Radiation-phase-contrast imaging device
10441234 ยท 2019-10-15
Assignee
Inventors
- Koichi Tanabe (Uji, JP)
- Shingo Furui (Nara, JP)
- Hiroyuki Kishihara (Kizugawa, JP)
- Kenji KIMURA (Yamatokoriyama, JP)
- Taro Shirai (Kyoto, JP)
- Takahiro Doki (Kyotanabe, JP)
- Satoshi Sano (Uji, JP)
- Akira Horiba (Uji, JP)
Cpc classification
A61B6/4291
HUMAN NECESSITIES
G01N23/041
PHYSICS
G21K1/06
PHYSICS
International classification
G03H5/00
PHYSICS
A61B6/00
HUMAN NECESSITIES
G21K1/06
PHYSICS
G01N23/041
PHYSICS
Abstract
An X-ray phase-contrast imaging device capable of easily performing imaging of an object using X-rays of plural energies is provided. The disclosed exemplary configuration includes an X-ray source of a dual energy output type, and an FPD having a high energy X-ray detection surface and a low energy X-ray detection surface so that two types of imaging, imaging by high energy X-ray and imaging by low energy X-ray, can be performed. By imaging so as to scan the object while changing the relative position of the imaging system and the object, two types of imaging can be completed at once.
Claims
1. A radiation phase-contrast imaging device comprising: a radiation source configured to irradiate high energy radiation and low energy radiation; a grating in which an absorber absorbing radiation and extending in one direction is arranged in a direction perpendicular to the one direction, the absorber generating Talbot interference when the radiation transmits therethrough; a detection unit including a high energy radiation detection surface configured to detect a self-image of the grating related to the high energy radiation and a low energy radiation detection surface configured to detect a self-image of the grating related to the low energy radiation; and a position changing unit configured to change a relative position of an imaging system and an object so that a projection of the object moves on the detection surface while keeping a positional relationship of the radiation source, the grating, and the detection unit, the imaging system being configured by the radiation source, the grating, and the detection unit.
2. The radiation phase-contrast imaging device as recited in claim 1, wherein a distance from the high energy radiation detection surface of the detection unit to the grating and a distance from the low energy radiation detection surface to the grating are different from each other.
3. The radiation phase-contrast imaging device as recited in claim 1, wherein the position changing unit moves the detection unit in a state in which a positional relationship between the high energy radiation detection surface and the low energy radiation detection surface is maintained.
4. The radiation phase-contrast imaging device as recited in claim 1, further comprising a self-image generation unit configured to image a self-image from a detection result that the detection unit detects the radiation at the high energy radiation detection surface and a self-image from a detection result that the detection unit detects the radiation at the low energy radiation detection surface.
5. The radiation phase-contrast imaging device as recited in claim 4, further comprising a transparent image generation unit configured to generate a transparent image of the object from the self-image related to the high energy radiation and imaged by the self-image generation unit and a transparent image of the object from the self-image related to the low energy radiation and imaged by the self-image generation unit.
6. The radiation phase-contrast imaging device as recited in claim 1, wherein the radiation source is configured to simultaneously irradiate the high energy radiation and the low energy radiation onto the grating.
7. The radiation phase-contrast imaging device as recited in claim 1, wherein a first portion of the grating is positioned to receive the low energy radiation and a second portion of the grating is positioned to receive the high energy radiation, and the absorption lines of the first portion of the grating and the absorption lines of the second portion of the grating have the same pitch.
8. The radiation phase-contrast imaging device as recited in claim 1, wherein the detection unit is configured to have the low energy radiation detection surface spaced apart from a platform interposed between the radiation source and the detection unit by a first distance and the high energy radiation detection surface spaced apart from the platform by a second distance different from the first distance.
9. The radiation phase-contrast imaging device as recited in claim 8, wherein the low energy radiation detection surface and the high energy radiation detection surface each comprise a plurality of detection elements.
