Sprayable high viscosity cosmetic formulation

Abstract

The invention relates to an anhydrous cosmetic or dermatological formulation comprising a viscose lipid-containing preparation and propellant gas consisting essentially of one or more substances selected from hydrofluorocarbons, n-butane, isobutane and propane. The formulation permits application to the skin by spraying of an otherwise nonsprayable preparation. The formulation is free from readily volatile solvents, surfactants, and preferably free from silicones.

Claims

1. A topical formulation for application to skin, wherein the formulation is sprayable and comprises an anhydrous lipid-containing preparation, and propellant gas consisting essentially of one or more substances selected from hydrofluorocarbons, n-butane, isobutane and propane, the lipid-containing preparation being in direct contact with the propellant gas and comprising ethanol, methanol, isopropanol, petroleum spirit and surfactants in concentrations of in each case from 0% to less than 0.1% by weight and a concentration of silicone compounds of from 0% to less than 40% by weight, based on a total mass of the preparation, and a concentration of the lipid-containing preparation being less than 70% by weight, based on a total mass of the formulation, and wherein upon spraying the formulation from a container, the formulation forms a cream-like mousse.

2. The formulation of claim 1, wherein the lipid-containing preparation exhibits a dynamic viscosity of from 15,000 to 30,000 mPa*s, measured at 25° C. and with a shear rate of 10 s.sup.−1.

3. The formulation of claim 1, wherein a weight ratio of lipid-containing preparation to propellant gas is from 60:40 to 40:60.

4. The formulation of claim 1, wherein the propellant gas is n-butane, alone or in combination with isobutane and/or propane.

5. The formulation of claim 4, wherein a weight ratio of n-butane to isobutane and/or propane ranges from 99.9:0.1 to 90:10.

6. The formulation of claim 1, wherein the propellant gas consists of n-butane.

7. The formulation of claim 1, wherein the formulation is free from silicone compounds.

8. The formulation of claim 1, wherein the formulation is free from film-forming substances.

9. The formulation of claim 1, wherein the lipid-containing preparation comprises Cera Microcristallina, mineral oil, ceresin, and lanolin alcohol.

10. The formulation of claim 1, wherein the lipid-containing preparation comprises at least 97% by weight of one or more lipids, based on a total weight of the lipid-containing preparation.

11. A pressurized gas container, wherein the container comprises the formulation of claim 1.

12. A topical formulation for application to skin, wherein the formulation is sprayable and comprises an anhydrous lipid-containing preparation, and propellant gas consisting essentially of one or more substances selected from hydrofluorocarbons, n-butane, isobutane and propane, the lipid-containing preparation being in direct contact with the propellant gas and comprising ethanol, methanol, isopropanol, petroleum spirit and surfactants in concentrations of in each case from 0% to less than 0.1% by weight and a concentration of silicone compounds of from 0% to less than 40% by weight, based on a total mass of the preparation, and a concentration of the lipid-containing preparation being less than 70% by weight, based on a total mass of the formulation, and wherein the formulation forms droplets having a size larger than 10 nm upon being sprayed from a can.

13. A topical formulation for application to skin, wherein the formulation is sprayable and comprises, an anhydrous lipid-containing preparation comprising at least 80% by weight of one or more lipids, based on a total weight of the lipid-containing preparation, and exhibiting a dynamic viscosity of from 15,000 to 30,000 mPa*s, measured at 25° C. and with a shear rate of 10 s.sup.−1, and propellant gas consisting essentially of one or more substances selected from n-butane, isobutane and propane, the lipid-containing preparation being in direct contact with the propellant gas and comprising ethanol, methanol, isopropanol, petroleum spirit and surfactants in concentrations of in each case from 0% to less than 0.1% by weight and a concentration of silicone compounds of from 0% to less than 40% by weight, based on a total mass of the preparation, a weight ratio of lipid-containing preparation to propellant gas being from 60:40 to 40:60.

14. The formulation of claim 13, wherein a weight ratio of lipid-containing preparation to propellant gas is from 55:45 to 45:55.

