Compounds and compositions for the inhibition of NAMPT

Abstract

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: ##STR00001##

Claims

1. A compound of formula IIB or a pharmaceutically acceptable salt thereof: wherein: ##STR01632## R is bicyclic heteroaryl comprising 1, 2, 3, or 4 heteroatom(s) independently selected from N, S, and O, wherein said heteroaryl may be substituted by one or more substituents selected from the group consisting of amino, oxo, and halo; and wherein said heteroaryl can comprise one or more N-oxide(s) formed with a N atom member of said heteroaryl; R.sup.1 is cycloalkyl, wherein: (i) said cycloalkyl is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents which can be the same or different and are independently selected from the group consisting of: deuterium, halo, hydroxy, hydroxyalkyl, cyano, —(CH.sub.2).sub.mNR.sup.aR.sup.b, oxo, alkyl, cyanoalkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl-, alkenyl, alkynyl, alkynylalkoxy, —CONH.sub.2, —S-alkyl, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(cycloalkyl), —C(O)NH(aryl), —C(O)N(aryl).sub.2, arylalkyl-, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S(O).sub.2-aryl, —S(O).sub.2—CH.sub.zF.sub.3-z, —C(O)alkyl, —N(R.sup.5)—C(O)-alkyl, —N(R.sup.5)—C(O)-aryl, —S(O).sub.2NH.sub.2, —S(O).sub.2NH(alkyl), —S(O).sub.2N(alkyl).sub.2, —N(H)S(O).sub.2(alkyl), and methylenedioxy, wherein each of said cycloalkyl, heterocycloalkyl, aryl, or heteroaryl may be substituted by one or more halo, cyano, alkyl, and alkoxy; and (ii) said cycloalkyl may optionally additionally be fused with independently selected heterocycloalkyl or cycloalkyl to form a bicyclic or tricyclic group that may be substituted by one or more halo, cyano, alkyl, and alkoxy; R.sup.2 and R.sup.3 are independently selected from the group consisting of H and deuterium; R.sup.5 is H, alkyl, or arylalkyl-; R.sup.a and R.sup.b are independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl, and haloalkyl; m is 0, 1, 2, 3, 4, 5, or 6; and z is 0, 1, or 2.

2. The compound of claim 1, wherein R is selected from 9- to 10-membered bicyclic heteroaryl groups containing 1, 2, 3, or 4 heteroatoms independently selected from N, S, and O.

3. The compound of claim 1, wherein R is selected from the group consisting of: benzothiazole, dihydronaphthyridine, dihydropyridopyrimidine, dihydropyrrolopyridine, furopyridine, imidazopyrazine, imidazopyrazole, imidazopyridine, imidazopyrimidine, indazole, indole, isoquinoline, naphthyridine, pyrazolopyridine, pyrrolopyridine, tetrazolopyridine, tetrahydroimidazopyridine, tetrahydropyrazolopyridine, thiazolopyridine, and thienopyridine.

4. The compound of claim 1, wherein R is selected from the group consisting of: 1H-pyrazolo[3,4-b]pyridine; 1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine; 7,8-dihydro-5H-pyrido[4,3-d]pyrimidine; 5,7-dihydro-pyrrolo[3,4-b]pyridine; 7,8-dihydro-5H-[1,6]naphthyridine; 1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine; 1,8a-dihydroimidazo[1,2-a]pyridine; thieno[3,2-c]pyridine; 1H-imidazo[1,2-b]pyrazole; furo[2,3-c]pyridine; 1H-pyrrolo[3,2-c]pyridine; thieno[2,3-b]pyridine; imidazo[1,2-a]pyrimidine; furo[2,3-c]pyridine; isoquinoline; 1H-indazole; imidazo[1,2-a]pyridine; thieno[2,3-c]pyridine; furo[2,3-c]pyridine; 1H-pyrrolo[2,3-c]pyridine; imidazo[1,2-a]pyrazine; 1,3-benzothiazole; benzo[d]thiazole; 1H-pyrrolo[2,3-b]pyridine; [1,3]thiazolo[5,4-c]pyridine; [1,2,3,4]tetrazolo[1,5-a]pyridine; 1,5-naphthyridine; 1H-indole; 1H-imidazo[4,5-c]pyridine; and 1,6-naphthyridine.

5. The compound of claim 1, wherein R is substituted at a position adjacent to a nitrogen atom on its cycle.

6. The compound of claim 1, wherein R.sup.1 is unsubstituted or substituted C.sub.3-C.sub.10 cycloalkyl.

7. The compound of claim 6, wherein R.sup.1 is cyclohexyl.

8. The compound of claim 1, wherein R.sup.1 is unsubstituted cycloalkyl or cycloalkyl substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of: halo, hydroxy, hydroxyalkyl, cyano, alkyl, alkynyl, alkynylalkoxy, alkoxyalkyl, alkoxy, haloalkyl, haloalkoxy, —C(O)NH(alkyl), —C(O)NH(cycloalkyl), —C(O)N(alkyl).sub.2, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy-, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S-alkyl, —C(O)alkyl, —S(O.sub.2)NH.sub.2, —S(O.sub.2)NH(alkyl), —S(O.sub.2)N(alkyl).sub.2, and —N(H)(SO.sub.2)(alkyl), wherein each of said cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be substituted by one or more halo, cyano, alkyl or alkoxy.

9. The compound of claim 1, wherein the compound is N-{[4-(cyclohexanesulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, or a pharmaceutically acceptable salt thereof.

10. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

11. A pharmaceutical composition comprising a compound of claim 9, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

Description

DESCRIPTION OF THE PREFERRED EMBODIMENTS

(1) An aspect of the present invention concerns compounds disclosed herein.

(2) An aspect of the present invention concerns compounds which are or can be inhibitors of the formation of nicotinamide phosphoribosyltransferase.

(3) An aspect of the present invention concerns the use of an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment, prevention, inhibition or elimination of tumors.

(4) An aspect of the present invention concerns the use of an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment, prevention, inhibition or elimination of cancer.

(5) An aspect of the present invention concerns the use of an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment, prevention, inhibition or elimination of cancer, where the cancer is selected from leukemia, lymphoma, ovarian cancer, breast cancer, uterine cancer, colon cancer, cervical cancer, lung cancer, prostate cancer, skin cancer, CNS cancer, bladder cancer, pancreatic cancer and Hodgkin's disease.

(6) The present invention also describes one or more methods of synthesizing the compounds of the present invention.

(7) The invention also describes one or more uses of the compounds of the present invention.

(8) The invention also describes one or more uses of the compounds of the present invention with an adjunctive agent such as use with TNF, GCSF, or other chemotherapeutic agents The invention also describes one or more uses of the pharmaceutical compositions of the present invention.

(9) An aspect of the present invention concerns the use as an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment of inflammatory diseases.

(10) An aspect of the present invention concerns the use as an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment of inflammatory diseases, such as Irritable Bowel Syndrome or Inflammatory Bowel Disease.

(11) An aspect of the present invention concerns the use as an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment of disease of the bone such as osteoporosis.

(12) An aspect of the present invention concerns the use as an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment of disease of the cardiovascular system, such as atherosclerosis.

(13) An aspect of the present invention concerns the use as an inhibitor of the formation of nicotinamide phosphoribosyltransferase for the preparation of a medicament used in the treatment of disease or a condition caused by an elevated level of NAMPT.

(14) Such disease or condition is one or more selected from the group consisting of cancer, ovarian cancer, breast cancer, uterine cancer, colon cancer, cervical cancer, lung cancer, prostate cancer, skin cancer, bladder cancer, pancreatic cancer, leukemia, lymphoma, Hodgkin's disease, viral infections, Human Immunodeficiency Virus, hepatitis virus, herpes virus, herpes simplex, inflammatory disorders, irritable bowel syndrome, inflammatory bowel disease, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, osteoarthritis, osteoporosis, dermatitis, atoptic dermatitis, psoriasis, systemic lupus erythematosis, multiple sclerosis, psoriatic arthritis, ankylosing spodylitis, graft-versus-host disease, Alzheimer's disease, cerebrovascular accident, atherosclerosis, diabetes, glomerulonephiritis, metabolic syndrome, non-small cell lung cancer, small cell lung cancer, multiple myeloma, leukemias, lymphomas, squamous cell cancers, kidney cancer, uretral and bladder cancers, cancers of head and neck, cancers of the brain and central nervous system (CNS).

(15) The inventive compounds can be useful in the therapy of proliferative diseases such as, but not limited to cancer, autoimmune diseases, viral diseases, fungal diseases, neurological/neurodegenerative disorders, arthritis, inflammation, anti-proliferative (e.g., ocular retinopathy), neuronal, alopecia and cardiovascular disease.

(16) More specifically, the compounds can be useful in the treatment of a variety of cancers, including (but not limited to) the following: carcinoma, including that of the bladder, breast, colon, kidney, liver, lung, including small cell lung cancer, non-small cell lung cancer, head and neck, esophagus, gall bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, and skin, including squamous cell carcinoma; hematopoietic tumors of lymphoid lineage, including leukemia, acute lymphocytic leukemia, acute lymphoblastic leukemia, B-cell lymphoma, T-cell lymphoma, Hodgkins lymphoma, non-Hodgkins lymphoma, hairy cell lymphoma, mantle cell lymphoma, myeloma, and Burkett's lymphoma; hematopoietic tumors of myeloid lineage, including acute and chronic myelogenous leukemias, myelodysplastic syndrome and promyelocytic leukemia; tumors of mesenchymal origin, including fibrosarcoma and rhabdomyosarcoma; tumors of the central and peripheral nervous system, including astrocytoma, neuroblastoma, glioma and schwannomas; and other tumors, including melanoma, seminoma, teratocarcinoma, osteosarcoma, xenoderoma pigmentosum, keratoctanthoma, thyroid follicular cancer and Kaposi's sarcoma.

(17) The compounds of the invention may induce or inhibit apoptosis.

(18) The compounds of the invention may also be useful in the chemoprevention of cancer. Chemoprevention is defined as inhibiting the development of invasive cancer by either blocking the initiating mutagenic event or by blocking the progression of pre-malignant cells that have already suffered an insult or inhibiting tumor relapse.

(19) A further aspect of the invention is a method of inhibiting a NAMPT pathway in an animal, said method comprising administering to said animal a pharmaceutically acceptable amount of a compound of the invention to an animal in need thereof.

(20) A further aspect of the invention is a pharmaceutical formulation comprising a compound of the invention.

(21) Another embodiment of the invention comprises a pharmaceutical formulation of the invention, wherein the pharmaceutical formulation, upon administration to a human, results in a decrease in tumor burden.

(22) Still another embodiment of the invention is a pharmaceutical formulation, further comprising one or more of an antineoplastic agent, a chemotherapeutic agent, or an adjunctive chemotherapeutic agent.

(23) The pharmaceutical formulations of the invention may further comprise a therapeutic effective amount of an adjunctive chemotherapeutic agent.

(24) The adjunctive chemotherapeutic agent may be an agent which modifies blood cell growth and maturation. Non-limiting examples of adjunctive chemotherapeutic agent are filgrastim, pegfilgrastim and erythropoietin.

(25) The invention is also directed to a method of treating or preventing a disorder associated with excessive rate of growth of cells in a mammal comprising administering to the mammal an effective amount of the pharmaceutical formulation of the invention. Non-limiting examples of disorder include cancer or metastasis from malignant tumors.

(26) Another aspect of the invention is a method of inhibiting tumor cell growth and rate of division in a mammal with cancer, or other disorder associated with abnormally dividing cells comprising administering to the mammal an effective amount of the pharmaceutical formulation of this invention.

(27) Another embodiment of the invention is a method of treating bone pain due to excessive growth of a tumor or metastasis to bone in a mammal in need thereof comprising administering to the mammal an effective amount of the pharmaceutical formulation of this invention.

(28) Still another embodiment of the invention is a method for administering a NAMPT-inhibitor-containing compound to a mammal in need thereof comprising administering to the mammal the pharmaceutical formulation of the invention. In one embodiment, the mammal is a human.

(29) A further embodiment of the invention is a method of preparing a pharmaceutical formulation comprising mixing at least one pharmaceutically acceptable compound of the present invention, and, optionally, one or more pharmaceutically acceptable excipients or additives.

(30) The invention is also directed to methods of synthesizing compounds of the present invention.

Compounds of the Invention

(31) The invention is directed to compounds as described herein and pharmaceutically acceptable salts, solvates, esters, prodrugs or isomers thereof, and pharmaceutical compositions comprising one or more compounds as described herein and pharmaceutically acceptable salts or isomers thereof. The invention further relates to molecules which are useful in inhibiting the enzyme nicotinamide phosphoribosyltransferase (NAMPT) and pharmaceutically acceptable salts, solvates, esters, prodrugs or isomers thereof.

(32) An aspect of this invention is the provision of compounds, compositions, kits, and antidotes for the NAMPT pathway in mammals having a compound of the Formula I:

(33) ##STR00040## wherein R is an aryl, heteroaryl, C.sub.3-C.sub.8 cycloalkyl, C.sub.3-C.sub.8 cycloalkenyl, heterocycloalkyl, arylalkyl-, (heteroaryl)alkyl-, (C.sub.3-C.sub.8 cycloalkyl)alkyl-, (C.sub.3-C.sub.8 cycloalkenyl)alkyl-, (heterocycloalkyl)alkyl-, (aryloxy)alkyl-, (heteroaryloxy)alkyl-, (C.sub.3-C.sub.8 cycloalkyloxy)alkyl-, (C.sub.3-C.sub.8 cycloalkenyloxy)alkyl- or (heterocycloalkyloxy)alkyl-, wherein the heteroatom of each of said heteroaryl and heterocycloalkyl numbers 1, 2 or 3, and is independently selected from N, S or O, further wherein each of said aryl, heteroaryl and heterocycloalkyl may independently be either substituted or fused with an aryl or heteroaryl, still further wherein any of said aryl, heteroaryl and heterocycloalkyl is either unsubstituted or optionally independently substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl-, (amino)alkoxy-, —CONH.sub.2, —C(O)NH(alkyl), —C(O)N(alky).sub.2, —C(O)NH(aryl), —C(O)N(aryl).sub.2, —CH.sub.zF.sub.3-z, —OCH.sub.zF.sub.3-z, -alkyl, -alkenyl, -alkynyl, -alkoxy, hydroxyl, alkyl hydroxy, hydroxyl, alkyl hydroxy, or (alkoxyalkyl) amino-, —N(R.sup.3)—C(O)-alkyl, —N(R.sup.3)—C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and heteroaryl, with the proviso that no two adjacent ring heteroatoms are both S or both O; Ar is aryl, heteroaryl, heterocycloalkyl or C.sub.3 to C.sub.8 cycloalkyl, with each of said aryl, heteroaryl, heterocycloalkyl and cycloalkyl being either unsubstituted or optionally independently substituted with 1, 2, 3 or 4 substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl-, (amino)alkoxy-, —CONH.sub.2, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(aryl), —C(O)N(aryl).sub.2, —CH.sub.zF.sub.3-z, —OCH.sub.zF.sub.3-z, -alkyl, -alkenyl, -alkynyl,-alkoxy, hydroxyl, -alkyl hydroxyl, aryloxy-, (alkoxyalkyl)amino-, —N(R.sup.3)—C(O)-alkyl, —N(R.sup.3)—C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and -heteroaryl; R.sup.4 is cycloalkyl, —CH.sub.zF.sub.3-z, aryl, heterocycloalkyl, heteroaryl, alkyl, -alkenyl, -alkynyl, (aryl)alkyl-, (heteroaryl)alkyl- or (heterocycloalkyl)alkyl-, or

(34) ##STR00041##
wherein each of said cycloalkyl, aryl, heterocycloalkyl, heteroaryl and alkyl is either unsubstituted or optionally substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl-, (amino)alkoxy-, —CONH.sub.2, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(aryl), —C(O)N(aryl).sub.2, —CH.sub.zF.sub.3-z, —OCH.sub.zF.sub.3-z, -alkyl, alkoxy-, -alkenyl, -alkynyl, aryloxy-, (alkoxyalkyl)amino-, -cycloalkyl, -heterocycloalkyl, (heterocycloalkyl)alkyl-, -aryl, (aryl)alkyl-, -heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S(O).sub.2-aryl, —S(O).sub.2—CF.sub.3, —C(O)N(alkyl).sub.2, —C(O)alkyl, —N(R.sup.3)—C(O)-alkyl, —N(R.sup.3)—C(O)-aryl, —S(O.sub.2)NH.sub.2, —S(O.sub.2)NH(alkyl), —S(O.sub.2)N(alkyl).sub.2, —N(H)S(O.sub.2)(alkyl), —C(O)N(H)(alkyl), and methylenedioxy, (ii) further wherein each of said cycloalkyl, aryl, heterocycloalkyl, and heteroaryl may optionally additionally be fused with independently selected aryl, heteroaryl, heterocycloalkyl or cycloalkyl; R.sup.3 is H, alkyl or arylalkyl-; X is S, S(O), S(O).sub.2, O or C(O); n is 1, 2, 3 or 4; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0, 1 or 2; and z is 0, 1 or 2; and pharmaceutically acceptable salts, solates, esters, prodrugs and isomers thereof.

(35) In the compounds of Formula I, the various moieties are independently selected.

(36) The following embodiments are directed to Formula I, as applicable. For any moieties that are not specifically defined, the previous definitions control. Further, the moieties aryl, heteroaryl, and heterocycloalkyl in these embodiments can be independently unsubstituted or optionally substituted or optionally fused as described earlier. Any one or more of the embodiments relating to Formula I below can be combined with one or more other embodiments of Formula I.

(37) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is aryl, and n, m, q, t, z, Ar, X, R.sup.4 and R.sup.3 are as defined.

(38) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is heteroaryl, and n, m, q, t, z, Ar, X, R.sup.4 and R.sup.3 are as defined.

(39) An embodiment of the invention is the provision of a compound of Formula I where the various moieties are independently selected, Ar is aryl, and R, n, m, q, t, z, X, R.sup.4 and R.sup.3 are as defined.

(40) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar is heteroaryl, and R, n, m, q, t, z, X, R.sup.4 and R.sup.3 are as defined.

(41) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and R.sup.3 are as defined and X is S.

(42) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and R.sup.3 are as defined and X is S(O).

(43) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and R.sup.3 are as defined and X is S(O.sub.2).

(44) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and R.sup.3 are as defined and X is O.

(45) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and R.sup.3 are as defined and X is C(O).

(46) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and R.sup.3 are as defined and X is C(O).

(47) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and X are as defined and R.sup.3 is H.

(48) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and X are as defined and R.sup.3 is alkyl.

(49) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.4 and X are as defined and R.sup.3 is arylalkyl.

(50) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.3 and X are as defined and R.sup.4 is aryl.

(51) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.3 and X are as defined and R.sup.4 is heteroaryl.

(52) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, Ar, R, n, m, q, t, z, R.sup.3 and X are as defined and R.sup.4 is heterocycloalkyl.

(53) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is aryl, R.sup.4 is heteroaryl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(54) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is aryl, R.sup.4 is aryl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(55) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is heteroaryl, R.sup.4 is heteroaryl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(56) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is heteroaryl, R.sup.4 is aryl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(57) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is phenyl, R.sup.1 is heteroaryl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(58) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is phenyl, R.sup.4 is aryl, and n, m, q, t, R.sup.1, R.sup.3 z, and Ar are as defined.

(59) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is heteroaryl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(60) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrrolopyridinyl, R.sup.4 is phenyl, and n, m, q, t, Ar, z, R.sup.3 and X are as defined.

(61) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl, R.sup.4 is phenyl, and n, m, q, t, Ar, z, R.sup.3 and X are as defined.

(62) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl (substituted with pyridinyl), R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(63) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(64) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl (substituted with pyridinyl), R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(65) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is imidazolyl, R.sup.4 is phenyl, and n, m, q, t, Ar, z, R.sup.3 and X are as defined.

(66) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is triazolopyridinyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(67) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is naphthyridinyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(68) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is tetrazolopyridinyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(69) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is isoquinolinyl, R.sup.4 is phenyl, and n, m, q, t, Ar, R.sup.3 z, and X are as defined.

(70) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is quinolinyl, R.sup.4 is phenyl, and n, m, q, t, Ar, z, R.sup.3 and X are as defined.

(71) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is imidazopyrazinyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(72) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is quinazolinyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(73) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is benzothiazolyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(74) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is thienopyridinyl, R.sup.4 is phenyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(75) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrrolopyridinyl, R.sup.4 is thiophenyl, and n, m, q, z, t, Ar, R.sup.3 and X are as defined.

(76) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl, R.sup.4 is naphthalinyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(77) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl (substituted with pyridinyl), R.sup.4 is quinolinyl, and n, m, q, z, t, Ar, R.sup.3 and X are as defined.

(78) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl, R.sup.4 is isoquinolinyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(79) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl (substituted with pyridinyl), R.sup.4 is benzodioxinyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(80) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is imidazolyl, R.sup.4 is phenoxathiinyl, and n, m, q, t, z, Ar, R.sup.3 and X are as defined.

(81) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrrolopyridinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(82) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(83) An embodiment of the invention is the provision of a compound of Formula I d, where the various moieties are independently selected, R is oxadiazolyl (substituted with pyridinyl), R.sup.4 is phenyl, Ar is phenyl, and n, m, z, q, t, R.sup.3 and X are as defined.

(84) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(85) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl (substituted with pyridinyl), R.sup.4 is phenyl, Ar is phenyl, and n, m, q, z, t, R.sup.3 and X are as defined.

(86) An embodiment of the invention is the provision of a compound, where the various moieties are independently selected, R is imidazolyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(87) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is triazolopyridinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(88) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is naphthyridinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(89) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is tetrazolopyridinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(90) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is isoquinolinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(91) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is quinolinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(92) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is imidazopyrazinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(93) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is quinazolinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(94) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is benzothiazolyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(95) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is thienopyridinyl, R.sup.4 is phenyl, Ar is phenyl, and n, m, q, t, z, R.sup.3 and X are as defined.

(96) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrrolopyridinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(97) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(98) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is oxadiazolyl (substituted with pyridinyl), R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(99) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is pyrazolyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(100) An embodiment of the invention is the provision of a compound of Formula I where the various moieties are independently selected, R is pyrazolyl (substituted with pyridinyl), R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(101) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is imidazolyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(102) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is triazolopyridinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(103) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is naphthyridinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(104) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is tetrazolopyridinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(105) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is isoquinolinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(106) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is quinolinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(107) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is imidazopyrazinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(108) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is quinazolinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(109) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is benzothiazolyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(110) An embodiment of the invention is the provision of a compound of Formula I, where the various moieties are independently selected, R is thienopyridinyl, R.sup.4 is phenyl, Ar is phenyl, n is 1, m is 1, q is 0, t is 0, z is 0, R.sup.3 and X are as defined.

(111) Another aspect of the invention are the compounds of Formula I, where q=0, m=0, t=0, Ar=A, X=Q and R4 is

(112) ##STR00042##
and the formula is now Formula IB

(113) ##STR00043## wherein R and R.sup.3 are as defined in Formula I; R.sup.1 and R.sup.2 are the same or they are different, and are independently selected from H, a straight or branched C.sub.1 to C.sub.7 alkyl, straight or branched C.sub.1 to C.sub.7 alkoxy, straight or branched C.sub.1 to C.sub.4 hydroxyalkyl, aryl, heteroaryl, heterocycloalkyl and cycloalkyl, and wherein heteroatoms of said heteroaryl and heterocycloalkyl are independently selected from one or more N, O and S, with the proviso that no two adjacent ring heteroatoms are both S or both O, further wherein R.sup.1 and R.sup.2 can be either unsubstituted or optionally independently substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl-, (amino)alkoxy-, —CONH.sub.2, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(aryl), —C(O)N(aryl).sub.2, —CH.sub.zF.sub.3-z, —OCH.sub.zF.sub.3-z, -alkyl, -alkenyl, -alkynyl, hydroxyalkyl-, -alkoxy, hydroxyl, alkyl hydroxy, carboxy, (alkoxyalkyl) amino-, -alkylamine, aminocarbonyl-, —CHO, —N(R.sup.3)—C(O)-alkyl, —N(R.sup.3)—C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and heteroaryl; A is aryl, heteroaryl, heterocycloalkyl or C.sub.3 to C.sub.8 cycloalkyl, with each of said aryl, heteroaryl, heterocycloalkyl and cycloalkyl being either unsubstituted or optionally independently substituted with 1, 2, 3 or 4 substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl-, (amino)alkoxy-, —CONH.sub.2, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(aryl), —C(O)N(aryl).sub.2, —CH.sub.zF.sub.3-z, —OCH.sub.zF.sub.3-z, -alkyl, -alkenyl, -alkynyl,-alkoxy, hydroxyl, -alkyl hydroxyl, aryloxy-, (alkoxyalkyl)amino-, —N(R.sup.3)—C(O)-alkyl, —N(R.sup.3)—C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and -heteroaryl; Q is C(O), S(O), S(O).sub.2, —N(H)—C(O)—, —S(O.sub.2)—NH—, or —N(H)—S(O.sub.2)—; n is 0, 1, 2, 3 or 4; and z is 0, 1 or 2; and pharmaceutically acceptable salts, solvates, esters, prodrugs or isomers thereof.

(114) Another embodiment of Formula IB are compounds of Formula IC

(115) ##STR00044## wherein R, A, Q, R.sup.3, z and n are as defined in Formula B, and R.sup.1 and R.sup.2 are joined together to form, along with the N they are shown attached to in the formula, a C.sub.3-C.sub.8 heterocycloalkyl, a C.sub.3-C.sub.8 heterocycloalkenyl, a fused bicyclic heterocycloalkyl, a fused tricyclic heterocycloalkyl, spiroheterocycloalkyl, or a heterospiroheterocycloalkyl, wherein each of said heterocycloalkyl, heterocycloalkenyl, spiroheterocycloalkyl, and heterospiroheterocycloalkyl can optionally contain one or more heteroatoms in addition to the N atom they are shown attached to in the formula, said heteroatoms being selected from N, S and O, with the proviso that no two adjacent ring heteroatoms are both S or both O, further wherein each of said heterocycloalkyl and heterocycloalkenyl can be either unsubstituted or optionally independently substituted with one or more substituents which can be the same or different and are independently selected from the group consisting of deuterium, halo, cyano, amino, aminoalkyl-, (amino)alkoxy-, —CONH.sub.2, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(aryl), —C(O)N(aryl).sub.2, —CH.sub.zF.sub.3_.sub.z, —OCH.sub.zF.sub.3-z, -alkyl, -alkenyl, -alkynyl, hydroxyalkyl, -alkoxy, hydroxyl, -alkyl hydroxy, carboxy, (alkoxyalkyl) amino-, -alkylamine, aminocarbonyl-, —CHO, —N(R.sup.3)—C(O)-alkyl, —N(R.sup.3)—C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and heteroaryl;
and pharmaceutically acceptable salts thereof.

(116) In the compounds of Formulas IB and C the various moieties are independently selected.

(117) The following embodiments are directed to Formula IB and C, as applicable. For any moieties that are not specifically defined, the previous definitions control. Further, the moieties aryl, heteroaryl, heterocycloalkyl, cycloalkyl, cycloalkenyl and heterocycloalkenyl in these embodiments can be independently unsubstituted or optionally substituted or optionally fused as described earlier. Any one or more of the embodiments relating to Formula IB and IC below can be combined with one or more other embodiments for Formula IB and IC.

(118) An embodiment of the invention is the provision of a compound of Formulas IB and IC, where the various moieties are independently selected, R is aryl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(119) Another embodiment of the invention is the provision of a compound of Formulas IB and IC where the various moieties are independently selected, R is heteroaryl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(120) Another embodiment of the invention is the provision of a compound of Formulas IB and IC, the various moieties are independently selected, R is C.sub.3-C.sub.8 cycloalkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(121) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is C.sub.3-C.sub.8 cycloalkenyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(122) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is heterocycloalkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(123) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is arylalkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(124) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (heteroaryl)alkyl, and n, A, Q and R and Rare as defined.

(125) Another embodiment of the invention is the provision of a compound of Formula IB and IC where the various moieties are independently selected, R is (C.sub.3-C.sub.8 cycloalkyl)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(126) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (C.sub.3-C.sub.8 cycloalkenyl)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(127) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (heterocycloalkyl)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(128) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (aryloxy)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(129) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (heteroaryloxy)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(130) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (C.sub.3-C.sub.8 cycloalkyloxy)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(131) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R is (C.sub.3—C cycloalkenyloxy)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(132) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (heterocycloalkyloxy)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(133) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, n, Q and R.sup.1 and R.sup.2 are as defined and A is aryl.

(134) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R, n, Q and G are as defined and A is heteroaryl.

(135) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R, n, Q and R.sup.1 and R.sup.2 are as defined and A is heterocycloalkyl.

(136) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, n, Q and R.sup.1 and R.sup.2 are as defined and A is C.sub.3-C.sub.8 cycloalkyl.

(137) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, A, Q and R.sup.1 and R.sup.2 are as defined and n is 0.

(138) Another embodiment of the invention is the provision of a compound of Formula I B and IC, where the various moieties are independently selected, R, A, Q and R.sup.1 and R.sup.2 are as defined and n is 1.

(139) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, A, Q and R.sup.1 and R.sup.2 are as defined and n is 2.

(140) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R, A, Q and R.sup.1 and R.sup.2 are as defined and n is 3.

(141) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, A, Q and R.sup.1 and R.sup.2 are as defined and n is 4.

(142) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R, A, n and R.sup.1 and R.sup.2 are as defined and Q is C(O).

(143) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, A, n and R.sup.1 and R.sup.2 are as defined and Q is S(O).

(144) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, A, n and R.sup.1 and R.sup.2 are as defined and Q is S(O.sub.2).

(145) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R, A, n and R.sup.1 and R.sup.2 are as defined and Q is —N(H)—S(O.sub.2)—.

(146) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R, A, n and R.sup.1 and R.sup.2 are as defined and Q is —S(O.sub.2)—N(H)—.

(147) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, A, n and R.sup.1 and R.sup.2 are as defined and Q is —N(H)—C(O)—.

(148) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is phenyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(149) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is naphthyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(150) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is pyridyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(151) An embodiment of the invention is the provision of a compound, where Formulas B and IC the various moieties are independently selected, R is a pyrrolopyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(152) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a thienopyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(153) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is an indazolyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(154) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a pyrazolopyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(155) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is an imidazopyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(156) An embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R is an imidazopyrazolyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(157) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a tetrazolopyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(158) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a naphthyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(159) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a benzodiazolyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(160) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a benzothiazolyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(161) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a furopyridinyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(162) An embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is a (pyridinyloxy)methyl group, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(163) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (pyridinyl)alkyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(164) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (pyridinyl)ethyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(165) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R is (pyrrolopyridinyl)methyl, and n, A, Q and R.sup.1 and R.sup.2 are as defined.

(166) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, n, Q and R.sup.1 and R.sup.2 are as defined and A is phenyl.

(167) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, R, n, Q and R.sup.1 and R.sup.2 are as defined and A is piperidinyl.

(168) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, R, A, n, R.sup.2, and Q are as defined, and R.sup.1 is H.

(169) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R, A, n, R.sup.1, and Q are as defined, and —R.sup.2 is piperidinyl.

(170) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R, A, n, R.sup.1, and Q are as defined, and —R.sup.2 is quinolinyl.

(171) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R, A, n, R.sup.1, and Q are as defined, R.sup.1 is H and —R.sup.2 is morpholinyl.

(172) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R, A, n, R.sup.1, and Q are as defined, R.sup.1 is H and —R.sup.2 is piperidinyl.

(173) Another embodiment of the invention is the provision of a compound of Formula B, where the various moieties are independently selected, R, A, n, R.sup.1, and Q are as defined, RT is H and —R.sup.2 is quinolinyl.

(174) Another embodiment of the invention is the provision of a compound of Formula IB, where the various moieties are independently selected, R, A, n, R.sup.1, and Q are as defined, and —R.sup.2 is morpholinyl.

(175) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1, R.sup.2, and Q are as defined, both A and R are aryl.

(176) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1, R.sup.2, and Q are as defined, both A and R are heteroaryl.

(177) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1 R.sup.2, and Q are as defined, R is heteroaryl and A is aryl.

(178) Another embodiment of the invention is the provision of a compound of Formula B and IC, where the various moieties are independently selected, n, R.sup.1, R.sup.2, and Q are as defined, R is (heteroaryl)alkyl and A is aryl.

(179) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1, R.sup.2, and Q are as defined, R is (heteroaryloxy)alkyl and A is aryl.

(180) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R, R.sup.2, and Q are as defined, R is aryl and A is heteroaryl.

(181) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R, Rare as defined, both A and R are aryl and Q is S(O.sub.2).

(182) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1, R.sup.2 are as defined, both A and R are heteroaryl and Q is S(O.sub.2).

(183) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1, R.sup.2 are as defined, A is aryl, R is heteroaryl and Q is S(O.sub.2).

(184) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R.sup.1 R.sup.2 are as defined, A is aryl, R is (heteroaryl)alkyl and Q is S(O.sub.2).

(185) Another embodiment of the invention is the provision of a compound of Formula IB and IC, where the various moieties are independently selected, n, R, R.sup.2 are as defined, A is aryl, R is (heteroaryloxy)alkyl and Q is S(O.sub.2).

(186) Another aspect of the invention is compounds derived from Formula I where q=0, m=0 and t=0, whereby the formula becomes Formula II or pharmaceutically acceptable salts thereof:

(187) ##STR00045## wherein: R is heteroaryl comprising 1, 2, 3 or 4 heteroatom(s) independently selected from N, S or O, wherein said heteroaryl may be substituted by one or more substituents selected from the group consisting of amino, oxo, and halo; and wherein said heteroaryl can comprise one or more N-oxide(s) formed with a N atom member of said heteroaryl; Ar is aryl or heteroaryl comprising 1, 2, 3 or 4 heteroatom(s) independently selected from N, S or O; X is S(O).sub.2 or S═O; R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl; cycloalkyl; aryl; heterocycloalkyl; or heteroaryl; wherein: each of said cycloalkyl, aryl, or heteroaryl is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of: deuterium, halo, hydroxy, hydroxyalkyl, cyano, —(CH.sub.2).sub.mNR.sup.aR.sup.b, oxo, alkyl, cyanoalkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl-, alkenyl, alkynyl, alkynylalkoxy, —CONH.sub.2, —S-alkyl, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(cycloalkyl), —C(O)NH(aryl), —C(O)N(aryl).sub.2, arylalkyl-, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy-, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S(O).sub.2-aryl, —S(O).sub.2—CH.sub.zF.sub.3-z, —C(O)alkyl, —N(R.sup.5)—C(O)-alkyl, —N(R.sup.5)—C(O)-aryl, —S(O.sub.2)NH.sub.2, —S(O.sub.2)NH(alkyl), —S(O.sub.2)N(alkyl).sub.2, —N(H)(SO.sub.2)(alkyl), and methylenedioxy, wherein each of said cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be substituted by one or more halo, cyano, alkyl or alkoxy and; each of said cycloalkyl, heterocycloalkyl, aryl, or heteroaryl may optionally additionally be fused with independently selected aryl, heteroaryl, heterocycloalkyl or cycloalkyl to from a bicyclic or tricyclic group that may be substituted by one or more halo, cyano, alkyl or alkoxy; R.sup.2 and R.sup.3 can be independently selected from the group consisting of H and deuterium; R.sup.5 is H, alkyl or arylalkyl-; R.sup.a and R.sup.b are independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl and haloalkyl; m is 0, 1, 2, 3, 4, 5 or 6; and n is 0 or 1;

(188) An embodiment of Formula II of this invention is the provision of compounds compositions, kits and antidotes for the NAMPT pathway in mammals where X is S(O).sub.2 and n=1, the formula now becoming the Formula II A:

(189) ##STR00046## wherein: R is heteroaryl comprising 1, 2, 3 or 4 heteroatom(s) independently selected from N, S or O, wherein said heteroaryl may be substituted by one or more substituents selected from the group consisting of amino, oxo, and halo; and wherein said heteroaryl can comprise one or more N-oxide(s) formed with a N atom member of said heteroaryl; Ar is aryl or 5 or 6 membered heteroaryl comprising 1, 2, 3 or 4 heteroatom(s) independently selected from N, S or O; R.sup.1 is —NHR.sup.4 where R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl; cycloalkyl; aryl; or heteroaryl; wherein: each of said cycloalkyl, aryl, or heteroaryl is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of: deuterium, halo, hydroxy, hydroxyalkyl, cyano, —(CH.sub.2).sub.mNR.sup.aR.sup.b, oxo, alkyl, cyanoalkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl-, alkenyl, alkynyl, alkynylalkoxy, —CONH.sub.2, —S-alkyl, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(cycloalkyl), —C(O)NH(aryl), —C(O)N(aryl).sub.2, arylalkyl-, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy-, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S(O).sub.2-aryl, —S(O).sub.2—CH.sub.zF.sub.3-z, —C(O)alkyl, —N(R.sup.5)—C(O)-alkyl, —N(R.sup.5)—C(O)-aryl, —S(O.sub.2)NH.sub.2, —S(O.sub.2)NH(alkyl), —S(O.sub.2)N(alkyl).sub.2, —N(H)(SO.sub.2)(alkyl), and methylenedioxy, wherein each of said cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be substituted by one or more halo, cyano, alkyl or alkoxy and; each of said cycloalkyl, heterocycloalkyl, aryl, or heteroaryl may optionally additionally be fused with independently selected aryl, heteroaryl, heterocycloalkyl or cycloalkyl to from a bicyclic or tricyclic group that may be substituted by one or more halo, cyano, alkyl or alkoxy; R.sup.2 and R.sup.3 can be independently selected from the group consisting of H and deuterium; R.sup.5 is H, alkyl or arylalkyl-; R.sup.a and R.sup.b are independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl and haloalkyl; and m is 0, 1, 2, 3, 4, 5 or 6.

(190) In the compounds of Formulas II, and IIA, the various moieties are independently selected.

(191) The following embodiments are directed to Formulas II, and IIA as applicable. For any moieties that are not specifically defined, the previous definitions control. Further, the moieties aryl, heteroaryl, heterocycloalkyl, cycloalkyl, cycloalkenyl and heterocycloalkenyl in these embodiments can be independently unsubstituted or optionally substituted or optionally fused as described earlier. Any one or more of the embodiments relating to Formula II or IIA below can be combined with one or more other embodiments for Formula II or IIA.

(192) An embodiment of the invention is the provision of a compound of Formula II or II A where the various moieties are independently selected and Ar is aryl.

(193) An embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and Ar is phenyl.

(194) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and Ar has the formula of:

(195) ##STR00047##

(196) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and Ar is 5 or 6 membered heteroaryl.

(197) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and Ar is pyridine.

(198) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is a bicyclic heteroaryl.

(199) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O.