10. The radiation phase-contrast imaging device as recited in claim 8, wherein a first distance between the grating and the high energy radiation detection surface is different than a second distance between the grating and the low energy radiation detection surface.
11. The radiation phase-contrast imaging device as recited in claim 1, wherein the low energy radiation detection surface includes a plurality of detection elements, each detection element being formed in a rectangular shape.
12. The radiation phase-contrast imaging device as recited in claim 11, wherein the high energy radiation detection surface has a similar configuration as the low energy X-ray detection surface.
13. The radiation phase-contrast imaging device as recited in claim 1, wherein the position changing unit is further configured to change the relative position of the imaging system and a platform by linearly relatively moving the imaging system in a direction parallel to the platform.
14. The radiation phase-contrast imaging device as recited in claim 1, further comprising a self-image generation unit that is configured to generate a first self-image from a first plurality of narrow strip-like images obtained from the high energy radiation detection surface and a second self-image related to the low energy radiation from a second plurality of narrow strip-like images obtained from the low energy radiation detection surface.
15. The radiation phase-contrast imaging device as recited in claim 14, further comprising a transparent image generation unit that is configured to generate a first transparent image on the basis of the first self-image and a second transparent image on the basis of the second self-image.
16. The radiation phase-contrast imaging device as recited in claim 15, further comprising a display configured to simultaneously display the first transparent image and the second transparent image side by side.
17. A radiation phase-contrast imaging device comprising: a radiation source configured to irradiate high energy radiation and low energy radiation; at least one phase grating comprising a plurality of absorption lines extending in a first direction and configured to absorb the high energy radiation and the low energy radiation at a first plane and generate Talbot interference in response to the high energy radiation and the low energy radiation transmitting therethrough; a detection unit including a first radiation detection surface configured to detect a first self-image of the phase grating related to the high energy radiation and a second radiation detection surface configured to detect a second self-image of the phase grating related to the low energy radiation; and a position changing unit configured to change a relative position of a platform with respect to the radiation source, the phase grating, and the detection unit.
18. The radiation phase-contrast imaging device as recited in claim 17, wherein the position changing unit is further configured to change the relative position by linearly moving the platform or linearly moving the radiation source, the phase grating, and the detection together.
19. The radiation phase-contrast imaging device as recited in claim 18, wherein the at least one phase grating comprises a first phase grating positioned to receive the low energy radiation and a second phase grating positioned to receive the high energy radiation, and wherein the first phase grating comprises first absorption lines spaced apart at a first pitch and the second phase grating comprises second absorption lines spaced apart at a second pitch different from the first pitch.
20. The radiation phase-contrast imaging device as recited in claim 17, wherein the first radiation detection surface has a similar configuration as the second radiation detection surface.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) Embodiments of the present invention are shown by way of example, and not limitation, in the accompanying drawings.
(2)
(3)
(4)
(5)
(6)
(7)
(8)
(9)
(10)
(11)
(12)
DETAILED DESCRIPTION
(13) Next, embodiments for carrying out the invention will be described with reference to examples. The embodiments are described, and illustrated in the drawings, in terms of functional blocks or units. These blocks/units may be physically implemented by electronic (or optical) circuits such as logic circuits, discrete components, microprocessors, hard-wired circuits, memory elements, wiring connections, and the like, which may be formed together in a single integrated circuit (e.g., as a single semiconductor chip) or as separate integrated circuits and/or discrete components (e.g., several semiconductor chips wired together on a printed circuit board). These blocks/units may be implemented by a processor (e.g., a microprocessor, a controller, a CPU, a GPU) or processors that are programmed using software to perform various functions discussed herein. Each block/unit and/or module may be implemented by dedicated hardware, or as a combination of dedicated hardware to perform some functions and a processor to perform other functions. Also, each block/unit of the embodiments may be embodied by physically separate circuits and need not be formed as a single integrated circuit or a single processor. The X-ray in the embodiment corresponds to the radiation of the embodiment. The FPD in the embodiment is an abbreviation for a flat panel detector. The radiation phase-contrast imaging device of the present invention is suitable for fluoroscopy of a substrate for industrial use, fluoroscopy of a breast for medical use, etc., since imaging can be performed for an object M with little radiation absorption.
