METHOD FOR TREATING CORONAVIRUS INFECTIOUS DISEASE AND COMPLICATED SEVERE COMA, ULTRA-LOW BLOOD OXYGEN, MORIBUND DISEASE THEREOF

Abstract

The present invention relates to a method for treating a coronavirus infectious disease and a complication thereof, including: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture including Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, and Rhei radix et rhizoma.

Claims

1. A method for treating a coronavirus infectious disease and a complication thereof; comprising: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture comprising Ephedra sinica, Armeniacae Semen amarum, Glycyrrhizae radix et Rhizoma, Gypsum fibrosum, Descurainiea semen, stephaniae Tetrandrae radix, Scutellariae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, and Rhei radix et rhizoma

2. The method of claim 1, wherein the Chinese medicine composition is prepared by the following steps: providing the first mixture; mixing the first mixture with water to form a second mixture; heating the second mixture to obtain a crude extract; and filtering the crude extract and keep a liquid extract to obtain the Chinese medicine composition.

3. The method of claim 1, wherein the first mixture comprises 2-4 parts by weight of Ephedra sinica, 7-9 parts by weight of Armeniacae Semen amarum, 4-6 parts by weight of Glycyrrhizae radix et rhizoma, 7-9 parts by weight of Gypsum fibrosum, 7-9 parts by weight of Descurainiea semen, 4-6 parts by weight of Stephaniae Tetrandrae radix, 7-9 parts by weight of Scutellariae radix, 7-9 parts by weight of Poria, 3-5 parts by, weight of Rhizoma alismatis, 3-5 parts by weight of Polyporus umbellatus, 3-5 parts by weight of Atractylodis rhizoma, 3-7 parts by weight of Asteris radix et rhizoma, 3-7 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma, and 2-4 parts by weight of Rhei radix et rhizoma

4. The method of claim 3, wherein the part by weight of the first mixture is 2.5-5 gram per part.

5. The method of claim 1, wherein the first mixture further comprises at least one ingredient selected from the group consisting of Ginseng radix et rhizoma and Anredera Cordifolia.

6. The method of claim 5, therein the first mixture further comprises at least one ingredient selected from the group consisting of 1-3 parts by weight of Ginseng radix et rhizoma and 1-3 parts by weight of Anredera cordifolia.

7. The method of claim 6, wherein the part by weight of the first mixture is 2.5-5 gram per part.

8. The method of claim 1, wherein the first mixture further comprises Ginseng radix et rhizoma and Anredera cordifolia.

9. The method of claim 8, wherein the first mixture comprises 2-4 parts by weight of Ephedra sinica, 7-9 parts by weight of Armeniacae Semen amarum, 4-6 parts by weight of Glycyrrhizae radix et rhizoma, 7-9 parts by weight of Gypsum fibrosum, 7-9 parts by weight of Descurainiea semen, 4-6 parts by weight of Stephaniae Tetrandrae radix, 7-9 parts by weight of Scutellariae radix, 7-9 parts by weight of Poria, 3-5 parts by weight of rhizoma alismatis, 3-5 parts by weight of Polyporus umbellatus, 3-5 parts by weight of Atractylodis rhizoma, 5-7 parts by weight of Asteris radix et rhizoma, 5-7 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma, 2-4 parts by weight of Rhei radix et rhizoma, 1-3 parts by weight of Ginseng radix et rhizoma and 1-3 parts by weight of Anredera cordifolia.

10. The method of claim 1, wherein the coronavirus is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

11. The method of claim 1, wherein the Chinese medicine composition is administered via oral administration or injection.

12. The method of claim 1, wherein the Chinese composition further comprises pharmaceutically acceptable carrier, stabilizer, diluent, dispersant, suspending agents, thickening agent, excipient, or the combination thereof.