(200) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is selected from benzothiazole, dihydronaphthyridine, dihydropyridopyrimidine, dihydropyrrolopyridine, furopyridine, imidazopyrazine, imidazopyrazole imidazopyridine, imidazopyrimidine, indazole, indole, isoquinoline, naphthyridine, pyrazolopyridine, pyrrolopyridine, tetrazolopyridine, tetrahydroimidazopyridine, tetrahydropyrazolopyridine, thiazolopyridine and thienopyridine.

(201) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is selected from 1H-pyrazolo[3,4-b]pyridine; 1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine; 7,8-Dihydro-5H-pyrido[4,3-d]pyrimidine; 5,7-Dihydro-pyrrolo[3,4-b]pyridine; 7,8-Dihydro-5H-[1,6]naphthyridine; 1,4,6,7-Tetrahydro-imidazo[4,5-c]pyridine; 1,8a-dihydroimidazo[1,2-a]pyridine; thieno[3,2-c]pyridine; 1H-imidazo[1,2-b]pyrazole; 1H-pyrazolo[3,4-b]pyridine; furo[2,3-c]pyridine; 1H-pyrazolo[3,4-b]pyridine; 1H-pyrrolo[3,2-c]pyridine; thieno[2,3-b]pyridine; imidazo[1,2-a]pyrimidine; furo[2,3-c]pyridine; isoquinoline; 1H-indazole; imidazo[1,2-a]pyridine; thieno[2,3-c]pyridine; furo[2,3-c]pyridine; 1H-pyrrolo[2,3-c]pyridine; imidazo[1,2-a]pyrazine; 1,3-benzothiazole; benzo[d]thiazole; 1H-pyrrolo[2,3-b]pyridine; [1,3]thiazolo[5,4-c]pyridine; [1,2,3,4]tetrazolo[1,5-a]pyridine; 1,5-naphthyridine; 1H-indole; 1H-imidazo[4,5-c]pyridine; and 1,6-naphthyridine.

(202) Another embodiment of the invention is the provision of compounds of Formula II or IIA wherein R is selected from the group consisting of:

(203) ##STR00048##

(204) Another embodiment of the invention is the provision of a compound of Formula II or II A where the various moieties are independently selected, Ar is aryl and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O.

(205) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O.

(206) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl and R is selected from benzothiazole, dihydronaphthyridine, dihydropyridopyrimidine, dihydropyrrolopyridine, furopyridine, imidazopyrazine, imidazopyrazole imidazopyridine, imidazopyrimidine, indazole, indole, isoquinoline, naphthyridine, pyrazolopyridine, pyrrolopyridine, tetrazolopyridine, tetrahydroimidazopyridine, tetrahydropyrazolopyridine, thiazolopyridine and thienopyridine.

(207) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and Ar is 5 or 6 membered heteroaryl and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O.

(208) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is pyridine and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O.

(209) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is substituted at a position adjacent to a nitrogen atom on its cycle.

(210) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is aryl and R is substituted at a position adjacent to a nitrogen atom on its cycle.

(211) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl and R is substituted at a position adjacent to a nitrogen atom on its cycle.

(212) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is 5 or 6 membered heteroaryl and R is substituted at a position adjacent to a nitrogen atom on its cycle.

(213) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is pyridine and R is substituted at a position adjacent to a nitrogen atom on its cycle.

(214) Another embodiment of the invention is the provision of a compound of Formula II or II A where the various moieties are independently selected, R is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(215) Another embodiment of the invention is the provision of a compound of Formula III or IIIA where the various moieties are independently selected, Ar is aryl, R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(216) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl, R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(217) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is 5 or 6 membered heteroaryl, R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(218) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is pyridine, R is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(219) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O, Ar is phenyl and R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(220) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R is a 9 to 10 membered bicyclic heteroaryl containing 1, 2, 3, or 4 heteroatoms independently selected from N, S or O, Ar is pyridine and R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(221) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R, is unsubstituted or substituted C.sub.3-C.sub.10 cycloalkyl.

(222) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is aryl, and R.sup.1 is unsubstituted or substituted C.sub.3-C.sub.10 cycloalkyl.

(223) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl, and R is unsubstituted or substituted C.sub.3-C.sub.10 cycloalkyl.

(224) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is 5 or 6 membered heteroaryl, and R.sup.1 is unsubstituted or substituted C.sub.3-C.sub.10 cycloalkyl.

(225) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is pyridine, and R.sup.1 is unsubstituted or substituted C.sub.3-C.sub.10 cycloalkyl.

(226) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R.sup.1 is unsubstituted or substituted aryl.

(227) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl comprising 1, 2, 3, or 4 heteroatom(s) selected from N, S or O.

(228) Another embodiment of the invention is the provision of a compound of Formula II or II A where the various moieties are independently selected, Ar is aryl and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl comprising 1, 2, 3, or 4 heteroatom(s) selected from N, S or O.

(229) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl comprising 1, 2, 3, or 4 heteroatom(s) selected from N, S or O.

(230) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is 5 or 6 membered heteroaryl and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl comprising 1, 2, 3, or 4 heteroatom(s) selected from N, S or O.

(231) Another embodiment of the invention is the provision of a compound of Formula II or II A where the various moieties are independently selected, Ar is pyridine and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl comprising 1, 2, 3, or 4 heteroatom(s) selected from N, S or O.

(232) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl containing at least one N-heteroatom from which the heterocycloalkyl is attached to the rest of the compound of Formula II or IIA.

(233) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is aryl and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl containing at least one N-heteroatom from which the heterocycloalkyl is attached to the rest of the compound of Formula II or IIA.

(234) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is phenyl and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl containing at least one N-heteroatom from which the heterocycloalkyl is attached to the rest of the compound of Formula II or IIA.

(235) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is 5 or 6 membered heterocyclic aryl and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl containing at least one N-heteroatom from which the heterocycloalkyl is attached to the rest of the compound of Formula II or IIA.

(236) Another embodiment of the invention is the provision of a compound of Formula II or IIA where the various moieties are independently selected, Ar is pyridine and R.sup.1 is unsubstituted or substituted 5 to 11 membered monocyclic or bicyclic heterocycloalkyl containing at least one N-heteroatom from which the heterocycloalkyl is attached to the rest of the compound of Formula II or IIA.

(237) One embodiment of Formula IIA are compounds where Ar is phenyl and the formula becomes Formula IIB

(238) ##STR00049## wherein: R is bicyclic heteroaryl comprising 1, 2, 3 or 4 heteroatom(s) independently selected from N, S or O, wherein said heteroaryl may be substituted by one or more substituents selected from the group consisting of amino, oxo, and halo; and wherein said heteroaryl can comprise one or more N-oxide(s) formed with a N atom member of said heteroaryl; R.sup.1 is —NHR.sup.4 and R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl; cycloalkyl; aryl; or heteroaryl; wherein: each of said cycloalkyl, aryl, or heteroaryl is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of: deuterium, halo, hydroxy, hydroxyalkyl, cyano, —(CH.sub.2).sub.mNR.sup.aR.sup.b, oxo, alkyl, cyanoalkyl, haloalkyl, alkoxy, haloalkoxy, alkoxyalkyl-, alkenyl, alkynyl, alkynylalkoxy, —CONH.sub.2, —S-alkyl, —C(O)NH(alkyl), —C(O)N(alkyl).sub.2, —C(O)NH(cycloalkyl), —C(O)NH(aryl), —C(O)N(aryl).sub.2, arylalkyl-, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy-, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S(O).sub.2-aryl, —S(O).sub.2—CH.sub.zF.sub.3-z, —C(O)alkyl, —N(R.sup.5)—C(O)-alkyl, —N(R.sup.5)—C(O)-aryl, —S(O.sub.2)NH.sub.2, —S(O.sub.2)NH(alkyl), —S(O.sub.2)N(alkyl).sub.2, —N(H)(SO.sub.2)(alkyl), and methylenedioxy, wherein each of said cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be substituted by one or more halo, cyano, alkyl or alkoxy and; each of said cycloalkyl, heterocycloalkyl, aryl, or heteroaryl may optionally additionally be fused with independently selected aryl, heteroaryl, heterocycloalkyl or cycloalkyl to from a bicyclic or tricyclic group that may be substituted by one or more halo, cyano, alkyl or alkoxy; R.sup.2 and R.sup.3 can be independently selected from the group consisting of H and deuterium; R.sup.5 is H, alkyl or arylalkyl-; R.sup.a and R.sup.b are independently selected from the group consisting of H, alkyl, alkoxy, alkoxyalkyl and haloalkyl; m is 0, 1, 2, 3, 4, 5 or 6; z is 0, 1 or 2.

(239) An embodiment of the invention are compounds of Formula II B where R is selected from 9 to 10 membered bicyclic heteroaryl groups containing 1,2,3 or 4 heteroatoms independently selected from N, S, and O.

(240) Another embodiment of the invention are compounds of Formula IIB, where R is selected from: benzothiazole, dihydronaphthyridine, dihydropyridopyrimidine, dihydropyrrolopyridine, furopyridine, imidazopyrazine, imidazopyrazole imidazopyridine, imidazopyrimidine, indazole, indole, isoquinoline, naphthyridine, pyrazolopyridine, pyrrolopyridine, tetrazolopyridine, tetrahydroimidazopyridine, tetrahydropyrazolopyridine, thiazolopyridine and thienopyridine.

(241) Another embodiment of the invention are compounds of Formula IIB, where R is selected from: 1H-pyrazolo[3,4-b]pyridine; 1,4,6,7-Tetrahydro-pyrazolo[4,3-c]pyridine; 7,8-Dihydro-5H-pyrido[4,3-d]pyrimidine; 5,7-Dihydro-pyrrolo[3,4-b]pyridine; 7,8-Dihydro-5H-[1,6]naphthyridine; 1,4,6,7-Tetrahydro-imidazo[4,5-c]pyridine; 1,8a-dihydroimidazo[1,2-a]pyridine; thieno[3,2-c]pyridine; 1H-imidazo[1,2-b]pyrazole; 1H-pyrazolo[3,4-b]pyridine; furo[2,3-c]pyridine; 1H-pyrazolo[3,4-b]pyridine; 1H-pyrrolo[3,2-c]pyridine; thieno[2,3-b]pyridine; imidazo[1,2-a]pyrimidine; furo[2,3-c]pyridine; isoquinoline; 1H-indazole; imidazo[1,2-a]pyridine; thieno[2,3-c]pyridine; furo[2,3-c]pyridine; 1H-pyrrolo[2,3-c]pyridine; imidazo[1,2-a]pyrazine; 1,3-benzothiazole; benzo[d]thiazole; 1H-pyrrolo[2,3-b]pyridine; [1,3]thiazolo[5,4-c]pyridine; [1,2,3,4]tetrazolo[1,5-a]pyridine; 1,5-naphthyridine; 1H-indole; 1H-imidazo[4,5-c]pyridine; and 1,6-naphthyridine.

(242) Another embodiment of the invention is compounds of Formula IIB where R is substituted at a position adjacent to a nitrogen atom on its cycle.

(243) Another embodiment of the invention si compounds of Formula B wherein R is selected from the group consisting of:

(244) ##STR00050##

(245) Still another embodiment of the invention is compounds of Formula IIB where R.sup.1 is NHR.sup.4, R.sup.4 is cycloalkyl, heterocycloalkyl, aryl or heteroaryl.

(246) Yet another embodiment of the invention is compounds of Formula IIB, where R.sup.4 is unsubstituted or substituted cycloalkyl.

(247) Another embodiment of the invention is compounds of Formula IIB, where R.sup.4 is unsubstituted or substituted heterocycloalkyl.

(248) Another embodiment of the invention is compounds of Formula IIB, where R.sup.4 is unsubstituted or substituted aryl.

(249) Yet another embodiment of the invention is compounds of Formula IIB, where R.sup.4 is unsubstituted or substituted heteroaryl.

(250) Still another embodiment of the invention is compounds of Formula IIB, where R.sup.1 is unsubstituted or substituted C.sub.3-C.sub.10-cycloalkyl.

(251) Another embodiment of the invention is compounds of Formula IIB, where R.sup.1 is unsubstituted or substituted aryl.

(252) One embodiment of the invention is compounds of Formula IIB, where R is unsubstituted or substituted 5 to 10 membered monocyclic or bicyclic heteroaryl comprising 1, 2, 3 or 4 heteroatom(s) selected from N, S or O.

(253) Another embodiment of the invention is compounds of Formula IIB, where R or R.sup.4 is selected from the group consisting of: 6-methoxypyridine; 2-ethoxy-4-fluorophenyl; 3,4-difluorophenyl; 3,4-dimethoxyphenyl; 3,4-dimethoxyphenyl; 3-chloro-5-fluorophenyl; 3-fluoro-4-methoxyphenyl; 4-chloro-2-methylphenyl; 4-fluoro-2-methoxyphenyl; 4-methoxy-2,5-dimethylphenyl; 4-methylphenyl; 5-chloro-2-ethoxyphenyl; 5-fluoro-2-methoxyphenyl; 1-(3-chlorophenyl)-1H-pyrazole; 1-(4-fluorophenyl)-1H-pyrazole; 1-(propan-2-yl)-1H-pyrazole; 1,3-thiazole; 1,4-dimethyl-1H-imidazole; 1,5-dimethyl-1H-imidazole; 1-benzothiophene; 1H-indole; 1-methyl-1H-1,3-benzodiazole; 1-methyl-1H-indazole; 1-methyl-1H-indole; 1-methyl-1H-pyrazole; 1-methyl-3-(trifluoromethyl)-1H-pyrazole; 1-methyl-5-(trifluoromethyl)-1H-pyrazole; 1-propyl-1H-pyrazole; 2-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl; 2-(3-fluorophenyl)-1,3-thiazole; 2-(benzyloxy)-5-(trifluoromethyl)phenyl; 2-(benzyloxy)phenyl; 2-(dimethylamino)pyrimidine; 2-(dimethylcarbamoyl)phenyl; 2-(ethoxymethyl)phenyl; 2-(methylsulfamoyl)phenyl; 2-(morpholin-4-yl)pyridine; 2-(morpholin-4-yl)pyridine; 2-(morpholin-4-ylmethyl)phenyl; 2-(pyrrolidin-1-yl)-1,3-thiazole; 2-(trifluoromethoxy)phenyl; 2-(trifluoromethoxy)phenyl]; 2-(trifluoromethyl)imidazo[1,2-a]pyridine; 2-(trifluoromethyl)phenyl; 2-(trifluoromethyl)pyridine; 2,3,6-trimethoxyphenyl; 2,3-difluoro-6-methoxyphenyl; 2,3-difluorophenyl; 2,3-dihydro-1,4-benzodioxine; 2,3-dihydro-1-benzofuran; 2,3-dihydro-1-benzofuranphenyl; 2,3-dimethoxy-5-methylphenyl; 2,3-dimethoxyphenyl; 2,3-dimethylphenyl; 2,4,5-trimethylphenyl; 2,4-bis(trifluoromethyl)phenyl; 2,4-dichloro-3-methoxyphenyl; 2,4-difluorophenyl; 2,4-dimethoxyphenyl; 2,4-dimethylphenyl; 2,5-difluorophenyl; 2,5-dimethoxyphenyl; 2,5-dimethylphenyl; 2,6-dichloro-3-methylphenyl; 2,6-dichlorophenyl; 2,6-dimethoxy-4-methylphenyl; 2,6-dimethoxypyridine; 2,6-dimethylphenyl; 2-[ethyl(methyl)amino]-1,3-thiazole; 2-acetylphenyl; 2-butoxy-4-fluorophenyl; 2-butoxy-5-chiorophenyl; 2-butoxy-6-fluorophenyl; 2-chloro-3-(trifluoromethyl)phenyl; 2-chloro-3-fluorophenyl; 2-chloro-4-(trifluoromethyl)phenyl; 2-chloro-4-fluorophenyl; 2-chloro-4-methoxyphenyl; 2-chloro-4-methylphenyl; 2-chloro-5-(hydroxymethyl)phenyl; 2-chloro-5-(trifluoromethoxy)phenyl; 2-chloro-5-(trifluoromethyl)phenyl; 2-chloro-5-fluorophenyl; 2-chloro-5-methoxyphenyl; 2-chloro-5-methoxyphenyl; 2-chloro-5-methylphenyl; 2-chloro-6-fluorophenyl; 3-trifluoromethylphenyl; 2-chloro-6-methoxyphenyl; 2-chlorophenyl; 2-cyanophenyl; 2-ethoxy-4-fluorophenyl; 2-ethoxy-6-fluorophenyl; 2-ethoxyphenyl; 2-ethylphenyl; 2-fluoro-3-(propan-2-yloxy)phenyl; 2-fluoro-3-(trifluoromethoxy)phenyl; 2-fluoro-3-methoxyphenyl; 2-fluoro-3-methylphenyl; 2-fluoro-4-(1H-pyrazol-1-yl)phenyl; 2-fluoro-4-(trifluoromethyl)phenyl; 2-fluoro-4-methoxyphenyl; 2-fluoro-4-methylphenyl; 2-fluoro-5-methoxyphenyl; 2-fluoro-5-methylphenyl; 2-fluoro-6-methoxyphenyl; 2-fluoro-6-propoxyphenyl; 2-fluorophenyl; 2H-1,3-benzodioxole; 2-methanesulfonamidophenyl; 2-methanesulfonylphenyl; 2-methoxy-3-(trifluoromethyl)phenyl; 2-methoxy-4-(1H-pyrazol-1-yl)phenyl; 2-methoxy-4-(trifluoromethyl)phenyl; 2-methoxy-5-(propan-2-yl)phenyl; 2-methoxy-5-(trifluoromethoxy)phenyl; 2-methoxy-5-methylphenyl; 2-methoxy-6-(propan-2-yloxy)phenyl; 2-methoxyphenyl; 2-methyl-1,3-thiazole; 2-methyl-2H-indazole; 2-methyl-4-(1H-pyrazol-1-yl)phenyl; 2-methyl-4-(trifluoromethyl)phenyl; 2-methyl-4-propoxyphenyl; 2-methylphenyl; 2-methylpyridine; 2-phenoxyphenyl; 2-phenylethane; 3-(1H-pyrazol-1-yl)phenyl; 3-(2,2,2-trifluoroethoxy)phenyl; 3-(2-methylpropoxy)phenyl; 3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl; 3-(4-fluorophenoxy)phenyl; 3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl; 3-(cyclopentylcarbamoyl)phenyl; 3-(diethylcarbamoyl)-5-fluorophenyl; 3-(difluoromethoxy)phenyl; 3-(dimethylsulfamoyl)phenyl; 3-(ethanesulfonyl)phenyl; 3-(ethylcarbamoyl)phenyl; 3-(methoxymethyl)phenyl, 3-(methylcarbamoyl)phenyl; 3-(morpholin-4-yl)phenyl; 3-(piperidin-1-yl)phenyl; 3-(piperidin-1-ylmethyl)phenyl; 3-(piperidin-1-ylphenyl; 3-(propan-2-yl)phenyl; 3-(propan-2-yloxy)phenyl; 3-(propane-1-sulfonamido)phenyl; 3-(pyrimidin-2-yl)phenyl; 3-(trifluoromethoxy)phenyl; 3-(trifluoromethyl)phenyl; 3,4-dichlorophenyl; 3,4-dimethoxyphenyl; 3,4-dimethylphenyl; 3,5-dichlorophenyl; 3,5-difluorophenyl; 3,5-dimethoxyphenyl; 3,5-dimethylphenyl; 3-[(2-methylpropyl)carbamoyl]phenyl; 3-[(dimethylamino)methylphenyl; 3-[(morpholin-4-yl)carbonyl]phenyl; 3-[(propan-2-yl)carbamoyl]phenyl; 3-[2-(dimethylamino)ethoxyphenyl; 3-[2-(dimethylamino)ethyl]phenyl; 3-[2-(morpholin-4-yl)ethoxy]phenyl; 3-acetylphenyl; 3-butoxyphenyl; 3-chloro-2-(morpholin-4-yl)pyridine; 3-chloro-2-fluorophenyl; 3-chloro-2-methoxyphenyl; 3-chloro-2-methylphenyl; 3-chloro-4-(trifluoromethyl)phenyl; 3-chloro-4-methoxyphenyl; 3-chloro-4-methylphenyl; 3-chloro-4-propoxyphenyl; 3-chloro-5-(diethylcarbamoyl)phenyl; 3-chloro-5-(hydroxymethyl)phenyl; 3-chloro-5-fluorophenyl; 3-chloro-5-methoxyphenyl; 3-chloro-5-methylphenyl; 3-chlorophenyl; 3-cyanophenyl; 3-ethoxy-2-fluorophenyl; 3-ethoxy-4-fluorophenyl; 3-ethoxyphenyl; 3-ethylphenyl; 3-fluoro-2-methoxyphenyl; 3-fluoro-2-methylphenyl; 3-fluoro-2-methylphenyl; 3-fluoro-4-(1H-pyrazol-1-yl)phenyl; 3-fluoro-4-(2,2,2-trifluoroethoxy)phenyl; 3-fluoro-4-(methylsulfanyl)phenyl; 3-fluoro-4-(trifluoromethoxy)phenyl; 3-fluoro-4-(trifluoromethyl)phenyl; 3-fluoro-4-methoxyphenyl; 3-fluoro-4-methylphenyl; 3-fluoro-4-propoxyphenyl; 3-fluoro-5-(2,2,2-trifluoroethoxy)phenyl; 3-fluoro-5-(2-methylpropoxy)phenyl; 3-fluoro-5-(morpholin-4-yl)phenyl; 3-fluoro-5-(pyrrolidin-1-yl)phenyl; 3-fluoro-5-(trifluoromethyl)phenyl; 3-fluoro-5-methoxyphenyl; 3-fluoro-5-methylphenyl; 3-fluorophenyl; 3-hydroxyphenyl; 3-methanesulfonylphenyl; 3-methoxy-4-methylphenyl; 3-methoxy-5-methylphenyl; 3-methoxyphenyl; 3-methylphenyl; 3-phenylphenyl; 3-phenylpropane; 3-propoxyphenyl; 3-sulfamoylphenyl; 3-tert-butylphenyl; 4-(1-cyanocyclopentyl)phenyl; 4-(1H-imidazol-1-yl)phenyl; 4-(1H-imidazol-1-ylmethyl)phenyl; 4-(1H-pyrazol-1-yl)phenyl; 4-(2-methylpropoxy)phenyl; 4-(4-ethoxyphenyl)phenyl; 4-(4-methylpiperazin-1-yl)phenyl; 4-(difluoromethyl)-3-fluorophenyl; 4-(dimethylcarbamoyl)phenyl; 4-(ethoxymethyl)phenyl; 4-(ethylcarbamoyl)phenyl; 4-(hydroxymethyl)phenyl; 4-(morpholin-4-yl)phenyl; 4-(propan-2-yl)phenyl; 4-(propan-2-yloxy)phenyl; 4-(pyrrolidin-1-yl); 4-(pyrrolidin-1-yl)phenyl; 4-(trifluoromethoxy)phenyl; 4-(trifluoromethyl)phenyl; 4-(trifluoromethyl)pyridine; 3,5-difluorophenyl; 4,5-difluoro-2-methoxyphenyl; 4-[(1R)-1-hydroxybutylphenyl; (dimethylamino)methylphenyl; 4-[(pyrrolidin-1-yl)carbonyl]phenyl; 4-[2-(dimethylamino)ethyl]phenyl; 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl; 4-acetylphenyl; 4-butoxy-2-methylphenyl; 4-butoxy-3-chlorophenyl; 4-butoxy-3-fluorophenyl; 4-butoxyphenyl; 4-butylphenyl; 4-chloro-2-(trifluoromethyl)phenyl; 4-chloro-2-ethoxyphenyl; 4-chloro-2-methoxyphenyl; 4-chloro-2-methylphenyl; 4-chloro-3-(trifluoromethyl)phenyl; 4-chloro-3-fluorophenyl; 4-chloro-3-methoxyphenyl; 4-chlorophenyl; 4-cyanophenyl; 4-cyclohexylphenyl; 4-ethoxy-2-methylphenyl; 4-ethoxy-3-fluorophenyl; 4-ethoxyphenyl; 4-ethylphenyl; 4-fluoro-2-(propan-2-yloxy)phenyl; 4-fluoro-2,5-dimethylphenyl; 4-fluoro-2-methoxyphenyl; 4-fluoro-2-methylphenyl; 4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl; 4-fluoro-3-(trifluoromethyl)phenyl; 4-fluoro-3-[(propan-2-yl)carbamoyl]phenyl; 4-fluoro-3-methoxyphenyl; 4-fluoro-3-methylphenyl; 4-fluorophenyl; 4-methanesulfonylphenyl; 4-methoxy-2-(trifluoromethyl)phenyl; 4-methoxy-2,5-dimethylphenyl; 4-methoxy-2-methylphenyl; 4-methoxy-3,5-dimethylphenyl; 4-methoxy-3-methylphenyl; 4-methoxyphenyl; 4-methylphenyl; 4-methylpyridine; 4-methylthiophene; 4-phenylbutane; 4-phenylphenyl; 4-phenyl-phenyl; 4-propoxyphenyl; 3,5-difluorophenyl; 5-(diethylcarbamoyl)-2-fluorophenyl; 5-(dimethylamino)pyrazine; 5-(pyrrolidin-1-yl)pyridine; 5-(trifluoromethyl)pyridine; 5-acetyl-2-methoxyphenyl; 5-chloro-2-(2,2,2-trifluoroethoxy)phenyl; 5-chloro-2-(2,2-difluoroethoxy)phenyl; 5-chloro-2-(prop-2-yn-1-yloxy)phenyl; 5-chloro-2-(propan-2-yloxy)phenyl; 5-chloro-2-ethoxyphenyl; 5-chloro-2-hydroxyphenyl; 5-chloro-2-methoxyphenyl; 5-chloro-2-methylphenyl; 5-chloro-2-propoxyphenyl; 5-chloropyridine; 5-cyano-2-methoxyphenyl; 5-fluoro-2-(hydroxymethyl)phenyl; 5-fluoro-2-methoxyphenyl; 5-fluoro-2-methylphenyl; 5-fluoro-6-methylpyridine; 5-fluoropyridine; 5H,6H,7H,8H,9H-imidazo[1,2-a]azepine; 5H,6H,7H,8H,9H-imidazo[1,2-a]azepinephenyl; 5-hydroxy-(4-phenylphenyl); 5-hydroxy-1-methyl-1H-indazole; 5-hydroxy-2-(trifluoromethoxy)phenyl; 5-hydroxy-3-(morpholin-4-yl)phenyl; 5-hydroxy-3-(piperidin-1-ylphenyl; 5-hydroxy-3-(pyrrolidin-1-ylphenyl; 5-methoxypyridine; 5-methylpyridine; 5-methylthiophene; 5-tert-butyl-2-methoxyphenyl; 6-(1H-pyrazol-1-yl)pyridine; 6-(3,4-difluorophenyl)pyridine; 6-(4-methylpiperazin-1-yl)pyridine; 6-(dimethylamino)pyridine; 6-(morpholin-4-yl)pyridine; 6-(trifluoromethyl)pyridine; 6-amino-(3,5-difluorophenyl); 6-chloro-2-fluoro-3-methylphenyl; 6-chloroimidazo[1,2-a]pyridine; 6-chloroimidazo[1,2-a]pyridinephenyl; 6-methoxynaphthalene; 6-methoxypyridine; 6-methylpyrazine; 6-methylpyridine; 8-thiatricyclo[7.4.0.0]trideca-1(13),2,4,6,9,11-hexaene; b6-chloroimidazo[1,2-a]pyridine; Cyclohexane; dimethyl-1,3-thiazole; furan; isoquinoline; naphthalene; naphthalenephenyl; phenoxathiine; phenyl; pyridine and quinoline.

(254) Another embodiment of the invention is compounds of Formula IIB, where R.sup.1 is cycloalkyl, aryl or heteroaryl, wherein each of said cycloalkyl, aryl, or heteroaryl is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of: halo, hydroxy, hydroxyalkyl, cyano, alkyl, alkynyl, alkynylalkoxy, alkoxyalkyl, alkoxy, haloalkyl, haloalkoxy, —C(O)NH(alkyl), —C(O)NH(cycloalkyl), —C(O)N(alkyl).sub.2, arylalkoxy-, aryloxy-, cycloalkyl, heterocycloalkyl, aryl, (heterocycloalkyl)alkyl-, (heterocycloalkyl)alkoxy-, —C(O)heterocycloalkyl, heteroaryl, (heteroaryl)alkyl-, —S(O).sub.2-alkyl, —S-alkyl, —C(O)alkyl, —S(O.sub.2)NH.sub.2, —S(O.sub.2)NH(alkyl), —S(O.sub.2)N(alkyl).sub.2, —N(H)(SO.sub.2)(alkyl), wherein each of said cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be substituted by one or more halo, cyano, alkyl or alkoxy; and z is 0, 1 or 2.

(255) Still another embodiment of the invention is compounds of Formula IC, where R.sup.1 is cycloalkyl, aryl or heteroaryl, wherein each of said cycloalkyl, aryl, or heteroaryl is unsubstituted or substituted with 1, 2, 3, 4 or 5 substituents which can be the same or different and are independently selected from the group consisting of: halo, haloalkyl and haloalkoxy.

(256) Another embodiment of the invention is compounds of Formula IIB, where haloalkyl is —CH.sub.zF.sub.3-z, —CH.sub.2CH.sub.zF.sub.3-z, and z is 0, 1 or 2.

(257) One embodiment of the invention is compounds of Formula IIB, where haloalkoxy is —OCH.sub.zF.sub.3-z, and z is 0, 1 or 2.

(258) Another embodiment of the invention is compounds of Formula IIB, where halo is F.

(259) Another embodiment of the invention is compounds of Formula IIB, where R is 1H-pyrazolo[3,4-b]pyridine.

(260) Another embodiment of the invention is compounds of Formula IIB, where R is 1,8a-dihydroimidazo[1,2-a]pyridine.

(261) Anyone or more embodiments of Formula IIB provided above may be combined with one or more other embodiments of Formula IIB as provided above.

(262) In another embodiment, the invention is further illustrated by the compounds shown in Table 2:

