COMPOUNDS HAVING A FUNGICIDAL ACTIVITY, THEIR AGRONOMIC COMPOSITIONS AND USE THEREOF FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI

Abstract

Compounds having general formula (I) with a high fungicidal activity are described, and their use for the control of phytopathogenic fungi of important agricultural crops.

Claims

1. A compound Compounds having general formula (I): ##STR00026## wherein: R.sub.c represents a formylamine group, an amino group, a nitro group a hydrogen atom, a halogen atom selected from fluorine, chlorine, bromine or iodine a C1-C12-alkyl carbonyl group, a benzoyl group, said groups being optionally substituted with one or more R.sub.d groups, the same as or different from each other; M represents a W.sup.1R.sup.6 group or a halogen atom selected from fluorine, chlorine, bromine or iodine; W and W.sup.1, the same or different, represent an oxygen atom or a sulfur atom; R.sub.d represents a hydrogen atom, a halogen atom selected from fluorine, chlorine, bromine or iodine, a nitro group, an amino group, a formylamine group, a cyano group, a C.sub.1-C.sub.18 alkyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.3-C.sub.18 cycloalkyl-C.sub.1-C.sub.12-alkyl group, C.sub.1-C.sub.18 haloalkyl group, a C.sub.2-C.sub.18 alkenyl group, a C.sub.2-C.sub.18 haloalkenyl group, a C.sub.3-C.sub.18 cycloalkenyl group, a C.sub.1-C.sub.18 alkoxyl group, a C.sub.1-C.sub.18 haloalkoxyl group, a C.sub.1-C.sub.18 thioalkoxyl group, a C.sub.1-C.sub.18 alkylsulfonyl group, a C.sub.1-C.sub.18 alkylsulfinyl group, a C.sub.3-C.sub.18 cycloalkoxyl group, an aryl group, a phenoxyl group, a benzyloxy group, an aryl-C.sub.1-C.sub.18-alkyl group, a heterocyclic group, penta- or hexa-atomic, aromatic or non-aromatic, also benzocondensed or heterobicyclic, containing at least one heteroatom selected from oxygen, sulfur, optionally oxidized to sulfoxide or to sulfone, nitrogen, optionally oxidized to N-oxide or a heterocyclyl-C.sub.1-C.sub.18-alkyl group wherein the heterocyclic group is as defined above; a C (?W.sup.1) R.sup.8 group, a C (?O)OR.sup.8 group, a C (?O) NR.sup.8 R.sup.9 group, a S (?O).sub.2NR.sup.8 R.sup.9 group; n represents a number ranging from 0 to 2; R.sup.6 represents a hydrogen atom, a CH.sub.2OR.sup.7 group, a CH.sub.2SR.sup.7 group, a COR' group, a CH.sub.2OCOR.sup.7 group; R.sup.7 represents a C.sub.1-C.sub.18 alkyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.1-C.sub.18 alkoxyl group, an aryl group, a benzyl group, said groups being optionally substituted with one or more R.sub.d groups the same as or different from each other; R.sup.8 and R.sup.9, the same or different, represent a hydrogen atom, a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.2-C.sub.18 alkenyl group, a C.sub.2-C.sub.18 haloalkenyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.3-C.sub.18 halocycloalkyl group, an aryl group, an aryl-C.sub.1-C.sub.18-alkyl group, each of said groups R.sup.8 and R.sup.9 can be optionally substituted by 0, 1 or multiples of R.sub.d; Y represents one of the following Y.sup.1 or Y.sup.2 groups ##STR00027## wherein: R.sub.a and R.sub.b, the same or different, represent a hydrogen atom, a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.3-C.sub.18 cycloalkyl group, an aryl group, an aryl-C.sub.1-C.sub.18-alkyl group, a heterocyclic group, penta- or hexa-atomic, aromatic or non-aromatic, containing at least one heteroatom selected from oxygen, sulfur, possibly oxidized to sulfoxide or sulfone, nitrogen, possibly oxidized to N-oxide, a heterocyclyl-C.sub.1-C.sub.18-alkyl group wherein the heterocyclic group is as defined above; said groups being optionally substituted with one or more R.sub.d groups, the same as or different from each other; or R.sub.a and R.sub.b together with the carbon atom to which they are bound form a C.sub.3-C.sub.18 cycloalkyl ring; R.sub.e and R.sub.f, the same or different, represent a hydrogen atom, a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, said groups being optionally substituted with one or more R.sub.d groups the same as or different from each other; R.sup.1 represents a hydrogen atom, a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.2-C.sub.18 alkenyl group, a C.sub.2-C.sub.18 haloalkenyl group, a C.sub.2-C.sub.18 alkynyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.3-C.sub.18 cycloalkenyl group, a C.sub.3-C.sub.18 cycloalkyl-C.sub.1-C.sub.18-alkyl group, an aryl group, an aryl-C.sub.1-C.sub.18-alkyl group, a heterocyclic group, penta- or hexa-atomatic, aromatic or non-aromatic, also benzocondensed or heterobicyclic, containing at least one heteroatom selected from oxygen, sulfur, possibly oxidized to sulfoxide or sulfone, nitrogen, possibly oxidized to N-oxide or a heterocyclyl-C.sub.1-C.sub.18-alkyl group wherein the heterocyclic group is as defined above; said groups being optionally substituted with one or more R.sub.d groups, the same as or different from each other; R.sup.2 represents a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.2-C.sub.18 alkenyl group, a C.sub.2-C.sub.18 haloalkenyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.3-C.sub.18 cycloalkenyl group, a C.sub.3-C.sub.18 cycloalkyl -C.sub.1-C.sub.18-alkyl group, an aryl group, an aryl-C.sub.1-C.sub.18-alkyl group, a heterocyclic group, penta- or hexa-atomatic, aromatic or non-aromatic, also benzocondensed or heterobicyclic, containing at least one heteroatom selected from oxygen, sulfur, possibly oxidized to sulfoxide or to sulfone, nitrogen, possibly oxidized to N-oxide or a heterocyclyl-C.sub.1-C.sub.18-alkyl group wherein the heterocyclic group is as defined above, a COOR.sup.2 group, a CONHR.sup.2 group, a CONR.sup.1 R.sup.2 group; said groups being optionally substituted with one or more R.sub.d groups, the same as or different from each other, or R.sup.2 represents the following T group: T= ##STR00028## wherein: R.sup.3, R.sup.5, the same or different, represent a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.1-C.sub.18 alkoxyl group, a C.sub.2-C.sub.18 alkenyl group, a C.sub.2-C.sub.18 haloalkenyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.3-C.sub.18 cycloalkoxyl group, an NHR.sup.1 group, an NR.sup.1 2 group, an aryl group, a phenoxyl group, an aryl-C.sub.1-C.sub.18-alkyl group, an aryl-C.sub.1-C.sub.18-alkoxyl group, a heterocyclic group, penta- or hexa-atomic, aromatic or non-aromatic, also benzocondensed or heterobicyclic, containing at least one heteroatom selected from oxygen, sulfur, nitrogen, wherein the sulfur atom can be possibly oxidized to sulfoxide or sulfone and the nitrogen atom possibly oxidized to N-oxide or a heterocyclyl-C.sub.1-C.sub.18-alkyl group, said groups being optionally substituted with one or more R.sub.d groups, the same as or different from each other; R.sup.4 represents a hydrogen atom, a hydroxyl, a halogen atom selected from fluorine, chlorine, bromine or iodine, a C.sub.1-C.sub.18 alkyl group, a C.sub.1-C.sub.18 haloalkyl group, a C.sub.2-C.sub.18 alkenyl group, a C.sub.2-C.sub.18 haloalkenyl group, a C.sub.3-C.sub.18 cycloalkyl group, a C.sub.1-C.sub.18 alkoxyl group; or R.sup.3 and R.sup.4 together with the carbon atom to which they are bound, form a C.sub.3-C.sub.18 cycloalkyl group or a heterocyclic group, penta- or hexa-atomic, containing at least one heteroatom selected from oxygen, sulfur, possibly oxidized to sulfoxide or sulfone, nitrogen, possibly oxidized to N-oxide, said groups being optionally substituted with one or more R.sub.d groups the same as or different from each other; or R.sup.1 and R.sup.2 together with the carbon atom to which they are bound, form a C.sub.3-C.sub.18 cycloalkyl ring; with the proviso that: when R.sub.c represents a hydrogen atom, n is equal to 0, W and W.sup.1 are both oxygen, Y represents the group Y.sup.1 wherein R.sub.a and R.sub.b, different from each other, have the meaning of hydrogen and methyl, R.sup.1 represents a methyl group, R.sup.2 is a T group wherein R.sup.4 is a hydrogen atom, R.sup.3 and R.sup.5 both represent a 4-fluorophenyl group, then R.sup.6 is different from hydrogen or is different from a CH.sub.2OCOR.sup.7 group wherein R.sup.7 is a methyl.

2. The compound according to claim 1, wherein R.sub.c represents a formylamine group; M represents an OR.sup.7 group; Y represents a Y.sup.1 group wherein R.sub.a is H and R.sub.b is (S)CH.sub.3; R.sub.d represents a hydrogen atom; W represents an oxygen atom.

