78) Cells seeded on slide chambers were harvested after 2-3 days in culture and fixed using 2-4% paraformaldehyde. Native and engineered tissues were processed for paraffin (5 m-thick) and frozen (8 m-thick) sections. Routine H&E, Alcian blue (pH 2.5, with and without hyaluronidase digestion), Elastic van Gieson, and Movat's pentachrome histological staining was performed on both paraffin and frozen sections to evaluate morphology.
(79) Frozen sections used for immunostaining were incubated with 0.5% Triton X-100 for 15 min, Image iT-FX (Life Technologies) for 30 min, and Block-Ace (AbD Serotech) and 5% donkey serum (Sigma-Aldrich) for 30 min. Fixed cells and sections were incubated with primary antibodies for 90 min followed by appropriate secondary antibodies for 90 min, with thorough wash steps between each incubation step. A complete list of antibodies is provided in Table 7. Following primary and secondary antibody incubations, cells and sections were counterstained with DAPI, covered with Vectashield antifade mounting medium (Vector Labs), and coverslipped.
(80) Paraffin sections used for immunostaining were first processed for antigen retrieval in a decloaking chamber (Biocare Medical) using 10 mM citrate buffer (pH 6.0). Sections were permeabilized using 0.2% Triton X-100 for 10 minutes and incubated with 10% BSA in PBS for 60 minutes to block non-specific binding, prior to incubation with primary antibodies for 60 minutes (Table 7). Thorough washing was performed between each incubation step. For HRP-based detection, endogenous peroxidase was quenched using 3% hydrogen peroxide in PBS. ImmPRESS anti-mouse and anti-rabbit Ig HRP polymers were used for secondary detection (30 minutes incubation) and the ImmPACT DAB kit was used to develop the signal (all reagents from Vector Labs), according to the manufacturer's instructions. Sections were counterstained with hematoxylin, dehydrated, cleared and coverslipped.
(81) All staining protocols were performed using 5-10 biological replicates, each with two technical replicates. Histological, immunocytochemical and immunohistochemical images were captured using a microscope (E-600; Nikon) equipped with a digital microscopy camera (DP-71; Olympus). Consistent exposure parameters were used for each immunostained protein of interest. Positive control tissues (Table 7) showed expected immunostaining patterns. Negative control sections, stained with an IgG isotype control or without the primary or secondary antibody, showed no immunoreactivity.
(82) Histology- and immunohistochemistry-based cell counts were performed using 10 non-overlapping, high-magnification fields per biological replicate. For measurement of overall cell density in the engineered and native VF mucosae, 0.25 mm.sup.2-sized fields were randomly sampled from the central lamina propria region. For measurement of hCD4.sup.hFOXP3.sup.+ cell density in the VF auto- and allografts, 0.1 mm.sup.2-sized fields were randomly sampled from the deep lamina propria region of each graft (nearest the mouse kidney) as this region contained the greatest number of infiltrating cells. For measurement of hCD4.sup.+hFOXP3.sup.+ cell density in the mouse eyelid, 0.1 mm.sup.2-sized fields were randomly sampled from the meibomian gland-containing region.
(83) Proteomic Analyses.
(84) Proteins were extracted from each sample (n=3 biological replicates per condition) by first adding 150 L of 4% SDS, 0.1 M Tris-HCl (pH 7.6) and 0.1 M dithiothreitol. Next, samples were sonicated (alternating 20 s on/off cycles for 6 min) using a probe sonicator (XL2015 with PN/418 microtip; Misonix), heated to 95 C. for 7 min, and then centrifuged at 16,100 g at 20 C. for 5 min. A 30 L aliquot of the supernatant was processed according to the filter-aided sample preparation (FASP) protocol for SDS removal and on-filter digestion.sup.62,63. Briefly, the supernatant was added to a 30,000 MWCO Vivacon 500 filter (Sartorius), washed, alkylated, and digested with trypsin (50:1 w/w protein-to-trypsin ratio) at 37 C. overnight. The digested sample was desalted using a Sep-Pak C18 1 cc Vac cartridge (Waters), evaporated to dryness in a vacuum centrifuge, and reconstituted in 5% acetonitrile and 2% formic acid in water.
(85) The following mass spectrometry (MS) experiment was performed using two technical replicates per biological replicate. Approximately 1.2 g of the protein digest, as estimated by a BCA assay (Pierce), was injected into a Waters nanoAcquity HPLC coupled to an ESI ion-trap/orbitrap mass spectrometer (LTQ Orbitrap Velos; Thermo Scientific). Peptides were separated on a 100 m-inner-diameter column packed with 20 cm of 3 m MAGIC aqC18 beads (Bruker-Michrom), which were packed against an in-house laser-pulled tip, and eluted at 0.3 L.Math.min.sup.1 in 0.1% formic acid with a gradient of increasing acetonitrile, over 2.5 h. A full-mass scan (300-1500 m/z) was performed in the orbitrap at a resolution of 60,000. The ten most intense peaks were then selected for fragmentation by high-energy collisional dissociation (HCD) at 42% collision energy, with a resolution of 7500 and isolation width of 2.5 m/z. Dynamic exclusion was enabled with a repeat count of 2 over 30 seconds (s) and an exclusion duration of 120 s.
(86) We searched the mass spectra against appropriate organism protein databases (Homo sapiens and Rattus norvegicus; UniProt) using the SEQUEST algorithm within Proteome Discoverer (Thermo Scientific). We allowed two missed cleavages, required at least two unique peptides per protein identification, and filtered the results using a 1% peptide false discovery rate. Precursor mass tolerance was set to 25 ppm and 0.05 Da for fragment ion tolerance. Variable methionine and proline oxidation (+15.995 Da) and static carbamidomethylation of cysteines (+57.021 Da) were also used. Spectral counting-based protein quantification was performed using the normalized spectral abundance factor (NSAF) approach.sup.28. Further normalization, based on an assumption of comparable degradation of rat collagen across experimental conditions, was performed using a correction factor calculated from the NSAF values of the 10 most abundant proteins in the collagen, type I-based scaffold. The raw MS data files may be downloaded from the PeptideAtlas peptide data repository.sup.64 using the dataset identifier PASS00271.
(87) Protein Array.
(88) Passage 3 VFF were seeded at a density of 210.sup.5 cells.Math.mL.sup.1 collagen, type I and cultured at 37 C. in 5% CO.sub.2 for 96 h. Fibroblast-oriented medium was changed every 24 h. Culture supernatants were harvested 48 and 96 h post-seeding, pooled across 6 biological replicates per time point, and processed for measurement of MMP/TIMP concentrations using the Quantibody Human MMP Array 1 platform (RayBiotech), according to the manufacturer's instructions. Medium only was used as a negative control. Each MMP/TIMP of interest was assayed in technical quadruplicate. The array was scanned and data processed using Q-Analyzer software (RayBiotech).
(89) Rheologic Analyses.
(90) Small-amplitude oscillatory shear measurements (n=4-12 biological replicates per condition) were performed in a Bohlin C-VOR rheometer (Malvern) using 15-mm parallel-plate geometry with a 0.3-0.6 mm gap size (adjusted according to the sample volume) at 37 C. Serrated plates were used to avoid sample slippage during testing. Frequency sweep tests were performed from 0.01-10 Hz under a constant applied stress of 3 Pa, which was determined as the linear viscoelastic limit via stress sweep tests.
(91) Transmucosal Electrical Resistance Analyses.
(92) Electrical resistance measurements (n=4 biological replicates per condition, each with two technical replicates) were performed in 24-well inserts using a Millicell-ERS volt-ohm meter (Millipore), according to the manufacturer's instructions. Samples were rinsed and fresh media were added to the basolateral and apical insert chambers 15-30 min prior to data collection. The resistance value of an insert containing fresh media but no scaffold or cells was subtracted from each sample measurement. Resistance values were then further normalized to the scaffold only condition.
(93) Statistical Analyses.
(94) Technical replicates were averaged and all statistical comparisons were performed using independent biological replicates. NSAF-based quantitative proteomic data were analyzed using a two-tailed Student's t test with implementation of Benjamin-Hochberg correction.sup.65 to account for multiple testing. Gene ontology term enrichment analysis was performed using the BiNGO.sup.66 (hypergeometric model with Benjamini-Hochberg correction) and REViGO.sup.67 (SimRel cutoff=0.4) algorithms. Ontology term enrichment schematics were generated using Cytoscape 2.8.2.sup.68. Other statistical testing was performed using SAS 9.2 (SAS Institute). Flow cytometry, rheology (comparison of slopes of each fitted curve), cell density, transmucosal resistance, P.sub.th, and body mass data were analyzed using one-way ANOVA. Glottal area and vibratory phase data were analyzed using two-way ANOVA, with VF mucosa condition and P.sub.th as fixed effects, and their interaction term included. Cell proliferation data were also analyzed using two-way ANOVA, with cell type and culture passage as fixed effects, and their interaction term included. Data were first evaluated for normality and equality of variance using visual inspection of raw data plots and Levene's test; data were rank-transformed where needed to meet the equal variance assumptions of the Student's t test and ANOVA. In all ANOVA models, if the omnibus F test revealed a significant difference, pairwise comparisons were performed using Fisher's protected least significant difference method. Categorical acoustic signal typing data were analyzed using a chi-squared test. An initial (pre-correction) type I error rate of 0.01 was used for all statistical testing; quantitative proteomic data were subject to an additional fold change cutoff of 4. All P-values were two-sided.
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(96) TABLE-US-00001 TABLE 1 Lists of proteins identified in LC-MS/MS analysis of scaffold only, VFF in scaffold, VFE on scaffold, engineered VF mucosa and native VF mucosa. Identifications were based on a 1% false discovery rate. The scaffold was sourced from Rattus norvegicus; VFF, VFE and native VF mucosa were sourced from Homo sapiens. Proteins are listed in order of descending peptide spectra matches. UniProt Sequence Peptide accession coverage Unique spectra number Protein name Gene symbol Organism Score (%) peptides matches Scaffold only P02454 Collagen alpha-1(I) chain COL1A1 Rattus norvegicus 14562.52 74.88 79 16858 P02466 Collagen alpha-2(I) chain COL1A2 Rattus norvegicus 10402.75 69.39 68 8327 P13941 Collagen alpha-1 (III) chain COL3A1 Rattus norvegicus 475.78 11.41 8 456 Q29RW1 Myosin-4 MYH4 Rattus norvegicus 414.90 15.58 15 101 P02770 Serum albumin ALB Rattus norvegicus 285.30 25.99 14 74 P50609 Fibromodulin FMOD Rattus norvegicus 255.20 19.68 5 58 P04937 Fibronectin FN1 Rattus norvegicus 167.39 5.41 9 45 P68035 Actin, alpha cardiac muscle 1 ACTC1 Rattus norvegicus 158.07 19.63 3 39 P60711 Actin, cytoplasmic 1 ACTB Rattus norvegicus 113.85 20.53 3 28 P01026 Complement C3 C3 Rattus norvegicus 89.00 2.53 3 25 Q6IFW6 Keratin, type I cytoskeletal 10 KRT10 Rattus norvegicus 81.38 9.89 5 24 P11517 Hemoglobin subunit beta-2 HBB2 Rattus norvegicus 66.34 40.14 5 23 P00564 Creatine kinase M-type CKM Rattus norvegicus 92.71 20.21 6 22 Q01129 Decorin DCN Rattus norvegicus 78.80 15.25 4 21 P04797 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Rattus norvegicus 42.24 14.71 3 19 P63018 Heat shock cognate 71 kDa protein HSPA8 Rattus norvegicus 70.47 7.59 5 19 Q6IMF3 Keratin, type II cytoskeletal 1 KRT1 Rattus norvegicus 64.27 5.60 3 19 P01946 Hemoglobin subunit alpha-1/2 HBA1 Rattus norvegicus 74.27 35.21 3 17 P47853 Biglycan BGN Rattus norvegicus 50.62 8.94 2 16 P62260 14-3-3 protein epsilon YWHAE Rattus norvegicus 44.11 8.63 2 15 Q68FP1 Gelsolin GSN Rattus norvegicus 49.45 3.85 2 13 Q6P6Q2 Keratin, type II cytoskeletal 5 KRT5 Rattus norvegicus 42.90 4.17 2 13 P04462 Myosin-8 (Fragment) MYH8 Rattus norvegicus 32.58 19.07 2 11 Q9Z1P2 Alpha-actinin-1 ACTN1 Rattus norvegicus 33.89 5.16 4 11 Q62812 Myosin-9 MYH9 Rattus norvegicus 33.15 3.21 5 10 P07335 Creatine kinase B-type CKB Rattus norvegicus 24.32 5.51 2 9 P34058 Heat shock protein HSP 90-beta HSP90AB1 Rattus norvegicus 21.83 5.39 3 7 P48037 Annexin A6 ANXA6 Rattus norvegicus 13.18 4.31 3 5 Q63041 Alpha-1-macroglobulin A1M Rattus norvegicus 20.75 2.27 2 5 P11980 Pyruvate kinase isozymes M1/M2 PKM Rattus norvegicus 17.00 7.53 2 4 B0BNI5 Olfactomedin-like protein 3 OLFML3 Rattus norvegicus 15.93 9.85 2 3 P04642 L-lactate dehydrogenase A chain LDHA Rattus norvegicus 11.00 7.53 2 3 VFF in scaffold P02454 Collagen alpha-1(I) chain COL1A1 Rattus norvegicus 19037.82 70.06 82 23558 P02452 Collagen alpha-1(I) chain COL1A1 Homo sapiens 9435.37 51.91 54 12141 P02466 Collagen alpha-2(I) chain COL1A2 Rattus norvegicus 13087.50 67.49 67 11240 P08123 Collagen alpha-2(I) chain COL1A2 Homo sapiens 3527.28 43.70 37 3038 Q09666 Neuroblast differentiation-associated protein AHNAK Homo sapiens 3901.70 45.53 121 1159 AHNAK P02751 Fibronectin FN1 Homo sapiens 2589.18 36.92 59 665 P12111 Collagen alpha-3(VI) chain COL6A3 Homo sapiens 1935.31 24.99 59 587 P21333 Filamin-A FLNA Homo sapiens 2125.93 37.97 65 524 P08670 Vimentin VIM Homo sapiens 1767.03 59.23 34 518 P60711 Actin, cytoplasmic 1 ACTB Rattus norvegicus 1522.82 63.20 16 411 P35579 Myosin-9 MYH9 Homo sapiens 1580.80 37.96 56 396 P12109 Collagen alpha-1(VI) chain COL6A1 Homo sapiens 901.30 23.35 15 378 P14618 Pyruvate kinase PKM PKM Homo sapiens 1333.05 59.70 26 356 P07355 Annexin A2 ANXA2 Homo sapiens 1335.76 58.11 20 350 Q15149 Plectin PLEC Homo sapiens 1144.56 19.75 69 329 P02545 Prelamin-A/C [Cleaved into: Lamin-A/C] LMNA Homo sapiens 1094.53 54.67 35 326 P02458 Collagen alpha-1(II) chain COL2A1 Homo sapiens 430.06 7.87 5 305 P07437 Tubulin beta chain TUBB Homo sapiens 1015.36 66.89 21 281 Q00610 Clathrin heavy chain 1 CLTC Homo sapiens 1081.13 27.22 36 268 O43707 Alpha-actinin-4 ACTN4 Homo sapiens 1000.62 51.37 36 265 P68371 Tubulin beta-4B chain TUBB4B Homo sapiens 967.12 66.74 21 262 P11021 78 kDA glucose-regulated protein HSPA5 Homo sapiens 866.31 33.33 18 250 P08238 Heat Shock protein HSP 90-beta HSP90AB1 Homo sapiens 880.50 33.01 18 238 P11142 Heat shock cognate 71 kDa protein HSPA8 Homo sapiens 853.97 39.01 22 236 P04408 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Homo sapiens 790.07 46.87 12 235 Q13885 Tubulin beta-2A chain TUBB2A Homo sapiens 780.66 56.63 18 221 P15144 Aminopeptidase N ANPEP Homo sapiens 776.75 25.54 23 217 P13941 Collagen alpha-1(III) chain COL3A1 Rattus norvegicus 235.58 12.03 11 217 P12814 Alpha-actinin-1 ACTN1 Homo sapiens 771.27 36.77 27 215 P68363 Tubulin alpha-1B chain TUBA1B Homo sapiens 753.76 50.55 18 215 Q13509 Tubulin beta-3 chain TUBB3 Homo sapiens 668.44 36.89 14 201 P00558 Phosphoglycerate kinase 1 PGK1 Homo sapiens 755.19 52.04 17 199 P04083 Annexin A1 ANXA1 Homo sapiens 758.14 52.60 16 192 P68104 Elongation factor 1-alpha 1 EEF1A1 Homo sapiens 761.73 33.98 11 188 P68035 Actin, alpha cardiac muscle 1 ACTC1 Rattus norvegicus 611.13 32.89 10 188 P07900 Heat shock protein HSP 90-alpha HSP90AA1 Homo sapiens 649.34 21.31 12 183 P05539 Collagen alpha-1(II) chain COL2A1 Rattus norvegicus 293.86 5.50 4 177 Q9Y490 Talin-1 TLN1 Homo sapiens 638.77 19.91 31 168 P06576 ATP synthase subunit beta, mitochondrial ATP5B Homo sapiens 584.55 39.89 14 161 P06733 Alpha-enolase ENO1 Homo sapiens 521.99 39.86 13 147 P14625 Endoplasmin HSP90B1 Homo sapiens 515.39 25.28 15 144 P08758 Annexin A5 ANXA5 Homo sapiens 478.42 55.31 15 141 Q14764 Major vault protein MVP Homo sapiens 443.98 31.35 19 132 P50454 Serpin H1 SERPINH1 Homo sapiens 533.29 41.15 13 131 P04264 Keratin, type II cytoskeletal 1 KRT1 Homo sapiens 429.54 28.88 18 125 P07585 Decorin DCN Homo sapiens 397.67 43.18 12 123 Q9BUF5 Tubulin beta-6 chain TUBB6 Homo sapiens 397.03 33.86 13 122 P46940 Ras GTPase-activating-like protein IQGAP1 IQGAP1 Homo sapiens 441.43 19.01 21 121 P62805 Histone H4 HIST1H4A Homo sapiens 385.21 51.46 6 116 P04075 Fructose-bisphosphate aldolase A ALDOA Homo sapiens 494.95 57.69 14 114 O43852 Calumenin CALU Homo sapiens 447.18 44.76 14 114 O60814 Histone H2B type 1-K HIST1H2BK Homo sapiens 314.19 34.92 4 112 P08133 Annexin A6 ANXA6 Homo sapiens 404.62 33.73 18 111 P11216 Glycogen phosphorylase, brain form PYGB Homo sapiens 415.67 28.23 19 110 P62937 Peptidyl-prolyl cis-trans isomerase A PPIA Homo sapiens 393.57 55.76 9 110 Q07065 Cytoskeleton-associated protein 4 CKAP4 Homo sapiens 378.99 38.70 18 105 P63104 14-3-3 protein zeta/delta YWHAZ Homo sapiens 352.91 37.14 8 103 Q14315 Filamin-C FLNC Homo sapiens 456.37 11.12 18 101 P07237 protein disulfide-isomerase P4HB Homo sapiens 383.52 35.63 15 101 P00338 L-lactate dehydrogenase A chain LDHA Homo sapiens 340.74 37.95 11 101 P13639 Elongation factor 2 EEF2 Homo sapiens 332.84 28.90 21 101 P18669 Phosphoglycerate mutase 1 PGAM1 Homo sapiens 324.02 44.88 9 99 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD Homo sapiens 375.31 27.57 10 98 P67936 Tropomyosin alpha-4 chain TPM4 Homo sapiens 340.33 47.58 13 98 P60174 Triosephosphate isomerase TPI1 Homo sapiens 367.86 61.19 12 97 P12110 Collagen alpha-2(VI) chain COL6A2 Homo sapiens 329.15 22.37 17 96 P18206 Vinculin VCL Homo sapiens 294.56 26.81 21 94 Q06830 Peroxiredoxin-1 PRDX1 Homo sapiens 397.52 52.26 9 93 Q6NZI2 Polymerase I and transcript release factor PTRF Homo sapiens 339.44 28.21 9 92 P10809 60 kDa heat shock protein, mitochondrial HSPD1 Homo sapiens 336.47 28.27 13 91 P25705 ATP synthase subunit alpha, mitochondrial ATP5A1 Homo sapiens 321.89 20.43 8 91 P08107 Heat shock 70 kDa protein 1A/1B HSPA1A Homo sapiens 300.85 25.12 11 87 P62260 14-3-3 protein epsilon YWHAE Rattus norvegicus 264.94 40.00 8 87 P06396 Gelsolin GSN Homo sapiens 359.55 21.10 12 86 P27348 14-3-3 protein theta YWHAQ Homo sapiens 294.97 38.37 7 86 P30101 Protein disulfide-isomerase A3 PDIA3 Homo sapiens 293.81 28.12 11 86 Q99536 Synaptic vesicle membrane protein VAT-1 VAT1 Homo sapiens 294.87 29.77 7 85 homolog P23284 Peptidyl-prolyl cis-trans isomerase B PPIB Homo sapiens 268.90 40.28 9 85 O00299 Chloride intracellular channel protein 1 CLIC1 Homo sapiens 342.42 63.90 11 84 P09382 Galectin-1 LGALS1 Homo sapiens 300.65 46.67 5 84 P02768 Serum albumin ALB Homo sapiens 319.64 6.73 4 83 P55072 Transitional endoplasmic reticulum ATPase VCP Homo sapiens 344.40 26.30 14 82 P29401 Transketolase TKT Homo sapiens 331.79 28.09 12 81 P13489 Ribonuclease inhibitor RNH1 Homo sapiens 320.57 33.84 10 80 P02461 Collagen alpha-1(III) chain COL3A1 Homo sapiens 119.06 9.75 9 77 Q13813 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Homo sapiens 287.37 12.46 21 76 Q16555 Dihydropyrimidinase-ralated protein 2 DPYSL2 Homo sapiens 285.66 35.14 12 74 P38646 Stress-70 protein, mitochondrial HSPA9 Homo sapiens 275.92 17.23 9 74 Q04628 Aldo-keto reductase family 1 member C1 AKR1C1 Homo sapiens 282.79 35.91 8 73 Q9NZN4 EH domain-containing protein 2 EHD2 Homo sapiens 275.71 38.31 15 73 P27797 Calreticulin CALR Homo sapiens 295.72 37.41 9 72 P63244 Guanine nucleotide-binding protein subunit GNB2L1 Homo sapiens 254.12 55.84 11 72 Q99715 Collagen alpha-1(XII) chain COL12A1 Homo sapiens 251.62 8.23 18 72 P49368 T-complex protein 1 subunit gamma CCT3 Homo sapiens 251.20 29.17 11 72 P53396 ATP-citrate synthase ACLY Homo sapiens 254.08 16.71 12 71 P07195 L-lactate dehydrogenase B chain LDHB Homo sapiens 228.06 37.43 10 70 P49327 Fatty acid synthase FASN Homo sapiens 276.72 11.87 18 69 P23528 Cofilin-1 CFL1 Homo sapiens 283.28 56.02 8 68 Q14204 Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Homo sapiens 240.66 6.03 21 67 P51149 Ras-related protein Rab-7a RAB7A Homo sapiens 226.35 47.83 9 66 P09211 Glutathione S-transferase P GSTP1 Homo sapiens 284.60 48.57 6 65 P02765 Alpha-2-HS-glycoprotein AHSG Homo sapiens 248.58 5.45 3 64 O60664 Perilipin-3 PLIN3 Homo sapiens 227.81 30.88 8 62 P37802 Transgelin-2 TAGLN2 Homo sapiens 217.26 41.21 7 59 P21980 Protein-glutamine gamma-glutamyltransferase 2 TGM2 Homo sapiens 200.88 13.54 6 58 P08865 40S ribosomal protein SA RPSA Homo sapiens 228.76 31.86 7 57 Q03135 Caveolin-1 CAV1 Homo sapiens 206.84 63.48 9 57 P40926 Malate dehydrogenase, mitochondrial MDH2 Homo sapiens 223.19 36.68 9 56 P27824 Calnexin CANX Homo sapiens 209.31 15.37 6 56 P60660 Myosin light polypeptide 6 MYL6 Homo sapiens 179.26 39.07 5 56 P11766 Alcohol dehydrogenase class-3 ADH5 Homo sapiens 256.32 22.99 6 55 P31946 14-3-3 protein beta/alpha YWHAB Homo sapiens 197.15 28.46 5 55 P04792 Heat Shock protein beta-1 HSPB1 Homo sapiens 193.74 49.76 7 55 P07737 Profilin-1 PFN1 Homo sapiens 166.70 63.57 7 55 P21796 Voltage-dependent anion-selective channel VDAC1 Homo sapiens 235.02 27.21 6 54 protein 1 P05387 60S acidic ribosomal protein P2 RPLP2 Homo sapiens 228.69 69.57 4 54 P16152 Carbonyl reductase [NADPH] 1 CBR1 Homo sapiens 227.14 41.16 7 54 P05388 60S acidic ribosomal protein P0 RPLP0 Homo sapiens 222.31 35.02 7 54 Q9H299 SH3 domain-binding glutamic acid-rich-like SH3BGRL3 Homo sapiens 199.84 31.18 3 54 protein 3 Q15084 Protein disulfide-isomerase A6 PDIA6 Homo sapiens 196.61 32.50 9 54 O75083 WD repeat-containing protein 1 WDR1 Homo sapiens 275.17 26.57 8 53 P17301 Integrin alpha-2 ITGA2 Homo sapiens 197.72 11.52 9 53 P46821 Microtubule-associated protein 1B MAP1B Homo sapiens 180.13 9.08 14 52 P61158 Actin-related protein 3 ACTR3 Homo sapiens 222.55 37.80 10 51 P26038 Moesin MSN Homo sapiens 180.77 19.83 12 51 P35237 Serpin B6 SERPINB6 Homo sapiens 176.70 26.06 8 51 P35908 Keratin, type II cytoskeletal 2 epidermal KRT2 Homo sapiens 168.33 22.54 11 51 P00387 NADH-cytochrome b5 reductase 3 CYB5R3 Homo sapiens 188.27 31.56 7 50 P61981 14-3-3 protein gamma YWHAG Homo sapiens 172.74 24.70 5 50 Q15365 Poly(rC)-binding protein 1 PCBP1 Homo sapiens 172.07 32.02 6 50 P13645 Keratin, type I cytoskeletal 10 KRT10 Homo sapiens 165.38 29.28 12 50 Q14697 Neutral alpha-glucosidase AB GANAB Homo sapiens 234.90 10.59 6 49 Q01082 Spectrin beta chain, non-erythrocytic 1 SPTBN1 Homo sapiens 162.63 10.24 16 49 Q9NZM1 Myoferlin MYOF Homo sapiens 184.03 9.70 13 48 P22314 Ubiquitin-like modifier-activating enzyme 1 UBA1 Homo sapiens 182.43 15.03 11 48 Q01518 Adenylyl cyclase-associated protein 1 CAP1 Homo sapiens 174.85 17.47 7 48 Q15019 Septin-2 41884 Homo sapiens 171.34 38.23 8 48 P22626 Heterogeneous nuclear ribonucleoproteins HNRNPA2B1 Homo sapiens 156.70 20.11 6 48 A2/B1 P23396 40S ribosomal protein S3 RPS3 Homo sapiens 139.84 38.68 8 48 P04843 Dolichyl-diphosphooligosaccharide-protein RPN1 Homo sapiens 185.20 23.56 9 47 glycosyltransferase subunit 1 Q96AG4 Leucine-rich repeat-containing protein 59 LRRC59 Homo sapiens 172.33 23.45 5 47 P21810 Biglycan BGN Homo sapiens 183.82 28.80 9 46 P61978 Heterogeneous nuclear ribonucleoprotein K HNRNPK Homo sapiens 175.85 28.08 9 46 P61204 ADP-ribosylation factor 3 ARF3 Homo sapiens 150.47 38.67 6 46 P30050 60S ribosomal protein L12 RPL12 Homo sapiens 168.79 54.55 6 45 P30086 Phosphatidylethanolamine-binding protein 1 PEBP1 Homo sapiens 155.97 50.27 5 45 P26641 Elongation factor 1-gamma EEF1G Homo sapiens 164.58 21.97 7 44 P12882 Myosin-1 MYH1 Homo sapiens 160.33 8.92 12 44 P62241 40S ribosomal protein S8 RPS8 Homo sapiens 149.78 32.69 5 44 P62424 60S ribosomal protein L7a RPL7A Homo sapiens 144.33 18.42 5 44 Q96D15 Reticulocalbin-3 RCN3 Homo sapiens 177.77 21.95 4 43 P36578 60S ribosomal protein L4 RPL4 Homo sapiens 136.85 13.35 5 43 P30041 Peroxiredoxin-6 PRDX6 Homo sapiens 134.28 41.07 8 43 Q92928 Putative Ras-related protein Rab-1C RAB1C Homo sapiens 129.95 22.89 4 43 P04844 Dolichyl-diphosphooligosaccharide--protein RPN2 Homo sapiens 175.85 29.64 10 42 glycosyltransferase subunit 2 P17655 Calpain-2 catalytic subunit CAPN2 Homo sapiens 161.98 17.43 8 42 P00367 Glutamate dehydrogenase 1, mitochondrial GLUD1 Homo sapiens 157.44 25.63 10 42 P49748 Very long-chain specific acyl-CoA ACADVL Homo sapiens 156.86 21.07 9 42 dehydrogenase, mitochondrial P07339 Cathepsin D CTSD Homo sapiens 146.93 20.63 6 42 P09525 Annexin A4 ANXA4 Homo sapiens 135.76 31.03 8 42 Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP10 FKBP10 Homo sapiens 133.36 11.86 5 42 Q9GZV4 Eukaryotic translation initiation factor 5A-2 EIF5A2 Homo sapiens 164.28 19.61 3 41 P40939 Trifunctional enzyme subunit alpha, HADHA Homo sapiens 159.99 17.96 8 41 mitochondrial O60701 UDP-glucose 6-dehydrogenase UGDH Homo sapiens 145.28 25.71 9 41 P02538 Keratin, type II cytoskeletal 6A KRT6A Homo sapiens 139.17 26.77 13 41 P18085 ADP-ribosylation factor 4 ARF4 Homo sapiens 122.95 48.89 8 41 P24534 Elongaton factor 1-beta EEF1B2 Homo sapiens 172.02 20.44 3 40 P68871 Hemoglobin subunit beta HBB Homo sapiens 134.50 38.78 5 40 P50990 T-complex protein 1 subunit theta CCT8 Homo sapiens 134.31 16.97 7 40 P12236 ADP/ATP translocase 3 SLC25A6 Homo sapiens 112.19 27.85 8 40 P09972 Fructose-bisphosphate aldolase C ALDOC Homo sapiens 171.14 18.41 4 38 P22392 Nucleoside diphosphate kinase B NME2 Homo sapiens 130.86 34.21 4 38 P60842 Eukaryotic initiation factor 4A-I EIF4A1 Homo sapiens 119.34 13.30 4 38 P05141 ADP/ATP translocase 2 SLC25A5 Homo sapiens 107.37 28.19 8 38 P04080 Cystatin-B CSTB Homo sapiens 150.19 45.92 3 37 P62158 Calmodulin CALM1 Homo sapiens 149.55 29.53 4 37 P52209 6-phosphogluconate dehydrogenase, PGD Homo sapiens 146.06 18.22 6 37 decarboxylating P01033 Metalloproteinase inhibitor 1 TIMP1 Homo sapiens 145.27 28.02 4 37 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 Homo sapiens 126.64 9.02 8 37 Q07020 60S ribosomal protein L18 RPL18 Homo sapiens 112.50 30.85 5 37 P60033 CD81 antigen CD81 Homo sapiens 193.33 25.00 3 36 P07858 Cathepsin B CTSB Homo sapiens 176.56 23.60 5 36 Q9Y678 Coatomer subunit gamma-1 COPG1 Homo sapiens 151.53 10.41 6 36 P52907 F-actin-capping protein subunit alpha-1 ALB Homo sapiens 138.39 34.62 6 36 P19105 Myosin regulatory light chain 12A CAPZA1 Homo sapiens 134.09 39.18 5 36 P21589 5-nucleotidase MYL12A Homo sapiens 125.92 18.82 8 36 Q96KK5 Histone H2A type 1-H NT5E Homo sapiens 123.16 27.34 3 36 P50995 Annexin A11 HIST1H2AH Homo sapiens 121.26 15.84 6 36 Q969G5 Protein kinase C delta-binding protein ANXA11 Homo sapiens 119.53 25.29 6 36 P52565 Rho GDP-dissociation inhibitor 1 PRKCDBP Homo sapiens 117.26 21.08 4 36 P45880 Voltage-dependent anion-selective channel ARHGDIA Homo sapiens 111.78 18.03 4 36 protein 2 Q96CX2 BTB/POZ domain-containing protein KCTD12 VDAC2 Homo sapiens 111.07 14.77 4 36 P02770 Serum albumin KCTD12 Rattus norvegicus 139.43 5.92 3 36 P62979 Ubiquitin-40S ribosomal protein S27a RPS27A Homo sapiens 119.99 33.97 4 35 P40925 Malate dehydrogenase, cytoplasmic MDH1 Homo sapiens 115.14 25.15 6 35 P05556 Integrin beta-1 ITGB1 Homo sapiens 114.15 9.77 6 35 P50395 Rab GDP dissociation inhibitor beta FMOD Homo sapiens 126.73 21.35 6 34 P61247 40S ribosomal protein S3a GDI2 Homo sapiens 116.67 18.18 4 34 P07384 Calpain-1 catalytic subunit RPS3A Homo sapiens 114.52 7.56 4 34 P10599 Thioredoxin CAPN1 Homo sapiens 111.79 22.86 2 34 P36955 Pigment epithelium-derived factor TXN Homo sapiens 111.21 11.96 4 34 P07910 Heterogeneous nuclear ribonucleoproteins SERPINF1 Homo sapiens 96.99 13.07 4 34 C1/C2 P50609 Fibromodulin HNRNPC Rattus norvegicus 129.65 11.17 3 34 P62906 60S ribosomal protein L10a RPL10A Homo sapiens 130.04 25.81 4 33 P62888 60S ribosomal protein L30 RPL30 Homo sapiens 113.47 34.78 3 33 P51884 Lumican LUM Homo sapiens 107.66 24.56 6 33 Q16658 Fascin FSCN1 Homo sapiens 128.33 17.04 7 32 Q01813 6-phosphofructokinase type C PFKP Homo sapiens 126.94 10.46 5 32 P69905 Hemoglobin subunit alpha HBA1; Homo sapiens 124.85 28.17 3 32 P04216 Thy-1 membrane glycoprotein THY1 Homo sapiens 121.63 24.22 3 32 P14314 Glucosidase 2 subunit beta PRKCSH Homo sapiens 120.87 9.85 4 32 P23219 Prostaglandin G/H synthase 1 PTGS1 Homo sapiens 120.15 12.85 5 32 Q15293 Reticulocalbin-1 RCN1 Homo sapiens 118.65 22.36 4 32 P04899 Guanine nucleotide-binding protein G(i) GNAI2 Homo sapiens 117.69 20.28 5 32 subunit alpha-2 P78417 Glutathione S-transferase omega-1 GSTO1 Homo sapiens 97.78 19.92 4 32 P55209 Nucleosome assembly protein 1-like 1 NAP1L1 Homo sapiens 125.54 14.58 4 31 P62701 40S ribosomal protein S4, X isoform RPS4X Homo sapiens 116.91 25.10 5 31 P12956 X-ray repair cross-complementing protein 6 XRCC6 Homo sapiens 94.21 12.32 6 31 Q16851 UTP--glucose-1-phosphate uridylyltransferase UGP2 Homo sapiens 154.66 12.60 4 30 P06744 Glucose-6-phosphate isomerase GPI Homo sapiens 127.61 17.74 5 30 Q9Y696 Chloride intracellular channel protein 4 CLIC4 Homo sapiens 122.96 40.32 7 30 P30153 Serine/threonine-protein phosphatase 2A 65 kDa PPP2R1A Homo sapiens 116.53 19.52 7 30 regulatory subunit A alpha isoform Q9NQC3 Reticulon-4 RTN4 Homo sapiens 105.15 9.65 6 30 P34932 Heat shock 70 kDa protein 4 HSPA4 Homo sapiens 97.65 12.86 7 30 Q15366 Poly(rC)-binding protein 2 PCBP2 Homo sapiens 96.66 14.79 4 30 P83731 60S ribosomal protein L24 DCN Homo sapiens 90.70 20.38 3 30 P62249 40S ribosomal protein S16 RPL24 Homo sapiens 85.51 22.60 3 30 Q01129 Decorin RPS16 Rattus norvegicus 90.83 22.60 7 30 P07108 Acyl-CoA-binding protein DBI Homo sapiens 129.14 50.57 3 29 P29373 Cellular retinoic acid-binding protein 2 CRABP2 Homo sapiens 126.14 34.78 4 29 P09651 Heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 Homo sapiens 110.16 30.11 8 29 P16070 CD44 antigen CD44 Homo sapiens 108.92 3.77 2 29 O43390 Heterogeneous nuclear ribonucleoprotein R HNRNPR Homo sapiens 103.11 9.79 5 29 P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 Homo sapiens 99.86 17.20 5 29 P39019 40S ribosomal protein S19 RPS19 Homo sapiens 84.77 35.86 7 29 P07686 Beta-hexosaminidase subunit beta HEXB Homo sapiens 78.39 7.55 4 29 Q04446 1,4-alpha-glucan-branching enzyme GBE1 Homo sapiens 126.14 16.95 7 28 P62829 60S ribosomal protein L23 RPL23 Homo sapiens 103.56 25.00 7 28 P10909 Clusterin CLU Homo sapiens 97.80 14.03 4 28 P55786 Puromycin-sensitive aminopeptidase C3 Homo sapiens 86.55 5.98 5 28 P00505 Aspartate aminotransferase, mitochondrial NPEPPS Homo sapiens 84.77 11.40 4 28 P01026 Complement C3 [Cleaved into: Complement GOT2 Rattus norvegicus 90.69 1.74 2 28 C3 beta chain; Complement C3 alpha chain] P35527 Keratin, type I cytoskeletal 9 KRT9 Homo sapiens 117.56 25.36 10 27 P13667 Protein disulfide-isomerase A4 PDIA4 Homo sapiens 109.73 12.25 5 27 P50991 T-complex protein 1 subunit delta CCT4 Homo sapiens 108.02 10.95 4 27 Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU Homo sapiens 96.33 12.97 6 27 P30044 Peroxiredoxin-5, mitochondrial PRDX5 Homo sapiens 89.27 26.17 4 27 P07602 Proactivator polypeptide [Cleaved into: PSAP Homo sapiens 78.87 10.31 5 27 Saposin-A] P20810 Calpastatin CAST Homo sapiens 119.50 10.88 4 26 P17931 Galeciin-3 LGALS3 Homo sapiens 98.39 15.20 3 26 P22105 Tenascin-X TNXB Homo sapiens 96.39 4.17 8 26 P60903 Protein S100-A10 S100A10 Homo sapiens 95.99 17.53 2 26 P62277 40S ribosomal protein S13 RPS13 Homo sapiens 93.59 17.88 2 26 P23634 Plasma membrane calcium-transporting ATP2B4 Homo sapiens 93.32 6.29 5 26 ATPase 4 P32119 Peroxiredoxin-2 PRDX2 Homo sapiens 89.25 14.65 3 26 P46782 40S ribosomal protein S5 [Cleaved into: 40S RPS5 Homo sapiens 87.53 13.73 2 26 ribosomal protein S5, N-terminally processed] P19823 Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2 Homo sapiens 86.44 3.91 3 26 Q14974 Importin subunit beta-1 KPNB1 Homo sapiens 82.63 13.70 8 26 P53618 Coatomer subunit beta COPB1 Homo sapiens 81.46 12.38 8 26 P31949 Protein S100-A11 S100A11 Homo sapiens 73.32 25.71 3 26 P59998 Actin-related protein 2/3 complex subunit 4 ARPC4 Homo sapiens 71.67 17.86 3 26 Q7KZF4 Staphylococcal nuclease domain-containing SND1 Homo sapiens 100.24 8.35 5 25 protein 1 P18124 60S ribosomal protein L7 RPL7 Homo sapiens 89.60 16.13 3 25 Q12797 Aspartyl/asparaginyl beta-hydroxylase ASPH Homo sapiens 83.42 10.55 5 25 Q8NBS9 Thioredoxin domain-containing protein 5 TXNDC5 Homo sapiens 111.81 9.26 3 24 P47756 F-actin-capping protein subunit beta CAPZB Homo sapiens 97.32 17.33 3 24 P47755 F-actin-capping protein subunit alpha-2 CAPZA2 Homo sapiens 93.19 28.67 5 24 P06748 Nucleophosmin NPM1 Homo sapiens 88.64 12.24 3 24 P15531 Nucleoside diphosphate kinase A NME1 Homo sapiens 82.11 33.55 4 24 P01024 Complement C3 C3 Homo sapiens 79.98 2.47 3 24 P53621 Coatomer subunit alpha COPA Homo sapiens 76.36 7.76 7 24 O75915 PRA1 family protein 3 ARL6IP5 Homo sapiens 71.25 15.96 2 24 Q15582 Transforming growth factor-beta-induced TGFBI Homo sapiens 71.03 7.91 4 24 protein ig-h3 P60981 Destrin DSTN Homo sapiens 67.90 25.45 4 24 P02774 Vitamin D-binding protein GC Homo sapiens 116.41 6.33 2 23 P62263 40S ribosomal protein S14 RPS14 Homo sapiens 90.99 27.81 3 23 P63010 AP-2 complex subunit beta AP2B1 Homo sapiens 87.06 8.54 5 23 O43399 Tumor protein D54 TPD52L2 Homo sapiens 85.22 24.27 3 23 P62826 GTP-binding nuclear protein Ran RAN Homo sapiens 82.88 22.69 4 23 P61106 Ras-related protein Rab-14 RAB14 Homo sapiens 82.68 25.58 3 23 P08134 Rho-related GTP-binding protein RhoC RHOC Homo sapiens 78.51 26.94 4 23 P17980 26S protease regulatory subunit 6A PSMC3 Homo sapiens 76.14 17.08 5 23 P62879 Guanine nucleotide-binding protein GNB2 Homo sapiens 69.24 15.59 5 23 G(I)/G(S)/G(T) subunit beta-2 Q13838 Spliceosome RNA helicase DDX39B DDX39B Homo sapiens 68.43 10.51 4 23 P02533 Keratin, type I cytoskeletal 14 KRT14 Homo sapiens 64.86 17.80 9 23 O75390 Citrate synthase, mitochondrial CS Homo sapiens 63.78 10.09 4 23 Q92743 Serine protease HTRA1 HTRA1 Homo sapiens 61.31 8.75 4 23 P62269 40S ribosomal protein S18 RPS18 Homo sapiens 60.45 16.45 3 23 Q07021 Complement component 1 Q subcomponent- C1QBP Homo sapiens 94.64 12.06 3 22 binding protein mitochondrial P62244 40S ribosomal protein S15a RPS15A Homo sapiens 93.74 24.62 3 22 P13693 Translationally-controlled tumor protein TPT1 Homo sapiens 82.09 12.21 2 22 O60506 Heterogeneous nuclear ribonucleoprotein Q SYNCRIP Homo sapiens 80.19 13.16 6 22 Q00325 Phosphate carrier protein, mitochondrial SLC25A3 Homo sapiens 75.91 14.64 4 22 P78527 DNA-dependent protein kinase catalytic PRKDC Homo sapiens 74.42 2.06 6 22 subunit P15880 40S ribosomal protein S2 RPS2 Homo sapiens 71.50 16.04 4 22 Q96TA1 Niban-like protein 1 FAM129B Homo sapiens 70.01 9.79 5 22 P62857 40S ribosomal protein S28 RPS28 Homo sapiens 69.54 33.33 2 22 P02788 Lactotransferrin LTF Homo sapiens 61.38 4.23 3 22 P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Homo sapiens 87.52 29.63 3 21 P15559 NAD(P)H dehydrogenase [quinone] 1 NQO1 Homo sapiens 81.73 13.50 3 21 O00159 Unconventional myosin-lc MYO1C Homo sapiens 69.32 8.18 6 21 Q9BSJ8 Extended synaptotagmin-1 ESYT1 Homo sapiens 66.23 8.70 7 21 P02787 Serotransferrin TF Homo sapiens 66.03 16.76 8 21 Q8WUM4 Programmed cell death 6-interacting protein PDCD6IP Homo sapiens 64.27 7.49 4 21 P17967 T-complex protein 1 subunit alpha TCP1 Homo sapiens 61.00 10.79 5 21 P16403 Histone H1.2 HIST1H1C Homo sapiens 57.53 15.49 3 21 P05386 60S acidic ribosomal protein P1 RPLP1 Homo sapiens 110.45 57.02 3 20 P68036 Ubiquitin-conjugating enzyme E2 L3 UBE2L3 Homo sapiens 92.04 35.71 3 20 P25396 40S ribosomal protein S12 RPS12 Homo sapiens 84.49 31.82 3 20 P31943 Heterogeneous nuclear ribonucleoprotein H HNRNPH1 Homo sapiens 76.64 10.02 3 20 Q99623 Prohibitin-2 PHB2 Homo sapiens 76.40 16.72 4 20 Q07954 Prolow-density lipoprotein receptor-related LRP1 Homo sapiens 75.28 2.13 6 20 protein 1 P12955 Xaa-Pro dipeptidase PEPD Homo sapiens 74.39 8.32 3 20 O95782 AP-2 complex subunit alpha-1 AP2A1 Homo sapiens 71.27 5.94 4 20 P56134 ATP synthase subunit f, mitochondrial ATP5J2 Homo sapiens 61.83 25.53 2 20 P26447 Protein S100-A4 S-100A4 Homo sapiens 61.18 28.71 3 20 P08779 Keratin, type I cyloskeletal 16 KRT16 Homo sapiens 54.25 15.01 8 20 P78371 T-complex protein 1 subunit beta CCT2 Homo sapiens 81.92 17.01 6 19 P62140 Serine/threonine-protein phosphatase PP1- PPP1CB Homo sapiens 67.52 21.41 6 19 beta catalytic subunit P29692 Elongation factor 1-delta EEF1D Homo sapiens 61.11 17.08 3 19 P46783 40S ribosomal protein S10 RPS10 Homo sapiens 58.94 14.55 2 19 P19338 Nucleolin NCL Homo sapiens 58.45 9.30 5 19 P13797 Plastin-3 PLS3 Homo sapiens 56.74 16.67 8 19 Q6NXT2 Histone H3.3C H3F3C Homo sapiens 54.28 11.85 2 19 P35606 Coatomer subunit beta' COPB2 Homo sapiens 52.01 10.82 7 19 P46781 40S ribosomal protein S9 RPS9 Homo sapiens 50.85 17.53 4 19 P26599 Polypyrimidine tract-binding protein 1 PTBP1 Homo sapiens 75.12 15.63 4 18 P31939 Bifunctional purine biosynthesis protein PURH ATIC Homo sapiens 68.66 8.78 4 18 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase] P49755 Transmembrane amp24 domain-containing TMED10 Homo sapiens 68.15 12.79 2 18 protein 10 P49411 Elongation factor Tu, mitochondrial TUFM Homo sapiens 66.68 18.58 5 18 P14550 Alcohol dehydrogenase [NADP(+)] AKR1A1 Homo sapiens 63.84 13.54 4 18 Q14195 Dihydropyrimidinase-related protein 3 DPYSL3 Homo sapiens 62.54 21.58 8 18 Q15436 Protein transport protein Sec23A SEC23A Homo sapiens 60.90 5.75 3 18 Q9Y2Q3 Glutathione S-transferase kappa 1 GSTK1 Homo sapiens 59.42 23.89 4 18 Q14108 Lysosome membrane protein 2 SCARB2 Homo sapiens 58.13 9.00 3 18 P48444 Coatomer subunit delta ARCN1 Homo sapiens 56.94 6.46 3 18 P41250 Glycine-tRNA ligase GARS Homo sapiens 55.95 7.71 4 18 Q04760 Lactoylglutathione lyase GLO1 Homo sapiens 54.07 19.57 3 18 P50914 60S ribosomal protein L14 RPL14 Homo sapiens 53.56 15.35 3 18 P35232 Prohibitin PHB Homo sapiens 53.10 12.13 3 18 P11940 Polyadenylate-binding protein 1 PABPC1 Homo sapiens 49.49 7.55 4 18 Q9H4M9 EH domain-containing protein 1 EHD1 Homo sapiens 79.67 12.36 4 17 Q15185 Prostaglandin E synthase 3 PTGES3 Homo sapiens 73.37 24.38 3 17 Q13492 Phosphatidylinositol-binding clathrin assembly PICALM Homo sapiens 61.52 4.91 2 17 protein P60953 Cell division control protein 42 homolog CDC42 Homo sapiens 61.37 20.42 3 17 P54920 Alpha-soluble NSF attachment protein NAPA Homo sapiens 58.25 17.97 4 17 O00571 ATP-dependent RNA helicase DDX3X DDX3X Homo sapiens 55.60 9.67 5 17 Q13162 Peroxiredoxin-4 PRDX4 Homo sapiens 48.19 11.81 3 17 P61160 Actin-related protein 2 ACTR2 Homo sapiens 44.56 17.77 6 17 P30048 Thioredoxin-dependent peroxide reductase, PRDX3 Homo sapiens 79.84 18.75 2 16 mitochondrial P62280 40S ribosomal protein S11 RPS11 Homo sapiens 67.34 16.46 2 16 Q8IUX7 Adipocyte enhancer-binding protein 1 AEBP1 Homo sapiens 65.82 5.96 4 16 P55084 Trifunctional enzyme subunit beta, HADHB Homo sapiens 63.53 9.28 3 16 mitochondrial Q07960 Rho GTPase-activating protein 1 ARHGAP1 Homo sapiens 62.30 14.81 4 16 P98160 Basement membrane-specific heparan sulfate HSPG2 Homo sapiens 61.92 1.80 5 16 proteoglycan core protein P54709 Sodium/potassium-transporting ATPase ATP1B3 Homo sapiens 58.07 17.20 3 16 subunit beta-3 P37837 Transaldolase TALDO1 Homo sapiens 53.35 7.12 2 16 P61224 Ras-related protein Rap-1b RAP1B Homo sapiens 49.98 20.65 3 16 Q14103 Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Homo sapiens 48.34 6.76 2 16 P14866 Heterogeneous nuclear ribonucleoprotein L HNRNPL Homo sapiens 71.48 8.66 2 15 P51636 Caveolin-2 CAV2 Homo sapiens 65.54 29.63 3 15 O15511 Actin-related protein 2/3 complex subunit 5 ARPC5 Homo sapiens 61.90 20.53 2 15 O43242 26S proteasome non-ATPase regulatory PSMD3 Homo sapiens 61.84 5.62 2 15 subunit 3 Q08211 ATP-dependent RNA helicase A DHX9 Homo sapiens 61.31 5.04 4 15 Q15181 Inorganic pyrophosphatase PPA1 Homo sapiens 60.87 23.18 4 15 P46777 60S ribosomal protein L5 RPL5 Homo sapiens 60.47 19.87 4 15 P61604 10 kDa heat shock protein, mitochondrial HSPE1 Homo sapiens 58.06 33.33 3 15 P10620 Microsomal glutathione S-transferase 1 MGST1 Homo sapiens 57.64 19.35 2 15 Q13765 Nascent polypeptide-associated complex NACA Homo sapiens 56.71 18.60 3 15 subunit alpha P17858 6-phosphofructokinase, liver type PFKL Homo sapiens 55.45 6.54 3 15 Q9P2E9 Ribosome-binding protein 1 RRBP1 Homo sapiens 52.97 6.60 6 15 P16615 Sarcoplasmic/endoplasmic reticulum calcium ATP2A2 Homo sapiens 52.48 5.37 4 15 ATPase 2 P15121 Aldose reductase AKR1B1 Homo sapiens 51.96 24.37 4 15 Q8NC51 Plasminogen activator inhibitor 1 RNA-binding SERBP1 Homo sapiens 49.13 18.14 5 15 protein P51659 Peroxisomal multifuctional enzyme type 2 HSD17B4 Homo sapiens 48.08 11.01 5 15 P10155 60 kDa SS-A/Ro ribonucleoprotein TROVE2 Homo sapiens 48.07 4.46 2 15 O94979 Protein transport protein Sec31A SEC31A Homo sapiens 47.81 4.51 4 15 P46778 60S ribosomal protein L21 RPL21 Homo sapiens 46.39 27.50 3 15 P78539 Sushi repeat-containing protein SRPX SRPX Homo sapiens 45.56 7.76 3 15 P51148 Ras-related protein Rab-5C RAB5C Homo sapiens 44.79 23.15 4 15 Q14847 LIM and SH3 domain protein 1 LASP1 Homo sapiens 44.78 14.18 3 15 Q9ULV4 Coronin-1C CORO1C Homo sapiens 44.37 8.23 3 15 O43776 Asparagine--tRNA ligase, cytoplasmic NARS Homo sapiens 43.41 8.94 4 15 Q14152 Eukaryotic translation initiation factor 3 subunit A EIF3A Homo sapiens 42.47 3.47 4 15 P35268 60S ribosomal protein L22 RPL22 Homo sapiens 41.79 18.75 2 15 P37235 Hippocalcin-like protein 1 HPCAL1 Homo sapiens 41.04 23.83 4 15 P00441 Superoxide dismutase [CuZn] SOD1 Homo sapiens 75.69 32.47 4 14 Q99460 26S proteasome non-ATPase regulatory PSMD1 Homo sapiens 69.67 5.46 3 14 subunit 1 Q08431 Lactadherin MFGE8 Homo sapiens 67.71 8.53 2 14 O95373 Importin-7 IPO7 Homo sapiens 61.22 4.53 3 14 Q16181 Septin-7 41889 Homo sapiens 55.03 13.50 4 14 Q13200 26S proteasome non-ATPase regulatory PSMD2 Homo sapiens 53.05 5.18 3 14 subunit 2 Q9Y265 RuvB-like 1 RUVBL1 Homo sapiens 50.48 15.79 5 14 Q9UBG0 C-type mannose receptor 2 MRC2 Homo sapiens 48.78 2.77 3 14 P51571 Translocon-associated protein subunit delta SSR4 Homo sapiens 44.44 24.86 3 14 Q9H8H3 Methyltransferase-like protein 7A METTL7A Homo sapiens 42.92 12.30 2 14 Q16698 2,4-dienoyl-CoA reductase, mitochondrial DECR1 Homo sapiens 40.03 13.73 3 14 Q9UHD8 Septin-9 41891 Homo sapiens 39.86 11.60 5 14 Q9NVA2 Septin-11 41893 Homo sapiens 38.96 11.19 4 14 Q99829 Copine-1 CPNE1 Homo sapiens 38.95 6.33 3 14 Q92499 ATP-dependent RNA helicase DDX1 DDX1 Homo sapiens 64.96 7.43 3 13 P07099 Epoxide hydrolase 1 EPHX1 Homo sapiens 62.32 10.77 3 13 Q99497 Protein DJ-1 PARK7 Homo sapiens 58.25 29.63 3 13 P40227 T-complex protein 1 subunit zeta CCT6A Homo sapiens 57.05 6.97 2 13 P28838 Cytosol aminopeptidase LAP3 Homo sapiens 51.95 12.33 4 13 Q9UBI6 Guanine nucleotide-binding protein GNG12 Homo sapiens 50.08 31.94 2 13 G(I)/G(S)/G(O) subunit gamma-12 O14818 Proteasome subunit alpha type-7 PSMA7 Homo sapiens 48.17 20.56 3 13 P19367 Hexokinase-1 HK1 Homo sapiens 45.34 5.89 4 13 P39023 60S ribosomal protein L3 RPL3 Homo sapiens 44.04 12.66 3 13 Q6YHK3 CD109 antigen CD109 Homo sapiens 42.37 7.47 7 13 P46776 60S ribosomal protein L27a RPL27A Homo sapiens 39.08 14.19 2 13 Q99584 Protein S100-A13 S100A13 Homo sapiens 39.08 23.47 2 13 Q15836 Vesicle-associated membrane protein 3 VAMP3 Homo sapiens 38.92 33.00 2 13 Q92688 Acidic leucine-rich nuclear phosphoprotein 32 ANP32B Homo sapiens 38.66 15.94 3 13 family member B Q9Y6N5 Sulfide:quinone oxidoreductase, mitochondrial SQRDL Homo sapiens 37.33 10.00 4 13 P62318 Small nuclear ribonucleoprotein Sm D3 SNRPD3 Homo sapiens 34.78 15.08 2 13 P01008 Antithrombin-III SERPINC1 Homo sapiens 45.87 4.31 2 12 P28066 Proteasome subunit alpha type-5 PSMA5 Homo sapiens 43.47 22.41 3 12 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 Homo sapiens 41.65 10.14 3 12 P48047 ATP synthase subunit O, mitochondrial ATP5O Homo sapiens 40.13 29.11 4 12 Q9BWM7 Sideroflexin-3 SFXN3 Homo sapiens 37.95 