(14) A radiation phase-contrast imaging device according to an embodiment of the present invention will be described.
(15) The imaging device 1 is a radiation imaging device using Talbot interference. Therefore, the X-ray source 3 is configured to output an X-ray beam spreading in a phase-aligned radial pattern. Also, the distance between the phase grating 5 and the FPD 4 is set to the Talbot distance. With this setting, the self-image of the phase grating 5 will appear on the detection surface detecting the X-ray of the FPD 4. There are two detection surfaces in the present embodiment, and their functions are different. Details on this point will be described later.
(16) The self-image generation unit 11 generates self-image images P0a and P0b in which the self-image of the phase grating 5 is reflected based on the output of the FPD 4. That is, the self-image generation unit 11 is configured to treat the detection data detected by the two detection surfaces of the FPD 4 as independent images and generate two types of self-image images P0a and P0b. The generated self-image images P0a and P0b are output to the transparent image generation unit 12. Based on each of the self-image images P0a and P0b of the phase grating 5, the transparent image generation unit 12 generates transparent images P1a and P1b in which the phase-contrast of the X-ray generated in the object M is imaged.
(17) As shown in
(18) In the case of the first embodiment, the change of the relative position of the object M with respect to the imaging system 3, 4, and 5 is executed by moving the imaging system 3, 4, 5 without moving the object M. The imaging system moving control unit 14 is provided for the purpose of controlling the imaging system moving mechanism 13.
(19) The X-ray source control unit 6 is provided for the purpose of controlling the X-ray source 3. During the imaging, the X-ray source control unit 6 controls the X-ray source 3 so as to repeatedly output an X-ray beam in a pulsed manner. Every time the X-ray source 3 outputs the X-ray beam, the FPD 4 detects the X-ray that transmitted through the object M on the platform 2 and the phase grating 5 and sends the detection data to the self-image generation unit 11. As described above, the apparatus of the embodiment is configured to generate a self-image by repeatedly performing the X-ray imaging.
(20) The continuous X-ray imaging is realized by the cooperation of the X-ray source control unit 6 and the imaging system moving control unit 14. That is, by the cooperation of both the control units, the operation of moving the imaging system 3, 4, and 5 above the high energy X-ray detection surface 4a by the distance corresponding to the width of the high energy X-ray detection surface 4a in the lateral direction (the later described width in the longitudinal direction in
(21)
(22) The phase grating 5 has a plurality of absorption lines 5a absorbing an X-ray and extending in a linear manner. The absorption line 5a is arranged at a predetermined pitch in a direction perpendicular to the extending direction. The absorption line 5a is extended in the moving direction of the imaging system 3, 4, and 5.
(23) The main control unit 21 shown in
(24) <X-Ray Source of Dual Energy Output Type>
(25) According to the embodiment, the X-ray source 3 may simultaneously output X-rays different in energy. For example, the X-ray source 3 outputs a low energy X-ray (long wavelength X-ray) having an energy of 8.5 key and a high energy X-ray (short wavelength X-ray) having an energy of 22 kev. Since the low energy X-ray and the high energy X-ray are irradiated in mutually different directions, the X-ray source 3 does not output superimposed X-rays different in energy. The difference in energy between the X-rays output from the X-ray source 3 as described above is derived from the fact that X-rays to be output differ in wavelength. The X-ray source 3 may simultaneously irradiates a high energy X-ray and a low energy X-ray.
(26) In the phase grating 5, there exists a portion through which a low energy X-ray is transmitted and a portion through which a high energy X-ray is transmitted. These two portions do not overlap with each other. Between these two portions, the pitch of the absorption lines of the phase grating 5 can be made equal or can be made different.