13. A method for treating a coronavirus infectious disease and a complication thereof; comprising: administering a Chinese medicine composition to a subject in need thereof; wherein, the Chinese medicine composition is an extract of a first mixture comprising Ephedra sinica, Armeniacae Semen amarum, Scutellariae radix, Poria, Atractylodis rhizoma, Asteris radix et rhizoma, Tussilago farfara, Pinelliae rhizoma, Ginseng radix et rhizoma, Anredera Cordifolia, Salviae Miltiorrhizae radix et rhizoma, radix Glycyrrhizae, Aucklandiae radix, Amomi fructus, Schisandra Chinensis, Citri reticulatae pericarpium, Ginkgo semen, Dioscoreae rhizoma, Pimento officinalis, Zingiberis rhizoma, and Aconiti Lateralis radix Praeparata.

14. The method of claim 13, wherein the Chinese medicine composition is prepared by the following steps: providing the first mixture; mixing the first mixture with water to form a second mixture; heating the second mixture to obtain a crude extract; and filtering the crude extract and keep a liquid extract to obtain the Chinese medicine composition.

15. The method of claim 13, wherein the first mixture comprises 2-4 parts by weight of Ephedra sinica 3-5 parts by weight of Armeniacae Semen amarum, 7-9 parts by weight of Scutellariae radix, 2-4 parts by weight of Poria, 2-4 parts by weight of Atractylodis rhizoma, 3-5 parts by weight of Asteris radix et rhizoma, 3-5 parts by weight of Tussilago farfara, 3-5 parts by weight of Pinelliae rhizoma, 2-4 parts by weight of Ginseng radix et rhizoma, 2-4 parts by weight of Anredera cordifolia, 2-4 parts by weight of Salviae Miltiorrhizae radix et rhizoma, 2-4 parts by weight of radix glycyrrhizae, 2-4 parts by weight of Aucklandiae radix, 2-4 parts by weight of Amomi fructus, 2-4 parts by weight of Schisandra chinensis, 3-5 parts by weight of Citri reticulatae pericarpium, 3-5 parts by weight of Ginkgo semen, 4-6 parts by weight of Dioscoreae rhizoma, 4-6 parts by weight of Pimenta officinalis, 4-6 parts by weight of Zingiberis rhizoma, and 4-6 parts by weight of Aconiti lateralis radix praeparata.

16. The method of claim 15, wherein the part by weight of the first mixture is 2.5-5 gram per part.

17. The method of claim 13, wherein the coronavirus is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18. The method of claim 13, wherein the Chinese medicine composition is administered via oral administration or injection.

19. The method of claim 13, wherein the Chinese composition further comprises pharmaceutically acceptable carrier, stabilizer, diluent, dispersant, suspending agents, thickening agent, excipient, or the combination thereof.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

[0022] The following embodiments are meant to explain the implementation of the present invention, they should be construed as descriptive merely, and should not restrict the remaining part of the present invention. The person having ordinary skills in the art can easily understand other advantages and effects of the present invention. The present invention may also be implemented or applied by other different embodiments, and various details in this specification may also be modified and changed according to different viewpoints and applications without departing from the spirit of the invention.

[0023] Unless specified otherwise, all technical and scientific terms described in the specification and claims of the present invention are defined by the following definition. In the present invention, the singular term and the, may refer to one or more object(s), unless specified otherwise. In addition, the term comprise is an open-ended transition word which does not limit to the items listed. The foregoing paragraphs are only systematic references and should not be construed as limitations for the subject of the invention. Unless specified otherwise, the materials used in the present invention are commercially available and easy to obtain. Possible sources for obtaining the materials are listed below and it is exemplary only.

[0024] In the following preparation examples, the part by weight is 3.75 gram per part.