8.62 2 12 P61088 Ubiquitin-conjugating enzyme E2 N UBE2N Homo sapiens 36.77 27.63 3 12 Q05682 Caldesmon CALD1 Homo sapiens 36.05 5.30 4 12 P38159 RNA-binding motif protein, X chromosome RBMX Homo sapiens 35.98 8.95 3 12 O15260 Surfeit locus protein 4 SURF4 Homo sapiens 35.84 8.55 2 12 P30493 HLA class I histocompatibility antigen, B-55 HLA-B Homo sapiens 34.77 14.64 4 12 alpha chain P62851 40S ribosomal protein S25 RPS25 Homo sapiens 34.69 16.00 3 12 P27816 Microtubule-associated protein 4 MAP4 Homo sapiens 34.36 4.69 4 12 P61353 60S ribosomal protein L27 RPL27 Homo sapiens 33.55 27.94 3 12 P52272 Heterogeneous nuclear ribonucleoprotein M HNRNPM Homo sapiens 33.53 7.67 4 12 Q15417 Calponin-3 CNN3 Homo sapiens 33.42 10.64 3 12 P49773 Histidine triad nucleotide-binding protein 1 HINT1 Homo sapiens 69.01 34.92 2 11 Q15121 Astrocytic phosphoprotein PEA-15 PEA15 Homo sapiens 52.21 27.69 3 11 Q12905 Interleukin enhancer-binding factor 2 ILF2 Homo sapiens 43.95 8.72 2 11 P68402 Platelet-activating factor acetylhydrolase IB PAFAH1B2 Homo sapiens 43.27 12.23 2 11 subunit beta P08253 72 kDa type IV collagenase MMP2 Homo sapiens 42.46 10.91 4 11 P62333 26S protease regulatory subunit 10B PSMC6 Homo sapiens 41.19 14.91 4 11 P36957 Dihydrolipoyllysine-residue DLST Homo sapiens 40.04 10.15 3 11 succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial P61313 60S ribosomal protein L15 RPL15 Homo sapiens 38.61 12.75 2 11 P04632 Calpain small subunit 1 CAPNS1 Homo sapiens 36.46 16.42 3 11 P11047 Laminin subunit gamma-1 LAMC1 Homo sapiens 36.41 1.74 2 11 P08195 4F2 cell-surface antigen heavy chain SLC3A2 Homo sapiens 34.57 4.13 2 11 Q01105 Protein SET SET Homo sapiens 34.28 12.07 3 11 Q9Y277 Voltage-dependent anion-selective channel VDAC3 Homo sapiens 34.15 19.08 4 11 protein 3 P62753 40S ribosomal protein S6 RPS6 Homo sapiens 31.26 10.84 2 11 O14979 Heterogeneous nuclear ribonucleoprotein D- HNRNPDL Homo sapiens 31.19 9.76 3 11 like P30040 Endoplasmic reticulum resident protein 29 ERP29 Homo sapiens 29.37 8.43 2 11 O00410 Importin-5 IPO5 Homo sapiens 46.49 6.47 4 10 Q8IWE2 Protein NOXP20 FAM114A1 Homo sapiens 45.84 5.68 2 10 O14579 Coatomer subunit epsilon COPE Homo sapiens 44.19 6.82 2 10 O00154 Cytosolic acyl coenzyme A thioester hydrolase ACOT7 Homo sapiens 41.44 12.37 3 10 Q9Y3F4 Serine-threonine kinase receptor-associated STRAP Homo sapiens 41.18 8.86 2 10 protein P09429 High mobility group protein B1 HMGB1 Homo sapiens 39.56 27.44 4 10 O15144 Actin-related protein 2/3 complex subunit 2 ARPC2 Homo sapiens 36.55 18.00 3 10 Q96CW1 AP-2 complex subunit mu AP2M1 Homo sapiens 32.81 12.87 4 10 P84103 Serine/arginine-rich splicing factor 3 SRSF3 Homo sapiens 31.49 14.02 2 10 O60763 General vesicular transport factor p115 USO1 Homo sapiens 31.07 5.41 4 10 P40429 60S ribosomal protein L13a RPL13A Homo sapiens 25.35 8.87 2 10 Q6DD88 Atlastin-3 ATL3 Homo sapiens 40.84 12.38 4 9 P09622 Dihydrolipoyl dehydrogenase, mitochondrial DLD Homo sapiens 40.56 6.48 2 9 Q9BWD1 Acetyl-CoA acetyltransferase, cytosolic ACAT2 Homo sapiens 37.63 14.61 3 9 Q00341 Vigilin HDLBP Homo sapiens 37.29 4.10 3 9 Q99798 Aconitate hydratase, mitochondrial ACO2 Homo sapiens 36.61 4.49 2 9 Q02878 60S ribosomal proteins L6 RPL6 Homo sapiens 34.78 15.63 3 9 Q15008 26S proteasome non-ATPase regulatory PSMD6 Homo sapiens 34.04 7.20 2 9 subunit 6 P21266 Glutathione S-transferase Mu 3 GSTM3 Homo sapiens 31.19 17.33 3 9 P10301 Ras-related protein R-Ras RRAS Homo sapiens 29.36 12.84 2 9 Q06323 Proteasome activator complex subunit 1 PSME1 Homo sapiens 26.97 23.29 4 9 Q13557 Calcium/calmodulin-dependent protein kinase CAMK2D Homo sapiens 23.13 8.62 3 9 type II subunit delta P21964 Catechol O-methyltransferase COMT Homo sapiens 34.16 8.49 2 8 P63167 Dynein light chain 1, cytoplasmic DYNLL1 Homo sapiens 33.21 37.08 2 8 Q02952 A-kinase anchor protein 12 AKAP12 Homo sapiens 32.58 3.42 3 8 P16278 Beta-galactosidase GLB1 Homo sapiens 29.46 3.69 2 8 P62081 40S ribosomal protein S7 RPS7 Homo sapiens 27.65 17.53 2 8 P31937 3-hydroxyisobutyrate dehydrogenase, HIBADH Homo sapiens 27.07 7.14 2 8 mitochondrial Q96QK1 Vacuolar protein sorting-associated protein 35 VPS35 Homo sapiens 26.95 2.89 2 8 P33176 Kinesin-1 heavy chain KIF5B Homo sapiens 26.86 2.80 2 8 P61019 Ras-related protein Rab-2A RAB2A Homo sapiens 26.44 18.87 3 8 O00231 26S proteasome non-ATPase regulatory PSMD11 Homo sapiens 25.87 8.77 3 8 subunit 11 P26373 60S ribosomal protein L13 RPL13 Homo sapiens 25.81 10.90 2 8 Q13724 Mannosyl-oligosaccharide glucosidase MOGS Homo sapiens 25.51 3.58 2 8 O95816 BAG family molecular chaperone regulator 2 BAG2 Homo sapiens 24.67 13.27 2 8 P06703 Protein S100-A6 S100A6 Homo sapiens 24.35 37.78 2 8 P34897 Serine hydroxymethyltransferase, SHMT2 Homo sapiens 24.35 10.32 4 8 mitochondrial P17844 Probable ATP-dependent RNA helicase DDX5 DDX5 Homo sapiens 24.22 5.86 3 8 O94905 Erlin-2 ERLIN2 Homo sapiens 23.59 6.49 2 8 P08648 Integrin alpha-5 ITGA5 Homo sapiens 23.55 5.62 4 8 P62917 60S ribosomal protein L8 RPL8 Homo sapiens 22.51 10.51 2 8 P01023 Alpha-2-macroglobulin A2M Homo sapiens 20.91 2.04 3 8 P26022 Pentraxin-related protein PTX3 PTX3 Homo sapiens 20.28 13.12 4 8 P07814 Bifunctional glutamate/proline--tRNA ligase EPRS Homo sapiens 34.10 2.18 2 7 Q6IBS0 Twinfilin-2 TWF2 Homo sapiens 29.62 9.74 2 7 P49257 Protein ERGIC-53 LMAN1 Homo sapiens 28.55 10.39 2 7 O75368 SH3 domain-binding glutamic acid-rich-like SH3BGRL Homo sapiens 26.17 26.32 2 7 protein Q07666 KH domain-contaning, RNA-binding, signal KHDRBS1 Homo sapiens 24.96 7.67 2 7 transduction-associated protein 1 P46977 Dolichyl-diphosphooligosaccharide--protein STT3A Homo sapiens 24.54 3.69 2 7 glycosyltransferase subunit STT3A Q7L2H7 Eukaryotic translation initiation factor 3 subunit M EIF3M Homo sapiens 24.21 6.95 2 7 Q15847 Adipogenesis regulatory factor ADIRF Homo sapiens 23.65 59.21 2 7 P48643 T-complex protein 1 subunit epsilon CCT5 Homo sapiens 23.35 11.83 4 7 P12268 Inosine-5-monophosphate dehydrogenase 2 IMPDH2 Homo sapiens 23.35 9.73 3 7 Q63ZY3 KN motif and ankyrin repeat domain- KANK2 Homo sapiens 23.26 4.70 3 7 containing protein 2 P22102 Trifunctional purine biosynthetic protein GART Homo sapiens 22.93 2.67 2 7 adenosine-3 [Includes: Phosphoribosylamine-- glycine ligase] P49458 Signal recognition particle 9 kDa protein SRP9 Homo sapiens 22.86 23.26 2 7 P05023 Sodium/potassium-transporting ATPase ATP1A1 Homo sapiens 22.17 3.91 3 7 subunit alpha-1 P02792 Ferritin light chain FTL Homo sapiens 22.12 26.86 3 7 P35613 Basigin BSG Homo sapiens 21.87 8.31 2 7 P18621 60S ribosomal protein L17 RPL17 Homo sapiens 21.02 17.93 3 7 P11177 Pyruvate dehydrogenase E1 component PDHB Homo sapiens 19.98 8.91 2 7 subunit beta, mitochondrial P62330 ADP-ribosylation factor 6 ARF6 Homo sapiens 19.84 12.57 2 7 Q99832 T-complex protein 1 subunit eta CCT7 Homo sapiens 19.63 7.92 3 7 P35637 RNA-binding protein FUS FUS Homo sapiens 19.53 6.27 2 7 P42677 40S ribosomal protein S27 RPS27 Homo sapiens 19.53 25.00 2 7 P31948 Stress-induced-phosphoprotein 1 STIP1 Homo sapiens 19.50 7.73 3 7 P26640 Valine--tRNA ligase VARS Homo sapiens 18.39 1.98 2 7 P15586 N-acetylglucosamine-6-sulfatase GNS Homo sapiens 18.07 4.71 2 7 P62191 26S protease regulatory subunit 4 PSMC1 Homo sapiens 30.43 8.18 2 6 Q13423 NAD(P) transhydrogenase, mitochondrial NNT Homo sapiens 28.78 3.41 2 6 P09960 Leukotriene A-4 hydrolase LTA4H Homo sapiens 26.18 5.07 2 6 P22695 Cytochrome b-c1 complex subunit 2, UQCRC22 Homo sapiens 24.46 10.82 3 6 mitochondrial P10619 Lysosomal protective protein CTSA Homo sapiens 22.01 5.00 2 6 P23381 Tryptophan--tRNA ligase, cytoplasmic WARS Homo sapiens 21.16 5.73 2 6 P02794 Ferritin heavy chain FTH1 Homo sapiens 20.44 33.33 3 6 P55010 Eukaryotic translation initiation factor 5 EIF5 Homo sapiens 18.71 9.98 3 6 P35555 Fibrillin-1 FBN1 Homo sapiens 18.54 2.16 4 6 P39656 Dolichyl-diphosphooligosaccharide-protein DDOST Homo sapiens 18.03 7.89 3 6 glycosyltransferase 48 kDa subunit Q13425 Beta-2-syntrophin SNTB2 Homo sapiens 17.22 3.89 2 6 Q99961 Endophilin-A2 SH3GL1 Homo sapiens 17.15 8.97 2 6 P54136 Arginine--tRNA ligase, cytoplasmic RARS Homo sapiens 17.09 3.64 2 6 P20073 Annexin A7 ANXA7 Homo sapiens 15.98 8.20 3 6 Q15113 Procollagen C-endopeptidase enhancer 1 PCOLCE Homo sapiens 15.72 6.01 2 6 P30085 UMP-CMP kinase CMPK1 Homo sapiens 24.26 16.84 2 5 Q16881 Thioredoxin reductase 1, cytoplasmic TXNRD1 Homo sapiens 22.69 5.86 2 5 P00568 Adenylate kinase isoenzyme 1 AK1 Homo sapiens 19.57 19.07 2 5 P43243 Matrin-3 MATR3 Homo sapiens 18.67 6.02 3 5 O95292 Vesicle-associated membrane protein- VAPB Homo sapiens 16.59 10.70 2 5 associated protein B/C O43237 Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Homo sapiens 16.24 5.08 2 5 P23526 Adenosylhomocysteinase AHCY Homo sapiens 15.78 10.65 3 5 P13804 Electron transfer flavoprotein subunit alpha, ETFA Homo sapiens 15.40 8.71 2 5 mitochondrial P13010 X-ray repair cross-complementing protein 5 XRCC5 Homo sapiens 15.04 6.42 3 5 Q01995 Transgelin TAGLN Homo sapiens 15.00 12.44 2 5 P60900 Proteasome subunit alpha type-6 PSMA6 Homo sapiens 14.55 10.16 2 5 P07996 Thrombospondin-1 THBS1 Homo sapiens 14.55 1.97 2 5 Q9UEY8 Gamma-adducin ADD3 Homo sapiens 14.49 3.54 2 5 O60488 Long-chain-fatty-acid--CoA ligase 4 ACSL4 Homo sapiens 13.17 4.36 2 5 Q15942 Zyxin ZYX Homo sapiens 22.91 6.64 2 4 O14980 Exportin-1 XPO1 Homo sapiens 22.59 4.20 2 4 O75131 Copine-3 CPNE3 Homo sapiens 18.51 6.33 2 4 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Homo sapiens 17.39 16.48 2 4 O94855 Protein transport protein Sec24D SEC24D Homo sapiens 16.72 2.91 2 4 P21291 Cysteine and glycine-rich protein 1 CSRP1 Homo sapiens 16.40 19.17 2 4 Q9BVK6 Transmembrane emp24 domain-containing TMED9 Homo sapiens 15.78 14.47 2 4 protein 9 Q13283 Res GTPase-activating protein-binding protein 1 G3BP1 Homo sapiens 15.21 6.01 2 4 Q9NYL9 Tropomodulin-3 TMOD3 Homo sapiens 14.89 9.38 2 4 P62195 26S protease regulatory subunit 8 PSMC5 Homo sapiens 14.87 12.07 3 4 P55884 Eukaryolic translation initiation factor 3 subunit B EIF3B Homo sapiens 14.81 4.67 2 4 P33527 Multidrug resistance-associated protein 1 ABCC1 Homo sapiens 13.99 2.02 2 4 O15143 Actin-related protein 2/3 complex subunit 1B ARPC1B Homo sapiens 13.50 11.83 3 4 Q9Y262 Eukaryotic translation initiation factor 3 subunit L EIF3L Homo sapiens 13.47 3.55 2 4 Q02809 Procollagen-lysine, 2-oxoglutarate 5- PLOD1 Homo sapiens 13.29 3.71 2 4 dioxygenase 1 P23246 Splicing factor, proline- and glutamine-rich SFPQ Homo sapiens 13.13 6.22 3 4 P30046 D-dopachrome decarboxylase DDT Homo sapiens 12.61 19.49 2 4 Q9NQW7 Xaa-Pro aminopeptidase 1 XPNPEP1 Homo sapiens 12.18 4.82 2 4 Q9NR31 GTP-binding protein SAR1a SAR1A Homo sapiens 12.08 15.66 2 4 Q03252 Lamin-B2 LMNB2 Homo sapiens 11.81 5.67 3 4 P78344 Eukaryotic translation initiation factor 4 EIF4G2 Homo sapiens 11.24 2.32 2 4 gamma 2 P41252 Isoleucine-tRNA ligase, cytoplasmic IARS Homo sapiens 11.24 2.69 3 4 Q7L576 Cytoplasmic FMR1-interacting protein 1 CYFIP1 Homo sapiens 11.23 1.84 2 4 P67809 Nuclease-sensitive element-binding protein 1 YBX1 Homo sapiens 10.94 11.11 2 4 P35611 Alpha-adducin ADD1 Homo sapiens 10.23 4.21 2 4 Q9BR76 Coronin-1B CORO1B Homo sapiens 10.19 3.48 2 4 P27695 DNA-(apurinic or apyrimidinic site) lyase APEX1 Homo sapiens 16.69 11.01 2 3 O15460 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 Homo sapiens 14.16 6.17 2 3 Q96HE7 ERO1-like protein alpha ERO1L Homo sapiens 13.09 7.26 2 3 P61769 Beta-2-microglobulin [Cleaved into: Beta-2- BaM Homo sapiens 11.85 26.89 2 3 microglobulin form pl 5.3] PI4854 Cytochrome c oxidase subunit 6B1 COX6B1 Homo sapiens 11.35 33.72 2 3 P00390 Glutathione reductase, mitochondrial GSR Homo sapiens 11.32 6.32 2 3 P13798 Acylamino-acid-releasing enzyme APEH Homo sapiens 10.86 4.78 2 3 Q08257 Quinone oxidoreductase CRYZ Homo sapiens 9.95 10.64 2 3 Q9NTK5 Obg-like ATPase 1 OLA1 Homo sapiens 9.88 7.32 2 3 Q13418 Integrin-linked protein kinase ILK Homo sapiens 9.86 8.63 3 3 P61009 Signal peptidase complex subunit 3 SPCS3 Homo sapiens 9.85 12.78 2 3 Q969H8 UPF0556 protein C19orf10 C19ORF10 Homo sapiens 9.71 15.03 2 3 P05455 Lupus La protein SSB Homo sapiens 9.57 6.37 2 3 P51858 Hepatoma-derived growth factor HDGF Homo sapiens 9.38 13.75 2 3 O00425 Insulin-like growth factor 2 mRNA-binding IGF2BP3 Homo sapiens 8.88 5.18 2 3 protein 3 P20042 Eukaryotic translation initiation factor 2 subunit 2 EIF2S2 Homo sapiens 8.84 8.11 2 3 P62495 Eukaryotic peptide chain release factor ETF1 Homo sapiens 8.74 6.41 2 3 subunit 1 P11279 Lysosome-associated membrane glycoprotein 1 LAMP1 Homo sapiens 8.45 6.00 2 3 Q9NUQ9 Protein FAM49B FAM49B Homo sapiens 8.18 8.64 2 3 Q14247 Src substrate cortactin CTTN Homo sapiens 8.15 3.64 2 3 P27708 CAD protein [Includes: Glutamine-dependent CAD Homo sapiens 7.94 0.94 2 3 carbamoyl-phosphate synthase] Q9NSE4 isoleucine-tRNA ligase, mitochondrial IARS2 Homo sapiens 7.76 2.08 2 3 Q9H4A4 Aminopeptidase B RNPEP Homo sapiens 7.62 3.54 2 3 P62913 60S ribosomal protein L11 RPL11 Homo sapiens 7.39 12.92 2 3 P39060 Collagen alpha-1(XVIII) chain [Cleaved into: COL18A1 Homo sapiens 11.40 2.85 2 2 Endostatin] P26368 Splicing factor U2AF 65 kDa subunit U2AF2 Homo sapiens 8.61 6.11 2 2 Q687X5 Metalloreductase STEAP4 STEAP4 Homo sapiens 7.68 7.19 2 2 P31153 S-adenosylmethionine synthase isoform type-2 MAT2A Homo sapiens 7.36 9.11 2 2 Q9Y240 C-type lectin domain family 11 member A CLEC11A Homo sapiens 6.98 8.98 2 2 P50213 Isocitrate dehydrogenase [NAD] subunit IDH3A Homo sapiens 6.43 10.38 2 2 alpha, mitochondrial Q09028 Histone-binding protein RBBP4 RBBP4 Homo sapiens 6.37 4.94 2 2 P32969 60S ribosomal protein L9 RPL9 Homo sapiens 6.36 11.46 2 2 P21399 Cytoplasmic aconitate hydratase ACO1 Homo sapiens 6.23 3.15 2 2 P00492 Hypoxanthine-guanine HPRT1 Homo sapiens 6.12 10.55 2 2 phosphoribosytransferase P49591 Serine--tRNA ligase, cytoplasmic SARS Homo sapiens 5.72 5.45 2 2 P30520 Adenylosuccinate synthetase isozyme 2 ADSS Homo sapiens 5.55 4.61 2 2 P22234 Multifunctional protein ADE2 [Includes: PAICS Homo sapiens 5.35 6.12 2 2 Phosphoribosylaminoimidazole- succinocarboxamide synthase] P11586 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Homo sapiens 5.21 2.78 2 2 Q92616 Translational activator GCN1 GCN1L1 Homo sapiens 5.02 1.05 2 2 VFE on scaffold P02454 Collagen alpha-1(I) chain COL1A1 Rattus norvegicus 19462.74 69.79 79 24841 P02452 Collegen alpha-1(I) chain COL1A1 Homo sapiens 9931.72 59.97 58 13046 P02466 Collagen alpha-2(I) chain COL1A2 Rattus norvegicus 12949.24 67.49 67 11720 P08123 Collagen alpha-2(I) chain COL1A2 Homo sapiens 3724.87 54.32 41 3438 Q09666 Neuroblast differentiation-associated protein AHNAK Homo sapiens 3402.71 42.18 112 1007 AHNAK P12111 Collagen alpha-3(VI) chain COL6A3 Homo sapiens 3044.09 31.82 76 895 P02461 Collagen alpha-1(III) chain COL3A1 Homo sapiens 661.63 21.01 17 826 P02751 Fibronectin FN1 Homo sapiens 2864.69 38.56 65 739 P12109 Collegen alpha-1(VI) chain COL6A1 Homo sapiens 1371.07 28.02 21 680 P08670 Vimeritin VIM Homo sapiens 2057.68 54.72 32 597 P21333 Filamin-A FLNA Homo sapiens 1970.03 38.23 62 483 Q15149 Plectin PLEC Homo sapiens 1624.20 24.68 81 445 P35579 Myosin-9 MYH9 Homo sapiens 1870.54 35.56 53 433 P60711 Actin cytoplasmic 1 ACTB Rattus norvegicus 1567.81 61.87 16 410 P02545 Prelamin-A/C [Cleaved into: Lamin-A/C] LMNA Homo sapiens 1315.37 53.16 33 387 P14618 Pyruvate kinase PKM PKM Homo sapiens 1486.10 61.21 28 383 P02458 Collagen alpha-1(II) chain COL2A1 Homo sapiens 529.20 5.85 4 344 P07355 Annexin A2 ANXA2 Homo sapiens 1284.07 56.11 20 331 P11021 78 kDa glucose-regulated protein HSPA5 Homo sapiens 1128.68 38.53 21 310 Q00610 Clathrin heavy chain 1 CLTC Homo sapiens 1224.44 29.91 38 306 P04406 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Homo sapiens 1064.45 53.13 13 306 P07437 Tubulin beta chain TUBB Homo sapiens 1124.26 66.89 21 304 P12814 Alpha-actinin-1 ACTN1 Homo sapiens 1094.44 47.76 33 293 P68371 Tubulin beta-4B chain TUBB4B Homo sapiens 1083.09 70.56 22 288 P15144 Aminopeptidase N ANPEP Homo sapiens 990.71 27.82 25 278 P13941 Collagen alpha-1(III) chain COL3A1 Rattus norvegicus 294.49 10.59 9 278 P11142 Heat shock cognate 71 kDa protein HSPAB Homo sapiens 996.23 41.33 22 263 Q13885 Tubulin beta-2A chain TUBB2A Homo sapiens 876.91 61.12 19 245 P12110 Collagen alpha-2(VI) chain COL6A2 Homo sapiens 667.72 31.80 23 244 P00558 Phosphoglycerate kinase 1 PGK1 Homo sapiens 936.31 52.04 17 234 P08238 Heat shock protein HSP 90-beta HSP90AB1 Homo sapiens 839.05 33.84 20 229 O43707 Alpha-actinin-4 ACTN4 Homo sapiens 855.61 49.62 32 228 P68363 Tubulin alpha-1B chain TUBA1B Homo sapiens 785.85 48.78 15 222 Q13509 Tubulin beta-3 chain TUBB3 Homo sapiens 741.48 42.44 15 220 P06758 Annexin A5 ANXA5 Homo sapiens 758.36 67.50 18 219 P68035 Actin alpha cardiac muscle 1 ACTC1 Rattus norvegicus 720.51 43.77 12 217 P05539 Collagen alpha-1(II) chain COL2A1 Rattus norvegicus 361.49 5.00 3 212 P66576 ATP synthase subunit beta; mitochondrial ATP5B Homo sapiens 754.28 42.72 16 209 P68104 Elongation factor 1-alpha 1 EEF1A1 Homo sapiens 842.24 34.20 11 203 P07900 Heat shock protein HSP 90-alpha HSP90AA1 Homo sapiens 727.70 29.51 19 201 P04083 Annexin A1 ANXA1 Homo sapiens 807.88 52.60 16 199 Q9Y490 Talin-1 TLN1 Homo sapiens 832.01 20.90 30 198 P14625 Endoplasmin HSP90B1 Homo sapiens 722.04 32.88 21 197 P08133 Annexin A6 ANXA6 Homo sapiens 685.55 45.17 22 186 P50454 Serpin H1 SERPINH1 Homo sapiens 779.11 50.00 15 185 P04075 Fructose-bisphosphate aldolase A ALDOA Homo sapiens 742.79 65.66 17 175 P06733 Alpha-enolase ENO1 Homo sapiens 607.87 54.15 16 168 Q04828 Aldo-keta reductase family 1 member C1 AKR1C1 Homo sapiens 671.12 49.85 12 165 P29401 Transketolase TKT Homo sapiens 690.60 39.33 17 157 P07237 Protein disulfide-isomerase P4HB Homo sapiens 602.33 48.62 21 157 P60174 Triosephosphate isomerase TPI1 Homo sapiens 601.01 66.08 14 155 P18206 Vinculin VCL Homo sapiens 521.43 35.36 28 154 P06396 Gelsolin GSN Homo sapiens 657.52 23.66 14 152 Q16555 Dihydropyrimidinase-related protein 2 DPYSL2 Homo sapiens 619.56 48.95 17 152 P07585 Decorin DCN Homo sapiens 513.00 45.96 14 151 Q14764 Major vault protein MVP Homo sapiens 515.55 34.04 20 147 P46940 Ras GTPase-activating-like protein IQGAP1 IQGAP1 Homo sapiens 567.55 20.16 21 142 P13639 Elongation factor 2 EEF2 Homo sapiens 460.85 31.12 23 142 P30101 Protein disulfide-isomerase A3 PDIA3 Homo sapiens 482.71 42.97 16 137 Q9BUF5 Tubulin beta-6 chain TUBB6 Homo sapiens 454.39 58.07 18 137 P07602 Proactivator polypeptide [Cleaved into: PSAP Homo sapiens 264.99 26.91 13 137 Saposin-A] P62937 Peptidyl-prolyl cis-trans isomerase A PPIA Homo sapiens 494.59 55.76 9 136 P62805 Histone H4 HIST1H4A Homo sapiens 449.47 51.46 6 131 P55072 Transitional endoplasmic reticulum ATPase VCP Homo sapiens 519.55 43.18 23 129 P11413 Glucose-6-phosphate 1-dehydrogenese G6PD Homo sapiens 488.37 40.78 15 129 P18669 Phosphoglycerate mutase 1 PGAM1 Homo sapiens 467.11 44.88 9 129 O43852 Calumenin CALU Homo sapiens 526.31 52.38 14 127 P16152 Carbonyl reductase [NADPH] 1 CBR1 Homo sapiens 493.61 58.12 11 123 Q9NZN4 EH domain-containing protein 2 EHD2 Homo sapiens 471.67 49.91 18 122 P13489 Ribonuclease inhibitor RNH1 Homo sapiens 471.22 44.47 13 121 P35555 Fibrillin-1 FBN1 Homo sapiens 395.19 13.79 25 114 P49327 Fatty acid synthese FASN Homo sapiens 444.87 15.13 23 112 P62260 14-3-3 protein epsilon YWHAE Rattus norvegicus 333.75 40.00 8 112 P00338 L-lactate dehydrogenase A chain LDHA Homo sapiens 389.25 39.16 11 111 Q99536 Synaptic vesicle membrane protein VAT-1 VAT1 Homo sapiens 418.13 35.37 8 110 homolog Q06830 Peroxiredoxin-1 PRDX1 Homo sapiens 432.15 56.78 10 109 P98095 Fibulin-2 FBLN2 Homo sapiens 415.65 19.85 15 109 O60814 Histone H2B type 1-K HIST1H2BK Homo sapiens 305.88 34.92 4 109 O14315 Filamin-C FLNC Homo sapiens 459.99 11.08 17 107 Q07065 Cytoskeleton-associated protein 4 CKAP4 Homo sapiens 394.33 38.37 18 105 P27348 14-3-3 protein theta YWHAQ Homo sapiens 347.51 38.37 7 104 P63104 14-3-3 protein zeta/delta YWHAZ Homo sapiens 339.16 42.86 8 103 Q9NZM1 Myoferlin MYOF Homo sapiens 387.07 13.93 19 101 P10899 60 kDa heat shock protein, mitochondrial HSPD1 Homo sapiens 386.96 31.59 14 101 P38646 Stress-70 protein, mitochondrial HSPA9 Homo sapiens 378.75 21.50 11 100 Q14204 Cytoplasmic dynein 1 heavy Chain 1 DYNC1H1 Homo sapiens 360.00 9.00 29 100 P35556 Fibrillin-2 FBN2 Homo sapiens 371.59 8.04 15 97 P67936 Tropomyosin alpha-4 chain TPM4 Homo sapiens 342.85 47.98 13 96 P23284 Peptidyl-prolyl cis-trans isomerase B PPIB Homo sapiens 305.17 40.28 9 96 P26038 Moesin MSN Homo sapiens 353.35 26.34 15 95 P25705 ATP synthase subunit alpha, mitochondrial ATP5A1 Homo sapiens 358.61 25.86 10 94 O00299 Chloride intracellular channel protein 1 CLIC1 Homo sapiens 355.52 68.88 12 94 P27757 Calreticulin CALR Homo sapiens 386.83 39.57 10 92 P42330 Aldo-keto reductase family 1 member C3 AKR1C3 Homo sapiens 386.79 42.72 9 92 P09382 Galectin-1 LGALS1 Homo sapiens 336.73 46.67 5 92 P07195 L-lactate dehydrogenase B chain LDHB Homo sapiens 301.77 37.72 12 92 Q6NZ12 Polymerase I and transcript release factor PTRF Homo sapiens 366.06 25.38 8 91 Q13813 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Homo sapiens 349.51 13.43 21 91 P23528 Cofilin-1 CFL1 Homo sapiens 381.58 57.83 10 90 P36955 Pigment epithelium-derived factor SERPINF1 Homo sapiens 334.75 22.01 7 90 P51149 Ras-related protein Rab-7a RAB7A Homo sapiens 325.35 60.87 10 90 P07858 Cathepsin B CTSB Homo sapiens 373.17 31.27 9 89 P27824 Calnexin CANX Homo sapiens 339.30 23.65 11 89 P40926 Malate dehydrogenase, mitochondrial MDH2 Homo sapiens 319.47 44.38 11 89 P51884 Lumican LUM Homo sapiens 289.27 32.25 9 89 P53396 ATP-citrate synthase ACLY Homo sapiens 328.72 19.71 14 86 P40939 Trifunctional enzyme subunit alpha, HADHA Homo sapiens 340.14 17.96 8 83 mitochondrial Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP10 FKBP10 Homo sapiens 271.61 19.42 9 81 P02792 Ferritin light chain FTL Homo sapiens 388.87 36.00 5 80 P30041 Peroxiredoxin-6 PRDX6 Homo sapiens 281.65 48.66 9 80 P60842 Eukaryotic initiation factor 4A-1 EIF4A1 Homo sapiens 263.67 33.50 11 80 Q15084 Protein disulfide-isomerase A6 PDIA6 Homo sapiens 288.09 29.32 8 79 P04264 keratin, type II cytoskeletal 1 KRT1 Homo sapiens 271.98 18.48 10 79 P07686 Beta-hexosaminidase subunit beta HEXB Homo sapiens 232.74 13.31 6 79 P49368 T-Complex protein 1 subunit gamma CCT3 Homo sapiens 283.18 29.17 11 78 P09211 Glutathione S-transferase P GSTP1 Homo sapiens 330.61 53.33 8 77 P37802 Transgelin-2 TAGLN2 Homo sapiens 299.87 57.29 9 77 P16278 Beta-galactosidase GLB1 Homo sapiens 281.54 24.37 11 77 P21796 Voltage-dependent anion-selective channel VDAC1 Homo sapiens 304.95 27.21 6 76 protein 1 P63244 Guanine nucleotide-binding protein subunit GNB2L1 Homo sapiens 273.34 55.84 11 76 beta-2-like 1 P11766 Alcohol dehydrogenase class-3 ADH5 Homo sapiens 338.18 22.99 6 74 P05388 60S acidic ribosomal protein P0 RPLP0 Homo sapiens 303.07 37.85 8 74 Q96AG4 Leucine-rich repeat-containing protein 59 LRRC59 Homo sapiens 280.57 31.60 6 74 Q07954 Prolow-density lipoprotein receptor-related LRP1 Homo sapiens 276.43 4.91 15 71 protein 1 P08865 40S ribosomal protein SA RPSA Homo sapiens 274.72 36.61 8 71 P61981 14-3-3 protein gamma YWHAG Homo sapiens 224.58 28.74 6 71 P26641 Elongation factor 1-gamma EEF1G Homo sapiens 271.89 28.60 11 70 O60664 Perilipin-3 PLIN3 Homo sapiens 268.33 35.02 9 70 O01082 Spectrin beta chain, non-erythrocytic 1 SPTBN1 Homo sapiens 239.23 11.59 18 70 P09525 Annexin A4 ANXA4 Homo sapiens 228.82 34.80 9 70 O75083 WD repeat-containing protein 1 WDR1 Homo sapiens 358.76 26.73 9 69 O96D15 Reticulocalbin-3 RCN3 Homo sapiens 299.70 30.79 6 69 Q9Y6N5 Sulfide quinone oxidoreductase, SQRDL Homo sapiens 253.49 28.00 10 69 mitochondrial P07996 Thrombospondin-1 THBS1 Homo sapiens 241.05 14.36 10 69 P40925 Malate dehydrogenase, cytoplasmic MDH1 Homo sapiens 231.53 25.15 6 68 Q15019 Septin-2 41884 Homo sapiens 267.59 42.66 9 67 Q15385 Poly(rC)-binding protein 1 PCBP1 Homo sapiens 231.29 26.93 5 67 P07737 Profilin-1 PFN1 Homo sapiens 216.78 63.57 7 67 P62820 Ras-related protein Rab-1A RAB1A Homo sapiens 206.51 51.22 8 67 P06744 Glucose-6-phosphate isomerase GPI Homo sapiens 266.65 29.57 10 66 P22314 Ubiquitin-like modifier-activating enzyme 1 UBA1 Homo sapiens 250.03 20.42 14 66 P12882 Myosin-1 MYH1 Homo sapiens 235.28 11.55 17 65 P07339 Cathepsin D CTSD Homo sapiens 209.54 31.07 9 65 P18085 ADP-ribosylation factor 4 ARF4 Homo sapiens 201.61 60.56 9 65 P04844 Dolichyl-diphosphooligosaccharide-protein RPN2 Homo sapiens 298.04 23.61 10 64 glycosyltransferase subunit 2 Q03135 Caveolin-1 CAV1 Homo sapiens 225.24 52.25 7 64 P04792 Heat shock protein beta-1 HSPB1 Homo sapiens 217.66 39.51 7 64 P45880 Voltage-dependent anion-selective channel VDAC2 Homo sapiens 212.61 32.99 7 64 protein 2 P60660 Myosin light polypeptide 6 MYL6 Homo sapiens 206.89 48.34 7 64 P08107 Heat shock 70 kDa protein 1A/1B HSPA1A Homo sapiens 205.34 19.81 9 64 P02794 Ferritin heavy chain FTH1 Homo sapiens 276.77 51.91 7 63 Q01518 Adenylyl cyclase-associated protein 1 CAP1 Homo sapiens 232.42 30.95 11 63 P21980 Protein-glutamine gamma- TGM2 Homo sapiens 232.14 15.43 7 63 glutamyltransferase 2 P05387 60S acidic ribosomal protein P2 RPLP2 Homo sapiens 256.84 69.57 4 62 Q15293 Reticulocalbin-1 RCN1 Homo sapiens 254.49 37.16 7 62 P04843 Dolichyl-diphosphooligosaccharide-protein RPN1 Homo sapiens 235.08 30.81 12 62 glycosyltransferase subunit 1 P55786 Puromycin-sensitive aminopeptidase NPEPPS Homo sapiens 200.99 13.93 10 62 Q9Y6C2 EMILIN-1 EMILIN1 Homo sapiens 210.60 14.76 11 60 P31946 14-3-3 protein beta/alpha YWHAB Homo sapiens 189.82 28.46 5 60 P07108 Acyl-CoA-binding protein DBI Homo sapiens 235.46 50.57 3 59 P50395 Rab GDP dissociation inhibitor beta GDI2 Homo sapiens 221.44 41.80 12 59 P15121 Aldose reductase AKR1B1 Homo sapiens 216.09 36.39 7 59 P61978 Heterogeneous nuclear ribonucleoprotein K HNRNPK Homo sapiens 211.91 29.59 10 59 P53618 Coatomer subunit beta COPB1 Homo sapiens 199.75 18.68 11 59 P62241 40S ribosomal protein S8 RPS8 Homo sapiens 201.29 41.35 7 58 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 Homo sapiens 199.18 10.24 9 58 P30044 Peroxiredoxin-5, mitochondrial PRDX5 Homo sapiens 186.74 50.00 7 58 P36578 60S ribosomal protein L4 RPL4 Homo sapiens 178.67 14.75 5 58 P61158 Actin-related protein 3 ACTR3 Homo sapiens 237.38 34.93 9 57 Q9NQC3 Reticulon-4 RTN4 Homo sapiens 227.04 9.65 6 57 P11216 Glycogen phosphorylase, brain form PYGB Homo sapiens 208.18 18.86 11 57 Q14108 Lysosome membrane protein 2 SCARB2 Homo sapiens 200.13 19.46 6 57 P23396 40S ribosomal protein S3 RPS3 Homo sapiens 172.16 52.26 10 57 P68871 Hemoglobin subunit beta HBB Homo sapiens 165.75 59.86 7 57 P12236 ADP/ATP translocase 3 SLC25A6 Homo sapiens 161.18 21.81 6 57 O60701 UDP-glucose 6-dehydrogenase UGDH Homo sapiens 218.40 38.06 13 56 P00387 NADH-cytochrome b5 reductase 3 CYB5R3 Homo sapiens 205.94 53.16 9 56 P30050 60S ribosomal protein L12 RPL12 Homo sapiens 202.07 54.55 6 56 P35237 Serpin B6 SERPINB6 Homo sapiens 201.97 32.18 9 56 Q96KK5 Histone H2A type 1-H HIST1H2AH Homo sapiens 198.46 27.34 3 56 P61204 ADP-ribosylation factor 3 ARF3 Homo sapiens 186.09 50.28 7 56 P63241 Eukaryotic translation initiation factor 5A-1 EIF5A Homo sapiens 251.09 27.27 4 55 P49748 Very long-chain specific acyl-CoA ACADVL Homo sapiens 226.83 16.64 7 55 dehydrogenase, mitochondrial P50995 Annexin A11 ANXA11 Homo sapiens 186.26 12.87 5 55 P53621 Coatomer subunit alpha COPA Homo sapiens 169.57 12.01 10 55 P52209 6-Phosphogluconate dehydrogenase, PGD Homo sapiens 219.84 20.50 7 54 decarboxylating P30086 Phosphatidylethanolamine-binding protein 1 PEBP1 Homo sapiens 214.04 64.71 7 54 Q9H299 SH3 domain-binding glutamic acid-rich-like SH3BGRL3 Homo sapiens 210.88 31.18 3 54 protein 3 P17655 Calpain-2 catalytic subunit CAPN2 Homo sapiens 196.98 18.86 9 54 P22392 Nucleoside diphosphate kinase B NME2 Homo sapiens 185.09 52.63 6 54 Q15582 Transforming growth factor-beta-induced TGFBI Homo sapiens 171.73 7.91 4 54 protein ig-h3 Q14697 Neutral alpha-glucosidase AB GANAB Homo sapiens 244.51 13.35 9 53 P09972 Fructose-bisphosphate aldolase C ALDOC Homo sapiens 233.02 18.41 4 53 Q9Y696 Chloride intracellular channel protein 4 CLIC4 Homo sapiens 225.06 67.98 12 53 P13667 Protein disulfide-isomerase A4 PDIA4 Homo sapiens 216.49 17.05 8 53 P78527 DNA-dependent protein kinase catalytic PRKDC Homo sapiens 203.70 5.28 14 53 subunit P31939 Bifunctional purine biosynthesis protein ATIC Homo sapiens 188.54 15.71 7 52 PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase] P02768 Serum albumin ALB Homo sapiens 201.86 3.94 3 51 P52565 Rho GDP-dissociation inhibitor 1 ARHGDIA Homo sapiens 186.59 21.08 4 51 P52907 F-actin-capping protein subunit alpha-1 CAPZA1 Homo sapiens 181.06 41.26 7 51 O75874 Isocitrate dehydrogenase [NADP] IDH1 Homo sapiens 167.93 27.78 9 51 cytoplasmic P14550 Alcohol dehydrogenase [NADP(+)] AKR1A1 Homo sapiens 176.30 23.38 7 50 P22626 Heterogeneous nuclear ribonucleoproteins HNRNPA2B1 Homo sapiens 166.97 28.05 8 50 A2/B1 P41250 Glycine-tRNA ligase GARS Homo sapiens 161.46 14.21 7 50 P12956 X-ray repair cross-complementing protein 6 XRCC6 Homo sapiens 156.89 23.15 10 50 Q04446 1,4-alpha-glucan-branching enzyme GBE1 Homo sapiens 206.81 20.66 9 49 Q6IUX7 Adipocyte enhancer-binding protein 1 AEBP1 Homo sapiens 205.43 10.71 8 49 P00367 Glutamate dehydrogenase 1, mitochondrial GLUD1 Homo sapiens 193.31 16.31 6 49 P24534 Elongation factor 1-beta EEF1B2 Homo sapiens 183.36 28.44 5 49 P42224 Signal transducer and activator of STAT1 Homo sapiens 176.41 20.80 12 49 transcription 1-alpha/beta P55209 Nucleosome assembly protein 1-like 1 NAP1L1 Homo sapiens 200.78 14.58 4 48 Q9Y678 Coatomer subunit gamma-1 COPG1 Homo sapiens 196.07 12.36 7 48 P14314 Glucosidase 2 subunit beta PRKCSH Homo sapiens 180.64 14.58 6 48 Q96CX2 BTB/POZ domain-containing protein KCTD12 FMOD Homo sapiens 136.59 14.77 4 47 P50609 Fibromodulin KCTD12 Rattus norvegicus 170.37 19.68 5 47 P50990 T-complex protein 1 subunit theta CCT8 Homo sapiens 149.29 17.34 7 46 P10599 Thioredoxin TXN Homo sapiens 149.25 31.43 4 46 P30153 Serine/threonine-protein phosphatase 2A 65 kDa PPP2R1A Homo sapiens 182.68 18.51 7 45 regulatory subunit A alpha isoform P55084 Trifunctional enzyme subunit beta, HADHB Homo sapiens 171.75 23.21 7 45 mitochondrial P62158 Calmodulin CALM1 Homo sapiens 183.48 44.30 5 44 P32119 Peroxiredoxin-2 PRDX2 Homo sapiens 160.79 14.65 3 44 P49411 Elongation factor Tu, mitochondrial TUFM Homo sapiens 161.57 15.27 4 43 P62979 Ubiquitin-40S ribosomal protein S27a RPS27A Homo sapiens 152.11 33.97 4 43 O00159 Unconventional myosin-Ic MYO1C Homo sapiens 151.42 14.58 11 43 P34932 Heat shock 70 kDa protein 4 HSPA4 Homo sapiens 149.37 15.95 9 43 Q9P2E9 Ribosome-binding protein 1 RRBP1 Homo sapiens 147.57 11.70 10 43 Q99497 Protein DJ-1 PARK7 Homo sapiens 164.37 42.33 6 42 P62701 40S ribosomal protein S4, X isoform RPS4X Homo sapiens 150.60 29.66 7 42 P29692 Elongation factor 1-delta EEF1D Homo sapiens 136.02 32.38 7 42 Q8NBS9 Thioredoxin domain-containing protein 5 TXNDC5 Homo sapiens 165.03 18.98 6 41 P19105 Myosin regulatory light chain 12A MYL12A Homo sapiens 161.76 39.18 5 41 Q14974 Importin subunit beta-1 KPNB1 Homo sapiens 157.88 19.18 11 41 P39687 Acidic leucine-rich nuclear phosphoprotein 32 ANP32A Homo sapiens 137.22 12.85 3 41 family member A P30048 Thioredoxin-dependent peroxide reductase, PRDX3 Homo sapiens 222.53 28.91 4 40 mitochondrial P47755 F-actin-capping protein subunit alpha-2 CAPZA2 Homo sapiens 156.24 23.43 4 40 P17931 Galectin-3 LGALS3 Homo sapiens 154.89 25.60 5 40 P09651 Heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 Homo sapiens 142.70 22.31 6 40 P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 Homo sapiens 139.93 21.96 6 40 P07384 Calpain-1 catalytic subunit CAPN1 Homo sapiens 135.52 9.24 5 40 O95782 AP-2 complex subunit alpha-1 AP2A1 Homo sapiens 134.84 13.20 9 40 P48444 Coatomer subunit delta ARCN1 Homo sapiens 132.91 15.46 5 40 P04080 Cystatin-B CSTB Homo sapiens 158.66 45.92 3 39 O43390 Heterogeneous nuclear ribonucleoprotein R HNPNPR Homo sapiens 142.15 8.53 4 39 P61247 40S ribosomal protein S3a RPS3A Homo sapiens 133.56 18.18 4 39 P04899 Guanine nucleotide-binding protein G(i) GNAI2 Homo sapiens 131.68 17.18 4 39 subunit alpha-2 Q16658 Fascin FSCN1 Homo sapiens 167.69 26.37 9 38 Q07021 Complement component 1 Q subcomponent- C1QBP Homo sapiens 166.75 12.06 3 38 binding protein, mitochondrial P62829 60S ribosomal protein L23 RPL23 Homo sapiens 162.51 25.00 2 38 P07099 Epoxide hydrolase 1 EPHX1 Homo sapiens 158.47 27.47 9 38 P50991 T-complex protein 1 subunit delta CCT4 Homo sapiens 151.63 10.76 4 38 P27105 Erythrocyte band 7 integral membrane STOM Homo sapiens 142.49 41.32 7 38 protein P15559 NAD(P)H dehydrogenase [quinone] 1 NQO1 Homo sapiens 141.57 17.15 4 38 Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU Homo sapiens 135.88 15.03 7 38 P27816 Microtubule-associated protein 4 MAP4 Homo sapiens 125.87 9.64 7 38 P00966 Argininosuccinate synthase ASS1 Homo sapiens 125.52 14.81 4 38 P19338 Nucleolin NCL Homo sapiens 125.15 13.66 8 38 P37837 Transaldolase TALDO1 Homo sapiens 121.68 14.24 4 38 P06753 Tropomyosin alpha-3 chain TPM3 Homo sapiens 119.22 13.38 5 38 Q15366 Poly(rC)-binding protein 2 PCBP2 Homo sapiens 118.11 11.78 3 38 Q01129 Decorin DCN Rattus norvegicus 107.47 18.64 6 38 P06748 Nucleophosmin NPM1 Homo sapiens 144.28 24.49 8 37 P62906 60S ribosomal protein L10a RPL10A Homo sapiens 141.74 25.81 4 37 Q12797 Aspartyl/asparaginyl beta-hydroxylase ASPH Homo sapiens 139.39 15.44 8 37 P16615 Sarcoplasmic/endoplasmic reticulum calcium ATP2A2 Homo sapiens 124.62 9.12 7 37 ATPase 2 P46782 40S ribosomal protein S5 [Cleaved into: 40S RPS5 Homo sapiens 122.17 17.65 3 37 ribosomal protein S5, N-terminally processed] Q07020 60S ribosomal protein L18 RPL18 Homo sapiens 117.66 30.85 5 37 P50914 60S ribosomal protein L14 RPL14 Homo sapiens 109.86 15.35 3 37 P62244 40S ribosomal protein S15a RPS15A Homo sapiens 138.62 30.00 4 36 P13645 Keratin, type I cytoskeletal 10 KRT10 Homo sapiens 117.06 21.40 9 36 P56134 ATP synthase subunit 1, mitochondrial ATP5J2 Homo sapiens 110.17 25.53 2 36 P07910 Heterogeneous nuclear ribonucleoproteins HNRNPC Homo sapiens 102.07 15.03 4 36 C1/C2 P78371 T-complex protein 1 subunit beta CCT2 Homo sapiens 159.70 25.61 9 35 P05534 HLA class I histocompatibility antigen, A-24 HLA-A Homo sapiens 127.63 30.14 7 35 alpha chain P62888 60S ribosomal protein L30 RPL30 Homo sapiens 127.35 34.78 3 35 Q16698 2,4-dienoyl-CoA reductase, mitochondrial DECR1 Homo sapiens 112.19 17.91 4 35 Q9Y265 RuvB-like 1 RUVBL1 Homo sapiens 110.51 23.03 7 35 P42785 Lysosomal Pro-X carboxypeptidase PRCP Homo sapiens 118.66 9.48 3 34 Q969G5 Protein kinase C delta-binding protein PRKCDBP Homo sapiens 114.93 17.24 4 34 P62424 60S ribosamal protein L7a RPL7A Homo sapiens 105.69 15.04 4 34 P60981 Destrin DSTN Homo sapiens 102.99 20.00 3 34 P62879 Guanine nucleotide-binding protein GNB2 Homo sapiens 98.15 15.29 4 34 G(I)/G(S)/G(T) subunit beta-2 Q92743 Serine protease HTRA1 HTRA1 Homo sapiens 97.18 11.25 5 34 P00441 Superoxide dismutase [CuZn] SOD1 Homo sapiens 191.85 32.47 4 33 Q15181 Inorganic pyrophosphatase PPA1 Homo sapiens 145.98 35.99 7 33 P63010 AP-2 complex subunit beta AP2B1 Homo sapiens 127.86 13.13 7 33 P15531 Nucleoside diphosphate kinase A NME1 Homo sapiens 123.53 51.97 6 33 P08473 Neprilysin MME Homo sapiens 120.47 13.07 7 33 P62826 GTP-binding nuclear protein Ran RAN Homo sapiens 117.10 34.26 6 33 P17980 26S protease regulatory subunit 6A PSMC3 Homo sapiens 110.28 21.41 6 33 Q43776 Asparagine--tRNA ligase, cytoplasmic NARS Homo sapiens 107.40 19.71 8 33 P15880 40S ribosomal protein S2 RPS2 Homo sapiens 101.99 19.45 5 33 P31949 Protein S100-A11 S100A11 Homo sapiens 93.44 40.95 4 33 P68036 Ubiquitin-conjugating enzyme E2L3 UBE2L3 Homo sapiens 143.93 35.71 3 32 P17301 Integrin alpha-2 ITGA2 Homo sapiens 128.38 6.77 5 32 P16070 CD44 antigen CD44 Homo sapiens 126.71 3.77 2 32 P69905 Hemoglobin subunit alpha HBA1; Homo sapiens 115.45 28.17 3 32 P61106 Ras-related protein Rab-14 RAB14 Homo sapiens 104.55 16.74 3 32 P62249 40S ribosomal protein S16 RPS16 Homo sapiens 89.33 20.55 3 32 Q16851 UTP-glucose-1-phosphate UGP2 Homo sapiens 150.43 12.60 4 31 uridylyltransferase P60033 CD81 antigen CD81 Homo sapiens 144.01 25.00 3 31 P23142 Fibulin-1 FBLN1 Homo sapiens 139.79 20.91 7 31 P28066 Proteasome subunit alpha type-5 PSMA5 Homo sapiens 127.88 35.27 5 31 P49755 Transmembrane emp24 domain-containing TMED10 Homo sapiens 125.42 16.89 3 31 protein 10 Q06323 Proteasome activator-complex subunit 1 PSME1 Homo sapiens 110.60 27.71 8 31 Q13838 Spliceosome RNA helicase DDX39B DDX39B Homo sapiens 104.76 22.43 6 31 P61586 Transforming protein Rho RHOA Homo sapiens 103.88 32.64 5 31 P78539 Sushi repeat-containing protein SRPX SRPX Homo sapiens 94.78 7.76 3 31 P15586 N-acetyglucosamine-6-sulfatase GNS Homo sapiens 93.73 11.23 4 31 P59998 Actin-related protein 2/3 complex subunit 4 ARPC4 Homo sapiens 92.41 35.71 5 31 Q9BSJ8 Extended synaptotagmin-1 ESYT1 Homo sapiens 92.29 7.34 6 31 P25396 40S ribosomal protein S12 RPS12 Homo sapiens 129.03 31.82 3 30 Q5T9L3 Protein wntless homolog WLS Homo sapiens 127.49 9.80 4 30 P20810 Calpastatin CAST Homo sapiens 124.88 10.88 4 30 P00325 Alcohol dehydrogenase 1B ADH1B Homo sapiens 118.70 26.67 7 30 P23219 Prostaglandin G/H synthase 1 PTGS1 Homo sapiens 113.71 12.85 5 30 Q00325 Phosphate carrier protein, mitochondrial SLC25A3 Homo sapiens 102.13 19.06 5 30 P45926 Glucosemine-6-phosphate isomerase 1 GNPDA1 Homo sapiens 93.67 21.11 4 30 P28838 Cytosol aminopeptidase LAP3 Homo sapiens 120.58 14.64 5 29 P17858 5-phosphofructokinase, liver type PFKL Homo sapiens 112.91 14.49 8 29 Q96TA1 Niban-like protein 1 FAM129B Homo sapiens 108.73 14.88 7 29 P62277 40S ribosomal protein S13 RPS13 Homo sapiens 106.57 18.54 3 29 Q96QK1 Vacuolar protein sorting-associated protein VPS35 Homo sapiens 100.71 12.06 7 29 35 P39019 40S ribosomal protein S19 RPS19 Homo sapiens 94.38 30.34 6 29 Q13162 Peroxiredoxin-4 PRDX4 Homo sapiens 93.42 37.64 7 29 Q14103 Heterogeneous nuclear ritonucleoprotein D0 HNRNPD Homo sapiens 85.53 14.65 4 29 Q6NXT2 Histone H3.3C H3F3C Homo sapiens 77.14 11.85 2 29 P26599 Polypyrimidine tract-binding protein 1 PTBP1 Homo sapiens 129.28 12.62 4 28 P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Homo sapiens 129.28 29.63 3 28 P18124 60S ribosomal protein L7 RPL7 Homo sapiens 105.73 23.39 4 26 P98160 Basement membrane-specific heparan HSPG2 Homo sapiens 104.99 2.37 7 28 sulfate proteoglycan core protein P62140 Serine/threonine-protein phosphatase PP1- PPP1CB Homo sapiens 102.12 18.96 5 28 beta catalytic subunit P51686 N-sulphoglucosamine sulphohydrolase SGSH Homo sapiens 101.57 8.37 3 28 P21399 Cytoplasmic aconitate hydratase ACO1 Homo sapiens 98.99 11.81 7 28 P08253 72 kDa type IV collagenase MMP2 Homo sapiens 95.34 10.91 4 28 O00571 ATP-dependent RNA helicase DDX3X DDX3X Homo sapiens 91.46 9.67 5 28 O9Y2Q3 Glutathione S-transferase kappa 1 GSTK1 Homo sapiens 90.89 33.63 6 28 P35232 Prohibitin PHB Homo sapiens 88.99 28.31 6 28 Q9Y277 Voltage-dependent anion-selective channel VDAC3 Homo sapiens 81.75 14.49 3 28 protein 3 P51659 Peroxisomal multifunctional enzyme type 2 HSD17B4 Homo sapiens 106.47 10.87 5 27 Q05682 Caldesmon CALD1 Homo sapiens 85.52 5.17 4 27 P46783 40S ribosomal protein S10 RPS10 Homo sapiens 86.11 14.55 2 27 P83731 60S ribosomal protein L24 RPL24 Homo sapiens 80.95 20.38 3 27 P30040 Endoplasmic reticulum resident protein 29 ERP29 Homo sapiens 73.20 14.18 3 27 P62269 40S ribosomal protein S18 RPS18 Homo sapiens 71.59 16.45 3 27 Q96HE7 ERO1-like protein alpha ERO1L Homo sapiens 114.32 22.44 6 26 Q16181 Septin-7 41889 Homo sapiens 100.36 21.97 6 26 P43235 Cathepsin K CTSK Homo sapiens 99.90 19.45 3 26 P40261 Nicotinamide N-methyltransferase NNMT Homo sapiens 99.01 21.97 4 26 O43399 Tumor protein D54 TPD52L2 Homo sapiens 96.02 36.41 5 26 P21266 Glutathione S-transferase Mu 3 ALB Homo sapiens 84.67 22.67 4 26 P08962 CD63 antigen GSTM3 Homo sapiens 72.76 7.56 2 26 P02770 Serum albumin CD63 Rattus norvegicus 93.78 4.28 2 26 P22695 Cytochrome b-c1 complex subunit 2, UQCRC2 Homo sapiens 104.25 16.78 5 25 mitochondrial P39023 60S ribosomal protein L3 RPL3 Homo sapiens 103.60 20.84 6 25 Q00341 Vigilin HDLBP Homo sapiens 103.20 4.10 3 25 Q01813 6-phosphofructokinase type C PFKP Homo sapiens 97.67 13.14 6 25 P12955 Xaa-Pro dipeptidase PEPD Homo sapiens 92.15 8.32 3 25 P27487 Dipeptidyl peptidase 4 DPP4 Homo sapiens 90.72 10.44 6 25 P05413 Fatty acid-binding protein, heart FABP3 Homo sapiens 88.34 45.86 6 25 P35908 Keratin, type II cytoskeletal 2 epidermal KRT2 Homo sapiens 85.90 11.58 6 25 P21589 5-nucleotidase NT5E Homo sapiens 85.75 15.85 6 25 O75915 PRA1 family protein 3 ARL6IP5 Homo sapiens 81.97 15.96 2 25 P05556 Integrin beta-1 ITGB1 Homo sapiens 80.76 6.02 4 25 Q8WUW4 Programmed cell death 6-interacting protein PDCD6IP Homo sapiens 74.74 7.37 5 25 P78417 Glutathione S-transferase omega-1 GSTO1 Homo sapiens 74.27 7.88 2 25 P46781 40S ribosomal protein S9 RPS9 Homo sapiens 68.19 13.40 3 25 P14866 Heterogeneous nuclear ribonucleoprotein L HNRNPL Homo sapiens 123.31 8.66 2 24 P40227 T-complex protein 1 subunit zeta CCT6A Homo sapiens 112.14 25.05 7 24 Q12905 Interleukin enhancer-binding factor 2 ILF2 Homo sapiens 105.67 12.82 3 24 Q7KZF4 Staphylococcal nuclease domain-containing SND1 Homo sapiens 99.88 13.19 7 24 protein 1 P02765 Alpha-2-HS-glycoprotein AHSG Homo sapiens 90.57 5.45 2 24 O60506 Heterogeneous nuclear ribonucleoprotein Q SYNCRIP Homo sapiens 90.57 11.88 5 24 P23634 Plasma membrane calcium-transporting ATP284 Homo sapiens 85.12 2.50 2 24 ATPase 4 P10155 60 kDa SS-A/Ro ribonucleoprotein TROVE2 Homo sapiens 79.15 4.46 2 24 O00231 26S proteasome non-ATPase regulatory PSMD11 Homo sapiens 75.89 8.77 3 24 subunit 11 P61088 Ubiquiltin-conjugating enzyme E2 N UBE2N Homo sapiens 71.94 41.45 5 24 P05386 60S acidic ribosomal protein P1 RPLP1 Homo sapiens 110.40 51.75 2 23 O15460 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 Homo sapiens 101.78 12.90 5 23 P13693 Translationally-controlled tumor protein TPT1 Homo sapiens 94.17 12.21 2 23 P10620 Microsomal glutathione S-transferase 1 MGST1 Homo sapiens 89.77 27.10 3 23 Q99623 Prohibitin-2 PHB2 Homo sapiens 82.71 25.42 6 23 P61604 10 kDa heat shock protein, mitochondrial HSPE1 Homo sapiens 82.34 25.49 2 23 Q8NHP8 Putative phospholipase B-like 2 PLBD2 Homo sapiens 81.14 8.49 4 23 P35754 Glutaredoxin-1 GLRX Homo sapiens 75.29 30.19 2 23 P17987 T-complex protein 1 subunit alpha TCP1 Homo sapiens 66.48 8.45 4 23 P16403 Histone H1.2 HIST1H1C Homo sapiens 63.40 19.72 4 23 P01033 Metalloproteinase inhibitor 1 TIMP1 Homo sapiens 90.30 28.02 4 22 P60866 40S ribosomal protein S20 RPS20 Homo sapiens 87.96 19.33 2 22 P04179 Superoxide dismutase [Mn], mitochondrial SOD2 Homo sapiens 84.22 22.97 4 22 P01889 HLA class I histocompatibility antigen, B-7 HLA-B Homo sapiens 80.41 20.72 5 22 alpha chain Q9UBG0 C-type mannose receptor 2 MRC2 Homo sapiens 79.01 4.12 4 22 O94979 Protein transport protein Sec31A SEC31A Homo sapiens 75.45 4.67 4 22 P07711 Cathepsin L1 CTSL Homo sapiens 72.15 8.41 2 22 P25789 Proteasome subunit alpha type-4 PSMA4 Homo sapiens 67.06 21.46 3 22 P61160 Actin-related protein 2 ACTR2 Homo sapiens 63.07 12.94 4 22 Q9UHD8 Septin-9 41891 Homo sapiens 62.81 13.14 5 22 P35268 60S ribosomal protein L22 RPL22 Homo sapiens 62.65 18.75 2 22 P30084 Enoyl-CoA hydratase, mitochondrial ECHS1 Homo sapiens 96.93 19.31 3 21 O14773 Tripeptidyl-peptidase 1 TPP1 Homo sapiens 81.36 8.17 3 21 P62333 26S protease regulatory subunit 10B PSMC6 Homo sapiens 79.86 11.83 3 21 P54709 Sodium/potassium-transporting