(27) <FPD Having Two Detection Surfaces>
(28) As shown in
(29) The high energy X-ray detection surface 4b also has the same configuration as the low energy X-ray detection surface 4a described with reference to
(30) As shown in
(31) There is a condition for the self-image of the phase grating 5 to appear on the detection surfaces 4a and 4b. That is, the distance between the detection surfaces 4a and 4b and the X-ray source 3 should be the Talbot distance. This Talbot distance varies depending on the wavelength of the X-ray. That is, there is a property that the Talbot distance becomes shorter as the wavelength of the X-ray becomes longer. Therefore, according to the configuration of the embodiment, as shown in
(32) Therefore, the distance from the high energy X-ray detection surface 4b to the phase grating 5 of the FPD 4 is different from the distance from the low energy X-ray detection surface 4a to the phase grating 5. That is, the distance between the phase grating 5 and the low energy X-ray detection surface 4a is optimized for the low energy X-ray, and the distance between the phase grating 5 and the high energy X-ray detection surface 4b is optimized for the high energy X-ray. Therefore, the low energy X-ray generated at the X-ray source 3 transmits through the phase grating 5 and projects the self-image of the phase grating 5 on the low energy X-ray detection surface 4a. In the same manner, the high energy X-ray generated at the X-ray source 3 transmits through the phase grating 5 and projects the self-image of the phase grating 5 on the low energy X-ray detection surface 4b.
(33) Thus, the FPD 4 of the first embodiment is composed of two detector units, a detector unit having the low energy X-ray detection surface 4a and a detector unit having the high energy X-ray detection surface 4b. The relative position of these detector units does not change during the imaging. Further, the outputs of these detector units are independent with each other.
(34) <Self-Image Generation Unit that Generates Two Self-Images>
(35) The output of the FPD 4 related to the low energy X-ray detection surface 4a and the output of the FPD 4 related to the high energy X-ray detection surface 4b are output to the self-image generation unit 11. The self-image generation unit 11 generates a self-image image P0a based on the output of the FPD 4 related to the low energy X-ray detection surface 4a and also generates a self-image image P0b based on the output of the FPD 4 related to the high energy X-ray detection surface 4b. The self-image of the same phase grating 5 is reflected on the respective self-image images P0a and P0b.
(36) Now, imaging of the object M placed on the platform 2 as shown in
(37) Therefore, in the configuration of the embodiment, it has been devised such that imaging by the low energy X-ray and the imaging by the high energy X-ray can be performed over the entire object. The imaging by the self-image generation unit 11 may be executed by repeatedly irradiating X-rays while moving the imaging system 3, 4, and 5 with respect to the object M.
(38) The self-image generation unit 11 generates two self-image images P0a and P0b based on the detection results of the X-ray repeatedly irradiated while the imaging system 3, 4, and 5 is being moved. The self-image generation unit 11 receives from the FPD 4 the detection result of the low energy X-ray irradiated every time the X-ray is irradiated, and generates a narrow strip-like image in the moving direction of the imaging system 3, 4, and 5. As shown in
(39) In the same manner, the self-image generation unit 11 receives from the FPD 4 the detection result of the high energy X-ray irradiated every time the X-ray is irradiated, and generates a narrow strip-like image in the moving direction of the imaging system 3, 4, and 5. And the self-image generation unit 11 arranges and connects a plurality of generated strip-like images in the moving direction of the imaging system 3, 4, and 5 in chronological order of imaging to generate a self-image image P0b on which the entire region of the object M is reflected. The state in which the self-image image P0b is generated at this time is the same as shown in
(40) In this manner, the self-image generation unit 11 generates the self-image image P0a for the entire region of the object based on the detection result of the low energy X-ray detection surface 4a and also generates the self-image image P0b for the entire region of the object based on the detection result of the high energy X-ray detection surface 4b. The self-image image P0a represents the disturbance of the self-image of the phase grating observed when a low energy X-ray is irradiated to the object M, and the self-image image P0b represents the disturbance of the self-image of the phase grating when a high energy X-ray is irradiated to the object M. In this way, the self-image generation unit 11 takes the self-image from the detection result of the X-ray by the high energy X-ray detection surface 4b of the FPD 4, and takes the self-image from the detection result of the X-ray by the low energy X-ray detection surface 4a of the FPD 4.