(263) TABLE-US-00002 TABLE 2 N-[4-(piperidine-1-sulfonyl)phenyl]-3- (pyridin-3-yl)propanamide N-[4-(pipaeridine-1-sulfonyl)phenyl]-2- (pyridin-3-yloxy)acetamide N-[4-(piperidine-1-sulfonyl)phenyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}thieno[2,3- b]pyridine-2-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1H-pyrrolo[2,3- c]pyridine-2-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1H-indazole-5- carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 0 N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1H-imidazo[1,2- b]pyrazole-5-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}thieno[3,2- c]pyridine-2-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}- [1,2,3,4]tetrazolo[1,5-a]pyridine-7- carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-7-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1,6- naphthyridine-2-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}pyridine-3- carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1H-1,3- benzodiazole-5-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}-1,3- benzothiazole-6-carboxamide N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}furo[3,2- c]pyridine-2-carboxamide N-{1-[4-(piperidine-1- sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-[(4-{8-oxa-3-azabicyclo[3.2.1]octane- 3-sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{8-oxa-3-azabicyclo[3.2.1]octane- 3-sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{8-oxa-3-azabicyclo[3.2.1]octane- 3-sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(5-chloro-2- methoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(2- acetylphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-2-methoxy-5- methylphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2- propoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(5-fluoro-2- methoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(quinolin-8- yl)sulfamoyl]phenyl}methyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(piperidin-1- yl)phenyl]sulfamoyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide 0 N-[(4-{[2-(morpholin-4- yl)phenyl]sulfamoyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-methoxy-2- methylphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(propan-2- yloxy)phenyl]sulfamoyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2- phenoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(3-methoxy-2- methylphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2- methoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2-(trifluoro- methoxy)phenyl]sulfamoyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(5,6,7,8-tetrahydronaphthalen-1- yl)sulfamoyl]phenyl}methyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2- methoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(2-methoxy-6- methylphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 0 N-({4-[(4-methoxy-2- methylphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2,3-dihydro-1,4-benzodioxin-6- yl)sulfamoyl]phenyl}methyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(2-hydroxy- ethoxy)phenyl]sulfamoyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(4-ethoxy-2- fluorophenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(hydroxy- methyl)phenyl]sulfamoyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(1-oxo-1H-isochromen-5- yl)sulfamoyl]phenyl}methyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4- benzenesulfonamidophenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-{[1-(benzenesulfonyl)piperidin-4- yl]methyl}-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-benzamidophenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(trifluoromethoxy)benzene]sulfon- amido}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine- 2-carboxamide 00 N-{[4-(piperidine-1- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 01 N-({4-[(2,5- dimethoxyphenyl)sulfamoyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 02 N-[(4-{[2-methoxy-5-(trifluoro- methyl)phenyl]sulfamoyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 03 N-[(4-{[4-chloro-2-(trifluoro- methoxy)phenyl]sulfamoyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 04 N-({4-[(1H-indazol-6- yl)sulfamoyl]phenyl}methyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide 05 6-Amino-1H-pyrrolo[3,2-c]pyridine-2- carboxylic acid 4-(piperidine-1-sulfonyl)- benzylamide 06 1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid 4-(piperazine-1-sulfonyl)- benzylamide 07 1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid 4-(4-amino-cyclohexylsulfamoyl)- benzylamide 08 1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid 4-(3-amino-pyrrolidine-1-sulfonyl)- benzylamide 09 1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid 4-(3,8-diaza-bicyclo[3.2.1]octane-3- sulfonyl)-benzylamide 0 Imidazo[1,2-a]pyrimidine-6-carboxylic acid 4-(piperazine-1-sulfonyl)- benzylamide Thieno[2,3-c]pyridine-2-carboxylic acid 4-(piperazine-1-sulfonyl)-benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(piperazine-1-sulfonyl)- benzylamide Thieno[2,3-c]pyridine-2-carboxylic acid 4-(4-amino-cyclohexylsulfamoyl)- benzylamide Furo[2,3-c]pyridine-2-carboxylic acid 4- (4-amino-cyclohexylsulfamoyl)- benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-amino-cyclohexylsulfamoyl)- benzylamide Thieno[2,3-c]pyridine-2-carboxylic acid 4-(3-amino-pyrrolidine-1-sulfonyl)- benzylamide Imidazo[1,2-a]pyridine-6-carboxylic acid 4-(3-amino-pyrrolidine-1-sulfonyl)- benzylamide Furo[2,3-c]pyridine-2-carboxylic acid 4- (3-amino-pyrrolidine-1-sulfonyl)- benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(3-amino-pyrrolidine-1-sulfonyl)- benzylamide 0 Imidazo[1,2-a]pyridine-6-carboxylic acid 4-(piperazine-1-sulfonyl)-benzylamide Furo[2,3-c]pyridine-2-carboxylic acid 4- (piperazine-1-sulfonyl)-benzylamide Imidazo[1,2-a]pyrimidine-6-carboxylic acid 4-(3-amino-pyrrolidine-1-sulfonyl)- benzylamide Imidazo[1,2-a]pyrimidine-6-carboxylic acid 4-(4-amino-cyclohexylsulfamoyl)- benzylamide Imidazo[1,2-a]pyridine-6-carboxylic acid 4-(4-amino-cyclohexylsulfamoyl)- benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-cyano-piperidine-1-sulfonyl)- benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-cyanomethyl-piperidine-1- sulfonyl)-benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-methoxy-piperidine-1-sulfonyl)- benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-(4-amino-piperidine-1-sulfonyl)- benzylamide 1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 4-[4-(2,2,2-trifluoro-ethylamino)- piperidine-1-sulfonyl]-benzylamide 0 N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-chloro-2- ethoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2-chloro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(5-acetyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2,2,2-trifluoro- ethoxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[1-methyl-5-(trifluoromethyl)-1H- pyrazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4- (benzenesulfonyl)phenyl]methyl}iso- quinoline-6-carboxamide 0 N-[(4-{[3-(trifluoro- methyl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(piperidin-1- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(trifluoromethyl)pyridine-3- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4- butylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(2-methylpyridine-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4-methoxy-3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-butoxy-3- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-methane- sulfonylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-chloro-5- (hydroxymethyl)benzene]sulfo- nyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6- carboxamide 0 N-[(4-{[3-(diethylcarbamoyl)-5- fluorobenzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-chloro-6- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-chloro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2,3- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[3-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(4- acetylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-({3-[(2- methylpropyl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2-chloro-6- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-fluoro-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide 0 N-{[4-({4-[2-(pyrrolidin-1- yl)ethoxy]benzene}sulfonyl)phenyl]methyl}- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-butoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-fluoro-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-methyl-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3- ethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3- phenylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-chloro-3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[5-chloro-2-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 0 N-({4-[(4- butoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,5- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(5-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-({3-[2-(morpholin-4- yl)ethoxy]benzene}sulfonyl)phenyl]meth- yl}thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-ethoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4- chlorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4- ethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-ethoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-({4-[(3-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-(1- cyanocyclopentyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4-fluoro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(5-chloro-3-methylpyridine-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(isoquinoline-4- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 0 N-({4-[(5-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[3-chloro-5- (diethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3,4- difluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-(4-methylpiperazin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-pyrrolo[2,3-c]pyridine-3-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 00 N-({4-[(3-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 01 N-({4-[(2-chloro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 02 N-{[4-(quinoline-6- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 03 N-{[4-(1-methyl-1H-indazole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 04 N-({4-[(5-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 05 N-{[4-(1-propyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 06 N-({4-[3,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 07 N-({4-[(3-fluoro-5- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 08 N-({4-[(4-ethyl- benzene)sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide 09 N-({4-[(2,4,5- trimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[2-(trifluoromethyl)imidazo[1,2- a]pyridine-6-sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-methyl- benzene)sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-4-propoxy- benzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-fluoro-6-propoxy benzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2-(morpholin-4- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(5-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-(2,2,2-trifluoroethoxy)-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-({4-[(2-fluoro-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{2-[4-(benzenesulfonyl)phenyl]ethyl}- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[4-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(3- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3- ethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-b]pyridine-2-carboxamide N-{[4-(6-methoxypyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 0 N-({4-[6-(dimethylamino)pyridine-3- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3- (methoxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-butoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3- hydroxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-fluoro-2-methoxy benzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(5-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-ethoxy-2- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[(2- ethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-ethoxy-3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(morpholin-4- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-fluoro-6- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(2-methylpyridine-3- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{8-oxatricyclo[7.4.0.0.sup.2,.sup.7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4- phenylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-[(4-{[2-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(5-chloro-2- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-{[4-(2H-1,3-benzodioxole-5- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-({4-[(1R)-1- hydroxybutyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(5-methylthiophene-2- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-({3-[2-(morpholin-4- yl)ethoxy]benzene}sulfonyl)phenyl]meth- yl}imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(benzene- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrazine-2-carboxamide N-({4-[(4- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(quinoline-8- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 0 N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3,4- dichlorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-({4-fluoro-3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2,4- bis(trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(1-methyl-1H-indazole-6- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-fluoro-3- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2,4- bis(trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2-methyl-4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-({4-[(3- phenylbenzene)sulfonyl]phenyl}methyl)- 1,3-benzothiazole-6-carboxamide N-[(4-{[4- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- (cyclopentylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4,5-difluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3- (methoxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-4- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 0 N-[(4-{[5-chloro-2-(prop-2-yn-1- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3- phenylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-({4-[(3- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[6-(dimethylamino)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(5-chloro-2- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-methoxy-3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3- cyanobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-({4-[(2,6-dichloro-3- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3- thiazole-5- sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(4-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(1-propyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-[(4-{[4-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 00 N-({4-[(2- methanesulfonamidobenzene)sulfo- nyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 01 N-{[4-(2,3-dihydro-1,4-benzodioxine-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 02 N-({4-[2-(dimethylamino)pyrimidine-5- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 03 N-({4-[(2-methyl-4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 04 N-({4-[(2-methoxy-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 05 N-({4-[(2,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide 06 N-({4-[2-(dimethylamino)pyrimidine-5- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 07 N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide 08 N-({4-[1-(4-fluorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide 09 N-[(4-{[4-methoxy-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-({4-[(4-ethoxy-3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-(4-methylpyridine-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-({3-[2-(morpholin-4- yl)ethoxy]benzene}sulfonyl)phenyl]meth- yl}imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-fluoro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 3-(pyridin-2-yl)-1H-pyrazole-5- carboxamide N-[(4-{[3-(5-methyl-1,2,4-oxadiazol-3- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(1,3-thiazole-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-(4-(2- (trifluoromethoxy)phenylsulfo- nyl)benzyl)imidazo[1,2- a]pyridine-6-carboxamide 0 N-{[4-(6-methylpyrazine-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(4,5-difluoro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2- (methylsulfamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4- (methylsulfanyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-methoxy-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-{[4-(benzenesulfonyl)phenyl]methyl}- 1-methyl-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(3-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(5-chloro-3-methylpyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3-methoxy-4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(piperidin-1- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-({4-[5-(trifluoromethyl)pyridine-3- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-fluoro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3-chloro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,4-dichloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-(4- (phenylsulfonyl)benzyl)benzo[d]thiazole- 5-carboxamide N-{[4-(quinoline-3- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 0 N-({4-[(3,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(4-ethoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(6-methylpyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-tert-butyl-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[3- (ethanesulfonyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 0 N-({4-[(4-methoxy-3- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(3-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2-methoxy-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(pyrimidin-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(6-chloro-2-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(5-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- sulfamoylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[(5-cyano-2- methoxybenzene)sulfonyl]phenyl)meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(1,3-thiazole-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3- cyanobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3- chlorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2,6- dichlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-chloro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2- phenoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-{[4-(6-methylpyrazine-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-({4-[(4- ethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- (cyclopentylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 5-hydroxy-N-({4-[(4- phenylbenzene)sulfonyl]phenyl}methyl)- 1H-indole-2-carboxamide N-[(4-{[4-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[4- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-({4-[(3-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-ethoxy-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-butoxy-3- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{8-oxatricyclo[7.4.0.0.sup.2,.sup.7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(1H-indole-7- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(naphthalene-1- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(quinoline-3- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 00 N-({4-[(4-chloro-3- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 01 N-{[4-(5-chloropyridine-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 02 N-({4-[(3-fluoro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 03 N-({4-[(4- butylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 04 N-({4-[(2,6- dichlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 05 N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 06 N-({4-[(3-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 07 N-[(4-{[3-fluoro-4-(trifluoro- methoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide 08 N-[(4-{[2-methoxy-5-(trifluoro- methoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 09 N-({4-[(4-fluoro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-{[4-(phenoxathiine-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(4- fluorophenoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(quinoline-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[4-methoxy-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(5-methyl-1,2,4-oxadiazol-3- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-({4-[(3- acetylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-butoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-butoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-{[4-({3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4,5-difluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3,4- dichlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[6-(1H-pyrazol-1-yl)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(4- ethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2,3- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3-chloro-4- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(2-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[(4- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(2-fluoro-6- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-pyrrolo[2,3-b]pyridine-5-carboxamide N-{[4-(1-benzothiophene-7- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(2-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(6-methylpyrazine-2- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[2-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-[(4-{[4-(1- cyanocyclopentyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4,5-difluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[4- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(isoquinoline-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-1,3-benzodiazole-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2- ethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2- ethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-{[4-(benzenesulfonyl)phenyl]methyl}- [1,2,4]triazolo[4,3-a]pyridine-6- carboxamide N-[(4-{[3-(5-methyl-1,2,4-oxadiazol-3- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3- ethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2,3-dimethoxy-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,6-dimethoxy-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4- (benzenesulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 0 N-[(4-{[4- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3- (methylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(5-fluoro-6-methylpyridine-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(6-chloro-2-fluoro-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-fluoro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(isoquinoline-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2,4,5- trimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-({4-[(2,4-dichloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide (E)-2-cyano-3-({4-[(5-fluoro-2- methoxyphenyl)sulfamoyl]phenyl}meth- yl)-1-(pyridin-4-yl)guanidine N-[(4-{[2-fluoro-3-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-methoxy-3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-methoxy-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2- a]pyridine-6- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1,3- benzothiazole-6-carboxamide N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-({4-[(4-fluoro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4- (phenylmethane)sulfonylphenyl]methyl}- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-5- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[4-(1- cyanocyclopentyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4- ethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(2-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-fluoro-3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide 0 N-[(4-{[2-methoxy-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(4- propoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-methoxy-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(5-chloro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2-methyl-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(3,4- difluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[4-chloro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- [1,3]thiazolo[5,4-c]pyridine-2- carboxamide 00 N-({4-[5-(pyrrolidin-1-yl)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 01 N-[(4-{[2-methyl-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide 02 N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 03 N-[(4-{[3-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 04 N-({4-[(2-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 05 N-({4-[(3-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 06 N-{[4-(5-chloro-3-methylpyridine-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 07 N-[(4-{[2- (dimethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 08 N-[(4-{[4-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-6-carboxamide 09 N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-[(4-{[4-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4-methoxy-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(propan-2- yloxy)benzene]sulfonyl}phenyl)methyl]- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-({4-[(pyrrolidin-1- yl)carbonyl]benzene}sulfonyl)phenyl]meth- yl}thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2,4,6- trimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-(benzyloxy)-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-{[4-(6-methoxypyridine-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-(1,3-benzothiazol-6-ylmethyl)-4-[(3- chlorobenzene)sulfonyl]benzamide N-({4-[(2,4-dichloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-ethoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2- a]pyridine-6- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-{[4-(phenoxathiine-4- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[1-(4-fluorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-[(4-{[2-methoxy-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3- (cyclopentylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({3-[2-(morpholin-4- yl)ethoxy]benzene}sulfonyl)phenyl]meth- yl}-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[4-fluoro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-fluoro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-5- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-fluoro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-({3-[(morpholin-4- yl)carbonyl]benzene}sulfonyl)phenyl]meth- yl}-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-(pyrimidin-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6- carboxamide 0 N-({4-[(2-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[4-fluoro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2,3- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-chloro-6- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(4-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-({4-[(5-fluoro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 5-(pyridin-3-yl)-1H-pyrazole-3- carboxamide N-({4-[(4- butylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(4- fluorophenoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[5-chloro-2-(2,2- difluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(quinoline-6- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[(5-acetyl-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4- butoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[5-(trifluoromethyl)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-{[4-(5-methoxypyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2- acetylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4- acetylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2- acetylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[4-chloro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3- phenylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(6-methoxynaphthalene-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3-chloro-5- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-({4-[(4-ethoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[4- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2- (dimethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 5-(pyridin-3-yl)-1,2,4-oxadiazole-3- carboxamide 5-hydroxy-N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- indole-2-carboxamide N-[(4-{[3- (dimethylsulfamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(6-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-[(4-{[2-methoxy-5-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(dimethylamino)pyridine-3- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-[(4-{[2- (trifluoromethoxy)benzene]sulfi- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-chloro-3- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2,4,5- trimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 00 N-({4-[(4-fluoro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide 01 N-({4-[1-(propan-2-yl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 02 N-[(4-{[3- (difluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 03 N-[(4-{[2-methoxy-6-(propan-2- yloxy)benzene]sulfonyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 04 N-({4-[(4-chloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 05 N-({4-[(2,3- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 06 N-({4-[(5-tert-butyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 07 N-({4-[(4-methoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 08 N-({4-[(2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 09 N-({4-[(2-fluoro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-[(4-{[2-chloro-5- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4-fluoro-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(4-butoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-fluoro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[5-chloro-2-(2,2- difluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-butoxy-5- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2-chloro-3- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide 0 N-[(4-{[3-fluoro-5-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-fluoro-5- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(3-chloro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-([2,4- bis(trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2- ethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- phenylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-methoxy-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 0 N-({4-[(2-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(isoquinoline-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-[(4-{[2-chloro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[5-(diethylcarbamoyl)-2- fluorobenzene]sulfonyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-6- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidaze[1,2-a]pyrimidine-6-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2- a]azepine-3- sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4- butoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-({4-[(5-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4- (methylsulfanyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3-tert- butylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(5-tert-butyl-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[4-fluoro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-butoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-({4-[(3-methoxy-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3- sulfonyl]phenyl}methyl)-1,3- benzothiazole-6-carboxamide N-{[4-(5-fluoro-6-methylpyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(phenoxathiine-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2- (methylsulfamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 0 N-[(4-{[2- (methylsulfamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4- ethoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-fluoro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[4-(1- cyanocyclopentyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-methoxy-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4- cyclohexylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-{[4-({4-[2- (dimethylamino)ethyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(5-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4- (benzenesulfonyl)phenyl]meth- yl}quinazoline-6-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1,3- benzothiazole-6-carboxamide N-({4-[(3,5- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-chloro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-butoxy-3- chlorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-({4-[(4- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-({3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2,3-dimethoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-fluoro-3-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(5-methoxypyridine-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-chloro-2- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[5-hydroxy-2- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 0 N-({4-[(3,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[4-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2-butoxy-4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N′-(4-tosylphenyl)imidazo[1,2-a]pyridine- 6-carbohydrazide N-({4-[(3,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-(isoquinoline-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,6- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-methoxy-3,5- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 00 N-{[4-(benzenesulfonyl)phenyl]methyl}- [1,2,3,4]tetrazolo[1,5-a]pyridine-6- carboxamide 01 N-({4-[(4- cyanobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 02 N-{[4-({3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 03 N-({4-[(2,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 04 N-({4-[(4-butoxy-3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 05 N-{[4-(4-methylpyridine-3- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 06 N-[(4-{[2- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 07 N-({4-[(4- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 08 N-[(4-{[4-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 09 N-({4-[(3-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-chloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3- cyanobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[6-(dimethylamino)pyridine-3- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-ethoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2- (benzyloxy)benzene]sulfonyl}phenyl)meth- yl]-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(5-acetyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-butoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3- thiazole-5- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(4- ethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(4-chloro-3- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(2-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(5-fluoropyridine-3- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 0 N-{[4- (benzenesulfonyl)phenyl]methyl}thieno[2,3- b]pyrazine-6-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-butoxy-5- chlorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3- thiazole-5- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(quinoline-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3-ethoxy-2- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(morpholin-4- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(4-methoxy-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{4-[(3-fluoro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-{[4-(methylpyridine-3- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(propane-1- sulfonamido)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-fluoro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-chloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-({3-[2- (dimethylamino)ethoxy]benzene}sulfo- nyl)phenyl]methyl}furo[2,3-c]pyridine-2- carboxamide N-{[4-(2-methyl-2H-indazole-6- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-[(4-{[3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- (cyclopentylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-fluoro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2- cyanobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-{[4-(5-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-chloro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide 0 N-[(4-{[3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(2- acetylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-3- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 5-hydroxy-N-{[4-(1-methyl-1H-indazole- 4-sulfonyl)phenyl]methyl}-1H-indole-2- carboxamide N-{[4-(2,6-dimethoxypyridine-3- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-butoxy-6- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(naphthalene-1- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1-methyl-1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[1-methyl-5-(trifluoromethyl)-1H- pyrazole-4-sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3- ethoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-{[4-(6-methylpyridine-3- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-chloro-5- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[1-(4-fluorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-{[4-(quinoline-6- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 0 N-({4-[6-(3,4-difluorophenyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(1,5-dimethyl-1H-imidazole-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2- (dimethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-chloro-3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]thiene[2,3-c]pyridine-2-carboxamide N-({4-[(2,6- dichlorobenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(4- acetylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-{[4-({4-[(1R)-1- hydroxybutyl]benzene}sulfonyl)phenyl]meth- yl}furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-({3-[2- (dimethylamino)ethyl]benzene}sulfo- nyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2- ethoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2- ethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(1,5-dimethyl-1H-imidazole-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-5- hydroxy-1H-indole-2-carboxamide 00 N-({4-[(5-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 01 N-({4-[(2,3-dimethoxy-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 02 N-({4-[(3-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide 03 N-{[4-(isoquinoline-4- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 04 N-[(4-{[2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 05 N-({4-[6-(dimethylamino)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 06 N-[(4-{[3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 07 N-({4-[(2-butoxy-6- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 08 N-[(4-{[3- (ethanesulfonyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 09 N-{[4-(benzenesulfonyl)phenyl]methyl}- 3-(pyridin-3-yl)-1,2-oxazole-5- carboxamide 0 N-[(4-{[2-methoxy-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(1H-pyrazol-1- yl)benzene]sulfonyl)phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-chloro-4- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(5-chloro-2- propoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(5-tert-butyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3-ethoxy-4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2- a]pyridine-6- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 0 N-({4-[(4- cyanobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[4-fluoro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3,5- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(4- acetylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(5-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2,3- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[(3- acetylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2,4- bis(trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide 0 N-[(4-{[4- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(5-chloropyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-fluoro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-5- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1,3-benzothiazole-6- carboxamide N-{[4-(4-methylpyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(pyridine-3- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-({4-[(2-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-chloro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2,3- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3- ethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-5- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- sulfamoylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({3-[(2- methylpropyl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2,3,6- trimethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2-fluoro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3-methoxy-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4- (benzenesulfonyl)phenyl]meth- yl}imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-butoxy-3- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-(6-(4- (morpholinomethyl)phenoxy)hexyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-ethoxy-2- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-(4-methylpiperazin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(quinoline-8- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4-chloro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-({4-[6-(dimethylamino)pyridine-3- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[(5-chloro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(1,4-dimethyl-1H-imidazole-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4- (benzenesulfonyl)phenyl]meth- yl}imidazo[1,2-a]pyrimidine- 6-carboxamide 0 N-({4-[(3- propoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(5-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2H-1,3-benzodioxole-4- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2- a]azepine-3-sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(6-methoxynaphthalene-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-{[4-(5-fluoropyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2,4-dichloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(5-fluoro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-{[4-(naphthalene-1- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-({4-[2- (dimethylamino)ethyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-methyl-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2,3,6- trimethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3- butoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-chloro-2- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-{[4-(5-chloropyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[4- (dimethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[4- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-(1-methyl-1H-indazole-6- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-(1H-indole-7- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-tert- butylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide 00 N-{[4-({3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 01 N-({4-[(2,3-dimethoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 02 N-{[4-(benzenesulfonyl)phenyl]methyl}- 1,5-naphthyridine-2-carboxamide 03 5-hydroxy-N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- indole-2-carboxamide 04 N-[(4-{[3-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide 05 N-({4-[(2-methyl-4- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 06 N-{[4-({3- [(dimethylamino)methyl]benzene}sulfo- nyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 07 N-({4-[(3- chlorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 08 N-{[4-(5-fluoropyridine-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 09 N-[(4-{[3-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 0 N-{[4-(2,3-dihydro-1,4-benzodioxine-6- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-methoxy-3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzen]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2,4,6- trimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-(4-methylpiperazin-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3- (ethanesulfonyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-2-carboxamide N-{[4-({3-[2- (dimethylamino)ethyl]benzene}sulfo- nyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 0 N-({4-[(4-methoxy-3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3,4- difluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(2- ethoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,6- dichlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-fluoro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(2-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 0 N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2- ethylbenzene)sulfonyl]phenyl}meth- yl)fur[2,3-c]pyridine-2-carboxamide N-({4-[(4- phenylbenzene)sulfonyl]phenyl}methyl)- 1,3-benzothiazole-6-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1,3- benzothiazole-6-carboxamide N-[(4-{[4- (ethoxymethyl)benzene]sulfo- nyl)phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[5-(dimethylamino)pyrazine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[3-chloro-5- (diethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4- (benzenesulfonyl)phenyl]meth- yl}quinoline-6-carboxamide 0 N-({4-[(3- butoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-2-carboxamide N-({4-[(3- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2,6-dimethoxy-4- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-({4-fluoro-3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(5-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,5- dichlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-methoxy-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(4-methylpiperazin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-3- methoxybenzene)sulfonyl]phenyl)methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(4-chloro-3- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-{[4-(5-methoxypyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[2-(trifluoromethyl)pyridine-3- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-({3-[(2- methylpropyl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide 0 N-{[4-(pyridine-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-5- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-(morpholin-4- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2,6-dichloro-3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-5- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[5-fluoro-2- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-methoxy-4- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-(2-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-{[4-(6-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(1,5-dimethyl-1H-imidazole-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-2-carboxamide N-[(4-{[3-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[5-hydroxy-2- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[4-(1H-imidazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-pyrazolo[3,4-b]pyridine-3- carboxamide N-({4-[(4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,4- difluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-butoxy-3- chlorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-{[4-(1-methyl-1H-indazole-6- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[3-chloro-2-(morpholin-4- yl)pyridine-4- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(1,3-thiazole-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-chloro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(4-butoxy-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(6-methoxynaphthalene-2- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3-(propane-1- sulfonamido)benzene]sulfonyl)phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide 0 N-[(4-{[4-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-5- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-2-carboxamide N-({4-[(3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(2-methylpyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2- cyanobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(6-methylpyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 000 N-[(4-{[3- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 001 N-{[4-(1-methyl-1H-indazole-5- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 002 N-({4-[(3- acetylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 003 N-({4-[(2-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 004 N-[(4-{[4-fluoro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 005 N-({4-[(4-butoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 006 N-({4-[(3- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 007 N-({4-[(3-fluoro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide 008 N-({4-[4-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 009 N-[(4-{[4-chloro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 010 N-({4-[(4-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 011 N-{[4-(2,3-dihydro-1-benzofuran-7- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 012 N-[(4-{[3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 013 N-({4-[4-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide 014 N-[(4-{[5-chloro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide 015 N-({4-[(2-chloro-6- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 016 N-{[3-(benzenesulfonyl)phenyl]methyl}- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 017 N-[(4-{[4-fluoro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 018 N-({4-[(2- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 019 N-[(4-{[2-methoxy-5-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide 020 N-[(4-{[2-methyl-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 021 N-({4-[(2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 022 N-({4-[(2- phenoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 023 N-({4-[(4- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 024 N-({4-[(3-fluoro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-2-carboxamide 025 N-({4-[(3-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)pyrrolo[3,2-c]pyridine-2-carboxamide 026 N-[(4-{[3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide 027 N-({4-[(2-butoxy-5- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 028 N-({4-[(2-ethoxy-4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 029 N-({4-[(2-chloro-5- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 030 N-({4-[(3-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 031 N-[(4-{[3- (ethanesulfonyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide 032 N-({4-[(2- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 033 N-{[4-(4-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 034 N-({4-[(3,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide 035 N-{[4-(1,4-dimethyl-1H-imidazole-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 036 N-({4-[2-(dimethylamino)pyrimidine-5- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 037 N-{[4-(1-methyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 038 N-[(4-{[3-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 039 N-[(4-{[2-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 040 N-({4-[(3- butoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 041 N-({4-[(2,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 042 N-({4-[(4- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide 043 N-[(4-{[4-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide 044 N-[(4-{[2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 045 N-({4-[(3- acetylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 046 N-({4-[(2-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 047 N-{[4-(5-chloro-3-methylpyridine-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 048 N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 049 N-({4-[(3,5- dichlorobenzene)sulfonyl]phenyl}methyl)-1H- pyrrolo[3,2-c]pyridine-2-carboxamide 050 N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide 051 N-{[4-(5-methoxypyridine-3- sulfonyl)phenyl]methyl}thieno[2,3- c][pyridine-2-carboxamide 052 N-[(4-{[2-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 053 N-[(4-{[4-chloro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 054 N-{[4-(2-methyl-2H-indazole-6- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 055 N-(4-(phenylsulfonyl)benzyl)-1H- imidazo[4,5-b]pyridine-6-carboxamide 056 N-[(4-{[4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 057 N-{[4-(quinoline-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 058 N-({4-[(3-ethoxy-2- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 059 N-({4-[(3-fluoro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 060 N-{[4-(l-benzothiophene-7- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 061 N-[(4-{[3-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 062 N-({4-[(3,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide 063 N-({4-[6-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide 064 N-({4-[(2-chloro-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 065 N-({4-[(3- acetylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 066 N-{[4-(quinoline-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 067 N-[(4-{[3-fluoro-5-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]imidazol[1,2-a]pyridine-6-carboxamide 068 N-[(4-{[2-(morpholin-4- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 069 N-[(4-{[4-(1H-imidazol-1- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide 070 N-({4-[(4-methoxy-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 071 N-[(4-{[4-fluoro-3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide 072 N-[(4-{[3-fluoro-5-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 073 N-({4-[(2,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide 074 N-({4-[(2-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 075 N-({4-[5-(pyrrolidin-1-yl)pyridine-3- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 076 N-({4-[(3- phenylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 077 N-{[4-({4- [(dimethylamino)methyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 078 N-[(4-{[3-(diethylcarbamoyl)-5- fluorobenzene]sulfonyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 079 N-[(4-{2-[ethyl(methyl)amino]-1,3- thiazole-5- sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 080 N-({4-[(5-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 081 N-({4-[(5-chloro-2- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 082 N-[(4-{[4-(1H-imidazol-1- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-5-carboxamide 083 N-({4-[(4-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 084 N-({4-[(3-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 085 N-[(4-{[4-(2- methylpropoxy)benzene]sulfo- nyl{phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 086 N-[(4-{[4-fluoro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)methyl]- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 087 N-({4-[(2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 088 N-[(4-{[3-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide 089 N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide 090 N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2- a]azepine-3- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 091 N-({4-[(3-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 092 N-({4-[(3-chloro-5- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 093 N-{[4-(2-methyl-1,3-thiazole-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 094 N-({4-[6-(4-methylpiperazin-1- yl)pyridine-3-sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 095 N-({4-[(4-fluoro-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 096 N-{[4-(2-methyl-1,3-thiazole-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide 097 N-({4-[(2,3-dimethoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 098 N-({4-[(2- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide 099 N-[(4-{[4-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide 00 N-{[4-(quinoline-8- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 01 N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 02 N-({4-[(4- cyclohexylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 03 N-{[4-(1-propyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 04 N-({4-[(2-chloro-5- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 05 N-({4-[(2-butoxy-6- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 06 N-{[4-(5-fluoropyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 07 N-([4-({3-[2- (dimethylamino)ethyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 08 N-({4-[(2,6-dimethoxy-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 09 N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide 0 N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2- a]azepine-3- sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-tert- butylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[3-fluoro-4- (methylsulfanyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(2,3-dihydro-1,4-benzodioxine-6- sulfonyl)phenyl]methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(4- butylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indole-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(4- phenylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(4-ethoxy-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(5-chloro-3-methylpyridine-2- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-propyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(4-methylpyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-{[4-{[3- (methoxymethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(2-butoxy-5- chlorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-methyl-4- propoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{5-fluoro-2- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-[(4-{[3- (methoxymethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(5-methoxypyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[1-methyl-3-(trifluoromethyl)-1H- pyrazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-(benzyloxy)-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4- (cyclohexanesulfonyl)phenyl]methyl}-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3,4- difluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4- (benzenesulfonyl)phenyl]methyl}iso- quinoline-7-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 0 N-({4-[(2-butoxy-5- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(5-methylthiophene-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(2,6- dichlorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-{[4-({4-[(pyrrolidin-1- yl)carbonyl]benzene}sulfonyl)phenyl]meth- yl}-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-(quinoline-8- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(4-butoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-[(4-{[3-fluoro-5-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(6-methylpyrazine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}-1,3- benzothiazole-6-carboxamide N-[(4-{[3- (difluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-acetyl-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,3- dimethoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[5-fluoro-2- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 0 N-({4-[(5-tert-butyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-4- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(2,6-dimethoxypyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(2,3- difluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5-(pyrrolidin-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide 0 N-({4-[(3-fluoro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-(4-methylpiperazin-1- yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(3-ethoxy-2- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4- butylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 3-bromo-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2,6- dichlorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-({3- [(dimethylamino)methyl]benzene}sulfo- nyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-5- methoxybenene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2-methoxy-5- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 0 N-{[4-(2-methyl-1,3-thiazole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(phenoxathiine-4- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(5-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-{[4-(1-propyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-methyl-4- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- ylimidazo[1,2-a]pyrimidine-6-carboxamide 0 N-({4-[(2,3- dimethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2- methoxybenzene)sulfonyl[phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(5-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[2-chloro-5- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4- phenylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2-butoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-5- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(2,5- difluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]furo[2,3-c]pyridine-2-carboxamide N-({4-[(2,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 00 N-{[4-(5-methoxypyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 01 N-{[4-(5-fluoropyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 02 N-[(4-{2-[ethyl(methyl)amino]-1,3- thiazole-5-sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 03 N-[(4-{[4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 04 N-({4-[(3-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 05 N-({4-[(3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 06 N-[(4-{[4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 07 N-{[4-(2-methyl-2H-indazole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide 08 N-[(4-{[3-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide 09 N-{[4-(2-methyl-2H-indazole-5- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide 0 N-{[4-(quinoline-3- sulfonyl)phenyl]methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3- (dimethylsulfamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide 5-hydroxy-N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)methyl]-1H- indole-2-carboxamide N-({4-[(2- chlorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(1-benzothiophene-7-sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3-tert- butylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-chloro-2- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-({4-[(3- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- cyanobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[2- (benzenesulfonyl)ethyl]phenyl)methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[5-fluoro-2- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,5- dichlorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamid N-{[4-(4-methylthiophene-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-fluoro-4- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-{[4- (benzenesulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(5-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3- (methylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(2,6-dimethoxypyridine-3- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridinie-5-carboxamide N-[(4-{[4-methoxy-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(pyridine-3- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(4- cyclohexylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4- butoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 0 N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4- phenylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(diethylcarbamoyl)-5- fluorobenzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(5-methoxypyridine-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[2-(2,2,2-trifluoroethoxy)-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-chloro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[4-(4- ethoxyphenyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(3- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(5-chloro-2- hydroxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-({4-[(3-fluoro-4- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-fluoro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(4-methoxy-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-(6-methylpyridine-3- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2- phenoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(3- ethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]thieno[2,3-c]pyridine-2-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- sulfonyl]phenyl}methyl)-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 0 N-{[4-({3-[(2- methylpropyl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[5-chloro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(2,4- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4-fluoro-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-chloro-5- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1- yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 0 N-({4-[(4- phenylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[(3-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- sulfonyl]phenyl}methyl)thieno[2,3- c]pyridine-2-carboxamide N-({4-[(2-fluoro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(pyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3- butoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3,4- dichlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-[(4-{[2-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[2- (dimethylcarbamoyl)benzene]sulfo- nyl)phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2-chloro-5- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-(4-methylpyridine-3- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(4-butoxy-3- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3- ethylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methoxybenzene)sulfonyl]phenyl)meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[(3-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide 0 N-({4-[(2-ethoxy-6- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-fluoro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[2-(morpholin-4-yl)pyridine-3- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(2- phenoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[3-chloro-5- (diethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-({4-[(2-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[3- (ethanesulfonyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(1,4-dimethyl-1H-imidazole-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide 00 N-[(4-{[4-(propan-2- yloxy)benzene]sulfonyl}phenyl)methyl]- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 01 N-({4-[(3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide 02 N-({4-[(4-fluoro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 03 N-[(4-{[5-fluoro-2- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide 04 N-{[4-(1-methyl-1H-indole-2- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 05 N-({4-[(4-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide 06 N-({4-[(2,6-dichloro-3- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 07 N-({4-[(2,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6- carboxamide 08 N-({4-[(3- fluorobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 09 N-({4-[(4-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(6-methoxypyridine-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2,4,6- trimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(4-chloro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-({4-[(2- cyanobenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-[(4-{[2-fluoro-3-(propan-2- yloxy)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[4-(difluoromethyl)-3- fluorobenzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-(phenoxathiine-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2- (dimethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4-methoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-[4-(benzenesulfonyl)phenyl]pyridine-3- carboxamide N-({4-[(2-methyl-4- propoxybenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide 0 N-({4-[(3-ethoxy-4- fluorobenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-imidazo[4,5-c]pyridine-2-carboxamide N-[(4-{[2,4- bis(trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(6-methoxynaphthalene-2- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 3-(pyridin-4-yl)-1H-pyrazole-5- carboxamide N-({4-[(2- acetylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(4- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-{[4-(4-methylpyridine-2- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-({4-[(2-ethoxy-4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[(4-ethoxy-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]primidine-6-carboxamide N-({4-[(6-chloro-2-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(5-chloro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(furan-2- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2,6-dimethoxy-4- methylbenzene)sulfonyl]phenyl}meth- yl)furo[2,3-c]pyridine-2-carboxamide N-({4-[(2- phenylethane)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)thieno[2,3-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-4- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide 0 N-[(4-{[3-fluoro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-6- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- sulfonyl]phenyl}methyl)furo[2,3- c]pyridine-2-carboxamide N-({4-[(3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(morpholin-4- yl)benzene]sulfonyl}phenyl)methyl]-1,3- benzothiazole-6-carboxamide N-({4-[(3- ethoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrrolo[3,2-c]pyridine-2- carboxamide 0 N-({4-[(4-chloro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-({4-[(pyrrolidin-1- yl)carbonyl]benzene}sulfo- nyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3- (methoxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-5- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(4- cyanobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-({4-[(2- cyanobenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 5-N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}meth- yl)pyridine-2,5-diamido 0 N-({4-[(4-fluoro-3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1,6-naphthyridine-2-carboxamide N-({4-[(4-methoxy-3- methylbenzene)sulfonyl]phenyl}meth- yl(imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4- methanesulfonylbenzene)sulfo- nyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- cyanobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-methoxy-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6- carboxamide N-{[4-(2H-1,3-benzodioxole-5- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-fluoro-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(2,5- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(5-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- acetylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2-methyl-4- (trifluoromethyl)benzene]sulfo- nyl)phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(2-fluoro-6- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(quinoline-8- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-chloro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(2,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-fluoro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(2- ethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{8-oxatricyclo[7.4.0.0.sup.2,7]trideca- 1(13),2,4,6,9,11-hexaene-6- sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 6-amino-N-({4-[(3,5- difluorobenzene)sulfonyl]phenyl}meth- yl)pyridine-3-carboxamide N-({4-[(3-chloro-4- propoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[4-methoxy-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl))methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-fluoro-3- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-methoxy-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3- ethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4- ethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 00 N-[(4-{[4-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide 01 N-[(4-{[4-fluoro-2- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide 02 N-[(4-{[3- (cylcopentylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide 03 N-[(4-{[4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide 04 N-[(4-{[2-(morpholin-4- ylmethyl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyrimidine-6-carboxamide 05 N-({4-[(2- ethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 06 N-[(4-{[3-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide 07 N-({4-[(5-tert-butyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 08 N-({4-[(4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 09 N-({4-[(3,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-({4-[(2-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(phenoxathiine-4- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2- phenoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-(morpholin-4- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-methoxy-2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2-chloro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-pyrazole-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-ethoxy-4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5-carboxamide 0 N-({4-[(4,5-difluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,4- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2,4- difluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(5-methylthiophene-2- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[5-fluoro-2- (hydroxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[4- (ethylcarbamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-methoxy-3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-fluoro-5-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(3- propoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2,4,5- trimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(2-chloro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2,3,6- trimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-fluoro-2- methylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine- 5-carboxamide N-({4-[(3- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(5-acetyl-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-chloro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-chloro-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(2- phenoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(4- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[4-fluoro-3-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[4-fluoro-3- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2,4,5- trimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,3-difluoro-6- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-{[4-(quinoline-6- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-fluoro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2,4- bis(trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide 0 N-({4-[(3-fluoro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,3- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-methoxy-5- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-chloro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(4-chloro-3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4-(2- methylpropoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(3- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-fluoro-4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,4-dichloro-3- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(5-chloro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2,3- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2-butoxy-4- fluorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-((4-[(2,5- dimethoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,5- dichlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(1-methyl-1H-indazole-5- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide 0 N-({4-[(3-chloro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-fluoro-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3- fluorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[4- (ethoxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(4- phenylbutane)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-4- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4- cyanobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3- sulfamoylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2-(benzyloxy)-5- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-{[4-(napthalene-1- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H-pyrrolo[3,2-c]pyridine-3-carboxamide N-{[4-(1-methyl-1H-indazole-7- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-fluoro-2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-(2H-1,3-benzodioxole-4- sulfonyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-chloro-2- propoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(3-fluoro-2- methoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2-fluoro-5- methoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4-butoxy-2- methylbenzen)-sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[4-(propan-2- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2,3- dimethoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(3-fluoro-4- propoxybenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2- (methylsulfamoyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2-methoxy-5-(propan-2- yl)benzene]sulfonyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- yl)benzene]sulfonyl}phenyl)meth- yl]imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(2- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(6-chloro-2-fluoro-3- methylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-{[4-({4-fluoro-3-[(propan-2- yl)carbamoyl]benzene}sulfo- nyl)phenyl]methyl}-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(4- butylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2- ethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 00 N-({4-[(2,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 01 N-[(4-{[3- (methoxymethyl)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide 02 N-({4-[(2,5- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 03 N-[(4-{[5-chloro-2-(propan-2- yloxy)benzene]sulfonyl}phenyl)methyl]- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 04 N-({4-[(2-butoxy-5- chlorobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 05 N-({4-[(4-chloro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 06 N-({4-[(3- butoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 07 N-({4-[(3- acetylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 08 N-({4-[(3- phenylpropane)sulfonyl]phenyl}methyl)- 1H-pyrrolo[3,2-c]pyridine-2-carboxamide 09 N-({4-[(4- butoxybenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(2,6- dimethylbenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(2-chloro-6- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(4-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-fluoro-5-(2,2,2- trifluoroethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-({4-[(2-methoxy-5- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3-fluoro-4- methylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3,4- dimethylbenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{[2-methoxy-4- (trifluoromethyl)benzene]sulfo- nyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(2- chlorobenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[(3- cyanobenzene)sulfonyl]phenyl}methyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide 0 N-({4-[(2,4,6- trimethylbenzene)sulfonyl]phenyl}meth- yl)-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-fluoro-4- (trifluoromethoxy)benzene]sulfo- nyl}phenyl)methyl]-1H- pyrazolo[3,4-b]pyridine-5- carboxamide N-({4-[(5-fluoro-2- methoxybenzene)sulfonyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide N-(4-(3- (trifluoromethoxy)phenylsulfonyl)benzyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-(4-(3- (trifluoromethyl)phenylsulfonyl)benzyl)- 1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-(4-(3,5-difluorophenylsulfonyl)benzyl)- 1,8a-dihydroimidazo[1,2-a]pyridine-6- carboxamide 7,8-Dihydro-5H-pyrido[3,4-b]pyrazine-6- carboxylic acid 4-benzenesulfonyl- benzylamide 3,4-Dihydro-1H-[2,6]naphthyridine-2- carboxylic acid 4-benzenesulfonyl- benzylamide 3,4-Dihydro-1H-[2,7]naphthyridine-2- carboxylic acid 4-benzenesulfonyl- benzylamide 6,7-Dihydro-4H-isoxazolo[4,3-c]pyridine- 5-carboxylic acid 4-benzenesulfonyl- benzylamide 0 5,8-Dihydro-6H-[1,7]naphthyridine-7- carboxylic acid 4-benzenesulfonyl- benzylamide 6,7-Dihydro-4H-isoxazolo[4,5- c]pyridine-5-carboxylic acid 4-benzenesulfonyl- benzylamide 1,3-Dihydro-pyrrolo[3,4-c]pyridine-2- carboxylic acid 4-benzenesulfonyl- benzylamide Imidazo[1,2-a]pyrazine-6-carboxylic acid 4-benzenesulfonyl-benzylamide Imidazo[1,5-a]pyridine-6-carboxylic acid 4-benzenesulfonyl-benzylamide 1H-Pyrazolo[3,4-c]pyridine-5-carboxylic acid 4-benzenesulfonyl-benzylamide Imidazo[1,2-a]pyridine-7-carboxylic acid 4-(3,5-difluoro-benzenesulfonyl)- benzylamide 1H-Pyrazolo[4,3-b]pyridine-5-carboxylic acid 4-benzenesulfonyl-benzylamide Furo[3,2-b]pyridine-2-carboxylic acid 4- benzenesulfonyl-benzylamide N-{[4- (benzenesulfonyl)phenyl]methyl}thieno[3,2- b]pyridine-2-carboxamide 0 N-{[4- (benzenesulfonyl)phenyl]meth- yl}imidazo[1,5-a]pyridine-6- carboxamide N-{[5-(benzenesulfonyl)pyridin-2- yl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4- (benzenesulfonyl)phenyl]meth- yl}imidazo[1,2-a]pyrazine-6-carboxamide N-{[4- (benzenesulfonyl)phenyl]methyl}furo[3,2- b]pyridine-2-carboxamide N-{[6-(benzenesulfonyl)pyridin-3- yl]methyl}-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-{[4-(piperazine-1- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-(piperazine-1- sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-{[4-(3-aminopyrrolidine-1- sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide hydrochloride N-{[4-(3-aminopyrrolidine-1- sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide hydrochloride N-({4-[(3,5- difluorobenzene)sulfinyl]phenyl}meth- yl)imidazo[1,2-a]pyridine-6-carboxamide 0 N-{[4-(benzenesulfonyl)phenyl]methyl}- 5,6,7,8-tetrahydro-1,6-naphthyridine-6- carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 5H,6H,7H-pyrrolo[3,4-b]pyridine-6- carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H,4H,5H,6H,7H-pyrazolo[4,3- c]pyridine-5-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 5H,6H,7H,8H-pyrido[4,3-d]pyrimidine-6- carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 1H,4H,5H,6H,7H-imidazo[4,5-c]pyridine- 5-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}- 4H,5H,6H,7H-[1,2]oxazole[4,3- c]pyridine-5-carboxamide

EXAMPLES

(264) The following are illustrative, but non-limiting, examples of certain embodiments of the present invention.

