Nanoparticles, methods for producing nanoparticles and nanoparticle generators

Abstract

Compositions are provided that can include nanoscale particles including metal cations such as cerium having an average particle size of less than 10 nm. The nanoscale particles can include cerium and oxygen. Methods for forming nanoparticles are provided. The methods can include exposing a metal cation within a solution to radiation to form metal nanoparticles that can include metal cations. The methods can include exposing a cerium salt solution to radiation to form the nanoparticles. The methods can include exposing solvated metal cations to radiation to precipitate nanoparticles that include metal cations such as Ce. The methods can include exposing the homogeneous solution to radiation to precipitate nanoparticles. The methods can include: providing an aqueous solution comprising metal cations; and increasing the pH of the aqueous solution with radiation to form nanoparticles that include metal cations. Nanoparticle generators are provided. The generators can include: a reactant reservoir comprising a metal cation in solution; a fluid cell in fluid communication with the reactant reservoir; a radiation source operatively aligned with the fluid cell; and a product reservoir in fluid communication with the fluid cell.

Claims

1. A method for forming nanoparticles, the method comprising: exposing a cerium salt solution to an electron beam to form cerium nanoparticles having a particle size between 1 and 4 nm.

2. The method of claim 1 wherein the cerium salt comprises Ce Ill.

3. The method of claim 1 wherein the cerium salt is present in the solution in an amount of at least 0.1 mM.

4. The method of claim 1 wherein the cerium salt solution has a pH below 7.

5. The method of claim 1 wherein the cerium salt solution comprises nitrate.

6. The method of claim 1 wherein the cerium within the cerium salt solution has the same valence state as the cerium comprised by the nanoparticle.

7. The method of claim 1 further comprising raising the pH of the solution upon formation of the nanoparticle.

8. The method of claim 1 wherein the electron beam is 80.5 pA.

Description

DRAWINGS

(1) Embodiments of the disclosure are described below with reference to the following accompanying drawings.

(2) FIG. 1 is an example nanoparticle generator according to an embodiment of the disclosure.

(3) FIG. 2 is an example nanoparticle generator and/or method according to an embodiment of the disclosure.

(4) FIG. 3 is STEM imagery of reaction products, particle distribution, and monocrystalline Ce(OH).sub.3.

(5) FIG. 4. includes snapshots to, 85 sec., and 335 sec.; reaction products, and high resolution imagery of Ce(OH).sub.3.

DESCRIPTION

(6) This disclosure is submitted in furtherance of the constitutional purposes of the U.S. Patent Laws to promote the progress of science and useful arts (Article 1, Section 8).

(7) The compositions, methods, and generators will be described with reference to FIGS. 1-4. Referring first to FIG. 1, a generator 10 is depicted for example purposes and use in describing nanoparticles generators and methods of forming nanoparticles according to embodiments of the disclosure. Generator 10 can include a reactant reservoir 12 that can contain and/or transport a metal cation in solution. In fluid communication with reservoir 12 can be fluid cell 14, which can also be in fluid communication with product reservoir 18. Fluid cell 14 can also be considered a fluid stage. Operatively aligned with fluid cell 14 can be a radiation source 16. Generator 10 and methods can be operated in batch or flow as desired. To facilitate batch or flow operations valves 20 and 22 can be manipulated to provide reactants to fluid cell 14 and/or products from product reservoir 18. Additionally, radiation source 16 can be operated with an on/off switch 23 as nanoparticle generation is desired. In accordance with example implementations, radiation source 16 includes operator controls configured to allow on-demand radiation to fluid cell 14. Solution from the reactant reservoir can be irradiated from the radiation source with e-beams, x-rays, nuclear radiation, gamma rays, and/or alpha particles to provide radiolysis. This irradiation can be manipulated to provide the nanoparticles on demand. As an example, the precursor solutions can be irradiated using 300 kV electron beam provided from a scanning transmission electron microscope (STEM).

(8) In at least one example implementation, product reservoir 18 can be operatively coupled to a nanoparticle administration assembly (not shown) via valve 22.

(9) With reference to FIG. 2, an example generator and/or method for producing cerium nanoparticles are provided. As a generator of nanoparticles, the generator can provide a precursor solution that can be irradiated to form the nanoparticles of the present disclosure.

(10) Methods for forming the nanoparticle compositions of the present disclosure can include methods of forming nanoparticles, methods of forming nanoparticles that include metal cations such as cerium, methods of forming nanoparticles that can include cerium and oxygen, and/or methods of precipitating nanoparticles from homogeneous solutions.

(11) One or more of the methods can include providing an aqueous reactant solution. The aqueous reactant solution can include a cation such as a metal cation. The cation may be associated with an anion and together the cation and anion can form a salt of the metal cation. The solution can be homogeneous in that the solution is entirely liquid without precipitates. In accordance with example implementations, the cations can be solvated within the solution. The solution can have an acidic pH, or a pH below 7, for example, but may also have a neutral or basic pH, or a pH above 7.

(12) The reactant solution can include a Ce cation such as Ce III cation. The cation of the solution can be associated with a nitrate anion(s). The reactant solution can be, for example, Ce(III)nitrate in deionized water (Ce(NO.sub.3).sub.3.6H.sub.2O). The salt can be provided at a concentration of 0.1 mM. The pH of the reactant solution can be 5.2.