ATPase ATP1B3 Homo sapiens 76.45 17.20 3 21 subunit beta-3 P13010 X-ray repair cross-complementing protein 5 XRCC5 Homo sapiens 76.09 11.34 5 21 P39656 Dolichyl-diphosphooligosaccharide-protein DDOST Homo sapiens 75.49 16.23 5 21 glycosyltransferase 48 kDa subunit Q16881 Thioredoxin reductase 1, cytoplasmic TXNRD1 Homo sapiens 73.59 10.02 4 21 Q9NR45 Sialic acid synthase NANS Homo sapiens 73.04 15.88 3 21 P13674 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 Homo sapiens 72.31 14.98 6 21 P47756 F-actin-capping protein subunit beta CAPZB Homo sapiens 71.92 20.94 4 21 P61313 60S ribosomal protein L15 RPL15 Homo sapiens 70.62 17.16 3 21 P11047 Laminin subunit gamma-1 LAMC1 Homo sapiens 66.17 5.90 7 21 P51148 Ras-related protein Rab-5C RAB5C Homo sapiens 63.90 23.15 4 21 O75390 Citrate synthase, mitochondrial CS Homo sapiens 60.12 7.73 3 21 P62263 40S ribosomal protein S14 RPS14 Homo sapiens 87.52 21.19 2 20 Q13724 Mannosyl-oligosaccharide glucosidase MOGS Homo sapiens 84.85 3.58 2 20 P36543 V-type proton ATPase subunit E 1 ATP6V1E1 Homo sapiens 79.06 6.19 2 20 P13797 Plastin-3 PLS3 Homo sapiens 70.30 10.79 5 20 P54920 Alpha-soluble NSF attachment protein NAPA Homo sapiens 68.68 28.47 6 20 P27635 60S ribosomal protein L10 RPL10 Homo sapiens 64.27 23.83 3 20 Q04760 Lactoylglutathione lyase GLO1 Homo sapiens 63.58 14.67 2 20 P26640 Valine-tRNA ligase VARS Homo sapiens 62.47 3.88 4 20 O94905 Erlin-2 ERLIN2 Homo sapiens 61.85 16.81 4 20 O14979 Heterogeneous nuclear ribonucleoprotein D- HNRNPDL Homo sapiens 61.35 9.76 3 20 like P13473 Lysosome-associated membrane LAMP2 Homo sapiens 57.75 7.07 3 20 glycoprotein 2 P11940 Polyadenylate-binding protein 1 PABPC1 Homo sapiens 56.47 9.91 5 20 P20340 Ras-related protein Rab-6A RAB6A Homo sapiens 54.52 22.12 4 20 P62318 Small nuclear ribonucleoprotein Sm D3 SNRPD3 Homo sapiens 53.58 15.08 2 20 Q99460 26S proteasome non-ATPase regulatory PSMD1 Homo sapiens 109.07 5.46 3 19 subunit 1 Q9BS26 Endoplasmic reticulum resident protein 44 ERP44 Homo sapiens 90.29 15.27 4 19 Q15185 Prostaglandin E synthase 3 PTGES3 Homo sapiens 87.82 18.13 2 19 P29373 Cellular retinoic acid-binding protein 2 CRABP2 Homo sapiens 84.96 34.78 4 19 P20618 Proteasome subunit beta type-1 PSMB1 Homo sapiens 79.58 21.16 3 19 Q9Y3I0 tRNA-splicing ligase RtcB homolog RTCB Homo sapiens 75.39 13.47 4 19 O14818 Proteasome subunit alpha type-7 PSMA7 Homo sapiens 74.40 28.63 4 19 P51636 Caveolin-2 CAV2 Homo sapiens 71.42 20.99 2 19 P35606 Coatomer subunit beta COPB2 Homo sapiens 67.84 10.49 6 19 Q15836 Vesicle-associated membrane protein 3 VAMP3 Homo sapiens 67.54 33.00 2 19 P21810 Biglycan BGN Homo sapiens 65.73 10.87 3 19 Q99715 Coliagen alpha-1(XII) chain COL12A1 Homo sapiens 63.88 3.40 7 19 Q13557 Calcium/calmodulin-dependent protein kinase CAMK2D Homo sapiens 63.08 16.03 5 19 type II subunit delta P00505 Aspartate aminotransferase, mitochandrial GOT2 Homo sapiens 60.55 14.42 5 19 P02786 Transferrin receptor protein 1 TFRC Homo sapiens 56.99 5.00 3 19 P04062 Glucosylceramidase GBA Homo sapiens 54.01 4.48 2 19 Q9NVA2 Septin-11 41893 Homo sapiens 51.50 8.86 3 19 Q8IWE2 Protein NOXP20 FAM114A1 Homo sapiens 76.12 14.03 5 18 Q9NVJ2 ADP-ribosylation factor-like protein 8B ARL8B Homo sapiens 72.50 34.95 5 18 P07814 Bifunctional glutamate/proline--tRNA ligase EPRS Homo sapiens 71.04 4.70 4 18 Q9UNM6 26S proteasome non-ATPase regulatory PSMD13 Homo sapiens 69.95 18.62 5 18 subunit 13 Q13200 26S proteasome non-ATPase regulatory PSMD2 Homo sapiens 68.87 9.47 6 18 subunit 2 Q07960 Rho GTPase-activating protein 1 ARHGAP1 Homo sapiens 68.44 14.35 4 18 P36957 Dihydrolipoyllysine-residue DLST Homo sapiens 66.31 12.80 4 18 succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial Q13492 Phosphatidylinositol-binding clathrin PICALM Homo sapiens 61.69 4.91 2 18 assembly protein P13804 Electron transfer flavoprotein subunit alpha, ETFA Homo sapiens 59.21 25.53 6 18 mitochondrial P62753 40S ribosomal protein S6 RPS6 Homo sapiens 57.11 18.88 4 18 P11279 Lysosome-associated membrane LAMP1 Homo sapiens 54.87 10.55 4 18 glycoprotein 1 Q15075 Early endosome antigen 1 EEA1 Homo sapiens 54.84 4.61 5 18 Q9UHA4 Ragulator complex protein LAMTOR3 LAMTOR3 Homo sapiens 53.15 30.65 2 18 P49773 Histidine triad nucleotide-binding protein 1 HINT1 Homo sapiens 114.80 53.97 3 17 P04632 Calpain small subunit 1 CAPNS1 Homo sapiens 72.67 44.40 5 17 Q9H4M9 EH domain-containing protein 1 EHD1 Homo sapiens 72.21 14.42 5 17 O75367 Core histone macro-H2A 1 E2AFY Homo sapiens 72.16 13.44 3 17 O15144 Actin-related protein 2/3 complex subunit 2 ARPC2 Homo sapiens 66.66 21.67 4 17 Q9NYU2 UDP-glucose:glycoprotein UGGT1 Homo sapiens 63.95 6.17 6 17 glucosyltransferase 1 Q9UIJ7 GTP:AMP phosphotransferase AK3, AK3 Homo sapiens 62.60 18.50 3 17 mitochondrial Q7L2H7 Eukaryotic translation initiation factor 3 EIF3M Homo sapiens 60.36 15.78 4 17 subunit M P62857 40S ribosomal protein S28 RPS28 Homo sapiens 58.87 33.33 2 17 Q02878 60S ribosomal protein L6 RPL6 Homo sapiens 58.47 15.63 3 17 Q15436 Protein transport protein Sec23A SEC23A Homo sapiens 57.10 3.53 2 17 P61224 Ras-related protein Rap-1b RAP1B Homo sapiens 57.06 27.72 4 17 P51571 Translocon-associated protein subunit delta SSR4 Homo sapiens 55.54 23.12 3 17 P26447 Protein S100-A4 S100A4 Homo sapiens 53.79 28.71 3 17 Q14847 LIM and SH3 domain protein 1 LASP1 Homo sapiens 53.29 21.84 5 17 Q12884 Seprase FAP Homo sapiens 52.54 7.63 5 17 P02795 Metallothionein-2 MT2A Homo sapiens 51.33 21.31 2 17 P38159 RNA-binding motif protein, X chromosome RBMX Homo sapiens 48.65 8.95 3 17 P62081 40S ribosomal protein S7 RPS7 Homo sapiens 77.61 38.66 4 16 P21964 Catechol O-methyltransferase COMT Homo sapiens 69.40 19.93 4 16 P48047 ATP synthase subunit O, mitochondrial ATP5O Homo sapiens 66.42 39.44 5 16 P62195 26S protease regulatory subunit 8 PSMC5 Homo sapiens 55.47 18.23 5 16 P20674 Cytochrome c oxidase subunit 5A, COX5A Homo sapiens 51.48 26.67 3 16 mitochondrial Q9UHG3 Prenylcysteine oxidase 1 PCYOX1 Homo sapiens 48.05 11.88 4 16 P10301 Ras-related protein R-Ras RRAS Homo sapiens 47.42 12.84 2 16 P20700 Lamin-B1 LMNB1 Homo sapiens 43.93 5.46 4 16 P37235 Hippocalcin-like protein 1 HPCAL1 Homo sapiens 40.95 17.10 3 16 P39060 Collagen alpha-1(XVIII) chain [Cleaved into: COL18A1 Homo sapiens 85.90 4.45 4 15 Endostetin] P63173 60S ribosomal protein L38 RPL38 Homo sapiens 73.59 35.71 2 15 O43242 26S proteasome non-APase regulatory PSMD3 Homo sapiens 65.74 7.68 3 15 subunit 3 P46777 60S ribosomal protein L5 RPL5 Homo sapiens 65.57 23.91 5 15 P63167 Dynein light chain 1, cytoplasmic DNYLL1 Homo sapiens 64.99 37.08 2 15 Q9BWD1 Acetyl-CoA acetyltransferase, cytosolic ACAT2 Homo sapiens 63.92 22.92 4 15 P19623 Spermidine synthase SRM Homo sapiens 63.90 37.09 6 15 P12268 Inosine-5-monophosphate dehydrogenase 2 IMPDH2 Homo sapiens 63.68 5.84 2 15 P61769 Beta-2-microglobulin [Cleaved into: Beta-2- B2M Homo sapiens 62.44 35.29 3 15 microglobulin from pI 5.3] P09622 Dihydrolipoyl dehydrogenase, mitochondrial DLD Homo sapiens 62.33 6.48 2 15 O95373 Importin-7 IPO7 Homo sapiens 61.73 4.43 3 15 P49257 Protein ERGIC-53 LMAN1 Homo sapiens 60.05 10.39 2 15 P00390 Glutathione reductase, mitochondrial GSR Homo sapiens 52.89 11.88 3 15 P61019 Ras-related protein Rab-2A RAB2A Homo sapiens 50.25 23.58 4 15 P23141 Liver carboxylesterase 1 CES1 Homo sapiens 50.07 7.58 3 15 O60763 General vesicular transport factor p115 USO1 Homo sapiens 49.72 6.24 4 15 Q9H8H3 Methyltransferase-like protein 7A METTL7A Homo sapiens 48.17 12.30 2 15 P09960 Leukotriene A-4 hydrolase LTA4H Homo sapiens 47.92 6.71 3 15 Q9UHL4 Dipeptidyl peptidase 2 DPP7 Homo sapiens 44.72 4.47 2 15 Q01995 Transgelin TAGLN Homo sapiens 44.12 21.39 3 15 P41252 Isoleucine--tRNA ligase, cytoplamic IARS Homo sapiens 39.65 3.49 4 15 P61970 Nuclear transport factor 2 NUTF2 Homo sapiens 66.79 33.86 2 14 Q92499 ATP-dependent RNA helicase DDX1 DDX1 Homo sapiens 66.78 7.43 3 14 O14980 Exportin-1 XPO1 Homo sapiens 65.25 5.23 3 14 P68402 Platelet-activating factor acetylhydrolase IB PAFAH1B2 Homo sapiens 53.86 20.96 3 14 subunit beta P31943 Heterogeneous nuclear ribonucleoprotein H HNRNPH1 Homo sapiens 52.62 14.25 4 14 P46778 60S ribosomal protein L21 RPL21 Homo sapiens 47.80 27.50 3 14 Q32P28 Prolyl 3-hydroxylase 1 LEPRE1 Homo sapiens 47.36 5.71 3 14 Q95816 BAG family molecular chaperone regulator 2 BAG2 Homo sapiens 46.92 13.27 2 14 Q92945 Far upstream element-binding protein 2 KHSRP Homo sapiens 45.76 5.63 3 14 P62847 40S ribosomal protein S24 RPS24 Homo sapiens 45.06 20.30 2 14 Q9ULV4 Coronin-1C CORO1C Homo sapiens 43.61 9.07 3 14 Q99584 Protein S100-A13 S100A13 Homo sapiens 43.40 23.47 2 14 Q9Y3A6 Transmembrane emp24 domain-containing TMED5 Homo sapiens 42.79 10.04 2 14 protein 5 P62750 60S ribosomal protein L23a RPL23A Homo sapiens 42.75 21.15 3 14 O15260 Surfeit locus protein 4 SURF4 Homo sapiens 42.65 11.90 3 14 P19404 NADH dehydrogenase [ubiquinone] NDUFV2 Homo sapiens 42.13 9.24 2 14 flavoprotein 2, mitochondrial P48681 Nestin NES Homo sapiens 39.33 1.48 2 14 Q9NQW7 Xaa-Pro aminopeptidase 1 XPNPEP1 Homo sapiens 38.25 4.82 2 14 Q99829 Copine-1 CPNE1 Homo sapiens 37.60 4.66 2 14 P06703 Protein S100-A6 S100A6 Homo sapiens 36.86 36.67 2 14 P61163 Alpha-centractin ACTR1A Homo sapiens 55.95 14.89 3 13 Q08211 ATP-dependent RNA helicase A DHX9 Homo sapiens 54.67 6.14 5 13 P38606 V-type proton ATPase catalytic subunit A ATP6V1A Homo sapiens 54.37 17.34 6 13 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Homo sapiens 54.15 31.03 4 13 P27701 CD82 antigen CD82 Homo sapiens 49.98 10.49 2 13 Q13765 Nascent polypeptide-associated complex NACA Homo sapiens 49.28 18.60 3 13 subunit alpha P14854 Cytochrome c oxidase subunit 6B1 COX6B1 Homo sapiens 48.91 47.67 3 13 P06756 Integrin alpha-V ITGAV Homo sapiens 45.52 11.45 7 13 P26373 60S ribosomal protein L13 RPL13 Homo sapiens 44.56 15.64 3 13 Q02809 Procollagen-lysine, 2-oxoglutarate 5- PLOD1 Homo sapiens 44.26 7.43 4 13 dioxygenase 1 P62899 60S ribosomal protein L31 RPL31 Homo sapiens 42.96 18.40 2 13 P60953 Cell division control protein 42 homolog CDC42 Homo sapiens 42.70 20.42 3 13 Q6NUM9 All-trans-retinol 13,14-reductase RETSAT Homo sapiens 41.53 4.92 2 13 Q01105 Protein SET SET Homo sapiens 40.71 18.28 4 13 P05455 Lupus La protein SSB Homo sapiens 39.96 12.50 4 13 P31948 Stress-induced-phosphoprotein 1 STIP1 Homo sapiens 39.18 7.73 3 13 P54136 Arginine-tRNA ligase, cyloplasmic RARS Homo sapiens 38.86 10.61 6 13 Q92841 Probable ATP-dependent RNA helicase DDX17 Homo sapiens 38.01 7.27 5 13 DDX17 P62330 ADP-ribosylation factor 6 ARF6 Homo sapiens 37.62 12.57 2 13 Q13228 Selenium-binding protein 1 SELENBP1 Homo sapiens 37.11 13.98 5 13 Q14152 Eukaryotic translation initiation factor 3 EIF3A Homo sapiens 37.07 4.27 5 13 subunit A P05023 Sodium/potassium-transporting ATPase ATP1A1 Homo sapiens 36.70 5.28 4 13 subunit alpha-1 Q70UQ0 Inhibitor of nuclear factor kappa-B kinase- IKBIP Homo sapiens 36.29 6.57 2 13 interacting protein O14579 Coatomer subunit epsilon COPE Homo sapiens 57.73 6.82 2 12 P46063 ATP-dependent DNA helicase Q1 RECQL Homo sapiens 51.17 6.63 3 12 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate GRHPR Homo sapiens 49.69 17.38 3 12 reductase Q07666 KH domain-containing, RNA-binding, signal KHDRBS1 Homo sapiens 47.70 7.67 2 12 transduction-associated protein 1 Q16363 Laminin subunit alpha-4 LAMA4 Homo sapiens 46.26 4.55 6 12 P46821 Microtubule-associated protein 1B MAP1B Homo sapiens 46.16 4.62 7 12 P24752 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Homo sapiens 42.51 9.84 3 12 O75368 SH3 domain-binding glutamic acid-rich-like SH3BGRL Homo sapiens 42.33 35.09 3 12 protein O95292 Vesicle-associated membrane protein- VAPB Homo sapiens 40.84 10.70 2 12 associated protein B/C Q13418 Integrin-linked protein kinase ILK Homo sapiens 40.30 14.38 4 12 P80303 Nucleobinding-2 NUCB2 Homo sapiens 40.20 7.14 2 12 P49589 Cysteine-tRNA ligase, cytoplasmic CARS Homo sapiens 40.10 4.68 2 12 Q9P2J5 Leucine-tRNA ligase, cytoplasmic LARS Homo sapiens 39.68 2.98 3 12 P23526 Adenosylhomocysteinase AHCY Homo sapiens 39.58 13.43 4 12 Q14112 Nidogen-2 NID2 Homo sapiens 39.09 7.71 6 12 P55884 Eukaryotic translation initiation factor 3 EIF3B Homo sapiens 38.13 5.90 4 12 subunit B O15145 Actin-related protein 2/3 complex subunit 3 ARPC3 Homo sapiens 37.32 13.48 2 12 P02649 Apolipoprotein E APOE Homo sapiens 37.22 8.52 2 12 P55795 Heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 Homo sapiens 36.67 10.47 3 12 Q99439 Calponin-2 CNN2 Homo sapiens 36.58 13.27 3 12 P62917 60S ribosomal protein L8 RPL8 Homo sapiens 34.54 25.29 5 12 P60900 Proteasome subunit alpha type-6 PSMA6 Homo sapiens 34.38 10.16 2 12 Q71UM5 40S ribosomal protein S27-like RPS27L Homo sapiens 33.77 38.10 3 12 Q03252 Lamin-B2 LMNB2 Homo sapiens 33.19 9.50 6 12 Q15323 Keratin, type I cuticular Ha1 KRT31 Homo sapiens 56.86 10.34 3 11 Q15121 Astrocytic phosphoprotein PEA-15 PEA15 Homo sapiens 54.65 27.69 3 11 Q6DD88 Atlastin-3 ATL3 Homo sapiens 53.61 11.46 3 11 O15511 Actin-related protein 2/3 complex subunit 5 ARPC5 Homo sapiens 53.45 20.53 2 11 Q9Y3F4 Serine-threonine kinase receptor-associated STRAP Homo sapiens 49.03 8.86 2 11 protein P49591 Serine-tRNA ligese, cytoplasmic SARS Homo sapiens 48.84 16.54 5 11 P07954 Fumarate hydratase, mitochondrial FH Homo sapiens 48.14 8.63 2 11 Q15008 26S proteasom non-ATPase regulatory PSMD6 Homo sapiens 46.03 7.20 2 11 subunit 6 Q6IAA8 Ragulator complex protein LAMTOR1 LAMTOR1 Homo sapiens 45.57 15.53 2 11 P23246 Splicing factor, proline- and glutamine-rich SFPQ Homo sapiens 44.03 6.93 4 11 Q02618 Nucleobindin-1 NUCB1 Homo sapiens 41.49 6.29 2 11 Q9Y5X1 Sorting nexin-9 SNX9 Homo sapiens 41.27 7.39 3 11 P31937 3-hydroxyisobutyrate dehydrogenase, HIBADH Homo sapiens 40.12 7.14 2 11 mitochondrial Q99632 T-complex protein 1 subunit eta CCT7 Homo sapiens 39.69 11.97 4 11 P22087 rRNA 2-O-methyltransferase fibrillarin FBL Homo sapiens 38.41 12.15 3 11 Q9NR31 GTP-binding protein SAR1a SAR1A Homo sapiens 37.09 21.72 3 11 P43487 Ran-specific GTPase-activating protein RANBP1 Homo sapiens 36.66 16.92 2 11 Q8IZP2 Putative protein FAM10A4 ST13P4 Homo sapiens 36.63 17.08 3 11 P51858 Hepatoma-derived growth factor HDGF Homo sapiens 36.37 13.75 2 11 Q13263 Transcription intermediary factor 1-beta TRIM28 Homo sapiens 35.01 5.87 3 11 O60282 Kinesin heavy chain isoform 5C KIF5C Homo sapiens 34.89 2.51 2 11 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 ERAP1 Homo sapiens 33.59 5.84 4 11 Q13561 Dynactin subunit 2 DCTN2 Homo sapiens 33.10 8.23 2 11 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 Homo sapiens 32.68 6.03 3 11 P00403 Cytochrome c oxidase subunit 2 MT-CO2 Homo sapiens 31.76 20.26 3 11 Q15417 Calponin-3 CNN3 Homo sapiens 29.35 7.60 2 11 P14406 Cytochrome C oxidase subunit 7A2, COX7A2 Homo sapiens 28.49 27.71 2 11 mitochondrial P28799 Granulins GRN Homo sapiens 48.40 8.43 2 10 P28331 NADH-ubiquinone oxidoreductase 75 kDa NDUFS1 Homo sapiens 48.36 7.84 3 10 subunit, mitochondrial Q92597 Protein NDRG1 NDRG1 Homo sapiens 44.52 8.88 2 10 P48643 T-complex protein 1 subunit epsilon CCT5 Homo sapiens 44.52 12.20 4 10 P00568 Adenylate kinase isoenzyme 1 AK1 Homo sapiens 44.50 25.77 4 10 O00410 Importin-5 IPO5 Homo sapiens 44.31 5.10 3 10 P04216 Thy-1 membrane glycoprotein THY1 Homo sapiens 42.19 15.53 2 10 P62191 26S protease regulatory subunit 4 PSMC1 Homo sapiens 41.71 8.18 2 10 P61916 Epididymal secretory protein E1 NPC2 Homo sapiens 41.08 25.83 2 10 Q53GQ0 Estradiol 17-beta-dehydrogenase 12 HSD17B12 Homo sapiens 40.53 14.10 3 10 P09429 High mobility group protein B1 HMGB1 Homo sapiens 38.34 21.86 3 10 Q9NTK5 Obg-like ATPase 1 OLA1 Homo sapiens 38.07 11.11 3 10 Q96CW1 AP-2 complex subunit mu AP2M1 Homo sapiens 36.90 15.17 4 10 P99999 Cytochrome c CYCS Homo sapiens 36.48 24.76 2 10 P22102 Trifunctional purine biosynthetic protein GART Homo sapiens 35.51 2.67 2 10 adenosine-3 [Includes: Phosphoribosylamine-- glycine ligase] P38117 Electron transfer flavoprotein subunit beta ETFB Homo sapiens 35.36 10.20 2 10 P10253 Lysosomal alpha-glucosidase GAA Homo sapiens 34.48 4.94 3 10 P14868 Aspartate--tRNA ligase, cytoplasmic DARS Homo sapiens 34.20 7.78 3 10 P18621 60S ribosomal protein L17 RPL17 Homo sapiens 32.59 17.93 3 10 P46977 Dolichyl-diphosphooligosaccharide-protein STT3A Homo sapiens 32.58 3.69 2 10 glycosyltransferase subunit STT3A P55735 Protein SEC13 homolog SEC13 Homo sapiens 30.57 15.22 3 10 Q9Y646 Carboxypeptidase Q CPQ Homo sapiens 29.57 4.24 2 10 O95747 Serine/threonine-protein kinase OSR1 OXSR1 Homo sapiens 28.78 4.93 2 10 Q16795 NADH dehydrogenase [ubiquinone] 1 alpha NDUFA9 Homo sapiens 28.28 9.28 3 10 subcomplex subunit 9, mitochondrial Q13425 Beta-2-syntrophin SNTB2 Homo sapiens 27.91 3.89 2 10 Q9HC38 Glyoxalase domain-containing protein 4 GLOD4 Homo sapiens 26.47 7.35 2 10 P22307 Non-specifc lipid-transfer protein SCP2 Homo sapiens 25.98 3.47 2 10 P25787 Proteasome subunit alpha type-2 PSMA2 Homo sapiens 41.91 27.78 4 9 Q02952 A-kinase, anchor protein 12 AKAP12 Homo sapiens 41.76 7.58 6 9 P09619 Platelet-derived growth factor receptor beta PDGFRB Homo sapiens 41.28 5.24 3 9 O00154 Cytosolic acyl coenzyme A thioester ACOT7 Homo sapiens 36.65 12.37 3 9 hydrolase O14880 Microsomal glulathione S-transferase 3 MGST3 Homo sapiens 36.64 23.03 2 9 O15143 Actin-related protein 2/3 complex subunit 1B ARPC1B Homo sapiens 36.57 18.55 4 9 O75131 Copine-3 CPNE3 Homo sapiens 34.80 6.33 2 9 P80723 Brain acid soluble protein 1 BASP1 Homo sapiens 33.15 18.94 3 9 Q1KMD3 Heterogeneous nuclear ribonucleoprotein U- HNRNPUL2 Homo sapiens 32.68 4.82 2 9 like protein 2 Q9Y4L1 Hypoxia up-regulated protein 1 HYOU1 Homo sapiens 31.81 6.81 4 9 Q9Y371 Endophilin-B1 SH3GLB1 Homo sapiens 28.93 7.40 2 9 O43615 Mitochondrial import inner membrane TIMM44 Homo sapiens 28.91 5.09 2 9 translocase subunit TIM44 Q9Y3U8 60S ribosomal protein L36 RPL36 Homo sapiens 26.89 21.90 3 9 P35613 Basigin BSG Homo sapiens 26.77 8.31 2 9 O94832 Unconventional myosin-Id MYO1D Homo sapiens 26.14 2.49 2 9 Q9BWM7 Sideroflexin-3 SFXN3 Homo sapiens 26.01 8.62 2 9 P84098 60S ribosomal protein L19 RPL19 Homo sapiens 25.73 13.27 2 9 Q9UM54 Unconventional myosin-VI MYO6 Homo sapiens 25.66 2.16 2 9 P62851 40S ribosomal protein S25 RPS25 Homo sapiens 24.91 16.00 2 9 P27695 DNA-(apurinic or apyrimidinic site) lyase APEX1 Homo sapiens 41.98 29.87 5 8 P30085 UMP-CMP kinase CMPK1 Homo sapiens 37.21 16.84 2 8 P10768 S-formylglulathione hydrolase ESD Homo sapiens 34.83 25.18 4 8 Q9Y224 UPF0568 protein C14orf166 C14ORF166 Homo sapiens 30.19 22.54 4 8 P43490 Nicotinamide phosphoribosyltransferase NAMPT Homo sapiens 29.74 8.35 2 8 P43243 Matrin-3 MATR3 Homo sapiens 28.76 7.20 4 8 P54578 Ubiquitin carboxyl-terminal hydrolase 14 USP14 Homo sapiens 27.29 5.87 2 8 Q9UJ70 N-acetyl-D-glucosamine kinase NAGK Homo sapiens 24.55 17.73 4 8 P52272 Heterogeneous nuclear ribonucleoprotein M HNRNPM Homo sapiens 24.43 4.79 3 8 O95336 6-phosphogluconolactonase PGLS Homo sapiens 24.35 17.05 3 8 P0CW22 40S ribosomal protein S17-like RPS17L Homo sapiens 24.28 39.26 4 8 P27708 CAD protein [Includes: Glutamine-dependent CAD Homo sapiens 22.05 0.90 2 8 carbamoyl-phosphate synthase] Q02543 60S ribosomal protein L18a RPL18A Homo sapiens 19.31 8.52 2 8 P48147 Protyl endopeptidase PREP Homo sapiens 32.74 7.61 3 7 Q9ULZ3 Apoptosis-associated speck-like protein PYCARD Homo sapiens 31.58 20.00 3 7 containing a CARD P09936 Ubiqutin carboxyl-terminal hydrolase UCHL1 Homo sapiens 30.85 30.04 4 7 isozyme L1 P28161 Glutathione S-transferase Mu 2 GSTM2 Homo sapiens 28.86 28.90 4 7 O75955 Flotillin-1 FLOT1 Homo sapiens 27.63 11.24 3 7 P53007 Tricarboxylate transport protein, SLC25A1 Homo sapiens 27.37 11.25 3 7 mitochondrial Q02218 2-oxoglutarate dehydrogenase, mitochondrial OGDH Homo sapiens 26.92 7.72 4 7 P23381 Tryptophan--tRNA ligase, cytoplasmic WARS Homo sapiens 25.94 6.16 2 7 P19367 Hexokinase-1 HK1 Homo sapiens 25.59 4.14 3 7 Q969H6 UPF0556 protein C19orf10 C19ORF10 Homo sapiens 24.70 15.03 2 7 P07942 Laminin subunit beta-1 LAMB1 Homo sapiens 23.93 2.69 3 7 P06865 Beta-hexosaminidase subunit alpha HEXA Homo sapiens 23.56 7.75 3 7 Q63ZY3 KN motif and ankyrin repeat domain- KANK2 Homo sapiens 22.46 4.70 3 7 containing protein 2 Q9UQ80 Proliferation-associated protein 2G4 PA2G4 Homo sapiens 22.38 13.20 3 7 Q96FQ6 Protein S100-A16 S100A16 Homo sapiens 22.13 22.33 2 7 P67775 Serine/threonine-protein phosphatase 2A PPP2CA Homo sapiens 21.41 15.86 3 7 catalytic subunit alpha isoform P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 Homo sapiens 21.31 5.80 2 7 Q16718 NADH dehydrogenase [ubiquinone] 1 alpha NDUF45 Homo sapiens 20.43 22.41 2 7 subcomplex subunit 5 P10644 cAMP-dependent protein kinase type I-alpha PRKAR1A Homo sapiens 20.35 9.19 2 7 regulatory subunit P55010 Eukaryotic translation initiation factor 5 EIF5 Homo sapiens 20.27 5.57 2 7 P20042 Eukaryotic translation initiation factor 2 EIF2S2 Homo sapiens 20.09 8.11 2 7 subunit 2 P61353 60S ribosomal protein L27 RPL27 Homo sapiens 19.64 21.32 2 7 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 FKBP5 Homo sapiens 19.41 6.58 2 7 O60488 Long-chain-fatty-acid--CoA ligase 4 ACSL4 Homo sapiens 18.27 4.36 2 7 P62913 60S ribosomal protein L11 RPL11 Homo sapiens 17.77 12.92 2 7 P40429 60S ribosomal protein L13a RPL13A Homo sapiens 17.62 8.87 2 7 P43304 Glycerol-3-phosphate dehydrogenase, GPD2 Homo sapiens 31.91 6.05 2 6 mitochondrial P51685 20S proteasome non-ATPase regulatory PSMD7 Homo sapiens 31.27 12.65 2 6 subunit 7 Q16643 Drebrin DBN1 Homo sapiens 29.77 6.32 2 6 P31930 Cytochrome b-c1 complex subunit 1, UQCRC1 Homo sapiens 29.16 8.54 2 6 mitochondrial O43491 Band 4.1-like protein 2 EPB41L2 Homo sapiens 28.75 3.58 2 6 P21281 V-type proton ATPase subunit B, brain ATP6V1B2 Homo sapiens 28.46 6.65 2 6 isoform O00151 PDZ and LIM domain Protein 1 PDLIM1 Homo sapiens 27.03 17.33 3 6 Q08380 Galectin-3-binding protein LGALS3BP Homo sapiens 22.65 7.52 3 6 Q15063 Periostin POSTIN Homo sapiens 22.25 4.31 2 6 P30043 Flavin reductase BLVRB Homo sapiens 21.34 12.14 2 6 P39059 Collagen alpha-1(XV) chain [Cleaved into: COL15A1 Homo sapiens 19.86 2.88 2 6 Restin] Q13126 S-methyl-5-thioadenosine phosphorylase MTAP Homo sapiens 19.56 20.49 3 6 P35871 Phosphoglucomutase-1 PGM1 Homo sapiens 19.51 7.83 3 6 P49821 NADH dehydrogenase [ubiquinone] NDUFV1 Homo sapiens 19.40 7.97 2 6 flavoprotein 1, mitochondrial P13798 Acylamino-acid-releasing enzyme APEH Homo sapiens 19.12 4.78 2 6 P35998 26S protease regulatory subunit 7 PSMC2 Homo sapiens 19.00 5.08 2 6 P48735 Isocitrate dehydrogenase [NADP], IDH2 Homo sapiens 18.47 5.97 2 6 mitodiondrial P42765 3-ketoacyl-CoA thiolase, mitochondrial ACAA2 Homo sapiens 18.27 7.81 2 6 O9Y262 Eukaryotic translation initiation factor 3 EIF3L Homo sapiens 18.24 3.55 2 6 subunit L P10515 Dihydrolipoyllysine-residue acetyltransferase DLAT Homo sapiens 17.45 5.87 3 6 component or pyruvate dehydrogenase complex, mitochondrial P52630 Signal transducer and activator of STAT2 Homo sapiens 17.26 2.82 2 6 transcription 2 Q9Y376 Calcium-binding protein 39 CAB39 Homo sapiens 16.98 6.16 2 6 Q9Y230 RuvB-like 2 RUVBL2 Homo sapiens 16.90 6.21 3 6 Q15758 Neutral amino acid transporter B(0) SLC1A5 Homo sapiens 16.35 4.44 2 6 Q13488 V-type proton ATPase 116 kDa subunit a TCIRG1 Homo sapiens 16.17 2.65 2 6 isoform 3 P67812 Signal peptidase complex catalytic subunit SEC11A Homo sapiens 15.79 9.50 2 6 SEC11A Q9BTV4 Transmembrane protein 43 TMEM43 Homo sapiens 15.70 9.00 2 6 P54819 Adenylate kinase 2, mitochondrial AK2 Homo sapiens 26.93 13.81 2 5 Q08431 Lactadherin MFGE8 Homo sapiens 23.70 8.53 2 5 Q15363 Transmembrane emp24 domain-containing TMED2 Homo sapiens 22.92 13.93 2 5 protein 2 Q99798 Aconitate hydratase, mitochondrial ACO2 Homo sapiens 21.59 7.18 3 5 P47897 Glutamine--tRNA ligase QARS Homo sapiens 20.09 3.74 2 5 Q9BVK6 Transmembrane emp24 domain-containing TMED9 Homo sapiens 19.41 14.47 2 5 protein 9 P49720 Proteasome subunit beta type-3 PSMB3 Homo sapiens 18.74 23.90 3 5 O75947 ATP Synthase subunit d, mitochondrial ATP5H Homo sapiens 18.55 23.60 2 5 Q8NC51 Plasminogen activator inhibitor 1 RNA- SERBP1 Homo sapiens 17.47 12.01 3 5 binding protein Q14247 Src substrate cortactin CTTN Homo sapiens 17.46 4.73 2 5 P56537 Eukaryotic translation initiation factor 6 EIF6 Homo sapiens 16.72 13.88 2 5 P32969 60S ribosomal protein L9 PPL9 Homo sapiens 16.46 15.63 3 5 P53004 Biliverdin reductase A BLVRA Homo sapiens 16.33 10.47 2 5 Q8IVL6 Prolyl 3-hydroxylase 3 LEPREL2 Homo sapiens 16.32 4.21 2 5 Q99961 Endophilin-A2 SH3GL1 Homo sapiens 16.27 12.23 3 5 P34897 Serine hydroxymethyltransferase, SHMT2 Homo sapiens 16.25 4.96 2 5 mitochondrial O75489 NADH dehydrogenase [ubiquinone] iron- NDUFS3 Homo sapiens 15.69 9.09 2 5 sulfur protein 3, mitochondrial P54802 Alpha-N-acetylglucosaminidase NAGLU Homo sapiens 15.09 3.77 2 5 P22105 Tenascin-X TNXB Homo sapiens 14.73 0.44 2 5 P78344 Eukaryotic translation initiation factor 4 EIF4G2 Homo sapiens 14.65 2.32 2 5 gamma 2 Q15392 Delta(24)-sterol reductase DHCR24 Homo sapiens 14.52 5.23 2 5 P11586 C-1-tetrahydrofolete synthase, cytoplasmic MTHFD1 Homo sapiens 14.51 7.49 4 5 P09491 Purine nucleoside phosphorylase PNP Homo sapiens 14.37 9.69 2 5 Q16891 Mitochondrial inner membrane protein IMMT Homo sapiens 13.52 4.35 2 5 Q7L576 Cytoplasmic FMR1-interacting protein 1 CYFIP1 Homo sapiens 13.35 1.84 2 5 O60749 Sorting nexin-2 SNX2 Homo sapiens 13.17 5.97 3 5 Q13510 Acid ceramidase ASAH1 Homo sapiens 23.59 10.13 2 4 Q15942 Zyxin ZYX Homo sapiens 22.85 6.64 2 4 P05198 Eukaryotic translation initation factor 2 EIF2S1 Homo sapiens 19.39 13.65 2 4 subunit 1 P26639 Threonine--tRNA ligase, cytoplasmic TARS Homo sapiens 18.59 7.61 3 4 Q9UL46 Proteasome activator complex subunit 2 PSME2 Homo sapiens 17.60 12.13 2 4 Q9Y2B0 Protein canopy homolog 2 CNPY2 Homo sapiens 16.38 17.03 2 4 Q04837 Single-stranded DNA-binding protein, SSBP1 Homo sapiens 16.36 22.30 2 4 mitochondrial P04040 Catalase CAT Homo sapiens 16.25 6.07 2 4 Q9BQG0 Myb-binding protein 1A MYBBP1A Homo sapiens 14.03 3.92 4 4 P24539 ATP synthase subunit b, mitochondrial ATP5F1 Homo sapiens 13.65 14.84 3 4 Q92896 Golgi apparatus protein 1 GLG1 Homo sapiens 13.63 4.92 3 4 O00764 Pyridoxal kinase PDXK Homo sapiens 12.53 9.29 2 4 P08195 4F2 cell-surface antigen heavy chain SLC3A2 Homo sapiens 12.44 4.13 2 4 P11177 Pyruvate dehydrogenase E1 component PDHB Homo sapiens 12.43 8.91 2 4 subunit beta, mitochondrial P42704 Leucine-rich PPR motif-containing protein, LRPPRC Homo sapiens 12.09 2.44 3 4 mitochondrial Q9NSE4 Isoleucine-tRNA ligase, mitochondrial IARS2 Homo sapiens 12.01 3.16 3 4 Q09028 Histone-binding protein RBBP4 RBBP4 Homo sapiens 11.31 4.94 2 4 Q13641 Trophoblast glycoprotein TPBG Homo sapiens 11.29 6.90 2 4 Q8TED1 Probable glutathione peroxidase 8 GPX8 Homo sapiens 11.12 14.35 2 4 P02533 Keratin, type I cytoskeletal 14 KRT14 Homo sapiens 10.56 5.72 3 4 P63220 40S ribosomal protein S21 RPS21 Homo sapiens 9.98 22.89 2 4 P29966 Myristoylated alanine-rich C-kinase substrate MARCKS Homo sapiens 15.74 19.28 2 3 P13861 cAMP-dependent protein kinase type II-alpha PRKAR2A Homo sapiens 14.72 7.92 2 3 regulatory subunit Q16401 26S proteasome non-ATPase regulatory PSMD5 Homo sapiens 13.99 6.35 2 3 subunit 5 P15848 Arylsulfatase B ARSB Homo sapiens 11.33 4.69 2 3 P60983 Glia maturation factor beta GMFB Homo sapiens 10.95 23.94 2 3 P51648 Fatty aldehyde dehydrogenase ALDH3A2 Homo sapiens 10.57 6.39 2 3 Q92905 COP9 signalosome complex subunit 5 COPS5 Homo sapiens 9.88 6.89 2 3 O00754 Lysosomal alpha-mannosidase MAN2B1 Homo sapiens 9.77 4.06 3 3 P00492 Hypoxanthine-guanine HPRT1 Homo sapiens 9.69 10.55 2 3 phosphoribosyltransferase Q8NBJ5 Procollagen galactosyltransferase 1 COLGALT1 Homo sapiens 9.09 3.70 2 3 P22234 Multifunctional protein ADE2 [Includes: PAICS Homo sapiens 8.98 6.59 2 3 Phosphoribosylaminoimidazole- succinocarboxamide synthase] Q92973 Transportin-1 TNPO1 Homo sapiens 8.69 4.01 2 3 O00263 AP-3 complex subunit beta-1 AP3B1 Homo sapiens 8.64 2.19 2 3 Q13619 Cullin-4A CUL4A Homo sapiens 8.46 3.16 2 3 O14737 Programmed cell death protein 5 PDCD5 Homo sapiens 8.38 17.60 2 3 P61009 Signal peptidase complex subunit 3 SPCS3 Homo sapiens 7.69 12.78 2 3 P24821 Tenascin TNC Homo sapiens 10.38 2.18 2 2 O43504 Ragulator complex protein LAMTOR5 LAMTOR5 Homo sapiens 9.61 43.96 2 2 P58546 Myotrophin MTPN Homo sapiens 8.58 23.73 2 2 O43809 Cleavage and polyadenylation specificity NUDT21 Homo sapiens 7.44 14.54 2 2 factor subunit 5 Q9Y240 C-type lectin domain family 11 member A CLEC11A Homo sapiens 7.24 8.98 2 2 P15289 Arylsulfatase A ARSA Homo sapiens 6.60 6.11 2 2 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 PRPF8 Homo sapiens 5.80 1.24 2 2 Engineered VF mucosa P02454 Collagen alpha-1(I) chain COL1A1 Rattus norvegicus 17939.13 67.17 76 23308 P02452 Collagen alpha-1(I) chain COL1A1 Homo sapiens 9692.90 59.90 58 12942 P02466 Collagen alpha-2(I) chain COL1A2 Rattus norvegicus 12133.22 66.84 65 11242 P08123 Collagen alpha-2(I) chain COL1A2 Homo sapiens 3559.41 53.00 41 3375 Q09666 Neuroblast differentiation-associated protein AHNAK Homo sapiens 4681.98 48.56 130 1337 AHNAK P02461 Collagen alpha-1(III) chain COL3A1 Homo sapiens 1086.61 25.24 23 1275 P12111 Collagen alpha-3(VI) chain COL6A3 Homo sapiens 3130.59 32.61 82 922 P12109 Collagen alpha-1(VI) chain COL6A1 Homo sapiens 1617.48 36.74 22 761 P02751 Fibronectin FN1 Homo sapiens 2824.49 38.14 62 711 P08670 Vimentin VIM Homo sapiens 2203.33 54.72 32 629 P21333 Filamin-A FLNA Homo sapiens 2379.16 38.12 65 583 Q15149 Plectin PLEC Homo sapiens 1740.04 24.12 79 495 P35579 Myosin-9 MYH9 Homo sapiens 2004.50 38.72 58 485 P02545 Prelamin-A/C [Cleaved into: Lamin-A/C] LMNA Homo sapiens 1569.62 56.78 36 449 P60711 Actin, cytoplasmic 1 ACTB Rattus norvegicus 1773.20 63.20 16 446 P14618 Pyruvate kinase PKM PKM Homo sapiens 1609.00 59.70 26 406 P07437 Tubulin beta chain TUBB Homo sapiens 1561.07 68.92 22 406 P07355 Annexin A2 ANXA2 Homo sapiens 1571.61 61.95 21 399 P68371 Tubulin beta-4B chain TUBB4B Homo sapiens 1482.06 72.58 23 382 P04406 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Homo sapiens 1281.24 48.36 14 338 P15144 Aminopeptidase N ANPEP Homo sapiens 1205.90 25.44 24 325 Q13885 Tubulin beta-2A chain TUBB2A Homo sapiens 1196.37 65.17 21 319 Q00610 Clathrin heavy chain 1 CLTC Homo sapiens 1321.28 26.81 34 315 P11021 78 kDa glucose-regulated protein HSPA5 Homo sapiens 1056.41 37.31 20 293 P02458 Collagen alpha-1(II) chain COL2A1 Homo sapiens 434.49 5.65 4 291 Q13509 Tubulin beta-3 chain TUBB3 Homo sapiens 964.94 40.67 15 286 P68104 Elongation factor 1-alpha 1 EEF1A1 Homo sapiens 1185.32 34.20 11 285 O43707 Alpha-actinin-4 ACTN4 Homo sapiens 1087.17 46.65 32 284 P12814 Alpha-actinin-1 ACTN1 Homo sapiens 1005.57 37.33 26 274 P13941 Collagen alpha-1(III) chain COL3A1 Rattus norvegicus 328.06 11.69 10 273 P68363 Tubulin alpha-1B chain TUBA1B Homo sapiens 936.85 47.01 16 269 P12110 Collagen alpha-2(VI) chain COL6A2 Homo sapiens 749.27 28.46 21 268 P00558 Phosphoglycerate kinase 1 PGK1 Homo sapiens 1079.13 52.04 17 265 P11142 Heat shock cognate 71 kDa protein HSPA8 Homo sapiens 954.88 39.94 21 246 P08238 Heat shock protein HSP 90-beta HSP90AB1 Homo sapiens 895.47 33.01 18 234 P06576 ATP synthase subunit beta, mitochondrial ATP5B Homo sapiens 847.43 42.72 15 232 Q9Y490 Talin-1 TLN1 Homo sapiens 941.93 18.30 27 229 P68035 Actin, alpha cardiac muscle 1 ACTC1 Rattus norvegicus 734.75 40.85 11 226 P08758 Annexin A5 ANXA5 Homo sapiens 788.33 67.19 18 213 P50454 Serpin H1 SERPINH1 Homo sapiens 914.27 43.78 14 210 P06733 Alpha-enolase ENO1 Homo sapiens 747.38 48.85 16 209 P04083 Annexin A1 ANXA1 Homo sapiens 841.45 50.00 15 206 P07900 Heat shock protein HSP 90-alpha HSP90AA1 Homo sapiens 758.22 22.81 15 204 P14625 Endoplasmin HSP90B1 Homo sapiens 738.44 30.88 20 202 P08133 Annexin A6 ANXA6 Homo sapiens 735.45 43.54 22 195 P60174 Triosephosphate isomerase TPI1 Homo sapiens 760.58 66.08 14 190 Q14764 Major vault protein MVP Homo sapiens 622.39 32.03 20 180 Q04828 Aldo-keto reductase family 1 member C1 AKR1C1 Homo sapiens 706.40 43.96 12 178 Q9BUF5 Tubulin beta-6 chain TUBB6 Homo sapiens 606.14 38.79 14 178 P04075 Fructose-bisphosphate aldolase A ALDOA Homo sapiens 754.78 60.99 15 176 P46940 Ras GTPase-activating-like protein IQGAP1 IQGAP1 Homo sapiens 687.20 19.79 23 175 P04264 Keratin, type II cytosketal 1 KRT1 Homo sapiens 612.98 36.34 24 173 P13639 Elongation factor 2 EEF2 Homo sapiens 541.61 29.95 23 169 P06396 Gelsolin GSN Homo sapiens 729.67 24.68 14 165 P35555 Fibrilin-1 FBN1 Homo sapiens 596.23 17.24 30 164 Q16555 Dihydropyrimidinase-related protein 2 DPYSL2 Homo sapiens 640.36 41.96 15 159 Q9NZN4 EH domain-containing protein 2 EHD2 Homo sapiens 632.37 38.31 16 159 Q14315 Filamin-C FLNC Homo sapiens 690.18 10.94 17 158 O60814 histone H2B type 1-K HIST1H2BK Homo sapiens 439.34 28.57 3 157 P62937 Peptidyl-prolyl cis-trans isomerase A PPIA Homo sapiens 553.28 55.76 9 156 P29401 Transketolase TKT Homo sapiens 648.74 33.71 15 155 P18669 Phosphoglycerate mutase 1 PGAM1 Homo sapiens 546.57 45.28 10 149 P00338 L-lactate dehydrogenase A chain LDHA Homo sapiens 503.58 37.95 11 147 O43852 Calumenin CALU Homo sapiens 598.11 42.54 13 146 P07237 Protein disulfide-isomerase P4HB Homo sapiens 552.43 38.58 17 144 Q13813 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Homo sapiens 514.56 13.55 22 134 P11413 Glucose-6-phosphate 1-dehydrogenase G6PD Homo sapiens 503.50 36.89 13 134 P18206 Vinculin VCL Homo sapiens 461.06 28.22 22 134 P30101 Protein disulfide-isomerase A3 PDIA3 Homo sapiens 465.94 37.23 15 132 P07585 Decorin DCN Homo sapiens 444.03 43.18 12 130 P55072 Transitional endoplasmic reticulum ATPase VCP Homo sapiens 506.92 32.13 18 129 P11216 Glycogen phosphorylase, brain form PYGB Homo sapiens 485.45 28.47 19 127 Q07065 Cytoskeleton-associated protein 4 CKAP4 Homo sapiens 472.22 41.86 20 127 P27348 14-3-3 protein theta YWHAQ Homo sapiens 444.22 42.45 9 127 P62260 14-3-3 protein epsilon YWHAE Rattus norvegicus 375.64 40.00 8 124 P63104 14-3-3 protein zeta/delta YWHAZ Homo sapiens 432.53 41.22 8 120 Q06830 Peroxiredoxin-1 PRDX1 Homo sapiens 480.66 60.30 10 119 P09382 Galectin-1 LGALS1 Homo sapiens 434.09 46.67 5 119 P16152 Carbonyl reductase [NADPH] 1 CBR1 Homo sapiens 478.30 52.35 10 118 P67936 Tropomyosin alpha-4 chain TPM4 Homo sapiens 419.41 48.79 14 118 O00299 Chloride intracellular channel protein 1 CLIC1 Homo sapiens 454.50 60.17 10 116 P62805 Histone H4 HIST1H4A Homo sapiens 407.94 52.43 7 116 Q14204 Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Homo sapiens 395.38 7.68 26 113 P07195 L-lactate dehydrogenase B chain LDHB Homo sapiens 366.01 37.72 12 113 P27797 Calreticulin CALR Homo sapiens 468.52 37.41 9 111 P13489 Ribonuclease inhibitor RNH1 Homo sapiens 451.04 40.35 12 111 Q99536 Synaptic vesicle membrane protein VAT-1 VAT1 Homo sapiens 425.08 32.06 8 106 homolog P63244 Guanine nucleotide-binding protein subunit GNB2L1 Homo sapiens 387.23 58.68 12 104 beta-2-like 1 Q01082 Spectrin beta chain, non-erythrocytic 1 SPTBN1 Homo sapiens 384.44 12.10 20 104 P22314 Ubiquitin-like modifier-activating enzyme 1 UBA1 Homo sapiens 382.34 23.72 16 104 P10809 60 kDa heat shock protein, mitochondrial HSPD1 Homo sapiens 394.59 27.05 12 103 P23264 Peptidyl-prolyl cis-trans isomerase B PPIB Homo sapiens 334.48 36.57 8 103 Q03135 Caveolin-1 CAV1 Homo sapiens 373.84 63.48 9 102 P09211 Glutathione S-transferase P GSTP1 Homo sapiens 429.56 53.33 8 101 O60664 Perilipin-3 PLIN3 Homo sapiens 386.15 37.79 10 101 P53396 ATP-citrate synthase ACLY Homo sapiens 383.16 17.80 13 101 P08107 Heat shock 70 kDa protein 1A/1B HSPA1A Homo sapiens 357.20 28.71 14 101 P42330 Aldo-keto reductase family 1 member C3 AKR1C3 Homo sapiens 412.36 35.60 9 99 P25705 ATP synthase subunit alpha, mitochondrial ATP5A1 Homo sapiens 390.18 22.24 9 98 P23528 Cofilin-1 CFL1 Homo sapiens 402.40 57.23 9 97 Q6NZI2 Polymerase I and transcript release factor PTRF Homo sapiens 370.34 25.84 9 96 Q9NZM1 Myoferlin MYOF Homo sapiens 359.24 14.65 20 96 P07602 Proactivator polypeptide [Cleaved into: PSAP Homo sapiens 229.01 20.23 10 96 Saposin-A] P40926 Malate dehydrogenase, mitochondrial MDH2 Homo sapiens 368.82 42.31 10 95 P36955 Pigment epithelium-derived factor SERPINF1 Homo sapiens 342.17 25.84 10 95 P35556 Fibrilin-2 FBN2 Homo sapiens 354.09 7.14 14 92 P38646 Stress-70 protein, mitochondrial HSPA9 Homo sapiens 350.09 21.06 10 91 P40939 Trifunctional enzyme subunit alpha, HADHA Homo sapiens 366.81 17.17 8 90 mitochondrial P51884 Lumican LUM Homo sapiens 301.46 29.29 8 90 P21980 Protein-glutamine gamma-glutamyltransferase TGM2 Homo sapiens 335.23 20.96 10 89 P49368 T-complex protein 1 subunit gamma CCT3 Homo sapiens 331.43 29.17 11 89 P05388 60S acidic ribosomal protein P0 RPLP0 Homo sapiens 366.21 37.85 8 88 P37802 Transgelin-2 TAGLN2 Homo sapiens 348.12 46.73 8 88 P51149 Ras-related protein Rab-7a RAB7A Homo sapiens 315.29 42.51 7 88 Q15019 Septin-2 41884 Homo sapiens 343.22 42.66 9 86 Q96AY3 Peptidyl-prolyl cis-trans isomerase FKBP-10 FKBP10 Homo sapiens 287.19 20.79 9 85 P26038 Moesin MSN Homo sapiens 334.03 23.22 13 84 P27824 Calnexin CANX Homo sapiens 327.37 19.26 9 84 P06744 Glucose-6-phosphate isomerase GPI Homo sapiens 340.63 27.78 9 83 P61978 Heterogeneous nuclear ribonucleoprotein K HNRNPK Homo sapiens 314.43 29.59 10 83 P11766 Alcohol dehydrogenase class-3 ADH5 Homo sapiens 385.13 22.99 6 82 P49327 Fatty acid synthase FASN Homo sapiens 344.44 10.51 16 82 P21796 Voltage-dependent anion-selective channel VDAC1 Homo sapiens 326.64 27.21 6 82 protein 1 P30041 Peroxiredoxin-6 PRDX6 Homo sapiens 299.10 44.64 8 82 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 CAND1 Homo sapiens 279.60 11.30 10 82 P60660 Myosin light polypeptide 5 MYL6 Homo sapiens 263.81 48.34 7 82 P09525 Annexin A4 ANXA4 Homo sapiens 276.12 35.11 9 81 P53618 Coatomer subunit beta COPB1 Homo sapiens 240.03 17.00 11 77 P98095 Fibulin-2 FBLN2 Homo sapiens 297.15 17.15 13 76 P07858 Cathepsin B CTSB Homo sapiens 325.77 28.02 7 75 P05387 60S acidic ribosomal protein P2 RPLP2 Homo sapiens 312.25 76.52 5 75 P31946 14-3-3 protein beta/alpha YWHAB Homo sapiens 256.23 32.52 6 74 P61981 14-3-3 protein gamma YWHAG Homo sapiens 253.62 20.65 4 74 P07686 Beta-hexosaminidase subunit beta HEXB Homo sapiens 223.90 11.69 5 74 O75083 WD repeat-containing protein 1 WDR1 Homo sapiens 403.80 26.24 8 73 Q04446 1,4-alpha-glucan-branching enzyme GBE1 Homo sapiens 322.94 20.66 9 73 P45880 Voltage-dependent anion-selective channel VDAC2 Homo sapiens 262.24 25.85 5 73 protein 2 P04844 Dolichyl-diphosphooligosaccharide--protein RPN2 Homo sapiens 295.08 28.68 11 72 glycosyltransferase subunit 2 P08865 40S ribosomal protein SA RPSA Homo sapiens 285.15 36.95 8 72 P00387 NADH-cytochrome b5 reductase 3 CYB5R3 Homo sapiens 280.81 31.56 7 71 P78527 DNA-dependent protein kinase catalytic PRKDC Homo sapiens 267.13 5.77 15 71 subunit P02792 Ferritn light chain FTL Homo sapiens 323.33 36.00 5 70 P52209 6-phosphogluconate dehydrogenase, PGD Homo sapiens 281.42 18.22 6 70 decarboxylating P02768 Serum albumin ALB Homo sapiens 281.23 3.94 3 70 P09972 Fructose-bisphosphate aldolase C ALDOC Homo sapiens 303.97 22.53 5 69 Q07954 Prolow-density lipoproten receptor-related LRP1 Homo sapiens 255.24 5.02 16 69 protein 1 P07339 Cathepsin D CTSD Homo sapiens 246.82 20.63 6 69 Q15582 Transforming growth factor-beta-induced TGFBI Homo sapiens 219.77 10.54 6 69 protein ig-h3 P07737 Profilin-1 PFN1 Homo sapiens 216.88 64.29 8 69 Q9Y678 Coatomer subunit gamma-1 COPG1 Homo sapiens 274.16 10.41 6 68 P26641 Elongation factor 1-gamma EEF1G Homo sapiens 269.96 24.49 8 68 Q96AG4 Leucine-rich repeat-containing protein 59 LRRC59 Homo sapiens 259.13 31.60 6 68 P61158 Actin-related protein 3 ACTR3 Homo sapiens 296.73 27.75 8 67 Q15084 Protein disulfide-isomerase A6 PDIA6 Homo sapiens 252.32 32.50 9 67 P50995 Annexin A11 ANXA11 Homo sapiens 233.06 12.87 5 67 P62241 40S ribosomal protein S8 RPS8 Homo sapiens 227.53 31.73 5 67 Q9H299 SH3 domain-binding glutamic acid-rich-like SH3BGRL3 Homo sapiens 248.90 31.18 3 66 protein 3 P19105 Myosin regulatory light chain 12A MYL12A Homo sapiens 243.16 39.18 5 66 O60701 UDP-glucose 6-dehydrogenase UGDH Homo sapiens 237.32 37.45 14 66 P52907 F-actin-capping protein subunit alpha-1 CAPZA1 Homo sapiens 256.92 41.26 7 65 Q9NQC3 Reticulon-4 RTN4 Homo sapiens 252.94 9.65 6 65 P40925 Malate dehydrogenase, cytoplasmic MDH1 Homo sapiens 225.55 24.55 6 65 Q15365 Poly(rC)-binding protein 1 PCBP1 Homo sapiens 225.32 32.02 6 65 P22626 Heterogeneous nuclear ribonucleoproteins HNRNPA2B1 Homo sapiens 223.70 30.88 9 65 A2/B1 P12236 ADP/ATP translocase 3 SLC25A6 Homo sapiens 178.86 28.52 8 65 Q14697 Neutral alpha-glucosidase AB GANAB Homo sapiens 308.38 13.67 9 64 P60842 Eukaryotic initiation factor 4A-I EIF4A1 Homo sapiens 212.29 21.67 7 63 Q96D15 Reticulocalbin-3 RCN3 Homo sapiens 267.03 27.13 5 62 P30086 Phosphatidylethanolamine-binding protein 1 PEBP1 Homo sapiens 260.87 56.15 6 62 Q01518 Adenylyl cyclase-associated protein 1 CAP1 Homo sapiens 227.58 23.79 9 62 Q14974 Importin subunit beta-1 KPNB1 Homo sapiens 227.02 17.01 10 62 P55786 Puromycin-sensitive aminopeptidase NPEPPS Homo sapiens 202.84 13.93 10 62 P17655 Calpain-2 catalytic subunit CAPN2 Homo sapiens 230.99 17.43 7 61 P04792 Heat shock protein beta-1 HSPB1 Homo sapiens 221.22 40.00 7 61 Q92928 Putative Ras-related protein Rab-1C RAB1C Homo sapiens 189.19 31.34 5 61 P23396 40S nibosomal protein S3 RPS3 Homo sapiens 182.60 52.26 10 61 P04843 Dolichyl-diphosphooligosaccharide--protein RPN1 Homo sapiens 231.88 17.96 7 60 glycosyltransferase subunit 1 P15121 Aldose reductase AKR1B1 Homo sapiens 225.73 33.86 6 60 Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU Homo sapiens 224.96 15.03 7 60 P35237 Serpin B6 SERPINB6 Homo sapiens 208.98 23.67 7 60 Q969G5 Protein kinase C delta-binding protein PRKCDBP Homo sapiens 200.31 31.03 7 60 P36578 60S ribosomal protein L4 RPL4 Homo sapiens 196.11 19.20 7 60 P17301 Integrin alpha-2 ITGA2 Homo sapiens 231.23 14.31 11 59 P00367 Glutamate dehydrogenase 1, mitochondrial GLUD1 Homo sapiens 221.30 20.43 8 59 O00159 Unconventional myosin-Ic MYO1C Homo sapiens 204.23 15.71 12 59 P12956 X-ray repair cross-complementing protein 6 XRCC6 Homo sapiens 190.12 20.53 10 58 Q16658 Fascin FSCN1 Homo sapiens 227.09 20.08 8 57 P22392 Nucleoside diphosphate kinase B NME2 Homo sapiens 196.95 40.13 5 57 Q96CX2 BTB/POZ domain-containing protein KCTD12 KCTD12 Homo sapiens 173.33 14.77 4 57 P05141 ADP/ATP translocase 2 SLC25A5 Homo sapiens 157.41 25.17 7 57 P35527 Keratin, type I cytoskeletal 9 KRT9 Homo sapiens 274.80 30.82 12 56 Q8IUX7 Adipocyte enhancer-binding protein 1 AEBP1 Homo sapiens 245.03 10.71 8 56 P50990 T-complex protein 1 subunit theta CCT8 Homo sapiens 199.96 19.16 8 56 P18085 ADP-ribosylation factor 4 ARF4 Homo sapiens 173.35 48.89 8 56 P02794 Ferritin heavy chain FTH1 Homo sapiens 271.23 46.45 8 55 Q9Y696 Chloride intracellular channel protein 4 CLIC4 Homo sapiens 221.19 54.15 8 55 P49748 Very long-chain specific acyl-CoA ACADVL Homo sapiens 219.10 20.00 9 55 dehydrogenase, mitochondrial P98160 Basement membrane-specific heparan sulfate HSPG2 Homo sapiens 208.59 5.01 14 55 proteoglycan core protein Q14108 Lysosome membrane protein 2 SCARB2 Homo sapiens 194.36 19.46 6 55 P62424 60S ribosomal protein L7a RPL7A Homo sapiens 182.21 29.70 7 55 P63241 Eukaryotic translation initiation factor 5A-1 EIF5A Homo sapiens 232.00 30.52 5 54 P07108 Acyl-CoA-binding protein DBI Homo sapiens 224.72 50.57 3 54 P30153 Serine/threonine-protein phosphatase 2A 65 kDa PPP2R1A Homo sapiens 217.26 19.02 7 54 regulatory subunit A alpha isoform P30050 60S ribosomal protein L12 RPL12 Homo sapiens 198.47 54.55 6 54 P16278 Beta-galactosidase GLB1 Homo sapiens 198.03 11.23 6 54 P53621 Coatomer subunit alpha COPA Homo sapiens 169.83 10.78 10 54 P60033 CD81 antigen CD81 Homo sapiens 252.20 25.00 3 53 P21810 Biglycan BGN Homo sapiens 223.44 24.73 8 53 P13667 Protein disulfide-isomerase A4 PDIA4 Homo sapiens 220.61 16.90 7 53 Q96KK5 Histone H2A type 1-H HIST1H2AH Homo sapiens 188.17 27.34 3 53 P37837 Transaldolase TALDO1 Homo sapiens 169.53 14.24 4 53 P52565 Rho GDP-dissociation inhibitor 1 ARHGDIA Homo sapiens 191.81 21.08 4 52 Q9P2E9 Ribosome-binding protein 1 RRBP1 Homo sapiens 182.04 11.63 10 52 P61204 ADP-ribosylation factor 3 ARF3 Homo sapiens 175.59 38.67 6 52 P68871 Hemoglobin subunit beta HBB Homo sapiens 167.11 53.74 6 52 Q99497 Protein DJ-1 PARK7 Homo sapiens 200.89 29.63 4 51 P21589 5-nucleotidase NT5E Homo sapiens 178.39 26.31 11 51 P46821 Microtubule-associated protein 1B MAP1B Homo sapiens 172.54 8.35 13 51 Q15293 Reticulocalbin-1 RCN1 Homo sapiens 204.33 29.91 6 50 P07910 Heterogeneous nuclear ribonucleoproteins HNRNPC Homo sapiens 147.42 18.30 5 50 C1/C2 P09651 Heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 Homo sapiens 178.69 22.58 6 49 Q99715 Collagen alpha-1(XII) chain COL12A1 Homo sapiens 178.41 5.91 12 49 P61247 40S ribosomal protein S3a RPS3A Homo sapiens 175.98 18.18 4 49 P10599 Thioredoxin TXN Homo sapiens 159.77 42.86 5 49 Q9Y6N5 Sulfide: quinone oxidoreductase, mitochondrial SQRDL Homo sapiens 168.71 28.00 10 48 P50395 Rab GDP dissociation inhibitor beta GDI2 Homo sapiens 180.18 27.64 9 47 O43390 Heterogeneous nuclear ribonucleoprotein R HNRNPR Homo sapiens 178.95 8.53 4 47 Q01813 6-phosphofructokinase type C PFKP Homo sapiens 178.62 9.31 5 47 P07384 Calpain-1 catalytic subunit CAPN1 Homo sapiens 157.93 12.61 6 47 P55209 Nucleosome assembly protein 1-like 1 NAP1L1 Homo sapiens 188.64 17.14 5 46 P47755 F-actin-capping protein subunit alpha-2 CAPZA2 Homo sapiens 173.61 28.67 6 46 P14550 Alcohol dehydrogenase [NADP(+)] AKR1A1 Homo sapiens 169.26 13.54 4 46 P50609 Fibromodulin FMOD Rattus norvegicus 162.36 14.10 4 46 P24534 Elongation factor 1-beta EEF1B2 Homo sapiens 195.28 20.44 3 45 P04080 Cystatin-B CSTB Homo sapiens 183.06 45.92 3 45 P14314 Glucosidase 2 subunit beta PRKCSH Homo sapiens 171.16 9.85 4 45 P46782 40S ribosomal protein S5 [Cleaved into: 40S RPS5 Homo sapiens 157.22 18.14 3 45 ribosomal protein S5, N-terminally processed] P22105 Tenascin-X TNXB Homo sapiens 152.49 5.99 10 45 Q07020 60S ribosomal protein L18 RPL18 Homo sapiens 146.31 30.85 5 45 P50991 T-complex protein 1 subunit delta CCT4 Homo sapiens 186.69 8.53 3 44 P62158 Calmodulin CALM1 Homo sapiens 185.02 29.53 3 44 O95782 AP-2 complex subunit alpha-1 AP2A1 Homo sapiens 159.92 9.52 7 44 P17980 26S protease regulatory subunit 6A PSMC3 Homo sapiens 155.58 29.61 8 44 P30044 Peroxiredoxin-5, mitochondrial PRDX5 Homo sapiens 142.09 34.11 5 44 P48444 Coalomer subunit delta ARCN1 Homo sapiens 128.85 9.00 4 44 P16403 Histone H1.2 HIST1H1C Homo sapiens 127.74 15.49 4 44 P23219 Prostaglandin G/H synthase 1 PTGS1 Homo sapiens 174.36 12.85 5 43 P62826 GTP-binding nuclear protein Ran RAN Homo sapiens 156.07 39.35 7 43 P34932 Heat shock 70 kDa protein 4 HSPA4 Homo sapiens 142.63 12.88 7 43 P13645 Keratin, type I cytoskeletal 10 KRT10 Homo sapiens 134.26 20.03 9 43 P55084 Trifunctional enzyme subunit beta, HADHB Homo sapiens 160.26 19.20 7 42 mitochondrial P04899 Guanine nucleotide-binding protein G(i) GNAI2 Homo sapiens 149.06 17.18 4 42 subunit alpha-2 P11047 Laminin subunit gamma-1 LAMC1 Homo sapiens 141.74 6.53 7 42 P12882 Myosin-1 MYH1 Homo sapiens. 