Synchronizing Chest Compression and Ventilation in Cardiac Resuscitation

Abstract

Apparatus for automatic delivery of chest compressions and ventilation to a patient, the apparatus including: a chest compressing device configured to deliver compression phases during which pressure is applied to compress the chest and decompression phases during which approximately zero pressure is applied to the chest a ventilator configured to deliver positive, negative, or approximately zero pressure to the airway; control circuitry and processor, wherein the circuitry and processor are configured to cause the chest compressing device to repeatedly deliver a set containing a plurality of systolic flow cycles, each systolic flow cycle comprising a systolic decompression phase and a systolic compression phase, and at least one diastolic flow cycle interspersed between sets of systolic flow cycles, each diastolic flow cycle comprising a diastolic decompression phase and a diastolic compression phase, wherein the diastolic decompression phase is substantially longer than the systolic decompression phase.

Claims

1-2. (canceled)

3. A system for providing chest compressions and ventilations to a patient, the system comprising: a chest compressing device configured to deliver compressions during which pressure is applied to compress the patient's chest and decompressions during which approximately zero pressure is applied to the patient's chest; a ventilator configured to deliver ventilation phases of positive pressure, negative pressure, or approximately zero pressure to the airway; and a control circuitry and a processor configured to cause the ventilator and the chest compressing device to deliver the ventilations and the compressions, wherein a peak positive ventilation pressure occurs during a transition between one of the compressions and a subsequent decompression.

4. The system of claim 3, wherein the control circuitry and the processor are configured to cause the ventilator to deliver a ventilation pressure during one of the compressions that increases from approximately zero ventilation pressure at an onset of the respective compression to the peak positive ventilation pressure at or near the beginning of the subsequent decompression.

5. The system of claim 4, wherein at least a portion of the ventilation pressure varies gradually in a ramp shaped variation from the approximately zero ventilation pressure to the peak positive ventilation pressure during the transition between one of the compressions and the subsequent decompression.

6. The system of claim 3, wherein the control circuitry and the processor are configured to cause the ventilator to deliver a ventilation pressure that is negative at an onset of the decompressions.

7. The system of claim 3, wherein a ventilation pressure is approximately constant and equal to the peak positive ventilation pressure during the subsequent decompression.

8. The system of claim 7, wherein the peak positive ventilation pressure is approximately 2 kPa.

9. The system of claim 7, wherein the subsequent decompression has a duration of approximately 600 milliseconds.

10. The system of claim 3, wherein the control circuitry and processor are configured to synchronize the ventilation phases with the compressions to a timing of intrinsic electrical activity of the patient's heart.

11. The system of claim 3, wherein the negative pressure of the ventilations is delivered during a first majority of the decompressions.

12. The system of claim 3, wherein the positive pressure of the ventilations is delivered during a second majority of the compressions.

13. The system of claim 3, wherein the control circuitry and processor are configured to cause the ventilator and the chest compressing device to deliver the ventilations and the compressions such that a negative pressure ventilation phase is aligned with a decompression phase.

14. A system for providing chest compressions and ventilations to a patient, the system comprising: a chest compressing device configured to deliver compressions during which pressure is applied to compress the patient's chest and decompressions during which approximately zero pressure is applied to the patient's chest; a ventilator configured to deliver ventilation phases of positive, negative, or approximately zero pressure to the airway; and control circuitry and processor configured to cause the ventilator and the chest compressing device to deliver the ventilations and the compressions, wherein a negative pressure ventilation phase is aligned with a decompression phase.

15. The system of claim 14, wherein the control circuitry and the processor are configured to cause the ventilator to deliver a constant ventilation pressure during the negative pressure ventilation phase.

16. The system of claim 15, wherein the constant ventilation pressure during the negative pressure ventilation phase is approximately 2 kPa.

17. The system of claim 14, wherein the control circuitry and the processor are configured to cause the ventilator to deliver a ventilation pressure during one of the compressions that increases from approximately zero ventilation pressure to a maximum ventilation pressure during a transition between one of the compressions and a subsequent decompression.

18. The system of claim 14, wherein the negative pressure ventilation phase and the decompression aligned the negative pressure ventilation phase have a duration of approximately 600 milliseconds.

19. The system of claim 14, wherein the control circuitry and processor are configured to synchronize the ventilation phases with the compressions to a timing of intrinsic electrical activity of the patient's heart.

20. The system of claim 14, wherein the negative pressure of the ventilations is delivered during a first majority of the decompressions.

21. The system of claim 20, wherein the positive pressure of the ventilations is delivered during a second majority of the compressions.

22. The system of claim 14, wherein the control circuitry and processor are configured to cause the ventilator and the chest compressing device to deliver the ventilations and the compressions such that a peak positive ventilation pressure occurs during a transition between one of the compressions and a subsequent decompression

Description

DESCRIPTION OF DRAWINGS

[0020] FIG. 1 is a block diagram of one implementation of the invention.

[0021] FIG. 2 is a block diagram of the ventilator of one implementation of the invention.

[0022] FIG. 3 is a timing diagram of the integrated compression and ventilation cycles of one implementation of the invention.

[0023] FIG. 4 is a timing diagram of the integrated compression and ventilation cycles of another implementation of the invention.

DETAILED DESCRIPTION

[0024] There are a great many possible implementations of the invention, too many to describe herein. Some possible implementations that are presently preferred are described below. It cannot be emphasized too strongly, however, that these are descriptions of implementations of the invention, and not descriptions of the invention, which is not limited to the detailed implementations described in this section but is described in broader terms in the claims.