3. The compound compounds according to claim 1, wherein Y has the meaning of Y.sup.1 and R.sub.d, R.sub.c, M, R.sub.1, R.sub.2, W, n, R.sub.a and R.sub.b have the meanings indicated hereunder: TABLE-US-00012 Comp. 0 R.sub.d R.sub.c W M R.sub.a R.sub.b R.sup.1 R.sup.2 1 0 NH.sub.2 O OH H H 3,3,5,5-tetramethyl-cyclohexyl 2 0 NHCHO O OH H H 3,3,5,5-tetramethyl-cyclohexyl 3 0 NHCHO O OH (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 4 0 NHCHO O OH H H 3-ethyl-3,5,5-trimethyl cyclohexyl 5 0 NHCHO O OH (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 6 0 NH.sub.2 O OH (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 7 0 NH.sub.2 O OCOOEt (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 8 0 NHCHO O OCOOEt (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 9 0 NHCHO O OCOOMe (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 10 0 NHCHO O OCOOEt (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 11 0 NHCHO O OCOOMe (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 12 0 NH.sub.2 O OCOOi-Bu CF.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 13 0 NHCHO O OCOOi-Bu CF.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 14 0 NHCHO O OCOOi-Bu 4-OCH.sub.3- H 3,3,5,5-tetramethyl-cyclohexyl phenyl 15 0 NHCHO O OCOOMe 4-OCH.sub.3- H 3,3,5,5-tetramethyl-cyclohexyl phenyl 16 0 NHCHO O OCOCH.sub.3 4-OCH.sub.3- H 3-ethyl-3,5,5-trimethyl-cyclohexyl phenyl 17 0 NH.sub.2 O OCOCH.sub.3 4-Cl- H 3-ethyl-3,5,5-trimethyl cyclohexyl phenyl 18 0 NH.sub.2 O OCOCH.sub.3 4-OCH.sub.3- H 3-ethyl-3,5,5-trimethyl cyclohexyl phenyl 19 0 NHCHO O OCOCH.sub.3 4-Cl- H 3-ethyl-3,5,5-trimethyl cyclohexyl phenyl 20 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 3,3,5,5-tetramethyl-cyclohexyl 21 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 3-ethyl-3,5,5-trimethyl cyclohexyl 22 0 NH.sub.2 O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 23 0 NHCHO O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 24 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H 3-ethyl-3,5,5-trimethyl cyclohexyl 25 0 NH.sub.2 O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 26 0 NHCHO O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 27 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H 3,3,5,5-tetramethyl-cyclohexyl 28 0 NHCHO O OCH.sub.2OCOCH.sub.3 CH.sub.3 CH.sub.3 3,3,5,5-tetramethyl-cyclohexyl 29 0 NHCHO O OCH.sub.2OCOCH.sub.3 CH.sub.3 CH.sub.3 3-ethyl-3,5,5-trimethyl cyclohexyl 30 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-hexyl 31 0 NH.sub.2 O OH (S)-CH.sub.3 H CH.sub.3 1-hexyl 32 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-hexyl 33 0 NH.sub.2 O OH H H CH.sub.3 1-octyl 34 0 NHCHO O OH H H CH.sub.3 1-octyl 35 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H methyl 36 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H methyl 37 0 NH.sub.2 O OH (S)-CH.sub.3 H borneyl 38 0 NHCHO O OH (S)-CH.sub.3 H borneyl 39 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 3-dimethyl-2-dimethyl- 1-propyl 40 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 3-dimethyl-2-dimethyl- 1-propyl 41 0 NHCHO O OH (S)-CH.sub.3 H isomenthyl 42 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H isomenthyl 43 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-adamantyl 44 0 NH.sub.2 O OCOOEt (S)-CH.sub.3 H CH.sub.3 1-heptyl 45 0 NHCHO O OCOOEt (S)-CH.sub.3 H CH.sub.3 1-heptyl 46 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-heptyl 47 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-heptyl 48 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-heptyl 49 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-heptyl 50 0 NHCHO O OCOCH.sub.3 4-OCH.sub.3- H CH.sub.3 1-heptyl phenyl 51 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-heptyl 52 0 NH.sub.2 S OH H H cyclohexyl cyclohexyl 53 0 NHCHO O OH (S)-CH.sub.3 H cyclohexyl cyclohexyl 54 0 NHCHO S OCOCH.sub.3 (S)-CH.sub.3 H cyclohexyl cyclohexyl 55 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H cyclohexyl cyclohexyl 56 0 NH.sub.2 O OH H H cyclohexyl cyclohexyl 57 0 NHCHO S OCH.sub.2OCOi-Pr (S)-CH.sub.3 H cyclohexyl cyclohexyl 58 0 NH.sub.2 S OCOCH.sub.3 CH.sub.3 CH.sub.3 cyclohexyl cyclohexyl 59 0 NHCHO S OCOCH.sub.3 CH.sub.3 CH.sub.3 cyclohexyl cyclohexyl 60 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 cyclohexyl cyclohexyl 61 0 NHCHO S OCOCH.sub.3 H H cyclohexyl phenyl 62 0 NHCHO O OCOCH.sub.3 H H cyclohexyl phenyl 63 0 NH.sub.2 O SH (S)-CH.sub.3 H cyclohexyl phenyl 64 0 NHCHO O OH (S)-CH.sub.3 H cyclohexyl phenyl 65 0 NHCHO O SH CH.sub.3 CH.sub.3 cyclohexyl phenyl 66 0 NH.sub.2 S SH H H cyclohexyl benzyl 67 0 NHCHO S SH H H cyclohexyl benzyl 68 0 NH.sub.2 O OH (S)-CH.sub.3 H 2-(4-fluorophenyl)cyclobutyl 69 0 NHCHO O OH (S)-CH.sub.3 H 2-(4-fluorophenyl)cyclobutyl 70 0 NHCHO S SH (S)-CH.sub.3 H cyclohexyl benzyl 71 0 NHCHO O OH (S)-CH.sub.3 H cyclohexyl benzyl 72 1 5-Me NH.sub.2 O OH H H H 3-cyclohexen-1-yl 73 1 5-Me NHCHO O OH H H H 3-cyclohexen-1-yl 74 1 5-Me NHCHO O OH (S)-CH.sub.3 H H 3-cyclohexen-1-yl 75 1 5-Me NH.sub.2 O OCOCH.sub.3 H H CH.sub.3 2,4-dichlorophenyl 76 1 5-Me NHCHO O OCOCH.sub.3 H H CH.sub.3 2,4-dichlorophenyl 77 1 5-Me NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 2,4-dichlorophenyl 78 1 5-Me NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 2,4-dichlorophenyl 79 1 5-t-butyl NH.sub.2 O OH H H CH.sub.3 3,5- ditrifluoromethylphenyl 80 1 5-t-butyl NHCHO O OH H H CH.sub.3 3,5- ditrifluoromethylphenyl 81 1 5-t-butyl NHCHO O OCH.sub.2OCOi-Pr H H CH.sub.3 3,5- ditrifluoromethylphenyl 82 1 5-t-butyl NHCHO O OCOCH.sub.3 H H CH.sub.3 3,5- ditrifluoromethylphenyl 83 1 5-t-butyl NHCHO O OH (S)-CH.sub.3 H CH.sub.3 3,5- ditrifluoromethylphenyl 84 1 5-t-butyl NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 3,5- ditrifluoromethylphenyl 85 1 5-t-butyl NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 3,5- ditrifluoromethylphenyl 86 1 5-t-butyl NH.sub.2 O OCOCH.sub.3 (S)-CH.sub.3 H H 1-octyl 87 1 5-t-butyl NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H H 1-octyl 88 1 5-t-butyl NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H H 1-octyl 89 1 5-t-butyl NHCHO O OCOCH.sub.3 H H 3-trifluoromethyl- 3-trifluoromethyl-phenyl phenyl 90 1 5-t-butyl NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H 3-trifluoro-methyl- 3-trifluoromethyl-phenyl phenyl 91 1 5-CH.sub.3CO NH.sub.2 O OH (S)-CH.sub.3 H 3-trifluoro- 3-trifluoromethyl-phenyl methylphenyl 92 1 5-CH.sub.3CO NHCHO O OH (S)-CH.sub.3 H 3-trifluoro-methyl- 3-trifluoromethyl-phenyl phenyl 93 1 5-CH.sub.3CO NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 94 1 5-CH.sub.3CO NHCOCH.sub.3 O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 95 1 5-CH.sub.3CO NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 96 1 5-CH.sub.3CO NH.sub.2 O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 97 1 5-CH.sub.3CO NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 98 1 5-CH.sub.3CO NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-adamantyl 99 1 5-CH.sub.3CO NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-adamantyl 100 0 NO.sub.2 O OH H H CH.sub.3 1-adamantyl 101 0 NO.sub.2 O OH (S)-CH.sub.3 H CH.sub.3 1-adamantyl 102 0 NH.sub.2 O OH (S)-CH.sub.3 H CH.sub.3 1-adamantyl 103 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-adamantyl 104 0 NHCOCH.sub.2Ph O OH (S)-CH.sub.3 H CH.sub.3 1-adamantyl 105 0 NHCOPh O OH (S)-CH.sub.3 H CH.sub.3 1-adamantyl 106 0 NO.sub.2 O OCOOi-Bu H H CH.sub.3 Dicyclohexylmethyl 107 0 NO.sub.2 O OCOOi-Bu (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 108 0 NH.sub.2 O OCOOi-Bu (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 109 0 NHCHO O OCOOi-Bu (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 110 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 111 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 112 0 NH.sub.2 O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 113 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 114 0 NHCHO O OCOOEt (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 115 0 NHCOPh O OCOOEt (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 116 1 5-Me NO.sub.2 O OH CH.sub.3 CH.sub.3 CH.sub.3 Dicyclohexylmethyl 117 1 5-Me NH.sub.2 O OH CH.sub.3 CH.sub.3 CH.sub.3 Dicyclohexylmethyl 118 1 5-Me NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 Dicyclohexylmethyl 119 0 NO.sub.2 S OH phenyl H CH.sub.3 Dicyclohexylmethyl 120 0 NH.sub.2 S OH phenyl H CH.sub.3 Dicyclohexylmethyl 121 0 NHCHO S OH phenyl H CH.sub.3 Dicyclohexylmethyl 122 0 H O OH H H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 123 0 H O OCOCH.sub.3 H H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 124 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 125 0 H O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 126 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 127 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 128 0 H O OCOOi-Bu CH.sub.3 CH.sub.3 CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 129 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 130 0 H O OCH.sub.2OCOi-Pr phenyl H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 131 0 NHCHO O OCH.sub.2OCOi-Pr phenyl H CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 132 0 H O F H H CH.sub.3 3,5-diethyl-4-heptyl 133 0 NHCHO O F H H CH.sub.3 3,5-diethyl-4-heptyl 134 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 3,5-diethyl-4-heptyl 135 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 136 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 137 1 5-F F O OH (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 138 1 5-F NHCHO O OH (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 139 1 5-Cl H O OH CH.sub.3 CH.sub.3 CH.sub.3 3,5-diethyl-4-heptyl 140 1 5-Cl NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 3,5-diethyl-4-heptyl 141 1 5-Cl H O OCOCH.sub.3 4-CH.sub.3- H CH.sub.3 3,5-diethyl-4-heptyl phenyl 142 1 5-Cl NHCHO O OCOCH.sub.3 4-CH.sub.3- H CH.sub.3 3,5-diethyl-4-heptyl phenyl 143 1 4-Cl H O OH (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 144 1 4-Cl H O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 145 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 146 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-heptyl 147 0 H O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-heptyl 148 0 NHCHO O OCH.sub.2OCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-heptyl 149 0 NHCHO O OCH.sub.2OCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 