Preparation Example 1

[0025] Three parts by weight of Ephedra sinica, 8 parts by weight of Armeniacae Semen amarum, 5 parts by weight of Glycyrrhizae radix et rhizoma, 8 parts by weight of Gypsum fibrosum, 8 parts by weight of Descurainiea semen, 5 parts by weight of Stephaniae Tetrandrae radix, 8 parts by weight of Scutellariae radix, 8 parts by weight of Poria, 4 parts by weight of rhizoma alismatis, 4 parts by weight of Polyporus umbellatus, 4 parts by weight of Atractylodis rhizoma, 4 parts by weight of Asteris radix et rhizoma, 4 parts by weight of Tussilago farfara, 4 parts by weight of Pinelliae rhizoma, and 3 parts by weight of Rhei radix et rhizoma were provided to form a mixture, added with 1500 parts by weight of water, and heated for 1 hour to form a crude extract of about 400 parts by weight. The crude extract was filtered and the filtrate was collected to obtain a first extract of the present embodiment. In addition, Descurainiea semen, Stephaniae Tetrandrae radix, Poria, rhizoma alismatis, Polyporus umbellatus, Atractylodis rhizoma, Pinelliae rhizoma were used to alleviate pleural effusion, allowing the mucus and water in the pleura or trachea to be diluted, exuded and exuded back. Furthermore, Gypsum fibrosum and Scutellariae radix were used to reduce inflammation, suppress immune hyperactivity, and avoid inflammation of the trachea and throat. Moreover, Rhei radix et rhizoma was used to reduce abdominal pressure and dissolve thrombus. The effects of the same ingredients would not be described hereinafter.

Preparation Example 2

[0026] The present preparation example was similar to Preparation Example 1, except that the mixture was further added with 2 parts by weight of Asteris radix et rhizoma, 2 parts b weight of Tussilago Farfara, 1.6 parts by weight of Ginseng radix et rhizoma, 1 parts by weight of Anredera Cordifolia. Then, the extraction process thereof was performied according to an extraction process similar to Preparation 1, thereby obtaining a second extract of the present preparation example. The abilities of blood exchange and oxygen exchange were improved by Ginseng radix et rhizoma and Anredera cordifolia, wherein Ginseng radix et rhizoma was used to increase the oxygen level in blood. In addition, the dosages of Asteris radix et rhizoma and Tussilago farfara were increased for improving and discharge the sick sputum. The effects of the same ingredients would not be described hereinafter.

Preparation Example 3

[0027] Three parts by weight of Ephedra sinica, 4 parts by weight of Armeniacae Semen amarum, 8 parts by weight of Scutellariae radix, 3 parts by weight of Poria, 3 parts by weight of Atractylodis rhizoma, 4 parts by weight of Asteris radix et rhizoma, 4 parts by weight of Tussilago farfara, 4 parts by weight of Pinelliae rhizoma, 3 parts by weight of Ginseng radix et rhizoma, 3 parts by weight of Anredera cordifolia, 3 parts by weight of Salviae Miltiorrhizae radix et rhizoma, 3 parts by weight of radix glycyrrhizae, 3 parts by weight of Aucklandiae radix, 3 parts by weight of Amomi fructus, 3 parts by weight of Schisandra chinensis, 4 parts by weight of Citri reticulatae pericarpium, 4 parts by weight of Ginkgo semen, 5 parts by weight of Dioscoreae rhizoma, 5 parts by weight of Pimenta officinalis, 5 parts by weight of Zingiberis rhizoma, and 5 parts by weight of Aconiti lateralis radix praeparata were provided to form a mixture. Then, the extraction process thereof was performed according to an extraction process similar to Preparation 1, thereby obtaining a third extract of the present preparation example. Furthermore, Ginkgo semen and Schisandra chinensis could improve cardiopulmonary function and had the ability to stabilize or increase blood oxygen level. In addition to the above functions, Schisandra chinensis could also avoid the symptoms of drug-induced hepatitis or liver failure.

Example 1

[0028] The patient of Example 1 suffered from COVID-19 with multiple pulmonary ground glass opacities in both lungs, and the chest X-ray showed opacity.