159.40 5.98 8 41 P62701 40S ribosomal protein S4, X isoform RPS4X Homo sapiens 146.21 29.66 7 41 P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNP43 Homo sapiens 140.08 17.20 5 41 Q15366 Poly(rC)-binding protein 2 PCBP2 Homo sapiens 126.95 14.79 4 41 P50914 60S ribosomal protein L14 RPL14 Homo sapiens 118.43 20.93 4 41 P05386 60S acidic ribosomal protein P1 RPLP1 Homo sapiens 214.61 51.75 2 40 P62906 60S ribosomal protein L10a RPL10A Homo sapiens 160.47 25.81 4 40 P10909 Clusterin CLU Homo sapiens 142.36 13.81 4 40 P15531 Nucleoside diphosphate kinase A NME1 Homo sapiens 140.96 39.47 5 40 P27105 Erythrocyte band 7 integral membrane protein STOM Homo sapiens 138.94 24.65 5 40 Q12797 Aspartyl/asparaginyl bela-hydroxylase ASPH Homo sapiens 138.22 10.55 5 40 P32119 Peroxiredoxin-2 PRDX2 Homo sapiens 137.82 19.70 4 40 P39687 Acidic leucine-rich nuclear phosphoprotein 32 ANP32A Homo sapiens 133.72 12.85 3 40 family member A P05556 Integrin beta-1 ITGB1 Homo sapiens 128.26 12.28 8 40 P27816 Microtubule-associated protein 4 MAP4 Homo sapiens 122.94 9.90 8 40 Q9Y6C2 EMILIN-1 EMILIN1 Homo sapiens 140.17 9.45 6 39 P08134 Rho-related GTP-binding protein RhoC RHOC Homo sapiens 138.88 32.64 5 39 P62979 Ubiquitin-40S ribosomal protein S27a RPS27A Homo sapiens 138.38 33.97 4 39 P19338 Nucleolin NCL Homo sapiens 136.47 13.66 8 39 P78371 T-complex protein 1 subunit beta CCT2 Homo sapiens 160.95 27.29 10 38 P69905 Hemoglobin subunit alpha HBA1 Homo sapiens 143.65 48.59 4 38 P62277 40S ribosomal protein S13 RPS13 Homo sapiens 139.22 18.54 3 38 P17931 Galectin-3 LGALS3 Homo sapiens 137.26 28.40 6 38 P61586 Transforming protein RhoA RHOA Homo sapiens 134.81 38.86 6 38 Q13838 Spliceosome RNA helicase DDX39B DDX39B Homo sapiens 132.68 22.43 6 38 P41250 Glycine-tRNA ligase GARS Homo sapiens 120.83 10.42 5 38 P31949 Protein S100-A11 S100A11 Homo sapiens 110.54 25.71 3 38 Q16851 UTP-glucose-1-phosphate uridylyltransferase UGP2 Homo sapiens 192.68 10.24 3 37 Q7KZF4 Staphylococcal nuclease domain-containing SND1 Homo sapiens 139.09 13.52 8 37 protein 1 P31939 Bifunctional purine biosynthesis protein PURH ATIC Homo sapiens 136.29 9.97 5 37 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase] P48047 ATP synthase subunit O, mitochondrial ATP5O Homo sapiens 127.11 44.60 6 37 P61106 Ras-related protein Rab-14 RAB14 Homo sapiens 127.06 30.70 4 37 O75874 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 Homo sapiens 121.13 21.01 6 37 O43776 Asparagine-tRNA ligase, cytoplasmic NARS Homo sapiens 119.15 18.43 8 37 P56134 ATP synthase subunit f, mitochondrial ATP5J2 Homo sapiens 117.20 25.53 2 37 P62249 40S ribosomal protein S16 RPS16 Homo sapiens 108.15 22.60 3 37 Q8NBS9 Thioredoxin domain-containing protein 5 TXNDC5 Homo sapiens 165.47 9.26 3 36 Q12905 Interleukin enhancer-binding factor 2 ILF2 Homo sapiens 139.27 11.28 3 36 Q9UBG0 C-type mannose receptor 2 MRC2 Homo sapiens 134.77 4.87 5 36 P06753 Tropomyosin alpha-3 chain TPM3 Homo sapiens 111.21 13.38 5 36 P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Homo sapiens 158.27 29.63 3 35 Q07021 Complement component 1 Q subcomponent- C1QBP Homo sapiens 157.66 12.06 3 35 binding protein, mitochondrial P26599 Polypyrimidine tract-binding protein 1 PTBP1 Homo sapiens 155.40 14.12 5 35 P49411 Elongation factor Tu, mitochondrial TUFM Homo sapiens 138.71 15.27 4 35 P63010 AP-2 complex subunit beta AP2B1 Homo sapiens 131.57 10.46 7 35 P08253 72 kDa type IV collagenase MMP2 Homo sapiens 125.40 13.64 5 35 P13674 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 Homo sapiens 121.33 14.98 6 35 P35908 Keratin, type II cytoskeletal 2 epidermal KRT2 Homo sapiens 110.24 14.71 8 35 Q13162 Peroxiredoxin-4 PRDX4 Homo sapiens 109.40 16.97 4 35 P00441 Superoxide dismutase [CuZn] SOD1 Homo sapiens 201.61 32.47 4 34 P68036 Ubiquitin-conjugating enzyme E2 L3 UBE2L3 Homo sapiens 166.53 35.71 3 34 P07099 Epoxide hydrolase 1 EPHX1 Homo sapiens 151.01 21.76 7 34 O43399 Tumor protein D54 TPD52L2 Homo sapiens 134.95 31.07 4 34 P23634 Plasma membrane calcium-transporting ATP2B4 Homo sapiens 133.50 3.46 3 34 ATPase 4 P15559 NAD(P)H dehydrogenase [quinone] 1 NQO1 Homo sapiens 125.60 13.50 3 34 P51659 Peroxisomal multifunctional enzyme type 2 HSD17B4 Homo sapiens 122.52 14.67 7 34 P04259 Keratin, type II cytoskeletal 6B KRT6B Homo sapiens 118.21 20.21 10 34 P16615 Sarcoplasmic/endoplasmic reticulum calcium ATP2A2 Homo sapiens 117.26 9.98 8 34 ATPase 2 Q00325 Phosphate carrier protein, mitochondrial SLC25A3 Homo sapiens 115.25 19.06 5 34 P62140 Serine/threonine-protein phosphatase PP1- PPP1CB Homo sapiens 115.19 18.96 5 34 beta catalytic subunit Q96TA1 Niban-like protein 1 FAM129B Homo sapiens 113.43 9.65 5 34 P39019 40S ribosomal protein S19 RPS19 Homo sapiens 109.71 30.34 5 34 P62879 Guanine nucleotide-binding protein GNB2 Homo sapiens 109.17 15.59 5 34 G(I)/G(S)/G(T) subunit beta-2 P29692 Elongation factor 1-delta EEF1D Homo sapiens 108.71 13.17 3 34 P48783 40S ribosomal protein S10 RPS10 Homo sapiens 107.63 14.55 2 34 Q6NXT2 Histone H3.3C H3F3C Homo sapiens 89.79 11.85 2 34 P20810 Calpastatin CAST Homo sapiens 141.21 10.88 4 33 P17858 6-phosphofructokinase, liver type PFKL Homo sapiens 136.89 6.28 3 33 P62888 60S ribosomal protein L30 RPL30 Homo sapiens 131.49 51.30 4 33 Q16698 2,4-dienoyl-CoA reductase, mitochondrial DECR1 Homo sapiens 121.31 13.73 3 33 P15880 40S ribosomal protein S2 RPS2 Homo sapiens 117.17 16.04 4 33 P18124 60S ribosomal protein L7 RPL7 Homo sapiens 116.55 16.13 3 33 P62269 40S ribosomal protein S18 RPS18 Homo sapiens 88.00 16.45 3 33 P16070 CD44 antigen CD44 Homo sapiens 131.22 3.77 2 32 P49755 Transmembrane emp24 domain-containing TMED10 Homo sapiens 124.36 22.37 5 32 protein 10 Q9Y265 RuvB-like 1 RUVBL1 Homo sapiens 113.28 23.03 7 32 P61224 Ras-related protein Rap-1b RAP1B Homo sapiens 104.67 26.09 4 32 Q92688 Acidic leucine-rich nuclear phosphoprotein 32 ANP32B Homo sapiens 103.10 21.12 4 32 family member B Q9BSJ8 Extended synaptotagmin-1 ESYT1 Homo sapiens 102.79 7.61 6 32 P78417 Glutathione S-transferase omega-1 GSTO1 Homo sapiens 95.20 19.92 4 32 P00325 Alcohol dehydrogenase 1B ADH1B Homo sapiens 125.69 20.00 7 31 P62244 40S ribosomal protein S15a RPS15A Homo sapiens 122.31 24.62 3 31 P47756 F-actin-capping protein subunit beta CAPZB Homo sapiens 117.28 20.22 4 31 P42785 Lysosomal Pro-X carboxypeptidase PRCP Homo sapiens 110.84 9.48 3 31 Q14103 Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Homo sapiens 94.78 13.52 4 31 Q01129 Decorin DCN Rattus norvegicus 90.56 11.86 4 31 P14866 Heterogeneous nuclear ribonucleoprotein L HNRNPL Homo sapiens 162.20 13.07 3 30 P06748 Nucleophosmin NPM1 Homo sapiens 125.44 21.77 5 30 O60506 Heterogeneous nuclear ribonucleoprotein Q SYNCRIP Homo sapiens 112.80 14.77 6 30 Q96QK1 Vacuolar protein sorting-associated protein 35 VPS35 Homo sapiens 100.86 9.55 6 30 O00231 26S proteasome non-ATPase regulatory PSMD11 Homo sapiens 95.64 8.77 3 30 subunit 11 O14979 Heterogeneous nuclear ribonucleoprotein D- HNRNPDL Homo sapiens 94.56 9.76 3 30 like Q8WUM4 Programmed cell death 6-interacting protein PDCD6IP Homo sapiens 92.50 5.88 4 30 P59998 Actin-related protein 2/3 complex subunit 4 ARPC4 Homo sapiens 84.05 27.98 5 30 Q9H4M9 EH domain-containing protein 1 EHD1 Homo sapiens 129.70 14.42 5 29 P01033 Metalloproteinase inhibitor 1 TIMP1 Homo sapiens 127.55 22.22 3 29 P28066 Proteasome subunit alpha type-5 PSMA5 Homo sapiens 117.57 35.27 5 29 Q07960 Rho GTPase-activating protein 1 ARHGAP1 Homo sapiens 111.12 14.35 4 29 P02765 Alpha-2-HS-glycoprotein AHSG Homo sapiens 111.09 7.08 4 29 P10155 60 kDa SS-A/Ro ribonucleoprotein TROVE2 Homo sapiens 101.48 4.46 2 29 P21399 Cytoplasmic aconitate hydratase ACO1 Homo sapiens 92.08 9.67 6 29 P83731 60S ribosomal protein L24 RPL24 Homo sapiens 90.95 20.38 3 29 O00571 ATP-dependent RNA helicase DDX3X DDX3X Homo sapiens 90.65 10.12 5 29 P35232 Prohibitin PHB Homo sapiens 85.95 20.96 5 29 P46781 40S ribosomal protein S9 RPS9 Homo sapiens 79.12 25.77 6 29 P62829 60S ribosomal protein L23 RPL23 Homo sapiens 125.59 25.00 2 28 P25398 40S ribosomal protein S12 RPS12 Homo sapiens 123.76 31.82 3 28 Q08211 ATP-dependent RNA helicase A DHX9 Homo sapiens 119.13 4.65 4 28 Q16181 Septin-7 41889 Homo sapiens 111.98 18.76 6 28 P62333 26S protease regulatory subunit 10B PSMC6 Homo sapiens 103.91 14.91 4 28 P13010 X-ray repair cross-complementing protein 5 XRCC5 Homo sapiens 101.49 10.66 5 28 Q13492 Phosphatidylinositol-binding clathrin assembly PICALM Homo sapiens 100.88 4.91 2 28 protein P35606 Coatomer subunit beta COPB2 Homo sapiens 93.08 9.05 6 28 P07996 Thrombospondin-1 THBS1 Homo sapiens 82.64 3.25 3 28 P29373 Cellular retinoic acid-binding protein 2 CRABP2 Homo sapiens 124.05 24.64 3 27 Q00341 Vigilin HDLBP Homo sapiens 109.99 4.89 4 27 P54709 Sodium/potassium-transporting ATPase ATP1B3 Homo sapiens 101.67 17.20 3 27 subunit beta-3 P49257 Protein ERGIC-53 LMAN1 Homo sapiens 98.91 14.51 3 27 Q06323 Proteasome activator complex subunit 1 PSME1 Homo sapiens 95.33 30.52 8 27 P61313 60S ribosomal protein L15 RPL15 Homo sapiens 89.98 12.75 2 27 P35268 60S ribosomal protein L22 RPL22 Homo sapiens 82.39 18.75 2 27 Q96HE7 ERO1-like protein alpha ERO1L Homo sapiens 113.81 13.25 4 26 P28838 Cytosol aminopeptidase LAP3 Homo sapiens 110.86 12.33 4 26 Q9NVA2 Septin-11 41893 Homo sapiens 78.83 8.86 3 26 P20700 Lamin-B1 LMNB1 Homo sapiens 74.71 10.24 6 26 P51636 Caveolin-2 CAV2 Homo sapiens 111.42 29.63 3 25 P60866 40S ribosomal protein S20 RPS20 Homo sapiens 101.62 19.33 2 25 O14818 Proteasome subunit alpha type-7 PSMA7 Homo sapiens 98.96 20.56 3 25 Q9UBI6 Guanine nucleotide-binding protein GNG12 Homo sapiens 97.88 31.94 2 25 G(I)/G(S)/G(O) subunit gamma-12 P13647 Keratin, type II cytoskeletal 5 KRT5 Homo sapiens 86.02 13.90 8 25 O75915 PRA1 family protein 3 ARL6IP5 Homo sapiens 84.77 15.96 2 25 Q9Y2Q3 Glutathione S-transferase kappa 1 GSTK1 Homo sapiens 82.98 28.76 5 25 P62750 60S ribosomal protein L23a RPL23A Homo sapiens 78.51 15.38 2 25 P46776 60S ribosomal protein L27a RPL27A Homo sapiens 74.00 14.19 2 25 Q92743 Serine protease HTRA1 HTRA1 Homo sapiens 73.77 8.75 4 25 P17987 T-complex protein 1 subunit alpha TCP1 Homo sapiens 73.10 6.29 3 25 P30048 Thioredoxin-dependent peroxide reductase, PRDX3 Homo sapiens 121.36 23.44 3 24 mitochondrial P62263 40S ribosomal protein S14 RPS14 Homo sapiens 102.96 27.81 3 24 P07814 Bifunctional glutamate/proline--tRNA ligase EPRS Homo sapiens 96.07 4.30 4 24 P60953 Cell division control protein 42 homolog CDC42 Homo sapiens 91.80 20.42 3 24 P51688 N-sulphoglucosamine sulphohydrolase SGSH Homo sapiens 90.99 8.37 3 24 Q13765 Nascent polypeptide-associated complex NACA Homo sapiens 90.13 12.56 2 24 subunit alpha P01893 Putative HLA class I histocompatibility HLA-H Homo sapiens 89.43 18.23 4 24 antigen, alpha chain H P52272 Heterogeneous nuclear ribonucleoprotein M HNRNPM Homo sapiens 83.38 9.73 5 24 P54920 Alpha-soluble NSF attachment protein NAPA Homo sapiens 81.50 22.37 5 24 P26373 60S ribosomal protein L13 RPL13 Homo sapiens 80.65 10.90 2 24 P26447 Protein S100-A4 S100A4 Homo sapiens 72.92 28.71 4 24 P39060 Collagen alpha-1(XVIII) chain [Cleaved into: COL18A1 Homo sapiens 72.74 3.93 3 24 Endostatin] P78539 Sushi repeat-containing protein SRPX SRPX Homo sapiens 72.54 7.76 3 24 Q9UHD8 Septin-9 41891 Homo sapiens 70.31 10.07 4 24 P46926 Glucosamine-6-phosphate isomerase 1 GNPDA1 Homo sapiens 70.28 14.19 3 24 P61160 Actin-related protein 2 ACTR2 Homo sapiens 70.14 17.26 5 24 Q15185 Prostaglandin E synthase 3 PTGES3 Homo sapiens 117.88 26.25 3 23 O95373 Importin-7 IPO7 Homo sapiens 104.71 4.53 3 23 Q16881 Thioredoxin reductase 1, cytoplasmic TXNRD1 Homo sapiens 90.34 8.17 3 23 P10620 Microsomal glutathione S-tansferase 1 MGST1 Homo sapiens 87.69 27.10 3 23 Q13200 26S proteasome non-ATPase regulatory PSMD2 Homo sapiens 78.79 10.24 6 23 subunit 2 Q9H8H3 Methyltransferase-like protein 7A METTL7A Homo sapiens 77.76 12.30 2 23 P55795 Heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 Homo sapiens 76.64 10.47 3 23 Q05682 Caldesmon CALD1 Homo sapiens 76.04 3.66 3 23 P00966 Argininosuccinate synthase ASS1 Homo sapiens 71.74 10.19 3 23 P51148 Ras-related protein Rab-5C RAB5C Homo sapiens 68.22 23.15 4 23 O75390 Citrate synthase, mitochondrial CS Homo sapiens 67.17 10.09 4 23 Q99829 Copine-1 CPNE1 Homo sapiens 66.73 4.66 2 23 Q92499 ATP-dependent RNA helicase DDX1 DDX1 Homo sapiens 112.53 7.43 3 22 Q08431 Lactadherin MFGE8 Homo sapiens 106.96 8.53 2 22 Q15121 Astrocytic phosphoprotein PEA-15 PEA15 Homo sapiens 105.97 36.92 4 22 Q15181 Inorganic pyrophosphatase PPA1 Homo sapiens 96.51 17.65 4 22 Q99623 Prohibitin-2 PHB2 Homo sapiens 91.02 21.07 5 22 P62280 40S ribosomal protein S11 RPS11 Homo sapiens 89.31 24.68 3 22 P04216 Thy-1 membrane glycoprotein THY1 Homo sapiens 84.64 15.53 2 22 P06703 Protein S100-A6 S100A6 Homo sapiens 84.38 37.78 3 22 P12955 Xaa-Pro dipeptidase PEPD Homo sapiens 80.36 8.32 3 22 Q04760 Lactoylglutathione lyase GLO1 Homo sapiens 70.31 14.67 2 22 Q6NHP8 Putative phospholipase B-like 2 PLBD2 Homo sapiens 69.68 8.49 4 22 P84103 Serine/arginine-rich splicing factor 3 SRSF3 Homo sapiens 69.34 14.02 2 22 P27635 60S ribosomal protein L10 RPL10 Homo sapiens 69.17 11.21 2 22 Q14152 Eukaryotic translation initiation factor 3 subunit A EIF3A Homo sapiens 66.86 5.57 6 22 P61088 Ubiquitin-conjugating enzyme E2 N UBE2N Homo sapiens 63.81 34.87 4 22 P62318 Small nuclear ribonucleoprotein Sm D3 SNRPD3 Homo sapiens 62.37 15.08 2 22 Q99460 26S proteasome non-ATPase regulatory PSMD1 Homo sapiens 120.05 6.72 4 21 subunit 1 P23142 Fibulin-1 FBLN1 Homo sapiens 84.86 13.23 4 21 P68402 Platelet-activating factor acetylhydrolase IB PAFAH1B2 Homo sapiens 83.14 12.23 2 21 subunit beta P10619 Lysosomal protective protein CTSA Homo sapiens 82.10 5.00 2 21 P31943 Heterogeneous nuclear ribouncleoprotein H HNRNPH1 Homo sapiens 80.87 7.57 2 21 P24752 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Homo sapiens 78.01 9.84 3 21 P51571 Translocon-associated protein subunits delta SSR4 Homo sapiens 74.54 24.86 3 21 Q15836 Vesicle-associated membrane protein 3 VAMP3 Homo sapiens 72.83 33.00 2 21 Q14847 LIM and SH3 domain protein 1 LASP1 Homo sapiens 67.61 17.62 4 21 Q99584 Protein S100-A13 S100A13 Homo sapiens 65.57 23.47 2 21 Q9Y277 Voltage-dependent anion-selective channel VDAC3 Homo sapiens 62.19 12.01 3 21 protein 3 P13797 Plastin-3 PLS3 Homo sapiens 62.18 14.76 7 21 P02533 Keratin, type I cytoskeletal 14 KRT14 Homo sapiens 61.78 16.74 7 21 P60981 Destrin DSTN Homo sapiens 60.55 20.00 3 21 Q15417 Calponin-3 CNN3 Homo sapiens 55.43 13.98 4 21 Q9BS26 Endoplasmic reticulum resident protein 44 ERP44 Homo sapiens 112.39 11.58 3 20 O94973 AP-2 complex subunit alpha-2 AP2A2 Homo sapiens 87.35 7.24 4 20 O14579 Coatomer subunit epsilon COPE Homo sapiens 84.58 19.48 5 20 O14773 Tripeptidyl-peptidase 1 TPP1 Homo sapiens 80.43 8.17 3 20 P13987 CD59 glycoprotein CD59 Homo sapiens 70.28 18.75 2 20 P31937 3-hydroxyisobutyrate dehydrogenase, HIBADH Homo sapiens 69.39 7.14 2 20 mitochondrial P46778 60S ribosomal protein L21 RPL21 Homo sapiens 68.85 27.50 3 20 Q16363 Laminin subunit alpha-4 LAMA4 Homo sapiens 66.46 2.14 3 20 P15586 N-acetylglucosamine-6-sulfatase GNS Homo sapiens 60.55 6.88 3 20 P11940 Polyadenylate-binding protein 1 PABPC1 Homo sapiens 54.28 7.55 4 20 P30040 Endoplasmic reticulum resident protein 29 ERP29 Homo sapiens 54.08 14.18 3 20 Q9Y3F4 Serine-threonine kinase receptor-associated STRAP Homo sapiens 86.18 8.86 2 19 protein Q7L2H7 Eukaryotic translation initiation factor 3 subunit M EIF3M Homo sapiens 74.90 15.78 4 19 Q9Y3I0 tRNA-splicing ligase RtcB homolog RTCB Homo sapiens 73.48 13.47 4 19 Q9NVJ2 ADP-ribosylation factor-like protein 8B ARL8B Homo sapiens 72.73 19.89 2 19 P04632 Calpain small subunit 1 CAPNS1 Homo sapiens 72.63 16.42 3 19 P00568 Adenylate kinase isoenzyme 1 AK1 Homo sapiens 68.07 31.96 4 19 P42224 Signal transducer and activator of transcription STAT1 Homo sapiens 67.24 9.73 5 19 1-alpha/beta Q02878 60S ribosomal protein L6 RPL6 Homo sapiens 66.73 15.63 3 19 O94979 Protein transport protein Sec31A SEC31A Homo sapiens 58.06 3.11 3 19 P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP5 Homo sapiens 56.52 2.68 2 19 P38159 RNA-binding motif protein, X chromosome RBMX Homo sapiens 54.92 8.70 3 19 Q13557 Calcium/calmodulin-dependent protein kinase CAMK2D Homo sapiens 51.92 11.02 4 19 type II subunit delta P84074 Neuron-specific calcium-binding protein HPCA Homo sapiens 48.64 19.69 3 19 hippocalcin P40227 T-complex protein 1 subunit zeta CCT6A Homo sapiens 87.47 9.23 3 18 O43242 26S proteasome non-ATPase regulatory PSMD3 Homo sapiens 79.83 7.68 3 18 subunit 3 P30084 Enoyl-CoA hydratase, mitochondrial ECHS1 Homo sapiens 78.24 13.10 2 18 O00410 Importin-5 IPO5 Homo sapiens 78.12 7.66 5 18 P46777 60S ribosomal protein L5 RPL5 Homo sapiens 71.13 23.91 5 18 Q15008 26S proteasome non-ATPase regulatory PSMD6 Homo sapiens 69.46 7.20 2 18 subunit 6 O15511 Actin-related protein 2/3 complex subunit 5 ARPC5 Homo sapiens 66.82 29.14 3 18 Q15436 Protein transport protein Sec23A SEC23A Homo sapiens 61.38 3.53 2 18 P19623 Spermidine synthase SRM Homo sapiens 59.81 21.19 4 18 Q02809 Procollagen-lysine, 2-oxoglutarate 5- PLOD1 Homo sapiens 58.99 5.91 3 18 dioxygenase 1 P62081 40S ribosomal proten S7 RPS7 Homo sapiens 58.91 17.53 2 18 P25789 Proteasome subunit alpha type-4 PSMA4 Homo sapiens 47.57 13.03 2 18 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate GRHPR Homo sapiens 84.31 17.38 3 17 reductase P20618 Proteasome subunit beta type-1 PSMB1 Homo sapiens 77.13 15.35 2 17 P21964 Catechol O-methyltransferase COMT Homo sapiens 76.86 8.49 2 17 O15460 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 Homo sapiens 75.70 11.03 4 17 P62191 26S protease regulatory subunit 4 PSMC1 Homo sapiens 75.48 10.91 3 17 P63167 Dynein light chain 1, cytoplasmic DYNLL1 Homo sapiens 72.59 37.08 2 17 P09429 High mobility group protein B1 HMGB1 Homo sapiens 72.42 20.93 3 17 Q13724 Mannosyl-oligosaccharide glucosidase MOGS Homo sapiens 70.23 7.53 4 17 P19367 Hexokinase-1 HK1 Homo sapiens 64.34 8.62 6 17 P23526 Adenosylhomocysteinase AHCY Homo sapiens 62.16 10.65 3 17 P39023 60S ribosomal protein L3 RPL3 Homo sapiens 58.60 17.87 5 17 P10301 Ras-related protein R-Ras RRAS Homo sapiens 55.83 12.84 2 17 Q96CW1 AP-2 complex sabunit mu AP2M1 Homo sapiens 55.49 12.87 4 17 P61353 60S ribosomal protein L27 RPL27 Homo sapiens 54.78 27.94 3 17 P11279 Lysosome-associated membrane glycoprotein 1 LAMP1 Homo sapiens 54.76 6.63 3 17 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 Homo sapiens 53.67 3.81 2 17 P62266 40S ribosomal protein S23 RPS23 Homo sapiens 53.61 13.99 2 17 P22695 Cytochrome b-c1 complex subunit 2, UQCRC2 Homo sapiens 67.34 13.91 4 16 mitochondrial P36543 V-type proton ATPase subunit E1 ATP6V1E1 Homo sapiens 65.25 6.19 2 16 P61604 10 kDa heat shock protein, mitochondrial HSPE1 Homo sapiens 58.13 33.33 3 16 P40261 Nicotinamide N-methyltransferase NNMT Homo sapiens 57.15 18.18 3 16 Q63ZY3 KN motif and ankyrin repeat domain- KANK2 Homo sapiens 56.52 4.70 3 16 containing protein 2 P21266 Glutathione S-transferase Mu 3 GSTM3 Homo sapiens 53.50 20.44 4 16 O15260 Surfeit locus protein 4 SURF4 Homo sapiens 53.47 8.55 2 16 P05455 Lupus La protein SSB Homo sapiens 50.85 12.99 4 16 O15144 Actin-related protein 2/3 complex subunit 2 ARPC2 Homo sapiens 50.68 12.67 4 16 Q6NUM9 All-trans-retinol 13,14-reductase RETSAT Homo sapiens 49.04 4.92 2 16 O43143 Putative pre-mRNA-splicing factor ATP- DHX15 Homo sapiens 47.67 2.89 2 16 dependent RNA helicase DHX15 Q9Y3U8 60S ribosomal protein L36 RPL36 Homo sapiens 47.12 30.48 4 16 P42677 40S ribosomal protein S27 RPS27 Homo sapiens 46.35 25.00 2 16 P26640 Valine-tRNA ligase VARS Homo sapiens 44.08 3.64 4 16 P26908 Collagen alpha-1(V) chain COL5A1 Homo sapiens 17.63 3.10 3 16 P35613 Basigin BSG Homo sapiens 47.61 8.31 2 15 P07711 Cathepsin L1 CTSL Homo sapiens 46.98 8.41 2 15 O94905 Erlin-2 ERLIN2 Homo sapiens 45.32 10.91 3 15 P31948 Stress-induced-phosphoprotein 1 STIP1 Homo sapiens 41.60 9.39 4 15 P13473 Lysosome-associated membrane glycoprotein 2 LAMP2 Homo sapiens 41.41 7.07 3 15 P61970 Nuclear transport factor 2 NUTF2 Homo sapiens 67.00 33.86 2 14 P46439 Glutathione S-transferase Mu 5 GSTM5 Homo sapiens 65.44 11.93 2 14 Q8IWE2 Protein NOXP20 FAM114A1 Homo sapiens 63.09 5.68 2 14 Q92597 Protein NDRG1 NDRG1 Homo sapiens 61.64 8.88 2 14 O75533 Splicing factor 3B subunit 1 SF3B1 Homo sapiens 60.00 2.45 2 14 O75368 SH3 domain-binding glutamic acid-rich-like SH3BGRL Homo sapiens 53.79 37.72 3 14 protein P23246 Splicing factor, proline- and glutamine-rich SFPQ Homo sapiens 52.82 9.05 5 14 Q08380 Galectin-3-binding protein LGALS3BP Homo sapiens 51.25 7.52 3 14 O60763 General vesicular transport factor p115 USO1 Homo sapiens 48.56 3.85 3 14 P46977 Dolichyl-diphosphooligosaccharide--protein STT3A Homo sapiens 47.82 5.25 3 14 glycosyltransferase subunit STT3A Q15075 Early endsome antigen 1 EEA1 Homo sapiens 47.08 3.97 4 14 O95816 BAG family molecular chaperone regulator 2 BAG2 Homo sapiens 47.06 13.27 2 14 Q9NR45 Sialic acid synthase NANS Homo sapiens 46.21 15.88 3 14 P51858 Hepatoma-derived growth factor HDGF Homo sapiens 45.76 14.17 3 14 P00505 Aspartate aminotransferase, mitochondrial GOT2 Homo sapiens 45.71 14.42 5 14 Q01105 Protein SET SET Homo sapiens 45.04 12.07 3 14 P61019 Ras-related protein Rab-2A RAB2A Homo sapiens 42.23 10.85 2 14 P19404 NADH dehydrogenase [ubiquinone] NDUFV2 Homo sapiens 41.82 9.24 2 14 flavoprotein 2, mitochondrial P55884 Eukaryotic translation initiation factor 3 subunit B EIF3B Homo sapiens 40.54 5.90 4 14 Q13425 Beta-2-syntrophin SNTB2 Homo sapiens 39.75 3.89 2 14 P54136 Arginine--tRNA ligase, cytoplasmic RARS Homo sapiens 38.18 6.97 4 14 P49773 Histidine triad nucleotide-binding protein 1 HINT1 Homo sapiens 83.21 34.92 2 13 P27695 DNA-(apurinic or apyrimidinic site) lyase APEX1 Homo sapiens 63.88 22.96 4 13 Q53GQ0 Estradiol 17-beta-dehydrogenase 12 HSD17B12 Homo sapiens 54.92 9.62 2 13 Q5T9L3 Protein wntless homolog WLS Homo sapiens 54.68 8.13 3 13 O14880 Microsomal glutathione S-transferase 3 MGST3 Homo sapiens 54.48 23.03 2 13 P07954 Fumarate hydratase, mitochondrial FH Homo sapiens 53.05 7.45 2 13 Q8IZP2 Putative protein FAM10A4 ST13P4 Homo sapiens 51.61 17.08 3 13 O75131 Copine-3 CPNE3 Homo sapiens 50.89 10.80 3 13 P14854 Cytochrome c oxidase subunit 6B1 COX6B1 Homo sapiens 50.34 33.72 2 13 Q9UIJ7 GTP:AMP phosphotransferase AK3, AK3 Homo sapiens 50.04 12.78 2 13 mitochondrial P23381 Tryptophan-tRNA ligase, cytoplasmic WARS Homo sapiens 50.02 5.73 2 13 Q12906 Interleukin enhancer-binding factor 3 ILF3 Homo sapiens 49.53 12.53 7 13 P27487 Dipeptidyl peptidase 4 DPP4 Homo sapiens 48.49 6.66 4 13 Q9BWD1 Acetyl-CoA acetyltransferase, cylosolic ACAT2 Homo sapiens 47.57 14.61 3 13 P43243 Matrin-3 MATR3 Homo sapiens 46.57 6.02 3 13 P55010 Eukaryotic translation initiation factor 5 EIF5 Homo sapiens 45.49 9.98 3 13 P04179 Superoxide dismutase [Mn], mitochondrial SOD2 Homo sapiens 43.52 22.97 4 13 P62330 ADP-ribosylation factor 6 ARF6 Homo sapiens 40.96 24.57 3 13 P41252 Isoleucine--tRNA ligase, cytoplasmic IARS Homo sapiens 38.88 4.75 5 13 P04062 Glucosylceramidase GBA Homo sapiens 36.15 7.09 3 13 P60900 Proteasome subunit alpha type-6 PSMA6 Homo sapiens 36.13 10.16 2 13 O43491 Band 4.1-like protein 2 EPB41L2 Homo sapiens 51.57 6.57 4 12 P10768 S-formylglutathione hydrolase ESD Homo sapiens 48.41 10.64 2 12 P36957 Dihydrolipoyliysine-residue DLST Homo sapiens 46.29 7.73 2 12 succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial P61254 60S ribosomal protein L26 RPL26 Homo sapiens 39.66 12.41 2 12 O15145 Actin-related protein 2/3 complex subunit 3 ARPC3 Homo sapiens 39.11 13.48 2 12 P08195 4F2 cell-surface antigen heavy chain SLC3A42 Homo sapiens 38.01 4.13 2 12 Q9UKK3 Poly [ADP-ribose] polymerase 4 PARP4 Homo sapiens 37.80 1.68 2 12 Q03252 Lamin-B2 LMNB2 Homo sapiens 35.36 7.83 5 12 O95747 Serine/threonine-protein kinase OSR1 OXSR1 Homo sapiens 35.02 4.93 2 12 P39656 Dolichyl-diphosphooligosaccharide--protein DDOST Homo sapiens 33.93 12.28 5 12 glycosyltransferase 48 kDa subunit P78344 Eukaryotic translation initiation factor 4 EIF4G2 Homo sapiens 31.94 2.32 2 12 gamma 2 Q6IBS0 Twinfilin-2 TWF2 Homo sapiens 46.21 15.19 3 11 P22087 rRNA 2-O-methyltransferase fibrillarin FBL Homo sapiens 45.97 9.35 2 11 Q96KP4 Cytosolic non-specific dipeptidase CNDP2 Homo sapiens 44.17 6.74 2 11 P09622 Dihydrolipoyl dehydrogenase, mitochondrial DLD Homo sapiens 42.94 6.48 2 11 Q99798 Aconitate hydratase, mitochondrial ACO2 Homo sapiens 42.91 7.18 3 11 P04040 Catalase CAT Homo sapiens 42.83 11.20 4 11 Q07666 KH domain-containing, RNA-binding, signal KHDRBS1 Homo sapiens 42.69 7.67 2 11 transduction-associated protein 1 P07942 Laminin subunit beta-1 LAMB1 Homo sapiens 41.56 2.07 2 11 P00390 Glutathione reduclase, mitochondrial GSR Homo sapiens 39.02 6.32 2 11 Q9Y371 Endophilin-B1 SH3GLB1 Homo sapiens 38.47 6.85 2 11 P62195 26S protease regulatory subunit 8 PSMC5 Homo sapiens 37.79 12.07 3 11 Q9BWM7 Sideroflexin-3 SFXN3 Homo sapiens 35.68 11.69 3 11 P00403 Cytochrome c oxidase subunit 2 MT-CO2 Homo sapiens 35.42 11.45 2 11 O43615 Mitochondrial import inner membrane C3 Homo sapiens 33.97 5.09 2 11 translocase subunit TIM44 P30046 D-dopachrome decarboxylase TIMM44 Homo sapiens 33.74 19.49 2 11 Q32P28 Prolyl 3-hydroxylase 1 DDT Homo sapiens 32.20 3.40 2 11 P30740 Leukocyte elastase inhibitor LEPRE1 Homo sapiens 31.82 6.60 2 11 Q9ULV4 Coronin-1C SERPINB1 Homo sapiens 30.15 4.85 2 11 Q60488 Long-chain-fatty-acid--CoA ligase 4 CORO1C Homo sapiens 29.03 4.36 2 11 P01026 Complement C3 [Cleaved into: Complement ACSL4 Rattus norvegicus 34.28 1.74 2 11 C3 beta chain; Complement C3 alpha chain] Q16643 Drebrin DBN1 Homo sapiens 48.88 8.63 3 10 Q02952 A-kinase anchor protein 12 AKAP12 Homo sapiens 48.74 6.51 5 10 P28161 Glutathione S-transferase Mu 2 GSTM2 Homo sapiens 47.15 33.03 5 10 O75367 Core histone macro-H2A.1 H24FY Homo sapiens 42.46 15.59 3 10 O14980 Exportin-1 XPO1 Homo sapiens 42.26 6.35 4 10 P38606 V-type proton ATPase catalytic subunit A ATP6V1A Homo sapiens 40.66 8.91 3 10 O00151 PDZ and LIM domain protein 1 PDLIM1 Homo sapiens 39.15 15.20 3 10 P14868 Aspartate--tRNA ligase, cytoplasmic DARS Homo sapiens 37.60 7.98 3 10 Q13418 Integrin-linked protein kinase ILK Homo sapiens 37.04 9.73 3 10 Q14195 Dihydropyrimidinase-related protein 3 DPYSL3 Homo sapiens 36.24 19.12 6 10 P49589 Cysteine-tRNA ligase, cytoplasmic CARS Homo sapiens 34.54 4.68 2 10 P18621 60S ribosomal protein L17 RPL17 Homo sapiens 34.48 13.59 3 10 P06756 Integrin alpha-V ITGAV Homo sapiens 34.31 7.35 4 10 O75351 Vacuolar protein sorting-associated protein 4B VPS4B Homo sapiens 32.55 6.98 2 10 P02786 Transferrin receptor protein 1 TFRC Homo sapiens 31.04 2.89 2 10 Q9NQW7 Xaa-Pro aminopeptidase 1 XPNPEP1 Homo sapiens 30.08 4.82 2 10 Q99961 Endophlin-A2 SH3GL1 Homo sapiens 30.00 12.23 3 10 P34897 Serine hydroxymethyltransferase, SHMT2 Homo sapiens 29.51 7.54 3 10 mitochondrial P06865 Beta-hexosaminidase subunit alpha HEXA Homo sapiens 29.46 6.24 3 10 Q13263 Transcription intermediary factor 1-beta TRIM28 Homo sapiens 26.56 5.87 3 10 Q02543 60S ribosomal protein L18a RPL18A Homo sapiens 25.80 9.66 2 10 P16401 Histone H1.5 HIST1H1B Homo sapiens 25.79 10.18 2 10 P48643 T-complex protein 1 subunit epsilon CCT5 Homo sapiens 40.56 15.71 5 9 P48147 Prolyl endopeptidase PREP Homo sapiens 36.97 5.49 2 9 P61769 Beta-2-microglobulin [Cleaved into: Beta-2- B2M Homo sapiens 35.59 35.29 3 9 microglobulin form pl 5.3] Q13228 Selenium-binding protein 1 SELENBP1 Homo sapiens 34.80 11.65 4 9 P09960 Leukotriene A-4 hydrolase LTA4H Homo sapiens 34.51 6.71 3 9 Q92882 Osteoclast-stimulating factor 1 OSTF1 Homo sapiens 33.24 17.29 2 9 P43490 Nicotinamide phosphoribosyltransferase NAMPT Homo sapiens 32.14 8.35 2 9 P12268 Inosine-5-monophosphate dehydrogenase 2 IMPDH2 Homo sapiens 31.91 5.84 2 9 P22102 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine- GART Homo sapiens 31.74 2.67 2 9 glycine ligase] P13804 Electron transfer flavoprotein subunit alpha, ETFA Homo sapiens 29.91 13.81 3 9 mitochondrial P62714 Serine/threonine-protein phosphatase 2A PPP2CB Homo sapiens 29.25 16.50 3 9 catalytic subunit beta isoform P13798 Acylamino-acid-releasing enzyme APEH Homo sapiens 29.20 4.78 2 9 O95336 6-phosphogluconolactonase PGLS Homo sapiens 29.02 17.05 3 9 Q14112 Nidogen-2 NID2 Homo sapiens 28.75 2.76 3 3 P20073 Annexin A7 ANXA7 Homo sapiens 28.58 8.40 3 9 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 ERAP1 Homo sapiens 27.64 4.36 3 9 Q13561 Dynactin subunit 2 DCTN2 Homo sapiens 27.33 8.23 2 9 Q9UEY8 Gamma-adducin ADD3 Homo sapiens 26.05 7.51 4 9 Q9UHL4 Dipeptidyl peptidase 2 DPP7 Homo sapiens 25.73 4.47 2 9 Q92841 Probable ATP-dependent RNA helicase DDX17 Homo sapiens 25.28 6.17 4 9 DDX17 P62910 60S ribosomal protein L32 RPL32 Homo sapiens 24.56 27.41 3 9 Q16401 26S proteasome non-ATPase regulatory PSMD5 Homo sapiens 30.76 9.33 3 8 subunit 5 Q02818 Nucleobindin-1 NUCB1 Homo sapiens 30.34 6.29 2 8 Q9NTK5 Obg-like ATPase 1 OLA1 Homo sapiens 30.03 8.33 2 8 Q9UHG3 Prenylcysteine oxidase 1 PCYOX1 Homo sapiens 29.06 7.33 2 8 P08473 Neprilysin MME Homo sapiens 26.86 10.40 5 8 P84098 60S ribosomal protein L19 RPL19 Homo sapiens 26.10 13.27 2 8 P19823 Inter-alpha-trypsin inhibitor heavy chain H2 ITIH2 Homo sapiens 25.74 2.75 2 8 P30626 Sorcin SRI Homo sapiens 24.78 11.11 2 8 Q9NYL9 Tropomodulin-3 TMOD3 Homo sapiens 24.64 7.10 2 8 P53999 Activated RNA polymerase II transcriptional SUB1 Homo sapiens 23.69 18.90 2 8 coactivator p15 Q9UJ70 N-acetyl-D-glucosamine kinase NAGK Homo sapiens 23.68 11.92 3 8 P62851 40S ribosomal protein S25 RPS25 Homo sapiens 23.28 16.00 2 8 P0CW22 40S ribosomal protein S17-like RPS17L Homo sapiens 23.16 15.56 2 8 P80303 Nucleobindin-2 NUCB2 Homo sapiens 22.85 5.95 2 8 P28845 Corticosteroid 11-beta-dehydrogenase HSD11B1 Homo sapiens 22.65 10.96 2 8 isozyme 1 O43237 Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 Homo sapiens 22.33 5.08 2 8 Q9NYU2 UDP-glucose:glycoprotein glycosyltransferase 1 UGGT1 Homo sapiens 22.30 3.79 4 8 Q9Y4L1 Hypoxia up-regulated protein 1 HYOU1 Homo sapiens 20.71 2.80 2 8 P05023 Sodium/potassium-transporting ATPase ATP1A1 Homo sapiens 20.70 3.52 3 8 subunit alpha-1 P54727 UV excision repair protein RAD23 homolog B RAD23B Homo sapiens 30.83 7.09 2 7 O75955 Flotilin-1 FLOT1 Homo sapiens 29.59 6.79 2 7 P49591 Serine-tRNA ligase, cytoplasmic SARS Homo sapiens 29.21 11.67 3 7 P46063 ATP-dependent DNA helicase Q1 RECQL Homo sapiens 28.61 5.08 2 7 P53007 Tricarboxylate transport protein, mitochondrial SLC25A1 Homo sapiens 25.56 11.25 3 7 Q9UQ80 Proliferation-associated protein 2G4 PA2G4 Homo sapiens 25.34 8.38 2 7 O94855 Protein transport protein Sec24D SEC24D Homo sapiens 23.19 2.71 2 7 P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 Homo sapiens 23.16 13.73 4 7 Q15847 Adipogenesis regulatory factor ADIRF Homo sapiens 22.08 59.21 2 7 Q9UM54 Unconventional myosin-VI MYO6 Homo sapiens 21.91 2.16 2 7 P42765 3-ketoacyl-CoA thiolase, mitochondrial ACAA2 Homo sapiens 21.44 7.81 2 7 Q9NR31 GTP-binding protein SAR1a SAR1A Homo sapiens 21.19 21.72 3 7 P99999 Cytochrome c CYCS Homo sapiens 20.83 24.76 2 7 Q9HC38 Glyoxalase domain-containing protein 4 GLOD4 Homo sapiens 20.63 7.35 2 7 Q99832 T-complex protein 1 subunit eta CCT7 Homo sapiens 20.23 4.79 2 7 Q5SSJ5 Heterochromatin protein 1-binding protein 3 HP1BP3 Homo sapiens 19.85 4.70 2 7 P36405 ADP-ribosylation factor-like protein 3 ARL3 Homo sapiens 19.10 12.64 2 7 P50281 Matrix metalloproteinase-14 MMP14 Homo sapiens 19.03 4.12 2 7 P40429 60S ribosomal protein L13a RPL13A Homo sapiens 18.87 8.87 2 7 Q13510 Acid ceramidase ASAH1 Homo sapiens 30.44 10.13 2 6 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Homo sapiens 25.28 16.48 2 6 Q13423 NAD(P) transhydrogenase, mitochondrial NNT Homo sapiens 24.97 4.51 3 6 P29966 Myristoylated alanine-rich C-kinase substrate MARCKS Homo sapiens 24.68 25.00 3 6 O43681 ATPase ASNA1 ASNA1 Homo sapiens 22.72 8.91 2 6 P05198 Eukaryotic translation initiation factor 2 subunit 1 EIF2S1 Homo sapiens 21.96 14.92 3 6 P55036 26S proteasome non-ATPase regulatory PSMD4 Homo sapiens 21.86 11.94 3 6 subunit 4 P26368 Splicing factor U2AF 65 kDa subunit U2AF2 Homo sapiens 21.60 6.11 2 6 P49189 4-trimethylaminobutyraldehyde ALDH9A1 Homo sapiens 20.13 5.26 2 6 dehydrogenase P09936 Ubiquitin carboxyl-terminal hydrolase isozyme UCHL1 Homo sapiens 19.71 14.35 2 6 L1 Q02218 2-oxoglutarate dehydrogenase, mitochondrial OGDH Homo sapiens 19.31 5.38 4 6 Q9UNM6 26S proteasome non-ATPase, regulatory PSMD13 Homo sapiens 18.66 9.57 3 6 subunit 13 P09110 3-ketoacyl-CoA thiolase, peroxisomal ACAA1 Homo sapiens 18.52 7.78 2 6 Q9P2J5 Leucine--tRNA ligase, cytoplasmic LARS Homo sapiens 17.83 1.79 2 6 P10515 Dihydrolipoyllysine-residue acetyltransferase DLAT Homo sapiens 17.46 4.48 2 6 component of pyruvate dehydrogenase complex, mitochondrial Q9Y262 Eukaryotic translation initiation factor 3 subunit L EIF3L Homo sapiens 17.30 3.55 2 6 P55735 Protein SEC13 homolog SEC13 Homo sapiens 17.22 13.35 3 6 P25788 Proteasome subunit alpha type-3 PSMA3 Homo sapiens 17.13 14.12 3 6 P32969 60S ribosomal protein L9 RPL9 Homo sapiens 16.93 11.46 3 6 Q16891 Mitochondrial inner membrane protein IMMT Homo sapiens 16.26 4.35 2 6 Q16531 DNA damage-binding protein 1 DDB1 Homo sapiens 24.08 3.07 2 5 P49419 Alpha-aminoadipic semialdehyde ALDH7A1 Homo sapiens 19.67 5.94 2 5 dehydrogenase P05413 Fatty acid-binding protein, heart FABP3 Homo sapiens 19.47 31.58 3 5 P80723 Brain acid soluble protein 1 BASP1 Homo sapiens 19.41 18.50 2 5 Q92905 COP9 signalosome complex subunit 5 COPS5 Homo sapiens 17.81 6.89 2 5 P54578 Ubiquitin carboxyl-terminal hydrolase 14 USP14 Homo sapiens 16.08 5.87 2 5 Q12884 Seprase FAP Homo sapiens 15.64 2.76 2 5 Q9P0L0 Vesicle-associated membrane protein- VAPA Homo sapiens 15.58 11.24 2 5 associated protein A P10253 Lysosomal alpha-glucosidase GAA Homo sapiens 15.19 3.05 2 5 Q99439 Calponin-2 CNN2 Homo sapiens 15.15 12.30 3 5 Q969H8 UPF0556 protein C19orf10 C19ORF10 Homo sapiens 14.99 15.03 2 5 P00491 Purine nucleoside phosphorylase PNP Homo sapiens 14.91 9.69 2 5 Q9NSE4 Isoleucine--tRNA ligase, mitochondrial IARS2 Homo sapiens 14.69 3.16 3 5 Q09028 Histone-binding protein RBBP4 RBBP4 Homo sapiens 14.18 4.94 2 5 P52630 Signal transducer and activator of transcription 2 STAT2 Homo sapiens 13.75 2.82 2 5 P08648 Integrin alpha-5 ITGA5 Homo sapiens 12.87 2.00 2 5 P06454 Prothymosin alpha [Cleaved into: Prothymosin PTMA Homo sapiens 12.15 20.72 2 5 alpha, N-terminally processed; Thymosin alpha-1] P43304 Glycerol-3-phosphate dehydrogenase, GPD2 Homo sapiens 18.91 4.81 2 4 mitochondrial Q9ULZ3 Apoptosis-associated speck-like protein PYCARD Homo sapiens 17.85 12.82 2 4 containing a CARD O00154 Cytosolic acyl coenzyme A thioester hydrolase ACOT7 Homo sapiens 17.76 9.47 2 4 P21291 Cysteine and glycine-rich protein 1 CSRP1 Homo sapiens 16.70 20.21 2 4 P27701 CD82 antigen CD82 Homo sapiens 15.88 10.49 2 4 P11586 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Homo sapiens 15.19 5.24 3 4 Q6IAA8 Ragulator complex protein LAMTOR1 LAMTOR1 Homo sapiens 15.17 15.53 2 4 O15230 Laminin subunit alpha-5 LAMA5 Homo sapiens 14.56 0.97 2 4 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 PRPF8 Homo sapiens 14.44 1.24 2 4 O60437 Periplakin PPL Homo sapiens 14.03 3.13 3 4 Q96FQ6 Protein S100-A16 S100A16 Homo sapiens 13.82 22.33 2 4 O00303 Eukaryotic translation initiation factor 3 subunit F EIF3F Homo sapiens 13.71 7.28 2 4 P43487 Ran-specific GTPase-activating protein RANBP1 Homo sapiens 13.26 16.92 2 4 O00425 Insulin-like growth factor 2 mRNA-binding IGF2BP3 Homo sapiens 12.21 5.18 2 4 protein 3 Q9Y230 RuvB-like 2 RUVBL2 Homo sapiens 12.00 9.50 3 4 P55060 Exportin-2 CSE1L Homo sapiens 11.83 3.40 2 4 P20674 Cytochrome c oxidase subunit 5A, COX5A Homo sapiens 11.58 16.00 2 4 mitochondrial P35611 Alpha-adducin ADD1 Homo sapiens 11.18 4.21 2 4 P10644 cAMP-dependent protein kinase type I-alpha PRKAR1A Homo sapiens 11.12 9.19 2 4 regulatory subunit Q9NUQ9 Protein FAM49B FAM49B Homo sapiens 10.88 8.64 2 4 O95302 Peptidyl-prolyl cis-trans isomerase FKBP9 FKBP9 Homo sapiens 10.34 4.56 2 4 P63220 40S ribosomal protein S21 RPS21 Homo sapiens 10.11 22.89 2 4 P49720 Proteasome subunit beta type-3 PSMB3 Homo sapiens 12.83 15.12 2 3 P62491 Ras-related protein Rab-11A RAB11A Homo sapiens 12.02 11.11 2 3 Q2TAA2 Isoamyl acelate-hydrolyzing esterase 1 IAH1 Homo sapiens 12.02 10.89 2 3 homolog Q08257 Quinone oxidoreductase CRYZ Homo sapiens 11.77 10.64 2 3 O75694 Nuclear pore complex protein Nup155 NUP155 Homo sapiens 11.59 2.23 2 3 Q14247 Src substrate cortactin CTTN Homo sapiens 10.48 4.73 2 3 Q8IVL6 Prolyl 3-hydroxylase 3 LEPREL2 Homo sapiens 10.19 4.21 2 3 P00492 Hypoxanthine-guanine HPRT1 Homo sapiens 9.71 10.55 2 3 phosphoribosyltransferase Q9P0J0 NADH dehydrogenase [ubiquinone] 1 alpha NDUFA13 Homo sapiens 9.66 9.72 2 3 subcomplex subunit 13 Q86UP2 Kinectin KTN1 Homo sapiens 9.51 2.21 2 3 O75489 NADH dehydrogenase [ubiquinone] iron-sulfur NDUFS3 Homo sapiens 9.34 15.53 3 3 protein 3, mitochondrial Q9UL46 Proteasome activator complex subunit 2 PSME2 Homo sapiens 8.76 12.13 2 3 Q13057 Bifunctional coenzyme A synthase COASY Homo sapiens 8.68 4.96 2 3 P48163 NADP-dependent malic enzyme ME1 Homo sapiens 8.67 5.24 2 3 Q13488 V-type proton ATPase 116 kDa subunit a TCIRG1 Homo sapiens 8.61 2.65 2 3 isoform 3 Q9H845 Acyl-CoA dehydrogenase family member 9, ACAD9 Homo sapiens 8.54 4.35 2 3 mitochondrial P60228 Eukaryotic translation initiation factor 3 subunit E EIF3E Homo sapiens 8.48 4.94 2 3 Q15758 Neutral amino acid transporter B(0) SLC1A5 Homo sapiens 7.94 4.44 2 3 Q96AC1 Fermitin family homolog 2 FERMT2 Homo sapiens 7.61 3.82 2 3 P22234 Multifunctional protein ADE2 [Includes: PAICS Homo sapiens 7.51 6.59 2 3 Phosphoribosylaminoimidazole- succinocarboxamide synthase] P14923 Junction plakoglobin JUP Homo sapiens 9.12 3.76 2 2 Q687X5 Metalloreductase STEAP4 STEAP4 Homo sapiens 8.11 7.19 2 2 P18859 ATP synthase-coupling factor 6, mitochondrial ATP5J Homo sapiens 7.62 26.85 2 2 Q14766 Latent-transforming growth factor beta-binding LTBP1 Homo sapiens 7.23 1.69 2 2 protein 1 Q6YHK3 CD109 antigen CD109 Homo sapiens 7.08 1.87 2 2 O14737 Programmed cell death protein 5 PDCD5 Homo sapiens 6.87 19.20 2 2 Q9Y3B3 Transmembrane emp24 domain-containing TMED7 Homo sapiens 6.13 11.16 2 2 protein 7 Q9Y240 C-type lectin domain family 11 member A CLEC11A Homo sapiens 6.11 8.98 2 2 P48735 Isocitrate dehydrogenase [NADP] IDH2 Homo sapiens 6.06 5.97 2 2 mitochondrial P42704 Leucine-rich PPR motif-containing protein, LRPPRC Homo sapiens 5.73 2.22 2 2 mitochondrial Q15819 Ubiquitin-conjugating enzyme E2 variant 2 UBE2V2 Homo sapiens 5.19 13.79 2 2 Q9C0C2 182 kDa tankyrase-1-binding protein TNKS1BP1 Homo sapiens 4.83 1.56 2 2 Native VF mucosa P02768 Serum albumin ALB Homo sapiens 9377.55 78.49 52 2323 P02452 Collagen alpha-1(I) chain COL1A1 Homo sapiens 1727.89 43.65 37 2130 P12109 Collagen alpha-1(VI) chain COL6A1 Homo sapiens 3245.57 49.22 34 1464 P12111 Collagen alpha-3(VI) chain COL6A3 Homo sapiens 5535.48 37.46 92 1447 P08123 Collagen alpha-2(I) chain COL1A2 Homo sapiens 1753.82 37.70 31 1416 P02461 Collagen alpha-1(III) chain COL3A1 Homo sapiens 1145.04 33.77 30 1365 P13647 Keratin, type II cytoskeletal 5 KRT5 Homo sapiens 4377.87 61.36 49 1272 Q9UKX2 Myosin-2 MYH2 Homo sapiens 5300.08 60.79 135 1228 P35555 Fibrilin-1 FBN1 Homo sapiens 4497.74 38.56 75 1166 P02675 Fibrinogen beta chain FGB Homo sapiens 3486.23 70.67 30 1070 P12882 Myosin-1 MYH1 Homo sapiens 4537.67 58.17 125 1060 P13646 Keratin, type I cytoskeletal 13 KRT13 Homo sapiens 3623.18 63.97 34 1001 P02538 Keratin, type II cytosketetal 6A KRT6A Homo sapiens 3925.12 63.48 46 999 Q09666 Neuroblast differentiation-associated protein AHNAK Homo sapiens 3348.49 37.64 95 933 AHNAK P35579 Myosin-9 MYH9 Homo sapiens 3935.56 49.29 81 909 P22105 Tenascin-X TNXB Homo sapiens 3631.59 35.42 90 902 P04259 Keratin, type II cytoskeletal 6B KRT6B Homo sapiens 3609.25 56.91 42 900 P01024 Complement C3 C3 Homo sapiens 3126.18 51.11 63 763 P02533 Keratin, type I cytoskeletal 14 KRT14 Homo sapiens 2848.68 71.19 35 756 P08727 