MRI apparatus
11543479 · 2023-01-03
Assignee
- Tesla Dynamic Coils BV (Zaltbommel, NL)
- Futura Composites B.V. (Heerhugowaard, NL)
- Umc Utrecht Holding B.V. (Utrecht, NL)
Inventors
- Dennis Klomp (Utrecht, NL)
- Edwin Versteeg (Utrecht, NL)
- Jeroen Siero (Utrecht, NL)
- Martino Borgo (Zaltbommel, NL)
Cpc classification
G01R33/3858
PHYSICS
G01R33/561
PHYSICS
G01R33/3854
PHYSICS
G01R33/3607
PHYSICS
G01R33/485
PHYSICS
International classification
G01R33/561
PHYSICS
G01R33/36
PHYSICS
Abstract
An MRI system coil insert 2 for use within a bore B of a main MRI system 1, the coil insert 2 comprising at least one gradient coil, for creating a spatially varying magnetic field along a respective axis and being arranged to be electrically driven at an ultrasonic frequency.
Claims
1. An MRI system coil insert for use within a bore of a main MRI system, the coil insert comprising at least one gradient coil for creating a spatially varying magnetic field along a respective axis and being arranged to be electrically driven at an ultrasonic frequency, wherein the insert comprises a first gradient coil and a second gradient coil, at least one first capacitor is electrically connected to the first gradient coil so as to make the first gradient coil resonant at a first predetermined ultrasonic frequency, and at least one second capacitor is electrically connected to the second gradient coil so as to make the second gradient coil resonant at a second predetermined ultrasonic frequency, and wherein the first predetermined ultrasonic frequency is different from the second predetermined ultrasonic frequency and the difference in frequency between the first predetermined ultrasonic frequency and the second predetermined ultrasonic frequency is an inaudible frequency.
2. The MRI system coil insert according to claim 1 having a central region free from gradient coil windings.
3. The MRI system coil insert according to claim 2 having a window in the insert through which a patient can see when the head of the patient is located within the insert.
4. The MRI system coil insert according to claim 1 which comprises a Z gradient coil for creating a spatially varying magnetic field along the main axis of the insert.
5. The MRI system coil insert according to claim 4 in which the Z gradient coil comprises a first set of windings provided at a first end of the insert and a second set of windings provided at a second end of the insert.
6. The MRI system coil insert according to claim 4 in which the Z gradient coil comprises more than two sets of windings, the windings being arranged to allow the provision of a segmented gradient on the Z-axis.
7. The MRI system coil insert to claim 1 which comprises an X gradient coil or a Y gradient coil for creating a spatially carrying magnetic field transverse to the main axis of the insert.
8. The MRI system coil insert to claim 1 which comprises a first gradient coil for creating a spatially varying magnetic field along a first respective axis and a second gradient coil for creating a spatially varying magnetic field along a second respective axis.
9. The MRI system coil insert according to claim 5 further comprising an X gradient coil or a Y gradient coil for creating a spatially varying magnetic field transverse to the main axis wherein the X or Y gradient coil comprises a third set of windings and a fourth set of windings which are provided on radially opposite sides of the insert and axially between the first and second sets of windings of the Z gradient coil.
10. The MRI system coil insert according to claim 9 in which a circumferential spacing is provided between the third and fourth set of windings such that there is a region in the insert free from windings of the Z gradient coil and windings of the X or Y gradient coil.
11. The MRI system coil insert according to claim 9 in which each of the third set of windings and the fourth set of windings comprises a plurality of helically wound turns where each complete turn has an inner arcuate segment, a first end segment extending outwardly to an outer arcuate segment, and a second end segment extending inwardly from the outer arcuate segment to a corresponding inner arcuate segment of a subsequent turn.
12. An MRI system arrangement comprising an MRI system having a main bore, and an MRI system coil insert according to claim 1 for use within said bore.
13. An MRI system coil insert arrangement comprising a coil insert for use within a bore of a main MRI system, the coil insert comprising at least one gradient coil for creating a spatially varying magnetic field along a respective axis and being arranged to be electrically driven at an ultrasonic frequency, and a signal generator arrangement for electrically driving the at least one gradient coil at ultrasonic frequencies, wherein the insert comprises a first gradient coil and a second gradient coil, and the signal generator arrangement is arranged to drive the first gradient coil at a first selected ultrasonic frequency and to drive the second gradient coil at a second selected ultrasonic frequency, the first selected ultrasonic frequency is different from the second selected ultrasonic frequency and the difference in frequency between the first selected ultrasonic frequency and the second selected ultrasonic frequency is an inaudible frequency.
