Brain Cooling Method and Portable Device

Abstract

A noninvasive, brain cooling method and device for cerebral cooling via a patient's nasopharyngeal cavity, is described. Thermal conductive nasal prongs are inserted into a nasal cavity and are cooled by thermoelectric cooling elements. An outward air driving fan inside the device drives a cold air current through the nasal and oral cavities. Heat transfer between the cold air and the surface of the nasal cavity cools the nasal cavity, which in turn, cools a patient's brain. Real-time temperature sensing data provides feedback for closed-loop cooling control.

Claims

1. A noninvasive cooling method for brain damage prevention, comprising following steps: inserting nasal prongs into a nasal cavity of a patient through nostrils, the nasal prongs comprising a thermal conductive surface; inserting an oral tube into oral cavity of a patient through mouth, the oral tube is a hollow member comprising a proximal end, a distal end, and an outward air driving fan positioned at the distal end; inserting temperature sensors into patient's ears; delivering a cooled air flow onto a surface of the patient's nasal cavity through the cold surface of the nasal prongs for a period of between minutes to hours; wherein the cooled airflow is circulated within the nasal and oral cavities and wherein the substantially cold air exchange heat with the surface of nasal cavity to reduce the cerebral temperature of the patient to a protective temperature range.

2. The method of claim 1, wherein the cold air is substantially environmental air, oxygen, or other suitable gas.

3. The method of claim 1, wherein the step of delivering the moderate cold air is administered first to reduce the patient's cerebral temperature moderately and the step of colder air is initiated subsequently to further reduce the patient's cerebral temperature to within the set temperature range.

4. The method of claim 3, wherein the step of delivering the moderate cold air is administered to maintain the patient's cerebral temperature within the set temperature range to prevent rewarming of cerebral temperature of the patient.

5. The method of claim 4, further comprising repeating the step of delivering the moderate cold air onto the surface of the patient's nasal cavity through the nostrils and the cold nasal prongs for the certain period of time to maintain the reduced cerebral temperature or prevent rewarming during transition to a systematic cooling method.

6. The method of claim 5, wherein the method occurs for some time, ranging from minutes to hours during the transitioning of the patient from nasal cooling to other systemic cooling methods.

7. The method of claim 6, wherein the systemic cooling comprises surface cooling or intravascular cooling.

8. The method of claim 1, wherein the cold air is cooled by a solid state cooling element or other alternative cooling methods or their combinations.

9. A noninvasive cooling method for brain damage prevention, comprising following steps: inserting nasal prongs into a nasal cavity of a patient through nostrils, the nasal prongs comprising a thermal conductive surface; inserting an oral tube into oral cavity of a patient through mouth, the oral tube is a hollow member comprising a proximal end, a distal end, and an outward air driving fan positioned at the distal end; inserting temperature sensors into patient's ears; delivering a cooled air flow onto a surface of the patient's nasal cavity through the cold surface of the nasal prongs for a period of between minutes to hours; wherein the cooled airflow is circulated within the nasal and oral cavities and wherein the substantially cold air exchange heat with the surface of the nasal cavity to reduce the cerebral temperature of the patient to a protective temperature range; measuring the patient's brain temperature; and adjusting delivery of the cold airflow in response to the patient's brain temperature measurement results.

10. The method of claim 9, comprising of adjusting the temperature of the cooling element and the speed of the air driving fan.

11. The method of claim 9, further comprising stopping and resuming the step of delivering the cold air onto the surface of the patient's nasal cavity, passing the cold surface of nasal prongs for the period of time from between minutes to hours to prevent rewarming of the patient's brain.

12. The method of claim 9, wherein measuring the patient's brain temperature comprises measuring the patient's cerebral temperature through temperature sensors in the ears.

13. The method of claim 9, wherein the step of measuring the patient's brain temperature further comprises continuously monitoring the patient's brain temperature through ear temperature sensors.

14. The method of claim 9, further comprising the step of setting a target temperature range for the brain cooling, wherein the step of delivering the cold airflow further comprises delivering the cold airflow onto the surface of the patient's nasal cavity until the brain temperature reaches the target temperature range.