Keratin, type I cytoskeletal 19 KRT19 Homo sapiens 2653.17 84.50 36 731 P15924 Desmoplakin DSP Homo sapiens 2903.43 35.36 84 725 P60709 Actin, cytoplasmic 1 ACTB Homo sapiens 2698.92 64.00 18 696 Q15149 Plectin PLEU Homo sapiens 2779.52 29.76 97 696 P19013 Keratin, type II cytoskeletal 4 KRT4 Homo sapiens 2651.92 62.73 35 685 P02679 Fibrinogen gamma chain FGG Homo sapiens 2758.21 77.04 29 677 P68133 Actin, alpha skeletal muscle ACTA1 Homo sapiens 2630.03 66.84 20 663 P01023 Alpha-2-macroglobulin A2M Homo sapiens 2609.50 51.76 51 560 P12110 Collagen alpha-2(VI) chain COL6A2 Homo sapiens 1699.58 37.49 33 649 P68032 Actin, alpha cardiac muscle 1 ACTC1 Homo sapiens 2619.50 66.84 20 645 P12883 Myosin-7 MYH7 Homo sapiens 2691.89 52.20 97 637 P02671 Fibrinogen alpha chain FGA Homo sapiens 1988.48 41.22 32 621 P08670 Vimentin VIM Homo sapiens 2279.55 71.46 37 596 Q8WZ42 Titin TTN Homo sapiens 2540.73 10.62 200 584 P02787 Serotransferrin TF Homo sapiens 2398.90 63.04 39 574 P01009 Alpha-1-antitrypsin SERPINA1 Homo sapiens 2181.30 58.61 27 539 Q00610 Clathrin heavy chain 1 CLTC Homo sapiens 2208.17 47.34 53 495 O43707 Alpha-actinin-4 ACTN4 Homo sapiens 2157.22 64.54 43 494 Q01546 Keratin, type II cytoskeletal 2 oral KRT76 Homo sapiens 1104.99 14.73 12 492 P02545 Prelamin-A/C LMNA Homo sapiens 1738.37 54.07 37 473 P19012 Keratin, type I cytoskeletal 15 KRT15 Homo sapiens 1698.59 67.32 28 464 P07355 Annexin A2 ANXA2 Homo sapiens 1886.30 67.55 24 462 P68371 Tubulin beta-4B chain TUBB4B Homo sapiens 2035.19 72.58 23 462 P02751 Fibronectin FN1 Homo sapiens 2046.04 41.74 58 458 P07437 Tubulin beta chain TUBB Homo sapiens 2039.92 72.75 23 455 P00738 Haploglobin HP Homo sapiens 1785.78 61.58 24 453 P01011 Alpha-1-antichymotrypsin SERPINA3 Homo sapiens 1446.96 50.35 18 425 P06576 ATP synthase subunit beta, mitochondrial ATP5B Homo sapiens 1859.52 66.16 23 410 P01857 Ig gamma-1 chain C region IGHG1 Homo sapiens 1887.72 50.61 12 406 P00450 Ceruloplasmin CP Homo sapiens 1918.16 46.29 29 398 P01859 Ig gamma-2 chain C region IGHG2 Homo sapiens 1801.70 51.53 11 392 P51888 Prolargin PRELP Homo sapiens 1226.46 47.12 15 387 P04083 Annexin A1 ANXA1 Homo sapiens 1651.02 64.45 21 382 P04406 Glyceraldehyde-3-phosphate dehydrogenase GAPDH Homo sapiens 1670.21 73.73 17 376 P68363 Tubulin alpha-1B chain TUBA1B Homo sapiens 1568.91 66.96 18 350 Q71U36 Tubulin alpha-1A chain TUBA1A Homo sapiens 1565.01 68.96 18 349 P08779 Keratin, type I cytoskeletal 16 KRT16 Homo sapiens 1255.62 52.64 25 346 Q04695 Keratin, type I cytoskeletal 17 KRT17 Homo sapiens 1278.10 79.63 32 345 P05787 Keratin, type II cytoskeletal 8 KRT8 Homo sapiens 1167.17 48.03 24 342 P21333 Filamin-A FLNA Homo sapiens 1423.87 35.17 54 341 Q13885 Tubulin beta-2A chain TUBB2A Homo sapiens 1387.87 56.40 16 341 Q9BQE3 Tubulin alpha-1C chain TUBA1C Homo sapiens 1498.39 69.27 18 332 P14618 Pyruvate kinase isozymes M1/M2 PKM Homo sapiens 1344.45 68.17 28 328 Q15063 Periostin POSTN Homo sapiens 1387.00 43.54 25 327 P58107 Epiplakin EPPK1 Homo sapiens 1409.85 46.90 45 321 P07585 Decorin DCN Homo sapiens 1226.95 49.30 15 317 P14923 Junction plakoglobin JUP Homo sapiens 1478.56 55.17 28 314 P35609 Alpha-actinin-2 ACTN2 Homo sapiens 1213.25 55.48 38 305 P20774 Mimecan OGN Homo sapiens 1230.96 44.30 13 301 P21810 Biglycan BGN Homo sapiens 1169.94 51.09 14 293 P12814 Alpha-actinin-1 ACTN1 Homo sapiens 1088.32 34.87 27 291 P00488 Coagulation factor XIII A chain F13A1 Homo sapiens 1224.31 40.57 21 291 P08107 Heat shock 70 kDa protein 1A/1B HSPA1A Homo sapiens 1201.31 55.38 25 291 P01876 Ig alpha-1 chain C region IGHA1 Homo sapiens 1328.87 50.42 11 291 P02788 Lactotransferrin LTF Homo sapiens 1000.06 67.61 39 283 P13639 Elongation factor 2 EEF2 Homo sapiens 998.65 37.18 24 79 Q13813 Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Homo sapiens 1389.63 27.71 42 276 P02647 Apolipoprotein A-I APOA1 Homo sapiens 1111.22 70.79 22 274 P01860 Ig gamma-3 chain C region IGHG3 Homo sapiens 1182.07 45.09 11 273 P11142 Heat shock cognate 71 kDa protein HSPA8 Homo sapiens 1142.75 39.16 21 272 P06899 Histone H2B type 1-J HIST1H2BJ Homo sapiens 740.33 40.48 5 271 P68871 Hemoglobin subunit beta HBB Homo sapiens 1083.28 88.44 12 271 P08758 Annexin A5 ANXA5 Homo sapiens 1003.25 56.56 17 268 P11021 78 kDa glucose-regulated protein HSPA5 Homo sapiens 958.13 39.60 22 265 Q15582 Transforming growth factor-beta-induced TGFBI Homo sapiens 996.01 49.19 24 264 protein ig-h3 P69905 Hemoglobin subunit alpha HBA1; Homo sapiens 1419.48 83.80 8 262 P08603 Complement factor H CFH Homo sapiens 966.16 38.67 32 257 P46940 Ras GTPase-activating-like protein IQGAP1 IQGAP1 Homo sapiens 1173.73 26.55 28 253 P06732 Creatine kinase M-type CKM Homo sapiens 997.59 63.78 17 252 P02790 Hemopexin HPX Homo sapiens 1318.29 50.65 14 251 P20908 Collagen alpha-1(V) chain COL5A1 Homo sapiens 159.61 3.97 4 248 P01834 Ig kappa chain C region IGKC Homo sapiens 998.31 80.19 6 243 P06396 Gelsolin GSN Homo sapiens 1156.49 32.99 15 241 P06733 Alpha-enolase ENO1 Homo sapiens 813.18 60.37 18 239 Q02388 Collagen alpha-1(VII) chain COL7A1 Homo sapiens 896.99 17.87 33 238 P55083 Microfibril-associated glycoprotein 4 MFAP4 Homo sapiens 1345.67 44.71 5 236 P51884 Lumican LUM Homo sapiens 756.06 37.87 11 235 P02763 Alpha-1-acid glycoprotein 1 ORM1 Homo sapiens 917.03 44.78 9 233 P01861 Ig gamma-4 chain C region IGHG4 Homo sapiens 988.15 50.76 9 231 P10909 Clusterin CLU Homo sapiens 867.40 29.18 12 226 P04075 Fructose-bisphosphate aldolase A ALDOA Homo sapiens 1022.74 75.55 18 225 P00558 Phosphoglycerate kinase 1 PGK1 Homo sapiens 1016.26 58.03 18 222 P55072 Transitional endoplasmic reticulum ATPase VCP Homo sapiens 935.67 46.77 24 221 Q9BXN1 Asporin ASPN Homo sapiens 876.49 46.05 13 220 P25705 ATP synthase subunit alpha, mitochondrial ATP5A1 Homo sapiens 825.16 46.84 19 219 P04004 Vitronectin VTN Homo sapiens 976.05 37.24 11 219 Q01082 Spectrin beta chain, non-erythrocytic 1 SPTBN1 Homo sapiens 1081.58 25.34 36 213 P09493 Tropomyosin alpha-1 chain TPM1 Homo sapiens 776.98 55.99 23 211 P14625 Endoplasmin HSP90B1 Homo sapiens 887.48 33.00 21 209 P13929 Beta-enolase ENO3 Homo sapiens 760.72 55.99 16 206 P98160 Basement membrane-specific heparan HSPG2 Homo sapiens 872.27 17.29 41 202 sulfate proteoglycan core protein P60174 Triosephosphate isomerase TPI1 Homo sapiens 777.86 65.73 13 197 P01877 Ig alpha-2 chain C region IGHA2 Homo sapiens 1024.76 48.24 9 195 P04792 Heat shock protein beta-1 HSPB1 Homo sapiens 872.68 76.59 12 194 P02144 Myoglobin MB Homo sapiens 881.11 65.58 11 192 P16615 Sarcoplasmic/endoplasmic reticulum calcium ATP2A2 Homo sapiens 728.60 32.63 23 190 ATPase 2 P07900 Heat shock protein HSP 90-alpha HSP90AA1 Homo sapiens 744.33 30.05 18 190 P40939 Trifunctional enzyme subunit alpha, HADHA Homo sapiens 857.52 40.10 17 187 mitochondrial P68104 Elongation factor 1-alpha 1 EEF1A1 Homo sapiens 851.60 40.04 13 186 P07951 Tropomyosin beta chain TPM2 Homo sapiens 648.46 59.86 22 186 P12035 Keratin, type II cytoskeletal 3 KRT3 Homo sapiens 641.16 16.40 14 184 P30101 Protein disulfide-isomerase A3 PDIA3 Homo sapiens 913.05 47.92 19 183 P10809 60 kDa heat shock protein, mitochondrial HSPD1 Homo sapiens 881.81 51.66 21 179 Q9BUF5 Tubulin beta-6 chain TUBB6 Homo sapiens 642.15 48.21 15 178 P23142 Fibulin-1 FBLN1 Homo sapiens 891.96 34.85 17 174 P00338 L-lactate dehydrogenase A chain LDHA Homo sapiens 670.19 57.23 17 171 P04264 Keratin, type II cytoskeletal 1 KRT1 Homo sapiens 591.46 24.38 16 171 Q86VB7 Scavenger receptor cysteine-rich type 1 CD163 Homo sapiens 870.30 29.84 20 168 protein M130 P06753 Tropomyosin alpha-3 chain TPM3 Homo sapiens 616.79 60.56 25 165 P35749 Myosin-11 MYH11 Homo sapiens 691.99 12.12 16 162 P07237 Protein disulfide-isomerase P4HB Homo sapiens 666.06 47.24 19 162 Q99798 Aconitate hydratase mitochondrial ACO2 Homo sapiens 794.47 48.97 22 161 P08238 Heat shock protein HSP 90-beta HSP90AB1 Homo sapiens 587.99 28.31 18 161 P00387 NADH-cytochrome b5 reductase 3 CYB5R3 Homo sapiens 1074.76 57.14 9 161 P40926 Malate dehydrogenase, mitochondrial MDH2 Homo sapiens 588.03 53.55 14 161 P05976 Myosin light chain 1/3, skeletal muscle MYL1 Homo sapiens 690.54 79.90 15 157 isoform P08133 Annexin A6 ANXA6 Homo sapiens 603.14 36.40 18 156 P62805 Histone H4 HIST1H4A Homo sapiens 530.41 53.40 8 155 Q06830 Peroxiredoxin-1 PRDX1 Homo sapiens 888.30 60.80 10 155 P19652 Alpha-1-acid glycoprotein 2 ORM2 Homo sapiens 616.30 39.30 6 154 P67936 Tropomyosin alpha-4 chain TPM4 Homo sapiens 549.57 54.44 17 151 O60437 Periplakin PPL Homo sapiens 650.26 22.38 24 151 Q9NZN4 EH domain-containing protein 2 EHD2 Homo sapiens 772.61 40.15 12 150 Q14764 Major vault protein MVP Homo sapiens 671.11 36.17 20 150 Q92954 Proteoglycan 4 PRG4 Homo sapiens 569.98 7.91 9 150 P04003 C4b-binding protein alpha chain C4BPA Homo sapiens 657.08 43.55 16 149 P00747 Plasminogen PLG Homo sapiens 713.50 41.11 18 149 P04220 Ig mu heavy chain disease protein MUCB Homo sapiens 773.97 38.11 9 148 O14983 Sarcoplasmic/endoplasmic reticulum calcium ATP2A1 Homo sapiens 617.91 34.07 25 145 ATPase 1 P38646 Stress-70 protein, mitochondrial HSPA9 Homo sapiens 602.67 31.81 15 145 P01871 Ig mu chain C region IGHM Homo sapiens 537.31 39.60 13 142 P00352 Retinal dehydrogenase 1 ALDH1A1 Homo sapiens 638.57 46.91 14 141 P27824 Calnexin CANX Homo sapiens 653.49 29.73 11 141 P00739 Haptoglobin-related protein HPR Homo sapiens 534.40 30.17 13 137 Q16555 Dihydropyrimidinase-related protein 2 DPYSL2 Homo sapiens 566.07 42.48 15 133 P08865 40S ribosomal protein SA RPSA Homo sapiens 700.13 45.42 7 133 Q7Z7G0 Target of Nesh-SH3 ABI3BP Homo sapiens 519.78 22.33 15 132 P32926 Desmoglein-3 DSG3 Homo sapiens 524.96 22.72 15 131 P54652 Heat shock-related 70 kDa protein 2 HSP42 Homo sapiens 483.73 15.34 9 130 P09525 Annexin A4 ANXA4 Homo sapiens 478.40 40.13 11 128 P02749 Beta-2-glycoprotein 1 APOH Homo sapiens 514.23 47.25 10 128 P11217 Glycogen phosphorylase, muscle form PYGM Homo sapiens 524.04 36.94 22 125 P19823 Inter-alpha-typsin inhibitor heavy chain H2 ITIH2 Homo sapiens 624.95 22.09 13 125 P13645 Keratin, type I cystoskeletal 10 KRT10 Homo sapiens 411.32 38.36 17 124 P68431 Histone H3.1 HIST1H3A Homo sapiens 549.86 35.29 3 123 P62937 Peptidyl-prolyl cis-trans isomerase A PPIA Homo sapiens 496.09 54.55 7 123 P12236 ADP/ATP translocase 3 SLC25A6 Homo sapiens 396.51 36.58 8 121 P27797 Calreticulin CALR Homo sapiens 526.24 53.96 12 121 Q13642 Four and a half LIM domains protein 1 FHL1 Homo sapiens 453.77 36.22 9 121 P12235 ADP/ATP translocase 1 SLC25A4 Homo sapiens 404.10 43.62 11 126 P19105 Myosin regulatory light chain 12A MYL12A Homo sapiens 444.26 50.88 7 120 P04114 Apolipoprotein B-100 APOB Homo sapiens 581.35 8.81 25 120 P0C0L4 Complement C4-A C4A Homo sapiens 525.25 21.04 20 119 P13611 Versican core protein VCAN Homo sapiens 621.17 6.63 14 119 P07339 Cathepsin D CTSD Homo sapiens 425.52 30.83 10 117 P09211 Glutathione S-transferase P GSTP1 Homo sapiens 559.18 60.48 9 116 Q08043 Alpha-actinin-3 ACTN3 Homo sapiens 412.61 16.98 13 116 Q14624 Inter-alpha-trypsin inhibitor heavy chain H4 ITIH4 Homo sapiens 432.28 26.45 15 116 P08729 Keratin, type II cytoskeletal 7 KRT7 Homo sapiens 350.55 36.46 17 116 P63104 14-3-3 protein zeta/delta YWHAZ Homo sapiens 363.16 43.27 8 115 P06744 Glucose-6-phosphate isomerase GPI Homo sapiens 514.97 39.61 13 115 P02042 Hemoglobin subunit delta HBD Homo sapiens 504.88 57.82 9 114 P07195 L-lactate dehydrogenase B Chain LDHB Homo sapiens 397.81 30.54 11 113 P37802 Transgelin-2 TAGLN2 Homo sapiens 412.88 44.22 7 112 P0CG05 Ig lambda-2 chain C regions IGLC2 Homo sapiens 306.17 74.53 5 112 Q07507 Dermatopontin DPT Homo sapiens 516.65 60.70 7 111 Q14195 Dihydropyrimidinase-retated protein 3 DPYSL3 Homo sapiens 510.80 42.63 14 110 P04844 Dolichyl-diphosphooligosaccharide-protein RPN2 Homo sapiens 515.84 35.18 12 108 glycosyltransferase subunit 2 Q13835 Plakophilin-1 PKP1 Homo sapiens 419.65 26.64 14 107 P04843 Dolichyl-diphosphooligosaccharide-protein RPN1 Homo sapiens 511.79 35.26 14 107 glycosyltransferase subunit 1 P06702 Protein S100-A9 S100A9 Homo sapiens 462.23 74.56 7 107 P08572 Collagen alpha-2(IV) chain COL4A2 Homo sapiens 148.22 7.48 7 105 P61978 Heterogeneous nuclear ribonucleoprotein K HNRNPK Homo sapiens 395.65 25.27 8 101 P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 Homo sapiens 303.86 31.14 12 100 P00367 Glutamate dehydrogenase 1, mitochondrial GLUD1 Homo sapiens 394.06 35.48 14 100 P30086 Phosphatidylethanolamine-binding protein 1 PEBP1 Homo sapiens 565.01 70.59 8 100 P01008 Antithrombin-III SERPINC1 Homo sapiens 418.47 32.54 12 99 P36578 60S ribosomal protein L4 RPL4 Homo sapiens 379.47 32.55 11 99 P24844 Myosin regulatory light polypeptide 9 MYL9 Homo sapiens 404.88 56.40 7 98 P02774 Vitamin D-binding protein GC Homo sapiens 425.10 29.32 10 98 P17661 Desmin DES Homo sapiens 352.16 41.91 19 97 P30048 Thioredoxin-dependent peroxide reductase, PRDX3 Homo sapiens 533.07 48.05 7 97 mitochondrial P31949 Protein S100-A11 S100A11 Homo sapiens 439.33 71.43 6 97 P23528 Cofilin-1 CFL1 Homo sapiens 418.44 63.25 9 96 P04217 Alpha-1B-glycoprotein A1BG Homo sapiens 398.41 38.79 11 96 P35221 Catenin alpha-1 CTNNA1 Homo sapiens 449.17 42.49 20 95 Q12805 EGF-containing fibulin-like extracellular EFEMP1 Homo sapiens 462.35 39.35 12 95 matrix protein 1 P05141 ADP/ATP translocase 2 SLC25A5 Homo sapiens 308.16 27.52 7 95 P17174 Aspartate aminotransferase, cytoplasmic GOT1 Homo sapiens 386.92 52.78 16 94 P63244 Guanine nucleotide-binding protein subunit GNB2L1 Homo sapiens 428.30 52.37 10 94 beta-2-like 1 P05783 Keratin, type I cytoskeletal 18 KRT18 Homo sapiens 313.43 44.42 13 92 P17540 Creatine kinase S-type, mitochondrial CKMT2 Homo sapiens 380.25 49.16 14 92 P60660 Myosin light polypeptide 6 MYL6 Homo sapiens 335.10 52.98 8 92 P22352 Glutathione peroxidase 3 GPX3 Homo sapiens 296.23 29.20 5 92 P62258 14-3-3 protein epsilon YWHAE Homo sapiens 273.86 33.33 8 90 P00751 Complement factor B CFB Homo sapiens 335.25 28.01 14 90 P12532 Creatine kinase U-type, mitochondrial CKMT1A Homo sapiens 451.15 37.17 9 90 Q14315 Filamin-C FLNC Homo sapiens 343.94 13.72 23 90 P39656 Dolichyl-diphosphooligosaccharide-protein DDOST Homo sapiens 642.76 25.22 6 90 glycosyltransferase 48 kDa subunit P40925 Malate dehydrogenase, cytoplasmic MDH1 Homo sapiens 339.35 36.23 9 89 Q00872 Myosin-binding protein C, slow-type MYBPC1 Homo sapiens 320.23 26.29 22 89 P22695 Cytochrome b-c1 complex subunit 2, UQCRC2 Homo sapiens 372.95 36.20 12 89 mitochondrial Q7Z406 Myosin-14 MYH14 Homo sapiens 346.95 5.26 7 89 Q96A32 Myosin regulatory light chain 2, skeletal MYLPF Homo sapiens 301.63 69.82 11 88 muscle isoform P05388 60S acidic ribosomal protein P0 RPLP0 Homo sapiens 281.69 39.43 8 88 Q05639 Elongation factor 1-alpha 2 EEF1A2 Homo sapiens 402.16 30.67 9 87 P98095 Fibulin-2 FBLN2 Homo sapiens 355.37 22.97 16 87 P00568 Adenylate kinase isoenzyme 1 AK1 Homo sapiens 457.63 46.91 7 86 P61626 Lysozyme C LYZ Homo sapiens 396.57 46.62 5 86 P18669 Phosphoglycerate mutase 1 PGAM1 Homo sapiens 367.15 59.84 11 86 P62917 60S ribosomal protein L8 RPL8 Homo sapiens 397.44 36.96 6 86 Q14204 Cytoplasmic dynein 1 heavy chain 1 DYNC1H1 Homo sapiens 405.37 7.25 19 85 P29401 Transketolase TKT Homo sapiens 482.56 31.94 9 85 P02750 Leucine-rich alpha-2-glycoprotein LRG1 Homo sapiens 377.99 41.50 9 84 P21980 Protein-glutamine gamma- TGM2 Homo sapiens 357.31 30.57 13 84 glutamyltransferase 2 P18206 Vinculin VCL Homo sapiens 289.28 23.46 17 84 P61981 14-3-3 protein gamma YWHAG Homo sapiens 329.88 42.51 7 83 P21964 Catechol O-methyltransferase COMT Homo sapiens 392.61 52.40 9 83 P62424 60S ribosomal protein L7a RPL7A Homo sapiens 299.36 35.34 10 83 P0DJI8 Serum amyloid A-1 protein SAA1 Homo sapiens 370.93 66.39 7 83 P05023 Sodium/potassium-transporting ATPase ATP1A1 Homo sapiens 290.15 17.69 13 81 subunit alpha-1 P62158 Calmodulin CALM1 Homo sapiens 307.86 46.98 7 81 P55084 Trifunctional enzyme subunit beta, HADHB Homo sapiens 360.39 39.03 11 81 mitochondrial Q14697 Neutral alpha-glucosidase AB GANAB Homo sapiens 415.60 25.00 12 81 P62879 Guanine nucleotide-binding protein GNB2 Homo sapiens 308.38 52.35 11 81 G(I)/G(S)/G(T) subunit beta-2 P07858 Cathepsin B CTSB Homo sapiens 379.84 27.73 7 80 P06748 Nucleophosmin NPM1 Homo sapiens 408.27 24.15 5 80 P05155 Plasma protease C1 inhibitor SERPING1 Homo sapiens 295.14 22.40 10 79 Q15084 Protein disulfide-isomerase A6 PDIA6 Homo sapiens 302.05 33.41 9 79 P24821 Tenascin TNC Homo sapiens 328.11 16.13 19 79 P31947 14-3-3 protein sigma SFN Homo sapiens 358.29 55.65 10 78 Q03135 Caveolin-1 CAV1 Homo sapiens 368.92 46.63 6 78 P35222 Catenin beta-1 CTNNB1 Homo sapiens 428.51 16.77 8 78 P26038 Moesin MSN Homo sapiens 287.39 24.09 11 78 P22897 Macrophage mannose receptor 1 MRC1 Homo sapiens 357.42 15.87 14 78 Q15365 Poly(rC)-binding protein 1 PCBP1 Homo sapiens 349.30 32.02 7 78 P11216 Glycogen phosphorylase, brain form PYGB Homo sapiens 311.63 22.18 13 78 P21796 Voltage-dependent anion-selective channel VDAC1 Homo sapiens 295.47 51.24 9 77 protein 1 P27348 14-3-3 protein theta YWHAQ Homo sapiens 238.77 38.78 8 76 P45378 Troponin T, fast skeletal muscle TNNT3 Homo sapiens 371.79 36.80 11 76 Q92928 Putative Ras-related protein Rab-1C RAB1C Homo sapiens 204.29 31.34 5 76 P52895 Aldo-keto reductase family 1 member C2 AKR1C2 Homo sapiens 370.32 36.53 7 75 P02792 Fernitin light chain FTL Homo sapiens 374.53 44.57 6 74 P27105 Erythrocyte band 7 integral membrane STOM Homo sapiens 355.48 39.24 6 74 protein P61204 ADP-ribosylation factor 3 ARF3 Homo sapiens 264.46 54.70 8 73 P63241 Eukaryotic translation initiation factor 5A-1 EIF5A Homo sapiens 402.91 61.69 7 73 Q8TDL5 BPI fold-containing family B member 1 BPIFB1 Homo sapiens 280.43 39.88 13 73 P35232 Prohibitin PHB Homo sapiens 392.68 47.06 7 73 P00505 Aspartate aminotransferase, mitochondrial GOT2 Homo sapiens 322.70 40.00 11 73 P17931 Galectin-3 LGALS3 Homo sapiens 276.89 28.40 6 73 O95994 Anterior gradient protein 2 homolog AGR2 Homo sapiens 266.91 54.86 6 72 P26641 Elongation factor 1-gamma EEF1G Homo sapiens 241.88 26.32 8 71 P23396 40S ribosomal protein S3 RPS3 Homo sapiens 262.77 50.62 10 71 P45880 Voltage-dependent anion-selective channel VDAC2 Homo sapiens 309.07 38.78 8 71 prolein 2 Q08211 ATP-dependent RNA helicase A DHX9 Homo sapiens 350.79 11.97 9 70 P05387 60S acidic ribosomal protein P2 RPLP2 Homo sapiens 308.01 85.22 6 70 P31946 14-3-3 protein beta/alpha YWHAB Homo sapiens 223.98 34.55 7 69 P09972 Fructose-bisphosphate aldolase C ALDOC Homo sapiens 307.69 20.33 5 69 P30740 Leukocyte elastase inhibitor SERPINB1 Homo sapiens 297.65 34.83 8 69 P39023 60S ribosomal protein L3 RPL3 Homo sapiens 308.88 26.30 8 69 P62081 40S ribosomal protein S7 RPS7 Homo sapiens 329.43 37.11 4 69 Q01469 Fatty acid-binding protein, epidermal FABP5 Homo sapiens 304.75 41.48 5 68 P15259 Phosphoglycerate mutase 2 PGAM2 Homo sapiens 295.35 56.92 12 68 P30041 Peroxiredoxin-6 PRDX6 Homo sapiens 299.12 37.05 6 68 P52209 6-phosphogluconate dehydrogenase, PGD Homo sapiens 348.83 19.25 6 67 decarboxylating P31040 Succinate dehydrogenase [ubiquinone] SDHA Homo sapiens 321.54 20.93 9 67 flavoprotein subunit, mitochondrial P07099 Epoxide hydrolase 1 EPHX1 Homo sapiens 330.10 32.75 7 67 P22626 Heterogeneous nuclear ribonucleoproteins HNRNPA2B1 Homo sapiens 239.94 25.78 9 67 A2/B1 P62701 40S ribosomal protein S4, X isoform RPS4X Homo sapiens 227.75 41.44 10 67 P07384 Calpain-1 catalytic subunit CAPN1 Homo sapiens 258.35 26.47 11 66 P99999 Cytochrome c CYCS Homo sapiens 241.24 48.57 5 66 Q16777 Histone H2A type 2-C HIST2H2AC Homo sapiens 184.31 63.57 6 66 P52272 Heterogeneous nuclear ribonucleoprotein M HNRNPM Homo sapiens 236.69 21.51 12 66 P60842 Eukaryotic initiation factor 4A-I EIF4A1 Homo sapiens 210.21 41.38 12 66 P10916 Myosin regulatory light chain 2, MYL2 Homo sapiens 242.44 77.71 10 66 ventricular/cardiac muscle isoform Q6NZI2 Polymerase I and transcript release factor PTRF Homo sapiens 253.00 22.56 7 66 P29508 Serpin B3 SERPINB3 Homo sapiens 230.90 37.44 11 66 Q9Y490 Talin-1 TLN1 Homo sapiens 245.23 11.26 15 66 P39060 Collagen alpha-1(XVIII) chain COL18A1 Homo sapiens 311.69 7.58 6 66 Q13361 Microfibrillar-associated protein 5 MFAP5 Homo sapiens 229.94 18.50 3 65 P32119 Peroxiredoxin-2 PRDX2 Homo sapiens 302.38 32.32 6 65 P01042 Kininogen-1 KNG1 Homo sapiens 254.20 21.89 9 64 P13489 Ribonuclease inhibitor RNH1 Homo sapiens 294.50 31.67 8 64 Q9HCY8 Protein S100-A414 S100A14 Homo sapiens 240.31 65.38 5 64 P04179 Superoxide dismutase [Mn], mitochondrial SOD2 Homo sapiens 285.33 61.71 7 64 O75390 Citrate synthase, mitochondrial CS Homo sapiens 348.67 30.26 8 63 P08294 Extracellular superoxide dismutase [CuZn] SOD3 Homo sapiens 255.58 26.67 5 63 Q15661 Tryptase alpha/beta-1 TPSAB1 Homo sapiens 232.08 22.18 6 63 Q9Y277 Voltage-dependent anion-selective channel VDAC3 Homo sapiens 225.78 27.21 5 63 protein 3 P00403 Cytochrome c oxidase subunit 2 MT-CO2 Homo sapiens 210.74 20.26 3 62 P49411 Elongation factor Tu, mitochondrial TUFM Homo sapiens 266.69 25.00 8 62 P26599 Polypyrimidine tract-binding protein 1 PTBP1 Homo sapiens 332.59 32.20 9 62 P09382 Galectin-1 LGALS1 Homo sapiens 210.45 65.93 6 61 P00734 Prothrombin F2 Homo sapiens 251.04 30.23 12 61 P31415 Calsequestrin-1 CASQ1 Homo sapiens 318.32 29.29 7 61 P25311 Zinc-alpha-2-glycoprotein AZGP1 Homo sapiens 254.10 29.53 6 61 P48735 Isocitrate dehydrogenase [NADP], IDH2 Homo sapiens 207.55 27.65 11 60 mitochondrial P09622 Dihydrolipoyl dehydrogenase, mitochondrial DLD Homo sapiens 333.83 20.24 6 60 Q6DD88 Atlastin-3 ATL3 Homo sapiens 348.75 32.72 8 59 P13010 X-ray repair cross-complementing protein 5 XRCC5 Homo sapiens 310.59 25.55 10 59 P22392 Nucleoside diphosphate kinase B NME2 Homo sapiens 226.78 35.53 4 59 P27635 60S ribosomal protein L10 RPL10 Homo sapiens 253.21 36.92 8 59 P30153 Serine/threonine-protein phosphatase 2A 65 kDa PPP2R1A Homo sapiens 245.66 14.09 5 58 regulatory subunit A alpha isoform P18085 ADP-ribosylation factor 4 ARP4 Homo sapiens 200.39 48.33 7 58 O43852 Calumenin CALU Homo sapiens 344.28 36.19 6 58 Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 Homo sapiens 256.09 44.83 7 58 P47929 Galectin-7 LGALS7 Homo sapiens 267.04 55.15 5 58 P50914 60S ribosomal protein L14 RPL14 Homo sapiens 164.83 24.19 5 58 P04080 Cystatin-B CSTB Homo sapiens 255.39 45.92 3 57 P12277 Creatine kinase B-type CKB Homo sapiens 243.55 38.85 9 57 P08590 Myosin light chain 3 MYL3 Homo sapiens 180.14 47.69 8 57 P15880 40S ribosomal protein S2 RPS2 Homo sapiens 247.88 25.94 5 57 P50454 Serpin H1 SERPINH1 Homo sapiens 255.28 42.11 12 57 Q96TA1 Niban-like protein 1 FAM129B Homo sapiens 273.85 13.40 6 57 P48047 ATP synthase subunit O, mitochondrial ATP5O Homo sapiens 198.34 44.60 6 56 P07954 Fumarate hydratase, mitochondrial FH Homo sapiens 315.14 24.12 5 56 Q99623 Prohibitin-2 PHB2 Homo sapiens 201.31 37.12 8 56 P02743 Serum amyloid P-component APCS Homo sapiens 175.11 25.11 6 56 P20929 Nebulin NEB Homo sapiens 181.95 5.88 21 56 P62979 Ubiquitin-40S ribosomal protein S27a RPS27A Homo sapiens 194.01 28.21 3 56 P07910 Heterogeneous nuclear ribonucleoproteins HNRNPC Homo sapiens 178.69 20.92 7 55 C1/C2 P50995 Annexin A11 ANXA11 Homo sapiens 193.16 21.98 9 54 P02649 Apolipoprotein E APOE Homo sapiens 205.73 31.55 7 54 P04632 Calpain small subunit 1 CAPNS1 Homo sapiens 267.00 30.97 4 54 O75367 Core histone macro-H2A.1 H2AFY Homo sapiens 224.12 29.03 7 54 Q32P51 Heterogeneous nuclear ribonucleoprotein A1- HNRNPA1L2 Homo sapiens 198.73 23.13 7 54 like 2 P16403 Histone H1.2 HIST1H1C Homo sapiens 158.83 20.19 7 53 Q9NZM1 Myoferlin MYOF Homo sapiens 225.43 8.98 11 53 P05109 Protein S100-A8 S100A8 Homo sapiens 162.26 40.86 4 53 Q14134 Tripartite motif-containing protein 29 TRIM29 Homo sapiens 210.80 21.43 9 53 P35443 Thrombospondin-4 THBS4 Homo sapiens 243.36 25.39 13 53 Q05707 Collagen alpha-1(XIV) chain COL14A1 Homo sapiens 231.55 8.35 11 52 Q99497 Protein DJ-1 PARK7 Homo sapiens 236.62 56.61 6 52 Q13838 Spliceosome RNA helicase DDX39B DDX39B Homo sapiens 210.91 18.93 5 52 P35527 Keratin, type I cytoskeletal 9 KRT9 Homo sapiens 258.81 18.94 7 51 O94973 AP-2 complex subunit alpha-2 AP2A2 Homo sapiens 229.57 14.91 7 51 Q14574 Desmocollin-3 DSC3 Homo sapiens 284.04 16.52 8 51 P04899 Guanine nucleotide-binding protein G(i) GNAI2 Homo sapiens 181.43 32.39 8 51 subunit alpha-2 P0C0S5 Histone H2A.Z H2AFZ Homo sapiens 157.41 42.97 4 51 P46777 60S ribosomal protein L5 RPL5 Homo sapiens 211.39 23.57 5 51 P05386 60S acidic ribosomal protein P1 RPLP1 Homo sapiens 201.61 66.67 3 51 O75083 WD repeat-containing protein 1 WDR1 Homo sapiens 312.47 33.00 9 51 Q02218 2-oxoglutarate dehydrogenase, mitochondrial OGDH Homo sapiens 284.56 18.18 9 51 P60033 CD81 antigen CD81 Homo sapiens 232.36 25.00 3 50 P09429 High mobility group protein B1 HMGB1 Homo sapiens 221.28 27.91 5 50 P30838 Aldehyde dehydrogenase, dimeric NADP- ALDH3A1 Homo sapiens 188.52 29.36 7 50 preferring P16152 Carbonyl reductase [NADPH] 1 CBR1 Homo sapiens 205.13 53.07 11 49 P46782 40S ribosomal protein S5 RPS5 Homo sapiens 160.59 33.33 6 49 P01880 Ig delta chain C region IGHD Homo sapiens 265.21 32.29 7 49 P23284 Peptidyl-prolyl cis-trans isomerase B PPIB Homo sapiens 154.36 43.52 9 49 P61158 Actin-related protein 3 ACTR3 Homo sapiens 229.45 20.10 4 48 P01620 Ig kappa chain V-III region SIE KV302 Homo sapiens 210.50 39.45 3 48 Q9H8H3 Methyltransferase-like protein 7A METTL7A Homo sapiens 172.04 31.56 5 48 Q9NQC3 Reticulon-4 RTN4 Homo sapiens 230.34 7.30 5 48 Q9Y3Z3 SAM domain and HD domain-containing SAMHD1 Homo sapiens 215.44 23.32 9 48 protein 1 P54296 Myomesin-2 MYOM2 Homo sapiens 209.59 18.09 13 48 P21926 CD9 antigen CD9 Homo sapiens 267.46 15.35 2 47 P43490 Nicotinamide phosphoribosyltransferase NAMPT Homo sapiens 265.35 33.20 9 47 P48788 Troponin I, fast skeletal muscle TNNI2 Homo sapiens 247.76 42.86 8 47 P17655 Calpain-2 catalytic subunit CAPN2 Homo sapiens 228.83 20.57 7 47 Q00839 Heterogeneous nuclear ribonucleoprotein U HNRNPU Homo sapiens 201.33 12.36 5 47 Q02878 60S ribosomal protein L6 RPL6 Homo sapiens 164.14 26.39 7 46 P25398 40S ribosomal protein S12 RPS12 Homo sapiens 204.42 47.73 5 46 A6NMZ7 Collagen alpha-6(VI) chain COL6A6 Homo sapiens 223.43 9.72 13 46 Q92817 Envoplakin EVPL Homo sapiens 238.79 11.95 13 46 P62263 40S ribosomal protein S14 RPS14 Homo sapiens 191.81 63.58 5 45 P62241 40S ribosomal protein S8 RPS8 Homo sapiens 158.52 34.62 6 45 P43304 Glycerol-3-phosphate dehydrogenase, GPD2 Homo sapiens 237.37 13.76 5 45 mitochondrial P15121 Aldose reductase AKR1B1 Homo sapiens 205.46 27.22 5 44 P02747 Complement C1q subcomponent subunit C C1QC Homo sapiens 149.99 25.31 5 44 P02748 Complement component C9 C9 Homo sapiens 175.08 13.60 6 44 P24534 Elongation factor 1-beta EEF1B2 Homo sapiens 185.03 34.67 4 44 Q07020 60S ribosomal protein L18 RPL18 Homo sapiens 144.36 25.00 4 44 P61247 40S ribosomal protein S3a RPS3A Homo sapiens 176.21 21.59 4 44 P00441 Superoxide dismutase [CuZn] SOD1 Homo sapiens 360.54 53.90 3 44 Q01995 Transgelin TAGLN Homo sapiens 133.46 31.34 5 44 O75369 Filamin-B FLNB Homo sapiens 153.21 4.96 8 44 P26022 Pentraxin-related protein PTX3 PTX3 Homo sapiens 169.22 22.57 7 44 P09758 Tumor-associated calcium signal transducer 2 TACSTD2 Homo sapiens 189.68 32.82 7 44 Q6Y2Q3 Glutathione S-transferase kappa 1 GSTK1 Homo sapiens 190.62 32.74 5 43 Q00325 Phosphate carrier protein, mitochondrial SLC25A3 Homo sapiens 152.13 19.06 5 43 Q06323 Proteasome activator complex subunit 1 PSME1 Homo sapiens 162.04 23.29 5 43 Q16647 Prostacyclin synthase PTGIS Homo sapiens 161.75 33.60 11 43 P29034 Protein S100-A2 S100A2 Homo sapiens 137.60 27.55 4 43 Q9Y6N5 Sulfide:quinone oxidoreductase, SQRDL Homo sapiens 157.67 23.78 8 43 mitochondrial P78371 T-complex protein 1 subunit beta CCT2 Homo sapiens 204.85 25.05 8 43 P22314 Ubiquitin-like modifier-activating enzyme 1 UBA1 Homo sapiens 159.50 12.00 8 43 Q04917 14-3-3 protein eta YWHAH Homo sapiens 123.80 18.29 4 42 P05997 Collagen alpha-2(V) chain COL5A2 Homo sapiens 51.56 4.47 4 42 P00390 Glutathione reductase, mitochondrial GSR Homo sapiens 187.41 23.18 6 42 P52597 Heterogeneous nuclear ribonucleoprotein F HNRNPF Homo sapiens 194.08 21.69 5 42 P18428 Lipopolysaccharide-binding protein LBP Homo sapiens 191.95 14.76 5 42 P12273 Prolactin-inducible protein PIP Homo sapiens 165.44 39.04 4 42 P07737 Profilin-1 PFN1 Homo sapiens 121.34 53.57 6 42 Q15286 Ras-related protein Rab-35 RAB35 Homo sapiens 116.52 19.90 3 42 Q07960 Rho GTPase-activating protein 1 ARHGAP1 Homo sapiens 185.83 24.60 5 42 P62888 60S ribosomal protein L30 RPL30 Homo sapiens 156.93 51.30 4 42 P31930 Cytochrome b-c1 complex subunit 1, UQCRC1 Homo sapiens 194.33 30.00 8 42 mitochondrial P02746 Complement C1q subcomponent subunit B C1QB Homo sapiens 151.74 20.55 4 42 P49748 Very long-chain specific acyl-CoA ACADVL Homo sapiens 188.16 17.10 7 41 dehydrogenase, mitochondrial P56134 ATP synthase subunit f, mitochondrial ATP5J2 Homo sapiens 128.69 25.53 2 41 O14880 Microsomal glutathione S-transferase 3 MGST3 Homo sapiens 209.57 33.55 3 41 P61106 Ras-related protein Rab-14 RAB14 Homo sapiens 139.72 33.02 4 41 P32969 60S ribosomal protein L9 RPL9 Homo sapiens 206.78 50.52 7 41 Q01518 Adenylyl cyclase-associated protein 1 CAP1 Homo sapiens 116.36 18.11 6 41 P0DJI9 Serum amyloid A-2 protein SAA2 Homo sapiens 152.96 47.54 5 41 P02760 Protein AMBP AMBP Homo sapiens 130.27 20.17 5 40 O00571 ATP-dependent RNA helicase DDX3X DDX3X Homo sapiens 136.76 14.80 7 40 P04196 Histidine-rich glycoprotein HRG Homo sapiens 146.71 23.24 8 40 P19338 Nucleolin NCL Homo sapiens 118.67 17.89 8 40 P62826 GTP-binding nuclear protein Ran RAN Homo sapiens 140.71 29.63 5 40 P30050 60S ribosomal protein L12 RPL12 Homo sapiens 142.78 54.55 6 40 Q16851 UTP--glucose-1-phosphate UGP2 Homo sapiens 180.79 24.02 8 40 uridylyltransferase P30044 Peroxiredoxin-5, mitochondrial PRDX5 Homo sapiens 134.47 39.25 6 40 P15144 Aminopeptidase N ANPEP Homo sapiens 199.99 10.44 5 39 Q9Y281 Cofilin-2 CFL2 Homo sapiens 145.82 43.98 5 39 P14854 Cytochrome c oxidase subunit 6B1 COX6B1 Homo sapiens 138.41 56.98 4 39 Q14974 Importin subunit beta-1 KPNB1 Homo sapiens 167.13 10.96 6 39 P18621 60S ribosomal protein L17 RPL17 Homo sapiens 170.36 37.50 6 39 P62829 60S ribosomal protein L23 RPL23 Homo sapiens 159.78 25.00 2 39 P46783 40S ribosomal protein S10 RPS10 Homo sapiens 125.03 23.64 3 39 Q15019 Septin-2 41884 Homo sapiens 201.93 22.44 5 39 Q9BTV4 Transmembrane protein 43 TMEM43 Homo sapiens 256.33 26.25 5 39 P02585 Troponin C, skeletal muscle TNNC2 Homo sapiens 160.86 56.25 6 39 P08574 Cytochrome c1, heme protein, mitochondrial CYC1 Homo sapiens 176.16 20.00 4 39 P36957 Dihydrolipoyllysine-residue DLST Homo sapiens 118.88 16.56 6 39 succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial P08697 Alpha-2-antiplasmin SERPINF2 Homo sapiens 212.46 16.50 4 38 P31943 Heterogeneous nuclear ribonucleoprotein H HNRNPH1 Homo sapiens 143.80 16.26 5 38 P19827 Inter-alpha-trypsin inhibitor heavy chain H1 ITIH1 Homo sapiens 172.16 9.22 5 38 P12956 X-ray repair cross-complementing protein 6 XRCC6 Homo sapiens 128.28 18.06 8 38 P01617 Ig kappa chain V-II region TEW KV204 Homo sapiens 147.26 32.74 2 38 P20700 Lamin-B1 LMNB1 Homo sapiens 115.63 22.01 10 38 P53621 Coatomer subunit alpha COPA Homo sapiens 177.86 10.05 6 38 P20674 Cytochrome c oxidase subunit 5A, COX5A Homo sapiens 152.37 48.00 6 38 mitochondrial Q16891 Mitochondrial inner membrane, protein IMMT Homo sapiens 196.93 13.98 6 37 P62906 60S ribosomal protein L10a RPL10A Homo sapiens 151.26 31.80 6 37 P35268 60S ribosomal protein L22 RPL22 Homo sapiens 208.22 39.06 3 37 P46781 40S ribosomol protein S9 RPS9 Homo sapiens 93.51 29.38 6 37 P49368 T-complex protein 1 subunit gamma CCT3 Homo sapiens 139.77 24.95 9 37 P13805 Troponin T, slow skeletal muscle TNNT1 Homo sapiens 178.15 26.62 6 37 O14773 Tripeptidyl-peptidase 1 TPP1 Homo sapiens 175.66 19.72 5 37 P15088 Mast cell carboxypeptidase A CPA3 Homo sapiens 100.59 16.31 6 37 P21397 Amine oxidase [flavin-containing] A MAOA Homo sapiens 210.61 23.34 7 36 O00264 Membrane-associated progesterone receptor PGRMC1 Homo sapiens 230.02 26.15 2 36 component 1 P62841 40S ribosomal protein S15 RPS15 Homo sapiens 217.34 60.69 5 36 P62847 40S ribosomal protein S24 RPS24 Homo sapiens 114.91 28.57 3 36 Q99832 T-complex protein 1 subunit eta CCT7 Homo sapiens 174.83 16.21 5 36 P02756 Transthyretin TTR Homo sapiens 198.08 58.50 5 36 P50395 Rab GDP dissociation inhibitor beta GDI2 Homo sapiens 184.88 29.21 7 35 Q15366 Poly(rC)-binding protein 2 PCBP2 Homo sapiens 124.46 28.77 6 35 P36871 Phosphoglucomutase-1 PGM1 Homo sapiens 117.76 26.51 9 35 P60953 Cell division control protein 42 homolog CDC42 Homo sapiens 132.02 40.31 5 35 Q03252 Lamin-B2 LMNB2 Homo sapiens 99.19 16.67 8 34 O00151 PDZ and LIM domain protein 1 PDLIM1 Homo sapiens 219.59 20.97 3 34 P61313 60S ribosomal protein L15 RPL15 Homo sapiens 116.87 24.02 4 34 P63010 AP-2 complex subunit beta AP2B1 Homo sapiens 144.72 8.96 4 33 P52907 F-actin-capping protein subunit alpha-1 CAPZA1 Homo sapiens 118.74 22.38 4 33 O00299 Chloride intracellular channel protein 1 CLIC1 Homo sapiens 100.54 24.90 5 33 P59665 Neutrophil defensin 1 DEFA1 Homo sapiens 99.41 20.21 3 33 P30084 Enoyl-CoA hydratase, mitochondrial ECHS1 Homo sapiens 110.92 16.21 3 33 P02794 Femtin heavy chain FTH1 Homo sapiens 190.73 38.80 4 33 P31150 Rab GDP dissociation inhibitor alpha GDI1 Homo sapiens 177.37 19.91 4 33 O43390 Heterogeneous nuclear ribonucleoprotein R HNRNPR Homo sapiens 123.66 11.22 6 33 P28331 NADH-ubiquinone oxidoreductase 75 kDa NDUFS1 Homo sapiens 146.80 14.86 6 33 subunit, mitochondrial P62140 Serine/threonine-protein phosphatase PP1- PPP1CB Homo sapiens 144.77 25.69 5 33 beta catalytic subunit P08134 Rho-related GTP-binding protein RhoC RHOC Homo sapiens 113.02 36.27 4 33 Q96FQ6 Protein S100-A16 S100A16 Homo sapiens 111.92 63.11 5 33 Q10567 AP-1 complex subunit beta-1 AP1B1 Homo sapiens 155.87 4.95 3 33 P51648 Fatty aldehyde dehydrogenase ALDH3A2 Homo sapiens 101.08 11.34 4 32 P61769 Beta-2-microglobulin B2M Homo sapiens 129.55 35.29 3 32 P30042 ES1 protein homolog, mitochondrial C21orf33 Homo sapiens 184.38 26.87 3 32 Q14103 Heterogeneous nuclear ribonucleoprotein D0 HNRNPD Homo sapiens 96.00 19.72 5 32 P46778 60S ribosomal protein L21 RPL21 Homo sapiens 112.78 31.87 4 32 P62910 60S ribosomal protein L32 RPL32 Homo sapiens 102.48 27.41 3 32 P18124 60S ribosomal protein L7 RPL7 Homo sapiens 123.75 34.27 7 32 P51991 Heterogeneous nuclear ribonucleoprotein A3 HNRNPA3 Homo sapiens 118.23 18.52 6 32 P62249 40S ribosomal protein S16 RPS16 Homo sapiens 92.94 30.14 4 32 P62269 40S ribosomal protein S18 RPS18 Homo sapiens 82.25 36.84 6 32 Q8NBS9 Thioredoxin domain-containing protein 5 TXNDC5 Homo sapiens 190.89 16.90 5 32 P55268 Laminin subunit beta-2 LAMB2 Homo sapiens 137.11 7.79 7 32 P07108 Acyl-CoA-binding protein DBI Homo sapiens 158.66 41.38 2 31 Q96KP4 Cytosolic non-specific dipeptidase CNDP2 Homo sapiens 124.80 17.05 5 31 P02511 Alpha-crystallin B chain CRYAB Homo sapiens 115.45 34.29 5 31 P49773 Histidine triad nucleotide-binding protein 1 HINT1 Homo sapiens 238.93 54.76 3 31 Q15181 Inorganic pyrophosphatase PPA1 Homo sapiens 106.49 28.72 5 31 P83731 60S ribosomal protein L24 RPL24 Homo sapiens 103.39 19.11 3 31 Q53EL6 Programmed cell death protein 4 PDCD4 Homo sapiens 151.18 11.73 3 31 P29692 Elongation factor 1-delta EEF1D Homo sapiens 121.20 21.71 4 30 P01625 Ig kappa chain V-IV region Len KV402 Homo sapiens 123.28 23.68 2 30 P55558 Phospholipid transfer protein PLTP Homo sapiens 118.29 16.63 5 30 P51148 Ras-related protein Rab-5C RAB5C Homo sapiens 88.46 18.06 3 30 Q02543 60S ribosomal protein L18a RPL18A Homo sapiens 82.92 25.00 4 30 P0CW22 40S ribosomal protein S17-like RPS17L Homo sapiens 84.85 49.63 4 30 P39019 40S ribosomal protein S19 RPS19 Homo sapiens 93.93 43.45 7 30 P24752 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 Homo sapiens 102.46 16.63 5 30 P36955 Pigment epithelium-derived factor SERPINF1 Homo sapiens 123.08 27.03 6 30 P28838 Cytosol aminopeptidase LAP3 Homo sapiens 128.37 16.18 5 29 P00395 Cytochrome c oxidase subunit 1 MT-CO1 Homo sapiens 114.84 7.60 2 29 P10915 Hyaluronan and proteoglycan link protein 1 HAPLN1 Homo sapiens 128.51 36.16 7 29 O75112 LIM domain-binding protein 3 LDB3 Homo sapiens 159.55 12.38 6 29 O14210 Lymphocyte antigen 6D LY6D Homo sapiens 85.31 16.41 2 29 Q13162 Peroxiredoxin-4 PRDX4 Homo sapiens 110.59 26.57 5 29 P51149 Ras-related protein Rab-7a RAB7A Homo sapiens 91.57 46.38 7 29 Q13228 Selenium-binding protein 1 SELENBP1 Homo sapiens 140.38 25.21 7 29 P23246 Splicing factor, proline- and glutamine-rich SFPQ Homo sapiens 146.88 6.79 3 29 P03973 Antileukoproteinase SLPI Homo sapiens 105.65 20.45 2 29 P49755 Transmembrane emp24 domain-containing TMED10 Homo sapiens 95.34 18.26 4 29 protein 10 P07919 Cytochrome b-c1 complex subunit 6, UQCRH Homo sapiens 151.77 29.67 2 29 mitochondrial P00325 Alcohol dehydrogenase 1B ADH1B Homo sapiens 143.26 15.73 5 28 P07451 Carbonic anhydrase 3 CA3 Homo sapiens 103.24 45.77 7 28 P08311 Cathepsin G CTSG Homo sapiens 86.82 18.43 4 28 P23946 Chymase CMA1 Homo sapiens 104.09 38.87 7 28 P15311 Ezrin EZR Homo sapiens 94.52 10.41 5 28 P08237 6-phosphofructokinase, muscle type PFKM Homo sapiens 103.32 22.82 10 28 Q96AG4 Leucine-rich repeat-containing protein 59 LRRC59 Homo sapiens 102.16 16.61 4 28 P11177 Pyruvate dehydrogenase E1 component PDHB Homo sapiens 107.90 25.35 6 28 subunit beta, mitochondrial Q687X5 Metalloreductase STEAP4 STEAP4 Homo sapiens 127.59 20.26 6 28 P10599 Thioredoxin TXN Homo sapiens 101.16 48.57 4 28 P13928 Annexin A8 ANXA8 Homo sapiens 98.25 28.44 6 28 O00159 Unconventional myosin-Ic MYO1C Homo sapiens 129.53 5.36 3 28 Q9UL46 Proteasome activator complex subunit 2 PSME2 Homo sapiens 132.41 19.67 3 28 O15143 Actin-related protein 2/3 complex subunit 1B ARPC1B Homo sapiens 148.32 13.71 3 27 Q9BRX8 Redox-regulatory protein FAM213A FAM213A Homo sapiens 72.57 16.59 3 27 O60716 Catenin delta-1 CTNND1 Homo sapiens 99.36 10.95 8 27 Q9UBI6 Guanine, nucleotide-binding protein GNG12 Homo sapiens 104.99 56.94 3 27 G(I)/G(S)/G(O) subunit gamma-12 P62899 60S ribosomal protein L31 RPL31 Homo sapiens 72.73 18.40 2 27 P62277 40S ribosomal protein S13 RPS13 Homo sapiens 103.45 25.17 4 27 Q7KZF4 Staphylococcal nuclease domain-containing SND1 Homo sapiens 148.87 15.60 6 27 protein 1 P50990 T-complex protein 1 subunit theta CCT8 Homo sapiens 82.21 14.42 6 27 Q53GQ0 Estradiol 17-beta-dehydrogenase 12 HSD17B12 Homo sapiens 109.00 26.60 6 27 P10316 HLA class I histocompatibility antigen, A-69 HLA-A Homo sapiens 102.31 29.32 7 26 alpha chain P30481 HLA class I histocompatibility antigen, B-44 HLA-B Homo sapiens 106.48 19.89 5 20 alpha chain P05090 Apolipoprotein D APOD Homo sapiens 79.01 24.34 5 26 P00918 Carbonic anhydrase 2 CA2 Homo sapiens 94.23 23.85 4 26 P17858 6-phosphofructokinase, liver type PFKL Homo sapiens 110.94 13.33 5 26 P01598 Ig kappa chain V-I region EU KV106 Homo sapiens 111.02 26.85 2 26 P08559 Pyruvate dehydrogenase E1 component PDHA1 Homo sapiens 133.81 18.46 4 26 subunit alpha, somatic form, mitochondrial P78527 DNA-dependent protein kinase catalytic PRKDC Homo sapiens 124.68 3.83 8 26 subunit Q86TD4 Sarcalumenin SRL Homo sapiens 88.38 7.30 6 26 Q15185 Prostaglandin E synthase 3 PTGES3 Homo sapiens 94.89 18.13 2 26 P16070 CD44 antigen CD44 Homo sapiens 99.10 6.87 4 26 P54709 Sodium/potassium-transporting ATPase ATP1B3 Homo sapiens 104.69 17.20 3 25 subunit beta-3 O94905 Erlin-2 ERLIN2 Homo sapiens 77.46 17.99 4 25 Q9BSJ8 Extended synaptotagmin-1 ESYT1 Homo sapiens 90.36 5.89 4 25 Q92597 Protein NDRG1 NDRG1 Homo sapiens 119.80 22.34 5 25 Q9UQ80 Proliferation-associated protein 2G4 PA2G4 Homo sapiens 91.68 17.51 4 25 P42766 60S ribosomal protein L35 RPL35 Homo sapiens 91.31 23.58 3 25 P54920 Alpha-soluble NSF attachment protein NAPA Homo sapiens 78.90 15.93 4 25 P59998 Actin-related protein 2/3 complex subunit 4 ARPC4 Homo sapiens 67.76 11.31 2 24 O75947 ATP synthase subunit d, mitochondrial ATP5H Homo sapiens 69.10 22.36 3 24 O14958 Calsequestrin-2 CASQ2 Homo sapiens 126.06 28.82 6 24 P13073 Cytochrome c oxidase subunit 4 isoform 1, COX4I1 Homo sapiens 80.35 19.53 3 24 mitochondrial Q16698 2,4-dienoyl-CoA reductase, mitochondrial DECR1 Homo sapiens 107.00 20.60 4 24 P63167 Dynein light chain 1, cytoplasmic DYNLL1 Homo sapiens 73.08 49.44 3 24 P16401 Histone H1.5 HIST1H1B Homo sapiens 72.23 14.60 4 24 P54819 Adenylate kinase 2, mitochondrial AK2 Homo sapiens 112.91 21.34 3 24 O75489 NADH dehydrogenase [ubiquinone] iron- NDUFS3 Homo sapiens 90.78 21.97 4 24 sulfur protein 3, mitochondrial Q8NC51 Plasminogen activator inhibitor 1 RNA- SERBP1 Homo sapiens 77.71 13.73 3 24 binding protein P62244 40S ribosomal protein S15a RPS15A Homo sapiens 118.12 40.00 4 24 P17987 T-complex protein 1 subunit alpha TCP1 Homo sapiens 72.80 21.40 8 24 P50991 T-complex proten 1 subunit delta CCT4 Homo sapiens 89.75 5.38 2 24 Q99536 Synaptic vesicle membrane protein VAT-1 VAT1 Homo sapiens 78.40 15.78 4 24 homolog P08195 4F2 cell-surface antigen heavy chain SLC3A2 Homo sapiens 85.62 8.41 4 24 P52179 Myomesin-1 MYOM1 Homo sapiens 92.87 6.94 7 24 P14550 Alcohol dehydrogenase [NADP(+)] AKR1A1 Homo sapiens 96.16 22.46 4 23 P10768 S-formylglutathione hydrolase ESD Homo sapiens 103.70 33.33 5 23 Q12907 Vesicular integral-membrane protein VIP36 LMAN2 Homo sapiens 114.58 27.53 5 23 P26373 60S ribosomal protein L13 RPL13 Homo sapiens 80.63 16.11 3 23 P61353 60S ribosomal protein L27 RPL27 Homo sapiens 68.13 41.91 5 23 P62851 40S ribosomal protein S25 RPS25 Homo sapiens 75.11 24.00 4 23 P26447 Protein S100-A4 S100A4 Homo sapiens 66.34 19.80 2 23 Q9GZM7 Tubulointerstitial nephritis antigen-like TINAGL1 Homo sapiens 89.95 16.92 4 23 Q13510 Acid ceramidase ASAH1 Homo sapiens 107.39 10.13 2 23 P05556 Integrin beta-1 ITGB1 Homo sapiens 83.72 12.03 5 23 P11766 Alcohol dehydrogenase class-3 ADH5 Homo sapiens 111.95 31.82 5 22 Q9HDC9 Adipocyte plasma membrane-associated APMAP Homo sapiens 140.36 16.35 3 22 protein P00915 Carbonic anhydrase 1 CA1 Homo sapiens 83.52 17.62 3 22 Q97065 Cytoskeleton-associated protein 4 CKAP4 Homo sapiens 73.48 22.92 10 22 P53618 Coatomer subunit beta COPB1 Homo sapiens 101.52 5.35 3 22 Q9Y3I0 tRNA-splicing ligase RtcB homolog RTCB Homo sapiens 94.04 16.44 3 22 O43I69 Cytochrome b5 type B CYB5B Homo sapiens 145.18 36.30 2 22 Q8IZP2 Putative protein FAM10A4 ST13P4 Homo sapiens 100.91 18.33 3 22 P52565 Rho GDP-dissociation inhibitor 1 ARHGDIA Homo sapiens 90.83 25.00 4 22 Q02978 Mitochondrial 2-oxoglutarate/malate carrier SLC25A11 Homo sapiens 72.43 22.61 6 22 protein P62857 40S ribosomal protein S28 RPS28 Homo sapiens 74.20 33.33 2 22 Q16181 Septin-7 41889 Homo sapiens 127.43 9.38 2 22 P01591 Immunoglobulin J chain IGJ Homo sapiens 67.29 23.27 3 22 P23229 Integrain alpha-6 ITGA6 Homo sapiens 115.73 8.05 5 22 Q9BVK6 Transmembrane emp24 domain-containing TMED9 Homo sapiens 93.53 25.53 4 22 protein 9 P01019 Angiotensinogen AGT Homo sapiens 99.05 11.13 3 21 Q9ULZ3 Apoptosis-associated speck-like protein PYCARD Homo sapiens 100.42 15.90 2 21 containing a CARD O75531 Barrier-to-autointegration factor BANF1 Homo sapiens 78.08 40.45 2 21 P61604 10 kDa heat shock protein, mitochondrial HSPE1 Homo sapiens 79.74 25.49 2 21 P02741 C-reactive protein CRP Homo sapiens 58.24 17.41 5 21 P02765 Alpha-2-HS-glycoprotein AHSG Homo sapiens 97.90 16.89 3 21 Q14152 Eukaryotic translation initiation factor 3 EIF3A Homo sapiens 61.17 5.14 5 21 subunit A Q9UN36 Protein NDRG2 NDRG2 Homo sapiens 110.96 30.46 5 21 P07225 Vitamin K-dependent protein S PROS1 Homo sapiens 120.92 6.07 2 21 P62750 60S ribosomal protein L23a RPL23A Homo sapiens 62.82 21.15 3 21 P23297 Protein S100-A1 S100A1 Homo sapiens 93.09 23.40 2 