ORAL VETERINARY PHARMACEUTICAL AND NUTRACEUTICAL COMPOSITIONS

Abstract

This invention provides an oral veterinary pharmaceutical or nutraceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion further comprising at least one component selected from taste enhancers, odour enhancers, digestive enzymes and veterinary drugs.

Claims

1. An oral veterinary pharmaceutical or nutraceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion further comprising at least one component selected from taste enhancers, odour enhancers, digestive enzymes and veterinary drugs.

2. A composition as claimed in claim 1 containing a digestive enzyme.

3. A composition as claimed in either of claims 1 and 2 containing a protein hydrolysate.

4. A composition as claimed in any one of claims 1 to 3 containing a chicken flavouring.

5. A composition as claimed in any one of claims 1 to 3 containing a beef flavouring.

6. A composition as claimed in any one of claims 1 to 3 containing a lamb flavouring.

7. A composition as claimed in any one of claims 1 to 3 containing a rabbit flavouring.

8. A composition as claimed in any one of claims 1 to 3 containing a salmon flavouring.

9. A composition as claimed in any one of claims 1 to 3 containing a pork flavouring.

10. An oral veterinary pharmaceutical composition comprising a physiologically tolerable gelled oil-in-water emulsion further comprising a veterinary drug for use in treatment of a non-human mammalian subject to combat a condition responsive to said veterinary drug.

11. A composition as claimed in any of the preceding claims wherein the oil phase of said emulsion comprises an omega-3 fatty acid or ester or salt thereof.

12. A method of treatment of a non-human mammalian subject by oral administration to said subject of an effective amount of a veterinary drug, the improvement comprising administering said drug in a physiologically tolerable gelled oil-in-water emulsion.

13. A method as claimed in claim 12 being a method of treatment of a disease of the small intestine or exocrine pancreatic insufficiency.

14. A method of dietary supplementation of a non-human mammalian animal subject which comprises orally administering to said subject at least one dietary supplement in a physiologically tolerable gelled oil-in-water emulsion.

Description

EXAMPLE 1

Basic Recipe for Veterinary Dosage Form:

[0030]

TABLE-US-00001 Components (% by wt.) Gelatin 7.5% Gum arabicum 3.5% Fish protein hydrolysate 0-22% Chicken broth powder 0-22% Salt 0-2% Flavouring 1% Colour 0.5% Preservatives 0-3% Oil 5 to 35% Water to 100%

[0031] Oil (e.g. plant or marine animal oil) is emulsified with the aqueous phase containing gelatin, gum arabicum, proteins, salt and preservatives and the emulsion is poured in aliquots of 1.5 g into elongate moulds lined with a metal/plastics laminate blister tray and allowed to set. The blister tray is thermally sealed with a metal/plastics foil cover sheet.

EXAMPLE 2

[0032] Canine and Feline Nutraceutical with Essential Fatty Acids

TABLE-US-00002 Components (% by wt.) Gelatin 7.5% Gum arabicum 3.5% Fish protein hydrolysate 0-22% Chicken broth powder 0-22% Salt 0-2% Flavouring 1% Colour 0.5% Preservatives 0-3% Triglycerides* 0-40% Ethyl esters of fatty acids* 0-40% Free fatty acids* 0-40% Monoacylglycerides* 0-40% Phospholipids* 0-40% Water to 100% *Total not to exceed 40%

[0033] Free fatty acids (e.g. omega-3 acids, in particular a mixture of DHA and EPA), ethyl esters, triacylglycerides, phospholipids, and/or monoacylglycerides of poly and mono unsaturated fatty acids are emulsified into the aqueous phase and the emulsion is poured in aliquots of 1.5 g into elongate moulds lined with a metal/plastics laminate blister tray and allowed to set. The blister tray is thermally sealed with a metal/plastics foil cover sheet.