(41) <Transparent Imaging Generation Unit for Generating Two Transparent Images>
(42) The self-image generation unit 11 sends the self-image images P0a and P0b to the transparent image generation unit 12. The transparent image generation unit 12 generates a transparent image P1a on which the transparent image of the object M is reflected on the basis of the self-image image P0a and also generates the transparent image P1b on which the transparent image of the object M is reflected on the basis of the self-image image P0b. In this way, the transparent image generation unit 12 generates a transparent image of the object M from the self-image related to the high energy X-ray imaged by the self-image generation unit 11, and also generates the transparent image of the object M from the self-image related to the low energy X-ray imaged by the self-image generation unit 11. The generated transparent images P1a and P1b are arranged side by side and displayed on the display 26.
(43)
(44)
(45)
(46) According to the apparatus of the embodiment, by comparing the two transparent images P1a and P1b having different imaging conditions, the state of the inside of the object M can be accurately known. That is, when it is desired to grasp the internal structure of the peripheral portion of the object M, the internal structure can be grasped by referring to the transparent image P1a, and when it is desired to grasp the internal structure of the center portion of the object M, the internal structure can be grasped by referring to the transparent image P1b.
(47) As described above, according to the embodiment, it is possible to provide a radiation phase-contrast imaging device capable of easily performing imaging of an object using X-rays of a plurality of energies. That is, the configuration of the embodiment includes an X-ray source 3 of a dual energy output type, and an FPD 4 having a high energy X-ray detection surface 4b and a low energy X-ray detection surface 4a so that two types of imaging, imaging by high energy X-ray and imaging by low energy X-ray, can be performed. By imaging so as to scan the object M while changing the relative position of the imaging system and the object M, two types of imaging can be completed at once.
(48) The present invention can also be applied to a transparent image using small-angle scattering, and therefore small-angle scattering will be briefly described first. When applying an X-ray to an object, there occurs a phenomenon in which the traveling direction of some X-rays changes in the object. Such a phenomenon is called X-ray scattering. Among the X-ray scattering, scattering in which the traveling direction hardly changes is called small-angle scattering. Such X-ray related to small-angle scattering is detected by the FPD 4 and reflected on the self-image images P0a and P0b generated by the self-image generation unit 11. The transparent image generation unit 12 can extract a component related to the small-angle scattering from each of the self-image images P0a and P0b to generate a small-angle scattering image. There are two small-angle scattering images generated at this time, one generated based on the self-image image P0a and the other generated based on the self-image image P0b.
(49) When considering the phenomenon of small-angle scattering, it is easy to understand if the structure constituting the inside of the object is considered as particles. It is considered such that small-angle scattering will occur when an X-ray hits the particles. Small-angle scattering X-ray generated by irradiating a low energy X-ray to an object is derived from particles having a relatively large diameter among the particles constituting the inside of the object. On the other hand, small-angle scattering X-ray generated by irradiating a high energy X-ray to an object is derived from particles having a relatively small diameter among the particles constituting the inside of the object. Thus, when changing the wavelength of the X-ray used for imaging a small-angle scattering image, the image reflected on the small-angle scattering image changes. The small-angle scattering image took by irradiating a low energy X-ray to the object is one in which large diameter particles constituting the inside of the object are reflected. On the other hand, the small-angle scattering image took by irradiating a high energy X-ray to the object is one in which small diameter particles constituting the inside of the object are reflected.
(50) According to the configuration of the embodiment, it is possible to simultaneously perform imaging using a low energy X-ray and imaging using a high energy X-ray, so two small-angle scattering images can be acquired at the same time. That is, from the self-image image P0a related to a low energy X-ray, a small-angle scattering image in which particles of a large diameter constituting the inside of the object are reflected can be generated. On the other hand, from the self-image image P0a related to a high energy X-ray, a small-angle scattering image in which particles of a small diameter constituting the inside of the object are reflected can be generated.
