Abstract
A clot retrieval device for removing clot from a blood vessel including a plurality of ring elements comprising a plurality of struts forming one or more closed cells having one or more crown elements and attached together by connecting tethers at connection points, a plurality of openings through which clot may pass and enter the device, each opening being disposed between respective ring elements. Each ring element can be self-expandable from a collapsed configuration to an expanded configuration wherein a radial force biases the ring elements toward the expanded configuration. At least one of the crown element terminates in an apex away from a center axis of the device.
Claims
1. A clot retrieval device for removing a clot from a blood vessel, comprising: a plurality of ring elements comprising: one or more distal apices; one or more proximal apices offset from the one or more distal apices; and a plurality of struts forming one or more closed cells having one or more crown elements, wherein the plurality of ring elements are attached together by connecting tethers at connection points including at at least the one or more proximal apices; and a plurality of openings through which the clot may pass and enter the device, each opening being disposed between respective ring elements; wherein each ring element being self-expandable from a collapsed configuration to an expanded configuration wherein a radial force biases the ring elements toward the expanded configuration; and wherein at least one of the crown elements terminates in an apex away from a center axis of the device.
2. The device of claim 1, wherein adjacent struts of the plurality of struts of each of the plurality of ring elements couple to one another in the collapsed configuration and uncouple from one another in the expanded configuration.
3. The device of claim 1, wherein in the expanded configuration, a distal end of at least one end of the ring elements extends radially outwardly.
4. The device of claim 1, wherein the one or more distal apices and the one or more proximal apices are offset from each other in a sinusoidal configuration.
5. A clot retrieval device comprising: a plurality of clot engaging ring elements, the plurality of clot engaging ring elements comprising distal apices, proximal apices offset from the distal apices, and struts connected between respective distal and proximal apices of respective clot engaging ring elements, each clot engaging ring element being expandable between a retracted delivery configuration and an expanded deployed configuration, wherein the plurality of clot engaging ring elements are attached together by connecting tethers at connection points including at at least the proximal apices, and wherein to move to the expanded deployed configuration from the retracted delivery configuration, a shaft is axially translated thereby applying a radial force that biases the plurality of clot engaging ring elements to expand to the expanded deployed configuration.
6. The device of claim 5, further comprising: the shaft extending between a proximal end and a distal end, the clot engaging ring elements being connected to the distal end of the shaft.
7. The device of claim 5, wherein respective struts of respective clot engaging ring elements are connected through the connecting tethers.
8. The device of claim 5, wherein each of the clot engaging ring elements comprise a collar and an interior circumferential surface.
9. The device of claim 5, wherein each of the plurality of clot engaging ring elements is connected to at least one other of the plurality of clot engaging ring elements.
10. The device of claim 5, wherein in the expanded deployed configuration, a clot inlet opening is defined between the distal side of a first clot engaging ring element and a second adjacent clot engaging ring element.
11. The device of claim 5, wherein adjacent struts of the struts of each of the plurality of clot engaging ring elements couple to one another in the retracted delivery configuration and uncouple from one another in the expanded deployed configuration.
12. The device of claim 11, wherein connectors of the adjacent struts of the struts of each of the plurality of clot engaging ring elements include hooks.
13. The device of claim 5, wherein, in a partially deployed configuration, a distal end of at least one of the plurality of clot engaging ring elements tapers radially outwardly.
14. The device of claim 13, further including a tube, wherein the shaft is axially translatable within a lumen of the tube.
15. The device of claim 14, wherein the tube includes a proximal collar.
16. A clot retrieval device comprising: a shaft extending between a proximal end and a distal end; at least three clot engaging ring elements, the clot engaging ring elements comprising one or more distal apices, one or more proximal apices offset from the one or more distal apices, and struts connected through one or more connectors, each clot engaging ring element being expandable between a retracted delivery configuration and an expanded deployed configuration, wherein the at least three clot engaging ring elements are attached together by connecting tethers at connection points including at at least the one or more proximal apices, wherein in the retracted delivery configuration, the at least three clot engaging ring elements are configured to radially surround the shaft; and wherein to move to the expanded deployed configuration from the retracted delivery configuration, the shaft is axially translated thereby biasing the at least three clot engaging ring elements to expand to the expanded deployed configuration.
17. The device of claim 16, wherein the connecting tethers are disposed between a distal side of a first clot engaging ring element of the at least three clot engaging ring elements, and a proximal side of a second adjacent clot engaging ring element of the at least three clot engaging ring elements.
18. The device of claim 16, wherein in the expanded deployed configuration, a clot inlet opening is defined between each adjacent clot engaging ring element.
19. The device of claim 16, wherein the clot engaging ring elements comprise one or more crown elements that terminate in an apex away from a center axis of the device, wherein in the expanded deployed configuration, a clot inlet opening for receiving a clot is defined between distal and proximal sides of each adjacent clot engaging ring element.
20. The device of claim 16, wherein adjacent struts of the struts of each of the at least three clot engaging ring elements couple to one another in the retracted delivery configuration and uncouple from one another in the expanded deployed configuration.
21. The device of claim 16, further including a microcatheter, wherein the shaft is axially translatable within a lumen of the microcatheter.
22. The device of claim 16, wherein one or more tethers are connected to the shaft.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) The invention will be more clearly understood from the following description of some embodiments thereof, given by way of example with reference to the accompanying drawings, in which:
(2) FIG. 1a is a diagram illustrating a typical occlusive clot in a cerebral artery;
(3) FIG. 1b is an enlarged view of a detail of FIG. 1a;
(4) FIGS. 2a-2h are diagrams illustrating the insertion of a guidewire and the deployment of a clot retrieval device of the invention;
(5) FIGS. 3a-3e illustrate a clot retrieval device according to one embodiment of the invention;
(6) FIGS. 4a-4d illustrate steps involved in using the device of FIGS. 3a-3d;
(7) FIGS. 5a-5e illustrate another clot retrieval device of the invention;
(8) FIGS. 6a-6f illustrate a further clot retrieval device of the invention;
(9) FIGS. 7a-7e illustrate another clot retrieval device of the invention;
(10) FIGS. 8a-8d illustrate a further clot retrieval device of the invention;
(11) FIGS. 9a-9d illustrate another clot retrieval device of the invention;
(12) FIGS. 10a-10d illustrate a further clot retrieval device of the invention;
(13) FIGS. 11a-11h illustrate another clot retrieval device of the invention;
(14) FIGS. 12a-12c illustrate a further clot retrieval device of the invention;
(15) FIGS. 13a-13f illustrate another clot retrieval device of the invention;
(16) FIGS. 14a-14c illustrate a further clot retrieval device of the invention;
(17) FIGS. 15a-15c illustrate a method for using a clot retrieval device of the invention;
(18) FIGS. 16a-16d illustrate another method for using a clot retrieval device of the invention;
(19) FIGS. 17a-17d illustrate a further clot retrieval device of the invention;
(20) FIGS. 18a-18d illustrate another clot retrieval device of the invention;
(21) FIGS. 19a-19d illustrate a further clot retrieval device of the invention;
(22) FIGS. 20a-20b illustrate another clot retrieval device of the invention;
(23) FIGS. 21a-21f illustrate a further clot retrieval device of the invention;
(24) FIGS. 22a-22d illustrate a method for using a clot retrieval device of the invention;
(25) FIGS. 23a-23c illustrate a mechanism used in a clot retrieval device of the invention;
(26) FIGS. 24a-24c illustrate a further clot retrieval device of the invention;
(27) FIGS. 25a-25k illustrate another clot retrieval device of the invention;
(28) FIGS. 26a-26d illustrate a further clot retrieval device of the invention;
(29) FIGS. 27a-27b illustrate another clot retrieval device of the invention;
(30) FIGS. 28a-28b illustrate a further clot retrieval device of the invention;
(31) FIGS. 29a-29h illustrate a method for using a clot retrieval device of the invention;
(32) FIGS. 30a-30e illustrate another clot retrieval device of the invention;
(33) FIGS. 31a-31e illustrate a further clot retrieval device of the invention;
(34) FIGS. 32a-32d illustrate another clot retrieval device of the invention;
(35) FIGS. 33a-33g illustrate a further clot retrieval device of the invention;
(36) FIGS. 34a-34j illustrate another clot retrieval device of the invention;
(37) FIGS. 35a-35b illustrate a further clot retrieval device of the invention;
(38) FIGS. 36a-36d illustrate another clot retrieval device of the invention;
(39) FIGS. 37a-37i illustrate a further clot retrieval device of the invention;
(40) FIGS. 38a-38d illustrate another clot retrieval device of the invention;
(41) FIGS. 39a-39d illustrate a further clot retrieval device of the invention;
(42) FIGS. 40a-40e illustrate a method for using a clot retrieval device of the invention;
(43) FIGS. 41a-41d illustrate another method for using a clot retrieval device of the invention;
(44) FIGS. 42a-42g illustrate a further clot retrieval device of the invention;
(45) FIGS. 43a-43h illustrate another clot retrieval device of the invention;
(46) FIGS. 44a-44b illustrate a further clot retrieval device of the invention;
(47) FIG. 45 illustrates another clot retrieval device of the invention;
(48) FIG. 46 illustrates a further clot retrieval device of the invention;
(49) FIG. 47 illustrates another clot retrieval device of the invention;
(50) FIGS. 48a-48f illustrate a further clot retrieval device of the invention;
(51) FIGS. 49a-49f illustrate another clot retrieval device of the invention;
(52) FIGS. 50a-50g illustrate a further clot retrieval device of the invention;
(53) FIGS. 51a-51f illustrate another clot retrieval device of the invention;
(54) FIGS. 52a-52d illustrate a further clot retrieval device of the invention;
(55) FIGS. 53a-53f illustrate a method for using a clot retrieval device of the invention;
(56) FIGS. 54a-54h illustrate another method for using a clot retrieval device of the invention;
(57) FIG. 55 illustrates another clot retrieval device of the invention;
(58) FIG. 56 illustrates a further clot retrieval device of the invention;
(59) FIG. 57 illustrates another clot retrieval device of the invention;
(60) FIG. 58 illustrates a further clot retrieval device of the invention;
(61) FIG. 59 illustrates a further clot retrieval device of the invention;
(62) FIG. 60 illustrates another clot retrieval device of the invention;
(63) FIGS. 61a-61c illustrate a further clot retrieval device of the invention;
(64) FIGS. 62a-62b illustrate another clot retrieval device of the invention;
(65) FIGS. 63a-63b illustrate a further clot retrieval device of the invention;
(66) FIGS. 64a-64b illustrate another clot retrieval device of the invention;
(67) FIGS. 65a-65d illustrate a further clot retrieval device of the invention;
(68) FIGS. 66a-66c illustrate another clot retrieval device of the invention;
(69) FIGS. 67a-67b illustrate a further clot retrieval device of the invention;
(70) FIGS. 68a-68b illustrate another clot retrieval device of the invention;
(71) FIGS. 69a-69b illustrate a further clot retrieval device of the invention; and
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
(72) Specific embodiments of the present invention are now described in detail with reference to the figures, wherein similar reference numbers indicate identical or functionality similar elements. The terms “distal” or “proximal” are used in the following description with respect to a position or direction relative to the treating physician. “Distal” or “distally” are a position distant from or in a direction away from the physician. “Proximal” or “proximally” or “proximate” are a position near or in a direction toward the physician.