15. The method of claim 14, further comprising automatically stopping, and resuming steps of delivering the cold airflow onto the surface of the patient's nasal cavity when the patient's brain temperature reaches the target temperature range, and when the patient's brain temperature rises more than the preselected tolerance above the target temperature range.

16. The method of claim 14, wherein the target brain temperature is set by an operator within a certain temperature range.

17. A brain cooling air channel comprising: air cooling prongs at the nostrils forming the intake or entrance of the air channel; cooling prongs providing cold air stream flowing into nasal cavity and exchange heat with the surface of nasal cavity to remove heat from the brain to reduce cerebral temperature; an air outlet tube at patient's mouth comprising air sealing to form the exit of the air channel; an air outlet tube comprising an outward air driving fan at the exit of the air outlet tube to drive the airflow out of the air channel; an outward air driving fan at the exit of the air channel driving the airflow inside the air channel.

18. The air driving fan of claim 17 drives the airflow passing through the heat sink of cooling element to dissipate waste heat from the solid state thermal electric element or other cooling elements.

19. A device implementing the method of claim 17, comprising supporting hardware components: a controllable cooling source comprising solid state thermal electric cooling element or other alternative cooling elements to cool the airflow to a desired temperature range; an airflow driver comprising an air driving element to drive airflow flowing from nostrils through nasal cavity and then oral cavity to mouth and exit to the environment through a heat sink, dissipating waste heat generated by the cooling element; a controllable voltage source comprising Buck converters to generate required voltage source powering the thermal electric cooling element to different cooling temperatures, and to generate required voltage source driving the air driving element to operate at different speed; a power source providing power to the device to operate independently without external power source for a certain length of time; a patient brain temperature measurement element comprising temperature sensors measuring patient's brain temperature in real time; a control element comprising a microcontroller receiving device operation parameters set by operators to control the operation of said brain cooling device; a set of memory comprising non-volatile memory storing operation parameters even after the battery is out, so operation parameters set will remain effective until modified by operators.

20. The power source of claim 19 may comprise of rechargeable battery or other portable power sources to maintain portability of the device.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0033] FIG. 1 illustrates the device having thermal conductive nasal prongs, and a mouth tube to be inserted into the nasal and oral cavities of a patient.

[0034] FIG. 2 illustrates the function block diagrams of the device as well as its components and parts.

[0035] FIG. 3 is a flowchart illustrating device set-up process and an exemplary method for maintaining a patient's cerebral temperature within a target temperature range, and a method to monitor battery voltage.

DETAILED DESCRIPTION

[0036] The detailed embodiments of the present invention are disclosed herein. The invention is not limited to the disclosed description, which is merely exemplary of the embodiments of the invention. The invention can be embodied in different forms without departure from the principle introduced here.

[0037] In accordance with the present invention, and with reference to FIG. 1-3, a cooling device for noninvasive nasopharyngeal cerebral cooling is disclosed. One form of the invention is illustrated and is indicated in general by numeral 101. The device 101 has a cooling source composed of solid-state coolers 206, and a temperature-sensing accessory 103. These elements are coupled with nasal prongs 102, and oral tube 104 for circulation of air through the nasal and oral cavities, particularly, the upper nasal cavity. A control sub-system controls the cooling elements and monitors cerebral temperatures. As such, the microcontroller 210 receives input data from the temperature sensor 103 to regulate the speed of the cooling derive 206 and air driving fan 208 by controlling their operation voltages through buck converter 204 throughout operations.

[0038] Device 101 is illustrated in FIG. 1. with a patient 100 drawn for reference. As part of the set-up process, the operator inserts nasal prongs 102 into the patient's nasal cavity, oral tube 104 into the mouth, and ear temperature sensors 103 into the ears. Nasal prongs 102 have a smooth surface to avoid damaging tissues inside the nasal cavity. It is sized to enter the nasal cavity, and it will not obstruct air entry into the nasal cavity. The prongs are illustrated vertically, though it can be tilted. It will be recognized that the length and shape of the nasal prongs may vary to maximize heat exchange efficiency and avoid patient nasal tissue damage. Mouth tube 104 is sized to enter the oral cavity. The outlet of fan 208 is positioned in the device 101 at the distal end of the oral tube 104, so outward air-driving fan 208 can suck environmental air to pass the nasal and oral cavities, and into the tube. Incoming air from the nostrils is cooled after it passes the cold nasal prongs. When the cooled air travels towards the entrance of the oral tube, it fills the nasal cavity and cools the upper nasal cavity, in turn, lowering cerebral temperatures.