21 Q07666 KH domain-containing. RNA-binding, signal KHDRBS1 Homo sapiens 107.45 7.67 2 21 transduction-associated protein 1 Q9BS26 Endoplasmic reticulum resident protein 44 ERP44 Homo sapiens 146.67 17.49 4 21 Q96QK1 Vacuolar protein sorting-associatad protein VPS35 Homo sapiens 65.50 7.29 4 21 35 Q03591 Complement factor H-related protein 1 CFHR1 Homo sapiens 74.21 18.48 4 21 P16144 Integrin beta-4 ITGB4 Homo sapiens 99.62 4.72 4 21 P11279 Lysosome-associated membrane LAMP1 Homo sapiens 83.40 8.63 3 21 glycoprotein 1 P27695 DNA-(apurinic or apyrimidinic site) lyase APEX1 Homo sapiens 94.50 16.98 3 20 Q12797 Aspartyl/asparaginyl beta-hydroxylase ASPH Homo sapiens 94.75 7.26 3 20 Q9UGM3 Deleted in malignant brain tumors 1 protein DMBT1 Homo sapiens 72.30 15.04 3 25 O75874 Isocitrate dehydrogenase [NADP] IDH1 Homo sapiens 87.46 18.60 5 20 cytoplasmic P60866 40S ribosomal protein S20 RPS20 Homo sapiens 80.66 19.33 2 20 P04271 Protein S100-B S100B Homo sapiens 130.02 40.22 2 20 P07602 Proactivator polypeptide PSAP Homo sapiens 50.52 6.49 3 20 P68036 Ubiquitin-conjugating enzyme E2 L3 UBE2L3 Homo sapiens 111.70 24.03 2 20 P06727 Apolipoprotein A-IV APOA4 Homo sapiens 57.03 16.67 5 19 Q9NVJ2 ADP-ribosylation factor-like protein 8B ARL8B Homo sapiens 89.71 22.58 3 19 P36542 ATP synthase subunit gamma, mitochondrial ATP5C1 Homo sapiens 51.19 21.48 4 19 P51659 Peroxisomal multifunctional enzyme type 2 HSD17B4 Homo sapiens 102.09 13.45 5 19 O60506 Heterogeneous nuclear ribonucleoprotein Q SYNCR1P Homo sapiens 55.74 7.87 4 19 P01765 Ig heavy chain V-III region TIL HV304 Homo sapiens 90.67 26.09 2 19 P42704 Leucine-rich PPR motif-containing protein, LRPPRC Homo sapiens 65.49 6.53 6 19 mitochondrial Q53GG5 PDZ and LIM domain protein 3 PDLIM3 Homo sapiens 106.45 15.66 3 19 P46776 60S ribosomal protein L27a RPL27A Homo sapiens 52.70 14.86 2 19 P63316 Troponin C, slow skeletal and cardiac TNNC1 Homo sapiens 70.44 16.15 3 19 muscles Q9BXX0 EMILIN-2 EMILIN2 Homo sapiens 66.38 4.94 3 19 Q16836 Hydroxyacyl-coenzyme A dehydrogenase, HADH Homo sapiens 91.31 36.62 5 19 mitochondrial Q9HC84 Mucin-5B MUC5B Homo sapiens 70.98 3.04 4 19 P22061 Protein-L-isoaspartate(D-aspartate) O- PCMT1 Homo sapiens 122.95 26.43 2 19 methyltransferase Q92841 Probable ATP-dependent RNA helicase DDX17 Homo sapiens 63.73 13.03 6 19 DDX17 P02656 Apolipoprotein C-III APOC3 Homo sapiens 81.52 27.27 2 18 P35606 Coatomer subunit beta COPB2 Homo sapiens 70.13 12.58 6 18 P13804 Electron transfer flavoprotein subunit alpha, ETFA Homo sapiens 55.74 13.81 3 18 mitochondrial P01766 Ig heavy chain V-III region BRO HV305 Homo sapiens 83.54 25.00 2 18 P50213 Isocitrate dehydrogenase [NAD] subunit IDH3A Homo sapiens 89.89 17.76 4 18 alpha, mitochondrial Q99538 Legumain LGMN Homo sapiens 76.81 10.16 2 18 Q04760 Lactoylglutathione lyase GLO1 Homo sapiens 51.46 29.89 4 18 P55209 Nucleosome assembly protein 1-like 1 NAP1L1 Homo sapiens 71.86 19.95 4 18 P62280 40S ribosomal protein S11 RPS11 Homo sapiens 59.38 31.65 4 18 P62753 40S ribosomal protein S6 RPS6 Homo sapiens 63.34 14.86 3 18 Q14108 Lysosome membrane protein 2 SCARB2 Homo sapiens 80.31 11.09 3 18 P40227 T-complex protein 1 subunit zeta CCT6A Homo sapiens 120.87 12.62 3 18 P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP5 Homo sapiens 86.69 8.86 3 18 Q14CN2 Calcium-activated chloride channel regulator 4 CLCA4 Homo sapiens 68.23 13.06 6 18 Q9UMN6 26S proteosome non-ATPase regulatory PSMD13 Homo sapiens 80.72 13.03 3 18 subunit 13 P02730 Band 3 anion transport protein SLC4A1 Homo sapiens 89.76 10.98 5 17 P34810 Macrosialin CD68 Homo sapiens 96.51 15.25 2 17 P78417 Glutathione S-transferase omega-1 GSTO1 Homo sapiens 48.66 7.88 2 17 P11940 Polyadenylate-binding protein 1 PABPC1 Homo sapiens 55.95 10.38 5 17 P62913 60S ribosomal protein L11 RPL11 Homo sapiens 56.30 12.92 2 17 P42677 40S ribosomal protein S27 RPS27 Homo sapiens 48.36 28.57 2 17 Q9UHD8 Septin-9 41891 Homo sapiens 69.77 8.70 3 17 P51571 Translocon-associated protein subunit delta SSR4 Homo sapiens 56.50 24.86 3 17 P40394 Alcohol dehydrogenase class 4 mu/sigma ADH7 Homo sapiens 124.34 14.51 3 17 chain P20073 Annexin A7 ANXA7 Homo sapiens 67.13 9.63 3 17 Q5SSJ5 Heterochromatin protein 1-binding protein 3 HP1BP3 Homo sapiens 64.95 6.87 2 17 P20591 Interferon-induced GTP-binding protein Mx1 MX1 Homo sapiens 88.82 16.47 6 17 P35611 Alpha-adducin ADD1 Homo sapiens 92.65 8.41 3 16 P24539 ATP synthase subunit b, mitochondrial ATP5F1 Homo sapiens 57.61 19.53 4 16 P02462 Collagen alpha-1(IV) chain COL4A1 Homo sapiens 61.11 4.79 5 16 P08246 Neutrophil elastase ELANE Homo sapiens 108.82 20.60 2 16 P52566 Rho GDP-dissociation inhibitor 2 ARHGDIB Homo sapiens 77.52 33.83 3 16 Q1KMD3 Heterogeneous nuclear ribonucleoprotein U- HNRNPUL2 Homo sapiens 62.82 10.98 4 16 like protein 2 Q9Y4L1 Hypoxia up-regulated protein 1 HYOU1 Homo sapiens 66.01 9.21 5 16 P05198 Eukaryotic translation initiation factor 2 EIF2S1 Homo sapiens 64.58 23.81 4 16 subunit 1 Q16795 NADH denydrogenase [Ubiquinone] 1 alpha NDUFA9 Homo sapiens 51.83 17.77 5 16 subcomplex subunit 9, mitochondrial Q14980 Nuclear mitotic apparatus protein 1 NUMA1 Homo sapiens 89.24 2.84 3 16 Q9UMS4 Pre-mRNA-processing factor 19 PRPF19 Homo sapiens 79.00 6.35 2 16 Q15046 Lysine-tRNA ligase KARS Homo sapiens 51.73 9.21 3 16 P22735 Protein-glutamine gamma- TGM1 Homo sapiens 62.57 12.12 5 16 glutamyltransferase K Q9Y3B3 Transmembrane emp24 domain-containing TMED7 Homo sapiens 65.77 19.64 3 16 protein 7 P47985 Cytochrome b-c1 complex subunit Rieske, UQCRFS1 Homo sapiens 76.88 17.52 3 16 miochondrial O75339 Cartilage intermediate layer protein 1 CILP Homo sapiens 49.16 4.65 4 16 P11047 Laminin subunit gamma-1 LAMC1 Homo sapiens 58.80 5.03 5 16 P13796 Plastin-2 LCP1 Homo sapiens 56.95 11.32 5 16 P61160 Actin-related protein 2 ACTR2 Homo sapiens 43.44 8.88 3 15 O15144 Actin-related protein 2/3 complex subunit 2 ARPC2 Homo sapiens 53.55 28.67 6 15 P07358 Complement component C8 beta chain C8B Homo sapiens 69.74 8.12 2 15 O75131 Copine-3 CPNE3 Homo sapiens 67.21 11.17 4 15 P22087 rRNA 2-O-methyltransferase fibrillanin FBL Homo sapiens 50.51 15.89 4 15 Q93052 Lipoma-preferred partner LPP Homo sapiens 96.40 3.92 2 15 Q9UHQ9 NADH-cytochrome b5 reductase 1 CYB5R1 Homo sapiens 107.11 15.41 2 15 P13667 Protein disulfide-isomerase A4 PDIA4 Homo sapiens 45.77 10.85 5 15 Q15437 Protein transport protein Sec23B SEC23B Homo sapiens 64.93 6.52 2 15 P48643 T-complex protein 1 subunit epsilon CCT5 Homo sapiens 71.26 14.97 4 15 P49419 Alpha-aminoadipic semialdehyde ALDH7A1 Homo sapiens 47.15 16.33 5 15 dehydrogenase P01031 Complement C5 C5 Homo sapiens 60.01 5.19 5 15 O14561 Acyl carrier protein, mitochondrial NDUFAB1 Homo sapiens 63.69 15.38 2 14 O00499 Myc box-dependent-interacting protein 1 BIN1 Homo sapiens 61.79 14.67 5 14 P30043 Flavin reductase (NADPH) BLVRB Homo sapiens 45.07 23.79 3 14 P55290 Cadherin-13 CDH13 Homo sapiens 63.95 4.91 2 14 Q13938 Calcyphosin CAPS Homo sapiens 49.97 26.98 4 14 P42126 Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Homo sapiens 44.26 20.53 4 14 Q9H4M9 EH domain-containing protein 1 EHD1 Homo sapiens 58.11 7.49 2 14 P19367 Hexokinase-1 HK1 Homo sapiens 52.93 9.16 6 14 O60662 Kelch repeat and BTB domain-containing KLHL41 Homo sapiens 58.11 8.42 5 14 protein 10 P10620 Microsomal glutathione S-transferase 1 MGST1 Homo sapiens 39.47 18.71 2 14 Q13765 Nascent polypeptide-associated complex NACA Homo sapiens 45.56 12.56 2 14 subunit alpha O95299 NADH dehydrogenase [ubiquinone] 1 alpha NDUFA10 Homo sapiens 71.85 13.24 2 14 subcomplex subunit 10, mitochondrial Q9UHG3 Prenylcysteine oxidase 1 PCYOX1 Homo sapiens 50.92 12.28 4 14 Q15293 Reticulocalbin-1 RCN1 Homo sapiens 54.12 18.13 4 14 Q07955 Serine/arginine-rich splicing factor 1 SRSF1 Homo sapiens 46.76 17.34 3 14 P30626 Sorcin SRI Homo sapiens 52.69 16.16 2 14 Q04837 Single-stranded DNA-binding protein SSBP1 Homo sapiens 45.28 32.43 3 14 mitochondrial Q9UJZ1 Stomatin-like protein 2 STOML2 Homo sapiens 49.54 17.13 3 14 O75746 Calcium-binding mitochondrial carrier protein SLC25A12 Homo sapiens 73.38 8.11 2 14 Aralar1 Q9Y6C2 EMILIN-1 EMILIN1 Homo sapiens 49.93 8.56 6 14 Q07954 Prolow-density lipoprotein receptor-related LRP1 Homo sapiens 62.18 2.07 5 14 protein 1 P36952 Serpin B5 SERPINB5 Homo sapiens 55.15 14.13 3 14 P20290 Transcription factor BTF3 BTF3 Homo sapiens 74.92 22.82 2 13 P02745 Complement C1q subcomponent subunit A C1QA Homo sapiens 75.24 13.47 2 13 P47756 F-actin-capping protein subunit beta CAPZB Homo sapiens 51.06 26.35 4 13 Q9Y678 Coatomer subunit gamma-1 COPG1 Homo sapiens 48.48 11.21 4 13 P05413 Fatty acid-binding protein, heart FABP3 Homo sapiens 41.42 38.35 4 13 P14314 Glucosidase 2 subunit beta PRKCSH Homo sapiens 51.99 11.36 5 13 O00303 Eukaryotic translation initiation factor 3 EIF3F Homo sapiens 53.04 19.05 4 13 subunit F P04434 Ig kappa chain V-III region VH (Fragment) KV310 Homo sapiens 33.54 23.28 2 13 O00232 26S proteasome non-ATPase regulatory PSMD12 Homo sapiens 45.14 7.46 2 13 subunit 12 P98179 Putative RNA-binding protein 3 RBM3 Homo sapiens 66.79 31.85 2 13 P21589 5-nucleotidase NT5E Homo sapiens 54.86 9.23 2 12 P00966 Argininosuccinate synthase ASS1 Homo sapiens 69.29 10.19 2 12 P08571 Monocyte differentiaton antigen CD14 CD14 Homo sapiens 50.36 14.40 3 12 Q9ULV4 Coronin-1C CORO1C Homo sapiens 75.32 13.29 2 12 P21912 Succinate dehydrogenase [ubiquinone] iron- SDHB Homo sapiens 44.99 10.71 2 12 sulfur subunit, mitochondrial P35573 Glycogen debrenching enzyme AGL Homo sapiens 60.07 3.26 3 12 Q96AB3 Isochorismatase domain-containing protein 2, ISOC2 Homo sapiens 55.91 25.85 2 12 mitochondrial P30085 UMP-CMP kinase CMPK1 Homo sapiens 56.96 22.96 3 12 P80186 Neutrophil gelatinase-associated lipocalin LCN2 Homo sapiens 35.66 26.77 3 12 P61970 Nuclear transport factor 2 NUTF2 Homo sapiens 70.89 33.86 2 12 O75915 PRA1 family protein 3 ARL6IP5 Homo sapiens 42.87 15.96 2 12 P62491 Ras-related protein Rab-11A RAB11A Homo sapiens 36.42 16.20 3 12 P84098 60S ribosomal protein L19 RPL19 Homo sapiens 35.15 30.10 6 12 Q01105 Protein SET SET Homo sapiens 69.40 17.24 2 12 P39687 Acidic leucine-rich nuclear phosphoprotein 32 ANP32A Homo sapiens 38.78 14.06 3 11 family member A Q96CW1 AP-2 complex subunit mu AP2M1 Homo sapiens 50.41 11.72 3 11 P02652 Apolipoprotein A-II APOA2 Homo sapiens 30.45 39.00 3 11 P18859 ATP synthase-coupling factor 6, ATP5J Homo sapiens 45.89 30.56 2 11 mitochondrial Q99715 Collagen alpha-1(XII) chain COL12A1 Homo sapiens 42.85 1.99 4 11 Q9Y394 Dehydrogenase/reductase SDR family DHRS7 Homo sapiens 51.65 16.52 3 11 member 7 O43143 Putative pre-mRNA-splicing factor ATP- DHX15 Homo sapiens 35.61 4.28 2 11 dependant RNA helicase DHX15 P11166 Solute carrier family 2, facilitated glucose SLC2A1 Homo sapiens 29.34 6.30 3 11 transporter member 1 P38159 RNA-binding motif protein, X chromosome RBMX Homo sapiens 31.82 5.37 2 11 P01714 Ig lambda chain V-III region SH LV301 Homo sapiens 37.60 25.00 2 11 P23368 NAD-dependent malic enzyme, mitochondrial ME2 Homo sapiens 64.29 15.07 3 11 Q9Y6C9 Mitochondrial carrier homolog 2 MTCH2 Homo sapiens 42.05 16.83 3 11 P49821 NADH dehydrogenase [ubiquinone] NDUFV1 Homo sapiens 40.34 17.24 4 11 flavoprotein 1, mitochondrial Q9Y2J8 Protein-arginine deiminase type-2 PADI2 Homo sapiens 55.16 5.56 2 11 P01833 Polymeric immunoglobulin receptor PIGR Homo sapiens 59.96 4.84 2 11 P61019 Ras-related protein Rab-2A RAB2A Homo sapiens 38.60 12.74 2 11 P40763 Signal transducer and activator of STAT3 Homo sapiens 75.61 8.70 3 11 transcription 3 Q15363 Transmembrane emp24 domain-containing TMED2 Homo sapiens 37.40 18.41 3 11 protein 2 P07996 Thrombospondin-1 THBS1 Homo sapiens 51.87 2.74 2 11 O75643 U5 small nuclear ribonucleoprotein 200 kDa SNRNP200 Homo sapiens 58.36 4.21 4 11 helicase Q15029 116 kDa U5 small nuclear ribonucleoprotein EFTUD2 Homo sapiens 69.20 3.81 2 11 component Q9UH99 SUN domain-containing protein 2 SUN2 Homo sapiens 49.31 10.46 4 11 O75533 Splicing factor 3B subunit 1 SF3B1 Homo sapiens 48.28 2.45 2 11 P46977 Dolichyl-diphosphooligosaccharide-protein STT3A Homo sapiens 64.42 5.82 2 11 glycosyltransferase subunit STT3A Q16658 Fascin FSCN1 Homo sapiens 51.61 8.11 2 10 Q9NZ01 Very-long-chain enoyl-CoA reductase TECR Homo sapiens 36.79 9.42 2 10 P08263 Glutathione S-transferase A1 GSTA1 Homo sapiens 28.39 17.57 3 10 Q13751 Laminin subunit beta-3 LAMB3 Homo sapiens 41.29 6.06 4 10 P37837 Transaldolase TALDO1 Homo sapiens 32.08 14.54 4 10 Q6ZMU5 Tripartite motif-containing protein 72 TRIM72 Homo sapiens 52.07 14.47 4 10 P53634 Dipeptidyl peptidase 1 CTSC Homo sapiens 42.71 12.31 3 10 P14543 Nidogen-1 NID1 Homo sapiens 41.25 5.53 4 10 Q9NYU2 UDP-glucose:glycoprotein UGGT1 Homo sapiens 34.11 6.88 5 10 glycosyltransferase 1 B0FP48 Uroplakin-3b-like protein UPK3BL Homo sapiens 29.21 13.31 3 10 P61163 Alpha-centractin ACTR1A Homo sapiens 38.24 10.11 2 9 P04745 Alpha-amylase 1 AMY1A Homo sapiens 49.22 15.07 4 9 P51572 B-cell receptor-associated protein 31 BCAP31 Homo sapiens 25.93 21.54 4 9 P24592 Insulin-like growth factor-binding protein 6 IGFBP6 Homo sapiens 48.09 18.33 2 9 Q13421 Mesothelin MSLN Homo sapiens 42.32 6.35 2 9 P22307 Non-specific lipid-transfer protein SCP2 Homo sapiens 26.93 6.95 3 9 P55786 Puromycin-sensitive aminopeptidase NPEPPS Homo sapiens 30.12 6.42 3 9 P61254 60S ribosomal protein L26 RPL26 Homo sapiens 23.65 17.93 3 9 P67812 Signal peptidase complex catalytic subunit SEC11A Homo sapiens 22.32 15.64 3 9 SEC11A Q5VXT5 Synaptophysin-like protein 2 SYPL2 Homo sapiens 33.05 10.66 2 9 P13693 Translationally-controlled tumor protein TPT1 Homo sapiens 31.41 12.21 2 9 Q9UDW1 Cytochrome b-c1 complex subunit 9 UQCR10 Homo sapiens 29.74 38.10 2 9 Q6YHK3 CD109 antigen CD109 Homo sapiens 30.44 3.88 3 8 Q9Y224 UPF0568 protein C14orf166 C14orf166 Homo sapiens 41.55 17.62 3 8 Q16610 Extracellular matrix protein 1 ECM1 Homo sapiens 35.88 6.67 2 8 Q13347 Eukaryotic translation initiation factor 3 EIF3I Homo sapiens 36.42 16.31 3 8 subunit I P40261 Nicotinamide N-methyltransferase NNMT Homo sapiens 39.05 12.12 2 8 O75340 Programmed cell death protein 6 PDCD6 Homo sapiens 25.68 12.57 2 8 P62714 Serine/threonine-protein phosphatase 2A PPP2CB Homo sapiens 42.30 12.94 2 8 catalytic subunit beta isoform P28066 Proteasome subunit alpha type-5 PSMA5 Homo sapiens 35.94 29.88 4 8 P61224 Ras-related protein Rap-1b RAP1B Homo sapiens 25.05 26.09 4 8 Q9Y265 RuvB-like 1 RUVBL1 Homo sapiens 28.51 8.99 3 8 P61619 Protein transport protein Sec61 subunit alpha SEC61A1 Homo sapiens 28.34 6.51 2 8 isoform 1 Q8TCJ2 Dolichyl-diphosphooligosaccharide--protein STT3B Homo sapiens 38.82 3.51 2 8 glycosyltransferase subunit STT3B Q92896 Golgi apparatus protein 1 GLG1 Homo sapiens 48.26 4.92 3 8 P10515 Dihydrolipoyllysine-residue acetyltransferase DLAT Homo sapiens 31.01 10.51 4 8 component of pyruvate dehydrogenase complex, mitochondrial Q6NUK1 Calcium-binding mitochondrial carrier protein SLC25A24 Homo sapiens 21.03 6.92 3 8 SCaMC-1 O43488 Aflatoxin B1 aldehyde reductase member 2 AKR7A2 Homo sapiens 44.29 13.37 2 7 O15511 Actin-related protein 2/3 complex subunit 5 ARPC5 Homo sapiens 27.05 21.19 2 7 P34897 Serine hydroxymethyltransferase, SHMT2 Homo sapiens 18.65 5.36 2 7 mitochondrial P07305 Histone H1.0 H1F0 Homo sapiens 17.16 11.34 2 7 Q12906 Interleukin enhancer-binding factor 3 ILF3 Homo sapiens 21.77 4.47 3 7 Q08380 Galectin-3-binding protein LGALS3BP Homo sapiens 29.58 4.96 2 7 P16050 Arachidonate 15-lipoxygenase ALOX15 Homo sapiens 33.24 6.19 2 7 P01700 Ig lambda chain V-I region HA LV102 Homo sapiens 19.51 18.75 2 7 Q99972 Myocilin MYOC Homo sapiens 20.28 10.91 4 7 Q96AC1 Fermitin family homolog 2 FERMT2 Homo sapiens 22.01 5.00 2 7 Q9Y446 Plakophilin-3 PKP3 Homo sapiens 25.64 6.15 3 7 P25786 Proteasome subunit alpha type-1 PSMA1 Homo sapiens 32.33 19.77 3 7 Q99460 26S proteasome non-ATPase regulatory PSMD1 Homo sapiens 30.78 5.98 3 7 subunit 1 P06703 Protein S100-A6 S100A6 Homo sapiens 24.60 40.00 3 7 P23526 Adenosylhomocysteinase AHCY Homo sapiens 25.52 10.65 3 7 Q96PL1 Secretoglobin family 3A member 2 SCGB3A2 Homo sapiens 27.23 33.33 2 7 P54577 Tyrosine--tRNA ligase, cytoplasmic YARS Homo sapiens 34.21 10.61 3 7 O60701 UDP-glucose 6-dehydrogenase UGDH Homo sapiens 22.69 8.30 2 7 P40121 Macrophage-capping protein CAPG Homo sapiens 27.36 13.51 3 7 Q7L2H7 Eukaryotic translation initiation factor 3 EIF3M Homo sapiens 34.24 12.57 3 7 subunit M Q6YN16 Hydroxysteroid dehydrogenase-like protein 2 HSDL2 Homo sapiens 27.28 8.85 2 7 Q969G5 Protein kinase C delta-binding protein PRKCDBP Homo sapiens 24.98 13.79 3 7 P35613 Basigin BSG Homo sapiens 25.29 8.31 2 6 P09871 Complement C1s subcomponent C1S Homo sapiens 23.20 4.36 2 6 Q92499 ATP-dependent RNA helicase DDX1 DDX1 Homo sapiens 28.65 6.89 3 6 Q9UBX5 Fibulin-5 FBLN5 Homo sapiens 19.62 6.70 2 6 O75955 Fictillin-1 FLOT1 Homo sapiens 20.47 7.73 2 6 P21695 Glycerol-3-phosphate dehydrogenase GPD1 Homo sapiens 27.44 22.64 4 6 [NAD(+)], cytoplasmic O14558 Heat shock protein beta-6 HSPB6 Homo sapiens 23.37 21.88 2 6 P20810 Calpasiatin CAST Homo sapiens 25.02 6.21 2 6 Q12995 Interleukin enhancer-binding factor 2 ILF2 Homo sapiens 23.04 18.97 4 6 P48729 Casein kinase I isoform alpha CSNK1A1 Homo sapiens 15.74 8.53 2 6 P80748 Ig lambda chain V-III region LOI LV302 Homo sapiens 19.76 21.62 2 6 P51970 NADH dehydrogenase [ubiquinone] 1 alpha NDUFA8 Homo sapiens 21.24 29.07 3 6 subcomplex subunit 8 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 PRPF8 Homo sapiens 27.11 1.88 2 6 P62333 26S protease regulatory subunit 10B PSMC6 Homo sapiens 22.70 7.97 2 6 P63000 Ras-related C3 botulinum toxin substrate 1 RAC1 Homo sapiens 16.60 22.40 4 6 Q15393 Splicing factor 3B subunit 3 SF3B3 Homo sapiens 28.58 3.20 2 6 O75368 SH3 domain-binding glutamic acid-rich-like SH3BGRL Homo sapiens 16.99 27.19 2 6 protein P26640 Valine-tRNA ligase VARS Homo sapiens 25.03 2.37 2 6 P61421 V-type proton ATPase subunit d 1 ATP6V0D1 Homo sapiens 20.75 10.26 2 6 Q14254 Flotillin-2 FLOT2 Homo sapiens 22.29 7.24 2 6 P27169 Serum paraoxonase/arylesterase 1 PON1 Homo sapiens 19.01 21.97 3 6 P04275 von Willebrand factor VWF Homo sapiens 18.91 1.03 2 6 P51858 Hepatoma-derived growth factor HDGF Homo sapiens 21.84 14.17 2 5 Q96CX2 BTB/POZ domain-containing protein KCTD12 KCTD12 Homo sapiens 13.69 7.08 2 5 Q13753 Laminin subunit gamma-2 LAMC2 Homo sapiens 29.52 4.11 2 5 P43243 Matrin-3 MATR3 Homo sapiens 15.97 3.78 2 5 Q9NP98 Myozenin-1 MYOZ1 Homo sapiens 25.04 11.04 2 5 Q9P2E9 Ribosome-binding protein 1 RRBP1 Homo sapiens 13.24 2.34 3 5 P49458 Signal recognition particle 9 kDa protein SRP9 Homo sapiens 14.05 23.26 2 5 P42224 Signal transducer and activator of STAT1 Homo sapiens 18.45 4.00 2 5 transcription 1-alpha/beta O14907 Tax1-binding protein 3 TAX1BP3 Homo sapiens 18.96 28.23 2 5 Q04446 1,4-alpha-glucan-branching enzyme GBE1 Homo sapiens 20.75 5.13 2 5 O15230 Laminin subunit alpha-5 LAMA5 Homo sapiens 29.62 1.35 2 5 Q00341 Vigilin HDLBP Homo sapiens 24.79 3.08 2 5 P30049 ATP synthase subunit delta, mitochondrial ATP5D Homo sapiens 12.28 13.69 2 4 P23141 Liver carboxylesterase 1 CES1 Homo sapiens 14.18 5.47 2 4 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate GRHPR Homo sapiens 17.86 12.20 2 4 reductase P07686 Beta-hexosaminidase subunit beta HEXB Homo sapiens 18.55 8.63 2 4 P05455 Lupus La protein SSB Homo sapiens 17.39 10.78 3 4 P19404 NADH dehydrogenase [ubiquinone] NDUFV2 Homo sapiens 10.94 9.64 2 4 flavoprotein 2, mitochondrial Q13423 NAD(P) transhydrogenase, mitochondrial NNT Homo sapiens 21.45 3.41 2 4 P04181 Ornithine aminotransferase, mitochondrial OAT Homo sapiens 11.54 7.29 2 4 P11498 Pyruvate carboxylase, mitochondrial PC Homo sapiens 24.43 3.40 2 4 Q00765 Receptor expression-enhancing protein 5 REEP5 Homo sapiens 11.75 10.05 2 4 Q9NVA2 Septin-11 41893 Homo sapiens 9.98 4.90 2 4 Q01130 Serine/arginine-rich splicing factor 2 SRSF2 Homo sapiens 13.67 12.67 2 4 P38606 V-type proton ATPase catalytic subunit A ATP6V1A Homo sapiens 15.43 7.46 3 4 O14980 Exportin-1 XPO1 Homo sapiens 21.82 3.27 2 4 Q8IVF2 Protein AHNAK2 AHNAK2 Homo sapiens 11.71 5.18 2 4 Q9UBG3 Cornulin CRNN Homo sapiens 15.63 16.77 4 4 Q06033 Inter-alpha-trypsin inhibitor heavy chain H3 ITIH3 Homo sapiens 20.77 5.51 2 4 Q16787 Laminin subunit alpha-3 LAMA3 Homo sapiens 25.74 1.32 2 4 P62330 ADP-ribosylation factor 6 ARF6 Homo sapiens 11.13 20.00 2 3 P50402 Emerin EMD Homo sapiens 11.98 16.54 2 3 P15104 Glutamine synthetase GLUL Homo sapiens 11.91 9.92 2 3 P10644 cAMP-dependent protein kinase type I-alpha PRKAR1A Homo sapiens 13.14 7.87 2 3 regulatory subunit P13473 Lysosome-associated membrane LAMP2 Homo sapiens 9.53 4.88 2 3 glycoprotein 2 Q9BQ69 O-acetyl-ADP-ribose deacetylase MACROD1 MACROD1 Homo sapiens 15.78 11.38 2 3 P53007 Tricarboxylate transport protein, SLC25A1 Homo sapiens 13.07 15.11 2 3 mitochondrial P49327 Fatty acid synthase FASN Homo sapiens 13.24 2.35 3 3 P07476 Involucrin IVL Homo sapiens 14.25 6.84 2 3 Q5VTT5 Myomesin-3 MYOM3 Homo sapiens 12.97 4.73 3 3 P07814 Bifunctional glutamate/proline-tRNA ligase EPRS Homo sapiens 17.22 3.24 2 3 P12830 Cadherin-1 CDH1 Homo sapiens 6.40 4.08 2 2 P04040 Catalase CAT Homo sapiens 8.25 6.45 2 2 Q13217 DnaJ homolog subfamiy C member 3 DNAJC3 Homo sapiens 9.96 9.72 2 2 Q9UBY9 Heat shock protein beta-7 HSPB7 Homo sapiens 6.55 18.82 2 2 Q9Y262 Eukaryotic translation initiation factor 3 EIF3L Homo sapiens 9.03 4.26 2 2 subunit L Q92804 TATA-binding protein-associated factor 2N TAF15 Homo sapiens 5.57 4.39 2 2 P02753 Retinol-binding protein 4 RBP4 Homo sapiens 6.32 9.95 2 2 Q8NB12 SET and MYND domain containing protein 1 SMYD1 Homo sapiens 5.69 6.53 2 2 Q9NSE4 Isoleucine-tRNA ligase, mitochondrial IARS2 Homo sapiens 6.92 2.77 2 2 Q9HD45 Transmembrane 9 superfamily member 3 TM9SF3 Homo sapiens 6.34 5.26 2 2 Q9P0L0 Vesicle-associated membrane protein- VAPA Homo sapiens 8.47 14.06 2 2 associated protein A
(97) TABLE-US-00002 TABLE 2 Gene ontology (biological process, cellular component and molecular function) terms enriched in the engineered VF mucosa proteome. Enriched ontology terms were identified using the BINGO algorithm. The term list shown here corresponds to the functional enrichment map presented in FIG. 3E. Terms are listed in order of ascending Benjamini Hochberg-adjusted P-value. Gene ontology term Description Adjusted P-value GO:44444 cytoplasmic part 0.00E+00 GO:5737 cytoplasm 0.00E+00 GO:5829 cytosol 0.00E+00 GO:44424 intracellular part 0.00E+00 GO:44422 organelle part 0.00E+00 GO:44446 intracellular organelle part 0.00E+00 GO:5515 protein binding 0.00E+00 GO:5622 intracellular 0.00E+00 GO:43226 organelle 0.00E+00 GO:43229 intracellular organelle 0.00E+00 GO:44464 cell part 0.00E+00 GO:5623 cell 0.00E+00 GO:16043 cellular component organization 0.00E+00 GO:71840 cellular component organization or biogenesis 0.00E+00 GO:43227 membrane-bounded organelle 1.54E98 GO:9056 catabolic process 1.32E97 GO:32991 macromolecular complex 7.91E96 GO:43231 intracellular membrane-bounded organelle 2.82E92 GO:1901575 organic substance catabolic process 1.10E90 GO:31974 membrane-enclosed lumen 6.02E90 GO:43233 organelle lumen 3.94E89 GO:44248 cellular catabolic process 5.02E86 GO:5575 cellular component 6.23E84 GO:44281 small molecule metabolic process 1.14E83 GO:16071 mRNA metabolic process 1.40E83 GO:70013 intracellular organelle lumen 8.21E83 GO:16032 viral reproduction 4.94E82 GO:44764 multi-organism cellular process 6.49E82 GO:22411 cellular component disassembly 1.09E77 GO:19083 viral transcription 2.90E77 GO:44710 single-organism metabolic process 3.71E77 GO:9987 cellular process 5.80E77 GO:43933 macromolecular complex subunit organization 6.37E75 GO:44237 cellular metabolic process 1.39E74 GO:22415 viral reproductive process 8.03E74 GO:19080 viral genome expression 1.63E73 GO:6614 SRP-dependent cotranslational protein targeting to membrane 3.08E73 GO:22626 cytosolic ribosome 3.50E72 GO:19058 viral infectious cycle 3.83E72 GO:45047 protein targeting to ER 8.85E72 GO:6414 translational elongation 1.01E71 GO:72599 establishment of protein localization to endoplasmic reticulum 1.59E71 GO:6613 cotranslational protein targeting to membrane 1.59E71 GO:6415 translational termination 2.24E71 GO:71822 protein complex subunit organization 3.93E71 GO:184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 6.64E71 GO:70972 protein localization to endoplasmic reticulum 1.49E70 GO:5488 binding 6.41E69 GO:43624 cellular protein complex disassembly 3.58E68 GO:71704 organic substance metabolic process 4.71E68 GO:43241 protein complex disassembly 3.35E66 GO:44699 single-organism process 3.35E66 GO:51649 establishment of localization in cell 4.99E66 GO:51641 cellular localization 7.77E66 GO:6612 protein targeting to membrane 5.56E64 GO:32984 macromolecular complex disassembly 2.81E63 GO:31988 membrane-bounded vesicle 4.70E63 GO:43228 non-membrane-bounded organelle 8.25E63 GO:43232 intracellular non-membrane-bounded organelle 8.25E63 GO:31982 vesicle 1.13E62 GO:44238 primary metabolic process 1.22E62 GO:44703 multi-organism reproductive process 4.22E62 GO:46700 heterocycle catabolic process 1.06E61 GO:34655 nucleobase-containing compound catabolic process 1.21E61 GO:6402 mRNA catabolic process 2.73E61 GO:46907 intracellular transport 3.34E61 GO:30529 ribonucleoprotein complex 3.34E61 GO:6413 translational initiation 3.74E61 GO:1901361 organic cyclic compound catabolic process 4.66E61 GO:44270 cellular nitrogen compound catabolic process 5.09E61 GO:956 nuclear-transcribed mRNA catabolic process 5.26E61 GO:44763 single-organism cellular process 5.79E61 GO:19439 aromatic compound catabolic process 6.81E61 GO:51704 multi-organism process 1.33E60 GO:16482 cytoplasmic transport 1.49E59 GO:44445 cytosolic part 1.05E58 GO:33036 macromolecule localization 2.01E58 GO:6401 RNA catabolic process 2.63E58 GO:45184 establishment of protein localization 9.90E58 GO:8104 protein localization 1.15E57 GO:6807 nitrogen compound metabolic process 1.41E57 GO:72594 establishment of protein localization to organelle 5.33E57 GO:15031 protein transport 6.04E57 GO:5198 structural molecule activity 6.40E57 GO:6605 protein targeting 1.79E56 GO:9057 macromolecule catabolic process 3.33E56 GO:8152 metabolic process 1.14E55 GO:42470 melanosome 1.61E55 GO:48770 pigment granule 1.61E55 GO:44391 ribosomal subunit 3.17E54 GO:34641 cellular nitrogen compound metabolic process 2.68E53 GO:6886 intracellular protein transport 7.01E53 GO:34613 cellular protein localization 5.66E52 GO:70727 cellular macromolecule localization 7.49E52 GO:33365 protein localization to organelle 3.51E51 GO:71702 organic substance transport 3.13E50 GO:44265 cellular macromolecule catabolic process 4.07E50 GO:70062 extracellular vesicular exosome 1.53E49 GO:43230 extracellular organelle 6.40E49 GO:65010 extracellular membrane-bounded organelle 6.40E49 GO:1901360 organic cyclic compound metabolic process 1.66E48 GO:43234 protein complex 9.14E47 GO:51179 localization 3.29E46 GO:6412 translation 3.94E45 GO:6139 nucleobase-containing compound metabolic process 6.37E45 GO:44765 single-organism transport 7.39E45 GO:6725 cellular aromatic compound metabolic process 1.36E44 GO:46483 heterocycle metabolic process 2.02E44 GO:6810 transport 1.09E43 GO:16023 cytoplasmic membrane-bounded vesicle 1.22E43 GO:51234 establishment of localization 1.39E43 GO:6950 response to stress 4.03E43 GO:31410 cytoplasmic vesicle 7.10E43 GO:3674 molecular_function 1.05E41 GO:22414 reproductive process 2.79E41 GO:3 reproduction 4.55E41 GO:22625 cytosolic large ribosomal subunit 6.24E41 GO:1901564 organonitrogen compound metabolic process 6.68E40 GO:65008 regulation of biological quality 2.85E39 GO:8150 biological_process 4.53E39 GO:3723 RNA binding 1.55E38 GO:31090 organelle membrane 5.16E38 GO:44085 cellular component biogenesis 1.31E37 GO:5739 mitochondrion 4.26E36 GO:48519 negative regulation of biological process 6.90E36 GO:50896 response to stimulus 9.53E36 GO:43170 macromolecule metabolic process 8.41E35 GO:19538 protein metabolic process 1.33E34 GO:9058 biosynthetic process 1.60E34 GO:48518 positive regulation of biological process 1.91E34 GO:42221 response to chemical stimulus 2.82E34 GO:6091 generation of precursor metabolites and energy 2.92E34 GO:6996 organelle organization 7.00E34 GO:1901576 organic substance biosynthetic process 1.24E33 GO:44267 cellular protein metabolic process 1.59E33 GO:22607 cellular component assembly 2.25E33 GO:22627 cytosolic small ribosomal subunit 2.29E33 GO:10467 gene expression 3.90E33 GO:48522 positive regulation of cellular process 9.45E33 GO:48523 negative regulation of cellular process 2.65E32 GO:44428 nuclear part 4.50E32 GO:5786 endoplasmic reticulum lumen 5.08E32 GO:10941 regulation of cell death 1.06E31 GO:1901135 carbohydrate derivative metabolic process 1.90E31 GO:43067 regulation of programmed cell death 2.42E31 GO:42961 regulation of apoptotic process 4.67E31 GO:65003 macromolecular complex assembly 7.55E31 GO:8219 cell death 1.01E30 GO:2478 antigen processing and presentation of exogenous peptide antigen 1.13E30 GO:16265 death 1.55E30 GO:5783 endoplasmic reticulum 2.16E30 GO:19884 antigen processing and presentation of exogenous antigen 2.36E30 GO:5840 ribosome 4.50E30 GO:48002 antigen processing and presentation of peptide antigen 4.87E30 GO:6082 organic acid metabolic process 6.10E30 GO:15934 large ribosomal subunit 6.56E30 GO:55114 oxidation-reduction process 6.89E30 GO:43436 oxoacid metabolic process 1.21E29 GO:44249 cellular biosynthetic process 1.46E29 GO:44260 cellular macromolecule metabolic process 1.92E29 GO:1901565 organonitrogen compound catabolic process 2.57E29 GO:3735 structural constituent of ribosome 3.22E29 GO:31981 nuclear lumen 9.80E29 GO:70887 cellular response to chemical stimulus 1.14E28 GO:19752 carboxylic acid metabolic process 1.39E28 GO:16070 RNA metabolic process 2.30E28 GO:2376 immune system process 3.98E28 GO:44421 extracellular region part 5.42E28 GO:51701 interaction with host 1.05E27 GO:44432 endoplasmic reticulum part 1.06E27 GO:5856 cytoskeleton 2.82E27 GO:51246 regulation of protein metabolic process 3.88E27 GO:55086 nucleobase-containing small molecule metabolic process 5.77E27 GO:10033 response to organic substance 8.11E27 GO:44419 interspecies interaction between organisms 1.16E26 GO:44403 symbiosis, encompassing mutualism through parasitism 1.16E26 GO:48610 cellular process involved in reproduction 1.49E26 GO:44707 single-multicellular organism process 1.76E26 GO:15980 energy derivation by oxidation of organic compounds 1.98E26 GO:32268 regulation of cellular protein metabolic process 2.06E26 GO:19048 virus-host interaction 4.98E26 GO:9117 nucleotide metabolic process 5.91E26 GO:44429 mitochondrial part 7.15E26 GO:90304 nucleic acid metabolic process 7.67E26 GO:6753 nucleoside phosphate metabolic process 1.43E25 GO:7599 hemostasis 2.09E25 GO:32501 multicellular organismal process 5.52E25 GO:65007 biological regulation 6.18E25 GO:31967 organelle envelope 1.01E24 GO:16044 cellular membrane organization 1.04E24 GO:16192 vesicle-mediated transport 1.63E24 GO:61024 membrane organization 1.97E24 GO:6521 regulation of cellular amino acid metabolic process 2.66E24 GO:2474 antigen processing and presentation of peptide antigen via MHC class I 4.07E24 GO:1901136 carbohydrate derivative catabolic process 4.47E24 GO:15935 small ribosomal subunit 4.47E24 GO:31975 envelope 5.21E24 GO:50817 coagulation 5.86E24 GO:7596 blood coagulation 5.86E24 GO:51128 regulation of cellular component organization 6.44E24 GO:5634 nucleus 1.10E23 GO:6457 protein folding 1.64E23 GO:5759 mitochondrial matrix 2.58E23 GO:30198 extracellular matrix organization 3.21E23 GO:43062 extracellular structure organization 3.57E23 GO:19882 antigen processing and presentation 4.64E23 GO:42060 wound healing 1.15E22 GO:50878 regulation of body fluid levels 2.65E22 GO:12505 endomembrane system 3.32E22 GO:42802 identical protein binding 3.74E22 GO:19637 organophosphate metabolic process 4.07E22 GO:6461 protein complex assembly 4.58E22 GO:70271 protein complex biogenesis 5.33E22 GO:33238 regulation of cellular amine metabolic process 1.01E21 GO:50789 regulation of biological process 1.02E21 GO:12501 programmed cell death 1.48E21 GO:51436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1.52E21 GO:6163 purine nucleotide metabolic process 3.11E21 GO:10608 posttranscriptional regulation of gene expression 3.26E21 GO:72413 signal transduction involved in mitotic cell cycle checkpoint 4.50E21 GO:72431 signal transduction involved in mitotic G1 DNA damage checkpoint 4.50E21 GO:6977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 4.50E21 GO:72401 signal transduction involved in DNA integrity checkpoint 6.36E21 GO:72422 signal transduction involved in DNA damage checkpoint 6.36E21 GO:72521 purine-containing compound metabolic process 6.79E21 GO:1901657 glycosyl compound metabolic process 7.55E21 GO:6915 apoptotic process 8.15E21 GO:51437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 8.83E21 GO:72395 signal transduction involved in cell cycle checkpoint 8.83E21 GO:30330 DNA damage response, signal transduction by p53 class mediator 1.01E20 GO:51443 positive regulation of ubiquitin-protein ligase activity 1.22E20 GO:9059 macromolecule biosynthetic process 1.40E20 GO:46128 purine ribonucleoside metabolic process 1.88E20 GO:42278 purine nucleoside metabolic process 2.12E20 GO:9150 purine ribonucleotide metabolic process 2.60E20 GO:19693 ribose phosphate metabolic process 2.60E20 GO:6417 regulation of translation 3.49E20 GO:51351 positive regulation of ligase activity 3.91E20 GO:51352 negative regulation of ligase activity 4.43E20 GO:51444 negative regulation of ubiquitin-protein ligase activity 4.43E20 GO:2479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP- 4.55E20 dependent GO:44433 cytoplasmic vesicle part 4.95E20 GO:72331 signal transduction by p53 class mediator 5.62E20 GO:51439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 5.98E20 GO:72523 purine-containing compound catabolic process 7.54E20 GO:44092 negative regulation of molecular function 7.54E20 GO:9259 ribonucleotide metabolic process 7.56E20 GO:19899 enzyme binding 8.81E20 GO:42590 antigen processing and presentation of exogenous peptide antigen via MHC class I 1.05E19 GO:44783 G1 DNA damage checkpoint 1.08E19 GO:31571 mitotic G1 DNA damage checkpoint 1.08E19 GO:9119 ribonucleoside metabolic process 1.19E19 GO:9611 response to wounding 1.38E19 GO:6195 purine nucleotide catabolic process 1.86E19 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 1.94E19 GO:9116 nucleoside metabolic process 1.95E19 GO:6152 purine nucleoside catabolic process 2.05E19 GO:46130 purine ribonucleoside catabolic process 2.05E19 GO:36094 small molecule binding 2.44E19 GO:42770 signal transduction in response to DNA damage 2.61E19 GO:44430 cytoskeletal part 3.07E19 GO:42454 ribonucleoside catabolic process 3.11E19 GO:71944 cell periphery 3.38E19 GO:43086 negative regulation of catalytic activity 3.86E19 GO:2576 platelet degranulation 4.41E19 GO:9164 nucleoside catabolic process 5.11E19 GO:48856 anatomical structure development 5.49E19 GO:71158 positive regulation of cell cycle arrest 5.77E19 GO:1901658 glycosyl compound catabolic process 6.25E19 GO:50794 regulation of cellular process 6.81E19 GO:51248 negative regulation of protein metabolic process 1.03E18 GO:32502 developmental process 1.05E18 GO:51716 cellular response to stimulus 1.12E18 GO:9166 nucleotide catabolic process 1.18E18 GO:9205 purine ribonucleoside triphosphate metabolic process 1.23E18 GO:32269 negative regulation of cellular protein metabolic process 1.31E18 GO:48731 system development 1.36E18 GO:9154 purine ribonucleotide catabolic process 1.40E18 GO:32270 positive regulation of cellular protein metabolic process 1.43E18 GO:9261 ribonucleotide catabolic process 1.45E18 GO:43168 anion binding 1.48E18 GO:9144 purine nucleoside triphosphate metabolic process 1.53E18 GO:9199 ribonucleoside triphosphate metabolic process 1.59E18 GO:34645 cellular macromolecule biosynthetic process 1.63E18 GO:1901292 nucleoside phosphate catabolic process 1.64E18 GO:51438 regulation of ubiquitin-protein ligase activity 1.67E18 GO:44773 mitotic DNA damage checkpoint 2.06E18 GO:31145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic 2.06E18 process GO:33554 cellular response to stress 2.39E18 GO:2000045 regulation of G1/S transition of mitotic cell cycle 3.48E18 GO:46434 organophosphate catabolic process 3.74E18 GO:5654 nucleoplasm 3.91E18 GO:51340 regulation of ligase activity 4.15E18 GO:43202 lysosomal lumen 4.56E18 GO:5975 carbohydrate metabolic process 4.84E18 GO:9141 nucleoside triphosphate metabolic process 4.84E18 GO:6986 response to unfolded protein 5.15E18 GO:44774 mitotic DNA integrity checkpoint 5.47E18 GO:35966 response to topologically incorrect protein 6.03E18 GO:10565 regulation of cellular ketone metabolic process 6.03E18 GO:31397 negative regulation of protein ubiquitination 6.34E18 GO:48471 perinuclear region of cytoplasm 7.05E18 GO:1901265 nucleoside phosphate binding 8.41E18 GO:5775 vacuolar lumen 1.45E17 GO:90 mitotic anaphase 1.55E17 GO:15629 actin cytoskeleton 1.74E17 GO:166 nucleotide binding 1.83E17 GO:31398 positive regulation of protein ubiquitination 1.96E17 GO:51322 anaphase 2.09E17 GO:16491 oxidoreductase activity 2.23E17 GO:9203 ribonucleoside triphosphate catabolic process 2.23E17 GO:9207 purine ribonucleoside triphosphate catabolic process 2.23E17 GO:9146 purine nucleoside triphosphate catabolic process 2.51E17 GO:9143 nucleoside triphosphate catabolic process 3.05E17 GO:45333 cellular respiration 3.05E17 GO:5886 plasma membrane 3.46E17 GO:87 M phase of mitotic cell cycle 4.52E17 GO:44770 cell cycle phase transition 5.24E17 GO:44772 mitotic cell cycle phase transition 5.24E17 GO:51247 positive regulation of protein metabolic process 7.30E17 GO:6458 de novo protein folding 9.71E17 GO:7275 multicellular organismal development 1.04E16 GO:502 proteasome complex 1.42E16 GO:2000602 regulation of interphase of mitotic cell cycle 1.42E16 GO:19866 organelle inner membrane 2.10E16 GO:43161 proteasomal ubiquitin-dependent protein catabolic process 2.17E16 GO:31966 mitochondrial membrane 2.20E16 GO:51259 protein oligomerization 2.85E16 GO:71156 regulation of cell cycle arrest 3.27E16 GO:5740 mitochondrial envelope 3.37E16 GO:10498 proteasomal protein catabolic process 3.39E16 GO:44271 cellular nitrogen compound biosynthetic process 3.57E16 GO:30168 platelet activation 3.67E16 GO:90068 positive regulation of cell cycle process 4.24E16 GO:279 M phase 5.00E16 GO:1901362 organic cyclic compound biosynthetic process 6.09E16 GO:5730 nucleolus 6.44E16 GO:278 mitotic cell cycle 6.78E16 GO:6006 glucose metabolic process 8.30E16 GO:9892 negative regulation of metabolic process 8.50E16 GO:34654 nucleobase-containing compound biosynthetic process 1.38E15 GO:51082 unfolded protein binding 1.60E15 GO:32879 regulation of localization 1.88E15 GO:5576 extracellular region 1.92E15 GO:22402 cell cycle process 2.13E15 GO:904 cell morphogenesis involved in differentiation 2.28E15 GO:44767 single-organism developmental process 2.78E15 GO:280 nuclear division 3.26E15 GO:7067 mitosis 3.26E15 GO:42803 protein homodimerization activity 3.30E15 GO:44724 single-organism carbohydrate catabolic process 3.96E15 GO:44093 positive regulation of molecular function 4.06E15 GO:209 protein polyubiquitination 4.93E15 GO:16052 carbohydrate catabolic process 6.89E15 GO:44723 single-organism carbohydrate metabolic process 7.22E15 GO:5743 mitochondrial inner membrane 8.83E15 GO:7049 cell cycle 9.62E15 GO:51084 de novo posttranslational protein folding 1.02E14 GO:71310 cellular response to organic substance 1.02E14 GO:34622 cellular macromolecular complex assembly 1.23E14 GO:84 S phase of mitotic cell cycle 1.27E14 GO:44437 vacuolar part 1.27E14 GO:5793 endoplasmic reticulum-Golgi intermediate compartment 1.32E14 GO:19438 aromatic compound biosynthetic process 1.39E14 GO:31396 regulation of protein ubiquitination 1.50E14 GO:51320 S phase 1.73E14 GO:31400 negative regulation of protein modification process 2.26E14 GO:31324 negative regulation of cellular metabolic process 2.34E14 GO:5773 vacuole 2.41E14 GO:30659 cytoplasmic vesicle membrane 2.82E14 GO:48285 organelle fission 3.14E14 GO:31325 positive regulation of cellular metabolic process 3.16E14 GO:5615 extracellular space 3.23E14 GO:6520 cellular amino acid metabolic process 3.96E14 GO:43167 ion binding 4.35E14 GO:18130 heterocycle biosynthetic process 5.13E14 GO:902 cell morphogenesis 6.14E14 GO:51129 negative regulation of cellular component organization 6.16E14 GO:31401 positive regulation of protein modification process 6.41E14 GO:6396 RNA processing 7.17E14 GO:82 G1/S transition of mitotic cell cycle 7.24E14 GO:9893 positive regulation of metabolic process 9.47E14 GO:5764 lysosome 1.27E13 GO:6928 cellular component movement 1.45E13 GO:8092 cytoskeletal protein binding 1.49E13 GO:44259 multicellular organismal macromolecule metabolic process 1.52E13 GO:8380 RNA splicing 1.52E13 GO:12506 vesicle membrane 1.60E13 GO:10605 negative regulation of macromolecule metabolic process 1.66E13 GO:323 lytic vacuole 1.84E13 GO:3729 mRNA binding 1.90E13 GO:5996 monosaccharide metabolic process 2.03E13 GO:46364 monosaccharide biosynthetic process 2.19E13 GO:3779 actin binding 2.20E13 GO:22617 extracellular matric disassembly 2.28E13 GO:10035 response to inorganic substance 2.35E13 GO:31012 extracellular matrix 3.04E13 GO:377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3.19E13 GO:398 mRNA splicing, via spliceosome 3.19E13 GO:1901991 negative regulation of mitotic cell cycle phase transition 3.52E13 GO:32963 collagen metabolic process 3.85E13 GO:7093 mitotic cell cycle checkpoint 3.86E13 GO:42645 mitochondrial nucleoid 4.70E13 GO:375 RNA splicing, via transesterification reactions 5.09E13 GO:16616 oxidoreductase activity, acting on the CHOH group of donors, NAD or NADP as acceptor 5.09E13 GO:16614 oxidoreductase activity, acting on CHOH group of donors 6.41E13 GO:9295 nucleoid 6.79E13 GO:65009 regulation of molecular function 6.89E13 GO:44236 multicellular organismal metabolic process 6.89E13 GO:51130 positive regulation of cellular component organization 7.06E13 GO:19318 hexose metabolic process 7.22E13 GO:5200 structural constituent of cytosketeton 8.23E13 GO:16020 membrane 9.24E13 GO:9653 anatomical structure morphogenesis 9.56E13 GO:30574 collagen catabolic process 9.67E13 GO:30029 actin filament-based process 1.05E12 GO:42175 nuclear outer membrane-endoplasmic reticulum membrane network 1.38E12 GO:43069 negative regulation of programmed cell death 1.49E12 GO:1775 cell activation 1.75E12 GO:43254 regulation of protein complex assembly 1.78E12 GO:77 DNA damage checkpoint 1.92E12 GO:50790 regulation of catalytic activity 2.00E12 GO:46983 protein dimerization activity 2.02E12 GO:32989 cellular component morphogenesis 2.17E12 GO:17111 nucleoside-triphosphatase activity 2.21E12 GO:42995 cell projection 2.48E12 GO:46365 monosaccharide catabolic process 2.72E12 GO:43085 positive regulation of catalytic activity 4.06E12 GO:5681 spliceosomal complex 4.31E12 GO:9986 cell surface 4.34E12 GO:44087 regulation of cellular component biogenesis 4.70E12 GO:31570 DNA integrity checkpoint 4.80E12 GO:31399 regulation of protein modification process 5.08E12 GO:44243 multicellular organismal catabolic process 5.08E12 GO:16462 pyrophosphatase activity 5.29E12 GO:51049 regulation of transport 5.76E12 GO:3824 catalytic activity 6.58E12 GO:22624 proteasome accessory complex 6.62E12 GO:18279 protein N-linked glycosylation via asparagine 7.02E12 GO:44420 extracellular matrix part 7.27E12 GO:5578 proteinaceous extracellular matrix 7.34E12 GO:32403 protein complex binding 7.34E12 