15. The formulation of claim 13, wherein the propellant gas consists of n-butane.

16. The formulation of claim 14, wherein the propellant gas consists of n-butane.

17. The formulation of claim 13, wherein the formulation is free from silicone compounds.

18. The formulation of claim 13, wherein the formulation is free from film-forming substances.

19. The formulation of claim 13, wherein the lipid-containing preparation comprises Cera Microcristallina, mineral oil, and ceresin.

20. The formulation of claim 13, wherein the lipid-containing preparation comprises at least 97% by weight of one or more lipids, based on a total weight of the lipid-containing preparation.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) In the accompanying drawings, FIGS. 1-10 are sketches of photographs which show test tubes containing mixtures of lipid-containing preparation and propellant gas in various weight ratios and with various propellant gas compositions.

DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION

(2) The particulars shown herein are by way of example and for purposes of illustrative discussion of the embodiments of the present invention only and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the present invention. In this regard, no attempt is made to show details of the present invention in more detail than is necessary for the fundamental understanding of the present invention, the description in combination with the drawings making apparent to those of skill in the art how the several forms of the present invention may be embodied in practice.

(3) The following experimental series reveal the advantages of the lipid-containing preparation with propellant gases at different mixing ratios, the results of which (photos or sketches of the photos) are shown in FIGS. 1 to 10.

(4) FIG. 1: 50% n-butane:50% viscose lipid-containing preparation

(5) The once (i.e. without propellant gas) high viscosity (24 860 mPa*s) lipid-containing preparation is present in the dissolved state at a mixing ratio of 50:50 (propellant gas: preparation). The sprayability of the formulation is ensured. This mixture is shown to be particularly preferred on account of the lowest streak formation.

(6) Streak formation here is evidence of poor discharge.

(7) FIG. 2: 50% isobutane:50% viscose lipid-containing preparation

(8) The once high viscosity lipid-containing preparation is present in the dissolved state at a mixing ratio of 50:50. A thin film of formulation is observed on the container wall. The sprayability of the formulation is nevertheless ensured.

(9) FIG. 3: 50% n-propane:50% viscose lipid-containing preparation

(10) The once high viscosity lipid-containing preparation is present in the dissolved state at a mixing ratio of 50:50. Deposits and a thin film of formulation are observed on the container wall. The sprayability of the formulation is ensured.

(11) FIG. 4: 50% propellant gas mixture (consisting of 60% n-butane, 20% isobutane, 20% n-propane):50% viscose lipid-containing preparation

(12) The once high viscosity lipid-containing preparation is present in the dissolved state at a mixing ratio of 50:50. Deposits and a thin film of preparation are observed on the container wall. The sprayability of the formulation is ensured.

(13) FIG. 5: 40% n-butane:60% viscose lipid-containing preparation

(14) The once high viscosity (18 410 mPa*s) lipid-containing preparation is present in a dissolved state at a mixing ratio of 40:60. Deposits and a thin film of formulation are observed on the container wall. The sprayability of the formulation is ensured.

(15) FIG. 6: 40% isobutane:60% viscose lipid-containing preparation

(16) The once high viscosity lipid-containing preparation is present in the dissolved state at a mixing ratio of 40:60. Deposits and a thin film of formulation are observed on the container wall. The sprayability of the formulation is ensured.

(17) FIG. 7: 40% n-propane:60% viscose lipid-containing preparation

(18) The once high viscosity lipid-containing preparation is present in the dissolved state at a mixing ratio of 40:60. Deposits and a thin film of formulation are observed on the container wall. The sprayability of the formulation is ensured.

(19) FIG. 8: 40% propellant gas mixture (consisting of 60% n-butane, 20% isobutane, 20% n-propane):60% viscose lipid-containing preparation

(20) The once high viscosity lipid-containing preparation is present in the dissolved state at a mixing ratio of 40:60. Deposits and a thin film of formulation are observed on the container wall. The sprayability of the formulation is ensured.