(73) The following detailed description is merely exemplary in nature and is not intended to limit the invention or the application and uses of the invention. Although the description of the invention is in the context of treatment of blood arteries such as the carotid and lung arteries, the invention may also be used in any other vessels where it is deemed useful.
(74) As shown generally in FIGS. 1a-1b and 2a-2h, an obstructive clot 2 is occluding a cerebral artery 1 and a guidewire 3 is inserted into the artery 1 using conventionally known techniques. The guidewire 3 is advanced across the clot 2 and then a microcatheter 4 is advanced over the guidewire 3 to a location distal to the clot 2. The mechanical clot retrieval device 10 of the present invention is advanced through the microcatheter 4 and across the clot 2. The retrieval device 10 has an elongate member 11 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 12 configured at the distal end of the elongate member. The ring elements 12 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 12 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 11. When the retrieval device 10 is advanced through the microcatheter 4, the ring elements are in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 11. Each ring element 12 comprising a plurality of struts 13 is made of self expanding material such as nitinol and is interconnected by ring connecting tethers 14. The microcatheter 4 is retracted after the retrieval device 10 is positioned within or distal of the clot 2 to allow ring elements 12 to deploy and expand. When the ring elements 12 deploy and expand, the struts 13 engage or capture the clot 2 in the ring elements 12 and the retrieval device 10 is retracted proximally out of the artery 1.
(75) FIGS. 3a-3d illustrates one of the preferred embodiments of a mechanical clot retrieval device 20 of the present invention. The retrieval device 20 has an elongate member 21 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 22 configured at the distal end of the elongate member 21. The ring elements 22 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 22 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 21. Each ring element 22 comprising a plurality of struts 23 is made of shape memory material Nitinol and is interconnected by ring connecting tethers 24. Each strut 23 has a crown element 27 with an engagement member 29 and a fixed tab 30. The crown element 27 holds the neighboring crown element 27 in a snap-fit mechanism 28 to restrain the ring elements 22 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 21. Two pull tethers 25 which have distal ends that are attached to most proximal ring element 22, and proximal ends that extend exterior of the artery for maneuvering and control by the physician, are present. The snap-fit mechanism 28 restrains the retrieval device 20 in the collapsed configuration when advancing through a microcatheter 4.
(76) FIGS. 4a-4d shows a method of using the retrieval device 20 in accordance with the preferred embodiment as shown in FIGS. 3a-3d. A guidewire (not shown) is inserted in the cerebral artery 1 and is advanced distally across an obstructive clot 2. A microcatheter 4 is advanced over the guidewire to a location proximal to the clot and then the retrieval device 20 of the present invention is advanced through the microcatheter 4 to the clot in the collapsed configuration. The retrieval device 20 has an elongate member 21 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 22 configured at the distal end of an elongate member 21. The ring elements 22 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 22 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 21. When the retrieval device 20 is advanced through the microcatheter 4, the ring elements are in collapsed configuration substantially parallel to the longitudinal axis of the elongate member 21. Each ring element 22 comprises a plurality of struts 23 and is made of shape memory material nitinol and is interconnected by ring connecting tethers 24. The microcatheter 4 is retracted when the retrieval device 20 is positioned within or distal of the clot 2 to allow ring elements 22 to reach the expanded configuration. The pull tethers 25 attached to the retrieval device 20 allow the physician to manually disengage the snap-fit mechanism 28. The ring elements 22 engage or capture the clot 2 from the distal surface of the clot 2 and retract the clot 2 proximally towards the microcatheter 4. The microcatheter 4 is re-advanced to reduce the expanded configuration of the proximal end of the device 20 in order to retrieve it more easily from the artery 1.
(77) FIGS. 5a-5d shows a mechanical clot retrieval device 40 of the present invention which is a slight variant of the embodiment of the retrieval device as shown in FIGS. 3a-3d. The retrieval device 40 has an elongate member 41 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 42 configured at the distal end of the elongate member 41, and a proximal collar 51. The ring elements 42 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 42 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 41. Each ring element 42 comprising a plurality of struts 43 and is made of shape memory material Nitinol and is interconnected by ring connecting tethers 44. Also present are a pair of pull tethers 45, having distal ends which are attached to the most proximal ring element 42 and the proximal ends are attached to the elongate member 41. Each strut 43 has a crown element 47 with an engagement member 49 and an engagement hook 50. Each crown element 47 holds the neighboring crown element 47 in a snap-fit mechanism 48 which restrains the ring elements 42 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 41. The snap-fit configuration 48 restrains the retrieval device 40 in the collapsed configuration when advancing through the microcatheter 4.
(78) Another embodiment of the mechanical clot retrieval device of the present invention, which is similar to the one shown in FIGS. 3a-3d, is illustrated in FIGS. 6a-6f The retrieval device 60 has an elongate member 61 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 62 configured at the distal end of the elongate member 61. The ring elements 62 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 62 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 61. Each ring element 62, comprising a plurality of struts 63, is made of shape memory material Nitinol and is interconnected by ring connecting tethers 64. Each strut 63 has a crown element 67 with an engagement member 68. Each engagement member 68 holds the neighboring crown element 67 in a snap-fit mechanism which restrains the ring elements 62 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 61. A pair of pull tethers 65 are attached, having distal ends which are attached to each connector (not labeled) of the crown element 67, and proximal ends which extend exterior of the artery for manipulation and control by the physician. The snap-fit mechanism restrains the retrieval device 60 in the collapsed configuration as it is advancing through the microcatheter 4. The pull tethers 65 may be used to manually disengage the snap-fit mechanism and allow the retrieval device 60 reach the expanded configuration.
(79) Another embodiment of the mechanical clot retrieval device of the present invention, which is largely similar to the one shown in FIGS. 3a-3d, is illustrated in FIGS. 7a-7f The retrieval device 80 has an elongate member 81 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 82 configured at the distal end of the elongate member 81. The ring elements 82 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 82 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 81. Each ring element 82, comprising a plurality of struts 83, is made of shape memory material Nitinol and is interconnected by ring connecting tethers 84. Each strut 83 has a crown element 87 with an engagement member 89 and an engagement tab 88. Each crown element 87 holds the neighboring crown element 87 in a snap-fit mechanism which restrains the ring elements 82 in the collapsed configuration substantially parallel to the longitudinal axis of the elongate member 81. A pair of pull tethers 85 is attached, having distal ends which are attached to each engagement tab 88 of the crown element 87, and proximal ends which extend exterior of the artery for manipulation and control by the physician. The snap-fit mechanism restrains the retrieval device 80 in the collapsed configuration as it is advancing through the microcatheter 4. The pull tethers 85 may be used to manually disengage the snap-fit mechanism and allow the retrieval device 80 to reach the expanded configuration.