(265) The invention is illustrated further by the following examples, which are not to be construed as limiting the invention in scope or spirit to the specific procedures described in them. Those having skill in the art will recognize that the starting materials may be varied and additional steps employed to produce compounds encompassed by the present inventions, as demonstrated by the following examples. In some cases, protection of certain reactive functionalities may be necessary to achieve some of the above transformations. In general, such need for protecting groups, as well as the conditions necessary to attach and remove such groups, will be apparent to those skilled in the art of organic synthesis.

(266) Compounds according to the invention may be synthesized by synthetic routes that include processes analogous to those well-known in the chemical arts, particularly in light of the description contained herein, and those for other heterocycles described in: Comprehensive Heterocyclic Chemistry II, Editors Katritzky and Rees, Elsevier, 1997, e.g. Volume 3; Liebigs Annalen der Chemie, (9):1910-16, (1985); Helvetica Chimica Acta, 41:1052-60, (1958); Arzneimittel-Forschung, 40(12):1328-31, (1990), each of which are expressly incorporated by reference. Starting materials are generally available from commercial sources such as Aldrich Chemicals (Milwaukee, Wis.) or are readily prepared using methods well known to those skilled in the art (e.g., prepared by methods generally described in Louis F. Fieser and Mary Fieser, Reagents for Organic Synthesis, v. 1-23, Wiley, N.Y. (1967-2006 ed.), or Beilsteins Handbuch der organischen Chemie, 4, Aufl. ed. Springer-Verlag, Berlin, including supplements (also available via the Beilstein online database).

(267) Synthetic chemistry transformations and protecting group methodologies (protection and deprotection) useful in synthesizing compounds according to the invention and necessary reagents and intermediates are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations, VCH Publishers (1989); T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 3rd Ed., John Wiley and Sons (1999); and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis, John Wiley and Sons (1995) and subsequent editions thereof.

(268) Compounds according to the invention may be prepared singly or as compound libraries comprising at least 2, for example 5 to 1,000 compounds, or 10 to 100 compounds. Libraries of compounds of Formula I may be prepared by a combinatorial ‘split and mix’ approach or by multiple parallel syntheses using either solution phase or solid phase chemistry, by procedures known to those skilled in the art. Thus according to a further aspect of the invention there is provided a compound library comprising at least 2 compounds, or pharmaceutically acceptable salts thereof.

(269) The General Procedures and Examples provide exemplary methods for preparing compounds according to the invention. Those skilled in the art will appreciate that other synthetic routes may be used to synthesize the compounds according to the invention. Although specific starting materials and reagents are depicted and discussed in the schemes, General Procedures, and Examples, other starting materials and reagents can be easily substituted to provide a variety of derivatives and/or reaction conditions. In addition, many of the exemplary compounds prepared by the described methods can be further modified in light of this disclosure using conventional chemistry well known to those skilled in the art.

(270) In preparing compounds according to the invention, protection of remote functionality (e.g., primary or secondary amine) of intermediates may be necessary. The need for such protection will vary depending on the nature of the remote functionality and the conditions of the preparation methods. Suitable amino-protecting groups include acetyl, trifluoroacetyl, t-butoxycarbonyl (BOC), benzyloxycarbonyl (CBz) and 9-fluorenylmethyleneoxycarbonyl (Fmoc). The need for such protection is readily determined by one skilled in the art. For a general description of protecting groups and their use, see T. W. Greene, Protective Groups in Organic Synthesis, John Wiley & Sons, New York, 1991.

(271) In the methods of preparing compounds according to the invention, it may be advantageous to separate reaction products from one another and/or from starting materials. The desired products of each step or series of steps is separated and/or purified to the desired degree of homogeneity by the techniques common in the art. Typically such separations involve multiphase extraction, crystallization from a solvent or solvent mixture, distillation, sublimation, or chromatography. Chromatography can involve any number of methods including, for example: reverse-phase and normal phase; size exclusion; ion exchange; high, medium and low pressure liquid chromatography methods and apparatus; small scale analytical; simulated moving bed (SMB) and preparative thin or thick layer chromatography, as well as techniques of small scale thin layer and flash chromatography.

(272) Another class of separation methods involves treatment of a mixture with a reagent selected to bind to or render otherwise separable a desired product, unreacted starting material, reaction by product, or the like. Such reagents include adsorbents or absorbents such as activated carbon, molecular sieves, ion exchange media, or the like. Alternatively, the reagents can be acids in the case of a basic material, bases in the case of an acidic material, binding reagents such as antibodies, binding proteins, selective chelators such as crown ethers, liquid/liquid ion extraction reagents (LIX), or the like. Selection of appropriate methods of separation depends on the nature of the materials involved, such as, boiling point and molecular weight in distillation and sublimation, presence or absence of polar functional groups in chromatography, stability of materials in acidic and basic media in multiphase extraction, and the like.

(273) Diastercomeric mixtures can be separated into their individual diastereomers on the basis of their physical chemical differences by methods well known to those skilled in the art, such as by chromatography and/or fractional crystallization. Enantiomers can be separated by converting the enantiomeric mixture into a diastereomeric mixture by reaction with an appropriate optically active compound (e.g., chiral auxiliary such as a chiral alcohol or Mosher's acid chloride), separating the diastereomers and converting (e.g., hydrolyzing) the individual diastereoisomers to the corresponding pure enantiomers. Also, some of the compounds of the present invention may be atropisomers (e.g., substituted biaryls) and are considered as part of this invention. Enantiomers can also be separated by use of a chiral HPLC column.

(274) A single stereoisomer, e.g., an enantiomer, substantially free of its stereoisomer may be obtained by resolution of the racemic mixture using a method such as formation of diastereomers using optically active resolving agents (Eliel, E. and Wilen, S. “Stereochemistry of Organic Compounds,” John Wiley & Sons, Inc., New York, 1994; Lochmuller, C. H., (1975) J. Chromatogr., 113(3):283-302). Racemic mixtures of chiral compounds of the invention can be separated and isolated by any suitable method, including: (1) formation of ionic, diastereomeric salts with chiral compounds and separation by fractional crystallization or other methods, (2) formation of diastereomeric compounds with chiral derivatizing reagents, separation of the diastereomers, and conversion to the pure stereoisomers, and (3) separation of the substantially pure or enriched stereoisomers directly under chiral conditions. See: “Drug Stereochemistry, Analytical Methods and Pharmacology,” Irving W. Wainer, Ed., Marcel Dekker, Inc., New York (1993).

(275) Under method (1), diastereomeric salts can be formed by reaction of enantiomerically pure chiral bases such as brucine, quinine, ephedrine, strychnine, a-methyl-b-phenylethylamine (amphetamine), and the like with asymmetric compounds bearing acidic functionality, such as carboxylic acid and sulfonic acid. The diastereomeric salts may be induced to separate by fractional crystallization or ionic chromatography. For separation of the optical isomers of amino compounds, addition of chiral carboxylic or sulfonic acids, such as camphorsulfonic acid, tartaric acid, mandelic acid, or lactic acid can result in formation of the diastereomeric salts.

(276) Alternatively, by method (2), the substrate to be resolved is reacted with one enantiomer of a chiral compound to form a diastereomeric pair (E. and Wilen, S. “Stereochemistry of Organic Compounds”, John Wiley & Sons, Inc., 1994, p. 322). Diastereomeric compounds can be formed by reacting asymmetric compounds with enantiomerically pure chiral derivatizing reagents, such as menthyl derivatives, followed by separation of the diastereomers and hydrolysis to yield the pure or enriched enantiomer. A method of determining optical purity involves making chiral esters, such as a menthyl ester, e.g., (-) menthyl chloroformate in the presence of base, or Mosher ester, a-methoxy-a-(trifluoromethyl)phenyl acetate of the racemic mixture and analyzing the 1H NMR spectrum for the presence of the two atropisomeric enantiomers or diastereomers (Jacob III. J. Org. Chem. (1982) 47:4165). Stable diastereomers of atropisomeric compounds can be separated and isolated by normal- and reverse-phase chromatography following methods for separation of atropisomeric naphthyl-isoquinolines (WO 96/15111). By method (3), a racemic mixture of two enantiomers can be separated by chromatography using a chiral stationary phase (“Chiral Liquid Chromatography” (1989) W. J. Lough, Ed., Chapman and Hall, New York; Okamoto, J. Chromatogr., (1990) 513:375-378). Enriched or purified enantiomers can be distinguished by methods used to distinguish other chiral molecules with asymmetric carbon atoms, such as optical rotation and circular dichroism.

(277) Definitions Used in the Following Schemes and Elsewhere Herein are:

(278) BOP ammonium 4-(3-(pyridin-3-methyl)ureido)benzenesulfinate CDCl.sub.3 deuterated chloroform δ chemical shift (ppm) DCM dichloromethane or methylene chloride DIEA N,N-diisopropylethylamine DMA N,N-dimethylacetamide DMF N,N-dimethylformamide DMSO dimethylsulfoxide DMSO-d.sub.6 deuterated dimethylsulfoxide EDCl N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride EtOAc ethyl acetate EtOH ethanol GF/F glass microfiber filter H NMR proton nuclear magnetic resonance HOAc acetic acid HATU 2-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethylisouronium hexafluorophosphate HOBT 1H-benzo[d][1,2,3]triazol-1-ol hydrate HPLC high pressure liquid chromatography MHz megahertz KOAc potassium acetate i-PrOH isopropanol LC-MS liquid chromatography/mass spectrometry (M+1) mass+1 m-CPBA m-chloroperbenzoic acid MeOH methanol N.sub.2 nitrogen NaHCO.sub.3 sodium bicarbonate MgSO.sub.4 magnesium sulfate PTLC preparative thin layer chromatography TEA triethylamine THF tetrahydrofuran TLC thin layer chromatography
Amide-Sulfonamide:

(279) ##STR01556##

(280) In Scheme 1, compound III can be obtained by treating II with I (G=OH) in the presence of a coupling reagent such as EDCI, HATU, or HOBt, and a base (e.g.: K.sub.2CO.sub.3, Cs.sub.2CO.sub.3, NR.sub.1R.sub.2R.sub.3, NaOR, KOR) in an inert solvent such as dichloromethane, N,N-dialkylformamide, N,N-dialkylacetamidc, dialkylethers, cyclic ethers, DMSO, N-methyl-2-pyrrolidinone at temperatures ranging from −78° C. to 200° C. Alternatively, compound I can be treated with I (G=OR) in the presence of trimethylaluminum in an inert solvent (such as toluene) at temperatures ranging from −78° C. to 200° C.

(281) Those having skill in the art will recognize that the starting materials may be varied and additional steps employed to produce compounds encompassed by the present inventions, as demonstrated by the following examples. Unless otherwise specified, all reagents and solvents were of standard commercial grade and were used without further purification.

(282) Amide Sulfone:

(283) ##STR01557##

(284) Compound III of scheme 2 can be obtained by treating II with I (G=OH) in the presence of a coupling reagent such as EDCI, HATU, BOP, or HOBt, and a base (eg: K.sub.2CO.sub.3, Cs.sub.2CO.sub.3, NR.sub.1R.sub.2R.sub.3, NaOR, KOR) in an inert solvent such as dichloromethane, N,N-dialkylformamide, N,N-dialkylacetamide, dialkylethers, DMSO, or N-methyl-2-pyrrolidinone at temperatures ranging from −78° C. to 200° C. Alternatively, compound 111 can be obtained by treating 1 (G=OR) with I and trimethylaluminum in an inert solvent (such as toluene) at temperatures ranging from −78° C. to 200° C.

(285) Those having skill in the art will recognize that the starting materials may be varied and additional steps employed to produce compounds encompassed by the present inventions, as demonstrated by the following examples. Unless otherwise specified all reagents and solvent are of standard commercial grade and are used without further purification.

(286) ##STR01558##

(287) In Scheme 3, the compound of III present invention can also be synthesized by following the steps outlined in Scheme IV. Treating II with IV in the presence of a coupling reagent such as EDCI, HATU, BOP, or HOBt, and a base (eg: K.sub.2CO.sub.3, Cs.sub.2CO.sub.3, NR.sub.1R.sub.2R.sub.3, NaOR, KOR) in an inert solvent such as dichloromethane, N,N-dialkylformamide, N,N-dialkylacetamide, dialkylethers, DMSO, or N-methyl-2-pyrrolidinone at temperatures ranging from −78° C. to 200° C. gives compound V. Compound V can be treated with a base such as sodium ethoxide in the present of a protonated solvent such as ethanol to afford compound VI. Treating compound VI with arylboronic acid or aryl halogens facilitated by palladium or copper to obtain the target compound 111.

Example 1 Preparation of Representative Amide-Sulfonamide Analogues

(288) These examples illustrate the preparation of representative substituted amide-sulfonamide analogues.

Example 1A

N-(4-(N-(2-(trifluoromethoxy)phenyl)sulfamoyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(289) ##STR01559##

A: 4-cyano-N-(2-(trifluoromethoxy)phenyl)benzenesulfonamide

(290) ##STR01560##

(291) 2-(Trifluoromethoxy)aniline (10.902 g, 58.5 mmol) was dissolved in pyridine (100 mL) and cooled to 0° C. A solution of 4-cyanobenzene-1-sulfonyl chloride (11.573 g, 55.7 mmol) was added in pyridine (100 mL) over 10 minutes via addition funnel. The mixture was heated to 85° C. for 16 hours and the pyridine was removed under reduced pressure. The residue was diluted with DCM and washed with 1M HCl (×2), water (×1), brine (×1), and saturated NaHCO.sub.3 (×1). The organic layer was dried over anhydrous MgSO.sub.4, filtered, concentrated, and purified by Biotage SP1 (hexanes/DCM) to afford the title compound as a white solid.

(292) .sup.1H NMR (300 HMz; DMSO-d.sub.6): δ 10.58 (s, 1H), 8.06 (d, 2H), 7.89 (d, 2H), 7.30 (s, 4H).

B: 4-(aminomethyl)-N-(2-(trifluoromethoxy)phenyl)benzenesulfonamide

(293) ##STR01561##

(294) 4-Cyano-N-(2-(trifluoromethoxy)phenyl)benzenesulfonamide (2.0 g, 5.84 mmol) was dissolved in THF (30 mL) and borane tetrahydrofuran complex (14.61 mL of a 1M solution in THF) was added. The mixture was heated to 70° C. for 2 hours, then cooled to room temperature followed by the addition of MeOH (10 mL). The mixture was briefly warmed to 70° C. for 15 minutes, then the volatiles removed under reduced pressure and EtOAc (100 mL) and 1N NaOH (50 mL) were added to the residue. The layers were separated, and the organic layer washed with water and brine. The combined aqueous washes were extracted with EtOAc, combined with the previous organic extracts, and dried over MgSO.sub.4. The residue was purified by Biotage SP1 (McOH/DCM/NH.sub.3 gradient) to afford the title compound as a pale yellow solid.

(295) .sup.1H NMR (300 HMz; DMSO-d.sub.6): δ 7.70 (d, 2H), 7.41 (d, 2H), 7.19 (d, 1H), 7.00 (d, 1H), 6.89 (t, 1H), 6.58 (t, 1H), 3.84 (s, 2H).

C: N-(4-(N-(2-(trifluoromethoxy)phenyl)sulfamoyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(296) ##STR01562##

(297) A mixture of 1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (478 mg, 2.95 mmol), 4-(aminomethyl)-N-(2-(trifluoromethoxy)phenyl)benzenesulfonamide (973 mg, 2.81 mmol), HATU (1.122 g, 2.95 mmol), DIEA (1.082 mL, 6.20 mmol), and DMF (15 mL) at 25° C. were stirred for 16 hours at ambient temperature. The mixture was diluted with EtOAc and washed successively with saturated NaHCO.sub.3 and brine. The organic extracts were separated and dried over MgSO.sub.4, filtered, concentrated, and purified by Biotage SP1 (DCM/MeOH gradient). The combined fractions were triturated with Et.sub.2O to afford the product as a white solid.

(298) .sup.1H NMR (300 HMz; DMSO-d.sub.6): δ 12.10 (br s, 1H), 9.23 (t, 1H), 8.98 (s, 1H), 8.21 (d, 1H), 7.78 (d, 2H), 7.47 (d, 2H), 7.38 (d, 1H), 7.31-7.19 (m, 6H), 4.58 (d, 2H). LC-MS: 491.11 (M+1).

Example 1B

N-(4-(piperidin-1-ylsulfonyl)benzyl)thieno[3,2-c]pyridine-2-carboxamide

(299) ##STR01563##

(300) (4-(Piperidin-1-ylsulfonyl)phenyl)methanamine (155 mg, 0.609 mmol) and trimethylaluminum (0.30 mL, 0.600 mmol) were combined in toluene (2 mL) and stirred for 30 minutes at ambient temperature. A solution of methyl thieno[3,2-c]pyridine-2-carboxylate (100 mg, 0.518 mmol, prepared according to WO 2004/064836) in toluene (2 mL) was then added and the mixture heated to 110° C. for 16 hours. Upon cooling, a saturated solution of potassium sodium tartrate and EtOAc were added and the mixture stirred vigorously for 30 minutes and then filtered. The layers were separated, the organics dried over MgSO.sub.4, and purified by Biotage SP1 (100% EtOAc) to afford the title compound as white foam.

(301) .sup.1H NMR (300 HMz; CDCl.sub.3): δ 9.13 (s, 1H), 8.50 (d, 1H), 7.93 (s, 1H), 7.79 (t, 1H), 7.67 (d, 1H), 7.48 (d, 2H), 7.36 (d, 2H), 4.69 (d, 2H), 2.89 (t, 4H), 1.63-1.55 (m, 4H), 1.42-1.34 (m, 2H) LC-MS: 416.11 (M+1).

Example IC

N-(4-(N-(2,5-dimethoxyphenyl)sulfamoyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(302) ##STR01564##

A: N-(4-(N-(2,5-dimethoxyphenyl)sulfamoyl)benzyl)acetamide

(303) ##STR01565##

(304) A mixture of 4-(acetamidomethyl)benzene-1-sulfonyl chloride (25 mg, 0.1 mmol), 2,5-dimethoxyaniline (15.3 mg, 0.1 mmol), and pyridine (0.25 mL) in DMA (1 mL) were heated at 50° C. for 16 hours before being concentrated under reduced pressure. The residue was purified by PTLC (100% EtOAc) to afford the title compound as white solid.

(305) .sup.1H NMR (400 HMz; CDCl.sub.3): δ 7.73 (d, J=8 Hz, 2H), 7.30 (d, J=8 Hz, 2H), 7.14 (d, J=3.2 Hz, 1H), 7.05 (s, 1H), 6.66 (d, J=8.8 Hz, 1H), 6.54 (dd, J=8.8 Hz, J′=3.2 Hz, 1H), 5.95 (br s, 1H), 4.46 (d, J=6 Hz, 2H), 3.74 (s, 3H), 3.61 (s, 3H), 2.07 (s, 3H). LC-MS: 364.99 (M+1).

B: (4-(N-(2,5-dimethoxyphenyl)sulfamoyl)phenyl)methanaminium Chloride

(306) ##STR01566##

(307) A mixture of N-(4-(N-(2,5-dimethoxyphenyl)sulfamoyl)benzyl)acetamide (28 mg, 0.077 mmol) and 3N HCl (0.5 mL, 1.5 mmol) in 70% i-PrOH (0.5 mL) was heated at 100° C. for 5 hours. The mixture was concentrated to dryness in vacuo to afford the title compound as off-white solid.

(308) .sup.1H NMR (400 HMz; CDCl.sub.3): δ 7.84 (d, J=8.4 Hz, 2H), 7.56 (d, J=8.8 Hz, 2H), 7.04 (d, J=2.8 Hz, 1H), 6.74 (d, J=9.2 Hz, 1H), 6.60 (dd, J=9.2 Hz, J′=3.2 Hz, 1H), 5.95 (br s, 1H), 4.16 (s, 2H), 3.70 (s, 3H), 3.54 (s, 3H). LC-MS: 323.03 (M+1)

C: N-(4-(N-(2,5-dimethoxyphenyl)sulfamoyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(309) ##STR01567##

(310) The title compound was prepared following Example 1C, substituting BOP in place of HATU, and 4-(aminomethyl)-N-(2,5-dimethoxyphenyl)benzenesulfonamide in place of 4-(aminomethyl)-N-(2-(trifluoromethoxy)phenyl)benzenesulfonamide. The product was purified by PTLC.

(311) .sup.1H NMR (400 HMz; CD.sub.3OD): δ 8.90 (d, J=0.8 Hz, 1H), 8.22 (d, J=5.6 Hz, 1H), 7.71 (d, J=8.4 Hz, 2H), 7.51 (d, J=6 Hz, 1H), 7.45 (d, J=8.8 Hz, 2H), 7.28 (d, J=0.8 Hz, 1H), 7.02 (d, J=3.2 Hz, 1H), 6.70 (d, J=9.2 Hz, 1H), 6.59 (dd, J=8.8 Hz, J′=3.2 Hz, 1H), 4.62 (s, 2H), 3.69 (s, 3H), 3.46 (s, 3H). LC-MS: 466.98 (M+1).

Example 2: Preparation of Representative Amide-Sulfone Analogues

(312) These examples illustrate the preparation of representative substituted amide-sulfonamide analogues.

Example 2 A

N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(313) ##STR01568##

a: 4-(phenylsulfonyl) Benzonitrile

(314) ##STR01569##

(315) A mixture of 4-fluorobenzonitrile (5 g, 41.3 mmol) and sodium benzenesulfinate (7.45 g, 45.4 mmol) in DMSO (30 mL) was heated at 130° C. for 16 hours. The mixture was cooled to room temperature and poured onto 300 g of ice. The precipitate was collected, washed with water, and dried to afford the title compound.

(316) .sup.1H NMR (300 MHz, CDCl.sub.3): δ 8.03-8.07 (m, 2H), 7.93-7.97 (m, 2H), 7.78-7.82 (m, 2H), 7.60 (m7.65, 1H), 7.26-7.58 (m, 2H)

b: (4-[phenylsulfonyl] phenyl) Methanamine

(317) ##STR01570##

(318) A mixture of 4-(phenylsulfonyl) benzonitrile (9.4 g, 38.64 mmol) and Raney Ni (500 mg) in 2N NH.sub.3-MeOH (150 mL) was hydrogenated for 16 hours at 50 psi. Nitrogen gas was bubbled through the mixture, which was then filtered through a short Celite pad, and washed with methanol. The filtrate was concentrated and triturated with ether to afford the title compound.

(319) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 7.85-7.95 (m, 4H), 7.53-7.68 (m, 5H), 3.74 (s, 2H), 1.83 (br s, 2H)

c: N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(320) ##STR01571##

(321) A mixture of 1H-pyrrolo[3,2-2]pyridine-2-carboxlic acid (1.0 g, 6.17 mmol), HATU (3.52 g, 9.25 mmol), diisopropylethylamine (2.69 mL, 15.42 mmol), and (4-(phenylsulfonyl)phenyl)methanamine (1.754 g, 7.09 mmol) in DMF (70 mL) was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, water (200 mL) was added, and the mixture was extracted with EtOAc (3×300 mL). The combined organic layers were successively washed with water, saturated sodium bicarbonate, and brine. The extracts were dried with sodium sulfate, concentrated in vacuo, and purified by Biotage with MeOH/DCM (0%-10%) to afford the title compound.

(322) .sup.1H NMR (300 MHz, DMSO-d.sub.6) 4.56 (d, J=5.57 Hz, 2H), 7.29 (s, 1H), 7.34 (d, J=5.57 Hz, 1H), 7.56-7.66 (m, 5H), 7.91-7.94 (m, 4H), 8.20 (d, J=5.87 Hz, 1H), 8.91 (s, 1H), 9.245-9.28 (m, 1H). 12.03 (s, 1H) LC-MS: 392.13 (M+1).

Example 2 B

3-bromo-N-(4-(phenylsulfonyl)benzyl)-1H-Pyrrolo[3,2-c]pyridine-2-carboxamide

(323) ##STR01572##

(324) A mixture of N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide (from Example 1; 200 mg, 0.511 mmol) and 1-bromopyrrolidine-2,5-dione (91 mg, 0.511 mmol) in DMF (10 mL) was stirred at room temperature for 16 hours. EtOAc (100 mL) was added to the mixture. The organic layer was washed with water and brine, dried with sodium sulfate, and concentrated in vacuo. The crude was purified by Biotage with McOH/DCM (0%-10%) to afford the title compound.

(325) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 12.42 (br s, 1H), 8.78 (m, 2H), 8.30 (d, 1H), 7.93 (d, 4H), 7.59-7.69 (m, 5H), 7.38 (dd, 1H), 4.59 (d, 2H) LC-MS: 470.06 (M+1).

Example 2 C

N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide

(326) ##STR01573##

a: 4-(4-fluorophenylsulfonyl) benzonitrile

(327) ##STR01574##

(328) The title compound was prepared following Example 1A, substituting sodium 4-fluorobenzenesulfonate for sodium benzenesulfinate.

(329) .sup.1H NMR (300 MHz, DMSO-D.sub.6) δ: 8.10-8.18 (m, 6H), 7.42-7.12 (t, 2H).

b: (4-[4-fluorophenylsulfonyl] Phenyl) Methanamine

(330) ##STR01575##

(331) The title compound was prepared following Example 1B, substituting 4-(4-fluorophenylsulfonyl)benzonitrile for 4-(phenylsulfonyl)benzonitrile.

(332) .sup.1H NMR (300 MHz, (DMSO-d.sub.6): δ 7.8-7.96 (m, 4H), 3.74 (s, 2H), 7.42-7.64 (m, 4H), 3.64 (m, 2H).

c: N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide

(333) ##STR01576##

(334) (4-(4-Fluorophenylsulfonyl)phenyl)methanamine hydrochloride (1409 mg, 4.67 mmol) was mixed with toluene (20 mL) and cooled to 0° C. Trimethylaluminum (7.00 mL of a 2M solution in toluene) was added and the mixture was stirred for 40 minutes at ambient temperature. A solution of methyl thieno[2,3-c]pyridine-2-carboxylate (820 mg, 4.24 mmol, prepared according to WO 2004/064836) in toluene (10 mL) was added via syringe, and the mixture was heated to 80° C. for 4 hours. The mixture was diluted with saturated potassium sodium tartrate (25 mL) and EtOAc (25 mL), stirred vigorously for 1 hour, and then filtered through GF/F paper. The organic layer was separated, dried over MgSO.sub.4, filtered, and concentrated to a yellow solid. The residue was triturated with DCM and the title compound was collected by vacuum filtration.

(335) .sup.1H NMR (300 MHz, DMSO-d.sub.6) δ 9.59 (t, 1H), 9.30 (s, 1H), 9.50 (d, 1H), 8.15 (s, 1H), 8.04-7.98 (m, 2H), 7.96-7.90 (m, 3H), 7.56 (d, 2H), 7.47-7.40 (m, 2H), 4.55 (d, 2H) LC-MS: 427.03 (M+1).

Example 2 D

N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(336) ##STR01577##

a: sodium 4-(acetamidomethyl)benzenesulfinate

(337) ##STR01578##

(338) 4-(Acetamidomethyl)benzene-1-sulfonyl chloride (1.24 g, 5 mmol) was added to a water-cooled solution of Na.sub.2SO.sub.3 (1.89 g, 15 mmol) in water (3.75 mL) then solid NaHCO.sub.3 (850 mg, 10 mmol) was added in several small portions to keep the pH slightly basic. The mixture was stirred at ambient temperature for 2 hours, affording a thick white suspension. Brine (2 ml) was added and the mixture was stirred at ambient temperature for 15 minutes. The precipitate was collected by filtration and dried overnight under vacuum. The solid was ground up and stirred with 125 ml of MeOH for 30 min then the solid was filtered off, washing with MeOH (20 mL). The filtrate was concentrated to give the title compound as a white solid.

(339) .sup.1H NMR (400 MHz, CD.sub.3OD): δ 7.61 (d, J=8.4 Hz, 2H), 7.34 (d, J=8.4 Hz, 2H), 4.38 (s, 2H), 1.98 (s, 3H).

b: N-(4-(benzo[d][1,3]dioxol-5-ylsulfonyl)benzyl)acetamide

(340) ##STR01579##

(341) A mixture of sodium 4-(acetamidomethyl)benzenesulfinate (23.5 mg, 0.1 mmol), benzo[d][1,3]dioxol-5-ylboronic acid (20.7 mg, 0.125 mmol), copper(II) acetate (22.7 mg, 0.125 mmol), and TEA (0.063 mL, 0.45 mmol) in DMSO (1.5 mL) was heated at 60° C. for 16 hours. The mixture was cooled to room temperature and partitioned between EtOAc-brine. The organic layer was separated and concentrated in vacuo. The crude was purified by PTLC (100% EtOAc) to afford the title compound as white solid.

(342) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 7.85 (d, J=8 Hz, 2H), 7.52 (dd, J=8 Hz, J′=1.6 Hz, 1H), 7.39 (d, J=8.4 Hz, 2H), 7.29 (d, J=2 Hz, 1H), 6.87 (d, J=8 Hz, 1H), 6.05 (s, 2H), 5.87 (br s, 1H), 4.47 (d, J=6.4 Hz, 2H), 2.04 (s, 3H).

(343) LC-MS: 333.97 (M+1)

c: (4-(benzo[d][1,3]dioxol-5-ylsulfonyl)phenyl)methanamine hydrochloride

(344) ##STR01580##

(345) A mixture of N-(4-(benzo[d][1,3]dioxol-5-ylsulfonyl)benzyl)acetamide (10 mg, 0.03 mmol) and 3N HCl (0.36 mL, 1.08 mmol) in 70% i-PrOH (0.2 mL) was heated at 100° C. for 5 hours. The mixture was concentrated to dryness to afford the title compound as off-white solid.

(346) .sup.1H NMR (400 MHz, CD.sub.3OD): δ 8.00 (d, J=8.4 Hz, 2H), 7.64 (d, J=8.4 Hz, 2H), 7.55 (dd, J=8.4 Hz, J′=2 Hz, 1H), 7.34 (d, J=2.4 Hz, 1H), 6.98 (d, J=8 Hz, 1H), 6.08 (s, 2H), 4.19 (s, 2H).

(347) LC-MS: 219.99 (M+1)

d: N-(4-(phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(348) ##STR01581##

(349) The title compound was prepared following Example 1C, substituting (4-(benzo[d][1,3]dioxol-5-ylsulfonyl)phenyl)methanamine hydrochloride for (4-(phenylsulfonyl)phenyl)methanamine, and substituting BOP instead of HATU. The title compound was purified by PTLC.

(350) .sup.1H NMR (400 MHz, CD.sub.3OD): δ 9.05 (s, 1H), 8.29 (d, J=6 Hz, 1H), 7.90 (d, J=8.4 Hz, 2H), 7.68 (d, J=6 Hz, 1H), 7.57 (d, J=8 Hz, 2H), 7.52 (dd, J=8 Hz, J′=2 Hz, 1H), 7.42 (s, 1H), 7.31 (d, J=2 Hz, 1H), 6.95 (d, J=8.4 Hz, 1H), 6.06 (s, 2H), 4.66 (s, 2H) LC-MS: 435.97 (M+1).

Example 2 E

1-methyl-N-(4-(phenylsulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

(351) ##STR01582##

(352) Iodomethane (33.5 μL, 0.535 mmol) was added to a mixture of N-(4-(phenylsulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide (Example 12; 100 mg, 0.255 mmol) and potassium carbonate (106 mg, 0.764 mmol) in DMF (1 mL) at room temperature. The reaction mixture was heated to 60° C. for 16 hours, whereupon the mixture was diluted with EtOAc and washed with brine (×3). The organic layer was dried over Na.sub.2SO.sub.4 and concentrated in vacuo. The residue was dissolved in DMSO (2 mL) and purified via HPLC to afford the title compound.

(353) .sup.1H NMR (DMSO-d.sub.6): δ 9.31 (t, 1H), 9.02 (d, 1H), 8.72 (d, 1H), 8.28 (s, 1H), 7.94-7.90 (m, 4H), 7.66-7.55 (m, 5H), 4.56 (d, 2H), 4.07 (s, 3H). LC-MS: 407.07 (M+1).

Example 2 F

1-methyl-N-(4-(Phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(354) ##STR01583##

a: methyl 1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

(355) ##STR01584##

(356) Sodium hydride (48 mg (60%), 1.226 mmol) was added to a icc-cold solution of 1H-pyrrolo[3,2-c]pyridine-2-carboxylate 9180 mg, 1.022 mmol) in THF (3 mL). The mixture was then warmed to room temperature over 10 minutes. Iodomethane (0.070 mL, 1.124 mmol) was added and the mixture stirred for 16 hours. The mixture was partitioned between EtOAc and water. The combined organic layers were dried over MgSO.sub.4, filtered, and concentrated to dryness. The residue was purified by Biotage to afford the title compound.

(357) .sup.1H NMR (CDCl.sub.3): δ 8.90 (s, 1H), 8.35 (d, 1H), 7.92 (s, 1H), 7.20 (d, 1H), 3.95 (s, 3H), 3.82 (s, 3H).

b: 1-methyl-N-(4-(Phenylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(358) ##STR01585##

(359) The title compound was prepared following Example 3C, substituting methyl 1-methyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylate and (4-(phenylsulfonyl)phenyl)methanamine for methyl thieno[2,3-c]pyridine-2-carboxylate and (4-(4-fluorophenylsulfonyl)phenyl)methanamine, respectively. The title compound was purified by PTLC.

(360) .sup.1H NMR (DMSO-D.sub.6): δ 9.27 (t, 1H), 8.91 (s, 1H), 8.28 (d, 1H), 7.92-7.95 (m, 4H). 7.53-7.67 (m, 6H), 7.27 (s, 1H), 4.52 (d, 2H), 3.95 (s, 3H). LC-MS: 406.01 (M+1).

Example 2 G

N-(4-(phenylsulfonyl)benzyl)-1H-imidazo[4,5-c]pyridine-2-carboxamide

(361) ##STR01586##

a: methyl 1H-imidazo[4,5-c]pyridine-2-carboxylate

(362) ##STR01587##

(363) Methyl 2,2-dichloro-2-methoxyacetate (1.585 g, 9.16 mmol) was added to a solution of pyridine-3,4-diamine (0.5 g, 4.58 mmol) and DIEA (4.80 mL, 27.5 mmol) in DCM (20 mL). The mixture was stirred at room temperature for 16 hours, whereupon EtOAc was added and the mixture washed with saturated sodium bicarbonate and brine. The organic layer was dried over MgSO.sub.4, filtered, concentrated, and purified by Biotage to afford the title compound.

(364) .sup.1H NMR (CD.sub.3OD): δ 8.71 (s, 1H), 8.32 (d, 1H), 7.22 (d, 1H), 4.09 (s, 3H).

b: N-(4-(phenylsulfonyl)benzyl)-1H-imidazo[4,5-c]pyridine-2-carboxamide

(365) ##STR01588##

(366) The title compound was prepared following Example 3C, substituting methyl 1H-imidazo[4,5-c]pyridine-2-carboxylate and (4-(phenylsulfonyl)phenyl)methanamine for methyl thieno[2,3-c]pyridine-2-carboxylate and (4-(4-fluorophenylsulfonyl)phenyl)methanamine, respectively. The title compound was purified by PTLC. .sup.1H NMR (CD.sub.3OD): δ 8.32 (s, 1H), 8.16 (d, 1H), 7.89-7.93 (m, 4H), 7.51-7.64 (m, 5H), 7.30 (d, 1H), 4.81 (s, 2H).

(367) LC-MS: 393.02 (M+1).

Example 2 H

N-(4-((3-chloro-5-fluorophenyl)sulfonyl)benzyl)furo[2,3-c]pyridine-2-carboxamide

(368) ##STR01589##

a: ethyl furo[2,3-c]pyridine-2-carboxylate

(369) ##STR01590##

(370) To a solution of ethyl 3-(trifluoromethylsulfonyloxy)furo[2,3-c]pyridine-2-carboxylate (524 mg, 1.545 mmol, prepared according to US 20070049603) in ethanol (15 mL) was added 10% Pd/C (50 mg) and triethylamine (0.5 mL, 3.59 mmol). The mixture was placed under an atmosphere of hydrogen (balloon) and stirred for 16 hours. The mixture was filtered, concentrated, and purified by silica gel chromatography to afford the title compound as an off-white solid (278 mg, 94%).

(371) .sup.1H NMR (CDCl.sub.3): δ 9.03 (s, 1H), 8.51 (d, 1H), 7.63 (dd, 1H), 7.52 (d, 1H), 4.48 (q, 2H), 1.45 (t, 3H).

(372) MS (ESI): 192.01 (M+H).

b: furo[2,3-c]pyridine-2-carboxylic Acid

(373) ##STR01591##

(374) To a solution of ethyl furo[2,3-c]pyridine-2-carboxylate (3.82 g, 19.98 mmol) in water:THF:MeOH (1:1:1, 60 mL) was added potassium hydroxide (3.36 g, 59.9 mmol) and the resulting mixture was stirred at ambient temperature for 16 hours. The solvent volume was then reduced to ˜20 mL and acetic acid was added until pH ˜4. The solids were collected by vacuum filtration, washed twice with water, and dried in a vacuum oven overnight to afford the title compound (2.90 g, 89%).

(375) .sup.1H NMR (DMSO-d.sub.6): δ 9.09 (s, 1H), 8.47 (d, 1H), 7.81 (dd, 1H), 7.71 (d, 1H), 3.36 (br s, 1H).

c: N-(4-((3-chloro-5-fluorophenyl)sulfonyl)benzyl)furo[2,3-c]pyridine-2-carboxamide

(376) ##STR01592##

(377) To a mixture of furo[2,3-c]pyridine-2-carboxylic acid (243 mg, 1.487 mmol), (4-(3-chloro-5-fluorophenylsulfonyl)phenyl)methanamine hydrochloride (500 mg, 1.487 mmol), and (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (724 mg, 1.636 mmol) in DMF (8 mL) was added N,N-diisopropylethylamine (0.571 mL, 3.27 mmol). The homogeneous reaction mixture was stirred for 16 hours at ambient temperature, then the DMF was removed under reduced pressure. The residue was treated with EtOAc (10 mL) and 1N NaOH (5 mL) and the mixture was stirred vigorously until a precipitate emerged. The solids were collected by vacuum filtration, rinsing with water and EtOAc, to afford the title compound (440 mg, 67%).

(378) .sup.1H NMR (DMSO-d.sub.6): δ 9.62 (t, 1H), 9.03 (s, 1H), 8.46 (d, 1H), 8.02 (dt, 2H), 7.87-7.80 (m, 4H), 7.62 (d, 1H), 7.58 (d, 2H), 4.56 (d, 2H).

(379) MS (ESI): 444.82 (M+H).