150 0 H O OCH.sub.2OCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 151 0 NH.sub.2 O OCH.sub.2OCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 152 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H H diphenylmethyl 153 0 NHCHO O OCOCH.sub.3 H H H diphenylmethyl 154 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 diphenylmethyl 155 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 diphenylmethyl 156 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 157 0 NHCHO O OCOCH.sub.3 CF.sub.3 H H diphenylmethyl 158 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H H diphenylmethyl 159 0 NHCHO O OCH.sub.2OCOi-Pr CH.sub.3 CH.sub.3 H diphenylmethyl 160 0 NHCHO O OCOOEt (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 161 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H H Bis (4-Fluoro)- phenylmethyl 162 0 NHCHO O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 163 0 NHCOPh O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 164 0 NH.sub.2 O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 165 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 166 0 NHCHO O OCH.sub.2OCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 167 0 NHCHO O OH H H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 168 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 169 0 NHCHO O OCH.sub.2OCOi-Pr H H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 170 1 5-CH.sub.3CO NHCOCH.sub.3 O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 171 0 NHCHO O OCOOi-Bu (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 172 0 OCH.sub.3 O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 173 0 F O OH CH.sub.3 CH.sub.3 (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 174 0 NHCHO O OCOCH.sub.3 CF.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 175 0 NHCHO O OCOCH.sub.3 4-Cl- H (S)-CH.sub.3 Bis (4-Fluoro)- phenyl phenylmethyl 176 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 Bis (2,4-difluoro)- phenylmethyl 177 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2,4-difluoro)- phenylmethyl 178 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2,4-difluoro)- phenylmethyl 179 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2,4-difluoro)- phenylmethyl 180 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)- phenylmethyl 181 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)- phenylmethyl 182 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)- phenylmethyl 183 0 NHCHO O OCH.sub.2OCOi-Pr CF.sub.3 H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)- phenylmethyl 184 0 NHCHO O OCOCH.sub.3 4-OCH.sub.3- H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)- phenyl phenylmethyl 185 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 Dicyclohexylmethyl 186 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Dicyclohexylmethyl 187 0 NHCHO O OCOCH.sub.3 phenyl H (S)-CH.sub.3 Dicyclohexylmethyl 188 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 1-(4-fluoro-2-methyl)- phenyl-2-methyl-1- propyl 189 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-(4-fluoro-2-methyl)- phenyl-2-methyl-1- propyl 190 0 NHCHO O OCOCH.sub.3 4-OCH.sub.3- H (S)-CH.sub.3 1-(4-fluoro-2-methyl)- phenyl phenyl-2-methyl-1- propyl 191 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 2-ethyl-1-phenyl-1-butyl 192 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 2-ethyl-1-phenyl-1-butyl 193 0 NHCHO O OCOCH.sub.3 CF.sub.3 H (S)-CH.sub.3 2-ethyl-1-phenyl-1-butyl 194 0 NHCHO O OCOCH.sub.3 4-Cl- H (S)-CH.sub.3 2-ethyl-1-phenyl-1-butyl phenyl 195 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 (4-fluoro-2-methyl)- phenyl- cyclopentylmethyl 196 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 (4-fluoro-2-methyl)- phenyl- cyclopentylmethyl 197 0 NHCHO O OCOCH.sub.3 3-F- H (S)-CH.sub.3 (4-fluoro-2-methyl)- phenyl phenyl- cyclopentylmethyl 198 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 199 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 200 0 NHCHO O OCOCH.sub.3 CF.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 201 0 NHCHO O OCOCH.sub.3 phenyl H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 202 0 NHCHO O OCOCH.sub.3 4-Cl- H (S)-CH.sub.3 1-cyclohexyl-2-methyl- phenyl 1-propyl 203 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 204 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 205 0 NHCHO O OCOOEt (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 206 0 NHCHO O OCOOi-Bu (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl- 1-propyl 207 0 NHCHO O OCOCH.sub.3 H H (S)-CH.sub.3 3,5-diethyl-4-heptyl 208 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 209 0 NHCHO O OCOCH.sub.3 CF.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 210 0 NHCHO O OCOCH.sub.3 4-CH.sub.3- H (S)-CH.sub.3 3,5-diethyl-4-heptyl phenyl 211 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 212 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 213 0 H O F (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 214 1 5-F F O OH (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 215 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 diphenylmethyl 216 0 NHCHO O OCOCH.sub.3 H diphenylmethyl 217 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 218 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 219 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-(1,3-benzothiazol-2- yl)-1-ethyl 220 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-(1,3-benzothiazol-2- yl)-1-ethyl 221 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-(1,3-benzothiazol-2- yl)-1-ethyl 222 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-(5-chloro-2H-isoindol- 2-yl)-1-ethyl 223 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-(5-chloro-2H-isoindol- 2-yl)-1-ethyl 224 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-(5-chloro- - 2H- isoindol-2-yl)-1-ethyl 225 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1,2-diphenyl-1- cyclopropyl 226 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1,2-diphenyl-1- cyclopropyl 227 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1,2-diphenyl-1- cyclopropyl 228 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-methyl-1-(4-fluoro)- phenyl)-1-ethyl 229 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-methyl-1-(4-fluoro)- phenyl)-1-ethyl 230 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-methyl-1-(4-fluoro)- phenyl)-1-ethyl 231 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-(4-chloro)-phenyl-1- cyclopentyl 232 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H CH.sub.3 1-(4-chloro)-phenyl-1- cyclopentyl 233 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-(4-chloro)-phenyl-1- cyclopentyl 234 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 235 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 236 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 237 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 2-ethyl- hexyloxycarbonyl 238 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 239 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 240 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 241 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 (S)-1-[bis-(4-fluoro)- phenyl)]-2- propoxycarbonyl 242 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 (S)-1-[bis-(4-fluoro)- phenyl)]-2- propoxycarbonyl 243 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 (S)-1-[bis-(4-fluoro)- phenyl)]-2- propoxycarbonyl 244 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 245 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 hexadecyloxycarbonyl 246 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)CH.sub.3 1-(ethoxycarbonyl)-2- methyl)-1-propyl 247 0 NHCHO O H (S)-CH.sub.3 H (S)-CH.sub.3 3,7-dimethyloct-6-en-1- yloxycarbonyl 248 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 benzyloxycarbonyl 249 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 250 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 251 0 NHCHO O OH (S)-CH.sub.3 H (R)-CH.sub.3 1-heptyl 252 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (R)-CH.sub.3 1-heptyl 253 1 5-Cl H O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 254 0 NHCHO O OCOOi-Bu (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 255 0 NHCHO O OCOOi-Bu (S)-CH.sub.3 H (S)-CH.sub.3 2-ethylhexyloxycarbonyl 256 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 257 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 258 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 diphenylmethyl 259 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Dicyclohexylmethyl 260 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-(4-fluoro-2-methyl)- phenyl-2-methyl-1- propyl 261 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-phenyl-2-ethyl-1-butyl 262 0 NHCHO O OH (S)-CH.sub.3 diphenylmethyl 263 0 NHCHO O OH H diphenylmethyl 264 0 NHCHO O OH (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 265 0 NHCHO O OH (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 266 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 benzyloxycarbonyl 267 0 NHCHO O OCOCH(CH.sub.3).sub.2 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 268 0 H O OH (S)-CH.sub.3 H CH.sub.3 1-heptyl 269 1 5-Cl H O OH (S)-CH.sub.3 H CH.sub.3 1-heptyl 270 1 5-F F O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 271 1 5-Cl H O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)- phenylmethyl 272 0 NHCHO O OH (S)-CH.sub.3 H (R)-CH.sub.3 1-hexyl 273 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 (1R,2R,5S)-5-methyl-2- (propan-2-yl)- cyclohexyloxycarbonyl 274 0 NHCHO O OCOCH.sub.3 (S)-CH H CH.sub.3 (1R,2R,5S)-5-methyl-2- (propan-2-yl)- cyclohexyloxycarbonyl 275 0 NHCHO O OH (S)-CH.sub.3 H (S)-phenyl Benzyloxycarbonyl 276 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-phenyl benzyloxycarbonyl 277 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 2-phenyl-1- (isobutoxycarbonyl)-1- ethyl 278 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 2-(4-fluoro)-phenyl-1- (isobutoxycarbonyl)-1- ethyl 279 0 NHCHO O OCOCH(CH.sub.3).sub.2 (S)-CH H (S)-CH.sub.3 2-(4-fluoro)-phenyl-1- (isobutoxycarbonyl)-1- ethyl 280 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro-4-methyl)- phenylmethyl 281 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro-4-methyl)- phenylmethyl 282 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 Bis (thiomethyl)- phenylmethyl 283 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-thiomethyl)- phenylmethyl