GO:1901990 regulation of mitotic cell cycle phase transition 7.37E12 GO:7411 axon guidance 7.68E12 GO:5201 extracellular matrix structural constituent 7.72E12 GO:18196 peptidyl-asparagine modification 8.21E12 GO:16818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 8.29E12 GO:22613 ribonucleoprotein complex biogenesis 8.33E12 GO:60548 negative regulation of cell death 9.66E12 GO:32069 regulation of nuclease activity 9.69E12 GO:19320 hexose catabolic process 1.12E11 GO:43066 negative regulation of apoptotic process 1.26E11 GO:6007 glucose catabolic process 1.43E11 GO:16817 hydrolase activity, acting on acid anhydrides 1.44E11 GO:5938 cell cortex 1.62E11 GO:97159 organic cyclic compound binding 1.62E11 GO:1901066 guanosine-containing compound metabolic process 1.71E11 GO:9060 aerobic respiration 1.80E11 GO:6575 cellular modified amino acid metabolic process 1.85E11 GO:19886 antigen processing and presentation of exogenous peptide antigen via MHC class II 2.16E11 GO:32787 monocarboxylic acid metabolic process 2.19E11 GO:6397 mRNA processing 2.61E11 GO:6099 tricarboxylic acid cycle 2.63E11 GO:48199 vesicle targeting, to, from or within Golgi 2.68E11 GO:6987 activation of signaling protein activity involved in unfolded protein response 2.69E11 GO:48193 Golgi vesicle transport 2.72E11 GO:6081 cellular aldehyde metabolic process 3.22E11 GO:42743 hydrogen peroxide metabolic process 3.22E11 GO:48858 cell projection morphogenesis 3.36E11 GO:2495 antigen processing and presentation of peptide antigen via MHC class II 3.39E11 GO:30030 cell projection organization 3.51E11 GO:32774 RNA biosynthetic process 3.51E11 GO:33043 regulation of organelle organization 3.65E11 GO:32075 positive regulation of nuclease activity 4.14E11 GO:30968 endoplasmic reticulum unfolded protein response 4.25E11 GO:43603 cellular amide metabolic process 4.27E11 GO:30154 cell differentiation 4.42E11 GO:6984 ER-nucleus signaling pathway 4.53E11 GO:71013 catalytic step 2 spliceosome 4.63E11 GO:48667 cell morphogenesis involved in neuron differentiation 4.66E11 GO:1901363 heterocyclic compound binding 4.87E11 GO:16209 antioxidant activity 5.02E11 GO:22403 cell cycle phase 5.24E11 GO:32990 cell part morphogenesis 6.26E11 GO:5789 endoplasmic reticulum membrane 6.26E11 GO:5102 receptor binding 6.83E11 GO:48666 neuron development 7.55E11 GO:30036 actin cytoskeleton organization 9.08E11 GO:15630 microtubule cytoskeleton 9.52E11 GO:6487 protein N-linked glycosylation 1.07E10 GO:1901700 response to oxygen-containing compound 1.20E10 GO:72593 reactive oxygen species metabolic process 1.23E10 GO:7010 cytoskeleton organization 1.23E10 GO:34620 cellular response to unfolded protein 1.28E10 GO:51920 peroxiredoxin activity 1.35E10 GO:48468 cell development 1.42E10 GO:46039 GTP metabolic process 1.45E10 GO:6805 xenobiotic metabolic process 1.61E10 GO:6518 peptide metabolic process 1.67E10 GO:7409 axonogenesis 1.67E10 GO:10604 positive regulation of macromolecule metabolic process 1.75E10 GO:48583 regulation of response to stimulus 1.78E10 GO:71466 cellular response to xenobiotic stimulus 1.78E10 GO:48869 cellular developmental process 1.86E10 GO:32386 regulation of intracellular transport 1.87E10 GO:51329 interphase of mitotic cell cycle 1.87E10 GO:44712 single-organism catabolic process 1.96E10 GO:44282 small molecule catabolic process 1.96E10 GO:6901 vesicle coating 2.16E10 GO:22008 neurogenesis 2.20E10 GO:31175 neuron projection development 2.29E10 GO:51325 interphase 2.35E10 GO:6793 phosphorus metabolic process 2.44E10 GO:6732 coenzyme metabolic process 2.51E10 GO:16787 hydrolase activity 2.72E10 GO:9410 response to xenobiotic stimulus 3.05E10 GO:1901069 guanosine-containing compound catabolic process 3.20E10 GO:42592 homeostatic process 4.46E10 GO:34614 cellular response to reactive oxygen species 4.84E10 GO:6790 sulfur compound metabolic process 5.66E10 GO:16051 carbohydrate biosynthetic process 5.99E10 GO:6900 membrane budding 6.08E10 GO:30016 myofibril 6.27E10 GO:8064 regulation of actin polymerization or depolymerization 6.35E10 GO:30832 regulation of actin filament length 7.03E10 GO:32970 regulation of actin filament-based process 7.06E10 GO:48699 generation of neurons 7.12E10 GO:16050 vesicle organization 8.37E10 GO:48812 neuron projection morphogenesis 8.77E10 GO:6094 gluconeogenesis 8.91E10 GO:35967 cellular response to topologically incorrect protein 8.99E10 GO:19362 pyridine nucleotide metabolic process 8.99E10 GO:46496 nicotinamide nucleotide metabolic process 8.99E10 GO:1882 nucleoside binding 9.47E10 GO:3924 GTPase activity 9.63E10 GO:45087 innate immune response 1.07E09 GO:6184 GTP catabolic process 1.25E09 GO:17076 purine nucleotide binding 1.37E09 GO:30863 cortical cytoskeleton 1.58E09 GO:90066 regulation of anatomical structure size 1.60E09 GO:6446 regulation of translational initiation 1.84E09 GO:6629 lipid metabolic process 1.85E09 GO:32555 purine ribonucleotide binding 2.00E09 GO:43292 contractile fiber 2.05E09 GO:32940 secretion by cell 2.16E09 GO:5811 lipid particle 2.16E09 GO:32550 purine ribonucleoside binding 2.21E09 GO:19941 modification-dependent protein catabolic process 2.28E09 GO:6913 nucleocytoplasmic transport 2.29E09 GO:1883 purine nucleoside binding 2.29E09 GO:6903 vesicle targeting 2.44E09 GO:43632 modification-dependent macromolecule catabolic process 2.57E09 GO:32549 ribonucleoside binding 2.76E09 GO:32535 regulation of cellular component size 2.84E09 GO:22900 electron transport chain 2.91E09 GO:51169 nuclear transport 2.93E09 GO:6749 glutathione metabolic process 3.01E09 GO:7346 regulation of mitotic cell cycle 3.06E09 GO:72524 pyridine-containing compound metabolic process 3.06E09 GO:10564 regulation of cell cycle process 3.17E09 GO:35639 purine ribonucleoside triphosphate binding 3.42E09 GO:40011 locomotion 3.54E09 GO:42274 ribosomal small subunit biogenesis 3.54E09 GO:32553 ribonucleotide binding 3.56E09 GO:6887 exocytosis 3.65E09 GO:51168 cofactor metabolic process 3.74E09 GO:9719 response to endogenous stimulus 3.89E09 GO:23051 regulation of signaling 4.35E09 GO:52547 regulation of peptidase activity 4.56E09 GO:6112 energy reserve metabolic process 4.56E09 GO:42744 hydrogen peroxide catabolic process 4.60E09 GO:2504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 4.67E09 GO:1901988 negative regulation of cell cycle phase transition 4.68E09 GO:46903 secretion 4.73E09 GO:6508 proteolysis 4.83E09 GO:6511 ubiquitin-dependent protein catabolic process 5.14E09 GO:30833 regulation of actin filament polymerization 5.14E09 GO:35964 COPI-coated vesicle budding 5.17E09 GO:48205 COPI coating of Golgi vesicle 5.17E09 GO:48200 Golgi transport vesicle coating 5.17E09 GO:5178 integrin binding 5.33E09 GO:34599 cellular response to oxidative stress 6.28E09 GO:6979 response to oxidative stress 6.28E09 GO:70301 cellular response to hydrogen peroxide 6.65E09 GO:46034 ATP metabolic process 6.86E09 GO:6796 phosphate-containing compound metabolic process 7.41E09 GO:30834 regulation of actin filament depolymerization 7.55E09 GO:44257 cellular protein catabolic process 7.83E09 GO:75 cell cycle checkpoint 7.96E09 GO:42254 ribosome biogenesis 8.31E09 GO:10646 regulation of cell communication 8.45E09 GO:30139 endocytic vesicle 8.46E09 GO:50662 coenzyme binding 8.94E09 GO:22904 respiratory electron transport chain 9.17E09 GO:30182 neuron differentiation 9.24E09 GO:30017 sarcomere 9.24E09 GO:44700 single organism signaling 9.45E09 GO:23052 signaling 9.45E09 GO:7154 cell communication 9.75E09 GO:48194 Golgi vesicle budding 9.85E09 GO:34976 response to endoplasmic reticulum stress 1.01E08 GO:32271 regulation of protein polymerization 1.01E08 GO:44449 contractile fiber part 1.03E08 GO:1901701 cellular response to oxygen-containing compound 1.12E08 GO:5635 nuclear envelope 1.16E08 GO:19319 hexose biosynthetic process 1.22E08 GO:48513 organ development 1.25E08 GO:1901987 regulation of cell cycle phase transition 1.32E08 GO:51603 proteolysis involved in cellular protein catabolic process 1.33E08 GO:7399 nervous system development 1.42E08 GO:16054 organic acid catabolic process 1.42E08 GO:46395 carboxylic acid catabolic process 1.42E08 GO:6200 ATP catabolic process 1.43E08 GO:31252 cell leading edge 1.43E08 GO:6733 oxidoreduction coenzyme metabolic process 1.52E08 GO:19222 regulation of metabolic process 1.75E08 GO:9605 response to external stimulus 1.91E08 GO:10638 positive regulation of organelle organization 1.95E08 GO:51650 establishment of vesicle localization 2.15E08 GO:30199 collagen fibril organization 2.15E08 GO:42542 response to hydrogen peroxide 2.28E08 GO:48037 cofactor binding 2.29E08 GO:7044 cell-substrate junction assembly 2.40E08 GO:44273 sulfur compound catabolic process 2.48E08 GO:5604 basement membrane 2.51E08 GO:16684 oxidoreductase activity, acting on peroxide as acceptor 2.51E08 GO:4601 peroxidase activity 2.51E08 GO:1901137 carbohydrate derivative biosynthetic process 2.83E08 GO:30496 midbody 2.99E08 GO:30155 regulation of cell adhesion 2.99E08 GO:32956 regulation of actin cytoskeleton organization 3.05E08 GO:42127 regulation of cell proliferation 3.24E08 GO:51270 regulation of cellular component movement 3.31E08 GO:6952 defense response 3.56E08 GO:6897 endocytosis 3.59E08 GO:3988 acetyl-CoA C-acyltransferase activity 3.65E08 GO:7165 signal transduction 3.69E08 GO:30163 protein catabolic process 3.70E08 GO:51336 regulation of hydrolase activity 3.96E08 GO:16528 sarcoplasm 3.97E08 GO:16667 oxidoreductase activity, acting on a sulfur group of donors 4.02E08 GO:51693 actin filament capping 4.08E08 GO:302 response to reactive oxygen species 4.13E08 GO:22618 ribonucleoprotein complex assembly 4.64E08 GO:51493 regulation of cytoskeleton organization 4.80E08 GO:42330 taxis 4.80E08 GO:6935 chemotaxis 4.80E08 GO:42641 actomyosin 4.84E08 GO:6096 glycolysis 5.05E08 GO:60255 regulation of macromolecule metabolic process 5.40E08 GO:6739 NADP metabolic process 5.75E08 GO:1725 stress fiber 5.77E08 GO:19725 cellular homeostasis 5.78E08 GO:51726 regulation of cell cycle 6.18E08 GO:34329 cell junction assembly 6.71E08 GO:1525 angiogenesis 6.72E08 GO:6974 response to DNA damage stimulus 7.29E08 GO:22603 regulation of anatomical structure morphogenesis 7.40E08 GO:10948 negative regulation of cell cycle process 7.42E08 GO:5832 chaperonin-containing T-complex 7.84E08 GO:19901 protein kinase binding 8.03E08 GO:31406 carboxylic acid binding 8.03E08 GO:6921 cellular component disassembly involved in execution phase of apoptosis 8.10E08 GO:71826 ribonucleoprotein complex subunit organization 8.21E08 GO:19900 kinase binding 8.36E08 GO:48029 monosaccharide binding 8.78E08 GO:5794 Golgi apparatus 9.87E08 GO:51239 regulation of multicellular organismal process 9.88E08 GO:50661 NADP binding 9.88E08 GO:30120 vesicle coat 9.88E08 GO:60341 regulators of cellular localization 9.95E08 GO:31333 negative regulation of protein complex assembly 1.06E07 GO:30662 coated vesicle membrane 1.22E07 GO:5080 protein kinase C binding 1.25E07 GO:9888 tissue development 1.27E07 GO:2001233 regulation of apoptotic signaling pathway 1.38E07 GO:97194 execution phase of apoptosis 1.39E07 GO:5583 fibrillar collagen 1.47E07 GO:51235 maintenance of location 1.54E07 GO:48584 positive regulation of response to stimulus 1.63E07 GO:51656 establishment of organelle localization 1.66E07 GO:42383 sarcolemma 1.78E07 GO:30141 secretory granule 1.78E07 GO:34330 cell junction organization 1.89E07 GO:30835 negative regulation of actin filament depolymerization 1.92E07 GO:52548 regulation of endopeptidase activity 2.21E07 GO:1726 ruffle 2.27E07 GO:50793 regulation of developmental process 2.33E07 GO:15036 disulfide oxidoreductase activity 2.33E07 GO:80134 regulation of response to stress 2.37E07 GO:51287 NAD binding 2.50E07 GO:32432 actin filament bundle 2.54E07 GO:42026 protein refolding 2.63E07 GO:48585 negative regulation of response to stimulus 2.63E07 GO:44448 cell cortex part 2.93E07 GO:5516 calmodulin binding 2.93E07 GO:9055 electron carrier activity 2.93E07 GO:34660 ncRNA metabolic process 3.19E07 GO:51640 organelle localization 3.40E07 GO:31589 cell-substrate adhesion 3.47E07 GO:7015 actin filament organization 3.58E07 GO:16864 intramolecular oxidoreductase activity, transposing SS bonds 3.73E07 GO:3756 protein disulfide isomerase activity 3.73E07 GO:9966 regulation of signal transduction 3.76E07 GO:23057 negative regulation of signaling 4.15E07 GO:48407 platelet-derived growth factor binding 4.45E07 GO:44262 cellular carbohydrate metabolic process 4.45E07 GO:43687 post-translational protein modification 4.60E07 GO:35556 intracellular signal transduction 4.65E07 GO:10038 response to metal ion 5.16E07 GO:60314 regulation of ryanodine-sensitive calcium-release channel activity 5.22E07 GO:16862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups 5.22E07 GO:30490 maturation of SSU-rRNA 5.41E07 GO:9628 response to abiotic stimulus 5.59E07 GO:51087 chaperone binding 5.68E07 GO:10952 positive regulation of peptidase activity 5.74E07 GO:30137 COPI-coated vesicle 6.86E07 GO:6740 NADPH regeneration 6.86E07 GO:16887 ATPase activity 6.95E07 GO:51260 protein homooligomerization 7.13E07 GO:18193 peptidyl-amino acid modification 7.13E07 GO:30126 COPI vesicle coat 7.16E07 GO:34446 substrate adhesion-dependent cell spreading 8.63E07 GO:5525 GTP binding 8.65E07 GO:80090 regulation of primary metabolic process 8.86E07 GO:6027 glycosaminoglycan catabolic process 8.91E07 GO:97458 neuron part 9.20E07 GO:16860 intramolecular oxidoreductase activity 9.23E07 GO:9968 negative regulation of signal transduction 9.28E07 GO:1568 blood vessel development 9.58E07 GO:30663 COPI-coated vesicle membrane 9.68E07 GO:5509 calcium ion binding 1.16E06 GO:5874 microtubule 1.17E06 GO:10648 negative regulation of cell communication 1.19E06 GO:10942 positive regulation of cell death 1.21E06 GO:46930 pore complex 1.35E06 GO:51291 protein heterooligomerization 1.35E06 GO:32561 guanyl ribonucleotide binding 1.38E06 GO:1901698 response to nitrogen compound 1.39E06 GO:30334 regulation of cell migration 1.48E06 GO:44255 cellular lipid metabolic process 1.57E06 GO:43122 regulation of I-kappaB kinase/NF-kappaB cascade 1.57E06 GO:31347 regulation of defense response 1.59E06 GO:19001 guanyl nucleotide binding 1.64E06 GO:16408 C-acyltransferase activity 1.66E06 GO:33119 negative regulation of RNA splicing 1.66E06 GO:5581 collagen 1.73E06 GO:60205 cytoplasmic membrane-bounded vesicle lumen 1.78E06 GO:6909 phagocytosis 1.81E06 GO:7160 cell-matrix adhesion 1.86E06 GO:8022 protein C-terminus binding 1.86E06 GO:51262 protein tetramerization 1.89E06 GO:31983 vesicle lumen 2.03E06 GO:31323 regulation of cellular metabolic process 2.08E06 GO:42255 ribosome assembly 2.21E06 GO:32154 cleavage furrow 2.42E06 GO:15949 nucleobase-containing small molecule interconversion 2.42E06 GO:30135 coated vesicle 2.54E06 GO:10243 response to organic nitrogen 2.61E06 GO:44711 single-organism biosynthetic process 2.79E06 GO:3697 single-stranded DNA binding 2.79E06 GO:72359 circulatory system development 2.80E06 GO:72358 cardiovascular system development 2.80E06 GO:32272 negative regulation of protein polymerization 2.93E06 GO:30554 adenyl nucleotide binding 3.00E06 GO:8544 epidermis development 3.03E06 GO:6955 immune response 3.14E06 GO:51168 nuclear export 3.14E06 GO:1944 vasculature development 3.18E06 GO:51236 establisment of RNA localization 3.39E06 GO:50657 nucleic acid transport 3.39E06 GO:50658 RNA transport 3.39E06 GO:17148 negative regulation of translation 3.43E06 GO:2000145 regulation of cell motility 3.48E06 GO:30837 negative regulation of actin filament polymerization 3.49E06 GO:1901028 regulation of mitochondrial outer membrane permeabilization 3.60E06 GO:6364 rRNA processing 3.68E06 GO:22610 biological adhesion 3.69E06 GO:43005 neuron projection 3.85E06 GO:30660 Golgi-associated vesicle membrane 3.89E06 GO:22604 regulation of cell morphogenesis 3.94E06 GO:44283 small molecule biosynthetic process 4.02E06 GO:44459 plasma membrane part 4.04E06 GO:51050 positive regulation of transport 4.15E06 GO:72522 purine-containing compound biosynthetic process 4.17E06 GO:5798 Golgi-associated vesicle 4.18E06 GO:51289 protein homotetramerization 4.22E06 GO:16567 protein ubiquitination 4.25E06 GO:45859 regulation of protein kinase activity 4.28E06 GO:30666 endocytic vesicle membrane 4.62E06 GO:32559 adenyl ribonucleotide binding 4.67E06 GO:51648 vesicle localization 4.71E06 GO:19843 rRNA binding 4.92E06 GO:4857 enzyme inhibitor activity 5.22E06 GO:10821 regulation of mitochondrion organization 5.33E06 GO:43244 regulation of protein complex disassembly 5.65E06 GO:40012 regulation of locomotion 5.65E06 GO:6403 RNA localization 5.96E06 GO:16651 oxidoreductase activity, acting on NAD(P)H 5.96E06 GO:30512 negative regulation of transforming growth factor beta receptor signaling pathway 5.96E06 GO:6026 aminoglycan catabolic process 5.96E06 GO:9100 glycoprotein metabolic process 6.14E06 GO:5518 collagen binding 6.20E06 GO:42340 keratan sulfate catabolic process 6.42E06 GO:8143 poly(A) RNA binding 6.42E06 GO:2682 regulation of immune system process 6.54E06 GO:32153 cell division site 6.85E06 GO:32155 cell division site part 6.85E06 GO:8238 exopeptidase activity 6.90E06 GO:48514 blood vessel morphogenesis 7.01E06 GO:70647 protein modification by small protein conjugation or removal 7.09E06 GO:43549 regulation of kinase activity 7.11E06 GO:16072 rRNA metabolic process 7.30E06 GO:61134 peptidase regulator activity 7.39E06 GO:5905 coated pit 7.39E06 GO:16053 organic acid biosynthetic process 7.93E06 GO:46394 carboxylic acid biosynthetic process 7.93E06 GO:7155 cell adhesion 7.99E06 GO:31093 platelet alpha granule lumen 7.99E06 GO:1901879 regulation of protein depolymerization 8.23E06 GO:6098 pentose-phosphate shunt 8.47E06 GO:6890 retrograde vesicle-mediated transport, Golgi to ER 8.47E06 GO:10822 positive regulation of mitochondrion organization 9.36E06 GO:4364 glutathione transferase activity 9.36E06 GO:10627 regulation of intracellular protein kinase cascade 9.58E06 GO:15035 protein disulfide oxidoreductase activity 9.78E06 GO:43206 extracellular fibril organization 9.99E06 GO:97435 fibril organization 9.99E06 GO:48025 negative regulation of mRNA splicing, via spliceosome 9.99E06 GO:43065 positive regulation of apoptotic process 1.01E05 GO:6892 post-Golgi vesicle-mediated transport 1.01E05 GO:5782 peroxisomal matrix 1.03E05 GO:31907 microbody lumen 1.03E05 GO:6937 regulation of muscle contraction 1.04E05 GO:44242 cellular lipid catabolic process 1.07E05 GO:19003 GDP binding 1.08E05 GO:6144 purine nucleobase metabolic process 1.08E05 GO:16529 sarcoplasmic reticulum 1.10E05 GO:9112 nucleobase metabolic process 1.12E05 GO:70848 response to growth factor stimulus 1.19E05 GO:43068 positive regulation of programmed cell death 1.32E05 GO:51338 regulation of transferase activity 1.34E05 GO:16835 carbon-oxygen lyase activity 1.36E05 GO:19838 growth factor binding 1.38E05 GO:5524 ATP binding 1.41E05 GO:10880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1.44E05 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling 1.44E05 pathway GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic 1.44E05 signaling pathway GO:9165 nucleotide biosynthetic process 1.44E05 GO:30864 cortical actin cytoskeleton 1.45E05 GO:42451 purine nucleoside biosynthetic process 1.47E05 GO:46129 purine ribonucleoside biosynthetic process 1.47E05 GO:2000116 regulation of cysteine-type endopeptidase activity 1.50E05 GO:32446 protein modification by small protein conjugation 1.50E05 GO:15931 nucleobase-containing compound transport 1.52E05 GO:14070 response to organic cyclic compound 1.54E05 GO:55117 regulation of cardiac muscle contraction 1.56E05 GO:70925 organelle assembly 1.57E05 GO:90101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1.64E05 GO:28 ribosomal small subunit assembly 1.71E05 GO:462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.71E05 GO:4032 alditol: NADP + 1-oxidoreductase activity 1.71E05 GO:19322 pentose biosynthetic process 1.71E05 GO:51345 positive regulation of hydrolase activity 1.72E05 GO:8284 positive regulation of cell proliferation 1.80E05 GO:5885 Arp2/3 protein complex 1.83E05 GO:45785 positive regulation of cell adhesion 1.90E05 GO:60627 regulation of vesicle-mediated transport 1.97E05 GO:6164 purine nucleotide biosynthetic process 2.03E05 GO:32880 regulation of protein localization 2.14E05 GO:9068 aspartate family amino acid catabolic process 2.15E05 GO:70717 poly-purine tract binding 2.15E05 GO:50686 negative regulation of mRNA processing 2.15E05 GO:70482 response to oxygen levels 2.19E05 GO:71103 DNA conformation change 2.28E05 GO:1901293 nucleoside phosphate biosynthetic process 2.30E05 GO:70993 translation preinitiation complex 2.31E05 GO:33290 eukaryotic 48S preinitiation complex 2.31E05 GO:16282 eukaryotic 43S preinitiation complex 2.31E05 GO:31968 organelle outer membrane 2.49E05 GO:8135 translation factor activity, nucleic acid binding 2.49E05 GO:1901019 regulation of calcium ion transmembrane transporter activity 2.51E05 GO:5766 endosome 2.58E05 GO:6416 tRNA aminoacylation for protein translation 2.64E05 GO:43648 dicarboxylic acid metabolic process 2.68E05 GO:90288 negative regulation of cellular response to growth factor stimulus 2.68E05 GO:9152 purine ribonucleotide biosynthetic process 2.77E05 GO:43623 cellular protein complex assembly 2.83E05 GO:46390 ribose phosphate biosynthetic process 2.87E05 GO:35337 fatty-acyl-CoA metabolic process 2.90E05 GO:1731 formation of translation preinitiation complex 2.90E05 GO:8379 thioredoxin peroxidase activity 3.01E05 GO:35583 sequestering of TGFbeta in extracellular matrix 3.01E05 GO:19682 glyceraldehyde-3-phosphate metabolic process 3.01E05 GO:42776 mitochondrial ATP synthesis coupled proton transport 3.01E05 GO:3012 muscle system process 3.07E05 GO:60249 anatomical structure homeostasis 3.15E05 GO:43281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 3.22E05 GO:44548 S100 protein binding 3.25E05 GO:45727 positive regulation of translation 3.33E05 GO:51592 response to calcium ion 3.37E05 GO:19904 protein domain specific binding 3.37E05 GO:32388 positive regulation of intracellular transport 3.37E05 GO:55072 iron ion homeostasis 3.66E05 GO:30100 regulation of endocytosis 3.70E05 GO:34504 protein localization to nucleus 3.91E05 GO:31091 platelet alpha granule 4.11E05 GO:35338 long-chain fatty-acyl-CoA biosynthetic process 4.15E05 GO:72350 tricarboxylic acid metabolic process 4.15E05 GO:1901566 organonitrogen compound biosynthetic process 4.15E05 GO:51170 nuclear import 4.18E05 GO:5815 microtubule organizing center 4.29E05 GO:43039 tRNA aminoacylation 4.29E05 GO:43038 amino acid activation 4.29E05 GO:16197 endosomal transport 4.29E05 GO:2001242 regulation of intrinsic apoptotic signaling pathway 4.39E05 GO:71363 cellular response to growth factor stimulus 4.39E05 GO:4177 aminopeptidase activity 4.49E05 GO:3727 single-stranded RNA binding 4.61E05 GO:51301 cell division 4.94E05 GO:16853 isomerase activity 4.96E05 GO:6942 regulation of striated muscle contraction 4.96E05 GO:3008 system process 4.96E05 GO:34774 secretory granule lumen 5.19E05 GO:55082 cellular chemical homeostasis 5.23E05 GO:72329 monocarboxylic acid catabolic process 5.27E05 GO:10562 positive regulation of phosphorus metabolic process 5.46E05 GO:45937 positive regulation of phosphate metabolic process 5.46E05 GO:1666 response to hypoxia 5.46E05 GO:19798 procollagen-proline dioxygenase activity 5.54E05 GO:60316 positive regulation of ryanodine-sensitive calcium-release channel activity 5.56E05 GO:6554 lysine catabolic process 5.56E05 GO:6553 lysine metabolic process 5.56E05 GO:44438 microbody part 5.69E05 GO:44439 peroxisomal part 5.69E05 GO:90257 regulation of muscle system process 5.72E05 GO:5643 nuclear pore 5.72E05 GO:5813 centrosome 5.72E05 GO:35383 thioester metabolic process 5.96E05 GO:6637 acyl-CoA metabolic process 5.96E05 GO:17015 regulation of transforming growth factor beta receptor signaling pathway 6.01E05 GO:19867 outer membrane 6.10E05 GO:1901185 negative regulation of ERBB signaling pathway 6.19E05 GO:42059 negative regulation of epidermal growth factor receptor signaling pathway 6.19E05 GO:42579 microbody 6.23E05 GO:5777 peroxisome 6.23E05 GO:36293 response to decreased oxygen levels 6.28E05 GO:44431 Golgi apparatus part 6.34E05 GO:35384 thioester biosynthetic process 6.39E05 GO:71616 acyl-CoA biosynthetic process 6.39E05 GO:43021 ribonucleoprotein complex binding 6.50E05 GO:6611 protein export from nucleus 7.10E05 GO:2001257 regulation of cation channel activity 7.10E05 GO:43123 positive regulation of I-kappaB kinase/NF-kappaB cascade 7.13E05 GO:30133 transport vesicle 7.36E05 GO:6334 nucleosome assembly 7.54E05 GO:34399 nuclear periphery 7.92E05 GO:51271 negative regulation of cellular component movement 7.98E05 GO:50840 extracellular matrix binding 8.01E05 GO:51028 mRNA transport 8.47E05 GO:90287 regulation of cellular response to growth factor stimulus 8.47E05 GO:70402 NADPH binding 8.84E05 GO:60315 negative regulation of ryanodine-sensitive calcium-release channel activity 8.84E05 GO:4029 aldehyde dehydrogenase (NAD) activity 8.84E05 GO:16042 lipid catabolic process 8.84E05 GO:7052 mitotic spindle organization 9.18E05 GO:31941 filamentous actin 9.18E05 GO:9260 ribonucleotide biosynthetic process 9.27E05 GO:10881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 9.32E05 GO:90114 COPII-coated vesicle budding 9.32E05 GO:48208 COPII vesicle coating 9.32E05 GO:48207 vesicle targeting, rough ER to cis-Golgi 9.32E05 GO:46949 fatty-acyl-CoA biosynthetic process 9.32E05 GO:42325 regulation of phosphorylation 9.46E05 GO:10811 positive regulation of cell-substrate adhesion 9.72E05 GO:70201 regulation of establishment of protein localization 9.72E05 GO:51051 negative regulation of transport 9.81E05 GO:1901880 negative regulation of protein depolymerization 9.83E05 GO:33674 positive regulation of kinase activity 9.87E05 GO:50900 leukocyte migration 1.01E04 GO:2001056 positive regulation of cysteine-type endopeptidase activity 1.02E04 GO:16477 cell migration 1.03E04 GO:17038 protein import 1.03E04 GO:9051 pentose-phosphate shunt, oxidative branch 1.08E04 GO:43259 laminin-10 complex 1.08E04 GO:3985 acetly-CoA C-acetyltransferase activity 1.08E04 GO:30388 fructose 1,6-biphosphate metabolic process 1.08E04 GO:42455 ribonucleoside biosynthetic process 1.09E04 GO:31334 positive regulation of protein complex assembly 1.09E04 GO:45454 cell redox homeostasis 1.10E04 GO:6450 regulation of translational fidelity 1.18E04 GO:31543 peptidyl-proline dioxygenase activity 1.18E04 GO:55080 cation homeostasis 1.19E04 GO:48306 calcium-dependent protein binding 1.20E04 GO:45860 positive regulation of protein kinase activity 1.22E04 GO:30246 carbohydrate binding 1.25E04 GO:33764 steroid dehydrogenase activity, acting on the CHOH group of donors, NAD or NADP as acceptor 1.27E04 GO:51347 positive regulation of transferase activity 1.31E04 GO:70208 protein heterotrimerization 1.32E04 GO:51238 sequestering of metal ion 1.32E04 GO:1934 positive regulation of protein phosphorylation 1.32E04 GO:43242 negative regulation of protein complex disassembly 1.32E04 GO:10522 regulation of calcium ion transport into cytosol 1.32E04 GO:9066 aspartate family amino acid metabolic process 1.33E04 GO:33143 regulation of intracellular steroid hormone receptor signaling pathway 1.33E04 GO:44440 endosomal part 1.35E04 GO:4812 aminoacyl-tRNA ligase activity 1.37E04 GO:2000026 regulation of multicellular organismal development 1.39E04 GO:1932 regulation of protein phosphorylation 1.43E04 GO:35336 long-chain fatty-acyl-CoA metabolic process 1.48E04 GO:51279 regulation of release of sequestered calcium ion into cytosol 1.51E04 GO:3746 translation elongation factor activity 1.51E04 GO:16875 ligase activity, forming carbon-oxygen bonds 1.54E04 GO:16876 ligase activity, forming aminoacyl-tRNA and related compounds 1.54E04 GO:31497 chromatin assembly 1.55E04 GO:10950 positive regulation of endopeptidase activity 1.58E04 GO:32993 protein-DNA complex 1.58E04 GO:10951 negative regulation of endopeptidase activity 1.65E04 GO:71495 cellular response to endogenous stimulus 1.68E04 GO:44744 protein targeting to nucleus 1.68E04 GO:6606 protein import into nucleus 1.68E04 GO:44427 chromosomal part 1.70E04 GO:9163 nucleoside biosynthetic process 1.71E04 GO:1901659 glycosyl compound biosynthetic process 1.71E04 GO:6448 regulation of translational elongation 1.72E04 GO:30003 cellular cation homeostasis 1.75E04 GO:90092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1.78E04 GO:10810 regulation of cell-substrate adhesion 1.79E04 GO:42176 regulation of protein catabolic process 1.83E04 GO:6936 muscle contraction 1.83E04 GO:75733 intracellular transport of viral material 1.83E04 GO:910 cytokinesis 1.89E04 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 1.90E04 GO:9063 cellular amino acid catabolic process 1.90E04 GO:50764 regulation of phagocytosis 1.92E04 GO:6641 triglyceride metabolic process 1.94E04 GO:48878 chemical homeostasis 1.94E04 GO:16229 steroid dehydrogenase activity 1.99E04 GO:6839 mitochondrial transport 2.00E04 GO:2252 immune effector process 2.01E04 GO:5544 calcium-dependent phospholipid binding 2.07E04 GO:42327 positive regulation of phosphorylation 2.08E04 GO:9167 purine ribonucleoside monophosphate metabolic process 2.10E04 GO:6635 fatty acid beta-oxidation 2.10E04 GO:31253 cell projection membrane 2.11E04 GO:44463 cell projection part 2.15E04 GO:19321 pentose metabolic process 2.25E04 GO:5844 polysome 2.30E04 GO:9126 purine nucleoside monophosphate metabolic process 2.35E04 GO:30054 cell junction 2.37E04 GO:34728 nucleosome organization 2.39E04 GO:16836 hydro-lyase activity 2.41E04 GO:30162 regulation of proteolysis 2.41E04 GO:30117 membrane coat 2.42E04 GO:48475 coated membrane 2.42E04 GO:16453 C-acetyltransferase activity 2.47E04 GO:70934 CRD-mediated mRNA stabilization 2.47E04 GO:10649 regulation of cell communication by electrical coupling 2.47E04 GO:71692 protein localization to extracellular region 2.47E04 GO:71694 maintenance of protein location in extracellular region 2.47E04 GO:48027 mRNA 5-UTR binding 2.47E04 GO:2000425 regulation of apoptotic cell clearance 2.47E04 GO:3724 RNA helicase activity 2.62E04 GO:19371 cyclooxygenase pathway 2.62E04 GO:42178 xenobiotic catabolic process 2.62E04 GO:30207 chondroitin sulfate catabolic process 2.62E04 GO:5606 laminin-1 complex 2.62E04 GO:10466 negative regulation of peptidase activity 2.62E04 GO:8016 regulation of heart contraction 2.70E04 GO:6405 RNA export from nucleus 2.70E04 GO:30838 positive regulation of actin filament polymerization 2.70E04 GO:10882 regulation of cardiac muscle contraction by calcium ion signaling 2.71E04 GO:5753 mitochondrial proton-transporting ATP synthase complex 2.71E04 GO:42623 ATPase activity, coupled 2.71E04 GO:43280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 2.83E04 GO:9967 positive regulation of signal transduction 2.83E04 GO:1101 response to acid 2.83E04 GO:18149 peptide cross-linking 2.87E04 GO:90407 organophosphate biosynthetic process 2.88E04 GO:51651 maintenance of location in cell 2.94E04 GO:9206 purine ribonucleoside triphosphate biosynthetic process 2.96E04 GO:16765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3.00E04 GO:6639 acylglycerol metabolic process 3.00E04 GO:9145 purine nucleoside triphosphate biosynthetic process 3.18E04 GO:6873 cellular ion homeostasis 3.21E04 GO:6638 neutral lipid metabolic process 3.42E04 GO:9062 fatty acid catabolic process 3.49E04 GO:71451 cellular response to superoxide 3.53E04 GO:32964 collagen biosynthetic process 3.53E04 GO:19430 removal of superoxide radicals 3.53E04 GO:3857 3-hydroxyacyl-CoA dehydrogenase activity 3.53E04 GO:8106 alcohol dehydrogenase (NADP+) activity 3.53E04 GO:30934 anchoring collagen 3.53E04 GO:5694 chromosome 3.65E04 GO:6879 cellular iron ion homeostasis 3.66E04 GO:45185 maintenance of protein location 3.66E04 GO:86 G2/M transition of mitotic cell cycle 3.85E04 GO:16504 peptidase activator activity 3.87E04 GO:6754 ATP biosynthetic process 3.89E04 GO:33118 endoplasmic reticulum-Golgi intermediate compartment membrane 3.90E04 GO:19773 proteasome core complex, alpha-subunit complex 3.90E04 GO:5741 mitochondrial outer membrance 3.99E04 GO:9101 glycoprotein biosynthetic process 4.15E04 GO:48646 anatomical structure formation involved in morphogenesis 4.26E04 GO:97367 carbohydrate derivative binding 4.28E04 GO:6399 tRNA metabolic process 4.34E04 GO:6662 glycerol ether metabolic process 4.39E04 GO:6333 chromatin assembly or disassembly 4.43E04 GO:23056 positive regulation of signaling 4.48E04 GO:22898 regulation of transmembrane transporter activity 4.49E04 GO:51495 positive regulation of cytoskeleton organization 4.52E04 GO:34470 ncRNA processing 4.63E04 GO:50690 regulation of defense response to virus by virus 4.63E04 GO:35581 sequestering of extracellular ligand from receptor 4.63E04 GO:71437 invadopodium 4.63E04 GO:16508 long-chain-enoyl-CoA hydratase activity 4.63E04 GO:70937 CRD-mediated mRNA stability complex 4.63E04 GO:30235 nitric-oxide synthase regulator activity 4.63E04 GO:31581 hemidesmosome assembly 4.63E04 GO:2001258 negative regulation of cation channel activity 4.63E04 GO:46185 aldehyde catabolic process 4.63E04 GO:70003 threonine-type peptidase activity 4.68E04 GO:4298 threonine-type endopeptidase activity 4.68E04 GO:10647 positive regulation of cell communication 4.73E04 GO:9201 ribonucleoside triphosphate biosynthetic process 4.75E04 GO:6888 ER to Golgi vesicle-mediated transport 4.75E04 GO:139 Golgi membrane 4.84E04 GO:6631 fatty acid metabolic process 4.86E04 GO:32411 positive regulation of transporter activity 4.89E04 GO:5774 vacuolar membrane 4.94E04 GO:8283 cell proliferation 4.94E04 GO:65004 protein-DNA complex assembly 4.97E04 GO:5819 spindle 5.04E04 GO:55037 recycling endosome 5.10E04 GO:51272 positive regulation of cellular component movement 5.20E04 GO:51674 localization of cell 5.21E04 GO:50801 ion homeostasis 5.21E04 GO:48870 cell motility 5.21E04 GO:30203 glycosaminoglycan metabolic process 5.21E04 GO:97190 apoptotic signaling pathway 5.24E04 GO:43200 response to amino acid stimulus 5.37E04 GO:43531 ADP binding 5.38E04 GO:33144 negative regulation of intracellular steroid hormone receptor signaling pathway 5.38E04 GO:9897 external side of plasma membrane 5.43E04 GO:97193 intrinsic apoptotic signaling pathway 5.46E04 GO:1900117 regulation of execution phase of apoptosis 5.63E04 GO:30658 transport vesicle membrane 5.75E04 GO:8290 F-actin capping protein complex 5.93E04 GO:8250 oligosaccharyltransferase complex 5.93E04 GO:1900024 regulation of substrate adhesion-dependent cell spreading 5.93E04 GO:1901020 negative regulation of calcium ion transmembrane transporter activity 5.93E04 GO:51131 chaperone-mediated protein complex assembly 5.93E04 GO:42288 MHC class I protein binding 5.93E04 GO:7051 spindle organization 6.10E04 GO:9725 response to hormone stimulus 6.14E04 GO:44766 multi-organism transport 6.28E04 GO:72512 trivalent inorganic cation transport 6.28E04 GO:33572 transferrin transport 6.28E04 GO:15682 ferric iron transport 6.28E04 GO:16655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 6.34E04 GO:16829 lyase activity 6.38E04 GO:6308 DNA catabolic process 6.84E04 GO:43022 ribosome binding 6.86E04 GO:50776 regulation of immune response 7.10E04 GO:10639 negative regulation of organelle organization 7.12E04 GO:43413 macromolecule glycosylation 7.19E04 GO:6466 protein glycosylation 7.19E04 GO:5839 proteasome core complex 7.27E04 GO:5852 eukaryotic translation initiation factor 3 complex 7.27E04 GO:30866 cortical actin cytoskeleton organization 7.31E04 GO:786 nucleosome 7.32E04 GO:2161 aminoacyl-tRNA editing activity 7.53E04 GO:70419 nonhomologous end joining complex 7.61E04 GO:8429 phosphatidylethanolamine binding 7.61E04 GO:5589 collagen type VI 7.61E04 GO:6101 citrate metabolic process 7.61E04 GO:15037 peptide disulfide oxidoreductase activity 7.61E04 GO:43488 regulation of mRNA stability 7.62E04 GO:9142 nucleoside triphosphate biosynthetic process 7.77E04 GO:32273 positive regulation of protein polymerization 7.84E04 GO:2684 positive regulation of immune system process 7.87E04 GO:10008 endosome membrane 8.26E04 GO:45807 positive regulation of endocytosis 8.26E04 GO:1937 negative regulation of endothelial cell proliferation 8.44E04 GO:42339 keratan sulfate metabolic process 8.44E04 GO:45121 membrane raft 8.48E04 GO:10563 negative regulation of phosphorus metabolic process 8.73E04 GO:45936 negative regulation of phosphate metabolic process 8.73E04 GO:32409 regulation of transposer activity 8.76E04 GO:9108 coenzyme biosynthetic process 8.76E04 GO:2253 activation of immune response 8.78E04 GO:30336 negative regulation of cell migration 8.79E04 GO:6875 cellular metal ion homeostasis 9.08E04 GO:40013 negative regulation of locomotion 9.14E04 GO:33673 negative regulation of kinase activity 9.18E04 GO:51924 regulation of calcium ion transport 9.20E04 GO:30705 cytoskeleton-dependent intracellular transport 9.26E04 GO:43256 laminin complex 9.32E04 GO:19471 4-hydroxyproline metabolic process 9.32E04 GO:1901021 positive regulation of calcium ion transmembrane transporter activity 9.32E04 GO:42273 ribosomal large subunit biogenesis 9.32E04 GO:6103 2-oxoglutarate metabolic process 9.32E04 GO:7009 plasma membrane organization 9.57E04 GO:51099 positive regulation of binding 9.80E04 GO:2000146 negative regulation of cell motility 1.01E03 GO:44325 ion channel binding 1.01E03 GO:1901605 alpha-amino acid metabolic process 1.03E03 GO:44070 regulation of anion transport 1.04E03 GO:70085 glycosylation 1.06E03 GO:6022 aminoglycan metabolic process 1.08E03 GO:5884 actin filament 1.09E03 GO:10740 positive regulation of intracellular protein kinase cascade 1.10E03 GO:70206 protein trimerization 1.11E03 GO:31418 L-ascorbic acid binding 1.11E03 GO:30865 cortical cytoskeleton organization 1.11E03 GO:5911 cell-cell junction 1.13E03 GO:42493 response to drug 1.13E03 GO:18904 ether metabolic process 1.14E03 GO:45022 early endosome to late endosome transport 1.15E03 GO:5836 proteasome regulatory particle 1.15E03 GO:5853 eukaryotic translation elongation factor 1 complex 1.15E03 GO:43024 ribosomal small subunit binding 1.15E03 GO:44597 daunorubicin metabolic process 1.15E03 GO:44598 doxorubicin metabolic process 1.15E03 GO:44183 protein binding involved in protein folding 1.15E03 GO:51016 barbed-end actin filament capping 1.15E03 GO:30647 aminoglycoside antibiotic metabolic process 1.15E03 GO:4300 enoyl-CoA hydratase activity 1.15E03 GO:75713 establishment of integrated proviral latency 1.15E03 GO:15266 porin activity 1.15E03 GO:46487 glyoxylate metabolic process 1.15E03 GO:51015 actin filament binding 1.16E03 GO:43484 regulation of RNA splicing 1.17E03 GO:4866 endopeptidase inhibitor activity 1.20E03 GO:71824 protein-DNA complex subunit organization 1.20E03 GO:10975 regulation of neuron projection development 1.21E03 GO:19897 extrinsic to plasma membrane 1.22E03 GO:35637 multicellular organsimal signaling 1.22E03 GO:61136 regulation of proteasomal protein catabolic process 1.23E03 GO:19903 protein phosphatase binding 1.23E03 GO:8144 drug binding 1.23E03 GO:61383 trabecula morphogenesis 1.24E03 GO:33017 sarcoplasmic reticulum membrane 1.25E03 GO:5605 basal lamina 1.25E03 GO:50688 regulation of defense response to virus 1.25E03 GO:42058 regulation of epidermal growth factor receptor signaling pathway 1.25E03 GO:16705 oxidoreductase activity, acting on paired donors, with incorporation of reduction of molecular 1.27E03 oxygen GO:31344 regulation of cell projection organization 1.28E03 GO:52632 citrate hydro-lyase (cis-aconitate-forming) activity 1.30E03 GO:52633 isocitrate hydro-lyase (cis-aconitate-forming) activity 1.30E03 GO:70288 ferritin complex 1.30E03 GO:461 endonucleolytic cleavage to generate mature 3-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, 1.30E03 LSU-rRNA) GO:35613 RNA stem-loop binding 1.30E03 GO:17098 sulfonylurea receptor binding 1.30E03 GO:2135 CTP binding 1.30E03 GO:2580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC 1.30E03 class II GO:10501 RNA secondary structure unwinding 1.30E03 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction 1.30E03 GO:5584 collagen type I 1.30E03 GO:5999 xylulose biosynthetic process 1.30E03 GO:6097 glyoxylate cycle 1.30E03 GO:5642 annulate lamellae 1.30E03 GO:6880 intracellular sequestering of iron ion 1.30E03 GO:2001135 regulation of endocytic recycling 1.30E03 GO:2001137 positive regulation of endocytic recycling 1.30E03 GO:31372 UBC13-MMS2 complex 1.30E03 GO:8043 intracellular ferritin complex 1.30E03 GO:43524 negative regulation of neuron apoptotic process 1.32E03 GO:1901184 regulation of ERBB signaling pathway 1.33E03 GO:50778 positive regulation of immune response 1.35E03 GO:43487 regulation of RNA stability 1.35E03 GO:9063 branched-chain amino acid catabolic process 1.36E03 GO:4033 aldo-keto reductase (NADP) activity 1.36E03 GO:44297 cell body 1.36E03 GO:61135 endopeptidase regulator activity 1.37E03 GO:43588 skin development 1.44E03 GO:31674 I band 1.45E03 GO:5765 lysosomal membrane 1.45E03 GO:8202 steroid metabolic process 1.46E03 GO:6469 negative regulation of protein kinase activity 1.46E03 GO:2831 regulation of response to biotic stimulus 1.46E03 GO:15662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1.47E03 GO:6323 DNA packaging 1.51E03 GO:7229 integrin-mediated signaling pathway 1.51E03 GO:55065 metal ion homeostasis 1.54E03 GO:32412 regulation of ion transmembrane transporter activity 1.55E03 GO:30027 lamellipodium 1.57E03 GO:9890 negative regulation of biosynthetic process 1.59E03 GO:43171 peptide catabolic process 1.63E03 GO:33018 sarcoplasmic reticulum lumen 1.63E03 GO:50786 RAGE receptor binding 1.63E03 GO:303 response to superoxide 1.63E03 GO:1516 prostaglandin biosynthetic process 1.63E03 GO:46457 prostanoid biosynthetic process 1.63E03 GO:97202 activation of cysteine-type endopeptidase activity 1.65E03 GO:32508 DNA duplex unwinding 1.65E03 GO:16620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as 1.65E03 acceptor GO:6767 water-soluble vitamin metabolic process 1.65E03 GO:70161 anchoring junction 1.66E03 GO:45595 regulation of cell differentiation 1.66E03 GO:51348 negative regulation of transferase activity 1.68E03 GO:9615 response to virus 1.68E03 GO:30414 peptidase inhibitor activity 1.69E03 GO:34097 response to cytokine stimulus 1.72E03 GO:785 chromatin 1.73E03 GO:31256 leading edge membrane 1.74E03 GO:32414 positive regulation of ion transmembrane transporter activity 1.76E03 GO:45259 proton-transporting ATP synthase complex 1.76E03 GO:71705 nitrogen compound transport 1.77E03 GO:19395 fatty acid oxdation 1.77E03 GO:31547 regulation of protein stability 1.81E03 GO:32392 DNA geometric change 1.85E03 GO:7162 negative regulation of cell adhesion 1.85E03 GO:34440 lipid oxidation 1.90E03 GO:8015 blood circulation 1.91E03 GO:30506 ankyrin binding 1.93E03 GO:7517 muscle organ development 1.96E03 GO:30262 apoptotic nuclear changes 1.97E03 GO:7568 aging 2.02E03 GO:10959 regulation of metal ion transport 2.05E03 GO:1901215 negative regulation of neuron death 2.07E03 GO:3013 circulatory system process 2.07E03 GO:16903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.07E03 GO:33293 monocarboxylic acid binding 2.08E03 GO:16597 amino acid binding 2.16E03 GO:42277 peptide binding 2.17E03 GO:38127 ERBB signaling pathway 2.17E03 GO:34332 adherens junction organization 2.18E03 GO:8233 peptidase activity 2.18E03 GO:8289 lipid binding 2.18E03 GO:34333 adherens junction assembly 2.20E03 GO:48024 regulation of mRNA splicing, via spliceosome 2.20E03 GO:15985 energy coupled proton transport, down electrochemical gradient 2.20E03 GO:15986 ATP synthesis coupled