Example 2 I

N-(4-(4-(ethylcarbamoyl)phenylsulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide

(380) ##STR01593##

a. 4-((4-cyanophenylthio)benzoic Acid

(381) ##STR01594##

(382) In a 250 mL round-bottomed flask was added 4-fluorobenzonitrile (2.121 g, 17.51 mmol), 4-mercaptobenzoic acid (3 g, 17.51 mmol), and potassium carbonate (7.26 g, 52.5 mmol) in DMF (Volume: 50 mL). The reaction was heated to 100° C. overnight and monitored by LCMS. When complete, the slurry was treated with 100 mL of water to give a clear solution. The solution was then treated with 6M aq. HCl slowly until pH<4 upon which a precipitate formed. The slurry was filtered and washed with water to give 14.8 g of crude product after drying briefly on filter. NMR showed product, an impurity and water. Dried in vacuum oven overnight to give 4.41 g of material which was adsorbed onto 50 g of silica gel and then plug filtered with 10% MeOH/CH.sub.2Cl.sub.2 to give 3.45 g of material which was used without further purification.

(383) .sup.1H NMR (300 MHz, DMSO-d6): δ 13.18 (br s, 1H), 7.96 (d, 2H), 7.80 (d, 2H), 7.52 (d, 2H), 7.42 (d, 2H).

b. 4-(4-cyanophenylthio)-N-ethylbenzamide

(384) ##STR01595##

(385) In a 500 mL round-bottomed flask was added 4-(4-cyanophenylthio)benzoic acid (3.45 g, 13.51 mmol), HBTU (5.13 g, 13.51 mmol) and HOBT (2.070 g, 13.51 mmol) in DMF (Volume: 100 mL) followed by ethanamine (2M in THF, 20.27 mL, 40.5 mmol). The reaction was stirred overnight and then concentrated under reduced pressure. The residue was dissolved in ethyl acetate and washed with 2M aq. NaOH, water and brine. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and concentrated to give 2.81 g of product. Material used without further purification.

(386) .sup.1H NMR (300 MHz, DMSO-d6): δ 8.57 (t, 1H), 7.89 (d, 2H), 7.75 (d, 2H), 7.55 (d, 2H), 7.31 (d, 2H), 3.30 (m, 2H), 1.10 (t, 3H).

c. 4-(4-cyanophenylsulfonyl)-N-ethylbenzamide

(387) ##STR01596##

(388) In a 500 mL round-bottomed flask was added 4-(4-cyanophenylthio)-N-ethylbenzamide (2.81 g, 9.95 mmol) in chloroform (Volume: 50 mL) which was cooled to 0° C. followed by the addition of mCPBA (6.87 g, 29.9 mmol). The reaction was stirred for 1 hour at 0° C. and then warmed to room temperature overnight. The reaction was diluted with chloroform and poured into a separatory funnel. The organic layer was washed with 10% aqueous sodium thiolsulfate, 2M NaOH, and saturated, aqueous sodium chloride. The bottom was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 2.79 g of crude product. Material purified on Biotage to give 2.42 g of pure product (70% yield).

(389) .sup.1H NMR (300 MHz, DMSO-d6): δ 8.68 (t, 1H), 8.15 (d, 2H), 8.09 (m, 4H), 7.95 (d, 2H), 3.28 (m, 2H), 1.02 (t, 3H).

(390) LC-MS (ESI): 314.92 (M+1).

d. 4-(4-(aminomethyl)phenylsulfonyl)-N-ethylbenzamide

(391) ##STR01597##

(392) A slurry of Raney Nickel (0.660 g, 7.70 mmol) was added to a Paar flask and washed with methanol. The MeOH was removed by pipette and the process repeated twice more. 4-(4-cyanophenylsulfonyl)-N-ethylbenzamide (2.42 g, 7.70 mmol) in MeOH (Volume: 50 mL)) was then added followed by potassium hydroxide (0.043 g, 0.770 mmol) and ammonia (7M, 11.00 mL, 77 mmol) in MeOH. The slurry was placed on the Paar shaker and hydrogenated at 35 psi overnight. Reaction monitored by LCMS. The solution was then filtered through celite and washed with MeOH. The solution was then concentrated under reduced pressure to give 2.56 g of product. Material purified on Biotage to give 2.03 g of product (83% yield).

(393) .sup.1H NMR (300 MHz, DMSO-d6): δ 8.65 (t, 1H), 7.98 (m, 4H), 7.88 (d, 2H), 7.55 (d, 2H), 3.76 (d, 2H), 3.24 (m, 2H), 2.10 (br s, 2H), 1.15 (t, 3H).

(394) LC-MS (ESI): 318.95 (M+1).

e. N-(4-(4-(ethylcarbamoyl)phenylsulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide

(395) ##STR01598##

(396) In a 250 mL round-bottomed flask was added 4-(4-(aminomethyl)phenylsulfonyl)-N-ethylbenzamide (1 g, 3.14 mmol), imidazo[1,2-a]pyridine-6-carboxylic acid (0.509 g, 3.14 mmol) and HATU (1.314 g, 3.45 mmol) in DMF (Volume: 50 mL) followed by DIEA (1.207 mL, 6.91 mmol). The reaction was stirred overnight and then concentrated under reduced pressure. The reaction was diluted with methylene chloride and poured into a separatory funnel. The organic layer was washed with 1M NaOH and water. The bottom was separated and concentrated and purified directly on the Biotage to give 514 mg of clean product (35% yield).

(397) .sup.1H NMR (300 MHz, DMSO-d6): δ 9.19 (t, 1H), 9.11 (t, 1H), 8.64 (t, 1H), 8.04-9.92 (m, 7H), 6.63 (m, 3H), 7.55 (d, 2H), 4.53 (d, 2H), 3.25 (m, 2H), 1.08 (t, 3H).

(398) LC-MS (ESI): 463.05 (M+1).

Example 2 J

N-(4-((3-methoxyphenyl)sulfonyl)benzyl)imidazo[1,2-a]pyrimidine-6-carboxamide

(399) ##STR01599##

(400) The title compound was prepared with 80% yield by following Example 4D.

(401) .sup.1H NMR 6 (d.sub.6-dmso) 9.47 (1H, d); 9.34 (1H, t); 8.92 (1H, d); 8.01 (1H, d); 7.95 (2H, d); 7.80 (1H, d); 7.58 (2H, d); 7.54-7.47 (2H, m); 7.42-7.41 (1H, m); 7.23 (1H, dt); 4.57 (2H, d and 3.81 (3H, s).

(402) LC-MS (ESI): 422.9 (M+1).

Example 2 K

N-(4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl) benzyl) imidazo [1, 2-a]pyridine-6-carboxamide

(403) ##STR01600##

a. N-(4-((1-isopropyl-1H-Pyrazol-4-yl) sulfonyl) benzyl) acetamide

(404) ##STR01601##

(405) In a 1 μL round-bottomed flask were added sodium 4-(acetamidomethyl)benzenesulfinate (3.97 g, 16.89 mmol, 1.3 eq.), 1-isoproyl 1H-pyrazol-4-ylboronic acid (2 g, 12.99 mmol)] and COPPER (II) ACETATE (2.6 g, 14.29 mmol)), POTASSIUM CARBONATE (3.95 g, 28.6 mmol) in DMSO (50 ml) followed by 10 g of 4 Å molecular sieves. The reaction was stirred overnight. Added water and EtOAc, filtered through a short celite pad, added EtOAc, washed with water twice, dried and concentrated. The biotage column purification afforded 1.9 g of N-(4-((1-isopropyl-1H-Pyrazol-4-yl) sulfonyl) benzyl) acetamide (45%).

(406) .sup.1HNMR (DMSO-D.sub.6): δ 8.50 (s, 1H). 8.42 (t, 1H), 7.91 (s, 1H), 7.86 (d, 2H), 7.43 (d, 2H), 4.52 (m, 1H), 4.28 (d, 2H), 1.36 (d, 6H)

b. (4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl) phenyl) methanamine HCl

(407) ##STR01602##

(408) The mixture of a 3M HCl solution (80 ml) and, N-(4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl)benzyl)acetamide (1.9 g, 5.91 mmol) in 2-Propanol (100 ml) was refluxed for over weekend, removed solvent, added ether, filtered and dried to afford 1.4 g of (4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl)phenyl)methanamine HCl salt (75%)

(409) .sup.1HNMR (DMSO-d.sub.6): δ 8.50 (s, 1H), 7.94-7.98 (m, 3H), 7.85 (dd, 1H), 7.69 (d, 2H), 4.52 (m, 1H), 4.08 (d, 2H), 1.37 (d, 6H).

c. N-(4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl) benzyl) imidazo [1, 2-a]pyridine-6-carboxamide

(410) ##STR01603##

(411) In a 250 mL round-bottomed flask were added imidazo[1,2-a]pyridine-6-carboxylic acid (0.719 g, 4.43 mmol), (4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl)phenyl)methanamine, HCl (1.4 g, 4.43 mmol) and HBTU (1.849 g, 4.88 mmol), HOBT (0.747 g, 4.88 mmol) and DIEA (3.87 mL, 22.16 mmol) in DMF (Volume: 50 mL). The reaction was stirred overnight and then concentrated under reduced pressure. The residue was diluted with methylene chloride and washed with 1M aq. NaOH. The organic layer was separated and concentrated and directly purified in the Biotage to give 1.24 g of N-(4-(1-isopropyl-1H-pyrazol-4-ylsulfonyl) benzyl) imidazo [1, 2-a] pyridine-6-carboxamide.

(412) .sup.1HNMR (DMSO-D.sub.6): δ 9.20 (t, 1H), 9.13 (s, 2H), 8.51 (s, 1H), 8.05 (s, 1H), 7.88-7.91 (m, 3H), 7.53-7.67 (m, 4H), 4.42-4.55 (m, 3H), 1.37 (d, 6H).

(413) LC-MS: 424.01 (M+1)

Example 2 L

N-(4-(phenylsulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

(414) ##STR01604##

(415) The mixture of 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (0.8 g, 4.90 mmol), HATU (1.87 g, 4.90 mmol), diisopropylethylamine (1.2 mL, 6.69 mmol), and (4-(phenylsulfonyl) phenyl)methanamine (1.10 g, 4.46 mmol) in DMF (50 mL) was stirred at room temperature for 16 h. The DMF was removed under reduced pressure. 150 mL of water was added to the residue and extracted with EtOAc (3×100 mL). The combined organic layers was washed with water, saturated sodium bicarbonate, brine, dried with sodium sulfate, and concentrated in vacuo. The crude was purified by Biotage with MeOH/DCM (0%-10%) to yield the title compound.

(416) .sup.1H NMR (DMSO-d6): 9.27 (t, 1H), 8.98 (d, 1H), 8.72 (d, 1H), 8.27 (s, 1H), 7.94-7.90 (m, 4H), 7.66-7.55 (m, 5H), 4.56 (d, 2H).

(417) LC-MS: 393.01 (M+1).

Example 2 M

N-(4-(2,4-dimethylthiazol-5-ylsulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide

(418) ##STR01605##

(419) A mixture of copper iodide (0.2 M DMSO, 100 μL, 20 μmol), cesium (S)-pyrrolidine-2-carboxylate (0.2 M DMSO w/14% MeOH (v/v), 200 μL, 40 μmol), sodium 4-(acetamidomethyl)benzenesulfinate (0.2 M DMSO, 200 μL, 40 μmol) and 5-bromo-2,4-dimethylthiazole (0.2 M DMSO, 240 μL, 48 μmol) was heated at 90° C. with shaking over night. The reaction was treated with aqueous ammonia and extracted with EtOAc and the organic extract was concentrated to dryness and the resulting residue was dissolved in 70% i-PrOH (0.35 mL) and 3N HCl (0.35 mL, 1.05 mmol) and was heated at 90° C. for 4 hours then concentrated to dryness. The residue was treated with triethylamine (5% in ACN (v/v), 200 uL) and imidazo[1,2-a]pyridine-6-carboxylic acid (0.2 M in DMA w/10% TEA (v/v), 240 uL, 48 umol) and BOP (0.2 M DCE, 260 uL, 52 umol). The solution was heated to 40° C. for 4 h then cooled to room temperature and partitioned between NaOH and EtOAc. The organic layer was separated and concentrated in vacuo. The crude was purified by LC/MS to afford the title compound as white solid.

(420) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 8.87 (dd, J=1.6 Hz, J′=0.8 Hz 1H), 7.89 (dt, J=8.4 Hz, J′=2 Hz, 2H), 7.71 (d, J=1.6 Hz, 1H), 7.67 (s, 1H), 7.60 (d, J=9.2 Hz, 1H), 7.50 (d, J=8.4 Hz 2H), 7.43 (dd, J=9.2 Hz, J′=2 Hz, 1H), 6.84 (bs, 1H), 4.73 (d, J=6 Hz, 2H), 2.65 (s, 3H), 2.57 (s, 3H).

(421) LC-MS: 427.10 (M+1)

Example 2 N

N-(3-(naphthalen-2-ylsulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide

(422) ##STR01606##

(423) To a mixture of sodium 4-(acetamidomethyl)benzenesulfinate (0.2 M MeOH, 100 μL, 20 μmol) and zinc chloride (0.5 M THF, 40 μL, 20 μmol), cesium carbonate (1.43 M MeOH, 25 μL, 35 μmol) then 2-bromonapthelene (0.2 M Toluene, 110 μL, 22 μmol) were added. A toluene solution of XantPhos and Pd.sub.2dba.sub.3 (0.01 M XantPhos/0.005 M Pd.sub.2dba.sub.3, 50 μL, 2.5 mol %) was added and the reaction was heated for 4 h at 95° C. under nitrogen. The reaction was cooled to room temperature and 70% i-PrOH (0.35 mL) and 3N HCl (0.35 mL, 1.05 mmol) were added and was heated at 95° C. for 4 hours then concentrated to dryness. The residue was treated with triethylamine (5% in ACN (v/v), 100 μL) and imidazo[1,2-a]pyridine-6-carboxylic acid (0.2 M in DMA w/10% TEA (v/v), 120 μL, 24 μmol) and BOP (0.2 M DCE, 130 μL, 26 μmol). The solution was heated to 40° C. for 4 h then cooled to room temperature and partitioned between NaOH and EtOAc. The organic layer was separated and deposited on a SCX-SPE cartridge which was eluted to two fractions: the 1.sup.st with 25% McOH/EtOAc (v/v), the 2.sup.nd with Et3N/MeOH/EtOAc (1:1:10 v/v/v). The second fraction was concentrated to dryness and was purified by LC/MS to afford the title compound as white solid.

(424) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 8.85 (s, 1H), 8.55 (s, 1H), 7.93 (m, 4H), 7.87 (d, J=8 Hz, 1H), 7.81 (dd, J=8.8 Hz, J′=1.6 Hz, 1H), 7.63 (m, 5H), 7.47 (d, J=8.4 Hz, 2H), 7.34 (m, 1H), 6.81 (m, 1H), 4.70 (d, J=5.6 Hz, 2H).

(425) LC-MS: 442.13 (M+1)

Example 2 O

N-(4-(naphthalen-2-ylsulfonyl)benzyl)furo[2,3-c]pyridine-2-carboxamide

(426) ##STR01607##

a. Tert-Butyl 4-bromobenzylcarbamate

(427) ##STR01608##

(428) A 200-mL RBF equipped with a magnetic stir bar was charged with (4-bromophenyl)methanamine hydrochloride (5.23 g, 23.50 mmol), K.sub.2C03 (3.90 g, 28.2 mmol), MeTHF (Ratio: 4.00, Volume: 50 ml), and Water (Ratio: 1.000, Volume: 12.5 ml). To the resulting mixture was added BOC.sub.2O (6.00 ml, 25.9 mmol) in one portion at rt with stirring. LCMS after 1 h suggested clean, complete conversion. The mixture was diluted with additional MeTHF (50 mL) and water (10 mL), and the layers separated. The organic layer was washed with half-saturated brine (2×25 mL) and then concentrated under reduced pressure to 7.2 g of a white solid. The crude product was used without further purification in the next step.

(429) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 7.44 (d, J=8.4 Hz, 2H), 7.15 (d, J=8.3 Hz, 2H), 4.85 (br s, 1H), 4.26 (d, J=5.8 Hz, 2H), 1.45 (s, 9H) ppm.

b. Methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenylthio)propanoate

(430) ##STR01609##

(431) A 200-mL RBF equipped with a magnetic stir bar and containing tert-butyl 4-bromobenzylcarbamate, crude (6.72 g, 23.5 mmol) was charged with Toluene (Volume: 50 ml), Hunig'sBase (8.21 ml, 47.0 mmol), XANTPHOS (0.680 g, 1.175 mmol), Pd.sub.2(dba).sub.3 (0.538 g, 0.588 mmol), and finally methyl 3-mercaptopropanoate (2.60 ml, 23.50 mmol). The mixture was then heated to 100° C. LCMS after 1 h suggested significant conversion, although starting bromide was still evident by 220 nm. LCMS after 2 h a little better. After 2.5 h, heating was discontinued. After cooling, the mixture was loaded directly on a short silica gel column. Elution with 5:1 hexanes-EtOAc, 4:1 hexanes-EtOAc, and finally 3:1 hexanes-EtOAc afforded methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenylthio)propanoate (7.19 g, 22.09 mmol, 94% yield) as a nearly colorless oil.

(432) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 7.32 (d, J=8.3 Hz, 2H), 7.21 (d, J=8.2 Hz, 2H), 4.84 (br s, 1H), 4.28 (d, J=5.8 Hz, 2H), 3.67 (s, 3H), 3.14 (t, J=7.4 Hz, 2H), 2.61 (t, J=7.5 Hz, 2H), 1.45 (s, 9H) ppm.

(433) ESMS: 348.15 (M+Na)

c. Methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenylsulfonyl)propanoate

(434) ##STR01610##

(435) A 500-mL RBF equipped with a magnetic stir bar was charged with OXONE (23.61 g, 38.4 mmol) and Water (Ratio: 1.822, Volume: 82 ml). The mixture was stirred at rt for 5 min in order to dissolve the Oxone. Next, a solution of methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenylthio)propanoate (5.0 g, 15.36 mmol) in Acetonitrile (Ratio: 1.000, Volume: 45 ml) was added at rt with rapid stirring. The mixture was stirred at rt. After 2.5 h, an aliquot was removed, worked up, and analyzed by .sup.1H NMR, which confirmed complete conversion to sulfone. LCMS also looked good. The reaction mixture was then extracted with EtOAc (100 mL). This extract was concentrated under reduced pressure. The aqueous layer was re-extracted once with fresh EtOAc. This extract was combined with the first, concentrated extract. The combined solution was washed twice with half-saturated brine (2×50 mL) and concentrated under reduced pressure to afford methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenylsulfonyl)propanoate (5.17 g, 14.46 mmol, 94% yield) as a white solid.

(436) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 7.86 (d, J=8.4 Hz, 2H), 7.48 (d, J=8.6 Hz, 2H), 5.03 (br s, 1H), 4.41 (d, J=6.2 Hz, 2H), 3.64 (s, 3H), 3.41 (t, J=7.7 Hz, 2H), 2.74 (t, J=7.8 Hz, 2H), 1.46 (s, 9H) ppm.

(437) ESMS: 380.07 (M+Na)

d. Methyl 3-(4-(aminomethyl)phenylsulfonyl)propanoate Hydrochlorid

(438) ##STR01611##

(439) A 200-mL RBF equipped with a magnetic stir bar and containing methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenylsulfonyl)propanoate (5.16 g, 14.44 mmol) was charged with MeOH (Volume: 50 ml) followed by HYDROCHLORIC ACID, cone (1.323 ml, 15.88 mmol). The solution was then heated to 50° C. LCMS after overnight indicated complete conversion. Heating was discontinued. After cooling, the slurry was concentrated partially under reduced pressure, removing 32 mL of MeOH. The resulting concentrated slurry was diluted with MTBE (50 mL). The slurry was stirred at rt for 30 min, then filtered on a glass, medium frit, 60-mL Buchner funnel. The filter cake was washed with MTBE and dried under suction and a positive pressure of nitrogen to afford methyl 3-(4-(aminomethyl)phenylsulfonyl)propanoate hydrochloride (4.10 g, 13.96 mmol, 97% yield) as a snow-white, crystalline, free-flowing solid.

(440) .sup.1H NMR (400 MHz, DMSO-d.sub.6): δ 8.62 (br s, 2H), 7.92 (d, J=8.5 Hz, 2H), 7.77 (d, J=8.4 Hz, 2H), 4.14 (s, 2H), 3.58 (t, J=7.3 Hz, 2H), 3.52 (s, 3H), 2.59 (t, J=7.3 Hz, 2H) ppm.

(441) ESMS: 258.10 (M+1).

e. Methyl 3-(4-((furo[2,3-c]pyridine-2-carboxamido)methyl)phenylsulfonyl)propanoate

(442) ##STR01612##

(443) A 25-mL RBF equipped with a magnetic stir bar was charged with furo[2,3-c]pyridine-2-carboxylic acid (135 mg, 0.828 mmol), methyl 3-(4-(aminomethyl)phenylsulfonyl)propanoate hydrochloride (243 mg, 0.828 mmol), EtOH (Volume: 2.7 ml), N-METHYLMORPHOLINE (0.218 ml, 1.986 mmol), and finally EDC (190 mg, 0.993 mmol). The reaction mixture was stirred at rt. LCMS after 75 min shows some conversion, with longer-retaining by-product also forming. LCMS after 3 h shows some more conversion, but not significant. After 3.5 h, HOBT (6.34 mg, 0.041 mmol) was added. LCMS, 75 min after HOBT addition, not much different. LCMS after overnight not much different. The reaction mixture was slowly diluted with water (8.1 mL). The resulting slurry was stirred at rt for 1 h, then filtered on a 30-mL, medium frit, glass Buchner funnel. The solid was washed with water and dried under suction and a positive pressure of nitrogen to yield methyl 3-(4-((furo[2,3-c]pyridine-2-carboxamido)methyl)phenylsulfonyl)propanoate (0.12 g, 0.298 mmol, 36.0% yield) as a slightly off-white fluffy powder.

(444) .sup.1H NMR (400 MHz, DMSO-d.sub.6): 9.67 (t, J=6.1 Hz, 1H), 9.05 (s, 1H), 8.47 (d, J=5.2 Hz, 1H), 7.85 (d, J=8.4 Hz, 2H), 7.82 (dd, J=5.3, 1.1 Hz, 1H), 7.65 (d, J=0.8 Hz, 1H), 7.60 (d, J=8.4 Hz, 2H), 4.59 (d, J=6.1 Hz, 2H), 3.53 (t, J=7.2 Hz, 2H), 3.49 (s, 3H), 2.59 (t, J=7.2 Hz, 2H) ppm.

(445) ESMS: 403.03 (M+1)

f. Sodium 4-((furo[2,3-c]pyridine-2-carboxamido)methyl)benzenesulfinate

(446) ##STR01613##

(447) A 25-mL RBF equipped with a magnetic stir bar was charged with methyl 3-(4-((furo[2,3-c]pyridine-2-carboxamido)methyl)phenylsulfonyl)propanoate (113 mg, 0.281 mmol) followed by a solution of SODIUM ETHOXIDE (21 wt % in EtOH) (91 mg, 0.281 mmol) dissolved in MeOH (Volume: 2 ml). The mixture was stirred at rt. Over time, the solid dissolved. LCMS after 30 min shows ca 80-85% conversion. LCMS after 1 h shows essentially complete conversion. Note: no transient intermediate/by-product isomeric with the SM was observed as in the case with the analogous azaindole experiments. LCMS after 2 h shows complete, clean conversion. After 2.5 h, the solution was concentrated under a gentle stream of nitrogen overnight to afford sodium 4-((furo[2,3-c]pyridine-2-carboxamido)methyl)benzenesulfinate (0.102 g, 0.301 mmol, 107% yield) as an off-white/light tan solid.

(448) .sup.1H NMR (400 MHz, DMSO-d.sub.6): δ 8.99 (s, 1H), 8.42 (d, J=5.2 Hz, 1H), 7.76 (dd, J=5.2, 1.1 Hz, 1H), 7.55 (d, J=0.6 Hz, 1H), 7.38 (d, J=8.0 Hz, 2H), 7.25 (d, J=8.1 Hz, 2H), 4.44 (s, 2H) ppm.

(449) ESMS: 317.04 (M+1)

g. N-(4-(naphthalen-2-ylsulfonyl)benzyl)furo[2,3-c]pyridine-2-carboxamide

(450) ##STR01614##

(451) To a mixture of naphthylen-2-boronic acid (0.2 M dioxane, 150 μL, 30 μmol) and diacetoxycopper (0.2 M DMSO, 150 μL, 30 μmol) and triethylamine (Neat, 9.3 μL, 67 μmol), sodium 4-((furo[2,3-c]pyridine-2-carboxamido)methyl) benzene sulfinate (0.2 M DMSO, 50 μL, 10 μmol) was added and the reaction was heated at 40° C. over night. The reaction was cooled to room temperature and partitioned between aqueous ammonia and EtOAc. The organic layer was separated and deposited on a SCX-SPE cartridge which was eluted to two fractions: the 1.sup.st with 25% MeOH/EtOAc (v/v), the 2.sup.nd with ammonia in methanol (2 N). The second fraction was concentrated to dryness and was purified by LC/MS to afford the title compound as white solid.

(452) .sup.1H NMR (400 MHz, CDCl.sub.3): δ 8.89 (s, 1H), 8.56 (d, J=2 Hz, 1H), 8.50 (d, J=5.2 Hz, 1H), 7.99 (m, 3H), 7.92 (d, J=8.8 Hz, 1H), 7.87 (m, 2H), 7.62 (m, 3H), 7.51 (m, 3H), 7.08 (m, 1H), 4.72 (d, J=6.4 Hz, 2H).

(453) LC-MS: 443.22 (M+1)

Example 2 P

N-(4-(5-(dimethylamino) pyrazin-2-ylsulfonyl) benzyl) imidazo [1, 2-a]pyridine-6-carboxamide

(454) ##STR01615##

a. N-(4-(5-(dimethylamino)pyrazin-2-ylsulfonyl)benzyl) Acetamide

(455) ##STR01616##

(456) The mixture of XANTPHOS (0.573 g, 0.990 mmol), Cs2CO3 (6.45 g, 19.80 mmol), Pd2(dba)3 (0.453 g, 0.495 mmol), 4-(acetamidomethyl)benzenesulfinic acid, sodium salt (3.51 g, 14.85 mmol), 5-bromo-N,N-dimethylpyrazin-2-amine (2 g, 9.90 mmol) in Toluene (50 ml) was degassed and heated to 120° C. for overnight. Cooled to RT, added EtOAc, washed with water, dried and concentrated, The Biotage purification afforded 1.6 g of the target compound (48%).

(457) .sup.1HNMR (CDCl.sub.3): δ 8.75 (s, 1H). 8.03 (s, 1H), 7.87 (d, 2H), 7.38 (d, 2H), 6.11 (b, 1H), 4.45 (d, 2H), 3.21 (s, 6H), 2.16 (s, 3H).

b. 5-((4-(aminomethyl)phenyl)sulfonyl)-N, N-dimethylpyrazin-2-amine Hydrochloride

(458) ##STR01617##

(459) The mixture of a 3M HCl solution (80 ml) and, N-(4-(5-(dimethylamino)pyrazin-2-ylsulfonyl)benzyl)acetamide (1.6 g) in 2-Propanol (100 ml) was refluxed for over weekend, removed solvent, added ether, filtered and dried to afford 1.2 g of the target compound as a hydrochloride (76%).

(460) .sup.1HNMR (DMSO-D.sub.6): 8.71 (s, 1H), 8.14 (s, 1H), 7.92 (d, 2H), 7.45 (d, 2H), 4.08 (d, 2H), 3.13 (s, 6H).

c. N-(4-(5-(dimethylamino) pyrazin-2-ylsulfonyl) benzyl) imidazo [1, 2-a]pyridine-6-carboxamide

(461) ##STR01618##

(462) In a 250 mL round-bottomed flask was added imidazo [1, 2-a] pyridine-6-carboxylic acid (0.592 g, 3.65 mmol), 5-(4-(aminomethyl) phenylsulfonyl)-N, N-dimethylpyrazin-2-amine, HCl (1.2 g, 3.65 mmol) and HBTU (1.522 g, 4.01 mmol), HOBT (0.615 g, 4.01 mmol) and DIEA (3.19 mL, 18.25 mmol) in DMF (50 mL). The reaction was stirred overnight and then concentrated under reduced pressure. The residue was diluted with methylene chloride and washed with 1M aq. NaOH. The organic layer was separated and concentrated and directly purified in the Biotage to give 235 mg of N-(4-(5-(dimethylamino) pyrazin-2-ylsulfonyl) benzyl) imidazo [1, 2-a] pyridine-6-carboxamide (15%).

(463) .sup.1HNMR (DMSO-d.sub.6): δ 9.21 (t, 1H), 9.13 (s, 1H), 8.67 (s, 1H), 8.12 (s, 1H), 8.95 (s, 1H), 7.86 (d, 2H), 7.63 (d, 2H), 7.54 (d, 2H), 4.53 (d, 2H), 3.11 (s, 6H).

(464) LC-MS: 437.0 (M+1)

Example 2 Q

N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)benzyl)imidazo[1,2-a]pyrimidine-6-carboxamide

(465) ##STR01619##

a: 4-((3-(trifluoromethoxy)phenyl)thio)benzonitrile

(466) ##STR01620##

(467) To a colorless solution of 3-(trifluoromethoxy)benzenethiol (5.0 g, 25.8 mmol) in DMF (80 mL) was added K.sub.2C03 (4.21 g, 30.4 mmol) forming a yellow mixture. To this mixture was added 4-fluorobenzonitrile (2.84 g, 23.4 mmol). The mixture was heated to 120° C. for 16 h, cooled to room temperature, and diluted with 1N NaOH and Et20. The layers were separated. The organic layer was washed sequentially with 1N NaOH and brine, dried over Na.sub.2SO.sub.4, and concentrated in vacuo. The residue was purified by Biotage SP1 to afford the desired product as colorless oil (6.09 g, 88% yield).

(468) .sup.1H NMR (300 MHz, CDCl.sub.3): δ 8.8-8.06 (m, 2H), 7.89-7.80 (m, 2H), 7.78-7.82 (m, 2H), 7.61 (t, 1H), 7.47 (d, 2H).

(469) LC-MS: 295.93 (M+H).

b: 4-((3-(trifluoromethoxy)phenyl)sulfonyl)benzonitrile

(470) ##STR01621##

(471) To a solution of 4-(3-(trifluoromethoxy)phenylthio)benzonitrile (6.09 g, 20.6 mmol) in CHCl.sub.3 (110 mL) at 0° C. was added mCPBA (20.88 g, 91.0 mmol). The mixture was stirred and warmed to room temperature slowly overnight. The solids were removed by vacuum filtration, rinsed with CHCl.sub.3. The filtrate was washed with 1N NaOH (×2). The separated organic layer was washed with water and brine, dried over Na.sub.2SO.sub.4, filtered, concentrated to afford the product without further purification for next step (6.00 g, 89%).

(472) .sup.1H NMR (300 MHz, CDCl.sub.3): δ 8.08 (d, 1H), 8.06 (d, 1H), 7.89-7.80 (m, 4H), 7.61 (t, 1H), 7.49-7.43 (m, 1H).

(473) LC-MS: 349.90 (M+Na).

c: (4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)methanamine

(474) ##STR01622##

(475) To a small flask was added 3 pipette-full slurry of Raney Ni in water and then added methanol (2 mL). The wash solvent (MeOH) was removed via pipette. The wash was repeated twice more, affording about 7 equivalents of nickel. To a 500 mL Parr reaction cylinder was added 4-(3-(trifluoromethoxy)phenylsulfonyl)benzonitrile (6.00 g, 18.3 mmol) in MeOH (120 ml), followed by addition of the prewashed nickel, 7N ammonia (37.2 ml, 26.0 mmol) in MeOH and potassium hydroxide (0.329 g, 5.9 mmol). The mixture was vacuumed and purged with H.sub.2 three times, then hydrogenated at 50 psi overnight. LC-MS analysis indicated the completion of the hydrogenation of nitrile. The mixture was filtered through celite. The filtrate was concentrated and purified by Biotage SP1 affording the product as light yellow oil (4.20 g, 93% yield).

(476) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 7.99-7.91 (m, 4H), 7.75-7.73 (m, 3H), 7.58 (d, 2H), 3.76 (s, 2H).

(477) LC-MS: 331.97 (M+H).

d: N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)benzyl)imidazo[1,2-a]pyrimidine-6-carboxamide

(478) ##STR01623##

(479) A mixture of imidazo[1,2-a]pyrimidine-6-carboxylic acid (0.739 g, 4.53 mmol), (4-(3-(trifluoromethoxy)phenylsulfonyl)phenyl)methanamine (1.5 g, 4.53 mmol), BOP (2.203 g, 4.98 mmol) and DIEA (0.949 mL, 5.43 mmol) in DMF (25 mL) was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo to remove the DMF. The residue was diluted with EtOAc and then washed with 1N NaOH. The separated aqueous layer was back-extracted with EtOAc. The combined organic extracts were washed with 5% AcOH, water, brine and dried (Na.sub.2SO.sub.4), filtered and concentrated. Purification by Biotage SP1 of the crude afforded the title compound as off-white solids (980 mg, 45% yield).

(480) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 9.47 (d, 1H), 9.35 (t, 1H), 9.23 (d, 1H), 8.01-7.98 (m, 5H), 7.80-7.31 (m, 3H), 7.60 (d, 2H), 4.57 (d, 2H).

(481) LC-MS: 476.87 (M+1).

Example 2 R

N-(4-(benzylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(482) ##STR01624##

a: N-(4-(benzylsulfonyl)benzyl)acetamide

(483) ##STR01625##

(484) To a solution of sodium 4-(acetamidomethyl)benzenesulfinate (1 g, 4.25 mmol) in water (12 mL) were added TBAI (0.157 g, 0.425 mmol) and (bromomethyl)benzene (0.742 g, 4.34 mmol) under N.sub.2 flow. The reaction mixture was heated to 70° C. for 2 h. The white solids were precipitated out. LC-MS analysis showed that the major peak was the desired product. The white solids were filtered and washed with water and ether to remove TBAI, then dried under reduced pressure to give 696 mg of desired product with 90% HPLC purity. The collected solids were used for next step without further purification.

(485) .sup.1H NMR (300 MHz, CDCl.sub.3): δ 7.55 (d, 2H), 7.33-7.23 (m, 5H), 7.08 (d, 2H), 5.94 (brs, 1H), 4.50 (d, 2H), 4.29 (s, 2H), 2.07 (s, 3H).

(486) LC-MS: 304.12 (M+H).

b: (4-(benzylsulfonyl)phenyl)methanamine Hydrochloride

(487) ##STR01626##

(488) A mixture of N-(4-(benzylsulfonyl)benzyl)acetamide (300 mg, 0.989 mmol) and 3N HCl (11.87 ml, 35.6 mmol) in .sup.iPrOH (11 mL) was heated to 100° C. The cloudy mixture turned to a clear solution as temperature rose. The reaction mixture was stirred for 16 h at 100° C. LC-MS analysis indicated completion of hydrolysis. The reaction mixture was allowed to cool to room temperature. The white crystals were precipitated and filtered, rinsed with cold mixture of PrOH/ether to afford hydrochloride salt of the desired product (235 mg, 80% yield).

(489) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 8.44 (brs, 3H), 7.75, 7.65 (dd, 4H), 7.29-7.27 (m, 3H), 7.16-7.13 (m, 2H), 4.69 (s, 2H), 4.12 (s, 2H).

(490) LC-MS: 262.11 (M+H).

c: N-(4-(benzylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(491) ##STR01627##

(492) 1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (57.2 mg, 0.353 mmol), 1H-benzo[d][1,2,3]triazol-1-ol (59.0 mg, 0.437 mmol) and EDC (86 mg, 0.450 mmol) were dissolved in anhydrous THF (4 mL), followed by addition of Hunig's base (0.12 mL, 0.7 mmol). The mixture formed a slurry solution. DMF (1 mL) was added. After stirring for 15 min., (4-(benzylsulfonyl) phenyl)methanamine hydrochloride (100 mg, 0.336 mmol) and Hunig's base (0.12 mL, 0.7 mmol) in THF (1 mL) was added. The reaction mixture was heated and stirred at 65° C. overnight, then diluted with ethyl acetate (×2). The combined organic layers were washed sequentially with 5% aqueous acetic acid (×1), saturated aqueous sodium bicarbonate (×2), and brine (×1). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to yield a crude product (65 mg). The crude was dissolved in DCM and a few drops of MeOH, and purified by Biotage to give the desired product (34 mg, 25% yield).

(493) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 12.05 (s, 1H), 9.31 (t, 1H), 8.93 (s, 1H), 8.21 (d, 1H), 7.68 (d, 2H), 7.51 (d, 2H), 7.36-7.26 (m, 5H), 7.16-7.13 (m, 2H), 4.63 (s, 2H), 4.59 (d, 2H).

(494) LC-MS: 406.11 (M+H).

Example 2 S

N-(4-(cyclohexylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(495) ##STR01628##

a: N-(4-(cyclohexylsulfonyl)benzyl)acetamide

(496) ##STR01629##

(497) To a solution of sodium 4-(acetamidomethyl)benzenesulfinate (500 mg, 2.126 mmol) in DMSO (8 mL) was added iodocyclohexane (670 mg, 3.19 mmol). The reaction was heated up to 100° C. for 48 h. The reaction mixture was diluted with EtOAc, and washed with water (×1) and brine (×2). The organic was dried over Na.sub.2SO.sub.4 and concentrated. The crude was purified by Biotage to yield the desired product (52 mg, 8% yield).

(498) .sup.1H NMR (300 MHz, CDCl.sub.3): δ 7.66 (d, 2H), 7.36 (d, 2H), 6.72 (m, 1H), 4.46 (d, 2H), 2.83 (tt, 1H), 2.04 (s, 3H), 2.01-2.00 (m, 2H), 1.83-1.76 (m, 3H), 1.65 (d, 1H), 1.93-1.12 (m, 4H).

(499) LC-MS: 296.06 (M+H).

b: (4-(cyclohexylsulfonyl)phenyl)methanamine

(500) ##STR01630##

(501) A mixture of N-(4-(cyclohexylsulfonyl)benzyl)acetamide (52 mg, 0.176 mmol) and 3N HCl (2.11 mL, 6.34 mmol) in .sup.iPrOH (2.5 mL) was heated to 100° C. The cloudy mixture turned to a clear solution as temperature rose. The reaction mixture was stirred and refluxed for 16 h at 100° C. LC-MS analysis indicated that no starting material was present and some other by-product was formed (the desired product showed as 22% in HPLC). The mixture was cooled to RT and the solvent was concentrated. The resulting slurry was treated with 1N NaOH and EtOAc. The combined organic extracts were washed with brine, dried and concentrated to yield a crude product (120 mg). The crude was purified by Biotage to yield the free amine (25 mg, 56% yield).