(51) The present invention is not limited to the aforementioned configurations, and may be modified as follows.
(52) (1) According to the aforementioned embodiment, the imaging system moving mechanism 13 is configured to move the X-ray source 3 together with the FPD 4 and the phase grating 5, but the present invention is not limited thereto. It may be configured such that the relative positions of the object M and the imaging system are changed by configuring the imaging system moving mechanism 13 so as to move the FPD 4 and the phase grating 5 by tracing the locus of the circular arc so as not to change the positional relationship of the X-ray source 3, the FPD 4 and the phase grating 5. Further, it may be configured such that the relative position of the object M and the imaging system is changed by moving the platform 2 without moving the imaging system 3, 4, and 5.
(53) (2) According to the aforementioned configuration, although the object M is placed between the X-ray source 3 and the phase grating 5, the present invention is not limited to the configuration. The platform 2 and the object M may be placed between the phase grating 5 and the FPD 4.
(54) (3) According to the aforementioned embodiment, the X-ray source 3 simultaneously irradiates a low energy X-ray and a high energy X-ray, but the present invention is not limited to this configuration. It may be configured such that the X-ray source 3 alternately irradiates a low energy X-ray and a high energy X-ray.
(55) (4) According to the aforementioned embodiment, although the low energy X-ray detection surface 4a and the high energy X-ray detection surface 4b include detection elements arranged with the same pitch, the present invention is not limited to this configuration. It may be configured such that the pitch of the detection elements is changed between the detection surface 4a and the detection surface 4b.
(56) (5) According to the aforementioned configuration, although it is configured such that the low energy X-ray and the high energy X-ray transmit through the same phase grating 5, the present invention is not limited to the configuration. It may be configured such that a low energy X-ray phase grating 5 through which a low energy X-ray transmits and a high energy X-ray phase grating 5 through which a high energy X-ray transmits are provided and the pitch of absorption lines constituting the low energy X-ray phase grating 5 and the pitch of the absorption lines constituting the high energy X-ray phase grating 5 are different from each other.
(57) (6) In the configuration in which phase gratings 5 having different absorption line pitches are provided, the Talbot distance related to the low energy X-ray and the Talbot distance related to the high energy X-ray may be set so as to coincide with each other. In this case, the distance from the low energy X-ray detection surface 4a to the phase grating 5 is different from the distance from the high energy X-ray detection surface 4b to the phase grating 5 coincide.
(58) (7) According to the above-described embodiment, the FPD 4 is configured to directly observe the self-image, but the present invention is not limited to this configuration. It may be configured such that an absorption grating is arranged so as to cover the detection surfaces 4a and 4b and the moire generated between the self-image and the absorption grating is observed with the detection surfaces 4a and 4b.
(59) (8) The above-described X-ray source 3 is a dual energy output type, but the present invention is not limited to this configuration. In place of this, the X-ray source 3 of the present invention may be configured to output a wideband X-ray. Since such an X-ray source 3 outputs X-rays of various wavelengths, monochromatic X-ray is not incident on a low energy radiation detection surface 4a and a high energy radiation detection surface 4b. However, the wavelength of X-ray that can be involved in generating the self-image depends on the distance from the phase grating 5 to the detection surfaces 4a and 4b. Therefore, also in the present invention, it is a low energy X-ray having a certain wavelength that reflects the self-image on the low energy radiation detection surface 4a, and it is a high energy X-ray having a certain wavelength that reflects the self-image on the low energy radiation detection surface 4b. In this manner, the transparent images P1a and P1b described with reference to
DESCRIPTION OF REFERENCE SYMBOLS
(60) 3: X-ray source (radiation source) 4: FPD (detection unit) 4a: low energy radiation detection surface 4b: high energy radiation detection surface 5: phase grating (grating) 11: self-image generation unit (self-image generation unit) 12: transparent image generation unit (transparent image generation unit) 13: imaging system moving mechanism (position changing unit)