(80) Another preferred embodiment of the mechanical clot retrieval device 100 of the present invention is illustrated in FIGS. 8a-8d. The retrieval device 100 includes an elongate member 101 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 102 arranged at the distal end of the elongate member 101, a fixed proximal collar 111 and a distal moveable collar 110. The ring elements 102 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 102 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 101. Each ring element 102 comprising a plurality of struts 103 is made of shape memory material nitinol and is interconnected by ring connecting tethers 104. Each strut 103 has a hook lock 107 with first lock 108 and second lock 109. Each hook lock 107 holds the neighboring hook lock 107 in a snap-fit mechanism to restrain the ring elements 102 in the collapsed configuration substantially parallel to the axis of the elongate member 101. There are pair of pull tethers 105 attached, having distal ends which are attached to the distal collar 110, and proximal ends that extend exterior of the artery for maneuvering and control by the physician. The snap-fit mechanism restrains the retrieval device in the collapsed configuration when advancing through the microcatheter 4. The distal collar 110 is pulled proximally by the pull tether 105 to manually disengage and allow ring elements 102 reach an expanded configuration.
(81) FIGS. 9a-9d shows a mechanical clot retrieval device 120 of the present invention, which is a slight variant of the embodiment of the retrieval device 100 as shown in FIGS. 8a-8d; the only difference is use of a balloon 125 in place of the distal moveable collar 110. The retrieval device 120 has an elongate member having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 122 configured at the distal end of the elongate member 121, a proximal collar 126 and a balloon 125. The ring elements 122 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 122 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 121. Each ring element 122 comprises a plurality of struts 123 and is made of shape memory material nitinol and is interconnected by ring connecting tethers 124. Each strut 123 has a hook lock 127 with a first lock 128 and a second lock 109. Each hook lock 127 holds the neighboring hook lock 127 in a snap-fit mechanism to restrain the ring elements 122 in the collapsed configuration. The balloon 125 is in a collapsed state when the device 20 is advanced through the microcatheter 4. The balloon 125 is inflated to disengage and allow ring elements 122 to reach the expanded configuration.
(82) Another embodiment of a mechanical clot retrieval device 140 of the present invention is largely similar to the one shown in FIGS. 8a-8d, and is shown in FIGS. 10a-10d; with the main difference being the use of a ball element 145 in place of the distal movable collar 110. The retrieval device 140 has an elongate member 141 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 142 configured at the distal end of the elongate member 141, a proximal collar 150 attached to a push tube 146, and a ball element 145. The ring elements 142 are self-expandable from a collapsed configuration to an expanded configuration and feature a radial force that biases the ring elements 142 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 141. Each ring element 142, comprising a plurality of struts 143, is made of shape memory material nitinol and is interconnected by ring connecting tethers 144. Each strut 143 has a hook lock 147 with a first lock 148 and a second lock 149. Each hook lock 147 holds the neighboring hook lock 147 in a snap-fit mechanism to restrain the device 140 in the collapsed configuration. The ball element 145 is manually pulled proximally through the device 140 to force apart the ring elements 142 which subsequently form the expanded configuration.
(83) FIGS. 11a-11h shows another preferred embodiment of a mechanical clot retrieval device of the present invention. The retrieval device 160 includes an elongate member 161 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 162 attached to the elongate member 161 by connecting tethers 164 at connection points 165. The ring elements 162 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 162 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 161. Each ring element 162, comprising a plurality of struts 163, is made of shape memory material nitinol. Each strut 163 features a crown element 169, which includes a proximal ring crown 167 and a distal ring crown 166. The connecting tether 164 connects the proximal ring crown 167 with the elongate member 161. The crown element 169 engages with the elongate member 161 in a snap-fit mechanism to restrain the ring elements 162 in the collapsed configuration. The snap-fit mechanism 168 restrains the retrieval device 160 in the collapsed configuration as it advances through a microcatheter 4. The microcatheter 4 is retracted proximally to disengage and allow the ring elements 162 to reach the expanded configuration. The elongate member 161 is manually retracted to disengage the snap-fit mechanism.
(84) Another embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 12a-12c. A guidewire is inserted inside a cerebral artery 501 using conventional techniques. The guidewire is advanced across an obstructive clot 502 and then an intravascular microcatheter 504 is advanced over the guidewire to a location proximal to the clot 502. The retrieval device 520 has an elongate member having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 522 configured at the distal end 526 of the elongate member 521. The ring elements 522 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 522 towards the expanded configuration. Each ring element 522, comprising a plurality of struts 523, is made of shape memory material nitinol and is interconnected by ring connecting tethers 524. Each strut 523 has a crown element 527 attached to the elongate member 521 by a bonding agent 528 to restrain the ring elements 522 in the collapsed configuration. The radial force is absorbed by the bonding agent 528 to restrain the retrieval device 520 in the collapsed configuration when the device is advancing through the microcatheter 504. The bonding agent 528 is dissolved in vivo to disengage and allow the ring elements 522 to reach the expanded configuration. The device has a pair of pull tethers 525, having distal ends which are attached to most proximal ring element 522 and proximal ends that extend out of the artery for maneuvering and control by the physician.
(85) FIGS. 13a-13f shows a slight variant embodiment of a mechanical clot retrieval device of the present invention, largely similar to the one shown in FIGS. 12a-12c. The difference between the two is the use of a soluble covering 548 in place of the bonding agent 528. The retrieval device 540 has an elongate member, having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 542 configured at the distal end 546 of the elongate member 541. The ring elements 542 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 542 towards the expanded configuration. Each ring element 542, comprising a plurality of struts 543, is made of shape memory material nitinol and is interconnected by ring connecting tethers 544. Each strut 543 has a crown element 547 attached to the elongate member 541 by a re-absorbable covering 548 to restrain the ring elements 542 in the collapsed configuration. The radial force is absorbed by the re-absorbable covering 548 to restrain the retrieval device 540 in the collapsed configuration when it is advancing through the microcatheter (not shown). The re-absorbable covering 548 is dissolved in vivo to disengage and allow the ring elements 542 to reach the expanded configuration. The device features a pair of pull tethers 545, having distal ends which are attached to the most proximal ring element 542 and proximal ends that extend out of the artery for maneuvering and control by the physician.
(86) Another preferred embodiment of a mechanical clot retrieval device of the present invention is shown in FIGS. 14a-14c. The retrieval device 1020 includes an elongate member 1021 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of radial pins 1028, and a plurality of ring elements 1022 configured at the distal end 1026 of the elongate member 1021. The ring elements 1022 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases ring elements 1022 towards the expanded configuration. Each ring element 1022, comprising a plurality of struts, is made of shape memory material nitinol and each strut 1023 contains a crown element 1027 with an eyelet 1024. The distal eyelet 1024 engages with the radial pin 1028 by an engagement element 1029 to fasten the ring elements to the elongate member, whereas proximal eyelets 1024 engage with engagement members 1029 of radial pins 1028 in a snap-fit mechanism to restrain the ring elements 1022 in the collapsed configuration. The ring elements 1022 may be connected to the elongate member 1021 by ring connecting tethers (not shown). The snap-fit mechanism restrains the retrieval device 1020 in the collapsed configuration when advancing through the microcatheter (not shown).
(87) FIGS. 15a-15c and 16a-16d show a method for using a mechanical clot retrieval device 1040 in accordance with the preferred embodiment shown in FIGS. 14a-14c. A guidewire 1003 is inserted in a cerebral artery 1001 and is advanced across an obstructive clot 1002. An intravascular microcatheter 1004 is advanced over the guidewire 1003 to a location proximal to the clot 1002 and then a mechanical clot retrieval device 1004 is advanced through the microcatheter 1004 to the clot 1002 in a collapsed configuration. The retrieval device 1004 includes an elongate member 1041 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of radical pins 1048, and a plurality of ring elements 1042 arranged at the distal end 1046 of the elongate member 1041. The ring elements 1042 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 1042 toward the expanded configuration. Each ring element 1042, comprising a plurality of struts 1043, is made of shape memory material nitinol and each strut features a crown element 1047 with an eyelet 1044. The eyelets 1044 engage with the radial pins 1048 to attach the ring elements to the elongate member. The radial force is absorbed by radial pins to restrain the ring elements 1042 in the collapsed configuration. When microcatheter 1004 is retracted the ring elements 1042 are able to expand and disengage eyelets 1044 from pins 1048 and are thus freed to expand towards the fully expanded configuration. The ring elements 1042 engage or capture the clot and the device can then be retracted proximally and removed from the artery. In one embodiment the ring elements are connected to the elongate member 1041 by tether elements 1045 as shown in FIGS. 16c and 16d.
(88) Another preferred embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 17a-17d. The retrieval device 1520 includes an elongate member 1521 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery, an outer tube 1530 with a plurality of slots 1532 and a retractable inner core wire 1531 which has a proximal end that extends exterior of the artery, and a plurality of ring elements 1522 configured at the distal end of the elongate member 1521. The ring elements 1522 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 1522 toward the expanded configuration. Each ring element 1522 comprising a plurality of struts 1523 is made of shape memory material nitinol and is interconnected by ring connecting tethers 1525. Each strut 1523 has a crown element 1527 with an eyelet 1524. A tether is advanced out of the slot 1532 to loop 1528 through the eyelet 1524 and advanced back in the slot 1532 to loop 1526 around the core wire 1531 to engage each ring element 1522 to the elongate member 1521 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1520 in the collapsed configuration when advancing through a microcatheter (not shown). The core wire 1531 is retracted proximally thus disengaging and allowing each ring element 1522 reach the expanded configuration.