EXAMPLE 3

[0034] Canine and Feline Nutraceutical with Essential Fatty Acids and Vitamins

TABLE-US-00003 Components (% by wt.) Gelatin 7.5% Gum arabicum 3.5% Fish protein hydrolysate 0-22% Chicken broth powder 0-22% Salt 0-2% Flavouring 1% Colour 0.5% Preservatives 0-3% Triglycerides* 0-40% Ethyl esters of fatty acids* 0-40% Free fatty acids* 0-40% Monoacylglycerides* 0-40% Phospholipids* 0-40% Vitamins 0.01-1% Water to 100% *Total not to exceed 40%

[0035] Free fatty acids (e.g. omega-3 acids, in particular a mixture of DHA and EPA), ethyl esters, triacylglycerides, phospholipids, and/or monoacylglycerides of poly and mono unsaturated fatty acids are emulsified together with the lipid-soluble vitamins into the aqueous phase and the emulsion is poured in aliquots of 1.5 g into elongate moulds lined with a metal/plastics laminate blister tray and allowed to set. The blister tray is thermally sealed with a metal/plastics foil cover sheet.

EXAMPLE 4

[0036]

TABLE-US-00004 Canine and Feline antibiotics Components (% by wt.) Gelatin 7.5% Gum arabicum 3.5% Fish protein hydrolysate 0-22% Chicken broth powder 0-22% Salt 0-2% Flavouring 1% Colour 0.5% Preservatives 0-3% Oil 5 to 35% Ciprofloxacin 180 mg/tablet* Water to 100% *Suitable for a 15 kg animal - to be adjusted for smaller/heavier animals.

[0037] Oil (e.g. plant or marine animal oils), together with ciprofloxacin, is emulsified into the aqueous phase and the emulsion is poured in aliquots of 1.5 g into elongate moulds lined with a metal/plastics laminate blister tray and allowed to set. The blister tray is thermally sealed with a metal/plastics foil cover sheet.

EXAMPLE 5

Canine and Feline Antifungals

[0038]

TABLE-US-00005 Components (% by wt.) Gelatin 7.5% Gum arabicum 3.5% Fish protein hydrolysate 0-22% Chicken broth powder 0-22% Salt 0-2% Flavouring 1% Colour 0.5% Preservatives 0-3% Oil 5 to 35% Griseofulvin 375 mg* Water to 100% *Suitable for a 15 kg animal - to be adjusted for smaller/heavier animals.

[0039] Oil (e.g. plant or marine animal oils), together with griseofulvin is emulsified into the aqueous phase and the emulsion is poured in aliquots of 1.5 g into elongate moulds lined with a metal/plastics laminate blister tray and allowed to set. The blister tray is thermally sealed with a metal/plastics foil cover sheet.

EXAMPLE 6

[0040] Canine and Feline Nutraceutical with Digestive Enzyme and Nutrients

TABLE-US-00006 Components (% by wt.) Gelatin 7.5% Gum arabicum 3.5% Fish protein hydrolysate 0-22% Chicken broth powder 0-22% Salt 0-2% Flavouring 1% Colour 0.5% Preservatives 0-3% Triglycerides* 0-40% Ethyl esters of fatty acids* 0-40% Free fatty acids* 0-40% Monoacylglycerides* 0-40% Phospholipids* 0-40% Vitamins 0.01-1% Pancreatic Lipase 10 000 U Water to 100% *Total not to exceed 40%

[0041] Free fatty acids (e.g. omega-3 acids, in particular a mixture of DHA and EPA), ethyl esters, triacylglycerides, phospholipids, and/or monoacylglycerides of poly and mono unsaturated fatty acids are emulsified together with the lipid-soluble vitamins into the aqueous phase with pancreatic lipase and the emulsion is poured in aliquots of 1.5 g into elongate moulds lined with a metal/plastics laminate blister tray and allowed to set. The blister tray is thermally sealed with a metal/plastics foil cover sheet.