(502) LC-MS: 254.08 (M+H).

c: N-(4-(cyclohexylsulfonyl)benzyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(503) ##STR01631##

(504) 1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid (16.80 mg, 0.104 mmol), 1H-benzo[d][1,2,3]triazol-1-ol (17.33 mg, 0.128 mmol) and EDC (25.3 mg, 0.132 mmol) were dissolved in anhydrous THF (3 mL), followed by addition of Hunig's base (0.7 mL, 0.7 mmol). The mixture formed a slurry solution. DMF (0.5 mL) was added. After stirring for 15 min at 65° C., (4-(cyclohexylsulfonyl)phenyl)methanamine (25 mg, 0.099 mmol) in THF/DMF (1.0/0.3 mL) was added. The reaction mixture was stirred at 65° C. overnight, then diluted with ethyl acetate. The organic layer was washed sequentially with 5% aqueous acetic acid (×2), saturated aqueous sodium bicarbonate (×2), and brine (×1). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to yield a crude product (40 mg). The crude was dissolved in DMSO and purified by reverse phase preparative HPLC to give the title compound (12.4 mg, 32% yield).

(505) .sup.1H NMR (300 MHz, DMSO-d.sub.6): δ 12.05 (brs, 1H), 9.30 (t, 1H), 8.88 (s, 1H), 8.16 (d, 1H), 7.76 (d, 2H), 7.54 (d, 2H), 7.32 (d, 1H), 7.27 (s, 1H), 4.57 (d, 2H), 3.08 (m, 1H), 1.78-1.66 (m, 4H), 1.51 (d, 1H), 1.20-0.96 (m, 5H).

(506) LC-MS: 398.0 (M+H).

(507) It is understood that the person skilled in the art will be able to prepare the compounds of the present invention using methods known in the art along with the general method of synthesis described herein.

ASSAYS

Assay Example 1

(508) Biochemical Inhibition Assay

(509) NAMPT Protein Purification

(510) Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-exclusion column by XTAL Biostructures.

(511) The NAMPT Enzymatic Reaction

(512) The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl.sub.2, and 1 mM THP) in 96-well V-bottom plates. The compound titrations were performed in a separate dilution plate by serially diluting the compounds in DMSO to make a 10× stock. Buffer A (89 μL) containing 33 nM of NAMPT protein was added to 1 μL of 100× compound plate containing controls (e.g. DMSO or blank). The compound and enzyme mix was incubated for 15 minutes at room temperature, then 10 μL of 10× substrate and co-factors in Buffer A were added to the test well to make a final concentration of 1 M NAM, 100 μM 5-Phospho-D-ribose 1-diphosphate (PRPP), and 2.5 mM Adenosine 5′-triphosphate (ATP). The reaction was allowed to proceed for 30 minutes at room temperature, then was quenched with the addition of 11 μL of a solution of formic acid and L-Cystathionine to make a final concentration of 1% formic acid and 10 μM L-Cystathionine. Background and signal strength was determined by addition (or non-addition) of a serial dilution of NMN to a pre-quenched enzyme and cofactor mix.

(513) Quantification of NMN

(514) A mass spectrometry-based assay was used to measure the NAMPT reaction product (NMN) and the internal control (L-Cystathionine). NMN and L-Cystathionine were detected using the services of Biocius Lifesciences with the RapidFire system. In short, the NMN and L-Cystathionine are bound to a graphitic carbon cartridge in 0.1% formic acid, eluted in 30% acetonitrile buffer, and injected into a Sciex 4000 mass spectrometer. The components of the sample were ionized with electrospray ionization and the positive ions were detected. The Q1 (parent ion) and Q3 (fragment ion) masses of NMN were 334.2 and 123.2, respectively. The Q1 and Q3 for L-Cystathionine were 223.1 and 134.1, respectively. The fragments are quantified and the analyzed by the following method.

(515) % Inhibitions are Determined Using this Method.

(516) First the NMN signal is normalized to the L-Cystathionine signal by dividing the NMN signal by the L-Cystathionine signal for each well. The signal from the background wells are averaged and subtracted from the test plates. The compound treated cells re then assayed for % inhibition by using this formula.
% Inh=100−100*x/y
wherein x denotes the average signal of the compound treated wells and y denotes the average signal of the DMSO treated wells.
IC50s are Determined Using Excel and this Formula.
IC50=10{circumflex over ( )}(LOG 10(X)+(((50−% Inh at Cmpd Concentration1)/(XX−YY)*(LOG 10(X)−LOG 10(Y))))
wherein X denotes the compound concentration 1, Y denotes the compound concentration 2, XX denotes the % inhibition at compound concentration 1 (X), and YY denotes the % inhibition at compound concentration 2 (Y).

(517) The NAMPT-inhibitor compounds of this invention have IC50 values that are preferably under 1 μM, more preferably under 0.1 μM, and most preferably under 0.01 μM. Results for the compounds are provided in Table 3.

Assay Example 2

(518) In-Vitro Cell Proliferation Assay

(519) A2780 cells were seeded in 96-well plates at 1×10.sup.3 cells/well in 180 μL of culture medium (10% FBS, 1% Pen/Strep Amphotecricin B, RPMI-1640) with and without the addition of either β-nicotinamide mononucleotide (NMN) or nicotinamide (NAM). After overnight incubation at 37° C. and 5% CO.sub.2, the compound titrations were performed in a separate dilution plate by serially diluting the compounds in DMSO to make a 1000× stock. The compounds were then further diluted to 10× final concentration in culture media, whereupon 20 μL of each dilution was added to the plated cells with controls (e.g. DMSO and blank) to make a final volume of 200 μL. The final DMSO concentration in each well was 0.1%. The plates were then incubated for 72 hours at 37° C. in a 5% CO.sub.2 incubator. The number of viable cells was then assessed using sulforhodamine B (SRB) assay. Cells were fixed at 4° C. for 1 hour with the addition of 50 μL 30% trichloroacetic acid (TCA) to make a final concentration of 6% TCA. The plates were washed four times with H.sub.2O and allowed to dry for at least 1 hour, whereupon 100 μL of a 4% SRB in 1% acetic acid solution was added to each well and incubated at room temperature for at least 30 minutes. The plates were then washed three times with 1% acetic acid, dried, and treated with 100 μL of 10 mM Tris-Base solution. The plates were then read in a microplate reader at an absorbance of 570 nm. Background was generated on a separate plate with media only.

(520) Method for Determining % Inhibition

(521) First, the signals from the background plate are averaged, then the background was subtracted from the test plates. The compound-treated cells were then assayed for % inhibition by using the following formula:
% Inh=100−100*x/y
wherein x denotes the average signal of the compound-treated cells and y denotes the average signal of the DMSO-treated cells.
Formula for Determining IC.sub.50 Values:
IC50=10{circumflex over ( )}(LOG 10(X)+(((50−% Inh at Cmpd Concentration1)/(XX−YY)*(LOG 10(X)−LOG 10(Y))))

(522) wherein X denotes the compound concentration 1, Y denotes the compound concentration 2, XX denotes the % inhibition at compound concentration 1 (X), and YY denotes the % inhibition at compound concentration 2 (Y).

(523) Specificity of Cytotoxicity.

(524) Inhibition of NAMPT could be reversed by the addition of NAM or NMN. The specificity of the compounds were determined via cell viability assay in the presence of the compound and either NAM or NMN. Percent inhibitions were determined using the method given above.

(525) The NAMPT-inhibitor compounds of this invention have IC50 values that are preferably under 1 M, more preferably under 0.1p M, and most preferably under 0.01 μM. Most preferable compounds of this invention are compounds that have both the enzymatic IC50-value and the A2780 IC 50-value under 1 M, more preferably both of the values are under 0.1 μM, and most preferably both of the values are under 0.01 μM. Results for the compounds are provided in Table 3.