14. The MRI system coil insert arrangement according to claim 13 in which at least one first capacitor is electrically connected to the first gradient coil so as to make the first gradient coil resonant at a first predetermined ultrasonic frequency, and at least one second capacitor is electrically connected to the second gradient coil so as to make the second gradient coil resonant at a second predetermined ultrasonic frequency, wherein the first selected frequency is the same as the first predetermined frequency and the second selected frequency is the same as the second predetermined frequency.
15. An MRI system coil insert arrangement according to claim 13 which further comprises a Z gradient coil for creating a spatially varying magnetic field along the main axis of the insert, wherein the Z gradient coil comprises a first set of windings provided at a first end of the insert and a second set of windings provided at a second end of the insert and the windings of the Z gradient coil and the signal generator arrangement are arranged to provide a segmented gradient on the Z-axis.
16. An MRI system arrangement comprising an MRI system having a main bore, and an MRI system coil insert arrangement according to claim 13 with the coil insert arranged for use within said bore.
17. An echo planar spectroscopic imaging system comprising an MRI system arrangement having an acquisition section for acquiring magnetic resonance data and a reconstruction section for reconstructing images and spectroscopic information from acquired magnetic resonance data, the acquisition section comprising: an RF transmission arrangement arranged to output single- or multi-band RF pulses; a first gradient coil arranged to be driven at an ultrasonic frequency for creating a spatially varying magnetic field along a first respective axis and a second gradient coil arranged to be driven at an ultrasonic frequency for creating a spatially varying magnetic field along a second respective axis; and a signal generator arrangement for electrically driving the first gradient coil at a first selected ultrasonic frequency and driving the second gradient coil at second selected ultrasonic frequency, wherein the signal generator arrangement is configured, as part of acquiring the magnetic resonance data, to apply, during a readout period, a plurality of chirp pulses to the first gradient coil and to apply a plurality of chirp pulses to the second gradient coil so as to achieve spectral encoding and spatial encoding on the first and second respective axes; and the acquisition section is arranged to readout magnetic resonance data during said readout period and the reconstruction section is arranged to reconstruct an image and spectral information relating to the image from the magnetic resonance data readout during said readout period.
18. The echo planar spectroscopic imaging system according to claim 17 in which each chirp pulse has a length of less than 10 milliseconds.
19. The echo planar spectroscopic imaging system according to claim 17 in which the signal generator arrangement is configured to apply at least 10 chirp pulses during said readout period.
20. The echo planar spectroscopic imaging system according to claim 17 in which the acquisition section is to be arranged to acquire magnetic resonance data during a plurality of readout periods in order to produce a set of magnetic resonance data, and the acquisition section is arranged to cause the RF transmission arrangement to output a single- or multi-band RF pulse before the start of each readout period and the acquisition is arranged to apply, during each readout period, a respective plurality of chirp pulses to the first gradient coil and to apply a respective plurality of chirp pulses to the second gradient coil so as to achieve spectral encoding and spatial encoding on the first and second respective axes.
21. The echo planar spectroscopic imaging system according to claim 17 in which the first selected ultrasonic frequency is different from the second selected ultrasonic frequency.
22. The echo planar spectroscopic imaging system according to claim 21 in which the difference in frequency between the first selected ultrasonic frequency and the second selected ultrasonic frequency is an inaudible frequency.
23. The echo planar spectroscopic imaging system according to claim 17 in which the acquisition section comprises at least one first capacitor electrically connected to the first gradient coil so as to make the first gradient coil resonant at a first predetermined ultrasonic frequency, and at least one second capacitor electrically connected to the second gradient coil so as to make the second gradient coil resonant at a second predetermined ultrasonic frequency.
24. The echo planar spectroscopic imaging system according to claim 23 in which the first selected frequency is the same as the first predetermined frequency and the second selected frequency is the same as the second predetermined frequency.
25. The echo planar spectroscopic imaging system according to claim 17 in which the acquisition section further comprises a third gradient coil arranged to be electrically driven for creating a spatially varying magnetic field along a third respective axis and the signal generator arrangement is arranged for electrically driving the third gradient coil to provide spatial encoding on the third respective axis to allow selection of a slice in the subject under investigation from which the above mentioned magnetic resonance data, or set of magnetic resonance data is acquired during the respective readout period or respective plurality of readout periods.
26. The echo planar spectroscopic imaging system according to claim 17 in which the MRI system arrangement comprises an MRI system having a main bore and an MRI system coil insert arrangement for use within said bore, said insert comprising the first gradient coil and the second gradient coil.
27. The echo planar spectroscopic imaging system according to claim 17 in which the MRI system arrangement comprises an MRI system having a main bore and an MRI system coil insert for use within said bore, said coil insert comprising at least one gradient coil for creating a spatially varying magnetic field along a respective axis and being arranged to be electrically driven at an ultrasonic frequency.
