Abstract
A left atrial appendage occluder comprises an elastic closure disc, and a supporting structure connecting with the closure disc and being located on one side of the closure disc, with the supporting structure comprising a central end connecting with the closure disc and a plurality of interconnected and bent struts, wherein at least one anchoring thorn is set near the end of at least one strut with the anchoring thorn toward the closure disc. The left atrial appendage occluder has a stable structure, a good positioning and sealing effect on the cavity wall in the left atrial appendage, and it is easy to position repeatedly; it can also be recycled before separating from a conveyor. When in surgical operation, the left atrial appendage occluder can select the position area based on the actual shape and size of the patient's left atrial appendage, so the surgical risk is lowered.
Claims
1. A left atrial appendage occluder that is delivered to a left atrial appendage by a sheath that has a wall that defines a lumen, comprising: a closure disc; an elastic fixing frame having a distal end and a proximal end fixed to the closure disc, the fixing frame defining a longitudinal axis, wherein the distal end of the fixing frame extends outwardly from the proximal end and stretches out in a radial direction, and then overturns outwardly towards the proximal end to form a free end when the fixing frame is outside the sheath; and at least one anchor, wherein the fixing frame is located between the at least one anchor and the wall of the sheath with the at least one anchor facing radially inwardly towards the longitudinal axis when the fixing frame is in the sheath during delivery, and when the fixing frame is deployed outside the sheath, the at least one anchor outwardly extends from the fixing frame.
2. The occluder of claim 1, wherein the free end of the fixing frame is adjacent to and spaced from the closure disc.
3. The occluder of claim 1, wherein the closure disc and the fixing frame both have a diameter, and the diameter of the closure disc is larger than the diameter of the fixing frame when the occluder is deployed outside the sheath.
4. The occluder of claim 1, wherein the occluder defines a distal end and a proximal end, and the at least one anchor has a free end, and when the fixing frame is in a sheath, the free end of the at least one anchor faces the distal end of the occluder, and when the fixing frame is deployed outside the sheath, the free end of the at least one anchor faces the proximal end of the occluder.
5. The occluder of claim 1, wherein the fixing frame further comprises at least one tail end at the free end, and at least one bent part is located at the tail end and bent inwardly towards the longitudinal axis of the fixing frame.
6. The occluder of claim 5, wherein the at least one bent part is U-shaped.
7. The occluder of claim 6, wherein each U-shaped bent part overturns 360 degrees when the fixing frame is deployed outside the sheath.
8. The occluder of claim 5, wherein the distal end of the fixing frame has an inner surface that faces the proximal end when the occluder is deployed outside the sheath, and an outer surface that faces radially outwardly from the proximal end when the occluder is deployed outside the sheath, and wherein the at least one anchor is provided on the outer surface.
9. The occluder of claim 5, wherein the at least one tail end of the fixing frame is provided with a bulb.
10. The occluder of claim 1, wherein during delivery of the occluder to a left atrial appendage, the fixing frame is released from the sheath before the closure disc is released.
11. The occluder of claim 1, wherein the closure disc is a mesh with two fixed ends, and a flow blocking membrane is disposed on the closure disc.
12. The occluder of claim 11, wherein the flow blocking membrane is inside of the closure disc.
13. The occluder of claim 11, wherein the flow blocking membrane is made of PET or PTFE material.
14. The occluder of claim 1, wherein the closure disc has a distal end, and the proximal end of the fixing frame is around the outside of the distal end of the closure disc.
15. The occluder of claim 1, wherein the length of the at least one anchor on the fixing frame is 1-2 mm.
16. The occluder of claim 1, wherein the proximal end of the fixing frame further comprises a flexible connection structure, and the fixing frame is connected with the closure disc via the flexible connection structure.
17. The occluder of claim 16, wherein the flexible connection structure is a flexible connector with an elastic spiral.
18. The occluder of claim 16, wherein the flexible connection structure is a multi-strand flexible member.
19. The occluder of claim 1, wherein each of the at least one anchor has a root which is disposed on the fixing frame, and each of the at least one anchor has a free end which is automatically splayed outwardly, and the at least one anchor is retracted back to the fixing frame when it is compressed.
