Fused quartz container having low levels of surface defects

Abstract

A quartz glass container is shown and described herein. The quartz glass container exhibits a low concentration of surface defects on an inner surface of the container. In aspects hereof, the container may have a surface defect density of 50 or fewer surface defects per square centimeter within a 1 cm band centered 1 cm from the base of the container.

Claims

1. A quartz glass pharmaceutical container defining an interior volume and having an upper end, a base end, at least one wall defining an inner surface and an outer surface, wherein the inner surface of the container has a surface feature density of 50 or fewer surface features per square centimeter within a 1 cm band centered 1 cm from the base end of the pharmaceutical container, the surface features having a size of 1 to 200 μm.

2. The quartz glass container of claim 1, wherein the surface feature density is 10 or fewer surface features per square centimeter.

3. The quartz glass container of claim 1, wherein the surface feature density is 5 or fewer surface features per square centimeter.

4. The quartz glass container of claim 1, wherein the container has a surface feature density of 5 or fewer surface features of 50 micron or greater per square centimeter.

5. The quartz glass container of claim 1, wherein the container has a surface feature density 5 or fewer surface features of 10 micron or greater per square centimeter.

6. The quartz glass container of claim 1, wherein the quartz glass container is chosen from a vial, a tube, a vacuum sealed tube, a cartridge, a syringe, a syringe barrel, or an ampoule.

7. The quartz glass container of claim 1 comprising a pharmaceutical fluid disposed in the container.

8. A process for forming a plurality of quartz glass containers comprising: providing a quartz glass tube having a first open end and second open end opposite the first open end; forming one or more features of a container at the first open end; forming one or more features of a container at the second open end; separating the quartz glass tube at a point distal to each of the first and second open ends, the separating operation providing two containers and forming a bottom of each container, wherein the pharmaceutical packaging container defines an interior volume and having an upper end, a base end, at least one wall defining an inner surface and an outer surface, wherein the inner surface of the container has a surface feature density of 50 or fewer surface features per square centimeter within a 1 cm band centered 1 cm from the base end of the pharmaceutical container, the surface features having a size of 1 to 200 μm.

9. The process of claim 8 comprising purging the tube with a gas during the step of (i) forming one or more features of a container at the first open end, (ii) forming one or more features of a container at the second open end, or both (i) and (ii).

10. The process of claim 8, wherein the process is operated to process 50 to 3000 quartz glass tubes per hour.

11. A pharmaceutical packaging container made from the process of claim 8.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) The accompanying drawings illustrate various systems, apparatuses, devices and related methods, in which like reference characters refer to like parts throughout, and in which:

(2) FIG. 1 is a cross-sectional view of a glass container;

(3) FIG. 2 is a photograph of a microscopic image of a glass surface having surface features derived from the redeposit of volatile glass constituents;

(4) FIG. 3 is a photograph of a microscopic image of a glass surface in accordance with aspects of the present technology;

(5) FIG. 4 is a photograph of a quartz glass container of a Comparative Example;

(6) FIG. 5 is a close up of the section enclosed in the box in FIG. 4; and

(7) FIG. 6 is a comparison of (a) the quartz glass container formed under the Comparative Example with (b) a quartz glass container formed in accordance with a method of the present disclosure.

DETAILED DESCRIPTION

(8) Reference will now be made to exemplary embodiments, examples of which are illustrated in the accompanying drawings. It is to be understood that other embodiments may be utilized and structural and functional changes may be made. Moreover, features of the various embodiments may be combined or altered. As such, the following description is presented by way of illustration only and should not limit in any way the various alternatives and modifications that may be made to the illustrated embodiments. In this disclosure, numerous specific details provide a thorough understanding of the subject disclosure. It should be understood that aspects of this disclosure may be practiced with other embodiments not necessarily including all aspects described herein, etc.