28. A method of echo planar spectroscopic imaging using an MRI system arrangement having an acquisition section for acquiring magnetic resonance data and a reconstruction section for reconstructing images and spectroscopic information from acquired magnetic resonance data, the method comprising: applying a single- or multi-band RF pulse to a subject under investigation; electrically driving a first gradient coil arranged at a first ultrasonic frequency for creating a spatially varying magnetic field along a first respective axis and electrically driving a second gradient coil at a second ultrasonic frequency for creating a spatially varying magnetic field along a second respective axis; as part of acquiring magnetic resonance data, applying, during a readout period a plurality of chirp pulses to the first gradient coil and a plurality of chirp pulses to the second gradient coil so as to achieve spectral encoding and spatial encoding on the first and second respective axes; reading out magnetic resonance data during said readout period; and reconstructing an image and spectral information relating to the image from the magnetic resonance data readout during said readout period.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying drawings in which:
(2)
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(5)
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DETAILED DESCRIPTION
(8)
(9) The MRI system insert 2 is arranged to be supplied and used in cooperation with existing MRI systems. This is of course commercially advantageous since it means that existing MRI systems may be adapted to make use of the present ideas rather than a whole new MRI system needing to be developed. That said, in alternatives, an MRI system arrangement shown in
(10) In
(11) Various different forms of insert may be provided.
(12) The insert 2′ shown in
(13) The lack of Z coil windings in a central region between the first set of windings 2z1 and second set of windings 2z2 can lead to a sub-optimal field but it has been determined that in at least some circumstances these imperfections can be tolerated. As an example, with the relatively small space in between the first set of windings 2z1 and 2z2 in an insert designed for use of examination of a person's head, these imperfections can be tolerated.
(14) The insert 2 shown in
(15) In both the insert 2 of
(16) The winding pattern of the windings 2x1, 2x2 of the X gradient coil 2x of the insert 2 of
(17)
(18) It will be seen that the arc of each inner arcuate segment has the same radius as that of the other inner arcuate segments. Similarly the arc of each outer arcuate segment has the same radius as that of the other outer arcuate segments. The radius of the arc of the inner segments is smaller than that of the outer segments.
(19) This winding arrangement leads to a longer linear region in the axial direction of the insert than in prior art winding arrangements and allows a larger circumferential spacing between the ends of the two sets of windings 2x1 , 2x2 than in the patterns of the prior art. There can be compromises in the nature of the field which is produced by such windings but it has been found that the benefits outweigh these issues in the present systems.
(20) The insert 2 shown in
(21) Further in an insert 2′ of the type shown in
(22) The MRI system arrangement comprises a signal generator arrangement 4, which is provided for driving the gradient coils 2z, 2x of the insert 2.
(23) In commercial terms, this signal generator arrangement 4 may be provided along with the insert 2 and together these can be considered as an MRI system coil insert arrangement which can be used in an existing MRI system 1. Of course, again in other alternatives, where a complete system is developed, a separate signal generator arrangement may be unnecessary and instead this may be incorporated into systems provided within the main MRI system.
(24) The signal generator arrangement 4 is arranged for driving the gradient coils 2z, 2x in the insert 2 at ultrasonic frequencies. That is to say frequencies above the audible range.
(25) Where there are two or more gradient coils in the insert 2, for example in the insert 2 of the type shown in
(26) Alternatively, and preferably, where there are two gradient coils, say the two gradient coils 2z, 2x in the insert 2, the signal generator arrangement 4 is arranged for driving these at respective different ultrasonic frequencies.
(27) As an example, in some embodiments a single ultrasonic frequency might be used and set at 20.2 kHz. In other embodiments where two different frequencies are used, these might for example be 22 kHz on the one hand and 19.9 kHz on the other hand—one being used to drive the X gradient coil 2x and one being used to drive the Z gradient coil 2z. In practice, as will be appreciated, there is quite a lot of freedom in which frequencies might be selected.
(28) However, it has been determined that it is particularly advantageous if first, two different frequencies are selected and second, if the difference between these two different frequencies is itself an inaudible frequency. This is because, as mentioned in the introduction, preferable spatial encoding can be achieved where the two frequencies are different and having the difference in frequency in the inaudible range avoids the generation of audible “beats” signals being created between sound which is generated at the two selected inaudible frequencies. Typically, the two frequencies may be selected so that the difference in the frequency is below the human hearing range. That is to say, the difference in frequency is 20 Hz or less.
(29) As schematically illustrated in
(30) Note that the idea of making a gradient coil resonant at a predetermined frequency encompasses a situation where the gradient coil is one electrical entity driven by one signal generator and where the gradient coil is made up of a plurality of separate electrical entities that may be individually driven. Thus where there are say plural independent windings in a gradient coil each will be made resonant by provision of an appropriate capacitor.