20. The occluder of claim 1, wherein the closure disc and the fixing frame are made of nickel titanium alloy.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) The invention is further described as below with reference to drawings and embodiments. In the drawings,
(2) FIG. 1 is a schematic diagram of a position of a plug type left atrial appendage occluder in an anatomical structure of a heart and a left atrial appendage:
(3) FIG. 2 is a schematic diagram of a position of a plug type left atrial appendage occluder in a left atrial appendage from the direction of the entrance of the left atrial appendage;
(4) FIG. 3 is a schematic diagram of a position of a plug-and-disc type left atrial appendage occluder in an anatomical structure of a heart and a left atrial appendage;
(5) FIG. 4 is a schematic diagram of a position of a left atrial appendage occluder of the invention in an anatomical structure of a heart and a left atrial appendage, in which a fixing frame pins on a deep position of the left atrial appendage;
(6) FIG. 5 is a schematic diagram of a position of a left atrial appendage occluder of the invention in an anatomical structure of a heart and a left atrial appendage, in which a fixing frame pins on a shallow position of the left atrial appendage;
(7) FIG. 6 is a main view of a left atrial appendage occluder according to a first embodiment of the present invention;
(8) FIG. 7 is a top view of a left atrial appendage occluder according to a first embodiment of the present invention;
(9) FIG. 8 is a perspective diagram of a left atrial appendage occluder according to a first embodiment of the present invention;
(10) FIG. 9 is a main view of a left atrial appendage occluder according to a second embodiment of the present invention;
(11) FIG. 10 is a perspective diagram of a left atrial appendage occluder according to a second embodiment of the present invention;
(12) FIG. 11 is a partial enlarged view of part of FIG. 10;
(13) FIG. 12 is a main view of a left atrial appendage occluder according to a third embodiment of the present invention;
(14) FIG. 13 is a perspective diagram of a left atrial appendage occluder according to a third embodiment of the present invention;
(15) FIG. 14 is a partial enlarged view of part of FIG. 13;
(16) FIG. 15 is an enlarged diagram of the tail ends of struts on a fixing frame in FIG. 13;
(17) FIG. 16 is a main view of a left atrial appendage occluder according to a fourth embodiment of the present invention;
(18) FIG. 17 is a perspective diagram of a left atrial appendage occluder according to a fourth embodiment of the present invention;
(19) FIG. 18 is a partial enlarged view of part of FIG. 17;
(20) FIG. 19 is a schematic diagram of motion directions of the tail ends of struts when a fixing frame of a left atrial appendage occluder enters a sheath canal and exits from the sheath canal according to the fourth embodiment of the present invention;
(21) FIG. 20 is a schematic diagram of the state when a fixing frame of a left atrial appendage occluder just enters a sheath canal or just exits from the sheath canal according to the fourth embodiment of the present invention;
(22) FIG. 21 is a schematic diagram of the state when most parts of the struts of a fixing frame of a left atrial appendage occluder have entered a sheath canal or exited from the sheath canal according to the fourth embodiment of the present invention;
(23) FIG. 22 is a schematic diagram of the state when the tail ends of the struts of a fixing frame of a left atrial appendage occluder are ready to enter a sheath canal or exit from the sheath canal according to the fourth embodiment of the present invention;
(24) FIG. 23 is a schematic diagram of the state when the tail ends of the struts of a left atrial appendage occluder are in a sheath canal according to the fourth embodiment of the present invention;
(25) FIG. 24 is a schematic diagram of the state when a fixing frame of a left atrial appendage occluder just enters a sheath canal or just exits from the sheath canal according to a fifth embodiment of the present invention;
(26) FIG. 25 is a schematic diagram of the state when most parts of struts of a fixing frame of a left atrial appendage occluder have entered a sheath canal or small parts of the struts are to exit from the sheath canal according to the fifth embodiment of the present invention; and
(27) FIG. 26 is a schematic diagram of the state when a U-shaped bent part close to tail ends of struts of a fixing frame of a left atrial appendage occluder is ready to enter a sheath canal or has exited from the sheath canal according to the fifth embodiment of the present invention.
IMPLEMENTATION OF THE OPTIMAL EMBODIMENTS
Optimal Embodiments
(28) To make the purposes, technical solutions and advantages of the invention understood more clearly, the invention is further described as below in details by embodiments with reference to drawings. It should be understood that the specific embodiments described herein are provided just for the purpose of explanation of the invention, but not intended to limit the invention.
(29) The invention is further described as below in details by multiple specific embodiments with reference to drawings.