(9) As used herein, the words “example” and “exemplary” means an instance, or illustration. The words “example” or “exemplary” do not indicate a key or preferred aspect or embodiment. The word “or” is intended to be inclusive rather than exclusive, unless context suggests otherwise. As an example, the phrase “A employs B or C,” includes any inclusive permutation (e.g., A employs B; A employs C; or A employs both B and C). As another matter, the articles “a” and “an” are generally intended to mean “one or more” unless context suggest otherwise.

(10) Provided is a fused quartz glass container having low levels of surface defects on an inner surface of the container. As used herein, the term “surface features,” “redeposit features,” “surface defect,” “redeposit defect,” and “redeposit features of volatile glass particles” may be used interchangeably and refer to a surface feature arising from the redeposit or adherence of particulate matter on the inner surface of the container. The surface defects may typically arise from the manufacture of the glass article. They can be derived from redeposit of a volatilized or evaporated glass constituent during the manufacture of a glass article. They can also be derived from the adherence of glass particles that are not volatilized or evaporated material, but rather are particles or pieces that are produced during cutting or forming operations on the container during manufacture. The surface features may include glass particles, redeposited glass particles, adhered glass particles, redeposited particles that are not in a glass phase, pits, depressions, and craters, non-glass particles or other features (e.g. texture, rings, etc.) that resulted from the redeposit of volatile glass constituents. Pits, craters, and depressions may be considered as regions or voids where material has been removed from and is missing from a region of the quartz glass, and may result from material being volatilized from the glass surface itself.

(11) The surface features or defects are those features having a size (as determined by the largest dimension (e.g., length or width) of the feature) of greater than 1 μm and less than 200 μm. In embodiments, the redeposited glass particles may have a size of from about 1 μm to 200 μm; from about 10 μm to about 200 μm; from about 20 μm to about 150 μm; even from about 50 to about 100 μm. In still other embodiments, the surface features have a size of from greater than 10 μm to about 50 μm, or from greater than 10 μm to about 100 μm. In one embodiment, the surface features of volatile glass constituents are those having a size of 1 μm to about 10 μm. Here as elsewhere in the specification and claims, numerical values may be combined to form new and non-specified ranges. Moreover, the surface features have a two-dimensional aspect ratio (ratio of length to width of the feature) of less than 50, less than 20, less then 10, less than 5, less than 2, and even about 1. The two-dimensional aspect ratio is evaluated because the three dimensional shape of the feature may not be completely ascertainable when evaluating them through a microscope.

(12) The surface features are distinguished from delamination flakes. Delamination refers to a phenomenon in which glass particles are released from the surface of the glass during or after usage of the vial such as by storage of a fluid within the container. Delamination may arise from normal usage (e.g., movement of the fluid during transport, shipping, handling, etc.) or through a series of leaching, corrosion, and/or weathering reactions, and may or may not be observable prior to release. Redeposited glass particles, on the other hand, are observable with sufficient magnification before any particular exposure or reactions are applied to the glass. In general, the delamination glass particles are silica-rich flakes of glass that originate from the interior surface of the package as a result of the leaching of modifier ions into a solution contained within the package. These flakes may generally be from about 1 nm to about 2 μm thick with a width greater than about 50 μm. These flakes are primarily composed of silica, and generally do not further degrade after being released from the surface of the glass. Delamination produces particulate flakes or lamellae that are irregularly shaped and typically have a maximum length greater than about 50 μm but often greater than about 200 μm. The thickness of the flakes is usually greater than about 100 nm and may be as large as about 1 μm. Thus, the minimum aspect ratio of the flakes is typically greater than about 50. The aspect ratio may be greater than about 100 and sometimes greater than about 1000. Moreover, the redeposited features of volatile glass constituents, if present, are observable through microscopic analysis as discussed further herein. Delamination flakes, however, are typically not evidenced via microscopic analysis until the container is exposed to a fluid resulting in delamination of the glass material.