(89) FIGS. 18a-18c depict a mechanical clot retrieval device 1540 of the present invention which is a variant of the retrieval device 1520 as illustrated in FIGS. 17a-17d. FIG. 18d is a view of a cross-section through line 1553 of FIG. 18b. The retrieval device 1540 includes an elongate member 1541 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery, an outer tube 1550 with a plurality of slots 1552 and a retractable inner core wire 1551 having proximal end 1549 that extends exterior of the artery, and a plurality of ring elements 1542 arranged at the distal end of the elongate member 1541. The ring elements 1542 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 1542 toward the expanded configuration. Each ring element 1542, comprising a plurality of struts 1543, is made of shape memory material nitinol and is interconnected by ring connecting tethers (not shown). Each strut 1543 has a crown element 1547 with an eyelet 1544. The core wire 1551 is advanced out of each slot 1552 to loop 1546 through each eyelet 1544 and advanced back in the slot 1552 to loop inside the outer tube 1550 to engage each ring element 1542 to the elongate member 1541 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1540 in the collapsed configuration when advancing through a microcatheter (not shown). The core wire 1551 is retracted in order to disengage and allow each ring element 1542 reach the expanded configuration.
(90) FIGS. 19a-19d represents a mechanical clot retrieval device of the present invention which is yet another slightly variant embodiment of the retrieval device 1520 as illustrated in FIGS. 17a-17d. The retrieval device 1560 includes an elongate member 1561 having a distal end 1569 that extends interior of the artery, a proximal end that extends exterior of the artery and a tube lumen 1570 with a plurality of slots 1571, and a plurality of ring elements 1562 configured at the distal end of the elongate member 1561. The ring elements 1562 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 1562 toward the expanded configuration. Each ring element 1562, comprising a plurality of struts 1563, is made of shape memory material nitinol and is interconnected by ring connecting tethers 1565. Each strut 1563 has a crown element 1568 with an eyelet 1564. A plurality of tethers 1566 is positioned within the lumen 1570 and is advanced out of each slot 1571 to loop 1567 each eyelet 1564 and is attached at a distal end 1569 of the elongate member 1561 to engage each ring element 1562 to the elongate member 1561 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1560 in the collapsed configuration when advancing through a microcatheter (not shown). The tethers 1566 are broken or cut to disengage and allow each ring element 1562 reach an expanded configuration.
(91) FIGS. 20a-20b shows a mechanical clot retrieval device 1580 of the present invention. The retrieval device 1580 includes an elongate member 1581, a distal end 1569 that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 1582 configured at the distal end of the elongate member 1581 and a proximal collar 1589 attached to an abutment tube 1588. The ring elements 1582 are self-expandable from a collapsed configuration to an expanded configuration and feature a radial force that biases the ring elements 1582 toward the expanded configuration. Each ring element 1582, comprising a plurality of struts 1583, is made of shape memory material nitinol and is attached to the elongate member 1581 by connecting tethers 1585. Each strut 1583 has a crown element 1587. A tether is wrapped around each ring element 1582 and is attached to the elongate member 1581 by a tether loop 1584 to engage each ring element 1582 to the elongate member 1581 in a tether-loop mechanism. The radial force is absorbed by the tether-loop mechanism to restrain the retrieval device 1580 in the collapsed configuration when it is advancing through a microcatheter (not shown). The elongate member 1581 is retracted proximally thus sliding the tether loop 1584 off the ring element 1582 and disengaging and therefore allowing each ring element 1582 reach the expanded configuration.
(92) Another preferred embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 21a-21f. The retrieval device 2020 includes an elongate member 2021 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 2022 configured at the distal end of the elongate member 2021, and a plurality of beveled 2029 or recessed 2028 collars 2026 configured at distal and proximal ends of each ring element 2022. The ring elements 2022 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2022 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by collars 2026. Each ring element 2022, comprising a plurality of struts 2023, is made of shape memory material nitinol and is interconnected by tethers (not labeled) and attached to the elongate member 2021 by ring connecting tethers 2025. Each strut 2023 includes a crown element 2027 with a tab 2024 extending axially and radially inward and may be bevel or square shape in shape. The tab 2024 engages with the collar 2026 to restrain the ring element 2022 to the elongate member 2021 in a collar mechanism. The collar mechanism restrains the retrieval device 2020 in the collapsed configuration when advancing through a microcatheter (not shown). The elongate member 2021 is retracted proximally to disengage it and allow each ring element 2022 reach the expanded configuration.
(93) FIGS. 22a-22d shows a method for using the device 2020 in accordance with the preferred embodiment shown in FIGS. 21a-21f A guidewire (not shown) is inserted in a cerebral artery 2000 and is advanced across an obstructive clot 2001. An intravascular microcatheter 2003 is advanced over the guidewire to a location proximal to the clot 2001 and then a mechanical clot retrieval device 2020, sheathed within a bumper tube 2030, is advanced through the microcatheter 2003 to the clot 2001 in a collapsed configuration. The microcatheter 2003 is retracted when the retrieval device 2020 is located distal of the clot. It is unsheathed to allow ring elements 2022 to reach the expanded configuration. The elongate member 2021 of the retrieval device 2020 allows the physician to manually disengage the collar mechanism and the ring connecting tether 2025 attached to the elongate member 2021. The ring elements 2022 engage or capture the clot 2001 from the distal surface of the clot 2001 and retract the clot 2001 proximally to the microcatheter 2003.
(94) FIGS. 23a-23c depicts a mechanism used in a mechanical clot retrieval device 2040 for engaging a tab 2044 with a collar 2046 in a slight variant with the preferred embodiment shown in FIGS. 21a-21f. The retrieval device 2040 includes an elongate member 2041 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a ring element 2042 configured at the distal end of the elongate member 2041 and a proximal collar 2046. The ring element 2042 is self-expandable from a collapsed configuration to an extended configuration and has a radial force that biases the ring element 2042 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the proximal collar 2046. The ring element 2042, comprising plurality of struts 2043, is made of shape memory material nitinol and each strut 2043 has a crown element 2047 with a tab 2044 extending axially and radially inward. The tab 2044 is shaped to engage with the collar 2046, having a recess to restrain the ring element 2042 to the elongate member 2041 in a collar mechanism. The collar mechanism restrains the retrieval device 2040 in the collapsed configuration when advancing through a microcatheter (not shown). The elongate member 2041 is retracted proximally to disengage it and allow each ring element 2042 reach the expanded configuration.
(95) FIGS. 24a-24c shows a mechanical clot retrieval device 2060 of the present invention which is a slightly variant embodiment of the retrieval device 2020 as illustrated in FIGS. 21a-21f The retrieval device 2060 includes an elongate member 2061 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 2062 configured at the distal end of the elongate member 2061, and a plurality of collars 2066 having a plurality of holes 2068 configured proximally of each ring element 2062. The ring members 2062 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2062 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by collars 2066. Each ring element 2062, comprising a plurality of struts 2063, is made of shape memory material nitinol and is interconnected by ring connecting tethers 2069. Each strut 2063 has a crown element 2067 with a pin 2064 extending axially and radially inward. The pin 2064 engages with the hole 2068 to restrain the ring elements 2062 to the elongate member 2061 in a collar mechanism. The device includes a pair of cables 2065 having distal ends which are attached to the most proximal ring element 2062 and proximal ends that extend exterior of the artery for manipulation and control by the physician. The collar mechanism restrains the retrieval device 2060 in the collapsed configuration when it is advancing through a microcatheter 2003. The cables 2065 are manually pulled proximally to disengage the collar mechanism and allow each ring element 2062 reach the expanded configuration.
(96) FIGS. 25a-25k represents a mechanical clot retrieval device 2080 of the present invention which is another slightly variant embodiment of the retrieval device 2020 as illustrated in FIGS. 21a-21f. The retrieval device 2080 includes elongate member 2081 a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 2082 configured at the distal end of the elongate member 2081, and a plurality of shaped engagement collars 2085 having a plurality of dove tail grooves 2088 configured proximally of each ring element 2082. The ring elements 2082 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2082 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by collars 2085. Each ring element 2082, comprising a plurality of struts 2083, is made of shape memory material nitinol and is attached to the elongate member 2081 by tethers 2089. Each strut 2083 has a crown element 2087 with a shaped tab 2084 extending axially and radially inward. The shaped tab 2084 engages with the shaped engagement collar 2085 to restrain the ring element 2082 to the elongate member 2081 in a collar mechanism. The collar mechanism restrains the retrieval device 2080 in the collapsed configuration when it is advancing through a microcatheter (not shown). The elongate member 2081 is manually retracted proximally to disengage it and allow each ring element 2082 reach the expanded configuration.
(97) FIGS. 26a-26c represents a slightly variant embodiment of the retrieval device 2080 as represented in FIGS. 25a-25k, having additional ring connecting tethers 2101 interconnecting each ring element 2082.
(98) Another preferred embodiment of a mechanical clot retrieval device 2520 of the present invention is illustrated in FIGS. 27a-27b. The retrieval device 2520 includes an elongate member 2521 having a distal end that extends interior of the artery, a proximal end that ends interior of the artery and an inner lumen 2529 with a plurality of openings (not labeled), and a plurality of ring elements 2522 configured at the distal end of the elongate member 2521. The ring elements 2522 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases ring elements 2522 toward the expanded configuration. Each ring element 2522, comprising a plurality of struts 2523, is interconnected by ring connecting tethers 2525. Each strut 2523 has a crown element 2527 and an engagement tab 2524. A plurality of tether loops 2526 having proximal ends that extend exterior of the lumen 2529 is advanced out of each opening (not opening) to circle the engagement tab 2524 and engage each ring element 2522 to the elongate member 2521 in an eyelet mechanism. The radial force is absorbed by the eyelet mechanism to restrain the retrieval device 2520 in the collapsed configuration when it is advancing through a microcatheter (not shown). The tethers are manually pulled proximally to disengage them and allow each ring element 2522 to reach the expanded configuration.