First Embodiment
(30) As shown FIG. 6, FIG. 7 and FIG. 8, the left atrial appendage occluder 100 in the first embodiment of the invention comprises a closure disc 11 and a fixing frame 111 connected with the closure disc 11. The fixing frame 111 comprises a plurality of interconnected struts 121. The fixing frame 111 is in a shape as shown in FIG. 6 formed by cutting a nickel titanium tube into a plurality of interconnected struts 121, stretching via a die and then heat treating for shaping. The closure disc 11 is made into a mesh grid 10 via nickel titanium wires by weaving, and then made into a disc shape by heat treatment. Two ends of the closure disc are fixed by sleeves. Then, the sleeve at one end is welded with a connecting member 15 with threads connected with a conveyor, while the other end of the closure disc 11 is a fixed end having its sleeve connected with a connector 16 on the fixing frame 111. Inside the closure disc 11, a flow blocking membrane (PTFE or PET membrane) is sutured via medical suture lines. Refer to FIG. 7 for the top view of the closure disc 11. Although nine struts 121 are employed in the first embodiment, another number may be selected according to mechanical performance and size standard requirements, for example, six, eight, twelve, sixteen, etc. Those nine struts 121 are arrayed symmetrically in radial fashion and splayed like an umbrella from the center along the direction of the oblique axis. Then, tail ends 141 of the struts 121 are basically parallel to the central axis of the fixing frame 111 through U-shaped bending. Each of the struts 121 is divided into two branches at the bent part. Two branches of two adjacent struts 121 are connected into a whole through U-shaped bending and finally gathered onto the connector 16 of the fixing frame 111. The connector 16 is at one end which is not cut apart of the nickel titanium tube, and located at the center of the fixing frame 111 to form a central end connected with the closure disc 11. During the cutting, an anchor 131 at the tail end 141 of the strut 121 will also be provided by cutting. By using a corresponding die to shape the anchor 131, the anchor 131 points toward the tail end 141 of the strut 121. The root of the anchor 131 is located on the strut 121, while the tip of the anchor 131 thereof is expanded outward automatically. After being compressed, the anchor 131 is retracted onto the strut 121. The length of the anchor 131 is sized and configured, not only to ensure enough fixing effect, but also not to add risk due to an excessively large penetration depth in the left atrial appendage; for example, 1-2 mm of the anchor in length. Finally, the fixed end of the closure disc 11 and the connector 16 of the fixing frame 111 are welded together. The closure disc 11 has good flexibility, while the struts 121 have certain deformability, so that they may play a role in adjusting relative positions and relative distances between the closure disc 11 and the fixing frame 111 to a certain extent. Thus, the anchor 131 on the struts 121 points toward the closure disc 11 and may pin at different depths into the left atrial appendage, and the seal of the closure 11 to the entrance of the left atrial appendage is ensured.
Second Embodiment
(31) As shown in FIG. 9, FIG. 10 and FIG. 11, the left atrial appendage occluder 200 in the second embodiment of the invention comprises a closure disc 11 and a fixing frame 112 connected with the closure disc 11. The closure disc 11 is made into a mesh shape via nickel titanium wires by weaving, and then made into a disc shape by heat treatment. Two ends thereof are fixed by sleeves. The sleeve at one end is welded with a connecting member 15 with threads connected with a conveyor. Then, a flow blocking membrane (PTFE or PET membrane) is sutured inside the closure disc 11 via medical suture lines. The other end of the closure disc 11 is a fixed end. The sleeve of the fixed end is connected with a central end of the fixing frame 112. The central end comprises a flexible connector 17. The top view of the closure disc 11 is the same as shown in FIG. 7 in the first embodiment. Struts 122 of the fixing frame 112 are formed by cutting nickel titanium tubes and heat treating them for shaping. During the cutting, the anchor 132 on the fixing frame 112 will also be provided by cutting. The shape of the anchor 132 is formed by a corresponding die, and the anchor 132 points toward the tail end 142 of the strut 122. When cutting the nickel titanium tubes, the flexible connector 17 will also be formed by cutting. The flexible connector 17 comprises an elastic spiral structure which is located between the sleeve at the fixed end of the closure disc 11 and the struts 122 of the fixing frame 112. The flexible connector is as shown in FIG. 11 after partial enlargement. Finally, the sleeve at the fixed end of the closure disc 11 and the flexible connector 17 of the fixing frame 112 are connected together by welding. The flexible connector 17 has better deformability and may adjust the relative positions and relative distances between the closure disc 11 and the fixing frame 112 within a larger scope. Thus, the anchor 132 of the strut 122 points towards the closure disc 11 and can stably pin at different depths in the left atrial appendage, and the seal of the closure 11 to the entrance of the left atrial appendage is ensured.