(21) FIG. 9: 30% n-butane:70% viscose lipid-containing preparation

(22) The once high viscosity (18 670 mPa*s) lipid-containing preparation is only partially in the dissolved state at a mixing ratio of 30:70. The sprayability of the formulation is not ensured.

(23) FIG. 10: 20% n-butane:80% viscose lipid-containing preparation

(24) The once high viscosity lipid-containing preparation is in a nondissolved state at a mixing ratio of 20:80. The sprayability of the formulation is not ensured.

(25) The experiments reveal that a fraction of lipid-containing preparation of more than 70% by weight leads to a formulation that can no longer be applied.

(26) The investigations also show that it is particularly preferred to select the ratio of propellant gas to lipid-containing preparation in the weight ratio from about 40:60 to 60:40, ideally 50:50.

(27) In the case of a lower propellant gas fraction, there is no residue-free discharge and streaks remain on the vessel wall. The comparative experiments also show that a discharge of the preparation is unsuccessful and thus the advantages of freshening/cooling/tingling as well as good spreadability are not ensured.

(28) Complete emptying, no streaks on the wall, no small drop formation and the formation of a cream capable of application is possible only with the specified propellant gases according to the invention (in particular butane, advantageously to 90% or 100%) and certain ratios of the lipid preparation to propellant gas, in particular in the region of about 50:50.

(29) This result was surprising and could not be foreseen by the person skilled in the art.

(30) The examples below illustrate the formulations according to the invention.

(31) Unless stated otherwise, the numerical data refer to weight fractions based on the total mass of the preparation.

EXAMPLES

(32) TABLE-US-00002 1 2 3 4 5 6 7 8 9 10 Vaseline 40 50 60 45 45 45 41.95 50 45 50 Ceresin 15 10 5.8 6 10 8 13 5 7 5 Lanolin alcohol 3 4 2 5 2 5 3 4 4 4 Panthenol 1.5 0.45 0.5 3 3 Glycerin 1.45 2 3 2 2 2 Bisabolol 0.5 0.5 0.5 Liquid paraffin 42 35 32 40.5 40.5 38 42 36 41.96 35.5 Licochalocone A 0.2 0.05 Polyhexanide 0.05 0.05 0.04 Clotrimazole 1 11 12 13 14 15 16 17 18 19 20 Vaseline 50 45 40 55 50 100 90 90 40 45 Ceresin 15 10 15 5 15 13 6 Lanolin alcohol 3 4 3 2 5 3 1.95 Panthenol 2 1.5 Glycerin 3 2 2 1.5 Bisabolol 0.5 0.5 Liquid paraffin 32 41 41.9 32.5 29.9 0 8 7.9 43.9 43.5 Licochalocone A 0.1 0.1 Coenzyme Q10 0.05 Octinidine 0.1 0.1 dihydrochloride

(33) Compositions 1 to 20 were admixed with propellant gases n-butane or n-butane/propane in a weight ratio of 50:50.

(34) TABLE-US-00003 21 22 Bisabolol 0.25 0.2 Microcrystalline 41.0 27.1 wax (Cera Microcristallina) Ceresin 15.0 15.0 Farnesol 0.25 0.0 Glycerin 1.0 1.0 Lanolin alcohol 3.0 3.0 Panthenol 1.0 1.0 Paraffinum 38.5 52.7 liquidum 100%  100%  Propellant gas Propane 50% 50% n-Butane 50% 50%

(35) All of the examples were found to be extraordinarily advantageous and pleasant both in sensory terms as well as in respect of ability to be applied.

(36) It is noted that the foregoing examples have been provided merely for the purpose of explanation and are in no way to be construed as limiting of the present invention. While the present invention has been described with reference to exemplary embodiments, it is understood that the words which have been used herein are words of description and illustration, rather than words of limitation. Changes may be made, within the purview of the appended claims, as presently stated and as amended, without departing from the scope and spirit of the present invention in its aspects. Although the present invention has been described herein with reference to particular means, materials and embodiments, the present invention is not intended to be limited to the particulars disclosed herein; rather, the present invention extends to all functionally equivalent structures, methods and uses, such as are within the scope of the appended claims.