[0039] Nasal prongs 102 may be made from any nonreactive, and thermal conductive material, so cold from the Peltier cooler can quickly and efficiently transfer onto the entire prong. Nasal prongs comprising of unreactive materials will not have any deleterious side effects to patients. Examples of such materials include, but are not limited to stainless steel, gold plated copper, or silver, etc.

[0040] The oral portion includes a mouth plug 105 at the end of the oral tube. The plug may be placed into the patient's mouth to cover the entrance to the oral cavity and make it air seal. It is important that mouth plug 105 covers the mouth, so environmental air can only enter the patient's nasal cavity through the nostrils. Alternatively, the mouth plug may be situated outside the patient's mouth, provided it covers the entire mouth and seals the air.

[0041] The device 101 also has temperature sensors 103 with one temperature sensor in each ear. When the temperature sensor is inserted into the ear, it will measure cerebral temperatures in real-time and send the measurement results to the microcontroller, so the microcontroller can determine how to regulate cooling device temperatures and fan speed accordingly.

[0042] Attached to the nasal prongs is a solid-state thermo-electric Peltier device 206 having fast response time, small size, and high heat pumping capability. These many advantages make Peltier coolers a desirable component for use in conjunction with the disclosed brain-cooling device. The Peltier cooler and nasal prongs have an engagement surface, where the nasal prongs and the cold side of Peltier cooler contact, so nasal prongs become cold. Electrical Peltier cooling can be adjusted to any temperature between 2 C. to the ambient temperature. In turn, the nasal prongs may be cooled to those temperatures too. A heat sink is mounted on the hot side of Peltier device 206. The air-driving fan 208 drives the outward air to pass through the heat sink to dissipate the waste heat to the environment.

[0043] Alternative to a heat sink, the waste heat may be removed via circulating cooling fluid, any other method of absorbing heat, or dissipating heat for the purpose of conveying waste heat away from the hot side of the Peltier cooler. The air driving fan blows the air streams through the heat sink of the thermal electric cooling element so the waste heat generated by the air driving elements and thermal electric elements will be expelled along with the air flow into the environment without heating up the nasal and oral cavities.

[0044] Battery 202 provides energy for the cooler, air driving fan, temperature sensors and other control elements used in this invention. Any batteries that pose no hazardous, caustic, combustible threat, nor cause undo risks if casings are ruptured or damaged are suitable for this device. Alternatively, the device can run on any other power source used in accordance with the invention, for example a solar cell panel that can provide power at remote locations.

[0045] After battery drain, external power 200 is connected to this device to recharge the battery 202. The battery charging control 212 includes a power converter that automatically converting input voltages to a suitable DC level for battery recharging. The microcontroller 210 in the control sub-system controls battery charging process from start to end.

[0046] In another object of the invention, a smart control sub-system regulates nasal prong temperature, fan speed, and in turn, patient brain temperature with the minimum energy consumption. During operation, the microcontroller 210 inside the device receives real-time temperature data measured by the temperature sensors 103 and responds accordingly. The microcontroller adjusts fan 208 speed from low to high settings and regulates nasal prong temperatures by controlling the input voltage to the Peltier cooler. Controlling Buck Converter 204 outputs allows the microcontroller to effectively switch between the above-mentioned settings to maximize efficiency, and prolong battery life. Alternatively, buck converter 204 may be replaced with another means of regulating cooler temperature and fan speed.

[0047] The functions of the microcontroller are herein detailed. The microcontroller records commands from the user after he or she selects a temperature range via user interface panel 214. The microcontroller receives temperature measurement results from the temperature sensors 103 and adjusts buck converter outputs to regulate fan speed and Peltier cooler temperature accordingly. The microcontroller is also capable of supportive functions 212 including battery overheat prevention, battery charge or discharge control, as well as DC-DC converter operations used in battery recharging. To ensure safety of batteries, the microcontroller monitors battery pack output current and temperatures continuously. Any abnormal output current increase and/or battery temperature rise will cause the microcontroller to cut off the batteries completely to prevent battery overheat. The microcontroller is programmable, hence can be programmed to perform additional functions not disclosed here.