Third Embodiment
(32) As shown in FIG. 12 to FIG. 15, the left atrial appendage occluder 300 in the third embodiment of the invention comprises a closure disc 11 and a fixing frame 113 connected with the closure disc 11. The closure disc 11 is made into a mesh shape via nickel titanium wires by weaving, and then made into a disc shape by heat treatment. Two ends thereof are fixed by sleeves. The sleeve at one end is welded with a connecting member 15 with threads connected with a conveyor. Then, a flow blocking membrane (PTFE or PET membrane) is sutured inside the closure disc 11 via medical suture lines. The other end of the closure disc 11 is a fixed end. The sleeve of the fixed end is connected with a central end of the fixing frame 113. The central end comprises a connecting spring 18. The top view of the closure disc 11 is the same as shown in FIG. 7 in the first embodiment. Struts 123 of the fixing frame 113 are shaped by cutting and heat treating nickel titanium tubes. Tail ends of the struts 123 are made into bulbs 19 by hot melting, as shown in FIG. 5, to lower the damage of the occluder to the left atrial appendage. During the cutting, the anchor 133 on the fixing frame 113 will also be provided by cutting. The shape of the anchor 133 is formed by a corresponding die, and the anchor 133 points toward the tail end 143 of the strut 123. When cutting the nickel titanium tube, a short section of the nickel titanium tube still remains at the other end of the fixing frame 113 away from the bulb 19, to avoid the separation of the struts 123 from each other at this end. The connecting spring 18 forms a spiral structure via single or multiple nickel titanium wires by heat treatment, which is as shown in FIG. 14 after partial enlargement. Finally, the closure disc 11 and the fixing frame 113 are connected together by the connecting spring 18. One end of the connecting spring 18 is welded with the sleeve at the fixed end of the closure disc 11, while the other end of the connecting spring 18 is welded with the end of the fixing frame 113 where the nickel titanium tube remains uncut. The connecting spring 18 has strong deformability and may adjust the relative positions and relative distances between the closure disc 11 and the fixing frame 113 to a large extent. Thus, the anchor 133 of the struts 123 points towards the closure disc 11 and can stably pin at different depths in the left atrial appendage, and the seal of the closure 11 to the entrance of the left atrial appendage is ensured.
Fourth Embodiment
(33) As shown in FIG. 16 to FIG. 18, the left atrial appendage occluder 400 in the fourth embodiment of the invention comprises a closure disc 11 and a fixing frame 114 connected with the closure disc 11. The closure disc 11 is made into a mesh shape via nickel titanium wires by weaving, and then made into a disc shape by heat treatment. Two ends thereof are fixed by sleeves. The sleeve at one end is welded with a connecting member 15 with threads connected with a conveyor. Then, a flow blocking membrane (PTFE or PET membrane) is sutured inside the closure disc 11 via medical suture lines. The other end of the closure disc 11 is a fixed end. The sleeve of the fixed end is connected with a central end of the fixing frame 113. The central end comprises a multi-strand flexible member 20. The top view of the closure disc 11 is the same as shown in FIG. 7 of the first embodiment. Struts 124 of the fixing frame 114 are shaped by cutting and heat treating nickel titanium tubes. Tail ends of the struts 124 are made into bulbs 194 by hot melting, as shown in FIG. 16, to lower the damage of the occluder to the left atrial appendage. During the cutting, the anchor 134 on the fixing frame 114 will also be formed by cutting. The shape of the anchor 134 is formed by a corresponding die, and the anchor 134 points toward the tail end 144 of the strut 124. When cutting the nickel titanium tube, a short section of the nickel titanium tube is still remained at the other end of the fixing frame 114 away from the bulb 194, to avoid the separation of the struts 124 from each other at this end. The multi-strand flexible member 20 is bent into drum-shaped ribs as shown in FIG. 18 via four nickel titanium wires (it may be understood that the number of nickel titanium wires may be less than or more than four; other metal wires may also be used, such as stainless steel wires; each of the nickel titanium wires may be replaced with multiple composite nickel titanium ropes) by heat treatment, because the nickel titanium wires have superelasticity so that the distance between two ends of the multi-strand flexible member 20 may be drawn away. Of course, the multi-strand flexible member 20 may be of other known linear closure structure with the same function as long as all elastic wires are gathered and fixed symmetrically at two ends of this structure, and two ends of the structure have characteristics that they can move relative to each other within a scope permitted by the elastic wires, maintain a shorter distance at the natural state, provide a stable support force and may lengthen the distance under the action of tension. Finally, the closure disc 11 and the fixing frame 114 are connected together by the multi-strand flexible member 20. One end of the multi-strand flexible member 20 is welded with the sleeve at the fixed end of the closure disc 11, while the other end of the multi-strand flexible member 20 is welded with the end of the fixing frame 114 where the nickel titanium tube remains uncut. The multi-strand flexible member 20 has strong deformability and may adjust the relative positions and relative distances between the closure disc 11 and the fixing frame 114 to a large extent. Thus, the anchor 134 of the strut 124 points towards the closure disc 11 and can stably pin at different depths in the left atrial appendage, and the seal of the closure 11 to the entrance of the left atrial appendage is ensured, as shown in FIG. 4 and FIG. 5. In other embodiments of the invention, the diagrams of positions of the left atrial appendage occluder in the anatomical structure of a heart and a left atrial appendage are similar to FIG. 4 and FIG. 5.