(99) FIGS. 28a-28b represents a mechanical clot retrieval device 2540 of the present invention which is a slightly variant embodiment of the retrieval device 2520 as illustrated in FIGS. 27a-27b. The retrieval device 2540 includes an elongate member 2541 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of raised tabs 2548, and a plurality of ring elements 2542 configured at the distal end of the elongate member 2541. The ring elements 2542 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 2542 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by raised tabs 2548. Each ring element 2542, comprising a plurality of struts 2543, is interconnected by ring connecting tethers 2545. Each strut 2543 has a crown element and an engagement tab 2544. The engagement tab 2544 engages with the raised tab 2548 to restrain the ring element 2542 to the elongate member 2541 in an eyelet mechanism. The eyelet mechanism restrains the retrieval device 2540 in the collapsed configuration when it is advancing through a microcatheter (not shown). The elongate member 2541 is manually retracted proximally to disengage it and allow each ring element 2542 to reach the expanded configuration.
(100) FIGS. 29a-29h shows a method for using a mechanical clot retrieval device 2560 in accordance with the preferred embodiment shown in FIGS. 27a-27b and 28a-28b. A guidewire 2502 is inserted in a cerebral artery 2500 and is advanced through an obstructive clot 2501. An intravascular microcatheter 2503 is advanced over the guidewire 2502 to a location distal to the clot 2501 and then the retrieval device 2560 is advanced through the microcatheter 2503 to the clot 2501 in a collapsed configuration. The microcatheter 2503 is retracted when the retrieval device 2560 is positioned distal of the clot 2501 to allow a plurality of ring elements 2562 to reach an expanded configuration. The ring elements 2562, comprising a plurality of struts 2563, are interconnected by ring connecting tethers 2565. A tether 2564 is attached at a distal end of the retrieval device 2560 and its proximal end extends out of the artery. The elongate member 2561 and tether 2564 allows the physician to manually disengage eyelet mechanism. The ring elements 2562 engage or capture the clot 2501 from the distal end of the clot 2501 and retract the clot 2501 proximally to the microcatheter 2504.
(101) Another embodiment of a mechanical clot retrieval device 3020 of the present invention is illustrated in FIGS. 30a-30e. The retrieval device 3020 includes an elongate member 3021 designed to have a distal end that extends interior of the artery, a proximal end that extends exterior of the artery, a plurality of engagement diameters 3028 and a plurality of disengagement diameters 3029, a plurality of ring elements 3022 configured at the distal end of the elongate member 3021, and a proximal abutment tube 3031. The ring elements 3022 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3022 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the engagement diameters. Each ring element 3022 comprising a plurality of struts 3023 is interconnected by ring connecting tethers 3025. Each strut 3023 has a crown element 3027 with a C-shaped engagement tab 3030 extending radially inward. The C-shaped engagement tab 3030 engages with the engagement diameter 3028 to restrain the ring element 3022 to the elongate member 3021 in the collapsed configuration when it is advanced through a microcatheter (not shown). The device features a pair of control tethers 3026 having distal ends which are attached to the crown element 3027 of the most proximal ring element 3022. The axial movement of the elongate member 3021 disengages each ring element 3022 at the disengagement diameter 3029 and allows each ring element 3022 to reach the expanded configuration.
(102) FIGS. 31a-31e shows a mechanical clot retrieval device 3040 of the present invention which is a slightly variant embodiment of the retrieval device 3020 as illustrated in FIGS. 30a-30e. The retrieval device 3040 includes an elongate member 3041 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and an inner wire 3051, a plurality of ring elements 3042 arranged at a distal end of the elongate member 3041, and a proximal abutment tube 3052. The ring elements 3042 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3042 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member having inner wire 3051. Each ring element 3042 comprising a plurality of struts 3042 is interconnected by ring connecting tethers 3045. Each strut 3043 has a crown element 3047 with a C-shaped engagement tab 3050 extending radially inward. The C-shaped engagement tab 3050 engages with the elongate member 3041. The inner wire 3051 restrains the retrieval device 3040 in the collapsed configuration when it is advanced through a microcatheter (not shown). The device features a pair of control tethers 3046 having distal ends which are attached to the crown element 3047 of the most proximal ring element 3042 and proximal ends which are attached to the abutment tube 3052. The withdrawal of the inner wire 3051 disengages it and allows each ring element 3042 reach the expanded configuration.
(103) FIGS. 32a-32d illustrates the mechanical clot retrieval device 3060 of the present invention. The retrieval device 3060 includes an elongate member 3061 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and an inner lumen 3071 with a plurality of slots 3070, a plurality of ring elements 3062 configured at the distal end of the elongate member 3061, and a proximal collar 3066. The ring elements 3062 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3062 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by slots 3070. Each ring element 3062, comprising a plurality of struts 3063, is interconnected by ring connecting tethers 3065. Each strut 3063 has a crown element 3067 with a stepped engagement tab 3064 extending longitudinally and radially. The engagement tab 3064 engages with the slot 3070 to restrain the ring elements 3062 to the elongate member 3061 and to restrain the retrieval device 3060 in the collapsed configuration when it is advanced through a microcatheter (not shown). A pair of control tethers 3068 is attached from the crown element 3067 of the most proximal ring element 3062, to the proximal collar 3066. The proximal collar 3066 is manually pulled proximally to disengage it and allow the ring elements 3062 to reach an expanded configuration.
(104) FIGS. 33a-33g represents another embodiment of a mechanical clot retrieval device of the present invention. The retrieval device 3080 includes an elongate member 3081 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of monofilaments 3088, a plurality of ring elements 3082 configured at the distal end of the elongate member 3081, and a proximal collar 3086. The ring elements 3082 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 3082 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the monofilaments. Each ring element 3082 comprising a plurality of struts 3083 is interconnected by ring connecting tethers 3085. Each strut 3082 has a crown element 3087 with a C-shaped engagement tab 3084. The C-shaped engagement tab 3084 engages with the monofilament 3088 to restrain the ring element 3082 to the elongate member 3081 in a snap-fit mechanism. The snap-fit mechanism restrains the retrieval device 3080 in the collapsed configuration when it is advancing through a microcatheter (not shown). The device contains a pair of control tethers 3089 having distal ends which are attached to the crown element 3087 of the most proximal ring element 3082 and proximal ends which are attached to the collar 3086. The elongate member 3081 is manually retracted to disengage it and allow each ring element 3082 reach the expanded configuration.
(105) Another embodiment of a mechanical clot retrieval device of the present invention is shown in FIGS. 34a-34j. The retrieval device 3100 includes an elongate member 3101 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of inactivated cuffs 3108a configured at the distal end of the elongate member 3101, a plurality of ring elements 3102 configured over the cuff 3108a, and a tube 3106. Each cuff 3108a is made of electro-active polymer which swells to an activated state 3108b when current is applied. The ring elements 3102 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 3102 toward the expanded configuration. Each ring element 3102 comprising a plurality of struts 3103 is interconnected by ring connecting tethers 3105. Each strut has a crown element 3107. A pair of control tethers 3104 are attached to the crown element 3107 of the most proximal ring element 3102, having proximal ends that extend out of the artery. A ring restraining tether 3109 is wrapped around each ring element 3102 restraining it to the elongate member 3101 in the collapsed configuration when it is advanced through a microcatheter (not shown). In the collapsed configuration, the radial force is absorbed by the ring restraining tethers 3109. The current is applied through the restraining tether 3109 to allow each cuff 3108a to reach activated state 3108b and then they are manually pulled proximally to disengage them and allow each ring element 3102 reach the expanded configuration.
(106) FIGS. 35a-35b represents another embodiment of a mechanical clot retrieval device of the present invention. The retrieval device 3120 includes an elongate member 3121 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3122 configured at the distal end of the elongate member 3121, a proximal collar 3129, and a bumper tube 3126. The ring elements 3122 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force biasing the ring elements 3122 toward the expanded configuration. Each ring element 3122, comprising a plurality of struts 3123, is interconnected by ring connecting tethers 3125. Each strut 3123 has a crown element 3127 with an eyelet 3128. A tether loop 3130 engages each ring element 3122 to the elongate member 3121 to restrain the retrieval device 3120 in the collapsed configuration when it is advancing through a microcatheter 3003. In the collapsed configuration, the radial force is absorbed by tether loops 3130. The device contains a pair of control tethers 3124, having distal ends which are attached to the crown element 3127 of the most proximal ring element 3122 and proximal ends which extend out of the artery. The elongate member 3121 is manually retracted proximally to disengage it and allow each ring element 3122 reach the expanded configuration.