[0048] As depicted in the flowchart illustrated in FIG. 3, a microcontroller regulates the device cooler temperatures, and battery status when used in conjunction with temperature sensors and user-interface. This control sub-system may include continuous time interrupts at pre-determined intervals to automatically regulate internal functions. For maintaining cerebral temperatures, the device analyzes real-time brain temperature at every interval and determines how to regulate voltage to the cooler and fan until brain temperature reaches the target temperature, and then maintain the temperature range until the patient is transferred to hospital where systematic brain cooling method will be used.

[0049] As shown in FIG. 3, in operation initialization step 1000, the device starts and calibrates temperature sensors. At step 1002, the microcontroller control panel displays a message to prompt the user to set brain cooling parameters, which may include a target cerebral temperature, and/or specific cooling patterns to accommodate unique patient cases. For example, as depicted in step 1008, the default airflow setting can be the lowest or the highest speed, but it can change as the operator sees fit. After the operator inserts the nasal prongs into the patient's nose, oral tube into patient's mouth and seal it, and plugs temperature sensors into the patient's ear at step 1004, the device is ready for operation. At step 1006, the device prompts the operator to push the start button to initiate brain cooling. At step 1008, the device is turned on and begins to circulate the coldest air at the highest speed, while simultaneously starting two interrupt timers. The following steps are in infinity loops.

[0050] Timer 1 interrupt service subroutine step 1010 starts the closed-loop control sub-system, which operates at every one-second interval. Every second, Timer 1 interrupts the microcontroller function and analyze the temperature sensor measurement against the target temperature. Then, the device calculates the present brain cooling speed. At step 1012, the microcontroller analyzes the difference between present and the target brain temperatures to calculate the optimal brain cooling speed to reach/maintain the desired temperature. The microcontroller determines whether the present cooling speed is right, or too high, or too low. If the temperature reading value is lower than the target temperature, the microcontroller determines the present cooling speed is too high and proceeds to step 1014. At step 1014, the microcontroller decreases voltages to the fan and cooling device to lower fan speed and increase cooler temperature. Alternatively, the microcontroller may turn off voltage to the fan and Peltier cooler entirely until the next interrupt. Conversely, at step 1012, if the brain temperature is higher than the target temperature, then the cooling speed is too low and the device proceeds to step 1016. If the fan speed and cooler setting is not at the highest/coldest, the microcontroller will increase the voltage to these elements, as depicted at step 1018. If the fan speed and cooler temperature is already at their highest settings, the microcontroller will maintain the highest setting and revert back to step 1020, until temperature is again measured and found to be at the target temperature. At step 1012, the microcontroller may determine that the cooling speed is correct and the voltages to the cooling and fan elements stay the same until the next time interrupt at step 1020.

[0051] As mentioned above, the control sub-system has a supportive function of monitoring battery voltage. The microcontroller also provides means of informing the operator when battery voltage is low. This is shown by the sequence following step 1022. Timer two interrupts the microcontroller every minute. At step 1022, the microcontroller reads the battery voltage and determines if the battery has less than 5 minutes of operation time remaining. If the device has more than 5 minutes of battery capacitance remaining, it returns to normal operation from the interrupt. If the battery has less than 5 minutes of operation time remaining 1024, the microcontroller will proceed to step 1026 and prompt the user to plug in the power adapter to recharge the battery, and display the operation time remaining before the device returns from interrupt.

[0052] In summary, the embodiments of the device disclosed herein may be used for a plurality of potential uses and implementation, among which mitigation of brain damage after cardiac arrest and traumatic brain injury in out-of-hospital settings is the function discussed above. The energy efficient aspects of the invention allow the overall device to be small in size, light in weight, and easy to use. These advantages are especially important in emergency operational settings. In combination with a smart feedback control sub-system, the device is reliable and can be used without highly specialized operators.