(13) Although the terms may be used to denote compositions or articles of different materials (different silica concentrations), as used herein, the term “quartz” may be used interchangeably with “quartz glass” or “fused quartz,” referring to a composition, a part, a product, or an article formed from a mixture comprising natural or synthetic sand (silica). As used herein, the term “quartz” also includes and may be used interchangeably with quartz glass, fused quartz, fused silica, amorphous silica, and vitreous silica. Either or both natural or synthetic sand (silica) can be used in the composition of the invention, and the term is used to denote compositions comprising either naturally occurring crystalline silica such as sand/rock, synthetically derived silicon dioxide (silica), or a mixture of both. The term “sand” may be used interchangeably with silica, denoting either natural sand or synthetic sand, or a mixture of both.

(14) The fused quartz containers comprise high purity silica. The silica in the fused quartz container has a silica content of 99.9 wt. % or greater. In still other embodiments, the glass compositions and articles formed therefrom have a SiO.sub.2 content of 99.99 wt. % or greater, 99.999 wt. % or greater. In further embodiments, the glass composition can have a SiO.sub.2 content of about 99.9 wt. % to about 99.9999 wt. %, about 99.9 wt. % to about 99.9995 wt. %, about 99.9 wt. % to about 99.999 wt. %, even about 99.99 wt. % to about 99.995 wt. %. Here as elsewhere in the specification and claims, ranges can be combined to form new and non-specified ranges.

(15) An example of a fused quartz glass container is illustrated in FIG. 1. The glass container 100 comprises a glass body 102 defining an inner surface 104 and an outer surface 106 and generally defines an interior volume 108. The container is shaped to define one or more walls 110, an upper end 112, and a base 114. The upper end 112 may define an opening 116 through which liquids stored within the container may exit the container. The opening may be configured to be covered by a cap, plug, lid, etc., or it may contain a frangible covering that may be broken to expose the opening.

(16) The container may be shaped as desired for a particular purpose or intended application. While the container may be substantially circular in circumference (and define a single unitary wall 110 having no defined edges or corners), the circumference of the container may define any shape (e.g., square, rectangular, hexagonal, etc.) and may thus define a plurality of walls 110 with adjacent walls meeting at an edge or corner. While the glass container 100 is depicted in FIG. 1 as having a specific shape form (i.e., a vial), it should be understood that the glass container 100 may have other shape forms, including, but not limited to, cartridges, syringes, syringe barrels, ampoules, bottles, flasks, phials, tubes, vacuum sealed tubes, beakers, or the like.

(17) In accordance with the present technology, the containers have a low concentration of surface features (density of surface features of volatile glass constituents) on the inner surface of the container. In order to simplify the analysis and exaggerate differences, as used herein, the density of surface features refers to the number of surface features on the inner surface of the container wall specifically within an approximately 1 cm wide band located in the vicinity where such features are considered prominent. The band is 1 cm wide and follows the entire circumference, such that the area of the band is equal to A.sub.b=1 [cm]*π*d[cm], where d refers to the inner diameter of the band. The location of this band on an axisymetric or axially oriented part is such that the center line of the band is located 1 cm up from the base of the container. The present glass containers have a surface feature density of 50 or fewer redeposited surface features per square centimeter; 40 or fewer surface features per square centimeter; 30 or fewer surface features per square centimeter; 20 or fewer surface features per square centimeter; 10 or fewer surface features per square centimeter; even 5 or fewer surface features per square centimeter.

(18) In one embodiment, the container has a surface feature density of 50 or fewer surface features in the size range of 10-200 μm or greater per square centimeter; 40 or fewer surface features in the size range of 10-200 μm or greater per square centimeter; 30 or fewer surface features in the size range of 10-200 μm or greater per square centimeter; 20 or fewer surface features in the size range of 10-200 μm per square centimeter; 10 or fewer surface features in the size range of 10-200 μm or greater per square centimeter; even 5 or fewer surface features in the size range of 10-200 μm or greater per square centimeter. Here as elsewhere in the specification and claims, ranges can be combined to form new and non-specified ranges.