(107) Another embodiment of a mechanical clot retrieval device of the present invention is shown in FIGS. 36a-36d. The retrieval device 3140 includes an elongate member 3141 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3142 arranged at the distal end of the elongate member 3141, a bumper tube 3146 and a proximal collar 3149. The ring elements 3142 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing ring elements toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 3141. Each ring element 3142 comprising a plurality of struts 3143 is interconnected by ring connecting tethers 3145. Each strut 3143 has a crown element 3147 with an engagement tab 3148 having an eyelet 3144. The elongate member 3141 passes through each eyelet 3144 engaging each ring element 3142 to the elongate member 3141 to restrain the retrieval device 3140 in the collapsed configuration when it is advancing through a microcatheter 3003. The elongate member 3141 is manually retracted proximally to disengage it and allow each ring element 3142 reach the expanded configuration.
(108) FIGS. 37a-37i represents a mechanical clot retrieval device of the present invention which is a slightly variant embodiment of the retrieval device 3140 as shown in FIGS. 36a-36d. The retrieval device 3160 includes an elongate member 3161 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3162 configured at the distal end of the elongate member 3161, a bumper tube (not labeled) and a proximal collar (not labeled). The ring elements 3162 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force biasing the ring elements 3162 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 3161. Each ring element 3162 comprising a plurality of struts 3163 is interconnected by ring connecting tethers (not labeled). Each strut has a crown element 3167 with an engagement tab 3166 and an eyelet 3168. The elongate member 3161 passes through each eyelet 3168 engaging each ring element 3162 to the elongate member 3161 to restrain the retrieval device 3160 in the collapsed configuration when it is advancing through a microcatheter 3003. The elongate member 3161 is manually retracted proximally to disengage and allow each ring element 3162 reach the expanded configuration.
(109) Another embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 38a-38d. The retrieval device 3200 has an elongate member 3201 having a distal end that extends interior of the artery, a proximal end that extends exterior of the artery and a plurality of restraining loops 3206 configured at the distal end of the elongate member 3201, and a plurality of ring elements 3202 arranged at the distal end of the elongate member 3201. The ring elements 3202 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3202 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the restraining loops 3206. Each ring element 3202 comprising a plurality of struts 3203 is connected to the loop 3206 by connecting tethers 3205. Each strut 3203 is having a crown element 3207. The device features a pair of control tethers 3204, having distal ends which are attached to the crown element 3207 of the most proximal ring element 3202, and proximal ends that extend out of the artery. The loops 3206 engage the ring elements 3202 to the elongate member 3201 in an offset loop mechanism. The offset loop mechanism restrains the retrieval device 3200 in the collapsed configuration when it is advanced through a microcatheter (not shown). The elongate member 3201 is manually retracted proximally to disengage it and allow each ring element 3202 to reach the expanded configuration.
(110) Another embodiment of a mechanical clot retrieval device 3300 of the present invention is illustrated in FIGS. 39a-39d. The retrieval device 3300 has an elongate member 3301 having a distal end that extends interior of the artery and a proximal end that extend exterior of the artery, a plurality of ring elements 3302 arranged at the distal end of the elongate member 3301, a bumper tube 3306, and a proximal collar 3308. The ring elements 3302 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by the elongate member 3301. Each ring element 3302, comprising a plurality of struts 3303, is interconnected by ring connecting tethers 3305. Each strut 3303 has a crown element 3307. The device has comprises a pair of control tethers 3304, having distal ends which are attached to the crown element 3307 of the most proximal ring element 3302 and proximal ends that are attached to the bumper tube 3306. The crown element 3307 of each strut 3303 is confined around the elongate member 3301 to restrain the ring element 3302 to the elongate member 3301 when it is advanced through a microcatheter 3309. The elongate member 3301 is retracted proximally to disengage it and allow each ring element 3302 to reach the expanded configuration.
(111) FIGS. 40a-40e and 41a-41d shows a method of advancing a mechanical clot retrieval device 3405 in accordance with a preferred embodiment of the present invention in a tortuous vessel 3400. A guidewire 3402 is inserted in the vessel 3400 and is advanced through an obstructive clot 3401. An intravascular microcatheter 3403 is advanced over the guidewire to a location distal to the clot 3401 and then the retrieval device 3405 is advanced through the microcatheter 3403 to the clot 3401 in a collapsed configuration. The microcatheter 3403 is retracted to allow the plurality of ring elements (not labeled) to reach an expanded configuration. The ring elements (not labeled) contain a plurality of struts (not labeled). Each ring element is connected to the next ring element (not labeled) by a ring connecting tether 3406. A control tether 3407 is attached to the strut (not labeled) of the proximal ring element having a proximal end that extends out of the patient to allow physician to manually maneuver the retrieval device 3405. The retrieval device 3405 engages or captures the clot 3401 from the distal end of the clot 3401 and retracts the clot 3401 proximally into the microcatheter 3403.
(112) FIGS. 42a-42d, 43a-43h and 44a-44b illustrates the mechanical clot retrieval device 3420 of the present invention. The retrieval device 3420 includes an elongate member 3421 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, and a plurality of ring elements 3422 configured at the distal end of the elongate member 3421. The ring elements 3422 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3422 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3420 is delivered inside the artery. Each ring element 3422, comprising a plurality of struts 3423, is interconnected by ring connecting tethers 3425. Each strut 3423 has a crown element 3427 with or without a shaped tab 3428 or an eyelet 3426. The crown element 3427 is connected to neighboring crown element 3427 by the tether 3425 which may be looped around tab 3428 or passed through eyelet 3426.
(113) The crown element 3427 which is without the shaped tab 3428 or the eyelet 3426 may be connected to neighboring crown element 3427 by an adhesive bond 3429. Crown-to-crown 3427 connection restrains the retrieval device 3420 in the collapsed configuration when advanced through the intravascular microcatheter (not shown). The device features a pair of removal tethers 3424, having distal ends which are attached to the crown element 3427 of the most proximal ring element 3422, and proximal ends that extend out of the artery. The microcatheter is retracted proximally and tether 3424 is manually pulled proximally to disengage it and allow each ring element 3422 reach the expanded configuration.
(114) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 45. The retrieval device 3440 has an elongate member 3441 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3442 having a first diameter and a second diameter, and a control strut 3444 having distal end attached to proximal ring element 3442 and proximal end attached to the elongate member 3441 by adhesive bonds 3446. The ring elements 3442 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3442 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3440 is delivered inside the artery. Each ring element 3442, comprising a plurality of struts 3443, is connected by ring connecting tethers 3445. Each strut 3443 has a crown element 3447. The crown element 3447 is connected to neighboring crown element 3447 by the tether 3445. Crown-to-crown connection restrains the retrieval device 3440 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3442 disengages to create a zigzag stent surface for improved clot engagement.
(115) FIG. 46 represents a mechanical clot retrieval device 3460 of the present invention which is a slightly variant embodiment of the retrieval device as illustrated by FIG. 46. The retrieval device 3460 has an elongate member 3461 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3462 attached at the distal end of the elongate member and a control strut 3464 having a distal end attached to the most proximal ring element 3462 and a proximal end attached to the elongate member 3461 by adhesive bonds 3466. The ring elements 3462 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3460 is delivered inside the artery. Each ring element 3462, comprising a plurality of struts 3463, is connected by ring connecting tethers 3465. Each strut 3463 has a crown element 3467. The crown element 3467 is connected to the neighboring crown 3467 by a connecting strut 3468 to restrain the retrieval device 3460 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3462 disengages to create a zigzag stent surface for improved clot engagement.
(116) FIG. 47 represents a mechanical clot retrieval device 3480 of the present invention which is another variant embodiment of the retrieval device as illustrated in FIG. 46. The retrieval device 3480 has an elongate member 3481 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3482 and a control strut 3484 having a distal end attached to the proximal ring element 3482 and a proximal end attached to the elongate member 3481. The ring elements 3482 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3482 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter, through which the retrieval device 3480 is delivered inside the artery. Each ring element 3482, comprising a plurality of struts 3483, is connected by ring connecting tethers 3485. Each strut 3483 has a crown element 3487. The crown element 3487 is connected to the neighboring crown 3487 by the tether 3485 and adhesive bond 3486. Crown-to-crown connection restrains the retrieval device 3480 in the collapsed configuration when it is advanced through a microcatheter (not shown). The microcatheter is retracted and each ring element 3482 disengages to create a zigzag stent surface for improved clot engagement.
(117) Another preferred embodiment of a mechanical clot retrieval device of the present invention is illustrated in FIGS. 48a-48f. The retrieval device 3500 includes an elongate member 3501 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3502, and a pair of removal tethers 3504 having distal ends attached to the proximal ring element 3502 and proximal ends attached to the elongate member 3501. The ring elements 3502 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3502 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403, through which the retrieval device 3500 is delivered inside the artery. Each ring element 3502, comprising a plurality of struts 3503, is interconnected by ring connecting tethers 3505. Each strut 3503 has a crown element 3507. The distally facing crown element 3507 is connected to the neighboring proximally facing crown 3507 by the tether 3505. Crown-to-crown connection restrains the retrieval device 3500 in the collapsed configuration when advanced through the microcatheter 3403. The microcatheter 3403 is advanced inside a torturous artery 3400 and is positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3502 reach the expanded configuration and engage or capture the clot 3401 from the distal end of the clot 3401 and the device is then retracted proximally into the microcatheter 3403.