(13) In accordance with example implementations, the reactant solution can be exposed to radiation. Radiolysis of the reactant solutions can be initiated with ionizing radiation for example. The primary species produced by the radiation of H.sub.2O are: e.sup.(aqueous), H.sub.3O.sup.+, H.sup., OH.sup., H.sub.2, H.sub.2O.sub.2 and HO.sub.2. Conventionally, radiolysis of water leads to pH changes to lower values, i.e., becoming more acidic. In accordance with the present disclosure, exposing the reactant solution to radiation can raise the pH of the solution to a higher pH, for example, from acidic (below 7) to less acidic, from acidic to basic (above 7) and/or from basic to more basic. Example exposures can change the pH from about 5.2 to about 7.2. The pH may also be changed to as high as 10 or higher, for example.

(14) Exposure of the homogenous reactant solution to radiation can precipitate nanoparticles from the homogenous solution thereby generating a heterogeneous solution having particles. Conventional metal cations in solution, exposed to radiolytic conditions, lead to particles having metals with a zero valency. In accordance with the present disclosure, the particles formed can be nanoparticles have a metal ion, or a charged state such as a metal cation. The nanoparticles formed can include metal cations of the same valence as the metal cations of the reactant solutions, for example. Accordingly, a III cation in solution can be used to generated a III cation of the nanoparticle. More specifically, Ce III cations of the reactant solution can be part of nanoparticles that can include Ce III cations. Some or all of the Ce of the nanoparticles can have a III valence state while some of the particles may have a IV valence state. The nanoparticles can include the ion and oxygen, such as cerium and oxygen.

(15) In accordance with example implementations of the method, at low beam dose (dose rate of 4 e.sup./.sup.2 per frame and beam current of 6 pA) no particle growth was observed in situ even upon extended irradiation. At sufficient dose, in situ nanoparticle formation in the beam area is observed. Starting with cerium (III) nitrate at 0.1 mM concentration, the electron beam current was increased from 6 pA to 80.5 pA, while keeping the electron dose rate at 4 e.sup./.sup.2 per frame. Particles were observed by in situ TEM to form in solution with sizes being in the 1-4 nm range and a mean diameter of 2.9 nm.

(16) Results for particle growth in the electron beam are shown in FIGS. 3 and 4. Growth of individual nanoparticles is shown in FIG. 3: (a) Dark Field STEM image showing the reaction products of a growth experiment using the Ce(III) precursor solution. An electron beam current of 80.5 pA; Magnification 40,000; Pixel dwell time: 3 s were used to give an electron dose rate of 4.4 e.sup./.sup.2 per frame. (b) Particles size distribution included a total of 279 particles in the analysis. The minimum diameter measured was 1.9 nm; median: 2.8 nm; mean value: 2.9 nm; max value: 4.342 nm; standard deviation: 0.5 nm. (c) Particles are monocrystalline Ce(OH)3.

(17) Extended irradiation leads to particle coalescence and reorientation as shown in FIG. 4; hence, the dose rate and time influence the final nanoparticle characteristics. FIG. 4 (a) Snapshots of a dark field (DF) STEM in situ movie of the particles in solution showing that extended irradiation times produce particle mediated growth. FIG. 4 (b) Reaction products of the growth experiments showing that brighter areas are particles that undergo coalescence, resulting on an increased particle size, especially in more populated areas. They also reorient themselves along with the electron beam. FIG. 4 (c) High resolution TEM (HRTEM) image showing a detail of the areas where agglomeration has occurred. FFT showing the Ce(OH).sub.3 structure.

(18) After dismantling and drying the sample, images were taken and fast Fourier transform (FFT) was used to determine diffraction features from the sample images. The solids formed in the irradiated area were determined to be of hexagonal structure, corresponding to Ce(OH).sub.3. The brightest spots of the FFT are the (102) family of planes of the hexagonal Ce(OH).sub.3 structure. (Note: Ce.sub.2O.sub.3 and Ce(OH).sub.3 are isostructural and have very similar lattice constant, but Ce.sub.2O.sub.3 is very unstable and unlikely to be formed.) Only the irradiated area on the SN.sub.x membrane surface was covered with Ce(OH).sub.3 particles. Non irradiated areas examined after dismantling and drying were found to have CeO.sub.2/Ce(OH).sub.4 precipitates present. Control experiments show that these CeO.sub.2/Ce(OH).sub.4 precipitates arise as artifacts of dismantling and drying, rather than as radiolytic products.

(19) Therefore, the particles formed in situ, only in the irradiated area, are attributed to radiolytic processes and identified as Ce(OH).sub.3 nanoparticles, containing Ce and Oxygen atoms, where there are Ce atoms in the Ce(III) valence state.

(20) In accordance with at least the methods provided herein compositions are provided. The compositions can include nanoparticles that can include cerium and oxygen and have an average particle size of less than 10 nm. The nanoparticles can include cerium in the III and/or IV valence states. However, the cerium III composition of the nanoparticles can be greater than the cerium IV composition.

(21) The nanoparticles can be nanoscale particles that can include metals such as metal cations. The metal can be Ce and the cation can be Ce III and/or Ce IV. The particles can further include oxygen, such particles can include cerium and oxygen. For example, the particles can include cerium III hydroxide. These nanoparticles can have an average particle size of less than 5 nm or an average particle size of 1-4 nm or even a mean particle size of 2.9 nm.

(22) These nanoparticles can be nanoscale particles and can include cerium and oxygen. The Ce of the nanoparticle can be of the Ce(III) variety, such as Ce(OH).sub.3. The nanoparticle may also contain both Ce(III) and Ce(IV), with the Ce(III) being the predominant species. The nanoparticles can be nanoscale particles that include metal ions, and can be bio medically therapeutic nanoparticles.

(23) In compliance with the statute, embodiments of the invention have been described in language more or less specific as to structural and methodical features. It is to be understood, however, that the entire invention is not limited to the specific features and/or embodiments shown and/or described, since the disclosed embodiments comprise forms of putting the invention into effect.