(19) In one embodiment, the container has a surface feature density of 50 or fewer surface features of 1-10 μm per square centimeter; 40 or fewer surface features of 1-10 μm or greater per square centimeter; 30 or fewer surface features of 1-10 μm or greater per square centimeter; 20 or fewer surface features of 1-10 μm or greater per square centimeter; 10 or fewer surface features of 1-10 μm or greater per square centimeter; even 5 or fewer surface features of 1-10 μm or greater per square centimeter. Here as elsewhere in the specification and claims, ranges can be combined to form new and non-specified ranges.

(20) The surface feature density is evaluated using an optical microscope on an intact container. The microscopy is conducted through the wall by focusing on the inner surface of the container. Imaging is conducted on a 1 cm band centered 1 cm up from the base of the vial. Imaging may be conducted using any suitable optical microscope. In one embodiment, imaging is performed with a Keyence optical microscope at a magnification of 450×; and a camera having a field of view of approximately 575 micron by 775 micron. Imaging is done at five random areas located within the 1 cm band. In each image, the number of surface features that had a dimension length of greater than approximately 10 μm is counted.

(21) Also provided is a method for manufacturing fused quartz glass containers having low concentrations of surface features. The method is fully automatable and may allow for high throughput production of fused glass containers having a low concentration of redeposited features of volatile glass constituents.

(22) The method begins by forming desired external features of the container such as, for example, the mouth, crown, neck, shoulder, etc., on one end of a glass tube. The method disclosed relies on equipment that is configured in order to allow the following steps to take place. First, a glass tube is automatically transferred into a rotating chuck on either an index forming or continuous forming machine. The machine then begins by forming desired external features of the container, such as, for example, the mouth, crown, neck, shoulder, etc. on one end of the glass tube. The formation of the external features may be performed in a manner similar to conventional forming techniques, whereby the glass is heated up, and the shape is crafted by pressing with suitable tooling on both the inner diameter and the outer diameter. In accordance with the present method, these features are formed onto a shorter segment than in a conventional forming method, and the length of the tube is approximately twice as long as necessary to produce one vial. Once the desired features are formed, the tube is reversed in orientation such that the end that has not yet been worked is facing outward. This can be done by either extracting, flipping, and returning the part into the chuck, or alternatively, in the process of passing the tube from one chuck to another. Similar features are then formed on the opposite end of the tube using similar processing steps, to result in a double-headed container. During formation of the features at either end of the tube, the quartz tube may be purged by application of a gas to the tube. In an embodiment, the gas is a clean gas and flow rate of the gas may be selected as desired. A clean gas may be understood as a gas that is free of or substantially free of solid particulates and/or liquid and/or gaseous contaminates that could potentially lead to particulate or residue generation. In one embodiment, the clean gas is an inert gas. Suitable gases include, but are not limited to air, helium, nitrogen, argon, carbon dioxide, methane, etc., or a combination of two or more thereof. This double headed container is then separated in two during a single bottom forming step using a flame. Careful control of both torch heating, as well as rotational control on each end of the tube result in a pair of consistently formed bottoms and two newly separated parts. Thus, two vials are formed from a single bottom forming step without the need to puncture a solid base or near solid base to form the opening for the new mouth as is the case in conventional approaches. This process can be practiced in either the vertical orientation, the horizontal orientation, or even in an orientation between the two (angled). The invention can also be used with purge and/or plugging approaches as well.

(23) Further, with a sufficient degree of automation that is familiar to one skilled in the art, the process allows for high throughput process and can process greater than 50 pieces per hour; greater than 75 pieces per hour; greater than 100 pieces per hour; greater than 250 pieces per hour; greater than 500 pieces per hour; greater than 1000 pieces per hour; greater than about 2000 pieces per hour; even up to about 3000 pieces per hour. Further, with a sufficient degree of automation that is familiar to one skilled in the art, the process allows for high throughput process and can process greater than 50 pieces per hour; greater than 75 pieces per hour; greater than 100 pieces per hour; greater than 250 pieces per hour; greater than 500 pieces per hour; greater than 1000 pieces per hour; greater than about 2000 pieces per hour; even up to about 3000 pieces per hour.