(118) FIGS. 49a-49f represents a mechanical clot retrieval device of the present invention which is a slightly variant embodiment of the retrieval device 3500 as illustrated in FIGS. 48a-48f The retrieval device has an elongate member 3521 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3522, and a control strut 3524 having a distal end attached to the proximal ring element 3522 and a proximal end attached to the elongate member 3521. The ring elements 3522 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3522 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3520 is delivered inside the artery. Each ring element 3522, comprising a plurality of struts 3523, is connected by ring connecting tethers 3525. Each strut 3523 has a crown element 3527. The distally facing crown element 3527 is connected to neighboring proximally facing crown 3527 by the tether 3525. Crown-to-crown 3527 connection restrains the retrieval device 3520 in the collapsed configuration when advanced through the microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a torturous artery 3400 and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted proximally to allow each ring element 3522 reach the expanded configuration and engage or capture the clot 3401 from the distal end of the clot 3401 and the device is then retracted proximally into the microcatheter 3403.
(119) FIGS. 50a-50g shows a mechanical clot retrieval device 3540a of the present invention which is another slightly variant embodiment of the retrieval device 3500 as illustrated in FIGS. 48a-48f. The retrieval device 3540a includes an elongate member 3541 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3542 configured at the distal end of the elongate member 3541 and a plurality of connecting tethers 3545 having distal ends attached to the ring element 3542 and proximal ends attached to the elongate member 3541. The ring elements 3542 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3542 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3540a is delivered inside the artery. Each ring element 3542 comprising a plurality of struts 3543. Each strut 3543 has a crown element 3547. The distally facing crown element 3547 is connected to neighboring proximally facing crown 3547 by the tether 3545. Crown-crown 3547 connection restrains the retrieval device 3540a in the collapse configuration when advanced through a microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a tortuous artery 3400 and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3542 to reach the expanded configuration and engage or capture the clot 3401 from the distal base of the clot 3401 and the device is then retracted proximally to the microcatheter 3403.
(120) Another embodiment of a mechanical clot retrieval device 3560 of the present invention is illustrated in FIGS. 51a-51f The retrieval device 3560 includes an elongate member 3561 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3562 configured at the distal end of the elongate member 3561, a plurality of connecting tethers 3565 having distal ends attached to the ring element 3562 and proximal ends attached to the elongate member 3561, and a pair of removal tethers 3564 having distal ends attached to the most proximal ring element 3562 and proximal ends that extend out of the artery. The ring elements 3562 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3562 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3560 is delivered inside the artery. Each ring element 3562 comprises a plurality of struts 3563. Each strut 3563 has a crown element 3567. The connecting tether 3565 engages each ring element 3562 to the elongate member 3562 to restrain the retrieval device 3560 in the collapsed configuration when it is advanced through a microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a tortuous artery 3400 and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3562 reach the expanded configuration and engage or capture the clot 3401 from the distal base of the clot 3401 and retracted proximally to the microcatheter 3403.
(121) FIGS. 52a-52d represents a mechanical clot retrieval device 3580 of the present invention which is a slightly variant embodiment of the retrieval device 3560 as illustrated in FIGS. 51a-51f. The retrieval device 3580 has an elongate member 3581 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3582 configured at the distal end of the elongate member 3581 and a plurality of connecting tethers 3585 having distal ends attached to the ring member 3582 and proximal ends attached to the elongate member 3581. The ring elements 3582 are self-expandable from a collapsed configuration to an expanded configuration and comprise a radial force that biases the ring elements 3582 towards the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3403 through which the retrieval device 3580 is delivered inside the artery. Each ring element 3582 comprises a plurality of struts 3583. Each strut 3583 has a crown element 3587. Each ring element 3582 is wrapped around the elongate member 3581 to restrain the retrieval device 3580 in the collapsed configuration when it is advanced through a microcatheter 3403. The microcatheter 3403 is advanced over a guidewire (not shown) inside a tortuous artery and positioned distal of an obstructive clot 3401. The microcatheter 3403 is retracted to allow each ring element 3582 to reach the expanded configuration and engage or capture the clot 3401 from the distal base of the clot (not shown) and then the device is retracted proximally into the microcatheter 3403.
(122) FIGS. 53a-53f shows a method of using a mechanical clot retrieval device 3600 of the present invention in the embodiment as illustrated in FIGS. 52a-52d. A guide catheter 3601 is inserted inside the artery and a guidewire (not shown) is advanced within the catheter 3601 bypassing an occlusive clot (not shown). A microcatheter 3602 is advanced over the guidewire (not shown) to a location distal to the clot (not shown) and then the retrieval device 3600 is advanced through the microcatheter 3602 to the clot (not shown) in a collapsed configuration. The microcatheter 3602 is retracted to allow ring elements 3604 to reach an expanded configuration. The ring elements 3604 are self-expandable from the collapsed configuration to the expanded configuration and each ring element comprises plurality of struts 3605. Each strut 3605 has a crown element 3607. The ring elements 3604 are attached to the elongate member 3603 by connecting tethers 3606 and are wrapped around the elongate member 3603 to restrain the retrieval device 3600 in the collapsed configuration when it is advanced through the microcatheter 3602. The ring elements 3604, when expanded, engage or capture the clot (not shown) from the distal base of the clot (not shown) and retract the clot (not shown) proximally to the microcatheter 3602. The retrieval device 3600 returns to the collapsed configuration while retracting into the guide catheter 3601 and is easily removed from the artery.
(123) FIGS. 54a-54h shows another method of using a mechanical clot retrieval device 3620 of the present invention in accordance with the embodiment as illustrated in FIGS. 52a-52d. A guidewire 3404 is inserted in a tortuous artery 3400 and advanced through an obstructive clot 3401. A microcatheter 3403 is advanced over the guidewire 3404 to a location distal to the clot 3401 and then the retrieval device 3620 is advanced through the microcatheter 3403 to the clot 3401 in a collapsed configuration. The microcatheter 3403 is retracted when the retrieval device 3620 is positioned distal of the clot 3401 to allow ring elements 3622 to reach an expanded configuration. The ring elements 3622 are self-expandable from the collapsed configuration to the expanded configuration and are wrapped around the elongate member 3621 to restrain the retrieval device 3620 in the collapsed configuration when advanced through the microcatheter 3403. A removal tether 3624 is attached to the retrieval device 3620. The ring elements 3622, when expanded using an activation element 3626, engage or capture the clot 3401 from the distal base of the clot 3401 and retract the clot 3401 proximally to the microcatheter 3603. The retrieval device 3620 returns to the collapsed configuration while retracting into a guide catheter 3627 and is easily removed from the artery 3400.
(124) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 55. The retrieval device 3700 has an elongate member 3701 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3702a having a larger diameter and a plurality of ring elements having a smaller diameter 3702b, and a control strut 3704 having distal end attached to proximal ring element 3702a and proximal end attached to the elongate member 3701 by adhesive bonds 3706. The ring elements 3702a and 3702b are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3702a and 3702b toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3700 is delivered inside the artery. Each ring element 3702a, and 3702b comprises a plurality of struts 3703. Each strut 3703 has a crown element 3707. The crown element 3707 is connected to neighboring crown element 3707 by the ring to ring connection 3705. The ring to ring connection 3705 restrains the retrieval device 3700 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3702 disengages to form the expanded configuration.
(125) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 56. The retrieval device 3720 has an elongate member 3721 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3722, and a removal tether 3724 having distal end attached to proximal ring element 3722 and proximal end attached to the elongate member 3721. The ring elements 3722 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3722 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3720 is delivered inside the artery. Each ring element 3722 comprises a plurality of struts 3723. The outer mesh 3725 restrains the retrieval device 3720 and limits it to a certain diameter in the expanded configuration. The microcatheter is retracted proximally and each ring element 3722 disengages to form the maximum allowable diameter within the outer mesh.
(126) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 57. The retrieval device 3740 has an elongate member 3741 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3742, and a removal tether 3744 having distal end attached to proximal ring element 3742 and proximal end attached to the elongate member 3741. The ring elements 3742 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3742 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3740 is delivered inside the artery. Each ring element 3742 comprises a plurality of struts 3743. The tether net cover 3745 restrains the retrieval device 3740 and limits it to a certain diameter in the expanded configuration. The microcatheter is retracted proximally and each ring element 3742 disengages to form the maximum diameter allowed by the tether net cover.
(127) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 58. The retrieval device 3760 has an elongate member 3761 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3762, and a control strut 3764 having distal end attached to proximal ring element 3762 and proximal end attached to the elongate member 3761 by adhesive bonds 3766. The ring elements 3762 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3762 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3760 is delivered inside the artery. Each ring element 3762 comprises a plurality of struts 3763. Each strut 3763 has a crown element 3767. The crown element 3767 is connected to neighboring crown element 3767 by the ring to ring connection 3765. The ring to ring connection 3765 restrains the retrieval device 3760 in the collapsed configuration when it is advanced through the microcatheter (not shown). The microcatheter is retracted proximally and each ring element 3762 disengages to form the expanded configuration.
(128) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 59. The retrieval device 3780 has an elongate member 3781 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3782, and a removal tether 3784 having distal end attached to proximal ring element 3782 and proximal end attached to the elongate member 3781. The ring elements 3782 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3782 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3780 is delivered inside the artery. Each ring element 3782 comprises a plurality of struts 3783. The tether net cover 3785 restrains the retrieval device 3780 and limits it to a certain diameter in the expanded configuration. The device also comprises a tapered ring element at the distal end of the tether net cover 3785. The microcatheter is retracted proximally and each ring element 3782 disengages to form the maximum diameter allowed by the tether net cover 3785.