(34) As shown in FIG. 19 to FIG. 23, the processes of the fixing frame 114 entering a sheath canal 22 and exiting from the sheath canal 22 have the following characteristics: under the action of a connecting rod 21 of the conveyor, when the fixing frame 114 at the stretched state will retract hack in the sheath canal 22, the tail ends of the struts 124 move along direction A shown in FIG. 19, and different stages of entering the sheath canal 22 are as shown in FIG. 20, FIG. 21, FIG. 22 and FIG. 23 so that the bulbs 194 at the tail ends of each strut 124 and the anchor 134 will do an overturn; when the fixing frame 114 in the sheath canal 22 is pushed out from the sheath canal 22, the tail ends of the struts 125 move along direction B shown in FIG. 19 opposite to all stages of entering the sheath canal 22, and different stages of exiting from the sheath canal 22 will be performed in the order of FIG. 23, FIG. 22. FIG. 21 and FIG. 20; the bulbs 194 at the tail ends of each strut 124 and the anchor 134 will do an overturn opposite to that of entering the sheath canal. Such a design may make the anchor 134 penetrating in the wall of the left atrial appendage and pointing towards the entrance of the left atrial appendage, to be advantageous to avoid falling off of the fixing frame 114. When it is required to withdraw the left atrial appendage occluder 400, the anchor 134 can invert the direction and enter the sheath canal 22 smoothly without damage to the left atrial appendage. Therefore, the left atrial appendage occluder 400 in this embodiment can ensure the good repeated positioning of the fixing frame 114 in the left atrial appendage; i.e., the good repeated positioning of the whole left atrial appendage occluder is ensured. Furthermore, the left atrial appendage occluder lowers the damage of the device to the left atrial appendage and also makes the device applicable to a smaller sheath canal, to be convenient for surgical operations.
Fifth Embodiment
(35) As shown in FIG. 24 to FIG. 26, based on the third embodiment or the fourth embodiment, the difference between the fifth embodiment and the third embodiment or the fourth embodiment is the fixing frame. The fixing frame 115 in the fifth embodiment is roughly similar to the fixing frame in the third embodiment or the fourth embodiment, but the difference is that each strut 125 of the fixing frame 115 in the fifth embodiment is added with a U-shaped bent part 235, and the U-shaped bent part 235 is located between the bulb 195 at the tail end of the strut 125 and the anchor 135. In the state shown in FIG. 24, a part of the fixing frame 115 in this embodiment is retracted in the sheath canal 22, while the tail ends of the struts 125 remain outside the sheath canal 22. In this case, the anchor 135 points basically towards the closure disc 11 (retracted back in the sheath canal and slightly outwards from the axis. The U-shaped bent part 235 is bent towards the center of the fixing frame 115 near from the anchor 135, and the bulbs 195 are fixed at the tail ends of the U-shaped bent parts 235. The tail ends of the struts 125 are hard and have bad stimulation to the contact part of the left atrial appendage, so the struts 125 are added with the U-shaped bent parts 235 which allow the tail ends of the struts 125 avoid contact with the left atrial appendage, and the damage of the expanded occluder in the left atrial appendage to the left atrial appendage is reduced. When manufacturing the fixing frame 115, by using a shaping die of the fixing frame 115, one section of the strut 125 is directly processed into the U-shaped bent part 235 by heat treatment.