(24) The method can be implemented on one or more of various styles of automatic forming equipment used in tubular glass container manufacturing. As would be known in the art, such equipment typically includes, but is not limited to glass and container-transferring equipment, which can incorporate vacuum, pneumatic, hydraulic, robotic and/or servo-driven pick and place tooling and conveyors. Additionally, the equipment is often configured with rotating chucks that 1) grip glass tubes, 2) rotate to ensure symmetric heating and fabrication, and 3) can carry glass tubes through one or more sequences of fabrication steps. Carrying can be performed in a stop/start or indexing fashion (index forming), where fabrication steps are performed at discrete locations and the index motions take place at a prescribed frequency. Alternatively, carrying can be performed in a continuously rotating fashion, where tooling can travel alongside the traveling glass as fabrication steps take place (continuous forming). In both cases, the intention is to produce highly reproducible parts at high fabrication rates with minimal operator interaction. Automatic equipment may also employ pneumatic, hydraulic, spring or servo-motor driven tooling in order to apply pressure to shape the glass, as well as gas burners to heat the glass. Such burners may or may not have flow control devices for controlling one or more of fuel and oxidizer flow.

(25) What has been described above includes examples of the present specification. It is, of course, not possible to describe every conceivable combination of components or methodologies for purposes of describing the present specification, but one of ordinary skill in the art may recognize that many further combinations and permutations of the present specification are possible. Accordingly, the present specification is intended to embrace all such alterations, modifications and variations that fall within the spirit and scope of the appended claims. Furthermore, to the extent that the term “includes” is used in either the detailed description or the claims, such term is intended to be inclusive in a manner similar to the term “comprising” as “comprising” is interpreted when employed as a transitional word in a claim.

EXAMPLES

(26) A fused quartz glass article was prepared in a conventional manner by one skilled in the art, without incorporating any of the steps outlined herein to avoid glass constituent redeposit. Shown in FIG. 2 is an example region of said article showing four adhered glass particles greater than 10 μm in length. With the frame of the picture capturing approximately 0.0045 cm.sup.2, this would represent approximately 900 particles per square cm. This is compared with an article made incorporating the steps outlined herein where no such particles are seen (Shown in FIG. 3). A selection of Type I borosilicate vials were assembled representing industry benchmarks for larger volume vials (20 ml and 50 ml). These were made by three different manufacturers located in the US and Europe. These were examined “as manufactured”, with none of them having received ammonium or other post-process treatment. While details of manufacturing operations are proprietary to each manufacturer, it is expected that each of these has passed an inspection criteria meant to sort out defective products. Larger vial sizes (20 and 50 ml) were selected intentionally as it is understood in the industry that redeposited particles are especially challenging for the larger vials as they require more heat to form. Thus this size selection is expected to amplify the number of surface features present.

(27) 50 ml Fused quartz glass vials are prepared as follows: 1) clean quartz glass tubing of 40 mm outer diameter and approximately 160-180 mm in length, open on both ends, is fed into automated vial forming equipment. 2) Geometric features related to the mouth, crown, neck and shoulder are formed on one of the two open ends in an automated, controlled fashion, applying heat by means of torches and pressing the glass with glass-working tooling whilst the tube is being rotated about its axis, while a centerline inert gas purge is being applied. 3) A similar process is repeated on the other open end located on the opposite side of the tube. 4) A separation step is performed using torch applied heat and controlled pulling and pressing whilst the tube is being rotated about its axis. This separation step also results in the formation of bottoms for both pieces. At this point the pieces demonstrate that they have a greatly reduced number of redeposited glass particles (or preferably and more typically no such particles). The articles then pass through an outer surface cleaning process, which while has no impact on the inner surface of the glass, does make the outer surface of the glass easier to see through.

(28) Vials were examined in their whole state (un-cut), using a Keyence optical microscope at a magnification of 450×. The vials were preserved intact, and the microscopy was done through-the-wall by focusing on the inner surface in order to avoid possible sample contamination/altering during sectioning. The focal plane of the inner surface was validating to ensure that it corresponded to the correct wall thickness. The field of view of the camera used with the microscope was approximately 575 micron by 775 micron area.