4. The compound compounds according to claim 1, wherein Y has the meaning of Y.sup.2 and R.sub.d, R.sub.c, M, R.sub.1, R.sub.2, W, n, R.sub.a and R.sub.b have the meanings indicated hereunder: TABLE-US-00013 Comp. n R.sub.a R.sub.c W M R.sub.e R.sub.f R.sup.1 R.sup.2 284 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-heptyl 285 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-heptyl 286 0 NHCHO S OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-heptyl 287 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 cyclohexyl cyclohexyl 288 0 NH.sub.2 O OH H H cyclohexyl cyclohexyl 289 0 NH.sub.2 S OCOCH.sub.3 CH.sub.3 CH.sub.3 cyclohexyl cyclohexyl 290 0 NHCHO S OCOCH.sub.3 CH.sub.3 CH.sub.3 cyclohexyl cyclohexyl 291 0 NHCHO S OCOCH.sub.3 H H cyclohexyl phenyl 292 0 NH.sub.2 O SH H H cyclohexyl phenyl 293 0 NHCHO O SH H H cyclohexyl phenyl 294 0 NHCHO O SH CH.sub.3 CH.sub.3 cyclohexyl phenyl 295 1 5-Me NH.sub.2 O OH H H H 3-cyclohexen-1-yl 296 1 5-Me NHCHO O OH H H H 3-cyclohexen-1-yl 297 1 5-Me NH.sub.2 O OCOCH.sub.3 H H CH.sub.3 2,4-dichlorophenyl 298 1 5-Me NHCHO O OCOCH.sub.3 H H CH.sub.3 2,4-dichlorophenyl 299 1 5-Me NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 2,4-dichlorophenyl 300 1 5-t-butyl NHCHO O OCOCH.sub.3 H H CH.sub.3 3,5-ditrifluoromethylphenyl 301 1 5-t-butyl NHCHO O OH H H CH.sub.3 3,5-ditrifluoromethylphenyl 302 1 5-t-butyl NHCHO O OCH.sub.2OCOi-Pr CH.sub.3 CH.sub.3 CH.sub.3 3,5-ditrifluoro-methylphenyl 303 1 5-t-butyl NH.sub.2 O OCOCH.sub.3 H H H 1-octyl 304 1 5-t-butyl NHCHO O OCOCH.sub.3 H H H 1-octyl 305 0 NO.sub.2 O OH H H H 1-adamantyl 306 0 NH.sub.2 O OH H H H 1-adamantyl 307 0 NHCHO O OH CH.sub.3 CH.sub.3 H 1-adamantyl 308 0 NH.sub.2 O OCOOi-Bu H H CH.sub.3 Dicyclohexylmethyl 309 0 NHCHO O OCOOi-Bu H H CH.sub.3 Dicyclohexylmethyl 310 0 NHCHO O OH H H CH.sub.3 Dicyclohexylmethyl 311 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 Dicyclohexylmethyl 312 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 Dicyclohexylmethyl 313 0 NHCHO O OCOOEt CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 314 0 NHCHO O OH CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 315 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 316 0 NHCHO O OH H H CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 317 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 318 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 319 0 NHCHO O F H H CH.sub.3 3,5-diethyl-4-heptyl 320 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 3,5-diethyl-4-heptyl 321 0 NHCHO O OH H H CH.sub.3 3,5-diethyl-4-heptyl 322 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 3,5-diethyl-4-heptyl 323 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 3,5-diethyl-4-heptyl 324 0 NHCHO O OCOCH.sub.3 H H H diphenylmethyl 325 0 NHCHO O OH H H H diphenylmethyl 326 0 NHCHO O OCH.sub.2SCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 diphenylmethyl 327 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 diphenylmethyl 328 0 NHCHO O OCH.sub.2SCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 329 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 330 0 NHCHO O OCH.sub.2OCOi-Pr H H (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 331 0 NHCHO O OH H H (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 332 0 NHCHO O OCOOEt CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 333 0 NHCHO O OCOCH.sub.3 CH.sub.3 H H Bis (4-Fluoro)-phenylmethyl 334 0 NHCHO O OH CH.sub.3 H H Bis (4-Fluoro)-phenylmethyl 335 1 5-CH.sub.3CO NHCOCH.sub.3 O OCH.sub.2SCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 336 1 5-CH.sub.3CO NHCOCH.sub.3 O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 337 0 NHCHO O OCOCH.sub.3 CF.sub.3 CF.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 338 0 NHCHO O OH CF.sub.3 CF.sub.3 (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 339 1 5-Cl NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 340 1 5-Cl NHCHO O OH H H (S)CH.sub.3 Bis (4-Fluoro)-phenylmethyl 341 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 Bis (2,4-difluoro)-phenylmethyl 342 0 NHCHO O OH H H (S)CH.sub.3 Bis (2,4-difluoro)-phenylmethyl 343 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (2,4-difluoro)-phenylmethyl 344 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 Bis (2,4-difluoro)-phenylmethyl 345 0 NHCHO O OCH.sub.2OCOi-Pr CF.sub.3 H (S)CH.sub.3 Bis (4-fluoro-2-methyl)- phenylmethyl 346 0 NHCHO O OH CF.sub.3 H (S)CH.sub.3 Bis (4-fluoro-2-methyl)- phenylmethyl 347 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 Dicyclohexylmethyl 348 0 NHCHO O OH H H (S)CH.sub.3 Dicyclohexylmethyl 349 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 Dicyclohexylmethyl 350 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 Dicyclohexylmethyl 351 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 1-(4-fluoro-2-methyl)-phenyl-2- methyl-1-propyl 352 0 NHCHO O OH H H (S)CH.sub.3 1-(4-fluoro-2-methyl)-phenyl-2- methyl-1-propyl 353 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 1-(4-fluoro-2-methyl)-phenyl-2- methyl-1-propyl 354 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 1-(4-fluoro-2-methyl)-phenyl-2- methyl-1-propyl 355 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 2-ethyl-1-phenyl-1-butyl 356 0 NHCHO O OH H H (S)CH.sub.3 2-ethyl-1-phenyl-1-butyl 357 0 NHCHO O OCH.sub.2SCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 2-ethyl-1-phenyl-1-butyl 358 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 2-ethyl-1-phenyl-1-butyl 359 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 (4-fluoro-2-methyl)-phenyl- cyclopentylmethyl 360 0 NHCHO O OH H H (S)CH.sub.3 (4-fluoro-2-methyl)-phenyl- cyclopentylmethyl 361 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 (4-fluoro-2-methyl)-phenyl- cyclopentylmethyl 362 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 (4-fluoro-2-methyl)-phenyl- cyclopentylmethyl 363 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 364 0 NHCHO O OH H H (S)CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 365 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 366 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 367 0 NHCHO O OCOCH.sub.3 CF.sub.3 H (S)CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 368 0 NHCHO O OH CF.sub.3 H (S)CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 369 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 3,5-diethyl-4-heptyl 370 0 NHCHO O OH H H (S)CH.sub.3 3,5-diethyl-4-heptyl 371 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 3,5-diethyl-4-heptyl 372 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 3,5-diethyl-4-heptyl 373 0 NHCHO O OCOCH.sub.3 CF.sub.3 H (S)CH.sub.3 3,5-diethyl-4-heptyl 374 0 NHCHO O OH CF.sub.3 H (S)CH.sub.3 3,5-diethyl-4-heptyl 375 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-(1,3-benzothiazole -2-yl)-1- ethyl 376 0 NHCHO O OCH.sub.2OCOi-Pr CH.sub.3 CH.sub.3 CH.sub.3 1-(1,3-benzothiazole -2-yl)-1- ethyl 377 0 NHCHO O OH H H CH.sub.3 1-(1,3-benzothiazole -2-yl)-1- ethyl 378 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-(5-chloro-2H-isoindol-2-yl)- 1-ethyl 379 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-(5-chloro-2H-isoindol-2-yl)- 1-ethyl 380 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 1-(5-chloro-2H-isoindol-2-yl)- 1-ethyl 381 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1,2-diphenyl-1-cyclopropyl 382 0 NHCHO O OH H H CH.sub.3 1,2-diphenyl-1-cyclopropyl 383 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1,2-diphenyl-1-cyclopropyl 384 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 1,2-diphenyl-1-cyclopropyl 385 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-methyl-1-(4-fluoro)-phenyl-1- ethyl 386 0 NHCHO O OH H H CH.sub.3 1-methyl-1-(4-fluoro)-phenyl-1- ethyl 387 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-methyl-1-(4-fluoro)-phenyl-1- ethyl 388 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 1-methyl-1-(4-fluoro)-phenyl-1- ethyl 389 0 NHCHO O OCOCH.sub.3 H H CH.sub.3 1-(4-chloro)-phenyl-1- cyclopentyl 390 0 NHCHO O OH H H CH.sub.3 1-(4-chloro)-phenyl-1- cyclopentyl 391 C NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 CH.sub.3 1-(4-clhoro)-phenyl-1- cyclopentyl 392 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 1-(4-chloro)-phenyl-1- cyclopentyl 393 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 butoxycarbonyl 394 0 NHCHO O OH H H (S)CH.sub.3 butoxycarbonyl 395 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 butoxycarbonyl 396 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 butoxycarbonyl 397 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 2-ethyl-hexyloxycarbonyl 398 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 2-ethyl-hexyloxycarbonyl 399 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 2-ethyl-hexyloxycarbonyl 400 0 NHCHO O OH H H (S)CH.sub.3 2-ethyl-hexyloxycarbonyl 401 0 NHCHO O OCOCH.sub.3 H H (S)CH.sub.3 (S)-1-[bis-(4-fluoro)-phenyl)]- 2-propoxycarbonyl 402 0 NHCHO O OH H H (S)CH.sub.3 (S)-1-[bis-(4-fluoro)-phenyl)]- 2-propoxycarbonyl 403 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 (S)-1-[bis-(4-fluoro)-phenyl)]- 2-propoxycarbonyl 404 0 NHCHO O OCOCH.sub.3 CH.sub.3 CH.sub.3 (S)CH.sub.3 (S)-1-[bis-(4-fluoro)-phenyl)]- 2-propoxycarbonyl 405 0 NHCHO O OH H H CH.sub.3 2-phenyl-1-(isobutoxycarbonyl)- 1-ethyl 406 0 NHCHO O OH CH.sub.3 CH.sub.3 CH.sub.3 2-phenyl-1- (isobutoxycarbonyl)-1-ethyl 407 0 NHCHO O OH H H (S)CH.sub.3 2-(4-fluoro)-phenyl-1- (isobutoxycarbonyl)-1-ethyl 408 0 NHCHO O OH CH.sub.3 CH.sub.3 (S)CH.sub.3 2-(4-fluoro)-phenyl-1- (isobutoxycarbonyl)-1-ethyl