(129) Another embodiment of a mechanical clot retrieval device of the present invention is represented in FIG. 60. The retrieval device 3800 has an elongate member 3801 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a plurality of ring elements 3802, and a control strut 3804 having distal end attached to proximal ring element 3802 and proximal end attached to the elongate member 3801 by adhesive bonds 3806. The ring elements 3802 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3802 toward the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter (not shown) through which the retrieval device 3780 is delivered inside the artery. Each ring element 3802 comprises a plurality of struts 3803. Each strut 3803 has a crown element 3807. The crown element 3807 is connected to neighboring crown element 3807 by the ring to ring connection 3805. The ring to ring connection 3805 restrains the retrieval device 3800 in the collapsed configuration when it is advanced through the microcatheter (not shown). The ring elements are wrapped in an outer mesh/net cover 3808 which limits the diameter of the ring elements in the expanded configuration. The microcatheter is retracted proximally and each ring element 3802 disengages to form the expanded configuration with the maximum diameter allowed by the outer mesh/net cover 3808.
(130) Another preferred embodiment of a mechanical clot retrieval device 3820 of the present invention is illustrated in FIGS. 61a-61c. The retrieval device 3820 is advanced through a microcatheter 3821 inside the patient artery and includes an activation tether 3824, having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3827, and a plurality of ring elements 3822 configured to the distal end of the activation tether 3824. The ring elements 3822 are self-expandable from a collapsed configuration to an expanded configuration and have a radial force that biases the ring elements 3822 in the expanded configuration. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3821 through which the retrieval device 3820 is delivered inside the artery. Each ring element 3822, comprising a plurality of struts 3823, is interconnected by bridges 3825. The microcatheter 3821 is retracted and the activation tether 3824 is manually pulled proximally to compress the device and allow ring elements 3822 to reach the expanded configuration.
(131) FIGS. 62a-62b shows a mechanical clot retrieval device 3840 of the present invention which is a slightly variant embodiment of the retrieval device as illustrated in FIGS. 61a-61c. The retrieval device 3840 is advanced through a microcatheter 3841 inside the artery and has an activation tether 3844, having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3847, and a ring element 3846 configured at the distal end of the activation tether 3844. The ring element 3846 is self-expandable from a collapsed configuration to an expanded configuration and comprises a radial force that biases the ring element 3846 to the expanded configuration. The ring element comprises a plurality of struts 3843. The microcatheter 3841 is retracted and the activation tether 3844 is manually pulled proximally to compress the device proximally and allow ring elements 3842 to reach the expanded configuration.
(132) FIGS. 63a-63b shows a mechanical clot retrieval device 3860 of the present invention which is a slightly variant embodiment of the retrieval device 3840 as illustrated in FIGS. 62a-62b. The retrieval device 3862 is advanced through a microcatheter 3861 inside the artery and has an activation tether 3864 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3867, a ring element 3866 configured at the distal end of the activation tether 3864, and a pair of removal tethers 3862 attached to the ring element 3866 having proximal ends that extend out of the artery. The ring element 3866 is self-expandable from a collapsed configuration to an expanded configuration and comprises a radial force that biases the ring element 3866 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter. The microcatheter 3861 is retracted and the activation tether 3864 is manually pulled proximally to compress the device proximally and allow ring element 3866 to reach the expanded configuration.
(133) FIGS. 64a-64b shows a mechanical clot retrieval device 3880 of the present invention which is a slightly variant embodiment of the retrieval device 3860 as illustrated in FIGS. 63a-63b. The retrieval device 3882 is advanced through a microcatheter 3881 inside the patient artery and has an activation tether 3884 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a couple of collars 3887, a couple of ring elements 3886 configured at the distal end of the activation tether 3884, and a pair of removal tethers 3882 having distal ends attached to the ring element 3886 and having proximal attached to the collar 3887. The ring element 3886 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3886 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter 3881. Each ring element 3886 comprises a plurality of struts 3883. The microcatheter 3881 is retracted and the activation tether 3884 is manually pulled proximally to compress the device and to allow ring element 3886 reach the expanded configuration.
(134) FIGS. 65a-65d illustrates another preferred embodiment of a mechanical clot retrieval device 3900a of the present invention. The retrieval device 3900a is advanced through a microcatheter 3901 inside the patient artery and has a pair of activation tethers 3904 having distal ends that extend interior of the artery and proximal ends that extend exterior of the artery, a distal collar 3907, and a plurality of ring elements 3902 configured to the distal end of the activation tether 3904. The ring elements 3902 are self-expandable from a collapsed configuration 3900a to an expanded configuration 3900b and have a radial force that biases the ring elements 3902 to the expanded configuration 3900b. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3901 through which the retrieval device 3900a is delivered inside the artery. Each ring element 3902, comprising a plurality of struts 3903, is connected by bridges 3905. Each strut includes a tether guide tube 3908. The distal end of activation tether is passed through the guide tube 3908. The microcatheter 3901 is retracted and the activation tethers 3904 are manually pulled proximally to compress the device proximally and to allow ring elements 3902 to reach the expanded configuration 3900b.
(135) FIGS. 66a-66c illustrates a mechanical clot retrieval device 3920a of the present invention which is a slightly variant embodiment of the retrieval device shown in FIGS. 61a-61c. The retrieval device 3920a is advanced through a microcatheter 3921 inside the patient artery and has a pair of activation tethers 3924 having distal ends that extend interior of the artery and proximal ends that extend exterior of the artery, a distal collar 3927, and a plurality of ring elements 3922 configured to the distal end of the activation tether 3824. The ring elements 3922 are self-expandable from a collapsed configuration 3920a to an expanded configuration 3920b and comprise a radial force that biases the ring elements 3922 in the expanded configuration 3920b. In the collapsed configuration, the radial force is absorbed by an intravascular microcatheter 3921 through which the retrieval device 3920a is delivered inside the artery. Each ring element 3922 comprising a plurality of struts 3923 and a limiting tether 3928 is interconnected by bridges 3925. The microcatheter 3921 is retracted and the activation tether 3924 is manually pulled proximally to compress the device and to allow ring elements 3922 to reach the expanded configuration 3920b. The limiting tether 3928 prevents the ring element from expanding beyond a certain diameter.
(136) FIGS. 67a-67b shows a mechanical clot retrieval device 3940 of the present invention which is a slightly variant embodiment of the retrieval device 3840 as illustrated in FIGS. 62a-62b. The retrieval device 3940 is advanced through a microcatheter 3941 inside the patient artery and has an activation tether 3944 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3947, and a ring element 3946 configured at the distal end of the activation tether 3944. The ring element 3946 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3946 to the expanded configuration. The ring element comprising a plurality of struts 3943 and a limiting tether 3948. The microcatheter 3941 is retracted and the activation tether 3944 is manually pulled proximally to compress the device and to allow ring elements 3942 to reach the expanded configuration.
(137) FIGS. 68a-68b shows a mechanical clot retrieval device 3960 of the present invention which is a slightly variant embodiment of the retrieval device 3860 as illustrated in FIGS. 63a-63b. The retrieval device 3962 is advanced through a microcatheter 3961 inside the artery and has an activation tether 3964 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a distal collar 3967, a ring element 3966 configured at the distal end of the activation tether 3964, and a pair of removal tethers 3962 attached to the ring element 3966 having proximal ends that extend exterior of the artery. The ring element 3966 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3966 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter 3961. Each ring element 3966 comprises a plurality of struts 3963 and a limiting tether 3968. The microcatheter 3961 is retracted and the activation tether 3964 is manually pulled proximally to compress the device and allow ring elements 3966 to reach the expanded configuration.
(138) FIGS. 69a-69b shows a mechanical clot retrieval device 3980 of the present invention which is a slightly variant embodiment of the retrieval device 3880 as illustrated in FIGS. 64a-64b. The retrieval device 3980 is advanced through a microcatheter 3981 inside the artery and has an activation tether 3984 having a distal end that extends interior of the artery and a proximal end that extends exterior of the artery, a couple of collars 3987, a couple of ring elements 3986 configured at the distal end of the activation tether 3984, and a pair of removal tethers 3982 having distal ends attached to the ring element 3986. The ring element 3986 is self-expandable from a collapsed configuration to an expanded configuration and has a radial force that biases the ring element 3986 to the expanded configuration. In the collapsed configuration, the radial force is absorbed by the microcatheter 3981. Each ring element comprises a plurality of struts 3983 and a limiting tether 3988. The microcatheter 3981 is retracted and the activation tether 3984 is manually pulled proximally to compress the device and allow the ring elements 3986 reach the expanded configuration.
(139) The ring elements used in the above description are made of shape-memory material, preferably Nitinol. Remaining elements of the retrieval device as described herein are preferably formed of a material such as a stainless steel, a nickel-based super alloy, a spring steel alloy, particularly a composition sold under the trademark nitinol.
(140) It will be apparent from the foregoing description that, while particular embodiments of the present invention have been illustrated and described, various modifications can be made without departing from the spirit and scope of the invention.
(141) Modifications and additions can be made to the various embodiments of the invention described herein. For example, while embodiments may refer to particular features, the invention includes embodiments having different combinations of features. The invention also includes embodiments that do not include all of the specific features described.
(142) The invention is not limited to the embodiments hereinbefore described which may be varied in construction and detail.