(29) Each of the borosilicate vials had regions near the base with surface features in the 5-50 micron range, although in many cases the smallest of those (<10 micron) were much too frequent to count and difficult to resolve anyway. Thus, only particles >10 microns were counted, as these were more clearly correlated with previous literature. This greatly reduced the amount of image analysis as over 90% of the particles were smaller than this cut off length.

(30) At least 5 microscope images/areas were selected for each sample vial (at least 10 for each fused quartz vial). The imaging areas were located in random locations within a 1 cm band centered 1 cm up from the base of the vial. Each of these images represents about 0.3% of the area contained within the band. In each image, the number of redeposited glass particles or features resulting from redeposited volatile glass constituents that had a length dimension of greater than approximately 10 micron were counted. The number of particles greater than 10 micron per image ranged from 0 (most common) up to 39 (less common). Interestingly, many of the images with 0 particles in this size category did not contain any discernable particles or features of interest, while some contained an enormous amount of features in the <10 micron range. No features of this type were observed in any of this particular set of fused quartz vials, even after examining about twice as many locations as the other vials.

(31) The three borosilicate vial types had relevant densities of approximately 9, 23 and 12 particles greater than 10 microns per square mm (907, 2308, and 1222 particles greater than 10 microns per square cm respectively) within the specified 1 cm band. Since no features were found on the fused quartz vial during this testing, a single fictitious particle is used in calculations to result in a density of less than 0.04 particles greater than 10 microns per square mm (<4 particles per square cm) within the same 1 cm band. This represents a >99.4% reduction (greater than 2 orders of magnitude) in the frequency of such features in this region.

(32) In addition to the images counted above, a course evaluation of approximately 1% (2% in the case of the fused quartz) of the remainder of the vial inner body inner surface was performed to look for evidence of larger particles (>50 microns) in other regions of the vial outside of this band. Here the borosilicate vials had 2, 1 and 0 such particles per vial respectively, while no such particles were found on the fused quartz vials.

(33) TABLE-US-00001 Vial Size Samples analyzed Area analyzed Particles* Area density (ml) # (cm.sup.2) (count) (particles*/cm.sup.2) Vendor A, Type I Borosilicate 50 4 0.11 97 907 Vendor B, Type I Borosilicate 50 5 0.12 288 2308 Vendor C, Type I Borosilicate 20 5 0.12 147 1222 Fused Quartz, current invention 50 5 0.22 0 (less than 4) *Particles definition used here includes redeposited glass particles and features resulting from the redeposit of volatile glass consituents with a linear dimension of greater than 10 microns.

Comparative Example

Quartz Glass Tube

(34) Tests were performed using a conventional approach to tubular vial forming. The test was aimed at producing 2 ml vials using a standard rotary-index based, vertically-oriented, tubular-vial manufacturing machine that was developed for borosilicate vials, although some minor alterations were made to the gas burner units in order to accommodate the higher required working temperatures of fused quartz glass. The input to the process was 16 mm fused quartz tubes, approximately 1 m in length. The equipment was running at a rate sufficient to produce approximately 30 vials a minute (1800 vials per hour). FIGS. 4 and 5 show a vial made by this process. As shown in the FIGS. 4 and 5, the containers have a white/frosty appearance. This is evidence of prominent and extremely numerous surface features on both the interior and exterior of the vial. As such, the number of features in the region of interest are too numerous too count.

(35) FIG. 6 compares the vial of the Comparative Example (FIG. 6(a)) with a vial made in accordance with the present method (FIG. 6(b)). The vial of FIG. 6(b) is substantially more clear in appearance due to the low surface features.

(36) The foregoing description identifies various, non-limiting embodiments of a pharmaceutical container and methods of making the same. Modifications may occur to those skilled in the art and to those who may make and use the invention. The disclosed embodiments are merely for illustrative purposes and not intended to limit the scope of the invention or the subject matter set forth in the claims.