5. The compound according to claim 3, wherein said compound having formula (I) is selected from compounds 30-32, 39, 40, 43-49, 51, 53-55, 57, 64, 70, 71, 74, 77, 78, 83-88, 90-93, 95-99, 103, 109-114, 126, 127, 135, 136, 138, 145, 146, 148, 149, 151, 152, 154-156, 158, 161-166, 170, 171, 177-182, 186, 189, 192, 195, 196, 199, 203-206, 208, 211, 212, 217-261, 264-267, 271, 273, 274-283,

6. The compound according to claim 4, wherein said compound having formula (I) is selected from compounds 284, 285, 287, 296-304, 307, 308, 310-312, 315-318, 320-323, 326-332, 341, 342, 347-366, 369-372, 375-408.

7. A method for controlling phytopathogenic fungi of agricultural crops comprising applying the compound of claim 1.

8. A fungicidal composition comprising the compound of claim 1, a solvent and/or solid or liquid diluent, possibly a surfactant.

9. The fungicidal composition according to claim 8, comprising at least one compound having general formula (I) and at least another fungicide different from the compounds having formula (I).

10. The fungicidal composition according to claim 9, wherein one or more compounds having general formula (I) are combined with one or more fungicides belonging to the following classes: a) azoles selected from azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, epoxyconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imazalil, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prochloraz, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triflumizole, triticonazole; b) ergosterol biosynthesis inhibitory amines selected from aldimorph, dodemorph, fenpropimorph, fenpropidin, spiroxamine, tridemorph; c) succinate-dehydrogenase inhibitors (SDHI) selected from benzovindiflupyr, bixafen, boscalid, carboxin, fluindapyr, fluopyram, flutolanil, fluxapyroxad, furametpyr, isopyrazam, oxycarboxin, penflufen, penthiopyrad, sedaxane, thifluzamide,:, d) strobilurins selected from azoxystrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraoxostrobin, trifloxystrobin; e) specific antioidic compounds selected from cyflufenamid, flutianil, metrafenone, proquinazid, pyriofenone, quinoxyfen; f) aniline-pyramidines selected from pyrimethanil, mepanipyrim, cyprodinil; g) benzimidazoles and analogues thereof selected from carbendazim, benomyl, thiabendazole, thiophanate-methyl; h) dicarboxyimides selected from iprodione, procymidone; i) phthalimides selected from captafol, captan, folpet;

l) systemic acquired resistance (SAR) inducers selected from acibenzolar, probenazole, isotianil, tiadinil; m) phenylpyrroles selected from fenpiclonil, fludioxonil; n) acylalanines selected from benalaxyl, benalaxyl-M, furalaxyl, metalaxyl, metalaxyl-M; o) other specific antiperonosporic compounds selected from ametoctradin, amisulbrom, benthiavalicarb, cyazofamid, cymoxanil, dimethomorph, ethaboxam, famoxadone, fenamidone, flumetover, flumorph, fluopicolide, iprovalicarb, mandipropamid, oxathiapiproline, valifenalate, zoxamide: p) dithiocarbamates selected from maneb, mancozeb, propineb, zineb, metiram; q) phosphorous acid and its inorganic or organic salts, fosetyl-aluminium; r) cupric compounds selected from Bordeaux mixture, carpropamid, copper hydroxide, copper oxychloride, copper sulfate, copper salicylate; and/or s) other fungicides selected from chlorothalonil, fenhexamid, fenpyrazamine, fluazinam, silthiofam, tebufloquin, zoxamide, dodine, guazatine, iminoctadine, tolclofos-methyl.

11. The fungicidal composition according to claim 8, wherein the compound having formula (I) is compound 46, 156, 165 or 249, said compositions being selected from: C1: compound 46+tetraconazole; C2: compound 46+tebuconazole; C3: compound 46+epoxyconazole; C4: compound 46+prothioconazole; C5: compound 46+difenoconazole; C6: compound 46+penconazole; C7: compound 46+prochloraz; C8: compound 46+fenpropimorph; C9: compound 46+spiroxamine; C10: compound 46+bixafen; C11: compound 46+boscalid; C12: compound 46+carboxin; C13: compound 46+fluopyram; C14: compound 46+fluxapyroxad; C15: compound 46+isopyrazam; C16: compound 46+penthiopyrad; C17: compound 46+sedaxane; C18: compound 46+azoxystrobin; C19: compound 46+dimoxystrobin; C20: compound 46+fluoxastrobin; C21: compound 46+kresoxim-methyl; C22 compound 46+picoxystrobin; C23: compound 46+pyraclostrobin; C24: compound 46+trifloxystrobin; C25: compound 46+metrafenone; C26: compound 46+proquinazid; C27: compound 46+mepanipyrim; C28: compound 46+cyprodinil; C29: compound 46+iprodione; C30: compound 46+procymidone; C31: compound 46+carbendazim; C32: compound 46+thiophanate-methyl; C33: compound 46+fluindapyr; C34: compound 46+benalaxyl-M; C35: compound 46+fenpyrazamine; C36: compound 46+fluazinam; C37: compound 46+tolclofos-methyl; C38: compound 46+mandipropamid; C39: compound 46+copper oxychloride; C40: compound 46+copper salicylate; C41: compound 46+chlorothalonil; C42: compound 46+cimoxanil; C43: compound 46+dimetomorph; C44: compound 46+oxathiopiproline; C45: compound 46+fluopicolide; C46: compound 156+tetraconazole; C47: compound 156+tebuconazole; C48: compound 156+epoxyconazole; C49: compound 156+prothioconazole; C50: compound 156+difenconazole; C51: compound 156+penconazole; C52: compound 156+prochloraz; C53: compound 156+fenpropimorph; C54: compound 156+spiroxamine; C55: compound 156+bixafen; C56: compound 156+boscalid; C57: compound 156+carboxin; C58: compound 156+fluopyram; C59: compound 156+fluxapyroxad; C60: compound 156+isopyrazam; C61: compound 156+penthiopyrad; C62: compound 156+sedaxane; C63: compound 156+azoxystrobin; C64: compound 156+dimoxystrobin; C65: compound 156+fluoxastrobin; C66: compound 156+kresoxim-methyl; C67: compound 156+picoxystrobin; C68: compound 156+pyraclostrobin; C69: compound 156+trifloxystrobin; C70: compound 156+metrafenone; C71: compound 156+proquinazid; C72: compound 156+mepanipyrim; C73: compound 156+cyprodinil; C74: compound 156+iprodione; C75: compound 156+procymidone; C76: compound 156+carbendazim; C77: compound 156+thiophanate-methyl; C78: compound 156+fluindapyr; C79: compound 156+benalaxyl-M; C80: compound 156+fenpyrazamine; C81: compound 156+fluazinam; C82: compound 156+tolclofos-methyl; C83: compound 156+mandipropamid; C84: compound 156+copper oxychloride; C85: compound 156+copper salicylate; C86: compound 156+chlorothalonil; C87: compound 156+cimoxanil; C88: compound 156+dimetomorph; C89: compound 156+oxathiopiproline; C90: compound 156+fluopicolide; C91: compound 156+zoxamide; C92: compound 156+ametoctradin; C93: compound 156+metiram; C94: compound 156+potassium phosphite; C95 compound 165+tetraconazole; C96: compound 165+tebuconazole; C97: compound 165+epoxyconazole; C98: compound 165+prothioconazole; C99: compound 165+difenoconazole; C100: compound 165+penconazole; C101: compound 165+prochloraz; C102: compound 165+fenpropimorph; C103: compound 165+spiroxamine; C104: compound 165+bixafen; C105: compound 165+boscalid; C106: compound 165+carboxin; C107: compound 165+fluopyram; C108: compound 165+fluxapyroxad; C109: compound 165+isopyrazam; C110: compound 165+penthiopyrad; C111: compound 165+sedaxane; C112: compound 165+azoxystrobin; C113: compound 165+dimoxystrobin; C114: compound 165+fluoxastrobin; C115: compound 165+kresoxim-methyl; C116: compound 165+picoxystrobin; C117: compound 165+pyraclostrobin; C118: compound 165+trifloxystrobin; C119: compound 165+metrafenone; C120: compound 165+proquinazid; C121: compound 165+mepanipyrim; C122: compound 165+cyprodinil; C123: compound 165+iprodione; C124: compound 165+procymidone; C125: compound 165+carbendazim; C126: compound 165+thiophanate-methyl; C127: compound 165+fluindapyr; C128: compound 165+benalaxyl-M; C129: compound 165+fenpyrazamine; C130: compound 165+fluazinam; C131: compound 165+tolclofos-methyl; C132: compound 165+mandipropamid; C133: compound 165+copper oxychloride; C134: compound 165+copper salicylate; C135: compound 165+chlorothalonil; C136: compound 165+cimoxanil; C137: compound 165+dimetomorph; C138: compound 165+oxathiopiproline; C139: compound 165+fluopicolide; C140: compound 249+tetraconazole; C141: compound 249+tebuconazole; C142: compound 249+epoxyconazole; C143: compound 249+prothioconazole; C144: compound 249+difenconazole; C145: compound 249+penconazole; C146: compound 249+prochloraz; C147: compound 249+fenpropimorph; C148: compound 249+spiroxamine; C149: compound 249+bixafen; C150: compound 249+boscalid; C151: compound 249+carboxin; C152: compound 249+fluopyram; C153: compound 249+fluxapyroxad; C154: compound 249+isopyrazam; C155: compound 249+penthiopyrad; C156: compound 249+sedaxane; C157: compound 249+azoxystrobin; C158: compound 249+dimoxystrobin; C159: compound 249+fluoxastrobin; C160: compound 249+kresoxim-methyl; C161: compound 249+picoxystrobin; C162: compound 249+pyraclostrobin; C163: compound 249+trifloxystrobin; C164: compound 249+metrafenone; C165: compound 249+proquinazid; C166: compound 249+mepanipyrim; C167: compound 249+cyprodinil; C168: compound 249+iprodione; C169: compound 249+procymidone; C170: compound 249+carbendazim; C171: compound 249+thiophanate-methyl; C172: compound 249+fluindapyr; C173: compound 249+benalaxyl-M; C174: compound 249+fenpyrazamine; C175: compound 249+fluazinam; C176: compound 249+tolclofos-methyl; C177: compound 249+mandipropamid; C178: compound 249+copper oxychloride; C179: compound 249+copper salicylate; C180: compound 249+chlorothalonil; C181: compound 249+cimoxanil; C182: compound 249+dimetomorph; C183: compound 249+oxathiopiproline; C184: compound 249+fluopicolide; C185: compound 46+tetraconazole+azoxystrobin, C186: compound 46+pyraclostrobin+tetraconazole; C187: compound 46+epoxyconazole+azoxystrobin; C188: compound 46+pyraclostrobin+epoxyconazole; C189: compound 46+azoxystrobin+fluindapyr; C190: compound 46+pyraclostrobin+fluindapyr; C191: compound 46+fosetyl-aluminium+copper oxychloride; C192: compound 46+fosetyl-aluminium+copper salicylate; C193: compound 46+fluindapyr+tetraconazole; C194: compound 46+tetraconazole+azoxystrobin; C195: compound 46+pyraclostrobin+tetraconazole; C196: compound 46+azoxystrobin+fluindapyr; C197: compound 46+fluindapyr+tetraconazole; C198: compound 165+tetraconazole+azoxystrobin, C199: compound 165+pyraclostrobin+tetraconazole; C200: compound 165+epoxyconazole+azoxystrobin; C201: compound 165+pyraclostrobin+epoxyconazole; C202: compound 165+azoxystrobin+fluindapyr; C203: compound 165+pyraclostrobin+fluindapyr; C204: compound 165+fosetyl-aluminium+copper oxychloride; C205: compound 165+fosetyl-aluminium+copper salicylate; C206: compound 165+fluindapyr+tetraconazole; C207: compound 165+tetraconazole+azoxystrobin; C208: compound 165+pyraclostrobin+tetraconazole; C209: compound 165+azoxystrobin+fluindapyr; C210: compound 165+fluindapyr+tetraconazole.

12. A method of controlling Use of the compositions according to any of the claims from 8 to 11, for the control of phytopathogenic fungi in agricultural crops comprising applying the composition of claim 8.

13. A method for controlling phytopathogenic fungi in agricultural crops, comprising applying an effective and non-phytotoxic dose of the compound of claim 1 on any part of the crops to be protected or on the ground and, optionally, one or more known active ingredients compatible therewith.

14. A method for controlling phytopathogenic fungi in agricultural crops, comprising applying an effective and non-phytotoxic dose of the composition of claim 8 and, optionally, one or more known active ingredients compatible therewith.