(526) TABLE-US-00003 TABLE 3 Biochem A2780 IUPAC Name IC50 uM IC50 uM (E)-2-cyano-3-({4-[(5-fluoro-2- 0.0011 0.0030 methoxyphenyl)sulfamoyl]phenyl}methyl)-1-(pyridin-4-yl)guanidine 5-hydroxy-N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)-1H- 0.1-1   1-10 indole-2-carboxamide 5-hydroxy-N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]- 0.1-1   1-10 1H-indole-2-carboxamide 5-hydroxy-N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.1-1   1-10 1H-indole-2-carboxamide 5-hydroxy-N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.1442 0.1-1 1H-indole-2-carboxamide 5-hydroxy-N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}-1H- 0.1-1 >1.0 indole-2-carboxamide 5-N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)pyridine-2,5-   1-10 0.661 diamido 6-amino-N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)pyridine- 0.0142 0.275 3-carboxamide N-({4-[(2,3,6-trimethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0797 0.0663 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,3,6-trimethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0399 0.0667 c]pyridine-2-carboxamide N-({4-[(2,3-difluoro-6-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.204 0.0849 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2,3-difluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0820 0.2786 b]pyridine-5-carboxamide N-({4-[(2,3-dimethoxy-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.1462 0.0586 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,3-dimethoxy-5- 0.0152 0.007 methylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(2,3-dimethoxy-5- 0.0042 0.0156 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2,3-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.123 0.0833 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,3-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0117 0.0049 c]pyridine-2-carboxamide N-({4-[(2,3-dimethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0093 0.0136 c]pyridine-2-carboxamide N-({4-[(2,3-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0687 0.0249 a]pyridine-6-carboxamide N-({4-[(2,3-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0176 0.0776 a]pyrimidine-6-carboxamide N-({4-[(2,3-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0516 0.008 c]pyridine-2-carboxamide N-({4-[(2,3-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0433 0.00985 a]pyridine-6-carboxamide N-({4-[(2,3-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0041 0.0469 a]pyrimidine-6-carboxamide N-({4-[(2,4,5-trimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0313 0.0193 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,4,5-trimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0091 0.0141 c]pyridine-2-carboxamide N-({4-[(2,4,5-trimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00934 0.0141 a]pyridine-6-carboxamide N-({4-[(2,4,5-trimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0069 0.0240 a]pyrimidine-6-carboxamide N-({4-[(2,4,6-trimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.136 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,4,6-trimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0592 0.1-1 c]pyridine-2-carboxamide N-({4-[(2,4,6-trimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0288 0.1-1 a]pyrimidine-6-carboxamide N-({4-[(2,4-dichloro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.02 0.0147 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,4-dichloro-3- 0.0177 0.0162 methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(2,4-dichloro-3- 0.0311 0.013 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2,4-dichloro-3- 0.0066 0.0255 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2,4-dichloro-3- 0.0051 0.0067 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2,4-difluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0283 0.0281 a]pyridine-6-carboxamide N-({4-[(2,4-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.1744 0.0447 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,4-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0582 0.0151 a]pyridine-6-carboxamide N-({4-[(2,4-dimethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0045 0.0016 c]pyridine-2-carboxamide N-({4-[(2,4-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0612 0.0716 b]pyridine-5-carboxamide N-({4-[(2,4-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0218 0.024 c]pyridine-2-carboxamide N-({4-[(2,4-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0216 0.0321 a]pyridine-6-carboxamide N-({4-[(2,4-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0021 0.0492 a]pyrimidine-6-carboxamide N-({4-[(2,5-difluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.1-1 0.3921 b]pyridine-5-carboxamide N-({4-[(2,5-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0398 0.0248 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,5-dimethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0114 0.0063 c]pyridine-2-carboxamide N-({4-[(2,5-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0202 0.0128 a]pyridine-6-carboxamide N-({4-[(2,5-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0069 0.0457 a]pyrimidine-6-carboxamide N-({4-[(2,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0209 0.0172 b]pyridine-5-carboxamide N-({4-[(2,5-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0181 0.0239 c]pyridine-2-carboxamide N-({4-[(2,5-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0293 0.0154 a]pyridine-6-carboxamide N-({4-[(2,6-dichloro-3-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0108 0.0162 c]pyridine-2-carboxamide N-({4-[(2,6-dichloro-3- 0.0073 0.0560 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2,6-dichloro-3- 0.0044 0.0082 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2,6-dichlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.1795   1-10 b]pyridine-5-carboxamide N-({4-[(2,6-dichlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0447 0.0135 c]pyridine-2-carboxamide N-({4-[(2,6-dichlorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0124 0.0601 c]pyridine-2-carboxamide N-({4-[(2,6-dichlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0012 0.0188 a]pyridine-6-carboxamide N-({4-[(2,6-dichlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0134 0.1-1 a]pyrimidine-6-carboxamide N-({4-[(2,6-dichlorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0076 0.0182 c]pyridine-2-carboxamide N-({4-[(2,6-dimethoxy-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.1-1 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2,6-dimethoxy-4- 0.0050 0.0230 methylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(2,6-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.159 0.1-1 b]pyridine-5-carboxamide N-({4-[(2,6-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0323 0.1-1 c]pyridine-2-carboxamide N-({4-[(2-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0036 0.0114 b]pyridine-5-carboxamide N-({4-[(2-acetylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0057 0.0065 carboxamide N-({4-[(2-acetylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0025 0.0082 a]pyrimidine-6-carboxamide N-({4-[(2-butoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.176 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-butoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0311 0.0055 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-butoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0335 0.0665 c]pyridine-2-carboxamide N-({4-[(2-butoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0512 0.0062 a]pyridine-6-carboxamide N-({4-[(2-butoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0073 0.0738 a]pyrimidine-6-carboxamide N-({4-[(2-butoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0070 0.0063 c]pyridine-2-carboxamide N-({4-[(2-butoxy-5-chlorobenzene)sulfonyl]phenyl}methyl)-1H- 0.117 0.0737 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-butoxy-5-chlorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0156 0.0083 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-butoxy-5-chlorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0243 0.0663 c]pyridine-2-carboxamide N-({4-[(2-butoxy-5-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0110 0.0080 a]pyridine-6-carboxamide N-({4-[(2-butoxy-5-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0037 0.0628 a]pyrimidine-6-carboxamide N-({4-[(2-butoxy-5-chlorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0073 0.0100 c]pyridine-2-carboxamide N-({4-[(2-butoxy-6-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0088 0.0056 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-butoxy-6-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0256 0.0698 c]pyridine-2-carboxamide N-({4-[(2-butoxy-6-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0053 0.0069 a]pyridine-6-carboxamide N-({4-[(2-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0736 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0170 0.0611 c]pyridine-2-carboxamide N-({4-[(2-chloro-4-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0178 0.0634 c]pyridine-2-carboxamide N-({4-[(2-chloro-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0144 0.1-1 a]pyrimidine-6-carboxamide N-({4-[(2-chloro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0516 0.0877 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0093 0.0145 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-4- 0.0167 0.0114 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-chloro-4- 0.0065 0.0669 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2-chloro-4- 0.0027 0.0055 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.005 0.00278 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0080 0.0027 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0141 0.0142 c]pyridine-2-carboxamide N-({4-[(2-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0011 0.0009 a]pyridine-6-carboxamide N-({4-[(2-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0015 0.0007 a]pyrimidine-6-carboxamide N-({4-[(2-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0249 0.0016 c]pyridine-2-carboxamide N-({4-[(2-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0281 0.0121 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0163 0.0248 c]pyridine-2-carboxamide N-({4-[(2-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0210 0.0063 a]pyridine-6-carboxamide N-({4-[(2-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0105 0.0530 a]pyrimidine-6-carboxamide N-({4-[(2-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0042 0.0057 c]pyridine-2-carboxamide N-({4-[(2-chloro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0247 0.0668 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0110 0.0097 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-5-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0026 0.0206 c]pyridine-2-carboxamide N-({4-[(2-chloro-5- 0.0056 0.0027 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-chloro-5- 0.0061 0.0515 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2-chloro-5- 0.0049 0.0053 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0602 0.0659 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0188 0.0091 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0178 0.0149 c]pyridine-2-carboxamide N-({4-[(2-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0056 0.0046 a]pyridine-6-carboxamide N-({4-[(2-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0057 0.0225 a]pyrimidine-6-carboxamide N-({4-[(2-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0022 0.0049 c]pyridine-2-carboxamide N-({4-[(2-chloro-6-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.1142 0.0371 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chloro-6-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.1722 0.0766 a]pyridine-6-carboxamide N-({4-[(2-chloro-6-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0167 0.0214 c]pyridine-2-carboxamide N-({4-[(2-chloro-6- 0.0202 0.0258 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-chloro-6- 0.0027 0.0029 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0925   1-0.1 b]pyridine-5-carboxamide N-({4-[(2-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0241 0.0567 a]pyridine-6-carboxamide N-({4-[(2-chlorobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.0024 0.0066 2-carboxamide N-({4-[(2-cyanobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.131 0.1-1 b]pyridine-5-carboxamide N-({4-[(2-cyanobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0253 0.0629 c]pyridine-2-carboxamide N-({4-[(2-cyanobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0246 0.0635 carboxamide N-({4-[(2-cyanobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0156 0.0613 a]pyridine-6-carboxamide N-({4-[(2-cyanobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.0146 0.0676 2-carboxamide N-({4-[(2-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0863 0.0670 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0034 0.0018 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0077 0.0069 c]pyridine-2-carboxamide N-({4-[(2-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0314 0.0015 a]pyridine-6-carboxamide N-({4-[(2-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0071 0.0143 a]pyrimidine-6-carboxamide N-({4-[(2-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0038 0.0009 c]pyridine-2-carboxamide N-({4-[(2-ethoxy-6-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0170 0.0283 c]pyridine-2-carboxamide N-({4-[(2-ethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0493 0.0269 b]pyridine-5-carboxamide N-({4-[(2-ethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0659 0.006 carboxamide N-({4-[(2-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0203 0.00339 a]pyridine-6-carboxamide N-({4-[(2-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0010 0.0071 a]pyrimidine-6-carboxamide N-({4-[(2-ethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0084 0.013 b]pyridine-5-carboxamide N-({4-[(2-ethylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0054 0.0129 carboxamide N-({4-[(2-ethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine- 0.0302 0.0129 6-carboxamide N-({4-[(2-ethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0025 0.0249 a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0086 0.0563 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-3- 0.033 0.0135 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0197 0.0239 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0758 0.0070 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0063 0.0079 c]pyridine-2-carboxamide N-({4-[(2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0075 0.0033 a]pyridine-6-carboxamide N-({4-[(2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0032 0.0215 a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0107 0.0033 c]pyridine-2-carboxamide N-({4-[(2-fluoro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.1203 0.2067 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-4- 0.0413 0.0229 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0123 0.0253 c]pyridine-2-carboxamide N-({4-[(2-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0214 0.0247 a]pyridine-6-carboxamide N-({4-[(2-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0063 0.0614 a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.139 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0778 0.0144 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-fluoro-5-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0268 0.0637 c]pyridine-2-carboxamide N-({4-[(2-fluoro-5- 0.0047 0.0128 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-fluoro-5- 0.0104 0.0629 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2-fluoro-5-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0023 0.0128 c]pyridine-2-carboxamide N-({4-[(2-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0241 0.0716 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0059 0.0134 c]pyridine-2-carboxamide N-({4-[(2-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0068 0.0275 a]pyrimidine-6-carboxamide N-({4-[(2-fluoro-6- 0.0481 0.0264 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-fluoro-6-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0133 0.0142 c]pyridine-2-carboxamide N-({4-[(2-fluoro-6- 0.0914 0.0010 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-fluoro-6-propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0115 0.0293 c]pyridine-2-carboxamide N-({4-[(2-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0418 0.1-1 carboxamide N-({4-[(2-methanesulfonylbenzene)sulfonyl]phenyl}methyl)-1H- 0.2022 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-methanesulfonylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0542 0.1-1 c]pyridine-2-carboxamide N-({4-[(2-methoxy-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0563 0.0244 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-methoxy-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0133 0.0068 c]pyridine-2-carboxamide N-({4-[(2-methoxy-5- 0.0431 0.0117 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-methoxy-5- 0.0039 0.0072 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2-methoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0683 0.0618 b]pyridine-5-carboxamide N-({4-[(2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine- 0.0189 0.0265 2-carboxamide N-({4-[(2-methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0265 0.0153 a]pyridine-6-carboxamide N-({4-[(2-methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0039 0.0747 a]pyrimidine-6-carboxamide N-({4-[(2-methyl-4-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0644 0.0794 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(2-methyl-4-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0305 0.0221 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-methyl-4-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0225 0.0596 c]pyridine-2-carboxamide N-({4-[(2-methyl-4- 0.0092 0.0133 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(2-methyl-4- 0.0100 0.0518 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(2-methyl-4- 0.0129 0.0017 propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2-methylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0926   1-0.1 b]pyridine-5-carboxamide N-({4-[(2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0152 0.0433 carboxamide N-({4-[(2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0669 0.0912 a]pyridine-6-carboxamide N-({4-[(2-phenoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.1-1 0.1-1 b]pyridine-5-carboxamide N-({4-[(2-phenoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine- 0.0204   1-10 2-carboxamide N-({4-[(2-phenoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0636 0.0607 a]pyridine-6-carboxamide N-({4-[(2-phenoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0085 0.1-1 a]pyrimidine-6-carboxamide N-({4-[(3,4-dichlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0067 0.0055 b]pyridine-5-carboxamide N-({4-[(3,4-dichlorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0104 0.0048 c]pyridine-2-carboxamide N-({4-[(3,4-dichlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0015 0.0017 a]pyrimidine-6-carboxamide N-({4-[(3,4-difluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0542 0.0289 b]pyridine-5-carboxamide N-({4-[(3,4-difluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0168 0.013 c]pyridine-2-carboxamide N-({4-[(3,4-difluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0041 0.0363 a]pyrimidine-6-carboxamide N-({4-[(3,4-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0206 0.0056 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3,4-dimethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0062 0.0038 c]pyridine-2-carboxamide N-({4-[(3,4-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.012 0.00251 a]pyridine-6-carboxamide N-({4-[(3,4-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0029 0.0073 a]pyrimidine-6-carboxamide N-({4-[(3,4-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0051 0.0034 b]pyridine-5-carboxamide N-({4-[(3,4-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0150 0.003 c]pyridine-2-carboxamide N-({4-[(3,4-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0111 0.00297 a]pyridine-6-carboxamide N-({4-[(3,4-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0011 0.0016 a]pyrimidine-6-carboxamide N-({4-[(3,5-dichlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0067 0.0021 b]pyridine-5-carboxamide N-({4-[(3,5-dichlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.001 0.0004 c]pyridine-2-carboxamide N-({4-[(3,5-dichlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00549 0.00128 a]pyridine-6-carboxamide N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.008 0.007 b]pyridine-5-carboxamide N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.006 0.0015 a]pyridine-6-carboxamide N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.002 0.003 a]pyrimidine-6-carboxamide N-({4-[(3,5-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0026 0.0022 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3,5-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0044 0.0015 c]pyridine-2-carboxamide N-({4-[(3,5-dimethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0027 0.0017 c]pyridine-2-carboxamide N-({4-[(3,5-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0032 0.0015 a]pyridine-6-carboxamide N-({4-[(3,5-dimethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0024 0.0016 a]pyrimidine-6-carboxamide N-({4-[(3,5-dimethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0013 0.0009 c]pyridine-2-carboxamide N-({4-[(3,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0104 0.0061 b]pyridine-5-carboxamide N-({4-[(3,5-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0167 0.0028 c]pyridine-2-carboxamide N-({4-[(3,5-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00676 0.00317 a]pyridine-6-carboxamide N-({4-[(3,5-dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0017 0.0020 a]pyrimidine-6-carboxamide N-({4-[(3-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0100 0.0129 b]pyridine-5-carboxamide N-({4-[(3-acetylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0176 0.008 carboxamide N-({4-[(3-acetylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0125 0.00637 a]pyridine-6-carboxamide N-({4-[(3-acetylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0018 0.0105 a]pyrimidine-6-carboxamide N-({4-[(3-butoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0384 0.0675 b]pyridine-5-carboxamide N-({4-[(3-butoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0115 0.0216 c]pyridine-2-carboxamide N-({4-[(3-butoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0123 0.0695 carboxamide N-({4-[(3-butoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0047 0.0180 a]pyridine-6-carboxamide N-({4-[(3-butoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0033 0.0387 c]pyridine-2-carboxamide N-({4-[(3-chloro-2-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0109 0.0128 c]pyridine-2-carboxamide N-({4-[(3-chloro-2-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0024 0.0176 a]pyrimidine-6-carboxamide N-({4-[(3-chloro-2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0192 0.0623 c]pyridine-2-carboxamide N-({4-[(3-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0369 0.0161 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0625 0.0120 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0026 0.0016 c]pyridine-2-carboxamide N-({4-[(3-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0257 0.0050 a]pyridine-6-carboxamide N-({4-[(3-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0043 0.0265 a]pyrimidine-6-carboxamide N-({4-[(3-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0572 0.0071 c]pyridine-2-carboxamide N-({4-[(3-chloro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0040 0.0036 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0107 0.0021 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-4-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0073 0.0018 c]pyridine-2-carboxamide N-({4-[(3-chloro-4- 0.0018 0.0018 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-chloro-4- 0.0050 0.0016 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(3-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0061 0.0019 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0083 0.0025 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0528 0.0017 c]pyridine-2-carboxamide N-({4-[(3-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0018 0.0012 a]pyrimidine-6-carboxamide N-({4-[(3-chloro-4-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0051 0.0010 c]pyridine-2-carboxamide N-({4-[(3-chloro-4-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0079 0.00958 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-4-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0740 0.0078 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-4-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0049 0.0119 c]pyridine-2-carboxamide N-({4-[(3-chloro-4- 0.0065 0.0060 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(3-chloro-4- 0.0039 0.0024 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-chloro-4-propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0151 0.0174 c]pyridine-2-carboxamide N-({4-[(3-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0133 0.0060 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0099 0.0014 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0178 0.0031 c]pyridine-2-carboxamide N-({4-[(3-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0039 0.0003 a]pyridine-6-carboxamide N-({4-[(3-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0024 0.0029 a]pyrimidine-6-carboxamide N-({4-[(3-chloro-5-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0014 0.0006 c]pyridine-2-carboxamide N-({4-[(3-chloro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0093 0.0025 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0170 0.0025 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-chloro-5-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0265 0.0015 c]pyridine-2-carboxamide N-({4-[(3-chloro-5- 0.0092 0.0015 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(3-chloro-5- 0.0013 0.0008 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-chloro-5- 0.0041 0.0011 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(3-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0062 0.0026 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0269 0.0018 c]pyridine-2-carboxamide N-({4-[(3-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0013 0.0008 c]pyridine-2-carboxamide N-({4-[(3-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0064 0.002 a]pyridine-6-carboxamide N-({4-[(3-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0048 0.0023 a]pyrimidine-6-carboxamide N-({4-[(3-chloro-5-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0045 0.0016 c]pyridine-2-carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.007 0.006 b]pyridine-5-carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0039 0.013 b]pyridine-2-carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0060 0.0033 carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00908 0.00307 a]pyridine-6-carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0013 0.0012 a]pyrimidine-6-carboxamide N-({4-[(3-cyanobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0185 0.00954 b]pyridine-5-carboxamide N-({4-[(3-cyanobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0121 0.0113 c]pyridine-2-carboxamide N-({4-[(3-cyanobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0154 0.0126 carboxamide N-({4-[(3-cyanobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0059 0.0192 a]pyrimidine-6-carboxamide N-({4-[(3-cyanobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.0035 0.0056 2-carboxamide N-({4-[(3-ethoxy-2-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0312 0.0116 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-ethoxy-2-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0175 0.0227 c]pyridine-2-carboxamide N-({4-[(3-ethoxy-2-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0050 0.0062 a]pyridine-6-carboxamide N-({4-[(3-ethoxy-2-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0040 0.0197 a]pyrimidine-6-carboxamide N-({4-[(3-ethoxy-2-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0037 0.0129 c]pyridine-2-carboxamide N-({4-[(3-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0261 0.012 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0824 0.0044 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0110 0.0072 c]pyridine-2-carboxamide N-({4-[(3-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0170 0.006 a]pyridine-6-carboxamide N-({4-[(3-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0003 0.0078 a]pyrimidine-6-carboxamide N-({4-[(3-ethoxy-4-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0033 0.0031 c]pyridine-2-carboxamide N-({4-[(3-ethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0146 0.0190 b]pyridine-5-carboxamide N-({4-[(3-ethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0077 0.0035 c]pyridine-2-carboxamide N-({4-[(3-ethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0068 0.0110 carboxamide N-({4-[(3-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0050 0.0031 a]pyridine-6-carboxamide N-({4-[(3-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0021 0.0067 a]pyrimidine-6-carboxamide N-({4-[(3-ethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0032 0.0029 c]pyridine-2-carboxamide N-({4-[(3-ethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0070 0.0071 b]pyridine-5-carboxamide N-({4-[(3-ethylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0087 0.0065 carboxamide N-({4-[(3-ethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine- 0.00483 0.00323 6-carboxamide N-({4-[(3-ethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0038 0.0041 a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.121 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0324 0.0063 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0166 0.0309 c]pyridine-2-carboxamide N-({4-[(3-fluoro-2- 0.0769 0.0650 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(3-fluoro-2- 0.0289 0.1-1 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0133 0.0125 c]pyridine-2-carboxamide N-({4-[(3-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0469 0.0718 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0576 0.0132 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0132 0.0307 c]pyridine-2-carboxamide N-({4-[(3-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0469 0.0132 a]pyridine-6-carboxamide N-({4-[(3-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0081 0.0656 a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0071 0.0214 c]pyridine-2-carboxamide N-({4-[(3-fluoro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0430 0.0060 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-4-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0022 0.0068 c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- 0.00595 0.00289 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(3-fluoro-4- 0.0017 0.0083 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0117 0.0056 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0140 0.0033 c]pyridine-2-carboxamide N-({4-[(3-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0133 0.00378 a]pyridine-6-carboxamide N-({4-[(3-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0023 0.0063 a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-4-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0116 0.0065 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-4-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0309 0.0104 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0068 0.0118 c]pyridine-2-carboxamide N-({4-[(3-fluoro-4- 0.0221 0.0044 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(3-fluoro-4- 0.0027 0.0033 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-fluoro-4-propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0037 0.0081 c]pyridine-2-carboxamide N-({4-[(3-fluoro-5-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0044 0.0063 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-5-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0174 0.0033 c]pyridine-2-carboxamide N-({4-[(3-fluoro-5- 0.0016 0.0033 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0095 0.0056 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0083 0.0018 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0034 0.0032 c]pyridine-2-carboxamide N-({4-[(3-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0027 0.0006 a]pyridine-6-carboxamide N-({4-[(3-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0015 0.0054 a]pyrimidine-6-carboxamide N-({4-[(3-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0010 0.0006 c]pyridine-2-carboxamide N-({4-[(3-fluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0339 0.0253 b]pyridine-5-carboxamide N-({4-[(3-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0058 0.0145 carboxamide N-({4-[(3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0221 0.0122 a]pyridine-6-carboxamide N-({4-[(3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0019 0.0221 a]pyrimidine-6-carboxamide N-({4-[(3-hydroxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.005 0.0070 a]pyridine-6-carboxamide N-({4-[(3-methanesulfonylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0060 0.0068 c]pyridine-2-carboxamide N-({4-[(3- 0.0256 0.016 methanesulfonylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(3-methanesulfonylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0017 0.0035 c]pyridine-2-carboxamide N-({4-[(3-methoxy-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0036 0.0034 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(3-methoxy-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0079 0.0030 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-methoxy-4-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0046 0.0031 c]pyridine-2-carboxamide N-({4-[(3-methoxy-4- 0.0013 0.0017 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-methoxy-4- 0.0027 0.0015 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(3-methoxy-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0096 0.0028 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-methoxy-5-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0022 0.0016 c]pyridine-2-carboxamide N-({4-[(3-methoxy-5- 0.0053 0.0016 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(3-methoxy-5- 0.0016 0.0013 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(3-methoxy-5- 0.0024 0.0008 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(3-methoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0209 0.0100 b]pyridine-5-carboxamide N-({4-[(3-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine- 0.0035 0.0069 2-carboxamide N-({4-[(3-methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00497 0.00245 a]pyridine-6-carboxamide N-({4-[(3-methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0020 0.0124 a]pyrimidine-6-carboxamide N-({4-[(3-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0023 0.0053 carboxamide N-({4-[(3-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00812 0.00639 a]pyridine-6-carboxamide N-({4-[(3-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0019 0.0091 a]pyrimidine-6-carboxamide N-({4-[(3-phenylbenzene)sulfonyl]phenyl}methyl)-1,3-benzothiazole-6- 0.0185   1-10 carboxamide N-({4-[(3-phenylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0023 0.0119 c]pyridine-2-carboxamide N-({4-[(3-phenylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0137 0.0234 carboxamide N-({4-[(3-phenylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0122 0.0068 a]pyridine-6-carboxamide N-({4-[(3-phenylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0009 0.0033 a]pyrimidine-6-carboxamide N-({4-[(3-phenylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.0045 0.0100 2-carboxamide N-({4-[(3-phenylpropane)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.014 0.078 c]pyridine-2-carboxamide N-({4-[(3-propoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0304 0.041 b]pyridine-5-carboxamide N-({4-[(3-propoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0102 0.0122 c]pyridine-2-carboxamide N-({4-[(3-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine- 0.0101 0.0252 2-carboxamide N-({4-[(3-propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0042 0.0063 a]pyridine-6-carboxamide N-({4-[(3-propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0048 0.0075 a]pyrimidine-6-carboxamide N-({4-[(3-propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0040 0.0122 c]pyridine-2-carboxamide N-({4-[(3-sulfamoylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0301 0.1-1 b]pyridine-5-carboxamide N-({4-[(3-sulfamoylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0103 0.0546 a]pyridine-6-carboxamide N-({4-[(3-sulfamoylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0020 0.0121 c]pyridine-2-carboxamide N-({4-[(3-tert-butylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0093 0.0070 c]pyridine-2-carboxamide N-({4-[(3-tert-butylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0097 0.0032 a]pyridine-6-carboxamide N-({4-[(3-tert-butylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- <0.00065 0.0012 a]pyrimidine-6-carboxamide N-({4-[(3-tert-butylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0105 0.0091 c]pyridine-2-carboxamide N-({4-[(4,5-difluoro-2- 0.0281 0.0259 methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(4,5-difluoro-2- 0.0281 0.0068 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4,5-difluoro-2- 0.0119 0.0249 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0289 0.0037 b]pyridine-5-carboxamide N-({4-[(4-acetylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0052 0.0065 a]pyrimidine-6-carboxamide N-({4-[(4-butoxy-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0709 0.0688 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-butoxy-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0800 0.0625 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-butoxy-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0160 0.0648 c]pyridine-2-carboxamide N-({4-[(4-butoxy-2- 0.0100 0.0224 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-butoxy-2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0033   1.0-0.1 c]pyridine-2-carboxamide N-({4-[(4-butoxy-3-chlorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0045 0.0111 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-butoxy-3-chlorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0178 0.0124 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-butoxy-3-chlorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0047 0.0100 c]pyridine-2-carboxamide N-({4-[(4-butoxy-3-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0041 0.0076 a]pyridine-6-carboxamide N-({4-[(4-butoxy-3-chlorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0048 0.0125 c]pyridine-2-carboxamide N-({4-[(4-butoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0536 0.0134 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-butoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0123 0.0139 c]pyridine-2-carboxamide N-({4-[(4-butoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0062 0.0031 a]pyridine-6-carboxamide N-({4-[(4-butoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0012 0.0031 a]pyrimidine-6-carboxamide N-({4-[(4-butoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0047 0.0126 c]pyridine-2-carboxamide N-({4-[(4-butoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0275 0.0225 b]pyridine-5-carboxamide N-({4-[(4-butoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0084 0.0171 c]pyridine-2-carboxamide N-({4-[(4-butoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0062 0.0130 carboxamide N-({4-[(4-butoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0038 0.0028 a]pyridine-6-carboxamide N-({4-[(4-butoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0036 0.0103 c]pyridine-2-carboxamide N-({4-[(4-butylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0712 0.0684 b]pyridine-5-carboxamide N-({4-[(4-butylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0146 0.0358 c]pyridine-2-carboxamide N-({4-[(4-butylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0181 0.0265 carboxamide N-({4-[(4-butylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine- 0.0057 0.0076 6-carboxamide N-({4-[(4-butylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0053 0.0107 a]pyrimidine-6-carboxamide N-({4-[(4-butylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.0029 0.0260 2-carboxamide N-({4-[(4-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0112 0.0004 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0072 0.0051 c]pyridine-2-carboxamide N-({4-[(4-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0041 0.0007 a]pyridine-6-carboxamide N-({4-[(4-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0020 0.0045 a]pyrimidine-6-carboxamide N-({4-[(4-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0024 <0.0004 c]pyridine-2-carboxamide N-({4-[(4-chloro-2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0085 0.0248 c]pyridine-2-carboxamide N-({4-[(4-chloro-2- 0.0187 0.0126 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-chloro-2- 0.0033 0.0247 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0775 0.0587 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0249 0.0647 c]pyridine-2-carboxamide N-({4-[(4-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0066 0.0539 a]pyrimidine-6-carboxamide N-({4-[(4-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0185 0.0065 c]pyridine-2-carboxamide N-({4-[(4-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00722 0.00724 a]pyridine-6-carboxamide N-({4-[(4-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0019 0.0089 a]pyrimidine-6-carboxamide N-({4-[(4-chloro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0127 0.0130 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-chloro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0055 0.0036 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-3-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0059 0.0060 c]pyridine-2-carboxamide N-({4-[(4-chloro-3- 0.0135 0.006 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-chloro-3- 0.0027 0.0052 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-chloro-3- 0.0026 0.0023 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0288 0.022 b]pyridine-5-carboxamide N-({4-[(4-chlorobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0049 0.0142 carboxamide N-({4-[(4-chlorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0025 0.0236 a]pyrimidine-6-carboxamide N-({4-[(4-cyanobenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0284 0.0208 b]pyridine-5-carboxamide N-({4-[(4-cyanobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0111 0.0251 c]pyridine-2-carboxamide N-({4-[(4-cyanobenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0053 0.0309 carboxamide N-({4-[(4-cyanobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0160 0.0141 a]pyridine-6-carboxamide N-({4-[(4-cyclohexylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0178 0.0117 a]pyridine-6-carboxamide N-({4-[(4-cyclohexylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0058 0.0077 a]pyrimidine-6-carboxamide N-({4-[(4-cyclohexylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0034 0.0129 c]pyridine-2-carboxamide N-({4-[(4-ethoxy-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.1083 0.0667 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-ethoxy-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0092 0.0126 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-ethoxy-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0216 0.0274 c]pyridine-2-carboxamide N-({4-[(4-ethoxy-2- 0.0066 0.0111 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-ethoxy-2- 0.0117 0.0607 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-ethoxy-2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0012 0.0132 c]pyridine-2-carboxamide N-({4-[(4-ethoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0095 0.0052 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-ethoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.0205 0.0054 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-ethoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0127 0.0018 a]pyridine-6-carboxamide N-({4-[(4-ethoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0009 0.0031 a]pyrimidine-6-carboxamide N-({4-[(4-ethoxy-3-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0089 0.0036 c]pyridine-2-carboxamide N-({4-[(4-ethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0151 0.0084 b]pyridine-5-carboxamide N-({4-[(4-ethoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0025 0.0071 carboxamide N-({4-[(4-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0045 0.0029 a]pyridine-6-carboxamide N-({4-[(4-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0020 0.0061 a]pyrimidine-6-carboxamide N-({4-[(4-ethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0021 0.0040 c]pyridine-2-carboxamide N-({4-[(4-ethylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0050 0.007 carboxamide N-({4-[(4-ethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine- 0.0165 0.00736 6-carboxamide N-({4-[(4-ethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0012 0.0062 a]pyrimidine-6-carboxamide N-({4-[(4-fluoro-2,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0373 0.0459 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-fluoro-2,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0514 0.0128 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2,5-dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0176 0.0242 c]pyridine-2-carboxamide N-({4-[(4-fluoro-2,5- 0.0440 0.011 dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-fluoro-2,5- 0.0058 0.0294 dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-fluoro-2,5- 0.0042 0.0136 dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.159 0.0742 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0127 0.0160 c]pyridine-2-carboxamide N-({4-[(4-fluoro-2- 0.0193 0.00705 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-fluoro-2- 0.0191 0.0736 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0788 0.0983 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0187 0.0651 c]pyridine-2-carboxamide N-({4-[(4-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0130 0.1-1 a]pyrimidine-6-carboxamide N-({4-[(4-fluoro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0239 0.0115 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-fluoro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0278 0.0054 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-3-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0078 0.0070 c]pyridine-2-carboxamide N-({4-[(4-fluoro-3- 0.0197 0.0067 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-fluoro-3- 0.0049 0.0108 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-fluoro-3-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0090 0.0031 c]pyridine-2-carboxamide N-({4-[(4-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0050 0.0083 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0132 0.006 c]pyridine-2-carboxamide N-({4-[(4-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0235 0.00714 a]pyridine-6-carboxamide N-({4-[(4-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0022 0.0096 a]pyrimidine-6-carboxamide N-({4-[(4-methanesulfonylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0293 0.0238 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4- 0.105 0.0247 methanesulfonylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide N-({4-[(4-methoxy-2,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0368 0.0236 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-methoxy-2,5- 0.0123 0.0128 dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(4-methoxy-2,5- 0.0281 0.006 dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-methoxy-2,5- 0.0052 0.0130 dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-methoxy-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.029 0.0555 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-methoxy-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0216 0.0351 c]pyridine-2-carboxamide N-({4-[(4-methoxy-2- 0.0024 0.0679 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-methoxy-3,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.005 0.00185 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(4-methoxy-3,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0516 0.0017 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-methoxy-3,5- 0.0056 0.0018 dimethylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(4-methoxy-3,5- 0.0146 0.0014 dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-methoxy-3,5- 0.0027 0.0013 dimethylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-methoxy-3,5- 0.0098 0.0009 dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4-methoxy-3- 0.0141 0.00532 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(4-methoxy-3- 0.0022 0.0055 methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(4-methoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0209 0.0143 b]pyridine-5-carboxamide N-({4-[(4-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine- 0.0055 0.006 2-carboxamide N-({4-[(4-methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.00974 0.00866 a]pyridine-6-carboxamide N-({4-[(4-methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0027 0.0207 a]pyrimidine-6-carboxamide N-({4-[(4-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.1208 0.006 carboxamide N-({4-[(4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0176 0.012 a]pyridine-6-carboxamide N-({4-[(4-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0043 0.0194 a]pyrimidine-6-carboxamide N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)-1,3-benzothiazole-6- 0.0207 0.1-1 carboxamide N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4- 0.0320 0.0117 b]pyridine-5-carboxamide N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0310 0.0133 c]pyridine-2-carboxamide N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- 0.0037 0.0069 carboxamide N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0032 0.0076 a]pyrimidine-6-carboxamide N-({4-[(4-phenylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.0030 0.0106 2-carboxamide N-({4-[(4-phenylbutane)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.216 0.0715 c]pyridine-2-carboxamide N-({4-[(4-propoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.0053 0.0067 c]pyridine-2-carboxamide N-({4-[(4-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine- 0.0495 0.012 2-carboxamide N-({4-[(4-propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0061 0.0019 a]pyridine-6-carboxamide N-({4-[(4-propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0022 0.0061 a]pyrimidine-6-carboxamide N-({4-[(4-propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0043 0.0081 c]pyridine-2-carboxamide N-({4-[(5-acetyl-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0277 0.0275 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-acetyl-2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0072 0.0038 c]pyridine-2-carboxamide N-({4-[(5-acetyl-2- 0.0379 0.0127 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-acetyl-2- 0.0172 0.0548 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(5-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0022 0.0005 a]pyridine-6-carboxamide N-({4-[(5-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0019 0.0033 a]pyrimidine-6-carboxamide N-({4-[(5-chloro-2-ethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0027 0.0005 c]pyridine-2-carboxamide N-({4-[(5-chloro-2- 0.014 0.1682 hydroxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-chloro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0492 0.0081 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-chloro-2- 0.0191 0.0032 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-chloro-2- 0.0055 0.0061 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(5-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0227 0.0139 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0058 0.0078 c]pyridine-2-carboxamide N-({4-[(5-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0019 0.0037 a]pyridine-6-carboxamide N-({4-[(5-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0031 0.0043 a]pyrimidine-6-carboxamide N-({4-[(5-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0048 0.0066 c]pyridine-2-carboxamide N-({4-[(5-chloro-2-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0492 0.0251 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-chloro-2-propoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0075 0.0012 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-chloro-2-propoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0080 0.0093 c]pyridine-2-carboxamide N-({4-[(5-chloro-2- 0.0080 0.0032 propoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-chloro-2-propoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0057 0.0012 c]pyridine-2-carboxamide N-({4-[(5-cyano-2- 0.0146 0.0119 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0390 0.0151 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0022 0.0124 c]pyridine-2-carboxamide N-({4-[(5-fluoro-2- 0.022 0.00665 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-fluoro-2- 0.0073 0.0261 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(5-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.0020 0.0008 c]pyridine-2-carboxamide N-({4-[(5-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.0204 0.0597 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)furo[2,3- 0.0143 0.0249 c]pyridine-2-carboxamide N-({4-[(5-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0126 0.0229 a]pyridine-6-carboxamide N-({4-[(5-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.0027 0.0351 a]pyrimidine-6-carboxamide N-({4-[(5-tert-butyl-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.0456 0.0216 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(5-tert-butyl-2- 0.0218 0.0101 methoxybenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(5-tert-butyl-2- 0.029 0.00677 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6- carboxamide N-({4-[(5-tert-butyl-2- 0.0098 0.0077 methoxybenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6- carboxamide N-({4-[(6-chloro-2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)- 0.112 0.1-1 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[(6-chloro-2-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)- 0.0065 0.0071 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(6-chloro-2-fluoro-3- 0.0219 0.0293 methylbenzene)sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2- carboxamide N-({4-[(6-chloro-2-fluoro-3- 0.0077 0.0068 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4-sulfonyl]phenyl}methyl)-1H- 0.0282 0.0556 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4-sulfonyl]phenyl}methyl)-1H- 0.0169 0.0131 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- 0.0116 0.0140 sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- 0.0140 0.0064 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- 0.0022 0.0115 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[1-(3-chlorophenyl)-1H-pyrazole-4- 0.0041 0.0139 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[1-(4-fluorophenyl)-1H-pyrazole-4-sulfonyl]phenyl}methyl)-1H- 0.0184 0.0066 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[1-(4-fluorophenyl)-1H-pyrazole-4- 0.0069 0.0074 sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2-carboxamide N-({4-[1-(4-fluorophenyl)-1H-pyrazole-4- 0.0045 0.0062 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[1-(propan-2-yl)-1H-pyrazole-4- 0.008 0.0027 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazole-4- 0.0299 0.0278 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[1-methyl-5-(trifluoromethyl)-1H-pyrazole-4- 0.0534 0.0434 sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[1-methyl-5-(trifluoromethyl)-1H-pyrazole-4- 0.0040 0.0679 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4-sulfonyl]phenyl}methyl)-1H- 0.0271 0.0609 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4-sulfonyl]phenyl}methyl)-1H- 0.0192 0.0232 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- 0.0119 0.0504 sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- 0.0229 0.0128 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- 0.0010 0.0069 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[2-(3-fluorophenyl)-1,3-thiazole-4- 0.0066 0.0244 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[2-(benzenesulfonyl)ethyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.023 0.166 c]pyridine-2-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5-sulfonyl]phenyl}methyl)-1H- 0.0079 0.0059 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5-sulfonyl]phenyl}methyl)-1H- 0.0190 0.0035 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5- 0.0258 0.012 sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5- 0.0229 0.0036 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(dimethylamino)pyrimidine-5- 0.0080 0.0017 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[2-(morpholin-4-yl)pyridine-3-sulfonyl]phenyl}methyl)furo[2,3- 0.0325 0.0605 c]pyridine-2-carboxamide N-({4-[2-(morpholin-4-yl)pyridine-3- 0.0312 0.1-1 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5-sulfonyl]phenyl}methyl)-1H- 0.0028 0.0009 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5-sulfonyl]phenyl}methyl)-1H- 0.0060 0.0005 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- 0.0024 0.0004 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- 0.0029 0.0009 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[2-(pyrrolidin-1-yl)-1,3-thiazole-5- 0.0015 0.0007 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2-a]pyridine-6- 0.0497 0.0330 sulfonyl]phenyl}methyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2-a]pyridine-6- 0.0212 0.0119 sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2-a]pyridine-6- 0.0362 0.0070 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[2-(trifluoromethyl)imidazo[1,2-a]pyridine-6- 0.0031 0.0039 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[2-(trifluoromethyl)pyridine-3-sulfonyl]phenyl}methyl)furo[2,3- 0.0304 0.0279 c]pyridine-2-carboxamide N-({4-[3-chloro-2-(morpholin-4-yl)pyridine-4- 0.0085 0.0018 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2-sulfonyl]phenyl}methyl)-1H- 0.0283 0.0118 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2-sulfonyl]phenyl}methyl)furo[2,3- 0.0139 0.0061 c]pyridine-2-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2- 0.0197 0.0032 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2- 0.0087 0.0130 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[4-(trifluoromethyl)pyridine-2- 0.0036 0.0030 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[5-(dimethylamino)pyrazine-2- 0.016 0.0036 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3-sulfonyl]phenyl}methyl)-1,3- 0.0092 0.1-1 benzothiazole-6-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.0179 0.0040 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.0139 0.0020 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3-sulfonyl]phenyl}methyl)furo[2,3- 0.0228 0.0049 c]pyridine-2-carboxamide N-({4-[5-(pyrrolidin-1-yl)pyridine-3- 0.004 0.0005 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2-sulfonyl]phenyl}methyl)-1H- 0.1-1 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2-sulfonyl]phenyl}methyl)furo[2,3- 0.0370 0.1-1 c]pyridine-2-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- 0.0463 0.0326 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- 0.0059 0.0708 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[5-(trifluoromethyl)pyridine-2- 0.0235 0.1-1 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[5-(trifluoromethyl)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.011 0.004 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[5-(trifluoromethyl)pyridine-3- 0.009 0.0013 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(1H-pyrazol-1-yl)pyridine-3- 0.004 0.0019 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2-sulfonyl]phenyl}methyl)-1H- 0.0178 0.0410 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2-sulfonyl]phenyl}methyl)-1H- 0.0160 0.0127 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- 0.0050 0.0427 sulfonyl]phenyl}methyl)furo[2,3-c]pyridine-2-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- 0.0043 0.0057 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(3,4-difluorophenyl)pyridine-2- 0.0022 0.0132 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[6-(4-methylpiperazin-1-yl)pyridine-3-sulfonyl]phenyl}methyl)- 0.006 0.0006 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(dimethylamino)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.0305 0.0033 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[6-(dimethylamino)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.0209 0.0034 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(dimethylamino)pyridine-3-sulfonyl]phenyl}methyl)furo[2,3- 0.003 0.0018 c]pyridine-2-carboxamide N-({4-[6-(dimethylamino)pyridine-3- 0.0449 0.0027 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(dimethylamino)pyridine-3- 0.0027 0.0059 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[6-(dimethylamino)pyridine-3- 0.001 0.0006 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.0057 0.0032 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3-sulfonyl]phenyl}methyl)-1H- 0.0096 0.0015 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3-sulfonyl]phenyl}methyl)furo[2,3- 0.002 0.0009 c]pyridine-2-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- 0.0090 0.0015 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3- 0.0011 0.0033 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[6-(morpholin-4-yl)pyridine-3-sulfonyl]phenyl}methyl)thieno[2,3- 0.0041 0.0007 c]pyridine-2-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2-sulfonyl]phenyl}methyl)-1H- 0.0242 0.0111 pyrazolo[3,4-b]pyridine-5-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2-sulfonyl]phenyl}methyl)furo[2,3- 0.0050 0.0031 c]pyridine-2-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- 0.0087 0.0015 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- 0.0114 0.0204 sulfonyl]phenyl}methyl)imidazo[1,2-a]pyrimidine-6-carboxamide N-({4-[6-(trifluoromethyl)pyridine-2- 0.0021 0.0022 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-({4-[6-(trifluoromethyl)pyridine-3- 0.0076 0.0067 sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2-carboxamide N-(1,3-benzothiazol-6-ylmethyl)-4-[(3- 0.0100 >10 chlorobenzene)sulfonyl]benzamide N-[(4-{[2-(2,2,2-trifluoroethoxy)-4- 0.009 0.0010 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[2-(2,2,2-trifluoroethoxy)-4- 0.007 0.0012 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-(benzyloxy)-5- 0.1-1 0.1-1 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[2-(benzyloxy)-5- 0.1303 0.0259 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[2-(benzyloxy)-5- 0.0332 0.1-1 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-(dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.1-1 0.1-1 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2- 0.1-1   1-10 (dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[2- >0.1667 0.1-1 (dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2- 0.1-1   1-10 (dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2- 0.1-1 0.1-1 (dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0520 0.0612 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0185 0.0067 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0133 0.0260 c]pyridine-2-carboxamide N-[(4-{[2-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0037 0.0396 a]pyrimidine-6-carboxamide N-[(4-{[2-(methylsulfamoyl)benzene]sulfonyl}phenyl)methyl]-1H- >0.167 >10 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-(methylsulfamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0513 0.0740 c]pyridine-2-carboxamide N-[(4-{[2- 0.0304   1-10 (methylsulfamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-(morpholin-4-ylmethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0694 0.0465 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-(morpholin-4- 0.136 0.0342 ylmethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[2-(morpholin-4- 0.0145 0.1-1 ylmethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[2-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0086 0.0146 c]pyridine-2-carboxamide N-[(4-{[2- 0.0024 0.0115 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0194 0.0593 c]pyridine-2-carboxamide N-[(4-{[2- 0.0341 0.0579 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2- 0.0100 0.1-1 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2,4-bis(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0816 0.0562 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2,4-bis(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0401 0.0140 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2,4- 0.0530 0.0637 bis(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[2,4- 0.2202 0.0532 bis(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2,4- 0.0188 0.0964 bis(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2,4-bis(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0215 0.0043 c]pyridine-2-carboxamide N-[(4-{[2-chloro-3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0365 0.0384 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-chloro-3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0364 0.0088 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-chloro-3- 0.0184 0.0279 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[2-chloro-3- 0.0024 0.0246 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-chloro-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.114 0.0869 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-chloro-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.1269 0.0254 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-chloro-4- 0.0184 0.0644 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-chloro-5-(hydroxymethyl)benzene]sulfonyl}phenyl)methyl]- 0.0083 0.0262 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-chloro-5-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]- 0.0531 0.0120 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-chloro-5- 0.0080 0.0125 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-chloro-5- 0.0139 0.0141 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[2-chloro-5- 0.0070 0.0141 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-fluoro-3-(propan-2- 0.0078 0.0040 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[2-fluoro-3-(propan-2- 0.0018 0.0070 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[2-fluoro-3-(propan-2- 0.0047 0.0066 yloxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[2-fluoro-3- 0.0098 0.0133 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.0389 0.0344 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- 0.0184 0.008 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- 0.00844 0.0128 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- 0.0022 0.0190 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[2-fluoro-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0802 0.0281 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-fluoro-4- 0.0156 0.0157 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-fluoro-4- 0.0202 0.0423 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-methoxy-3- 0.0219 0.0148 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-methoxy-3- 0.0094 0.0128 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- 0.0242 0.0094 yl)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- 0.0065 0.006 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- 0.021 0.00359 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- 0.0032 0.0087 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[2-methoxy-4- 0.1200 0.0281 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[2-methoxy-4- 0.0264 0.00984 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-methoxy-4- 0.0044 0.0224 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-methoxy-4- 0.01 0.0022 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]- 0.0892 0.0294 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-methoxy-5-(propan-2- 0.0154 0.0124 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5-(propan-2- 0.0352 0.0064 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[2-methoxy-5- 0.0926 0.0246 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[2-methoxy-5- 0.0481 0.0066 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5- 0.0677 0.0144 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-methoxy-5- <0.00065 0.0058 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-methoxy-5- 0.0068 0.0036 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.0271 0.0235 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- 0.0062 0.006 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- 0.00799 0.0036 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1- 0.0015 0.0031 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[2-methyl-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.1-1 0.0746 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[2-methyl-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0305 0.0253 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-methyl-4- 0.0345 0.0631 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[2-methyl-4- 0.0247 0.0166 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[2-methyl-4- 0.0071 0.0511 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[2-methyl-4- 0.0103 0.0242 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0097 0.0074 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0075 0.0091 c]pyridine-2-carboxamide N-[(4-{[3-(1H-pyrazol-1- 0.0048 0.0062 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0015 0.0001 c]pyridine-2-carboxamide N-[(4-{[3-(2,2,2- 0.0072 0.0120 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[3-(2,2,2- 0.0150 0.0059 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-(2,2,2- 0.0055 0.0114 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0285 0.0342 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0322 0.0143 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0148 0.0677 c]pyridine-2-carboxamide N-[(4-{[3-(2- 0.0157 0.0106 methylpropoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-(2- 0.0039 0.0132 methylpropoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(2- 0.0032 0.0252 methylpropoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0179 0.1-1 yl)benzene]sulfonyl}phenyl)methyl]-1,3-benzothiazole-6-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0253 0.0053 yl)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5- carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0132 0.0016 yl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.1-1 0.1-1 yl)benzene]sulfonyl}phenyl)methyl]-5-hydroxy-1H-indole-2- carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0071 0.0035 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0072 0.0008 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0018 0.0041 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(3,5-dimethyl-1H-pyrazol-1- 0.0031 0.0015 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[3-(4- 0.0151 0.0340 fluorophenoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-(4- 0.0026 0.0656 fluorophenoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-(5-methyl-1,2,4-oxadiazol-3- 0.0079 0.0032 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-(5-methyl-1,2,4-oxadiazol-3- 0.0028 0.0023 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(5-methyl-1,2,4-oxadiazol-3- 0.0033 0.0010 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[3-(cyclopentylcarbamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0333 0.033 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3- 0.0066 0.0226 (cyclopentylcarbamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3- 0.0103 0.0162 (cyclopentylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- 0.0047 0.0483 (cyclopentylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3- 0.0048 0.0138 (cyclopentylcarbamoyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(diethylcarbamoyl)-5-fluorobenzene]sulfonyl}phenyl)methyl]- 0.0093 0.0033 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(diethylcarbamoyl)-5- 0.0103 0.0038 fluorobenzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[3-(diethylcarbamoyl)-5- 0.0047 0.0168 fluorobenzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(difluoromethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0028 0.0030 c]pyridine-2-carboxamide N-[(4-{[3- 0.0021 0.0050 (difluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3- 0.0020 0.0032 (dimethylsulfamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3- 0.0020 0.0112 (dimethylsulfamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(ethanesulfonyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0170 0.0155 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(ethanesulfonyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0027 0.0032 c]pyridine-2-carboxamide N-[(4-{[3- 0.0135 0.0060 (ethanesulfonyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- 0.0027 0.0645 (ethanesulfonyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(ethanesulfonyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0028 0.0054 c]pyridine-2-carboxamide N-[(4-{[3-(ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0060 0.0064 c]pyridine-2-carboxamide N-[(4-{[3- 0.0031 0.0655 (ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(methoxymethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0387 0.0394 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(methoxymethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0202 0.0128 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(methoxymethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0185 0.0134 c]pyridine-2-carboxamide N-[(4-{[3- 0.0067 0.0068 (methoxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- 0.0032 0.0138 (methoxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(methoxymethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0026 0.0067 c]pyridine-2-carboxamide N-[(4-{[3-(methylcarbamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0081 0.0143 c]pyridine-2-carboxamide N-[(4-{[3- 0.0037 0.1-1 (methylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]-1,3- 0.0401   1-10 benzothiazole-6-carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0167 0.0130 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0207 0.0106 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0084 0.0017 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0050 0.0056 c]pyridine-2-carboxamide N-[(4-{[3-(morpholin-4- 0.0077 0.0033 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-(morpholin-4- 0.0027 0.0135 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0040 0.0019 c]pyridine-2-carboxamide N-[(4-{[3-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0036 0.0032 c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1,3- 0.0210 0.1-1 benzothiazole-6-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0536 0.0140 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0144 0.0033 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0113 0.0127 c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0114 0.0034 a]pyridine-6-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0051 0.0114 a]pyrimidine-6-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0012 0.0057 a]pyrimidine-6-carboxamide N-[(4-{[3-(piperidin-1-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0167 0.0136 c]pyridine-2-carboxamide N-[(4-{[3-(piperidin-1- 0.0091 0.0035 ylmethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-(piperidin-1- 0.0019 0.0306 ylmethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0139 0.0063 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0045 0.007 c]pyridine-2-carboxamide N-[(4-{[3-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0124 0.00349 a]pyridine-6-carboxamide N-[(4-{[3-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0029 0.0053 a]pyrimidine-6-carboxamide N-[(4-{[3-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0461 0.0245 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0126 0.0144 c]pyridine-2-carboxamide N-[(4-{[3-(propan-2- 0.0023 0.0105 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-(propane-1- 0.0023 0.0862 sulfonamido)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(propane-1- 0.0015 0.0032 sulfonamido)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[3-(pyrimidin-2-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0219 0.0038 a]pyridine-6-carboxamide N-[(4-{[3-(pyrimidin-2-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0032 0.0130 a]pyrimidine-6-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1,3- 0.0088   1-10 benzothiazole-6-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0171 0.0128 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0134 0.0028 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0082 0.0074 c]pyridine-2-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0136 0.0016 a]pyridine-6-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0025 0.0041 a]pyrimidine-6-carboxamide N-[(4-{[3-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0019 0.0025 c]pyridine-2-carboxamide N-[(4-{[3-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0204 0.0071 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0034 0.0067 c]pyridine-2-carboxamide N-[(4-{[3- 0.00873 0.00318 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- 0.0025 0.0027 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1,3- 0.006 0.5481 benzothiazole-6-carboxamide N-[(4-{[3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0607 0.0104 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0054 0.0048 c]pyridine-2-carboxamide N-[(4-{[3- 0.00842 0.00172 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3- 0.0027 0.0030 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-chloro-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0843 0.0264 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-chloro-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0133 0.0077 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-chloro-4- 0.0079 0.0062 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-chloro-4- 0.0029 0.0012 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-chloro-4- 0.0028 0.0018 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-chloro-4- 0.0030 0.0023 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-chloro-5- 0.0084 0.0017 (diethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-chloro-5- 0.0009 0.0012 (diethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-chloro-5- 0.0023 0.0008 (diethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-chloro-5- 0.0058 0.0014 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-chloro-5- 0.0034 0.0114 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-chloro-5- 0.0033 0.0008 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-chloro-5-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0078 0.00273 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-chloro-5-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0199 0.0027 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-chloro-5- 0.0044 0.0004 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.0131 0.0033 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1- 0.0173 0.005 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1- 0.00537 0.00341 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-fluoro-4-(2,2,2- 0.0103 0.0223 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- 0.0069 0.0238 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[3-fluoro-4-(2,2,2- 0.0150 0.008 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- 0.0044 0.0073 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4-(2,2,2- 0.0046 0.0235 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-fluoro-4- 0.0123 0.0112 (methylsulfanyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[3-fluoro-4- 0.0056 0.0027 (methylsulfanyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-4- 0.0022 0.0020 (methylsulfanyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]- 0.0174 0.0137 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-fluoro-4-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]- 0.0262 0.0205 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- 0.0100 0.0156 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- 0.0084 0.0063 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-4- 0.0040 0.0118 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4- 0.0115 0.0115 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0103 0.0130 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4- 0.0092 0.0137 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-fluoro-4- 0.0402 0.0044 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-4- 0.0041 0.0069 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-4- 0.0088 0.0072 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- 0.008 0.00482 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- 0.0056 0.0019 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- 0.0074 0.0061 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[3-fluoro-5-(2,2,2- 0.0019 0.0015 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5-(2,2,2- 0.0029 0.0035 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-fluoro-5-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]- 0.0112 0.00949 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-fluoro-5-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]- 0.0132 0.0070 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(2- 0.0103 0.0129 methylpropoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[3-fluoro-5-(2- 0.0113 0.003 methylpropoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[3-fluoro-5-(2- 0.0031 0.0034 methylpropoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5-(2- 0.0048 0.0075 methylpropoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-fluoro-5-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]- 0.004 0.0008 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5-(morpholin-4- 0.003 0.0006 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-fluoro-5-(pyrrolidin-1- 0.0039 0.0022 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[3-fluoro-5-(pyrrolidin-1- 0.0031 0.0020 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[3-fluoro-5-(pyrrolidin-1- 0.0012 0.0027 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[3-fluoro-5-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0112 0.00345 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[3-fluoro-5-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0262 0.0036 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-fluoro-5- 0.0074 0.0050 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[3-fluoro-5- 0.0059 0.0011 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[3-fluoro-5- 0.0102 0.0031 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-(1-cyanocyclopentyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0601 0.0189 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(1- 0.0080 0.0060 cyanocyclopentyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-(1- 0.0107 0.0030 cyanocyclopentyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(1- 0.0032 0.0047 cyanocyclopentyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-(1H-imidazol-1- <0.00065 0.0122 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[4-(1H-imidazol-1- 0.0190 0.0137 ylmethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[4-(1H-imidazol-1- 0.0053 0.0122 ylmethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0123 0.0075 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0041 0.0073 c]pyridine-2-carboxamide N-[(4-{[4-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0263 0.0162 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0127 0.0094 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(2-methylpropoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0094 0.0116 c]pyridine-2-carboxamide N-[(4-{[4-(2- 0.0022 0.0027 methylpropoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(2- 0.0055 0.0052 methylpropoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-(2- 0.0040 0.0103 methylpropoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-(4-ethoxyphenyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.009 0.0090 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(4-methylpiperazin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.004 0.0013 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(4-methylpiperazin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.003 0.0008 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(4-methylpiperazin-1- 0.001 0.0005 yl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{[4-(4-methylpiperazin-1- 0.001 0.0002 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[4-(4-methylpiperazin-1- 0.001 0.0003 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[4-(difluoromethyl)-3- 0.0082 0.0279 fluorobenzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[4-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0266 0.0128 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0225 0.0068 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0049 0.0066 c]pyridine-2-carboxamide N-[(4-{[4-(ethoxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0027 0.0052 a]pyrimidine-6-carboxamide N-[(4-{[4-(ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.103 0.0968 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0145 0.0141 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0045 0.0067 c]pyridine-2-carboxamide N-[(4-{[4- 0.0120 0.0063 (ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4- 0.0226 0.0878 (ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-(ethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0015 0.0033 c]pyridine-2-carboxamide N-[(4-{[4-(hydroxymethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0049 0.0062 c]pyridine-2-carboxamide N-[(4-{[4- 0.0142 0.0129 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-(hydroxymethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0038 0.0066 c]pyridine-2-carboxamide N-[(4-{[4-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.00445 0.00247 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0046 0.0025 c]pyridine-2-carboxamide N-[(4-{[4-(morpholin-4- 0.0035 0.0009 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[4-(morpholin-4- 0.0017 0.0040 yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[4-(morpholin-4-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0016 0.0015 c]pyridine-2-carboxamide N-[(4-{[4-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0119 0.0080 c]pyridine-2-carboxamide N-[(4-{[4-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0146 0.00666 a]pyridine-6-carboxamide N-[(4-{[4-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.0017 0.0081 a]pyrimidine-6-carboxamide N-[(4-{[4-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0080 0.0066 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0068 0.0057 c]pyridine-2-carboxamide N-[(4-{[4-(propan-2- 0.0043 0.0032 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[4-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.006 0.0045 pyrazolo[3,4-b]pyridine-6-carboxamide N-[(4-{[4-(pyrrolidin-1-yl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- 0.003 0.0014 a]pyridine-6-carboxamide N-[(4-{[4-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.0346 0.0223 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0094 0.0277 c]pyridine-2-carboxamide N-[(4-{[4- 0.0050 0.0176 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.0199 0.0194 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3- 0.0087 0.0198 c]pyridine-2-carboxamide N-[(4-{[4- 0.0060 0.0235 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-chloro-2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.147 0.0783 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-chloro-2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0422 0.0174 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-chloro-2- 0.0098 0.0254 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-chloro-2- 0.0198 0.0085 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-chloro-2- 0.0079 0.0684 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-chloro-2- 0.0070 0.0096 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-chloro-3- 0.0060 0.0069 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-chloro-3- 0.00984 0.00357 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-chloro-3- 0.0028 0.0043 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-2-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]- 0.0254 0.0033 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-fluoro-2-(propan-2- 0.0156 0.0139 yloxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[4-fluoro-2-(propan-2- 0.0222 0.0021 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[4-fluoro-2-(propan-2- 0.0035 0.0150 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[4-fluoro-2-(propan-2- 0.0050 0.0016 yloxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[4-fluoro-2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.112 0.109 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-fluoro-2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0270 0.0141 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-fluoro-2- 0.0040 0.0150 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-fluoro-2- 0.0187 0.1-1 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-2- 0.0064 0.0143 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- 0.01 0.0147 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- 0.0103 0.0065 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- 0.0087 0.0255 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[4-fluoro-3-(2,2,2- 0.0024 0.0065 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-3-(2,2,2- 0.0033 0.0118 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-fluoro-3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0394 0.0138 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[4-fluoro-3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.0164 0.0043 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-fluoro-3- 0.0082 0.0072 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-fluoro-3- 0.0040 0.0017 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[4-fluoro-3- 0.0080 0.0032 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-fluoro-3- 0.0040 0.0028 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[4-methoxy-2- 0.0868 0.0628 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[4-methoxy-2- 0.0804 0.0130 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[4-methoxy-2- 0.0146 0.0152 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[4-methoxy-2- 0.0070 0.0657 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[4-methoxy-2- 0.0217 0.0130 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[5-(diethylcarbamoyl)-2-fluorobenzene]sulfonyl}phenyl)methyl]- 0.0384 0.0262 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[5-chloro-2-(2,2,2- 0.001 0.0003 trifluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[5-chloro-2-(2,2- 0.005 0.0005 difluoroethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[5-chloro-2-(2,2- 0.002 0.0003 difluoroethoxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[5-chloro-2-(prop-2-yn-1- 0.007 0.0014 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6- carboxamide N-[(4-{[5-chloro-2-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]- 0.0678 0.0271 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[5-chloro-2-(propan-2- 0.0091 0.0121 yloxy)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2- carboxamide N-[(4-{[5-chloro-2-(propan-2- 0.0047 0.0146 yloxy)benzene]sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6- carboxamide N-[(4-{[5-fluoro-2-(hydroxymethyl)benzene]sulfonyl}phenyl)methyl]- 0.109 0.1-1 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{[5-fluoro-2-(hydroxymethyl)benzene]sulfonyl}phenyl)methyl]- 0.0169 0.0675 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[5-fluoro-2- 0.0229 0.0670 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]furo[2,3-c]pyridine- 2-carboxamide N-[(4-{[5-fluoro-2- 0.0104 0.0650 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyridine-6-carboxamide N-[(4-{[5-fluoro-2- 0.0129 0.1-1 (hydroxymethyl)benzene]sulfonyl}phenyl)methyl]imidazo[1,2- a]pyrimidine-6-carboxamide N-[(4-{[5-fluoro-2-(hydroxymethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.0077 0.0249 c]pyridine-2-carboxamide N-[(4-{[5-hydroxy-2- 0.0219 0.0679 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-[(4-{[5-hydroxy-2- 0.0064 0.0115 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]furo[2,3- c]pyridine-2-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3-thiazole-5-sulfonyl}phenyl)methyl]- 0.0036 0.0015 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3-thiazole-5- 0.0048 0.0009 sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3-thiazole-5- 0.0033 0.0004 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3-thiazole-5- 0.0018 0.0009 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{2-[ethyl(methyl)amino]-1,3-thiazole-5- 0.0029 0.0012 sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2-carboxamide N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2-a]azepine-3- 0.0316 0.0123 sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2-a]azepine-3- 0.0060 0.0057 sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2-a]azepine-3- 0.0011 0.0287 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{5H,6H,7H,8H,9H-imidazo[1,2-a]azepine-3- 0.0030 0.0008 sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3-sulfonyl}phenyl)methyl]-1H- 0.0033 0.0008 pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3-sulfonyl}phenyl)methyl]-1H- 0.0132 0.0014 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- 0.0012 0.0004 sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- 0.0053 0.0004 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- 0.0016 0.0004 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{6-chloroimidazo[1,2-a]pyridine-3- 0.0012 0.0004 sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2-carboxamide N-[(4-{8-oxatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.021 0.00752 sulfonyl}phenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-[(4-{8-oxatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.0124 0.0128 sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{8-oxatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.0017 0.0029 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.0035 0.0032 sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.0087 0.012 sulfonyl}phenyl)methyl]furo[2,3-c]pyridine-2-carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.0018 0.0020 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyrimidine-6-carboxamide N-[(4-{8-thiatricyclo[7.4.0.0.sup.2,.sup.7]trideca-1(13),2,4,6,9,11-hexaene-6- 0.0014 0.0043 sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2-carboxamide N-{[4-({3-[(2- 0.0193 0.0458 methylpropyl)carbamoyl]benzene}sulfonyl)phenyl]methyl}-1H- pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-({3-[(2- 0.0169 0.0263 methylpropyl)carbamoyl]benzene}sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-({3-[(2- 0.0070 0.0456 methylpropyl)carbamoyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({3-[(2- 0.0052 0.0145 methylpropyl)carbamoyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-({3- 0.0047 0.0062 [(dimethylamino)methyl]benzene}sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-({3- 0.0044 0.0660 [(dimethylamino)methyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({3-[(morpholin-4-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}- 0.1235 0.1-1 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-({3-[(propan-2- 0.0151 0.0157 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- carboxamide N-{[4-({3-[(propan-2- 0.0222 0.0504 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine- 6-carboxamide N-{[4-({3-[(propan-2- 0.0070 0.0658 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({3-[(propan-2- 0.0027 0.0067 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- carboxamide N-{[4-({3-[2- 0.0118 0.0058 (dimethylamino)ethoxy]benzene}sulfonyl)phenyl]methyl}furo[2,3- c]pyridine-2-carboxamide N-{[4-({3-[2-(dimethylamino)ethyl]benzene}sulfonyl)phenyl]methyl}- 0.0292 0.0223 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-({3-[2- 0.0035 0.1-1 (dimethylamino)ethyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({3-[2- 0.0025 0.0016 (dimethylamino)ethyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3- c]pyridine-2-carboxamide N-{[4-({3-[2-(morpholin-4-yl)ethoxy]benzene}sulfonyl)phenyl]methyl}- 0.0649 0.0126 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-({3-[2-(morpholin-4- 0.0068 0.0034 yl)ethoxy]benzene}sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- carboxamide N-{[4-({3-[2-(morpholin-4- 0.0031 0.0247 yl)ethoxy]benzene}sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine- 6-carboxamide N-{[4-({3-[2-(morpholin-4- 0.0030 0.0015 yl)ethoxy]benzene}sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- carboxamide N-{[4-({4-[(1R)-1- 0.0285 0.0122 hydroxybutyl]benzene}sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- carboxamide N-{[4-({4-[(1R)-1- 0.0048 0.0142 hydroxybutyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({4- 0.0033 0.0246 [(dimethylamino)methyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({4-[(pyrrolidin-1-yl)carbonyl]benzene}sulfonyl)phenyl]methyl}- 0.0158 0.0093 1H-pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-({4-[(pyrrolidin-1- 0.0015 0.0014 yl)carbonyl]benzene}sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- carboxamide N-{[4-({4-[(pyrrolidin-1- 0.0037 0.0017 yl)carbonyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- carboxamide N-{[4-({4-[2- 0.0021 0.0008 (dimethylamino)ethyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyridine-6-carboxamide N-{[4-({4-[2- 0.0020 0.0181 (dimethylamino)ethyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({4-[2-(pyrrolidin-1-yl)ethoxy]benzene}sulfonyl)phenyl]methyl}- 0.003 0.0023 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-({4-fluoro-3-[(propan-2- 0.0852 0.0631 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- b]pyridine-5-carboxamide N-{[4-({4-fluoro-3-[(propan-2- 0.0077 0.0854 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}imidazo[1,2- a]pyrimidine-6-carboxamide N-{[4-({4-fluoro-3-[(propan-2- 0.0213 0.0068 yl)carbamoyl]benzene}sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- carboxamide N-{[4-(1,3-thiazole-2-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0198 0.0786 carboxamide N-{[4-(1,3-thiazole-2-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.021 0.0994 carboxamide N-{[4-(1,3-thiazole-2-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.0144 0.0751 carboxamide N-{[4-(1,4-dimethyl-1H-imidazole-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0607 0.1-1 c]pyridine-2-carboxamide N-{[4-(1,4-dimethyl-1H-imidazole-2- 0.1-1 0.0954 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(1,4-dimethyl-1H-imidazole-2- 0.0316   1-10 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(1,5-dimethyl-1H-imidazole-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0574 0.0659 c]pyridine-2-carboxamide N-{[4-(1,5-dimethyl-1H-imidazole-2- 0.0309 0.0731 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(1,5-dimethyl-1H-imidazole-2- 0.0329   1-10 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(1-benzothiophene-7-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0099 0.0128 b]pyridine-5-carboxamide N-{[4-(1-benzothiophene-7-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine- 0.0049 0.0139 2-carboxamide N-{[4-(1-benzothiophene-7-sulfonyl)phenyl]methyl}thieno[2,3- 0.0015 0.0015 c]pyridine-2-carboxamide N-{[4-(1H-indole-7-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0147 0.0432 b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-1,3-benzodiazole-6-sulfonyl)phenyl]methyl} 0.0040 0.0338 imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}-1,3- 0.0098   1-10 benzothiazole-6-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}-1H- 0.0203 0.0064 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}-1H- 0.0031 0.0015 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}furo[2,3- 0.0092 0.0036 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0125 0.0030 a]pyridine-6-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0042 0.0103 a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-4-sulfonyl)phenyl]methyl}thieno[2,3- 0.0011 0.0008 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-5-sulfonyl)phenyl]methyl}-1H- 0.0054 0.00273 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-indazole-5-sulfonyl)phenyl]methyl}-1H- 0.0057 0.0031 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-5-sulfonyl)phenyl]methyl}furo[2,3- 0.0033 0.0035 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0040 0.0016 a]pyridine-6-carboxamide N-{[4-(1-methyl-1H-indazole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0017 0.0049 a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-5-sulfonyl)phenyl]methyl}thieno[2,3- 0.0015 0.0016 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}-1H- 0.004 0.0030 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}-1H- 0.0051 0.0033 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}furo[2,3- 0.0047 0.0034 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0050 0.0039 a]pyridine-6-carboxamide N-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0016 0.0050 a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}thieno[2,3- 0.0023 0.0011 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7-sulfonyl)phenyl]methyl}-1H- 0.0918 0.0869 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-indazole-7-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0371 0.0111 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7-sulfonyl)phenyl]methyl}furo[2,3- 0.0115 0.0275 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indazole-7-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0287 0.0275 a]pyridine-6-carboxamide N-{[4-(1-methyl-1H-indazole-7-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0233 0.1-1 a]pyrimidine-6-carboxamide N-{[4-(1-methyl-1H-indazole-7-sulfonyl)phenyl]methyl}thieno[2,3- 0.0045 0.0104 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-indole-2-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0140 0.0132 b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-indole-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.0052 0.0034 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}-1H- 0.182 0.1-1 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-methyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}furo[2,3- 0.0168 0.0654 c]pyridine-2-carboxamide N-{[4-(1-methyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0082 0.1-1 a]pyrimidine-6-carboxamide N-{[4-(1-propyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}-1H- 0.008 0.0070 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(1-propyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0149 0.0059 c]pyridine-2-carboxamide N-{[4-(1-propyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}furo[2,3- 0.0057 0.0064 c]pyridine-2-carboxamide N-{[4-(1-propyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0049 0.0052 a]pyridine-6-carboxamide N-{[4-(1-propyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}thieno[2,3- 0.0019 0.0016 c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1,4-benzodioxine-6- 0.0055 0.0062 sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1,4-benzodioxine-6- 0.0002 0.0005 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7-sulfonyl)phenyl]methyl}-1H- 0.0248 0.0147 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7-sulfonyl)phenyl]methyl}-1H- 0.0140 0.0038 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7-sulfonyl)phenyl]methyl}furo[2,3- 0.0060 0.0071 c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- 0.0125 0.0064 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7- 0.0021 0.0258 sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6-carboxamide N-{[4-(2,3-dihydro-1-benzofuran-7-sulfonyl)phenyl]methyl}thieno[2,3- 0.0022 0.0030 c]pyridine-2-carboxamide N-{[4-(2,6-dimethoxypyridine-3-sulfonyl)phenyl]methyl}-1H- 0.0307 0.0020 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2,6-dimethoxypyridine-3-sulfonyl)phenyl]methyl}furo[2,3- 0.0066 0.011 c]pyridine-2-carboxamide N-{[4-(2,6-dimethoxypyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0433 0.0092 a]pyridine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-4-sulfonyl)phenyl]methyl}-1H- 0.047 0.0884 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2H-1,3-benzodioxole-4-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0205 0.0118 c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-4-sulfonyl)phenyl]methyl}furo[2,3- 0.0258 0.0266 c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0071 0.0130 a]pyridine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0029 0.0933 a]pyrimidine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-4-sulfonyl)phenyl]methyl}thieno[2,3- 0.0033 0.0072 c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-5-sulfonyl)phenyl]methyl}-1H- 0.0482 0.0074 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2H-1,3-benzodioxole-5-sulfonyl)phenyl]methyl}furo[2,3- 0.0053 0.0087 c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0107 0.00533 a]pyridine-6-carboxamide N-{[4-(2H-1,3-benzodioxole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0030 0.0117 a]pyrimidine-6-carboxamide N-{[4-(2-methyl-1,3-thiazole-4-sulfonyl)phenyl]methyl}-1H- 0.0828 0.0207 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2-methyl-1,3-thiazole-4-sulfonyl)phenyl]methyl}furo[2,3- 0.0367 0.0690 c]pyridine-2-carboxamide N-{[4-(2-methyl-1,3-thiazole-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0286   1-10 a]pyrimidine-6-carboxamide N-{[4-(2-methyl-2H-indazole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0133 0.0058 a]pyridine-6-carboxamide N-{[4-(2-methyl-2H-indazole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0012 0.0082 a]pyrimidine-6-carboxamide N-{[4-(2-methyl-2H-indazole-5-sulfonyl)phenyl]methyl}thieno[2,3- 0.0055 0.0033 c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6-sulfonyl)phenyl]methyl}-1H- 0.0147 0.0070 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(2-methyl-2H-indazole-6-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0025 0.0032 c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6-sulfonyl)phenyl]methyl}furo[2,3- 0.0034 0.0028 c]pyridine-2-carboxamide N-{[4-(2-methyl-2H-indazole-6-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0019 0.0017 a]pyridine-6-carboxamide N-{[4-(2-methyl-2H-indazole-6-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0012 0.0061 a]pyrimidine-6-carboxamide N-{[4-(2-methyl-2H-indazole-6-sulfonyl)phenyl]methyl}thieno[2,3- 0.0014 0.0015 c]pyridine-2-carboxamide N-{[4-(2-methylpyridine-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.1045 0.1356 b]pyridine-5-carboxamide N-{[4-(2-methylpyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.1803 0.0240 c]pyridine-2-carboxamide N-{[4-(2-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0208 0.1-1 a]pyrimidine-6-carboxamide N-{[4-(2-methylpyridine-3-sulfonyl)phenyl]methyl}thieno[2,3- 0.0154 0.0119 c]pyridine-2-carboxamide N-{[4-(4-methylpyridine-2-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine- 0.0192 0.0114 2-carboxamide N-{[4-(4-methylpyridine-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.1-1 0.2714 b]pyridine-5-carboxamide N-{[4-(4-methylpyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.2599 0.0258 c]pyridine-2-carboxamide N-{[4-(4-methylpyridine-3-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine- 0.0252 0.062 2-carboxamide N-{[4-(4-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0665 0.0658 a]pyridine-6-carboxamide N-{[4-(4-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0191 0.1-1 a]pyrimidine-6-carboxamide N-{[4-(4-methylpyridine-3-sulfonyl)phenyl]methyl}thieno[2,3- 0.0292 0.0225 c]pyridine-2-carboxamide N-{[4-(4-methylthiophene-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0124 0.0125 a]pyridine-6-carboxamide N-{[4-(5-chloro-3-methylpyridine-2-sulfonyl)phenyl]methyl}-1H- 0.0625 0.0753 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(5-chloro-3-methylpyridine-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0099 0.0165 c]pyridine-2-carboxamide N-{[4-(5-chloro-3-methylpyridine-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0188 0.0080 a]pyridine-6-carboxamide N-{[4-(5-chloro-3-methylpyridine-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0022 0.0220 a]pyrimidine-6-carboxamide N-{[4-(5-chloro-3-methylpyridine-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.0039 0.0072 c]pyridine-2-carboxamide N-{[4-(5-chloropyridine-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0238 0.0062 b]pyridine-5-carboxamide N-{[4-(5-chloropyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0200 0.0036 c]pyridine-2-carboxamide N-{[4-(5-chloropyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0244 0.0032 a]pyridine-6-carboxamide N-{[4-(5-fluoro-6-methylpyridine-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0062 0.0124 c]pyridine-2-carboxamide N-{[4-(5-fluoro-6-methylpyridine-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.0083 0.0071 c]pyridine-2-carboxamide N-{[4-(5-fluoropyridine-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0792 0.0254 b]pyridine-5-carboxamide N-{[4-(5-fluoropyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0713 0.0136 c]pyridine-2-carboxamide N-{[4-(5-fluoropyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0278 0.0137 a]pyridine-6-carboxamide N-{[4-(5-fluoropyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0067 0.0564 a]pyrimidine-6-carboxamide N-{[4-(5-fluoropyridine-3-sulfonyl)phenyl]methyl}thieno[2,3- 0.0097 0.0064 c]pyridine-2-carboxamide N-{[4-(5-methoxypyridine-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0079 0.0316 c]pyridine-2-carboxamide N-{[4-(5-methoxypyridine-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0229 0.0173 a]pyridine-6-carboxamide N-{[4-(5-methoxypyridine-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.0071 0.0193 c]pyridine-2-carboxamide N-{[4-(5-methoxypyridine-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0414 0.0167 b]pyridine-5-carboxamide N-{[4-(5-methoxypyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0090 0.0034 a]pyridine-6-carboxamide N-{[4-(5-methoxypyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0016 0.0258 a]pyrimidine-6-carboxamide N-{[4-(5-methoxypyridine-3-sulfonyl)phenyl]methyl}thieno[2,3- 0.0090 0.0016 c]pyridine-2-carboxamide N-{[4-(5-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0368 0.0071 a]pyridine-6-carboxamide N-{[4-(5-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0022 0.0124 a]pyrimidine-6-carboxamide N-{[4-(5-methylpyridine-3-sulfonyl)phenyl]methyl}thieno[2,3- 0.0060 0.0025 c]pyridine-2-carboxamide N-{[4-(5-methylthiophene-2-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0223 0.0347 b]pyridine-5-carboxamide N-{[4-(6-methoxynaphthalene-2-sulfonyl)phenyl]methyl}-1H- 0.0099 0.0051 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(6-methoxynaphthalene-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0030 0.0036 c]pyridine-2-carboxamide N-{[4-(6-methoxynaphthalene-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0027 0.0018 a]pyridine-6-carboxamide N-{[4-(6-methoxynaphthalene-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.0015 0.0033 c]pyridine-2-carboxamide N-{[4-(6-methoxypyridine-2-sulfonyl)phenyl]methyl}furo[2,3- 0.0025 0.0032 c]pyridine-2-carboxamide N-{[4-(6-methoxypyridine-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0052 0.0013 a]pyridine-6-carboxamide N-{[4-(6-methoxypyridine-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0022 0.0059 a]pyrimidine-6-carboxamide N-{[4-(6-methylpyrazine-2-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0349 0.0312 b]pyridine-5-carboxamide N-{[4-(6-methylpyrazine-2-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine- 0.0209 0.0097 2-carboxamide N-{[4-(6-methylpyrazine-2-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0010 0.0525 a]pyrimidine-6-carboxamide N-{[4-(6-methylpyrazine-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.0048 0.0051 c]pyridine-2-carboxamide N-{[4-(6-methylpyridine-2-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine- 0.0128 0.0125 2-carboxamide N-{[4-(6-methylpyridine-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0241 0.0213 b]pyridine-5-carboxamide N-{[4-(6-methylpyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0557 0.0130 c]pyridine-2-carboxamide N-{[4-(6-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0215 0.0139 a]pyridine-6-carboxamide N-{[4-(6-methylpyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0059 0.0555 a]pyrimidine-6-carboxamide N-{[4-(6-methylpyridine-3-sulfonyl)phenyl]methyl}thieno[2,3- 0.0220 0.0063 c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-[1,3]thiazolo[5,4-c]pyridine-2- 0.220 >10 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1,6-naphthyridine-2- 2.85 >10 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine-3- 1.91 2.06 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.007 0.0088 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6- 0.002 0.057 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}quinoline-6-carboxamide 0.108 >10 N-{[4-(cyclohexanesulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine- 0.005 0.0176 2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5-sulfonyl)phenyl]methyl}-1H- 0.0386 0.0164 pyrazolo[3,4-b]pyridine-5-carboxamide N-{[4-(dimethyl-1,3-thiazole-5-sulfonyl)phenyl]methyl}furo[2,3- 0.0083 0.0103 c]pyridine-2-carboxamide N-{[4-(dimethyl-1,3-thiazole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.009 0.0037 a]pyridine-6-carboxamide N-{[4-(dimethyl-1,3-thiazole-5-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0037 0.0495 a]pyrimidine-6-carboxamide N-{[4-(dimethyl-1,3-thiazole-5-sulfonyl)phenyl]methyl}thieno[2,3- 0.0013 0.0030 c]pyridine-2-carboxamide N-{[4-(furan-2-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.0762 0.1-1 carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0037 0.0025 b]pyridine-5-carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.0109 0.0016 c]pyridine-2-carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0190 0.003 carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.0224 0.0041 carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0016 0.0032 a]pyrimidine-6-carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.0067 0.0008 carboxamide N-{[4-(naphthalene-1-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0091 0.00368 b]pyridine-5-carboxamide N-{[4-(naphthalene-1-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0049 0.0031 carboxamide N-{[4-(naphthalene-1-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0029 0.0036 a]pyrimidine-6-carboxamide N-{[4-(phenoxathiine-4-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.0148 0.0204 b]pyridine-5-carboxamide N-{[4-(phenoxathiine-4-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0056 0.0131 carboxamide N-{[4-(phenoxathiine-4-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine- 0.00215 0.00218 6-carboxamide N-{[4-(phenoxathiine-4-sulfonyl)phenyl]methyl}imidazo[1,2- 0.0021 0.0042 a]pyrimidine-6-carboxamide N-{[4-(pyridine-2-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0551 0.0870 carboxamide N-{[4-(pyridine-3-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0090 0.0664 carboxamide N-{[4-(pyridine-3-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6- 0.0059 0.1-1 carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine- 0.0052 0.0044 5-carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine- 0.0163 0.0029 2-carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0042 0.0032 carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.014 0.001 carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6- 0.0025 0.0036 carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.0044 0.0009 carboxamide N-{[4-(quinoline-6-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine- 0.0101 0.0041 5-carboxamide N-{[4-(quinoline-6-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0073 0.005 carboxamide N-{[4-(quinoline-6-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.00516 0.00083 carboxamide N-{[4-(quinoline-6-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6- 0.0033 0.0056 carboxamide N-{[4-(quinoline-8-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine- 0.0455 0.0236 5-carboxamide N-{[4-(quinoline-8-sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- 0.0076 0.0060 carboxamide N-{[4-(quinoline-8-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.0098 0.0055 carboxamide N-{[4-(quinoline-8-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyrimidine-6- 0.0030 0.0277 carboxamide N-({4-[(2,4-dimethoxyphenyl)sulfamoyl]phenyl}methyl)-1H- 0.0058 0.0069 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(2-hydroxyethyl)phenyl]sulfamoyl}phenyl)methyl]-1H- 0.0188 0.0199 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-fluoro-2-methoxyphenyl)sulfamoyl]phenyl}methyl)quinoline- 0.0660   1-10 6-carboxamide N-({4-[(2,3,6-trimethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.012 0.0055 c]pyridine-2-carboxamide N-({4-[(2,3-dimethoxy-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.010 0.002 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2,3-dimethoxy-5- 0.006 0.0027 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2,3-dimethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.009 0.0034 c]pyridine-2-carboxamide N-({4-[(2,3-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.014 0.007 c]pyridine-2-carboxamide N-({4-[(2,3-dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.011 0.0044 c]pyridine-2-carboxamide N-({4-[(2,4,5-trimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.008 0.0081 c]pyridine-2-carboxamide N-({4-[(2,4,6-trimethylbenzene)sulfonyl]phenyl}methyl)-1H- 0.076 0.046 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2,4-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.027 0.007 c]pyridine-2-carboxamide N-({4-[(2,4-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.021 0.012 c]pyridine-2-carboxamide N-({4-[(2,4-dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.012 0.0222 c]pyridine-2-carboxamide N-({4-[(2,5-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.017 0.006 c]pyridine-2-carboxamide N-({4-[(2,5-dimethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.004 0.0023 c]pyridine-2-carboxamide N-({4-[(2,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.011 0.014 c]pyridine-2-carboxamide N-({4-[(2,5-dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.011 0.0086 c]pyridine-2-carboxamide N-({4-[(2,6-dimethoxy-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.016 0.010 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2,6-dimethoxy-4- 0.007 0.0030 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.006 0.004 c]pyridine-2-carboxamide N-({4-[(2-acetylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.001 0.0010 2-carboxamide N-({4-[(2-chloro-6-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.013 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.006 0.117 c]pyridine-2-carboxamide N-({4-[(2-ethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.011 0.002 c]pyridine-2-carboxamide N-({4-[(2-ethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.002 0.0008 c]pyridine-2-carboxamide N-({4-[(2-ethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.005 0.003 c]pyridine-2-carboxamide N-({4-[(2-ethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.005 0.0029 2-carboxamide N-({4-[(2-fluoro-3-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.010 0.007 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.011 0.021 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.008 0.0207 c]pyridine-2-carboxamide N-({4-[(2-fluoro-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.025 0.024 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-methanesulfonamidobenzene)sulfonyl]phenyl}methyl)-1H- 0.284 >1 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-methoxy-5-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.012 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-methoxy-5- 0.006 0.0025 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(2-methoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.009 0.007 c]pyridine-2-carboxamide N-({4-[(2-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.007 0.0053 c]pyridine-2-carboxamide N-({4-[(2-methylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.014 0.013 c]pyridine-2-carboxamide N-({4-[(2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.010 0.0222 c]pyridine-2-carboxamide N-({4-[(2-phenoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.011 0.007 c]pyridine-2-carboxamide N-({4-[(2-phenoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.011 0.0697 c]pyridine-2-carboxamide N-({4-[(2-phenylethane)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.011 0.022 c]pyridine-2-carboxamide N-({4-[(3,4-difluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.013 0.014 c]pyridine-2-carboxamide N-({4-[(3,4-difluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.009 0.0081 c]pyridine-2-carboxamide N-({4-[(3,4-dimethoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.014 0.003 c]pyridine-2-carboxamide N-({4-[(3,4-dimethoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.003 0.0009 c]pyridine-2-carboxamide N-({4-[(3,4-dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.006 0.0023 c]pyridine-2-carboxamide N-({4-[(3,5-dichlorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.006 0.0007 c]pyridine-2-carboxamide N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.011 0.007 c]pyridine-2-carboxamide N-({4-[(3,5-difluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.004 0.0027 c]pyridine-2-carboxamide N-({4-[(3,5-dimethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.009 0.002 c]pyridine-2-carboxamide N-({4-[(3,5-dimethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.005 0.0018 c]pyridine-2-carboxamide N-({4-[(3-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.012 0.006 c]pyridine-2-carboxamide N-({4-[(3-acetylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.004 0.0026 2-carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.005 0.003 c]pyridine-2-carboxamide N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.005 0.003 2-carboxamide N-({4-[(3-ethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.006 0.0027 2-carboxamide N-({4-[(3-fluoro-4-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.005 0.004 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.005 0.0025 c]pyridine-2-carboxamide N-({4-[(3-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.008 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(3-fluoro-4-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.003 0.0028 c]pyridine-2-carboxamide N-({4-[(3-fluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.009 0.01 c]pyridine-2-carboxamide N-({4-[(3-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.003 0.0033 2-carboxamide N-({4-[(3-methoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.007 0.004 c]pyridine-2-carboxamide N-({4-[(3-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.005 0.0026 c]pyridine-2-carboxamide N-({4-[(3-methylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.009 0.004 c]pyridine-2-carboxamide N-({4-[(3-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.004 0.0023 c]pyridine-2-carboxamide N-({4-[(4,5-difluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.014 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4,5-difluoro-2- 0.005 0.0029 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.007 0.003 c]pyridine-2-carboxamide N-({4-[(4-acetylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.004 0.0025 2-carboxamide N-({4-[(4-chloro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.022 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-2- 0.010 0.0038 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4-chloro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.027 0.025 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)-1H- 0.008 0.013 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-3-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.003 0.0071 c]pyridine-2-carboxamide N-({4-[(4-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.009 0.025 c]pyridine-2-carboxamide N-({4-[(4-ethylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.008 0.012 c]pyridine-2-carboxamide N-({4-[(4-ethylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.006 0.0078 2-carboxamide N-({4-[(4-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.031 0.007 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.009 0.0065 c]pyridine-2-carboxamide N-({4-[(4-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.019 0.027 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.009 0.007 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-3-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.007 0.0029 c]pyridine-2-carboxamide N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.038 0.008 c]pyridine-2-carboxamide N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2- 0.023 0.011 a]pyridine-6-carboxamide N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine- 0.003 0.010 2-carboxamide N-({4-[(4-methanesulfonylbenzene)sulfonyl]phenyl}methyl)-1H- 0.024 0.012 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-methoxy-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.024 0.024 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-methoxy-3-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.01 0.002 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-methoxy-3- 0.003 0.0024 methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(4-methoxybenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.011 0.009 c]pyridine-2-carboxamide N-({4-[(4-methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.005 0.0027 c]pyridine-2-carboxamide N-({4-[(4-methylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.006 0.009 c]pyridine-2-carboxamide N-({4-[(4-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.005 0.0050 c]pyridine-2-carboxamide N-({4-[(5-acetyl-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.02 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-chloro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.006 0.002 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-chloro-2- 0.004 0.0013 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-({4-[(5-fluoro-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.005 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)-1H- 0.011 0.007 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-fluoro-2-methylbenzene)sulfonyl]phenyl}methyl)thieno[2,3- 0.003 0.0094 c]pyridine-2-carboxamide N-({4-[(5-tert-butyl-2-methoxybenzene)sulfonyl]phenyl}methyl)-1H- 0.647 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-tert-butyl-2- 0.015 0.0046 methoxybenzene)sulfonyl]phenyl}methyl)thieno[2,3-c]pyridine-2- carboxamide N-(4-(2-(trifluoromethoxy)phenylsulfonyl)benzyl)imidazo[1,2- 0.008 a]pyridine-6-carboxamide N-(4-(phenylsulfonyl)benzyl)-1H-imidazo[4,5-b]pyridine-6-carboxamide 5.780 >10 N-(4-(phenylsulfonyl)benzyl)benzo[d]thiazole-5-carboxamide 0.047 3.872 N-[(4-{[2-(benzyloxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- 0.018 0.033 c]pyridine-2-carboxamide N-[(4-{[2-(dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.951 0.484 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(methylsulfamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.076 0.202 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(morpholin-4-ylmethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.034 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(morpholin-4- 0.013 0.0036 ylmethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[2-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.016 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2- 0.004 0.0028 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.022 0.025 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.013 0.0260 c]pyridine-2-carboxamide N-[(4-{[2-fluoro-4-(1H-pyrazol-1- 0.006 0.0080 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- 0.016 0.002 yl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2-methoxy-4-(1H-pyrazol-1- 0.005 0.0026 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[2-methoxy-4- 0.022 0.005 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[2-methoxy-4- 0.009 0.0075 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]- 0.061 0.012 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5-(propan-2- 0.009 0.0062 yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2- carboxamide N-[(4-{[2-methoxy-6-(propan-2- 0.036 0.022 yloxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2- carboxamide N-[(4-{[2-methyl-4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.004 0.004 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]-1H- 0.006 0.004 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.009 0.0026 c]pyridine-2-carboxamide N-[(4-{[3-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H- 0.005 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3- 0.002 0.0024 (trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[(4-{[3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.009 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.003 0.0010 c]pyridine-2-carboxamide N-[(4-{[3-fluoro-4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]- 0.011 0.004 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(dimethylcarbamoyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.027 0.014 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-(propan-2-yl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- 0.006 0.0071 c]pyridine-2-carboxamide N-[(4-{[4-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]-1H- 0.024 0.026 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-chloro-3-(trifluoromethyl)benzene]sulfonyl}phenyl)methyl]- 0.008 0.005 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[4-chloro-3- 0.010 0.0034 (trifluoromethyl)benzene]sulfonyl}phenyl)methyl]thieno[2,3- c]pyridine-2-carboxamide N-[4-(benzenesulfonyl)phenyl]pyridine-3-carboxamide 12.038 >30 N-{[3-(benzenesulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine-2- >30 >30 carboxamide N-{[4-(1H-indole-7-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.003 0.0027 carboxamide N-{[4-(1-methyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.048 0.123 c]pyridine-2-carboxamide N-{[4-(2,3-dihydro-1,4-benzodioxine-6- 0.004 0.0027 sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-5-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.008 0.007 c]pyridine-2-carboxamide N-{[4-(2H-1,3-benzodioxole-5-sulfonyl)phenyl]methyl}thieno[2,3- 0.003 0.0025 c]pyridine-2-carboxamide N-{[4-(5-methylthiophene-2-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.007 0.013 c]pyridine-2-carboxamide N-{[4-(5-methylthiophene-2-sulfonyl)phenyl]methyl}thieno[2,3- 0.005 0.0077 c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-[1,2,3,4]tetrazolo[1,5- 0.447 >30 a]pyridine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-[1,2,4]triazolo[4,3-a]pyridine- 0.301 >10 6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1,5-naphthyridine-2- 0.875 >10 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-imidazo[4,5-c]pyridine-2- 7.062 5.37 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-3- 1.271 >10 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-pyrazolo[3,4-b]pyridine-5- 0.070 0.051 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-pyrrolo[2,3-b]pyridine-5- 1.906 >30 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-pyrrolo[2,3-c]pyridine-3- >10 >10 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1-methyl-1H-pyrazolo[3,4- 1.725 >30 b]pyridine-5-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1-methyl-1H-pyrrolo[3,2- >10 >30 c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-3-(pyridin-2-yl)-1H-pyrazole-5- 7.429 23.371 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-3-(pyridin-3-yl)-1,2-oxazole-5- 0.033 >30 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-3-(pyridin-4-yl)-1H-pyrazole-5- 3.176 21.554 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-3-bromo-1H-pyrrolo[3,2- 0.306 7.390 c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-5-(pyridin-3-yl)-1,2,4- 0.312 >30 oxadiazole-3-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-5-(pyridin-3-yl)-1H-pyrazole-3- 0.023 11.825 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyrazine-2- 1.491 >30 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.021 0.011 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}isoquinoline-6-carboxamide 16.082 21.303 N-{[4-(benzenesulfonyl)phenyl]methyl}isoquinoline-7-carboxamide 0.219 24.000 N-{[4-(benzenesulfonyl)phenyl]methyl}quinazoline-6-carboxamide 16.082 21.303 N-{[4-(benzenesulfonyl)phenyl]methyl}thieno[2,3-b]pyrazine-6- 0.052 >30 carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.011 0.012 carboxamide N-{[4-(isoquinoline-4-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.003 0.0007 carboxamide N-{[4-(naphthalene-1-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.002 0.0005 carboxamide N-{[4-(phenoxathiine-4-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2- 0.005 0.0009 c]pyridine-2-carboxamide N-{[4-(phenoxathiine-4-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine- 0.004 0.0017 2-carboxamide N-{[4-(phenylmethane)sulfonylphenyl]methyl}-1H-pyrrolo[3,2- 0.029 0.3015 c]pyridine-2-carboxamide N-{[4-(pyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine-2- 0.021 0.048 carboxamide N-{[4-(quinoline-3-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.003 0.0008 carboxamide N-{[4-(quinoline-6-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.003 0.0009 carboxamide N-{[4-(quinoline-8-sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- 0.006 0.0025 carboxamide N-{2-[4-(benzenesulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2- 0.410 9.1 carboxamide N-({4-[(1H-indazol-6-yl)sulfamoyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.135 5.44 c]pyridine-2-carboxamide N-({4-[(1-oxo-1H-isochromen-5-yl)sulfamoyl]phenyl}methyl)-1H- 0.008 2.27 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfamoyl]phenyl}methyl)-1H- >10 >10 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-acetylphenyl)sulfamoyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.005 0.005 c]pyridine-2-carboxamide N-({4-[(2-methoxy-6-methylphenyl)sulfamoyl]phenyl}methyl)-1H- 0.006 12.4 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(2-methoxyphenyl)sulfamoyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.089 2.150 c]pyridine-2-carboxamide N-({4-[(2-phenoxyphenyl)sulfamoyl]phenyl}methyl)-1H-pyrrolo[3,2- 4.019 12.000 c]pyridine-2-carboxamide N-({4-[(2-propoxyphenyl)sulfamoyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.052 0.100 c]pyridine-2-carboxamide N-({4-[(3-methoxy-2-methylphenyl)sulfamoyl]phenyl}methyl)-1H- 0.030 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-chloro-2-methoxy-5-methylphenyl)sulfamoyl]phenyl}methyl)- 7.835 18.322 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-ethoxy-2-fluorophenyl)sulfamoyl]phenyl}methyl)-1H- 0.154 1.600 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluoro-2-methoxyphenyl)sulfamoyl]phenyl}methyl)-1H- 3.138 >30 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-methoxy-2-methylphenyl)sulfamoyl]phenyl}methyl)-1H- 1.451 >30 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5,6,7,8-tetrahydronaphthalen-1-yl)sulfamoyl]phenyl}methyl)- >30 >30 1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-chloro-2-methoxyphenyl)sulfamoyl]phenyl}methyl)-1H- 0.197 17.984 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-fluoro-2-methoxyphenyl)sulfamoyl]phenyl}methyl)-1H- 0.232 >30 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(5-methoxy-2-methylphenyl)sulfamoyl]phenyl}methyl)-1H- 0.051 13.018 pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(quinolin-8-yl)sulfamoyl]phenyl}methyl)-1H-pyrrolo[3,2- 0.075 1.478 c]pyridine-2-carboxamide N-[(4-{[2-(2-hydroxyethoxy)phenyl]sulfamoyl}phenyl)methyl]-1H- 19.611 23.854 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(hydroxymethyl)phenyl]sulfamoyl}phenyl)methyl]-1H- 0.030 0.006 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(morpholin-4-yl)phenyl]sulfamoyl}phenyl)methyl]-1H- 0.019 0.017 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(piperidin-1-yl)phenyl]sulfamoyl}phenyl)methyl]-1H- 0.072 0.008 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(propan-2-yloxy)phenyl]sulfamoyl}phenyl)methyl]-1H- 0.003 0.001 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(trifluoromethoxy)benzene]sulfonamido}phenyl)methyl]-1H- 0.003 0.001 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-(trifluoromethoxy)phenyl]sulfamoyl}phenyl)methyl]-1H- 0.006 0.001 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{[2-methoxy-5- 0.0005 0.0016 (trifluoromethyl)phenyl]sulfamoyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{[4-chloro-2- 0.002 0.002 (trifluoromethoxy)phenyl]sulfamoyl}phenyl)methyl]-1H-pyrrolo[3,2- c]pyridine-2-carboxamide N-[(4-{8-oxa-3-azabicyclo[3.2.1]octane-3-sulfonyl}phenyl)methyl]-1H- 0.008 0.003 pyrrolo[3,2-c]pyridine-2-carboxamide N-[(4-{8-oxa-3-azabicyclo[3.2.1]octane-3- 0.004 0.003 sulfonyl}phenyl)methyl]imidazo[1,2-a]pyridine-6-carboxamide N-[(4-{8-oxa-3-azabicyclo[3.2.1]octane-3- 0.015 0.003 sulfonyl}phenyl)methyl]thieno[2,3-c]pyridine-2-carboxamide N-[(4-benzamidophenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2- 0.019 0.004 carboxamide N-[(4-benzenesulfonamidophenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2- 0.011 0.005 carboxamide N-[4-(piperidine-1-sulfonyl)phenyl]-1H-pyrrolo[3,2-c]pyridine-2- 0.008 0.006 carboxamide N-[4-(piperidine-1-sulfonyl)phenyl]-2-(pyridin-3-yloxy)acetamide 0.0011 0.0066 N-[4-(piperidine-1-sulfonyl)phenyl]-3-(pyridin-3-yl)propanamide 0.003 0.007 N-{[1-(benzenesulfonyl)piperidin-4-yl]methyl}-1H-pyrrolo[3,2- 0.015 0.009 c]pyridine-2-carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-[1,2,3,4]tetrazolo[1,5- 0.003 0.009 a]pyridine-7-carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1,3-benzothiazole-6- 0.009 0.010 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1,6-naphthyridine-2- 0.012 0.010 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1H-1,3-benzodiazole-5- 0.021 0.010 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1H-imidazo[1,2- 0.0008 0.0110 b]pyrazole-5-carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1H-indazole-5- 0.018 0.016 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1H-pyrazolo[3,4- 0.017 0.033 b]pyridine-5-carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1H-pyrrolo[2,3-c]pyridine- 0.004 0.054 2-carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine- 0.023 0.200 2-carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}furo[3,2-c]pyridine-2- 0.017 0.286 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6- 0.018 1.160 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-7- >0.1 >0.5 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}pyridine-3-carboxamide 0.039 0.64 N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}thieno[2,3-b]pyridine-2- 6.146 14.000 carboxamide N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}thieno[3,2-c]pyridine-2- 0.886 10 carboxamide N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine- 0.020 0.007 2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-5,6,7,8-tetrahydro-1,6- 0.544 >2 naphthyridine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-5H,6H,7H-pyrrolo[3,4- 0.020 >2 b]pyridine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H,4H,5H,6H,7H-pyrazolo[4,3- >2 >2 c]pyridine-5-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-5H,6H,7H,8H-pyrido[4,3- >2 >2 d]pyrimidine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H,4H,5H,6H,7H-imidazo[4,5- >2 >2 c]pyridine-5-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-4H,5H,6H,7H-[1,2]oxazolo[4,3- >2 >2 c]pyridine-5-carboxamide