(36) The fixing frame 115 in this embodiment is shown as FIG. 24, FIG. 25, FIG. 26, FIG. 22 and FIG. 23 when entering or exiting the sheath canal 22 and has the following characteristics: under the action of a connecting rod 21 of the conveyor, when the fixing frame 115 at the stretched state will retract back in the sheath canal 22, the tail ends of the struts 125 move along direction C shown in FIG. 24, and different stages of entering the sheath canal 22 are in the order as shown in FIG. 24, FIG. 25, FIG. 26, FIG. 22 and FIG. 23; the bulb 195 at the tail end of each strut 125 and the anchor 135 will do an overturn, but the overturn range of the bulbs 195 at the tail ends is larger than that of the anchor 135; when the fixing frame 115 in the sheath canal 22 is pushed out from the sheath canal 22, the tail ends of the struts 125 move along direction D shown in FIG. 24 opposite to all stages of entering the sheath canal 22, and different stages of exiting from the sheath canal 22 will be performed in the order of FIG. 23, FIG. 22. FIG. 26, FIG. 25 and FIG. 24; the bulb 195 at the tail end of each strut 125 and the anchor 135 will do an overturn opposite to that of entering the sheath canal 22, the overturn range of the bulbs 195 at the tail ends is larger than that of the anchor 135. Such a design in this embodiment has many advantages. The anchor 135 on the struts 125 of the fixing frame 115 has the same structure and technical effects as those of the above embodiments, but the U-shaped bent parts 235 near the tail ends of the struts 125 can better avoid the damage of the tail ends of the struts to the left atrial appendage.
(37) The straightened state of the U-shaped bent parts 235 near the tail ends of the struts 125 of the fixing frame 115 in the fifth embodiment is the same as that in FIG. 22, and the state that the tail ends of the struts 125 are completely in the sheath canal 22 is identical to that shown in FIG. 23.
(38) In conclusion, the left atrial appendage occluder is formed by direct connection of an elastic closure disc with a membrane amounted inside it and a fixing frame containing a plurality of struts, or comprises an elastic closure disc with a membrane amounted inside it and a fixing frame connected with the closure disc by a flexible connection structure and provided with a plurality of struts. The whole structure has good stability. The anchor on the struts may turn 180° with the struts, thereby strengthening the anchoring force of the anchor and reducing the damage of the anchor to the left atrial appendage when withdrawing the occluder, also it is advantageous to the repeated positioning of the device and applicable to various structures of left atrial appendage, and the stable positioning may be realized. The tail ends of the struts may realize a 180° or 360° overturn. The bulbs at the tail ends of the struts ensure the successful positioning of the fixing frame and prevent the tail ends of the struts from penetrating through the left atrial appendage. The U-shaped bent parts near the tail ends of the struts further reduce the damage of the occluder to the left atrial appendage. The flexible connection structure may be a spiral structure or a mufti-strand structure, so that the effective adjustment of relative positions and relative distances between the closure disc and the fixing frame is ensured and positioning requirements for different depths of the left atrial appendage of various structures may be realized.
(39) Therefore, the invention has the following advantages:
(40) 1. The left atrial appendage occluder has a stable structure and can fit various structures and various sizes of the cavity of the left atrial appendage to the largest extent.
(41) 2. It can be positioned on the wall of the left atrial appendage more stably and seal the entrance of the left atrial appendage more closely, considering the balance between the positioning and sealing key effects.
(42) 3. The left atrial appendage occluder is easy to position repeatedly and may be withdrawn before being detached from a conveyor. When in surgical operation, a position area can be selected based on the actual shape and size of the patient's left atrial appendage, selection of an improper position area caused by limitations of the device can be avoided and the surgical risk is lowered.
(43) 4. The operating steps are simple and smooth, so times of repeated positioning by a doctor is reduced to the largest extent, and the damage to a patient is lowered.
(44) 5. The left atrial appendage occluder can fit a small sheath canal, and so the damage of the sheath canal to the patient's vascular wall is lowered.
(45) The above just describes optimal embodiments of the invention, but is not intended to limit the invention. Any modification, equivalent substitution and improvement made within the spirit and principle of the invention should fall into the protection scope of the invention.