Description

EXAMPLE 1

Preparation of (2S) -2-(tert-butoxycarbonylamino)nonan-2-yl propanoate

[0343] 0.95 g of (2S)-2-(tert-butoxycarbonylamino)propanoic acid (5.0 mmoles), 0.06 g of dimethylaminopyridine (0.5 mmoles) and 1.9 g of EDCI (9.8 mmoles) [N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride] were added at 0? C. to a solution of 0.85 g of nonan-2-ol (6.0 mmoles) in 22 ml of CH.sub.2Cl.sub.2. The reaction mixture was stirred at 0? C. for 1 hour, then allowed to rise to environmental values, for 36 hours. After GC-MS control, the reaction was concentrated in a rotavapor obtaining 1.97 g of a raw product which was purified by elution with an 8/2 mixture of heptane/ethyl acetate on a thin layer of silica gel. 1.28 g of the desired product were obtained. Yield 81%

GC-MS: M.SUP.+.=315

EXAMPLE 2

Preparation of (2S)-2-aminopropanoate of nonan-2-yl hydrochloride

[0344] 10.1 ml of a 4N solution of H [0345] C1 in dioxane (41 mmoles) were added to a solution of 1.28 g of (2S)-2-(tert-butoxycarbonylamino)nonan-2-yl propanoate (4.1 mmoles) in 20 ml of CH.sub.2Cl.sub.2. The solution was stirred at room temperature for 1.5 hours. After TLC control (eluent: hexane/ethyl acetate 8/2), the reaction mixture was concentrated in a rotavapor, obtaining 1.03 g of the desired product. Yield 100%

GC-MS: M.SUP.+.=251.5

EXAMPLE 3

Preparation of (2S)-2-(3-formamide-salicylamide)-propanoate of nonan-2-yl (Compound Nr. 46)

[0346] 2.17 ml (13.13 mmoles) of diisopropylethylamine and 2.07 g (3.98 mmoles) of PyBOP [(1-Benzotriazolyloxy) tripyrrolidinephosphonium hexafluorophosphate] were added at room temperature to a suspension of 0.720 g of 3-formylamino-salicylic acid (3.98 mmoles) and 1.0 g of (2S)-2-aminopropanoate of nonan-2-yl hydrochloride (3.98 mmoles) in 35 ml of CH.sub.2Cl.sub.2. The reaction mixture was stirred at this temperature overnight. After LC-MS control, the reaction mixture was washed with water and the phases were separated. The aqueous phase was extracted with CH.sub.2Cl.sub.2(3?30 ml) and the combined organic phases were washed with a 10% hydrochloric acid solution (40 ml) and with a saturated NaCl solution (1?45 ml ). These were then dried over Na.sub.2SO.sub.4, filtered and concentrated, obtaining 3.29 g of a raw product that was washed with ethyl ether and filtered to eliminate the by-products of the condensing agent. The ether phase was concentrated in a rotavapor and then purified by silica gel chromatography by means of an automatic Biotage separator eluting with a 6/4 mixture of heptane/ethyl acetate. 0.85 g of the desired product were obtained. Yield 56%

LC-MS: M.SUP.+.=378

EXAMPLE 4

Preparation of (2S)-1,1-bis (4-fluorophenyl)propane-1,2-diol

[0347] A solution of 0.36 g of (S)-ethyl lactate (3.0 mmoles) in 15 ml of THF was added dropwise to 9.9 ml of a 1M solution of (4-fluorophenyl)magnesium bromide in THF (9.9 mmoles) cooled to 0? C. The reaction mixture was left under stirring at 0? C. until completed and then treated with a saturated solution of ammonium chloride (15 ml). The mixture was left under stirring until it had reached room temperature and then filtered to recover the solid in suspension. The solid was suspended in ethyl acetate, filtered and rinsed again with ethyl acetate. The combined organic phases were concentrated in a rotavapor, washed with water and dried with anhydrous Na.sub.2SO.sub.4. After filtering and removal of the solvent, the raw product thus obtained was purified by silica gel chromatography by means of an automatic Biotage separator, obtaining 0.54 g of the desired product. Yield 68%

LC-MS: M.SUP.+.=264

EXAMPLE 5

Preparation of (2S)-1,1-bis(4-fluorophenyl)propan-2-ol

[0348] 3.0 ml of triethylsilane (18.9 mmoles) and 1.4 ml of trifluoroacetic acid (18.9 mmoles) were added at 0? C. to a solution of 0.50 g of (2S)-1.1-bis(4-fluorophenyl) propane-1,2-diol (1.89 mmoles) in 20 ml of CH.sub.2Cl.sub.2. The reaction mixture was stirred for 1 hour at this temperature. After 1 hour it was neutralized with a 4N solution of NaOH up to pH=10, the two phases were separated and the aqueous phase was extracted with CH.sub.2Cl.sub.2 (3?20 ml). The combined organic phases were dried with anhydrous Na.sub.2SO.sub.4, filtered and concentrated in a rotavapor. The raw product obtained was purified by silica gel chromatography by means of an automatic Biotage separator eluting with a heptane/ethyl acetate gradient and obtaining 0.39 g of product. Yield 83%

LC-MS: M.SUP.+.=248

EXAMPLE 6

Preparation of (2S)-2-(3-nitrosalicylamide)ethyl propanoate

[0349] 2.26 g of N-ethylmorpholine (19.6 mmoles), 1.32 g of 1-hydroxybenzotriazole (9.8 mmoles) and 2.02 g of DCC (9.8 mmoles) [N,N-dicyclohexylcarbodiimide] were added to a solution of 1.63 g of 3-nitrosalicylic acid (8.9 mmoles) and 1.37 g of (2S)-2-aminopropanoate of ethyl hydrochloride (8.9 mmoles) in a 3/1 mixture. of CH.sub.2Cl.sub.2/HF (40 ml). The reaction mixture was stirred at room temperature for 30 minutes. After GC-MS control, the reaction was filtered to remove the insoluble by-products deriving from the condensing agent and concentrated in a rotavapor. The residue was dissolved in CH.sub.2Cl.sub.2, treated with a saturated solution of NaHCO 3 (40 ml) and the aqueous phase extracted with CH.sub.2Cl.sub.2 (3?35 ml). The combined organic phases were washed with water (1?80 ml) and a saturated solution of NaCl (1?80 ml), dried with anhydrous Na.sub.2SO.sub.4, filtered and concentrated in a rotavapor. The raw product obtained was purified by silica gel chromatography by means of an automatic Biotage separator, obtaining 1.78 g of the desired product. Yield 71%

LC-MS: M.SUP.+.=282

EXAMPLE 7

Preparation of (2S)-2-(3-nitrosalicylamide)propanoic acid

[0350] 12 ml of a 3% aqueous solution of NaOH were added to a solution of 0.99 g of (2S)-2-(3-nitrosalicylamide) ethyl propanoate (3.5 mmoles) in 15 ml of ethanol. The reaction mixture was left under stirring at 45? C. for 1 hour. After GC-MS control, the mixture was brought to acid pH with the addition of H [0351] C1, extracted with ethyl acetate (2?20 ml), and the combined organic phases were washed with a saturated solution of NaCl (1?30 ml), anhydrified, filtered and concentrated, obtaining 0.89 g of the desired product. Yield 100%

GC-MS: M.SUP.+.=254

EXAMPLE 8

Preparation of (2S)-2-(3-nitrosalicylamide)propanoate of (2S)-1,1-bis(4-fluorophenyl)propan-2-yl

[0352] 0.24 g of dimethylaminopyridine (2.0 mmoles) and 0.97 g of (2S)-1.1-bis(4-fluorophenyl) propan-2-ol (3.9 mmoles) were added to a solution of 0.99 g (2S)-2-(3-nitrosalicylamide)propanoic acid (3.9 mmoles) in THF. The solution was cooled to 0? C. and 0.97 g of DCC (4.7 mmoles) [N,N*-dicyclohexylcarbodiimide] was added at this temperature. The reaction was left under stirring at room temperature overnight. After GC-MS control, the reaction mixture was filtered to remove the by-products of the condensing agent and concentrated, obtaining 2.4 g of raw product which were purified by silica gel chromatography by means of an automatic Biotage separator. 1.21 g of the desired product were obtained. Yield 64%

GC-MS: M.SUP.+.=484

EXAMPLE 9

Preparation of (2S)-2-(3-aminosalicylamide)propanoate of (2S)-1,1-bis(4-fluorophenyl) propan-2-yl

[0353] 0.12 g of Pd/C (20% w/w) were added to a solution of 0.62 g of (2S)-2-(3-nitrosalicylamide) propanoate of (2S)-1.1-bis(4-fluorophenyl)propan-2-yl (1.3 mmoles) in 25 ml of CH.sub.3OH. The reaction environment was then saturated with an H.sub.2 atmosphere and the solution left under stirring at room temperature overnight. After LC-MS control, the reaction mixture was filtered to remove the catalyst and the concentrated filtrate in a rotavapor, obtaining 0.59 g of the desired product.

Yield 100%

LC-MS: M.SUP.+.=454

EXAMPLE 10

Preparation of (2S)-2-(3-formamide-salicylamide) propanoate of (2S)-1,1-bis(4-fluorophenyl) propan-2-yl (Compound Nr.165)

[0354] 0.024 g of zinc oxide (0.3 mmoles) were added to a solution of 1.45 g of (2S)-2-(3-aminosalicylamide)propanoate of (2S)-1.1-bis(4-fluorophenyl)propan-2-yl (3.2 mmoles) in 0.9 ml of formic acid (24.6 mmoles). The reaction mixture was then heated to 70? C. for 1 hour. After LC-MS control, the reaction mixture was washed with water and the phases separated. The aqueous phase was extracted with ethyl acetate (3?20 ml) and the combined organic phases were washed with water (2?15 ml) and with a saturated solution of NaCl (1?15 ml). These were then dried with anhydrous Na.sub.2SO.sub.4, filtered and concentrated, obtaining 0.89 g of the desired product. Yield 58%

LC-MS: M.SUP.+.=482

EXAMPLE 11

Preparation of (2S)-2-[3-formamide-2-(methoxy-(2-methyl)propanoate)-benzamide] of (2S)-1,1-bis(4-fluorophenyl)propan-2-yl (Compound Nr. 156)