Assay Example 3

(527) In-Vitro Cell Proliferation Assay

(528) U251 cells were seeded in 96-well plates at 1.25×103 cells/well in 180 μL of culture medium (10% FBS, 1% Pen/Strep Amphotecricin B, RPMI-5 1640) with and without the addition of either nicotinamide mononucleotide (NMN) or nicotinamide (NAM). After overnight incubation at 37° C. and 5% C02, the compound titrations were performed in a separate dilution plate by serially diluting the compounds in DMSO to make a 1000× stock. The compounds were then further diluted to 10× final concentration in culture media, whereupon 20 μL of each dilution was added to the plated cells with controls (e.g. DMSO and blank) to make a final volume of 5 200 μL. The final DMSO concentration in each well was 0.1%. The plates were then incubated for 72 hours at 37° C. in a 5% C02 incubator. The number of viable cells was then assessed using sulforhodamine B (SRB) assay. Cells were fixed at 4° C. for 1 hour with the addition of 50 μL 30% trichloroacetic acid (TCA) to make a final concentration of 6% 10 TCA. The plates were washed four times with H2O and allowed to dry for at least 1 hour, whereupon 100 μL of a 4% SRB in 1% acetic acid solution was added to each well and incubated at room temperature for at least 30 minutes. The plates were then washed three times with 1% acetic acid, dried, and treated with 100 μL of 10 mM Tris-Base solution. The plates were then read in a microplate reader at an absorbance of 570 nm. 15 Background was generated on a separate plate with media only.

(529) Method for Determining % Inhibition

(530) First, the signals from the background plate are averaged, then the background was subtracted from the test plates. The compound-treated cells were then assayed for % 20 inhibition by using the following formula:
% Inh=100−100*x/y
wherein x denotes the average signal of the compound-treated cells and y denotes the average signal of the DMSO-treated cells.
25 Formula for Determining IC50 Values:
IC50=10{circumflex over ( )}(LOG 10(X)+(((50−% Inh at Cmpd Concentration1)/(XXYY)*(LOG 10(X)−LOG 10(Y))))
wherein X denotes the compound concentration 1, Y denotes the compound concentration 2, XX denotes the % inhibition at compound concentration 1 (X), and YY
30 denotes the % inhibition at compound concentration 2 (Y).
Table 4 below shows U251-values for some compounds.

(531) TABLE-US-00004 U251 Chemical name IC50 (uM) N-{[4-(benzenesulfonyl)phenyl]methyl}thieno[3,2- >2 b]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}imidazol[1,5- >2 a]pyridine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}-1H- 0.040 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[5-(benzenesulfonyl)pyridin-2-yl]methyl}-1H- 0.035 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}imidazo[1,2- >2 a]pyrazine-6-carboxamide N-{[4-(benzenesulfonyl)phenyl]methyl}furo[3,2- 0.545 b]pyridine-2-carboxamide N-{[6-(benzenesulfonyl)pyridin-3-yl]methyl}-1H- >2 pyrrolo[3,2-c]pyridine-2-carboxamide N-{[4-(piperazine-1-sulfonyl)phenyl]methyl}thieno[2,3- 0.405 c]pyridine-2-carboxamide N-{[4-(piperazine-1- 0.556 sulfonyl)phenyl]methyl}imidazol[1,2-a]pyridine-6- carboxamide N-{[4-(3-aminopyrrolidine-1- 0.31 sulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2- carboxamide hydrochloride N-{[4-(3-aminopyrrolidine-1- 1.85 sulfonyl)phenyl]methyl}furo[2,3-c]pyridine-2- carboxamide hydrochloride N-({4-[(3,5- 0.0066 difluorobenzene)sulfinyl]phenyl}methyl)imidazo[1,2- a]pyridine-6-carboxamide
Xenograft Studies:

(532) C.B-17-Igh-Ib-Prkdc.sup.scid mice (female) were injected s.c. with 5×10.sup.6 A2780 cells (NCI) in the left flank. 10-12 days later when tumors reached 100-200 mm3 in size, mice were randomized into treatment groups of 8 mice per group including vehicle control and reference standard groups. The compounds were formulated in 60:30:10 PEG-400:D5W: Ethanol and administered p.o., at the dose volume of 10 ml/kg BID for a duration of 5 or 10 days. The dose used for efficacy was selected from the MTD (Maximum Tolerated Dose) study. Mice were weighed and tumors measured using vernier calipers every alternate day. Tumor volume was calculated according to the formula (length×width.sup.2)/2. All animal work was approved by the Institutional Animal Care and Use Committee of Biological Resource Centre, Singapore.

(533) The compound N-[(4-{[2-(trifluoromethoxy)phenyl]sulfamoyl} phenyl) methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide produced tumor stasis.

(534) The following compounds produced tumor regression: N-{[4-(benzenesulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-6-carboxamide; N-{[4-(benzenesulfonyl)phenyl]methyl}thieno[2,3-c]pyridine-2-carboxamide; N-{[4-(benzenesulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N-({4-[(4-fluorobenzene)sulfonyl]phenyl}methyl)imidazo[1,2-a]pyridine-6-carboxamide; N-({4-[(4-acetylbenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N-[(4-{[2-(trifluoromethoxy)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide; N-({4-[(3-chlorobenzene)sulfonyl]phenyl}methyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide.

(535) The following compounds delayed tumor growth; N-{[4-(pyridine-3-sulfonyl)phenyl]methyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide. N-[(4-{[2-methoxy-4-(1H-pyrazol-1-yl)benzene]sulfonyl}phenyl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

(536) While the present invention has been described in conjunction with the specific embodiments set forth above, many alternatives, modifications and other variations thereof will be apparent to those of ordinary skill in the art. All such alternatives, modifications and variations are intended to fall within the spirit and scope of the present invention.