[0025] FIG. 1 shows a block diagram of one implementation. Microprocessor 14 controls in an integrated fashion the ventilator functions 15, chest compressor 12, drug infuser 14, and defibrillator/pacer 13. Physiological sensors 2, sternal motion measurement methods such as accelerometer-based sternal displacement measurement 3, and signal processing 9 to filter and process these various signals such as end-tidal carbon dioxide measurement (EtCO.sub.2) and pulse oximetry (SpO.sub.2) are used to determine the patient's 11 physiological and physical state. A separate laptop 17 may communicate with the microprocessor 14, and may, in fact, be used to control the therapy delivered by the ventilator 15, chest compressor 12, drug infusor 14, and defibrillator 13.

[0026] Referring to FIG. 2, which shows a block diagram of the ventilator portion of one implementation, microprocessor 14 controls the delivery of various therapeutic gases, compressed CO.sub.2 26, O.sub.2 25, and room air 24. Pressures for these gases are controlled by regulators 34 and mixed with valves 35 to achieved the desired partial pressures for each of the gases. A cooler/heater/humidifier 33 is provided to condition the air. In one implementation, a heat exchanger is provided that cools the gas mixture to 1-2 degrees centigrade as a means of inducing mild hypothermia. The heat exchanger may be an electrically-powered element incorporating a Peltier-effect element or may incorporate a cold storage element such as a liquid nitrogen or dry ice storage element. In the case of the cold storage element, the rate of cooling is controlled by insulating the cold storage element, providing for a heat conducting window in the insulation, and adjusting the surface area of the heat conducting window.

[0027] FIG. 3 shows a timing diagram of one implementation. Three waveforms are shown. First is the patient's ECG (the ECG shown is representative of an ECG following return of spontaneous circulation (ROSC); a very different ECG would typically be present prior to ROSC). The second waveform is the chest compression force applied by the automatic chest compression device (in the figure, compression pressure rises as the waveform moves downwardly). The third waveform is the ventilation pressure applied to the airway (in the figure, pressure is positive above the axis, and negative below the axis).

[0028] In some implementations, the compression-to-ventilation ratios can be varied from the current AHA recommendation of two ventilations every 30 seconds. For example, one ventilation may be delivered for every five chest compressions (a ratio closer to that of a normal adult).

[0029] In the implementation shown in FIG. 3, there are five chest compression cycles 48 during period 50. Each compression cycle has a 50% duty cycle of compression to decompression ratio and an 800 msec cycle length (400 msec compression phase; 400 msec decompression phase). Each cycle includes an onset of compression or downstroke (44) and an onset of decompression or upstroke (46). These compression cycles are configured to improve systolic flow, and so can be called systolic flow cycles.

[0030] Following the five systolic flow cycles, there is a diastolic flow cycle 52. The diastolic flow cycle begins with a shortened compression phase 54 of 200 msec duration, followed by a lengthened decompression phase 56 of 600 msec duration, then a second shortened compression phase 58 (200 msec), and a second lengthened decompression phase 60 (600 msec). During the diastolic flow cycle, the automatic ventilator produces a negative pressure phase 62 (600 msec) to induce a negative intrathoracic pressure (approx. 2 kPa) aligned with decompression phase 56. This results in increased venous return to the right atrium (diastolic flow), thus increasing blood flow during the subsequent compression phase 58. The ventilation pressure ramps up (64) to approximately +2 kPa during the compression phase 58 and remains constant at +2 kPa during the subsequent 600 msec decompression phase 66. In the implementation of FIG. 3, ventilation assistance is not provided during the systolic flow cycles (ventilation pressure is zero during those cycles).

[0031] FIG. 4 shows another implementation, in which systolic flow may be further enhanced by short ventilation cycles 68 synchronized with the systolic flow cycles 50. The ventilation cycles are synchronized with the compression and decompression phases of the systolic flow cycles, taking the shape of a ramp with approximately zero pressure at the onset 70 of the compression phase, and rising to a maximum positive pressure during the compression phase. In the decompression phase of the cycle, a similar triangular ventilation pressure waveform is used, with the maximum negative pressure 72 occurring just slightly prior to (approximately 40 msec prior) to the onset of the decompression phase, so that the airway pressure is definitively negative at the onset of decompression, so as to maximize diastolic reflow. This linear ramp with a zero-crossing at the onset of compression has the advantage of providing an airway that is close to a homogeneously neutral pressure at the onset of compression, so that at the compression downstroke 44 and the resultant rise in intrathoracic pressure, the airway collapses for a portion of the compression phase. By collapsing the airway, the volume of the lungs themselves are maintained during the chest compression cycle, acting effectively as bellows on each side of the heart to squeeze the heart during a compression thus enhancing systolic flow. In some implementations, chest compression is provided by a load-distributing band such as that manufactured by ZOLL Circulatory Systems of Sunnyvale Calif. The diastolic flow cycles 52 occur after a number, preferably five or six, of systolic flow cycles 50. The diastolic flow cycle may have approximately a 20-30% compression duty cycle, with a decompression phase 62 that is approximately 640 msec in duration. Subsequent to ROSC, a victim's own heart is pumping and circulating blood, but usually with reduced efficiency. In some implementations, ventilations after ROSC are delivered without compressions. But in other implementations, compressions after ROSC may also be delivered in a similar pattern to that used during cardiac arrest. The compressions after ROSC differ in two important respects: (1) they are synchronized to the QRS of the patient's ECG as shown in FIG. 3; and (2) they are of reduced compressive force. A compression of reduced force and synchronized to the ECG QRS will augment the natural flow of the patient's hemodynamics enhancing recovery.

[0032] Many other implementations other than those described above are within the invention, which is defined by the following claims. For example, different shapes and different numbers of compression and ventilation waveforms than those shown in FIGS. 3 and 4 may be used.