[0355] 0.20 g of chloromethyl isobutyrate (1.5 mmoles), 0.03 g of sodium iodide (0.2 mmoles) and 0.21 g of Na.sub.2CO.sub.3 (2.0 mmoles) were added to a solution of 0.48 g of (25)-2-(3-formamide-salicylamide)(2S)-1,1-bis(4-fluorophenyl)propan-2-yl (1.0 mmole) in 20 ml of acetone. The reaction mixture was heated to 50? C. for 8 hours and allowed to react at room temperature overnight. After LC-MS control, the solvent was evaporated, then diluted with water and extracted with ethyl acetate (3?20 ml). The organic phases were dried with anhydrous Na.sub.2SO.sub.4, filtered and concentrated. The raw product thus obtained was purified by silica gel chromatography by means of an automatic Biotage separator, obtaining 0.37 g of product. Yield 64%

GC-MS: M.SUP.+.=582

EXAMPLE 12

Preparation of dicyclohexylmethanol

[0356] 0.60 g of sodium-boron hydride (15 mmoles) were added, at 0? C. and in portions, to a solution of 5.0 g of dicyclohexylketone (26 mmoles) in 25 ml of CH.sub.3OH. The reaction was left under stirring at room temperature overnight. After GC-MS control, the reaction was treated with an aqueous solution of 1.5 ml of glacial acetic acid (26 mmoles) and extracted with ethyl acetate (2 x 25 ml). The combined organic phases were washed with water (1?40 ml), dried with anhydrous Na.sub.2SO.sub.4, filtered and concentrated, obtaining 4.9 g of product. Yield 96%

GC-MS: M.SUP.+.=196

EXAMPLE 13

Preparation of (2S)-2-(tert-butoxycarbonylamino) dicyclohexylmethyl propinate

[0357] 5.7 g of (2S)-2-(tert-butoxycarbonylamino) propanoic acid (30 mmoles), 0.3 g of dimethylaminopyridine (2.5 mmoles) and 9.6 g of EDCI (50 mmoles) [N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride] were added, at 0? C., to a solution of 4.9 g of dicyclohexylmethanol (25 mmoles) in 112 ml of CH.sub.2Cl.sub.2. The reaction was left under stirring at 0? C. for 1 hour and then reacted at room temperature overnight. After control, the reaction was concentrated and purified by silica gel chromatography using an automatic Biotage separator, obtaining 5.41 g of the desired product. Yield 59%

GC-MS: M.SUP.+.=367

EXAMPLE 14

Preparation of (2S)-2-aminopropionate of dicyclohexylmethyl trifluoroacetate

[0358] 10.1 ml of trifluoroacetic acid (131 mmoles) were added to a solution of 4.8 g of (2S)-2-(tert-butoxycarbonylamino) dicyclohexylmethyl propionate (13.1 mmoles) in 30 ml of CH.sub.2Cl.sub.2 and the mixture was left under stirring at room temperature for 1 hour. After GC-MS control, the solvent was removed by evaporation, obtaining 3.79 g of the desired product. Yield 76%

GC-MS: M.SUP.+.=381

EXAMPLE 15

Preparation of 2-(3-formamide-salicylamide) of dicyclohexylmethyl propionate (Compound Nr. 53)

[0359] 1.6 ml (9.0 mmoles) of diisopropylethylamine and 1.4 g (2.8 mmoles) of PyBOP [(1-Benzotriazolyloxy) tripyrrolidinephosphonium hexafluorophosphate] were added, at 0? C., to a solution of 0.50 g of 3-formamide-salicylic acid (2.8 mmoles) and 1.07 g of (2S)-2-aminopropionate of dicyclohexylmethyl trifluoroacetate (2.8 mmoles) in 20 ml of CH.sub.2Cl.sub.2. The reaction mixture was stirred at this temperature for 2 hours and then allowed to rise to environmental values and under stirring for another 2 hours. After LC-MS control, the reaction mixture was washed with water and the phases separated. The aqueous phase was extracted with CH.sub.2Cl.sub.2 (3?20 ml) and the combined organic phase were washed with water (2?35 ml) and with a saturated solution of NaCl (1?35 ml), dried over anhydrous Na.sub.2SO.sub.4, filtered and evaporated, obtaining 1.8 g of a raw product which was washed with ethyl ether and filtered to eliminate the by-products of the condensing agent. The ether phase was concentrated in a rotavapor and then purified by silica gel chromatography by means of an automatic Biotage separator, obtaining 0.76 g of the desired product. Yield 63%

LC-MS: M.SUP.+.=430

EXAMPLE 16

Preparation of Compounds Nr. 47, 55, 110, 126, 135, 154, 155, 162, 166, 171, 179, 181, 182, 195, 199, 204, 208, 212, 219, 221, 222, 224, 227, 228, 230, 234, 236, 237, 239, 240, 243, 244, 245, 246, 247, 248, 249, 250, 253, 256, 257, 258, 260, 261, 264, 266, 271, 273, 275, 277, 278, 279, 280, 281, 282, 283

[0360] Operating analogously to what is indicated in the previous examples, the following compounds were obtained 47, 55, 110, 126, 135, 154, 155, 162, 166, 171, 179, 181, 182, 195, 199, 204, 208, 212, 219, 221, 222, 224, 227, 228, 230, 234, 236, 237, 239, 240, 243, 244, 245, 246, 247, 248, 249, 250, 253, 256, 257, 258, 260, 261, 264, 266, 271, 273, 275, 277, 278, 279, 280, 281, 282, 283.

[0361] having formula (I) indicated in Table 6.

TABLE-US-00006 TABLE 6 Comp. N R.sub.d R.sub.c W M R.sub.a R.sub.b R.sup.1 R.sup.2 47 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-heptyl 55 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H cyclohexyl cyclohexyl 110 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 126 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 135 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 154 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 diphenylmethyl 155 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 diphenylmethyl 162 0 NHCHO O OCH.sub.2OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 166 0 NHCHO O OCH.sub.2OCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 171 0 NHCHO O OCOOi-Bu (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 179 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2,4-difluoro)-phenylmethyl 181 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)-phenylmethyl 182 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-fluoro-2-methyl)-phenylmethyl 195 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 4-fluoro-2-methyl)-phenyl- cyclopentylmethyl 199 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 204 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-cyclohexyl-2-methyl-1-propyl 208 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 212 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 3,5-diethyl-4-heptyl 219 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-(1,3-benzothiazol-2-yl)-1-ethyl 221 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-(1,3-benzothiazol-2-yl)-1-ethyl 222 0 NHCHO O OCH.sub.2SCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-(5-chloro-2H-isoindol-2-yl)-1-ethyl 224 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-(5-chloro-2H-isoindol-2-yl)-1-ethyl 227 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1,2-diphenyl-1-cyclopropyl 228 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H CH.sub.3 1-methyl-1-(4-fluoro)-phenyl)-1-ethyl 230 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 1-methyl-1-(4-fluoro)-phenyl)-1-ethyl 234 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 236 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 butoxycarbonyl 237 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 2-ethyl-hexyloxycarbonyl 239 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 2-ethyl-hexyloxycarbonyl 240 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 benzyloxycarbonyl 243 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 (S)-1-[bis-(4-fluoro)-phenyl)]-2- propoxycarbonyl 244 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.2CH.sub.2SCH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 245 0 NHCHO O OH (S)-CH.sub.2CH.sub.2SCH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 246 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.2SCH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 247 0 NHCHO O OH (S)-CH.sub.2SCH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 248 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 benzyloxycarbonyl 249 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 250 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 1-heptyl 253 1 5-Cl H O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 Bis (2-fluoro)-phenylmethyl 256 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 Dicyclohexylmethyl 257 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 3,5-diethyl-4-heptyl 258 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 diphenylmethyl 260 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-(4-fluoro-2-methyl)-phenyl- 2-methyl-1-propyl 261 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 1-phenyl-2-ethyl-1-butyl 264 0 NHCHO O OH [00025] (S)-CH.sub.3 Bis (4-Fluoro)-phenylmethyl 266 0 NHCHO O OCOCH.sub.3 (S)-CH.sub.3 H (S)-CH.sub.3 benzyloxycarbonyl 271 1 5-Cl H O OH (S)-CH.sub.3 H (S)-CH.sub.3 Bis (4-Fluoro)-phenylmethyl 273 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 (1R,2R,5S)-5-methyl-2-(propan-2-yl)- cyclohexyloxycarbonyl 275 0 NHCHO O OH (S)-CH.sub.3 H (S)-phenyl benzyloxycarbonyl 277 0 NHCHO O OH (S)-CH.sub.3 H CH.sub.3 2-phenyl-1-(isobutoxycarbonyl)-1-ethyl 278 0 NHCHO O OH (S)-CH.sub.3 H (S)-CH.sub.3 2-(4-fluoro)-phenyl-1- (isobutoxycarbonyl)-1-ethyl 279 0 NHCHO O OCOCH(CH.sub.3).sub.2 (S)-CH3 H (S)-CH3 2-(4-fluoro)-phenyl-1- (isobutoxycarbonyl)-1-ethyl 280 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH3 H (S)-CH3 Bis (2-fluoro-4-methyl)-phenylmethyl 281 0 NHCHO O OH (S)-CH3 H (S)-CH3 Bis (2-fluoro-4-methyl)-phenylmethyl 282 0 NHCHO O OCH.sub.2OCOi-Pr (S)-CH3 H (S)-CH3 Bis (thiomethyl)-phenylmethyl 283 0 NHCHO O OH (S)-CH3 H (S)-CH3 Bis (4-thiomethyl)-phenylmethyl

[0362] Table 7 indicates the results of the GC-MS analyses carried out on compounds 47, 55, 110, 126, 135, 154, 155, 162, 166, 171, 179, 181, 182, 195, 199, 204, 208, 212, 219, 221, 222, 224, 227, 228, 230, 234, 236, 237, 239, 240, 243, 244, 245, 246, 247, 248, 249, 250, 253, 256, 257, 258, 260, 261, 264, 266, 271, 273, 275, 277, 278, 279, 280, 281, 282, 283.

TABLE-US-00007 TABLE 7 Compound Nr. LC-MS: M+ 47 420 55 472 110 500 126 461 135 477 154 508 155 524 162 554 166 542 171 582 179 518 181 610 182 510 195 470 199 460 204 418 208 494 212 434 219 484 221 442 222 518 224 458 227 474 228 459 230 417 234 422 236 380 237 479 239 437 240 456 243 555 244 598 245 556 246 584 247 542 248 414 249 378 250 420 253 515 256 458 257 435 258 432 260 444 261 440 264 494 266 456 271 473 273 478 275 476 277 485 278 503 279 702 280 610 281 510 282 638 283 538

EXAMPLE 17

Determination of the Preventive Activity (7 days) of Compounds Having Formula (I) Against Plasmopara viticola on Vines

[0363] Leaves of vine plants, Merlot variety, grown in pots, in a conditioned environment (20?1? C., 70% R.H.) were treated by spraying both sides of the leaves with the products in question.