proton transport 2.20E03 GO:16417 S-acyltransferase activity 2.21E03 GO:10592 positive regulation of lamellipodium assembly 2.21E03 GO:19043 establishment of viral latency 2.21E03 GO:6011 UDP-glucose metabolic process 2.21E03 GO:5652 nuclear lamina 2.21E03 GO:8091 spectrin 2.21E03 GO:50684 regulation of mRNA processing 2.25E03 GO:34080 CENP-A containing nucleosome assembly at centromere 2.26E03 GO:34724 DNA replication-independent nucleosome organization 2.26E03 GO:34308 primary alcohol metabolic process 2.26E03 GO:6336 DNA replication-independent nucleosome assembly 2.26E03 GO:32413 negative regulation of ion transmembrane transporter activity 2.26E03 GO:18208 peptidyl-proline modification 2.30E03 GO:19898 extrinsic to membrane 2.32E03 GO:61061 muscle structure development 2.33E03 GO:2433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 2.41E03 GO:38094 Fc-gamma receptor signaling pathway 2.41E03 GO:38096 Fc-gamma receptor signaling pathway involved in phagocytosis 2.41E03 GO:30018 Z disc 2.42E03 GO:47485 protein N-terminus bindng 2.43E03 GO:6766 vitamin metabolic process 2.43E03 GO:16363 nuclear matrix 2.43E03 GO:6090 pyruvate metabolic process 2.43E03 GO:5912 adherens junction 2.43E03 GO:30335 positive regulation of cell migration 2.51E03 GO:51494 negative regulation of cytoskeleton organization 2.57E03 GO:33218 amide binding 2.60E03 GO:2431 Fc receptor mediated stimulatory signaling pathway 2.60E03 GO:4003 ATP-dependent DNA helicase activity 2.63E03 GO:2001259 positive regulation of cation channel activity 2.64E03 GO:42326 negative regulation of phosphorylation 2.65E03 GO:45806 negative regulation of endocytosis 2.70E03 GO:10769 regulation of cell morphogenesis involved in differentiation 2.72E03 GO:10720 positive regulation of cell development 2.72E03 GO:70011 peptidase activity, acting on L-amino acid peptides 2.76E03 GO:19226 transmission of nerve impulse 2.77E03 GO:9161 ribonucleoside monophosphate metabolic process 2.79E03 GO:71229 cellular response to acid 2.79E03 GO:48678 response to axon injury 2.79E03 GO:32434 regulation of proteasomal ubiquitin-dependent protein catabolic process 2.79E03 GO:43523 regulation of neuron apoptotic process 2.80E03 GO:71230 cellular response to amino acid stimulus 2.84E03 GO:38093 Fc receptor signaling pathway 2.90E03 GO:43295 glutathione binding 2.90E03 GO:51409 response to nitrosative stress 2.90E03 GO:1846 complement binding 2.90E03 GO:17166 vinculin binding 2.90E03 GO:1900750 oligopeptide binding 2.90E03 GO:33483 gas homeostasis 2.90E03 GO:19042 viral latency 2.90E03 GO:6102 isocitrate metabolic process 2.90E03 GO:6069 ethanol oxidation 2.90E03 GO:6610 ribosomal protein import into nucleus 2.90E03 GO:6189 de novo IMP biosynthetic process 2.90E03 GO:31904 endosome lumen 2.90E03 GO:2000147 positive regulation of cell motility 2.93E03 GO:51017 actin filament bundle assembly 2.95E03 GO:43034 costamere 3.03E03 GO:42162 telomeric DNA binding 3.03E03 GO:8285 negative regulation of cell proliferation 3.09E03 GO:1901699 cellular response to nitrogen compound 3.10E03 GO:7163 establishment of maintenance of cell polarity 3.10E03 GO:6826 iron ion transport 3.14E03 GO:30234 enzyme regulator activity 3.14E03 GO:71248 cellular response to metal ion 3.14E03 GO:45335 phagocytic vesicle 3.14E03 GO:30674 protein binding, bridging 3.22E03 GO:51346 negative regulation of hydrolase activity 3.23E03 GO:1556 regulation of cell growth 3.26E03 GO:71277 cellular response to calcium ion 3.27E03 GO:44455 mitochondrial membrane part 3.33E03 GO:51020 GTPase binding 3.41E03 GO:70458 cellular detoxification of nitrogen compound 3.41E03 GO:9169 purine ribonucleoside monophosphate catabolic process 3.41E03 GO:9158 ribonucleoside monophosphate catabolic process 3.41E03 GO:43200 laminin-11 complex 3.41E03 GO:71438 invadopodium membrane 3.41E03 GO:16672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as 3.41E03 acceptor GO:1884 pyrimidine nucleoside binding 3.41E03 GO:2134 UTP binding 3.41E03 GO:19797 procollagen-proline 3-dioxygenase activity 3.41E03 GO:10716 negative regulation of extracellular matrix disassembly 3.41E03 GO:33484 nitric oxide homeostasis 3.41E03 GO:18636 phenanthrene 9,10-monooxygenase activity 3.41E03 GO:18916 nitrobenzene metabolic process 3.41E03 GO:1901741 positive regulation of myoblast fusion 3.41E03 GO:3994 aconitate hydratase activity 3.41E03 GO:47718 indanol dehydrogenase activity 3.41E03 GO:6106 fumarate metabolic process 3.41E03 GO:6065 UDP-glucuronate biosynthetic process 3.41E03 GO:32557 pyrimidine ribonucleotide binding 3.41E03 GO:32551 pyrimidine ribonucleoside binding 3.41E03 GO:31838 haptoglobin-hemoglobin complex 3.41E03 GO:31544 peptidyl-proline 3-dioxygenase activity 3.41E03 GO:47086 ketosteroid monooxygenase activity 3.41E03 GO:15853 adenine transport 3.41E03 GO:31125 rRNA 3-end processing 3.41E03 GO:43277 apoptotic cell clearance 3.43E03 GO:17134 fibroblast growth factor binding 3.43E03 GO:5523 tropomyosin binding 3.43E03 GO:6188 IMP biosynthetic process 3.43E03 GO:31055 chromatin remodeling at centromere 3.43E03 GO:1523 retinoid metabolic process 3.47E03 GO:16706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular 3.47E03 oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:3678 DNA helicase activity 3.47E03 GO:8308 voltage-gated anion channel activity 3.53E03 GO:36296 response to increased oxygen levels 3.53E03 GO:35872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 3.53E03 GO:55093 response to hyperoxia 3.53E03 GO:19902 phosphatase binding 3.54E03 GO:1901681 sulfur compound binding 3.56E03 GO:8536 Ran GTPase binding 3.65E03 GO:16461 unconventional myosin complex 3.65E03 GO:19652 L-ascorbic acid metabolic process 3.65E03 GO:34310 primary alcohol catabolic process 3.65E03 GO:32456 endocytic recycling 3.65E03 GO:31996 thioesterase binding 3.65E03 GO:43169 cation binding 3.66E03 GO:6687 glycosphingolipid metabolic process 3.66E03 GO:71417 cellular response to organic nitrogen 3.72E03 GO:42625 ATPase activity, coupled to transmembrane movement of ions 3.84E03 GO:7167 enzyme linked receptor protein signaling pathway 3.90E03 GO:43489 RNA stabilization 3.91E03 GO:51764 actin crosslink formation 3.91E03 GO:2102 podosome 3.91E03 GO:30127 COPII vesicle coat 3.91E03 GO:48255 mRNA stabilization 3.91E03 GO:46040 IMP metabolic process 3.91E03 GO:40017 positive regulation of locomotion 3.93E03 GO:9991 response to extracellular stimulus 3.96E03 GO:42445 hormone metabolic process 4.02E03 GO:71241 cellular response to inorganic substance 4.16E03 GO:33993 response to lipid 4.17E03 GO:90382 phagosome maturation 4.24E03 GO:723 telomere maintenance 4.28E03 GO:5977 glycogen metabolic process 4.28E03 GO:31123 RNA 3-end processing 4.37E03 GO:31345 negative regulation of cell projection organization 4.39E03 GO:43269 regulation of ion transport 4.39E03 GO:1901214 regulation of neuron death 4.44E03 GO:51059 NF-kappaB binding 4.45E03 GO:34314 Arp2/3 complex-mediated actin nucleation 4.45E03 GO:45182 translation regulator activity 4.45E03 GO:60284 regulation of cell development 4.53E03 GO:44042 glucan metabolic process 4.57E03 GO:72341 modified amino acid binding 4.57E03 GO:30048 actin filament-based movement 4.57E03 GO:6073 cellular glucan metabolic process 4.57E03 GO:32200 telomere organization 4.57E03 GO:51094 positive regulation of developmental process 4.57E03 GO:36295 cellular response to increased oxygen levels 4.57E03 GO:71455 cellular response to hyperoxia 4.57E03 GO:60346 bone trabecula formation 4.57E03 GO:50765 negative regulation of phagocytosis 4.57E03 GO:30214 hyaluronan catabolic process 4.57E03 GO:7268 synaptic transmission 4.69E03 GO:51188 cofactor biosynthetic process 4.69E03 GO:5539 glycosaminoglycan binding 4.69E03 GO:31346 positive regulation of cell projection organization 4.69E03 GO:51092 positive regulation of NF-kappaB transcription factor activity 4.77E03 GO:44264 cellular polysaccharide metabolic process 4.85E03 GO:16101 diterpenoid metabolic process 4.85E03 GO:1676 long-chain fatty acid metabolic process 5.01E03 GO:45010 actin nucleation 5.01E03 GO:51881 regulation of mitochondrial membrane potential 5.01E03 GO:5916 fascia adherens 5.01E03 GO:9168 purine ribonucleoside monophosphate biosynthetic process 5.01E03 GO:9127 purine nucleoside monophosphate biosynthetic process 5.01E03 GO:19432 triglyceride biosynthetic process 5.01E03 GO:3684 damaged DNA binding 5.24E03 GO:51174 regulation of phosphorus metabolic process 5.28E03 GO:45111 intermediate filament cytoskeleton 5.30E03 GO:6919 activation of cysteine-type endopeptidase activity involved in apoptotic process 5.41E03 GO:6944 cellular membrane fusion 5.41E03 GO:43900 regulation of multi-organism process 5.47E03 GO:7040 lysosome organization 5.47E03 GO:16469 proton-transporting two-sector ATPase complex 5.48E03 GO:90316 positive regulation of intracellular protein transport 5.48E03 GO:10558 negative regulation of macromolecule biosynthetic process 5.56E03 GO:8360 regulation of cell shape 5.57E03 GO:1901615 organic hydroxy compound metabolic process 5.58E03 GO:18401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 5.63E03 GO:90136 epithelial cell-cell adhesion 5.63E03 GO:5719 nuclear euchromatin 5.63E03 GO:16137 glycoside metabolic process 5.63E03 GO:31258 lamellipodium membrane 5.63E03 GO:9081 branched-chain amino acid metabolic process 5.63E03 GO:43466 histone exchange 5.63E03 GO:48365 Rac GTPase binding 5.63E03 GO:32410 negative regulation of transporter activity 5.63E03 GO:4197 cysteine-type endopeptidase activity 5.69E03 GO:44769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 5.91E03 GO:46463 acylglycerol biosynthetic process 5.91E03 GO:46460 neutral lipid biosynthetic process 5.91E03 GO:45216 cell-cell junction organization 5.94E03 GO:31327 negative regulation of cellular biosynthetic process 6.05E03 GO:44389 small conjugating protein ligase binding 6.12E03 GO:31625 uibiquitin protein ligase binding 6.12E03 GO:71345 cellular response to cytokine stimulus 6.15E03 GO:34754 cellular hormone metabolic process 6.19E03 GO:447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from 6.19E03 tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:478 endonucleolytic cleavage involved in rRNA processing 6.19E03 GO:479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.19E03 GO:469 cleavage involved in rRNA processing 6.19E03 GO:9128 purine nucleoside monophosphate catabolic process 6.19E03 GO:70061 fructose binding 6.19E03 GO:8426 protein kinase C inhibitor activity 6.19E03 GO:9753 response to jasmonic acid stimulus 6.19E03 GO:45040 protein import into mitochondrial outer membrane 6.19E03 GO:51683 establishment of Golgi localization 6.19E03 GO:51208 sequestering of calcium ion 6.19E03 GO:36021 endolysosome lumen 6.19E03 GO:71395 cellular response to jasmonic acid stimulus 6.19E03 GO:34205 beta-amyloid formation 6.19E03 GO:1901739 regulation of myoblast fusion 6.19E03 GO:47115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 6.19E03 GO:90502 RNA phosphodiester bond hydrolysis, endonucleolytic 6.19E03 GO:5997 xylulose metabolic process 6.19E03 GO:5862 muscle thin filament tropomyosin 6.19E03 GO:7161 calcium-independent cell-matrix adhesion 6.19E03 GO:45252 oxoglutarate dehydrogenase complex 6.19E03 GO:7008 outer mitochondrial membrane organization 6.19E03 GO:47023 androsterone dehydrogenase activity 6.19E03 GO:46294 formaldehyde catabolic process 6.19E03 GO:46398 UDP-glucuronate metabolic process 6.19E03 GO:17025 TBP-class protein binding 6.23E03 GO:6309 apoptotic DNA fragmentation 6.23E03 GO:6906 vesicle fusion 6.23E03 GO:60090 binding, bridging 6.23E03 GO:7173 epidermal growth factor receptor signaling pathway 6.46E03 GO:61025 membrane fusion 6.54E03 GO:2757 immune response-activating signal transduction 6.65E03 GO:8565 protein transporter activity 6.65E03 GO:16801 hydrolase activity, acting on ether bonds 6.71E03 GO:51196 regulation of coenzyme metabolic process 6.71E03 GO:51193 regulation of cofactor metabolic process 6.71E03 GO:97066 response to thyroid hormone stimulus 6.71E03 GO:42136 neurotransmitter biosynthetic process 6.71E03 GO:4656 procollagen-proline 4-dioxygenase activity 6.71E03 GO:14912 negative regulation of smooth muscle cell migration 6.71E03 GO:10770 positive regulation of cell morphogenesis involved in differentiation 6.82E03 GO:737 DNA catabolic process, endonucleolytic 6.94E03 GO:34508 centromere complex assembly 6.94E03 GO:6693 prostaglandin metabolic process 6.94E03 GO:6692 prostanoid metabolic process 6.94E03 GO:8186 RNA-dependent ATPase activity 6.94E03 GO:46209 nitric oxide metabolic process 6.94E03 GO:5901 caveola 6.98E03 GO:9607 response to biotic stimulus 7.01E03 GO:30055 cell-substrate junction 7.04E03 GO:15078 hydrogen ion transmembrane transporter activity 7.04E03 GO:30216 keratinocyte differentiation 7.20E03 GO:1901606 alpha-amino acid catabolic process 7.30E03 GO:16324 apical plasma membrane 7.49E03 GO:70469 respiratory chain 7.58E03 GO:5976 polysaccharide metabolic process 7.58E03 GO:51707 response to other organism 7.59E03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process 7.60E03 GO:60351 cartilage development involved in endochondral bone morphogenesis 7.72E03 GO:44275 cellular carbohydrate catabolic process 7.72E03 GO:48041 focal adhesion assembly 7.72E03 GO:30212 hyaluronan metabolic process 7.72E03 GO:7017 microtubule-based process 7.94E03 GO:30145 manganese ion binding 7.94E03 GO:5882 intermediate filament 7.99E03 GO:31667 response fo nutrient levels 7.99E03 GO:9113 purine nucleobase biosynthetic process 7.99E03 GO:19511 peptidyl-proline hydroxylation 7.99E03 GO:90075 relaxation of muscle 7.99E03 GO:51156 glucose 6-phosphate metabolic process 7.99E03 GO:2000811 negative regulation of anoikis 7.99E03 GO:5527 macrolide binding 7.99E03 GO:5528 FK506 binding 7.99E03 GO:51172 negative regulation of nitrogen compound metabolic process 8.06E03 GO:10817 regulation of hormone levels 8.19E03 GO:9123 nucleoside monophosphate metabolic process 8.31E03 GO:2764 immune response-regulating signaling pathway 8.52E03 GO:32436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 8.52E03 GO:43236 laminin binding 8.53E03 GO:4602 glutathione peroxidase activity 8.53E03 GO:5504 fatty acid binding 8.53E03 GO:55038 recycling endosome membrane 8.53E03 GO:790 nuclear chromatin 8.68E03 GO:6029 proteoglycan metabolic process 8.71E03 GO:60491 regulation of cell projection assembly 8.79E03 GO:50821 protein stabilization 8.79E03 GO:6626 protein targeting to mitochondrion 8.79E03 GO:8610 lipid biosynthetic process 8.90E03 GO:3743 translation initiation factor activity 8.94E03 GO:2429 immune response-activating cell surface receptor signaling pathway 9.02E03 GO:19674 NAD metabolic process 9.12E03 GO:50766 positive regulation of phagocytosis 9.12E03 GO:1901570 fatty acid derivative biosynthetic process 9.12E03 GO:5791 rough endoplasmic reticulum 9.12E03 GO:7266 Rho protein signal transduction 9.12E03 GO:46456 icosanoid biosynthetic process 9.12E03 GO:17016 Ras GTPase binding 9.16E03 GO:33157 regulation of intracellular protein transport 9.16E03 GO:46683 response to organophosphorus 9.29E03 GO:32101 regulation of response to external stimulus 9.38E03 GO:62 fatty-acyl-CoA binding 9.38E03 GO:43124 negative regulation of I-kappaB kinase/NF-kappaB cascade 9.38E03 GO:42287 MHC protein binding 9.38E03 GO:46961 proton-transporting ATPase activity, rotational mechanism 9.38E03 GO:35304 regulation of protein dephosphorylation 9.38E03 GO:791 euchromatin 9.38E03 GO:10591 regulation of lamellipodium assembly 9.38E03 GO:6067 ethanol metabolic process 9.38E03 GO:19829 cation-transporting ATPase activity 9.46E03 GO:18119 peptidyl-cysteine S-nitrosylation 9.52E03 GO:16418 S-acetyltransferase activity 9.52E03 GO:36125 fatty acid beta-oxidation multienzyme complex 9.52E03 GO:16507 mitochondrial fatty acid beta-oxidation multienzyme complex 9.52E03 GO:16509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity 9.52E03 GO:60143 positive regulation of syncytium formation by plasma membrane fusion 9.52E03 GO:51410 detoxification of nitrogen compound 9.52E03 GO:16744 transferase activity, transferring aldehyde or ketonic groups 9.52E03 GO:17070 U6 snRNA binding 9.52E03 GO:1765 membrane raft assembly 9.52E03 GO:17014 protein nitrosylation 9.52E03 GO:1849 complement component C1q binding 9.52E03 GO:70836 caveola assembly 9.52E03 GO:1901163 regulation of trophoblast cell migration 9.52E03 GO:71682 endocytic vesicle lumen 9.52E03 GO:34112 positive regulation of homotypic cell-cell adhesion 9.52E03 GO:4301 epoxide hydrolase activity 9.52E03 GO:4822 isoleucine-tRNA ligase activity 9.52E03 GO:90501 RNA phosphodiester bond hydrolysis 9.52E03 GO:6428 isoleucyl-tRNA aminoacylation 9.52E03 GO:32437 cuticular plate 9.52E03 GO:14809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 9.52E03 GO:38069 positive regulation of cell migration by vascular endothelial growth factor signaling pathway 9.52E03 GO:46790 virion binding 9.52E03 GO:31340 positive regulation of vesicle fusion 9.52E03 GO:46292 formaldehyde metabolic process 9.52E03 GO:30911 TPR domain binding 9.52E03 GO:72330 monocarboxylic acid biosynthetic process 9.53E03 GO:1901800 positive regulation of proteasomal protein catabolic process 9.60E03 GO:2020 protease binding 9.61E03 GO:72655 establishment of protein localization to mitochondrion 9.61E03 GO:32479 regulation of type I interferon production 9.61E03 GO:6259 DNA metabolic process 9.73E03 GO:71453 cellular response to oxygen levels 9.78E03 GO:71559 response to transforming growth factor beta stimulus 9.79E03 GO:6694 steroid biosynthetic process 9.85E03 GO:31965 nuclear membrane 9.91E03
(98) TABLE-US-00003 TABLE 3 Lists of ECM and organogenesis/morphogenesis proteins identified in both engineered and native VF mucosae. Identifications were based on a 1% false discovery rate. Corresponding heatmaps are presented in FIG. 3F. Proteins are listed in order of descending fold change (native VF mucosa compared to engineered VF mucosa). Gene Fold symbol Protein name change ECM proteins ALB Serum albumin 28.43 TNXB Tenascin-X 17.07 COL5A1 Collagen: alpha-1(V) chain 14.10 DPYSL3 Dihydropyrimidinase-related protein 3 9.79 FBLN1 Fibulin-1 7.39 FBN1 Fibrillin-1 6.16 SERPINB1 Leukocyte elastase inhibitor 5.57 CLU Clusterin 4.82 BGN Biglycan 4.77 HSPG2 Basement membrane-specific heparan 3.25 sulfate proteoglycan care protein TGFBI Transforming growth factor-beta- 3.25 induced protein ig-h3 CD109 CD109 antigen 3.22 B2M Beta-2-microglobulin 3.07 HMGB1 High mobility group protein B1 2.53 COL18A1 Collagen alpha-1(XVIII) chain 2.35 LUM Lumican 2.27 COL6A2 Collagen alpha-2(VI) chain 2.12 DCN Decorin 1.88 COL6A1 Collagen alpha-1(VI) chain 1.65 LGALS3 Galectin-3 1.63 MYH9 Myosin-9 1.62 STOM Erythrocyte band 7 integral membrane protein 1.60 ANXA1 Annexin A1 1.59 PCYOX1 Prenylcysteine oxidase 1 1.51 ACTN4 Alpha-actinin-4 1.50 HSPD1 60 kDa heat shock protein, mitochondrial 1.49 CTSD Cathepsin D 1.47 CLTC Clathrin heavy chain 1 1.36 COL6A3 Collagen alpha-3(VI) chain 1.35 GSN Gelsolin 1.26 GPI Glucose-6-phosphate isomerase 1.21 SOD1 Superoxide dismutase [Cu-Zn] 1.15 ALDOA Fructose-bisphosphate aldolase A 1.11 ANXA5 Annexin A5 1.10 LAMA5 Laminin subunit alpha-5 1.08 ANXA2 Annexin A2 1.00 ENO1 Alpha-enclase 0.99 FBLN2 Fibulin-2 0.99 TUBB Tubulin beta chain 0.97 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0.96 HSPA8 Heat shock cognate 71 kDa protein 0.95 CALR Calreticulin 0.95 CTSB Cathepsin B 0.91 ACTN1 Alpha-actinin-1 0.91 VIM Vimentin 0.82 COL3A1 Collagen alpha-1(III) chain 0.81 MSN Mossin 0.81 PRDX4 Peroxiredoxin-4 0.71 MVP Major vault protein 0.71 PKM Pyruvate kinase isozymes M1/M2 0.70 ANXA6 Annexin A6 0.69 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0.65 AKR1B1 Aldose reductase 0.64 AHSG Alpha-2-HS-glycoprotein 0.63 COPA Coatomer subunit alpha 0.61 FN1 Fibronectin 0.55 FLNA Filamin-A 0.51 RNH1 Ribonuclease inhibitor 0.50 RBMX RNA-bad motif protein, X chromosome 0.50 ITGB1 Integrin beta-1 0.50 MYOF Myoferlin 0.47 LGALS3BP Galectin-3-binding protein 0.45 LGALS1 Gatectin-1 0.44 MYO1C Unconventional myosin-lc 0.41 THBS1 Thrombospondin-1 0.35 LAMC1 Laminin subunit gamma-1 0.34 HDGF Hepatoma-derived growth factor 0.31 EMILIN1 EMILIN-1 0.31 SERPINF1 Pigment epithelium-derived factor 0.26 TLN1 Talin-1 0.25 NT5E 5'-nucleotidase 0.20 COL12A1 Collagen alpha-1(XII) chain 0.19 PSAP Proactivator polypeptide 0.19 HDLBP Vigilin 0.16 COL1A2 Collagen alpha-2(I) chain 0.09 COL1A1 Collagen alpha-1(I) chain 0.07 Organogenesis/morphogenesis proteins JUP Junction plakoglobin 84.57 KRT5 Keratin, type II cytoskeletal 5 32.13 PPL Periplakin 23.40 KRT14 Keratin, type I cytoskeletal 14 22.50 KRT6B Keratin, type II cytoskeletal 6B 16.64 COL5A1 Collagen alpha-1(V) chain 10.13 STEAP4 Metalioreductase STEAP4 8.06 DPYSL3 Dihydropyrimidinase-elated protein 3 6.97 FBLN1 Fibulin-1 5.27 OGDH 2-oxoglutarate dehydrogenase, mitochondrial 5.26 FBN1 Fibrillin-1 4.36 DLD Dihydrolipoyl dehydrogenase, mitochondrial 3.47 ATP2A2 Sarcoplasmic/endoplasmic reticulum 3.45 calcium ATPase 2 SOD2 Superoxide dismutase [Mn], mitochondrial 2.95 PRDX3 Thioredoxin-dependant peroxide 2.48 reductase, mitochondrial ASAH1 Acid ceramidase 2.44 RAB11A Ras-related protein Rab-11A 2.41 HSPGA Basement membrane-specific heparan 2.31 sulfate proteoglycan core protein ADD1 Alpha-adducin 2.29 TGFBI Transforming growth factor-beta- 2.29 induced protein ig-h3 B2M Beta-2-microglobulin 2.19 KRT10 Keratin, type I cytoskeletal 10 1.85 HMGB1 High mobility group protein B1 1.79 COL18A1 Collagen alpha-1(XVIII) chain 1.65 NPM1 Nucleophosmin 1.65 LUM Lumican 1.61 AP2A2 AP-2 complex subunit alpha-2 1.60 PHB2 Prohibition-2 1.53 COL6A2 Collagen alpha-2(VI) chain 1.49 FERMT2 Fermitin family homolog 2 1.48 ATP5A1 ATP synthase subunit alpha, mitochondrial 1.34 DCN Decorin 1.33 XRCC5 X-ray repair cross-complementing protein 5 1.29 SPTAN1 Spectrin alpha chain, non-erthrocyclic 1 1.26 SPTBN1 Spectrin beta chain, non-erthrocyclic 1 1.25 COL6A1 Collagen alpha-1(V1) chain 1.16 TPP1 Tripeptidyl-peptidase 1 1.16 LGALS3 Galetin-3 1.15 MYH9 Myosin-9 1.15 RPS14 40S ribosomal protein S14 1.14 ANXA1 Annexin A1 1.12 SRI Sorcin 1.10 NDRG1 Protein NDRG1 1.10 ATP5B ATP synthase subunit beta, mitochondrial 1.08 HSPD1 60 kDa shock protein, mitochondrial 1.06 CANX Calnexin 1.02 RPS4X 40S ribosomal protein S4, X isoform 1.00 APEX1 DNA-(apurinic or apyrimidinic site) lyase 0.99 COL6A3 Collagen alpha-3(VI) chain 0.95 RPN2 Dolichyl-diphosphooligosaccharide-protein 0.92 glycosyltransferase subunit 2 CDC42 Cell division control protein 42 homolog 0.91 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0.90 DYNLL1 Dynein light chain 1, cytoplasmic 0.90 GSN Gelsolin 0.89 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0.88 GPI Glucose-6-phosphate isomerase 0.86 RPL22 60S ribosomal protein L22 0.83 SOD1 Superoxide dismutase [Cu-Zn] 0.82 PRDX1 Peroxiredoxin-1 0.80 TAGLN2 Transgelin-2 0.78 LAMA5 Laminin subunit alpha-5 0.76 ANXA2 Annexin A2 0.70 RTCB tRNA-splicing ligase RtcB homolog 0.70 GSTP1 Glutathione S-transferase P 0.70 YWHAG 14-3-3 protein gamma 0.69 MYL6 Myosin light polypeptide 6 0.69 RAB14 Ras-related protein Rab-14 0.68 CALR Calreticulin 0.67 LMNA Prelamin-A/C 0.64 NAPA Alpha-soluble NSF attachment protein 0.64 NCL Nucleolin 0.64 ARF4 ADP-ribosylation factor 4 0.64 TPI1 Triosephosphate isomerase 0.63 KRT1 Keratin, type II cytoskeletal 1 0.62 ALDOC Fructose-bisphosphate aldotase C 0.61 CFL1 Cofilin-1 0.61 S100A4 Protein S100-A4 0.59 AP2B1 AP-2 complex subunit beta 0.58 VIM Vimentin 0.58 COL3A1 Collagen alpha-1(III) chain 0.57 YWHAB 14-3-3 protein beta/alpha 0.57 TGM2 Protein-glutamine gamma-glutamyltransferase 2 0.57 HSP90AA1 Heat shock protein HSP 90-alpha 0.56 KRT9 Keratin, type I cytoskeletal 9 0.56 TMED10 Transmembrane emp24 domain-containing protein 10 0.56 FLOT1 Flotillin-1 0.56 RPL10A 60S ribosomal protein L10a 0.56 GNB2L1 Guanine nucleotide-binding protein 0.56 subunit beta-2-like 1 HSPA5 78 kDa glucose-regulated protein 0.55 RPS3A 40S ribosomal protein S3a 0.54 RPS19 40S ribosomal protein S19 0.53 RHOC Rho-related GTP-binding protein RhoC 0.52 DPYSL2 Dihydropyrimidinase-related protein 2 0.51 SF3B1 Splicing factor 3B subunit 1 0.50 CD44 CD44 antigen 0.49 41889 Septin-7 0.49 CAPN2 Calpain-2 catalytic subunit 0.48 CAV1 Caveolin-1 0.47 RTN4 Reticulon-4 0.46 AHSG Alpha-2-HS-glycoprotein 0.44 ACTR3 Actin-related protein 3 0.44 AHNAK Neuroblast differentiation-associated 0.42 protein AHNAK HSP90AB1 Heat shock protein HSP 90-beta 0.42 CAP1 Adenylyt cyclase-associated protein 1 0.40 XRCC6 X-ray repair cross-complementing protein 6 0.40 AP2M1 AP-2 complex subunit mu 0.40 FN1 Fibronectin 0.39 MGST1 Microsomal glutathione S-transferase 1 0.38 VCL Vinculin 0.38 PFN1 Profilin-1 0.38 FLNA Filamin-A 0.36 NACA Nascent polypeptide-associated 0.35 complex subunit alpha ITGB1 Integrin beta-1 0.35 FLNC Filamin-C 0.35 DBI Acyl-CoA-binding protein 0.35 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0.34 LGALS1 Galectin-1 0.31 NMNT Nicotinamide N-methyltransferase 0.30 ASPH Aspartyl/asparaginyl beta-hydroxylase 0.30 VAPA Vesicle-associated membrane 0.29 protein-associated protein A 41884 Septin-2 0.28 ARHGDIA Rhe GDP-dissociation inhibitor 1 0.26 BSG Basigin 0.26 THBS1 Thrombospondin-1 0.25 LAMC1 Laminin subunit gamma-1 0.24 PRKDC DNA-dependent protein kinase catalytic subunit 0.22 S100A6 Protein S100-A6 0.20 SERPINF1 Pigment epithelium-derived factor 0.19 DDX1 ATP-dependent RNA helicase DDX1 0.18 TLN1 Talin-1 0.18 PRKCSH Glucosidase 2 subunit beta 0.18 NDUFV2 NADH dehydrogenase [ubiquinone] 0.18 flavoprotein 2, mitochondrial STAT1 Signal transducer and activator of 0.17 transcription 1-alpha/beta RCN1 Reticulocalbin-1 0.17 ADH5 Alcohol dehydrogenase class-3 0.16 ARF6 ADP-ribosylation factor 6 0.15 COL12A1 Collagen alpha-1(XII) chain 0.14 PSAP Proactivator polypeptide 0.13 LRP1 Prolow-density lipoprotein 0.12 receptor-related protein 1 CAT Catalase 0.12 ANPEP Aminopeptidase N 0.07 COL1A2 Collagen alpha-2(I) chain 0.07 UGDH UDP-glucose 6-dehydrogenase 0.06 COL1A1 Collagen alpha-1(I) chain 0.05 HEXB Beta-hexosaminidase subunit beta 0.03
(99) TABLE-US-00004 TABLE 4 Lists of proteins significantly overrepresented in engineered VF mucosa compared to VFE on scaffold, VFE on scaffold compared to engineered VF mucosa, engineered VF mucosa compared to VFF in scaffold, and VFF in scaffold compared to engineered VF mucosa. The cutoff criteria for quantitative protein overrepresentation were fold change > 4 and Benjamini Hochberg-adjusted P < 0.01. Corresponding Volcano plots and heatmaps are presented in FIG. 7. Proteins are listed in order of descending fold change. Uniprot accession Gene Fold Adjusted number Protein name symbol change P-value Overrepresented in engineered VF mucosa compared to VFE on scaffold Q92928 Putative Ras-related protein Rab-1C RAB1C 136.29 1.79E05 P05141 ADP/ATP transfocase 2 SLC25A5 127.20 2.44E05 P10909 Clusterin CLU 90.45 1.06E04 P08134 Rho-related GTP-binding protein RhoC RHOC 86.81 1.11E04 Q92688 Acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B 72.09 6.66E05 Q9UB16 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 GNG12 56.71 6.69E05 P46776 60S ribosomal protein L27a RPL27A 55.58 3.36E04 P84103 Serine/arginine-rich splicing factor 3 SRSF3 50.11 5.32E04 P62280 40S ribosomal protein S11 RPS11 48.83 7.13E05 P10619 Lysosomal protective protein CTSA 47.59 2.94E04 P13987 CD59 glycoprotein CD59 44.45 3.95E01 O94973 AP-2 complex subunit alpha-2 AP2A2 43.47 3.37E03 P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP5 43.18 5.22E04 P62266 40S ribosomal protein S23 RPS23 37.52 1.90E04 O43143 Putative pre-mRNA-splicing factor ATP- DHX15 35.96 1.11E04 dependent RNA helicase DHX15 O75533 Splicing factor 3B subunit 1 SF3B1 30.75 9.95E03 Q9UKK3 Poly [ADP-ribose] polymerase 4 PARP4 27.01 9.73E05 P61254 60S ribosomal protein L26 RPL26 26.69 3.15E04 P01026 Complement C3 [Cleaved into: Complement C3 beta chain; C3 24.97 6.50E04 Complement C3 alpha chain] P30046 D-dopachrome decarboxylase DDT 24.82 3.71E04 P30740 Leukocyte elastase inhibitor SERPINB1 23.87 4.39E03 Q6IBS0 Twinfilin-2 TWF2 23.87 4.46E03 O75351 Vacuolar protein sorting-associated protein 4B VPS4B 22.45 2.97E04 Q9UEY8 Gamma-adducin ADD3 19.93 1.08E03 P20073 Annexin A7 ANXA7 19.78 6.89E04 Q9NYL9 Tropomodulin-3 TMOD3 17.74 1.91E04 O94855 Protein transport protein Sec24D SEC24D 15.70 8.45E04 P36405 ADP-ribosylation factor-like protein 3 ARL3 15.70 8.65E04 P55036 26S proteasome non-ATPase regulatory subunit 4 PSMD4 43.48 9.95E03 P08648 Integrin alpha-5 ITGA5 11.31 8.87E03 Q9P0L0 Vesicle-associated membrane protein-assoctated protein A VAPA 10.99 2.97E03 P21291 Cysteine and glycine-rich protein 1 CSRP1 8.79 5.01E03 P62491 Ras-related protein Rab-11A RAB11A 6.75 3.33E04 Overrepresented in VFE on scaffold compared to engineered mucosa P05539 Collagen alpha-1(II) chain COL2A1 416.83 1.06E04 P62820 Ras-related protein rab-1A RAB1A 127.00 4.58E05 P06962 CD63 antigen CD63 51.40 3.73E04 P02770 Serum albumin ALB 49.99 1.62E05 P43235 Cathepsin K CTSK 49.08 1.27E03 P35754 Glutaredoxin-1 GLRX 44.94 1.02E04 P13693 Translationally-controlled tumor protein TPT1 44.56 1.85E04 P01889 HLA class I histocompatibility antigen, B-7 alpha chain HLA-B 42.11 1.15E05 P20340 Ras-related protein Rab-6A RAB6A 37.88 9.66E05 P62753 40S ribosomal protein S6 RPS6 35.28 5.16E03 P02795 Metaliothionein-2 MT2A 31.19 9.90E03 P37235 Hippocalcin-like protein 1 HPCAL1 30.97 1.65E05 P23141 Liver carboxylesterase 1 CES1 28.75 2.32E05 P63173 60S ribosomal protein L38 RPL38 28.37 1.99E04 P48681 Nestin NES 27.71 7.33E04 Q92945 Far upstream element-binding protein 2 KHSRP 27.27 3.28E03 P62899 60S ribosomal protein L31 RPL31 25.86 4.10E03 P62847 40S ribosomal protein S24 RPS24 25.55 6.95E03 P61163 Alpha-centractin ACTR1A 24.13 1.53E03 O95292 Vesicle-associated membrane protein-associated protein B/C VAPB 23.47 1.76E04 P02640 Apolipoprotein E APOE 23.25 5.35E04 Q9Y5X1 Sorting nexin-9 SNX9 21.84 1.35E03 P14406 Cytochrome c oxidase subunit 7A2, mitachondrial CO7A2 21.84 1.33E03 Q9Y646 Carboxypeptidase Q CPQ 20.21 9.72E03 P22307 Non-specific lipid-transfer protein SCP2 19.24 1.92E05 P28799 Granulins GRN 19.02 1.26E03 Q1KMD3 Heterogeneous nuclear ribonucleoprotein U-like protein 2 HNRNPUL2 17.23 1.26E03 P27706 CAD protein [Includes: Glutamin-dependent carbamoyl-phosphate synthase CAD 15.75 6.95E03 P62913 60S ribosomal protein L11 RPL11 13.37 9.90E05 Q16718 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 13.37 1.07E04 P67812 Signal peptidase complex catalytic subunit SEC11A SEC11A 11.75 3.26E04 P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 11.74 3.07E04 Q15063 Periostin POSTN 11.74 3.16E04 Q9BTV4 Transmembrane protein 43 TMEM43 11.14 7.27E03 O60740 Sorting nexin-2 SNX2 9.51 3.33E03 O00754 Lysosomal alpha-mannosidase MAN2B1 5.87 8.48E04 Overpresented in engineered VFF mucosa compared to VFF in scaffold P42330 Aldo-keto reductase family 1 member C3 AKR1C3 228.80 9.75E05 P35556 Fibrillin-2 FBN2 213.61 2.29E04 P98095 Fibulin-2 FBLN2 176.02 6.98E05 P39687 Acidic leucine-rich nuclear phosphoprotein 32 family member A ANP32A 94.87 1.37E04 P27105 Erythrocyte band7 integral membrane protein STOM 93.36 1.59E04 Q9Y6C2 EMILIN-1 EMILIN1 92.41 2.15E04 P61586 Transforming protein RhoA RHOA 89.42 1.18E04 P06753 Tropomyosin alpha-3 chain TPM3 84.67 1.10E04 P13674 Prolyl 4-hydroxytase subunit alpha-1 P4HA1 82.35 9.22E05 P42785 Lysosomal Pro-X carboxypeptidase PRCP 72.67 8.12E05 P00325 Alcohol dehydrogenase 1B ADH1B 69.66 5.62E03 P20700 Lamin-B1 LMNB1 61.16 1.60E04 P60866 40S ribosomal protein S20 RPS20 58.85 8.84E05 P62750 60S ribosomal protein L23a RPL23A 58.69 1.21E04 P51688 N-sulphoglucosamine sulphohydrolase SGSH 57.39 3.73E04 P46926 Glucosamine-6-phosphate isomerase 1 GNPDA1 56.55 9.99E05 P01893 Putative HLA class I histocompatibility antigen, alpha chain H HLA-H 55.40 2.01E04 P00966 Argininosuccinate synthase ASS1 53.74 2.19E04 P55795 Heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 53.42 1.10E04 Q8NHP8 Putative phospholipase B-like 2 PLBD2 52.95 7.91E04 P27635 60S ribosomal protein L10 RPL10 52.12 1.50E04 P24752 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 47.33 3.09E03 P23142 Fibulin-1 FBLN1 47.16 7.94E03 P13987 CD59 glycoprotein CD59 46.53 2.86E04 Q16363 Laminin subunit alpha-4 LAMA4 46.51 1.41E04 Q9BS26 Endoplasmic reticulum resident protein 44 ERP44 46.01 4.15E04 O14773 Tripeptidyl-peptidase 1 TPP1 45.53 1.23E03 O94973 AP-2 complex subunit alpha-2 AP2A2 45.52 1.82E03 P45974 Ubiquitin carboxyl-terminal hydrolase 5 USP5 45.21 3.60E04 Q9Y3I0 tRNA-splicing ligase RtcB homolog C22orf28 44.55 1.26E04 P42224 Signal transducer and activator of transcription 1-alpha/beta STAT1 43.88 3.65E04 P25789 Proteasome subunit alpha type-4 PSMA4 42.59 7.01E04 P30084 Enoyl-CoA hydratase, mitochondrial ECHS1 42.57 2.27E04 P19623 Spermidine synthase SRM 40.58 5.78E03 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 TRIM25 40.28 1.94E04 P20618 Proteasome subunit beta type-1 PSMB1 39.78 2.17E04 P62266 40S ribosomal protein S23 RPS23 39.28 1.63E04 Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase GRHPR 39.12 3.17E04 P36543 V-type proton ATPase subunit E 1 ATP6V1E1 37.82 3.71E04 Q9Y3U8 60S ribosomal protein L36 RPL36 37.80 5.88E04 P40261 Nicotinamide N-methyltransferase NNMT 37.66 1.69E03 Q43143 Putative pre-mRNA-splicing factor-ATP- DHX15 37.64 1.16E04 dependent RNA helicase DHX15 Q6NUM9 All-trans-retinol 13,14-reductase RETSAT 36.81 8.06E04 P13473 Lysosome-associated membrane glycoprotein 2 LAMP2 35.68 4.10E04 P07711 Cathepsin L1 CTSL1 35.18 2.14E04 P19404 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 33.55 7.09E04 Q9NR45 Sialic acid synthase NANS 33.38 1.35E03 Q15075 Early endosome antigen I EEA1 32.53 1.15E03 Q92597 Protein NDRG1 NDRG1 32.39 1.16E03 Q08360 Galectin-3-binding protein LGALS3BP 32.37 4.41E04 O75533 Splicing factor 3B subunit 1 SF3B1 32.20 5.45E03 P46439 Glutathione S-transferase Mu 5 GSTM5 32.20 5.40E03 P04062 Glucosylceramidase GBA 31.91 8.42E03 Q12906 Interleukin enhancer-binding factor 3 ILF3 31.59 7.21E03 Q8IZP2 Putative protein FAM10A4 ST13P4 30.91 2.97E04 P04179 Superoxide dismutase, [Mn] mitochondrial SOD2 30.89 6.68E03 Q5T9L3 Protein wntless homolog WLS 30.57 1.51E04 P07954 Fumanate hydratase, mitochondrial FH 30.57 1.57E04 P27487 Dipeptidyl peptidase 4 DPP4 30.41 8.97E05 Q9UIJ7 GTP:AMP phosphotransferase AK3, mitochondrial AK3 30.41 8.37E05 O14880 Microsomal glutathione S-transferase 3 MGST3 29.42 3.18E03 P35555 Fibrillin-1 FBN1 28.46 7.93E03 P10768 S-formylglutathione hydrolase ESD 28.44 7.00E04 Q9UKK3 Poly [ADP-ribose] polymerase 4 PARP4 28.28 1.01E04 O95741 Serine/threonine-protein kinase OSR1 OXSR1 28.28 9.63E05 P61254 60S ribosomal protein L26 RPL26 27.94 2.27E04 O43491 Band 4.1-like protein 2 EPB41L2 27.78 1.51E04 O15145 Actin-related protein 2/3 complex subunit 3 ARPC3 27.78 1.56E04 O43615 Mitochondrial import inner membrane translocase subunit TIM44 TIMM44 26.48 1.47E03 Q9Y371 Endophilin-B1 SH3GLB1 25.64 6.99E05 Q32P28 Prolyl 3-hydroxylase 1 LEPRE1 25.64 7.38E05 P22087 rRNA 2-O-methyltransferase fibrillarin FBL 25.64 7.81E05 P07942 Laminin subunit beta-1 LAMB1 25.30 1.46E03 P00403 Cytochrome c oxidase subunit 2 MT-CO2 24.98 2.46E03 P30740 Leukocyte elastase inhibitor SERPINB1 24.98 2.48E03 P28161 Glutathione S-transferase Mu 2 GSTM2 24.34 5.12E03 P49589 Cysteine--tRNA ligase, cytoplasmic CARS 23.84 5.53E04 Q16643 Drebrin DBN1 23.50 2.19E04 Q13263 Transcription intermediary factor 1-beta TRIM28 23.50 2.24E04 O75351 Vacuolar protein sorting-associated protein 4B VPS4B 23.50 2.34E04 P14868 Asparate--tRNA ligase, cytoplasmic DARS 23.50 2.29E04 Q02543 60S ribosomal protein L18 RPL18A 23.34 1.18E04 P38606 V-type proton ATPase catalytic subunit A ATP6V1A 23.01 7.46E04 O00151 PDZ and LIM domain protein 1 PDLIM1 22.85 1.23E03 P06756 Integrin alpha-V ITGAV 22.85 1.25E03 Q13228 Selenium-binding protest 1 SELENBP1 22.04 7.51E03 Q13561 Dynactin subunit 2 DCTN2 21.70 2.75E03 P43490 Nicotinamide phosphoribosyltransferase NAMPT 21.54 2.15E03 P62714 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 21.21 1.21E03 O95336 6-phosphogluconolactonase PGLS 21.05 1.16E03 Q14112 Nidogen-2 NID2 20.87 7.16E04 Q9Y4L1 Hypoxia up-regulated protein 1 HYOU1 19.41 4.46E03 P80303 Nucleobindin-2 NUCB2 18.91 6.94E04 P0CW22 40S ribosomal protein S77-like RPSI7L 18.57 1.82E04 Q02818 Nucleobindin-1 NUCB1 18.07 8.85E03 P02461 Collagen alpha-1(III) chain COL3A1 17.57 4.94E03 P53007 Tricarboxylate transport protein, mitochondrial SLC25A1 16.77 1.45E03 P05091 Aldehyde dehydrogenase, mitochondrial ALDH2 16.44 5.95E04 Q9HC38 Glyoxalase domain-containing protein 4 GLOD4 16.44 5.86E04 P36405 ADP-ribosylation factor-like protein 3 ARL3 15.44 6.04E04 P99999 Cytochrome c CYCS 16.28 2.54E04 P46063 ATP-dependent DNA helicase Q1 RECQL 16.28 2.59E04 P42765 3-ketoacyl-CoA thiolase, mitochondrial ACAA2 16.28 2.64E04 P54727 UV excision repair protein RAD23 homolog B RAD23B 15.94 6.16E03 O75955 Flotillin-1 FLOT1 15.78 8.61E03 Q16891 Mitochondrial inner membrane protein IMMT 14.14 1.53E04 Q9P2J5 Leucine--tRNA ligase, cytoplasmic LARS 14.14 1.58E04 P10515 Dihydrolipoyllysine-residue acetyltransferase component of DLAT 13.80 5.37E03 pyruvate dehydrogenase complex, mitochondrial P55735 Protein SEC13 homolog SEC13 13.80 5.41E03 Q02218 2-oxoglutarate dehydrogenase, mitochondrial OGDH 13.80 5.45E03 P55036 26S proteasome non-ATPase regulatory subunit 4 PSMD4 13.80 5.50E03 P54578 Ubiquitin carboxyl-terminal hydrolase 14 USP14 11.84 4.97E03 Q12884 Seprase FAP 11.84 4.93E03 Q9P0L0 Vesicle-associated membrane protein-associated protein A VAPA 11.50 1.66E03 O15230 Laminin subunit alpha-5 LAMA5 9.70 9.44E03 Q6IAA8 Ragulator complex protein LAMTOR1 LAMTOR1 9.70 9.51E03 Q96FQ6 Protein S100-A16 S100A16 9.70 9.57E03 P27701 CD82 antigen CD82 9.70 9.63E03 P63220 40S ribosomal protein S21 RPS21 9.37 5.15E03 Q6P2Q9 Pre-MRNA-processing-splicing factor 8 PRPF8 9.21 2.93E03 Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD PYCARD 9.21 2.90E03 P62491 Ras-related protein Rab-11A RAB11A 7.07 3.20E04 Overrepresented in VFF in scaffold compared to engineered VF mucosa P05530 Collagen alpha-1(II) chain COL2A1 333.66 1.19E04 P02770 Serum albumin ALB 68.56 2.08E04 P60903 Protein S100-A10 S100A10 49.96 4.11E04 P01024 Complement C3 C3 45.51 3.10E03 P02774 Vitamin D-binding protein GC 42.27 2.93E06 P62857 40S ribosomal protein S28 RPS28 41.71 8.10E04 P02788 Lactotransferrin LTF 40.99 6.76E04 P13693 Translationally-controlled tumor protein TPT1 39.35 3.21E04 P01008 Antithrombin-III SERPINC1 22.39 5.52E03 P30493 HLA class I histocompatibility antigen, B-55 alpha chain HLA-B 21.48 1.76E03 P62753 40S ribosomal protein S6 RPS6 21.05 9.25E04 P62917 60S ribosomal protein L8 RPL8 13.95 6.92E03 P35637 RNA-binding protein FUS FUS 13.65 3.67E03 P49458 Signal recognition particle 9 kDa protein SRP9 13.06 7.08E03 O15143 Actin-related protein 2/3 complex subunit 1B ARPC1B 7.40 5.74E03 P67809 Nuclease-sensitive element-binding protein 1 YBX1 7.40 5.79E03 Q9BR76 Coronin-1B CORO1B 7.40 5.83E03
(100) TABLE-US-00005 TABLE 5 Gene ontology biological process terms enriched in the protein set exclusive to engineered VF mucosa or overrepresented in engineered mucosa compared to both VFF in scaffold and VFE on scaffold. The cutoff criteria for quantitative protein enrichment overrepresentation were fold change > 4 and Benjamini Hochberg-adjusted P < 0.01. Enriched ontology terms were identified using the BiNGO enrichment and REViGO term redundancy algorithms. A subset of these biological process terms are presented in FIG. 6D. Terms are listed in order of ascending Benjamini Hochberg-adjusted P-value. Biological process Adjusted term Description P-value GO:0044265 cellular macromolecule catabolic process 1.36E05 GO:0008104 protein localization 2.30E05 GO:0071840 cellular component organization or biogenesis 3.97F05 GO:0016071 mRNA metabolic process 1.29E04 GO:0034641 cellular nitrogen compound metabolic process 2.53E04 GO:0006807 nitrogen compound metabolic process 4.12E04 GO:0022411 cellular component disassembly 7.32E04 GO:0086004 regulation of cardiac muscle cell contraction 8.91E04 GO:0006413 translational initiation 1.41E03 GO:0044281 small molecule metabolic process 1.47E03 GO:1901360 organic cyclic compound metabolic process 1.56E03 GO:0007044 cell-substrate junction assembly 3.03E03 GO:0044710 single-organism metabolic process 3.31E03 GO:0046483 heterocycle metabolic process 5.18E03 GO:0008544 epidermis development 5.27E03 GO:0006725 cellular aromatic compound metabolic process 5.27E03 GO:0034332 adheres junction organization 7.35E03 GO:0071704 organic substance metabolic process 7.55E03 GO:0006577 amino-acid betainemetabolic process 8.58E03 GO:0034329 cell juncton assembly 8.72F03 GO:0044349 DNA excision 9.22E03 GO:0030162 regulation of proteolysis 9.35E03
(101) TABLE-US-00006 TABLE 6 Antibodies and isotype controls used for flow cytometry. Fluoro- Catalog Item Clone chrome Dilution Manufacturer number Antibodies rabbt anti-human P4H- polyclonal FITC 1:50 Bioss bs-5090R mouse anti-human CD90 5E10 PE-Cy7 1:20 BD Biosciences 561556 mouse anti-human keratin LL002 FITC 1:10 Abcam ab77684 mouse anti-human pan-keratin C11 Alexa 647 1:50 Cell Signaling 4528 Technology mouse anti-human CD227 16A PE 1:20 BioLegend 355603 mouse anti-human keratin 19 RCK108 PerCP 1:5 Santa CRUZ sc-53003 Biotechnology mouse anti-human HLA-ABC W6/32 Alexa 488 1:20 BioLengend 311415 mouse anti-human HLA-DR LN3 PE 1:20 eBioscience 12-9956 mouse anti-human PD-L1 (CD274) 29E.2A3 APC 1:20 BioLegend 329706 mouse anti-human PD-L2 (CD273) MIH18 APC 1:20 BioLegend 345507 mouse anti-human CD80 L307.4 FITC 1:20 BD Biosciences 557226 mouse anti-human CD86 IT2.2 PE 1:20 BioLegend 305406 mouse anti-human pan-CD45 HI30 APC 1:20 BD Biosciences 555485 rat anti-mouse pan-CD45 30F11 FITC 1:20 BD Biosciences 553080 isotype controls rabbit IgG EPR25A none 1:100 Abcam ab172730 mouse IgG1 ICIGG1 none 1:200 Abcam ab91353 MOPC-21 APC 1:20 BD Biosciences 400121 MOPC-21 FITC 1:20 BD Biosciences 400107 MOPC-21 PE 1:20 BD Biosciences 400111 mouse IgG2b MPC-11 APC 1:20 BioLegend 400321 MPC-11 PE 1:20 BioLegend 400314 rat IgG2b A95-1 FITC 1:20 BD Biosciences 553988
(102) TABLE-US-00007 TABLE 7 Antibodies used for immunocytochemistry and immunohistochemistry. Catalog Positive Item Clone Dilution Manufacturer number control Primary antibodies rabbit anti-human e-cadherin polyclonal 1:100 Santa Cruz sc-7870 vocal fold Biotechnology mouse anti-human P4H- 3-2B12 1:250 Chemicon MAB2701 vocal fold goat anti-human -actin 2 polyclonal 1:100 Thermo Scientific PA5-18292 vocal fold mouse anti-human collagen, type IV COL-94 1:100 Sigma-Aldrich C1926 vocal fold rabbit anti-human laminin 5 polyclonal 1:200 Abcam ab14509 vocal fold mouse anti-human keratin 5 XM26 1:100 Santa Cruz se-58732 vocal fold Biotechnology mouse anti-human junction plakoglobin 4C12 1:200 Abcam ab119908 vocal fold mouse anti-human mitochondria 113-1 1:200 Milipore MAB1273 thymus rabbit anti-human forkhead box P3 polyclonal 1:300 Abcam ab10563 thymus rabbit anti-human CD8 SP16 1:100 Biocare Medical CRM311 thymus rabbit anti-human CD4 EPR6855 1:200 Abcam ab133616 thymus mouse anti-human CD45 2B11; 1:100 Innovex MAB321C thymus PD7/26 Secondary antibodies.sup.a Alexa 488-conjugated donkey anti-mouse IgG 1:200 Life Technolooies A-21202 Alexa 594-conjugated donkey anti-mouse IgG 1:200 Life Technologies A-21203 Alexa 488-conjugated donkey anti-rabbit IgG 1:200 Life Technologies A-21206 Alexa 594-conjugated donkey anti-rabbit IgG 1:200 Life Technologies A-21207 Alexa 594-conjugated donkey anti-goat IgG 1:200 Life Technologies A-11058 .sup.aSecondary antibodies used for fluorescent detection are listed here; HRP-based detection is described in the Example Materials and Methods.