[0029] A treatment of the present embodiment applied to the patient of Example 1 was described below. A daily dose of the first extract of Preparation Example 1 was administered to the patient every day from the first day; wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pulmonary ground glass opacities were significantly alleviated, and the alveolar infiltrates were significantly improved.

Example 2

[0030] The patient of Example 2 suffered from COVID-19 with pleural effusion.

[0031] A treatment of the present embodiment applied to the patient of Example 2 was described below. A daily dose of the first extract of Preparation Example 1 was administered to the patient every day from the first day, wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, and the mucus and water in the pleura and trachea could exude and exude back normally.

Example 3

[0032] The patient of Example 3 suffered from COVID-19 with pleural effusion, and complicated by anemia concurrently.

[0033] A treatment of the present embodiment applied to the patient of Example 3 was described below, A daily dose of the first extract of Preparation Example 1 was administered to the patient every day from the first day wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, and the complication was in complete remission.

Example 4

[0034] The patient of Example 4 suffered from COVID-19 with pleural effusion, and the patient's blood oxygen was below 80 mmHg (the normal value of blood oxygen was higher than 95 mmHg).

[0035] A treatment of the present embodiment applied to the patient of Example 4 was described below. A daily dose of the first extract of Preparation Example 1 was administered to the patient every day from the first day; wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, the blood oxygen was increased to higher than 85 mmHg, and the blood circulation and blood oxygen level were improved.

Example 5

[0036] The patient of Example 5 suffered from COVID-19 with pleural effusion, the blood oxygen was below 80 mmHg, and the amount of oxygen used for intubation was reduced by 50%.

[0037] A treatment of the present embodiment applied to the patient of Example 5 was described below. A daily dose of the second extract of Preparation Example 2 was administered to the patient every day from the first day, wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, and the blood oxygen was increased to higher than 95 mmHg.

Example 6

[0038] The patient of Example 6 suffered from COVID-19 with pleural effusion, blood oxygen was below 80 mmHg, and was complicated by hypoxemia.

[0039] A treatment of the present embodiment applied to the patient of Example 6 was described below A daily dose of the second extract of Preparation Example 2 was administered to the patient every day from the first day; wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, the blood oxygen was increased to higher than 95 mmHg, and the complication was in complete remission.

Example 7

[0040] The patient of Example 7 suffered from COVID-19 with pleural effusion, and was complicated by hypokalemia and hypoxemia concurrently.

[0041] A treatment of the present embodiment applied to the patient of Example 7 was described below. A daily dose of the third extract of Preparation Example 3 was administered to the patient every day from the first day, wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, and the complications were in complete remission.

Example 8

[0042] The patient of Example 8 suffered from COVID-19 with pleural effusion, blood oxygen was below 80 mmHg, and GOP and GPT thereof were 38 LI/L (the normal value of GOP was below 40 LI/L) and 79 UM (the normal value of GPT was below 40 U/L), respectively.

[0043] A treatment of the present embodiment applied to the patient of Example 8 was described below. A daily dose of the third extract of Preparation Example 3 was administered to the patient every day from the first wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, blood oxygen was increased to higher than 95 mmHg, and liver injury indicators were back to normal.

Example 9

[0044] The patient of Example 9 suffered from COVID-19 with pleural effusion, the blood oxygen was once as low as 39.5 mmHg, and the foot embolism thereof showed black.

[0045] A treatment of the present embodiment applied to the patient of Example 9 was described below. A daily dose of the third extract of Preparation Example 3 was administered to the patient every day from the first day, wherein the daily dose of the first extract was divided into aliquots for ter in die administration. A follow-up report indicated that pleural effusion was in complete remission, blood oxygen was increased to higher than 95 mmHg, and the foot embolism was in complete remission.

[0046] Although the present invention has been explained in relation to its preferred embodiment, it is to be understood that many other possible modifications and variations can be made without departing from the spirit and scope of the invention as hereinafter claimed.