[0364] 7 days after the treatment, the plants were inoculated with an aqueous suspension of Plasmopara viticola spores (200,000 spores/cc) by spraying both sides of the leaves with a compressed air gun.

[0365] After remaining 24 hours in a humidity-saturated environment, at 21? C., the plants were transferred for the incubation period (7 days) in a conditioned environment with 70% R.H. and at 24? C.

[0366] After this period of time, the external symptoms of the pathogen appeared and it was therefore possible to evaluate the intensity of the infection.

[0367] The fungicidal activity is expressed as a percentage of the reduction, compared to untreated seedlings, in the area of the leaf area affected by the disease (100=complete effectiveness, 0=zero effectiveness).

[0368] Table 8 indicates the results obtained by carrying out the test described with compounds Nr. 46, 156, 165 and 249 in comparison with the compound CR1 described in WO2016109257 (Nr. 145)

CR1: Florypicoxamid

[0369]

TABLE-US-00008 TABLE 8 Compound Nr. ppm P7Activity 46 30 100 125 100 156 30 100 125 100 165 30 100 125 100 249 30 100 125 100 CR1 30 10 125 40

EXAMPLE 18

Determination of the Preventive Fungicidal Activity (5 days) of Compounds Having Formula (I) Aagainst Puccinia Recondita on Wheat

[0370] Leaves of wheat plants of the Salgemma variety, grown in pots in a conditioned environment at 20? C. and 70% of Relative Humidity (RH), were treated by spraying both sides of the leaves with the compound under examination dispersed in a hydroacetone solution at 20% by volume of acetone.

[0371] After remaining 5 days in a conditioned environment, the plants were sprayed on both sides of the leaves with an aqueous suspension of conidia of Puccinia Recondita (2 mg of inoculum per 1 ml of solution for infection).

[0372] After spraying, the plants were kept in a humidity-saturated environment at a temperature ranging from 18 to 24? C. for the incubation period of the fungus (1 day).

[0373] At the end of this period, the plants were put in a greenhouse with a relative humidity (RH) of 70% and at a temperature of 18-24? C. for 14 days

[0374] At the end of this period, the external symptoms of the pathogen appeared and it was therefore possible to proceed with the visual evaluation of the intensity of the infection, both on the parts treated directly with the products (T) and on the parts developed during the implementation of the test (NT).

[0375] The fungicidal activity is expressed as a percentage of the reduction, with respect to non-treated seedlings (blank), in the area of the leaf affected by the disease (100=full effectiveness; 0 =zero effectiveness).

[0376] All of compounds Nr. 46, 156, 165 and 249 showed an activity greater than 80% at a dose of 250 ppm.

[0377] At the same time, an evaluation of the phytotoxicity was effected (percentage of leaf necrosis) induced on the wheat seedlings by the application of the products: in this case the evaluation scale ranges from 0 (completely healthy plant) to 100 (completely necrotic plant).

[0378] Table 9 indicates the results obtained by carrying out the test described with Nr. 46, 156, 165 and 249

TABLE-US-00009 TABLE 9 P5 Activity Compound Nr. ppm T NT 46 125 98 90 250 100 99 156 125 98 93 250 100 100 165 125 95 88 250 100 100 249 125 99 95 250 100 100 CR1 125 99 90 250 100 100

EXAMPLE 19

Determination of the Preventive Fungicidal Activity (5 days) of Compounds Having Formula (I) Against Phakopsora pachyrhizi on Soya

[0379] Leaves of soya plants of the Zora variety, grown in pots in a conditioned environment at 20? C. and 70% of Relative Humidity (RH), were treated by spraying both sides of the leaves with the compound under examination dispersed in a hydroacetone solution at 20% by volume of acetone.

[0380] After remaining 5 days in a conditioned environment, the plants were sprayed on both sides of the leaves with an aqueous suspension of conidia of Phakopsora pachyrhizi (50 mg of urediniumspore in 100 ml of demineralized water with the addition of a drop of Tween surfactant).

[0381] After spraying, the plants were kept in a humidity-saturated environment at a temperature ranging from 18 to 24? C. for the incubation period of the fungus (1 day).

[0382] At the end of this period, the plants were placed in a climatic cell with R.H. 70% and a temperature of 22-24? C. for 12 days

[0383] After this period of time, the external symptoms of the pathogen appeared and it was therefore possible to proceed with the visual evaluation of the intensity of the infection, as a percentage of the leaf surface affected, considering both the two basal leaves and the first trifoliate leaf.

[0384] The fungicidal activity is expressed as a percentage of the reduction, with respect to non-treated seedlings (blank), in the area of the leaf affected by the disease (100=full effectiveness; 0=zero effectiveness).

[0385] All of compounds Nr. 46, 156, 165 and 249 showed a complete control of the pathogen at a dose of 125 ppm and a control exceeding 80% at 30 ppm.

[0386] At the same time, an evaluation of the phytotoxicity was effected (percentage of leaf necrosis) induced on the soya seedlings by the application of the products: in this case the evaluation scale ranges from 0 (completely healthy plant) to 100 (completely necrotic plant).

Table 10 indicates the results obtained by carrying out the test described with compounds Nr. 46, 156, 165 and 249

TABLE-US-00010 TABLE 10 Compound Nr. ppm P5 Activity 46 15 98 30 99 156 15 100 30 100 165 15 99 30 100 249 15 98 30 100 CR1 15 100 30 100

EXAMPLE 20

Determination of the Antifungal Activity In Vitro of Compounds Having Formula (I)

[0387] The molecules having general formula (I) were tested to evaluate their antifungal activity in vitro against the following fungi and straminipila: Alternaria alternata, Botrytis cinerea, Cercospora beticola, Colletotrichum lindemuthianum, Drechslera graminea, Fusarium graminearum, Magnaporthe oryzaena Monilia fructigena, Parastagonospora nodorum, Phytophthora infestans, Pythium ultimum, Rhizoctonia solani, Sclerotinia sclerotiorurn, Ustilago maydis, Venturia inaequalis and Zymoseptoria tritici.

[0388] The pure culture isolates were kept and stored at 4? C. in a refrigerator on agarized nutrient substrates suitable for each of them. For effecting the activity assays, the inoculum was prepared which, depending on the species of the pathogen, could be a suspension of conidia or a mycelial homogenate. For strains not easily sporulating in vitro, six to eight mycelium plugs were transferred to a grinding egg containing 6 ml of Potato Dextrose Broth (PDB) 2? and some metal balls. The suspension was homogenized with a Pulverisette 23 mini-mill (Fritsch GmbH).

[0389] For all the sporulating strains in vitro, the conidic suspension was prepared starting from a culture grown on a suitable agarized medium and under suitable conditions for stimulating sporulation. The conidia were collected in 1 ml of PDB 2? and counted under a microscope with a counting chamber in order to obtain a final inoculation of 2?10.sup.4 conidia/ml.

[0390] The concentrations tested for each active molecule were 0.001, 0.01, 0.1, 1,5 and 10 mg/l. For each molecule to be tested, a mother solution in dimethylsulfoxide (DMSO) at 80,000 mg/l was prepared which was then serially diluted in sterile demineralized water to obtain the solutions to be tested in double concentrations compared to the final doses. The inhibition tests were carried out in 96-well plates: 50 ?l of inoculum were mixed with 50 ?l of the active molecule solution in each well using the Eppendorf Multipette? System E3 serial dispenser. Four wells were used as replicates for each concentration of active ingredient. All the strains of the pathogens were grown in untreated control wells containing 50 ?l of fungal suspension and 50 ?l of sterile demineralized water. The inoculated multi-well plates were incubated at 20? C. for 72 hours (96 or 120 when necessary).

[0391] The sensitivity to the molecules was assessed as a growth inhibition of the fungus and measured in terms of absorbance immediately before and after the incubation period.

[0392] The absorbance was measured for each well using an Infinite? F50 Absorbance Reader (Tecan Group Ltd) spectrophotometer at 405 nm (for mycelial inoculae) and 492 nm (for conidic inoculae).

[0393] For each strain, the growth inhibition percentage (GIP) caused by each of the concentrations of the active ingredient was calculated using the following formula:

[00001]$\mathrm{GIP}=\frac{.Math.{\left(A_{t72-120}-A_{t0}\right)}_{untreated}.Math.-.Math.{\left(A_{t72-120}-A_{t0}\right)}_{treated}.Math.}{{\left(A_{t72-120}-A_{t0}\right)}_{untreated}}?100$

[0394] wherein At.sub.72-120 and At.sub.0 are respectively the absorbances of the treated and untreated well measured at the end and at the beginning of the incubation period. The GIP data were used for calculating EC.sub.50 which are, respectively, the effective concentrations (mg/l) of active molecule that reduce mycelial growth by 50% compared to the untreated control.

[0395] Table 11 indicates the results obtained by carrying out the test described with compounds Nr. 46, 165, 236, 239 and 248 and with the compound CR2 described in WO2016/109257 (Nr.112)

TABLE-US-00011 TABLE 11 In vitro antifungal activity, espressed as 50% effective doses (EC.sub.50 mg/l) Comp. Nr. Fungal strains 46 165 236 239 248 CR2 Alternaria alternata 0.33 7.57 Cercospora beticola 1.34 0.19 8.64 0.48 Bipolaris sorokiniana 2.68 0.11 8.0 3.6 Magnaporthe oryzae 0.2 0.79 0.64 Parastagonospora nodorum 0.001 0.01 0.009 0.006 0.008 0.24 Phytophthora infestans 0.04 0.05 1.49 1.62 1.14 Pythium ultimum 1.54 2.78 Sclerotinia sclerotiorum 0.02 0.01 0.18 0.081 5.38 Venturia inaequalis 0.25 0.18 1.77 Zymoseptoria tritici 0.02 0.007 0.095 0.067 0.17 0.14
Compound Nr.165 having general formula (I) wherein R, represents the formylaminosalicylic group, showed with respect to the identical reference compound CR2 described in patent WO2016 109257 (compound 112), wherein however R.sub.c represents a hydrogen atom, an improved in vitro antifungal activity with respect to both effectiveness and spectrum of action. Compound Nr. 165, in fact, was found to be active both against pathogens belonging to the Straminipila kingdom such as P. infestans and P. ultimum and also against other important phytopathogenic fungi such as M. oryzae and V. inaequalis. Furthermore, with respect to the effectiveness, it can be observed that for all the phytopathogenic fungi tested, the EC.sub.50 values obtained from compound Nr. 165 are much lower than those indicated by compound CR2, therefore proving to be much more active than the product belonging to the known art.