(31) In the present arrangement no RF shielding is provided in the insert 2 or between the insert 2 and the main MRI system. This helps minimise losses due to the setting up of eddy currents which might otherwise occur when the insert gradient coils 2x, 2z are driven at ultrasonic frequencies. At the same time, the insert, and in particular gradient coils 2x, 2z, are relatively transparent to the signals to be transmitted and received by the main MRI system. Thus, operation of the main MRI system may continue with the insert 2 in position within the bore B of the main MRI system.
(32) In general terms minimising the amount of electrically conductive materials in the vicinity of the insert gradient coils 2x, 2z (or any gradient coils to operate at ultrasonic frequencies) helps improve efficiency by minimising the effect of eddy currents. As spacing between a gradient coil being driven at ultrasonic frequencies and metal objects increases, the problem is reduced. Thus, in the present arrangement, the fact that active gradient field shielding is sub-optimal or even absent toward the main MRI system and there are other metal objects in the main MRI system can be tolerated. This desire to minimise metal in the vicinity of the ultrasonically driven gradient coils, i) makes it less than obvious that using such frequencies is practical, and ii) makes their inclusion in an insert rather than a main MRI machine more convenient in at least some circumstances.
(33)
(34) Here the Z gradient coil comprises four sets of windings 2z1-2z4 each having the same construction of the sets of Z windings 2z1, 2z2 described above. Again, these windings are arranged to be driven by the signal generator arrangement 4 and arranged to be made resonant at the selected driving frequency by the inclusion of one or more capacitor (not shown).
(35) In this case rather than a monotonically changing Z gradient field being set up in the insert by the Z gradient coil as is the case traditionally and in the inserts described above in relation to
(36) Operation of the MRI system arrangement will now be described, following a brief introduction of the main MRI system 1.
(37) In general terms the main MRI system 1 comprises an acquisition section I for acquiring magnetic resonance data and a reconstruction section R for reconstructing images and spectroscopic information relating to those images from the acquired magnetic resonance data. In the arrangement shown in
(38) The elements of the acquisition section I in the main MRI machine 1 in general terms comprises a magnet and coil arrangement 5 and a control system 6. The control system 6 has an output section 61 for controlling operation of the magnet and coil arrangement 5 and a receiver section 62 for receiving information back from the magnet and coil arrangement 5. In the present arrangement where the coil insert 2 is being used, the output section 61 also issues control signals to the signal generator arrangement 4 and in some embodiments the receiver section 62 might also receive output from the insert 2 although this is optional. In the arrangement now described receiving of the magnetic resonance data, is carried out in the main MRI machine 1 itself.
(39) As alluded to above in alternatives the components of the insert 2 and signal generator arrangement may be incorporated into an MRI machine itself.
(40) It will be appreciated that the MRI machine will typically comprise one or more “computer” for controlling operation and processing received data. Each such computer may comprise a processor, memory, and at least one data storage device. The control system 6 may be a computer implemented. The reconstruction section R may be computer implemented.
(41) The magnet and coil arrangement 5 comprises a main magnet 51 for creating a static field, X, Y and Z gradient coils 52, radio frequency transmitter coils 53 and radio frequency receiver coils 54.
(42) In operation the output section 61 delivers driving currents to the gradient coils 52 and causes appropriate radio frequency transmit pulses to be output by the transmit coil 53, whilst the receiver section 62 receives input from the receiver coils 54.
(43) In the present embodiment the output section 61 also provides a control triggering signal to the signal generator arrangement 4 to allow it to time appropriately the generation of gradient driving signals for driving the insert gradient coils 2x, 2z.
(44) In principle, any combination of the gradient coils 52 of the main MRI system 1 and gradient coils 2x, 2z of the insert 2 may be used to give a desired encoding effect.
(45) Most typically, perhaps, where the insert 2 includes an X gradient coil 2x and a Z gradient coil 2z, these might be used in combination with the Y gradient coil 52y of the main MRI machine 1.
(46) Thus, in a particular example, the gradient coil 52y of the main MRI machine 1 may be used for spatial encoding in order to select a particular slice in a subject for investigation and the Z and X gradient coils 2z, 2y in the insert 2 can be used for spatial encoding within that slice.
(47) In a situation where the insert includes only a Z gradient coil (say in the insert shown in
(48) In other situations, both gradient coils on one particular axis in the main MRI machine 1 and the insert 2 might be used together.
(49) For example, the insert shown in
(50) In the above situations the gradient coils 52 in the main MRI machine 1 will be driven at conventional frequencies whilst the gradient coils in the insert 2 are driven at ultrasonic frequencies.
(51)
(52) In this technique, the Z gradient coil 2z of the insert 2 is used together with the X gradient coil of the insert 2x and the Y gradient coil 52y of the main MRI machine 1. The timing chart 6, shows the signals applied to these gradient coils schematically when carrying out the technique of
(53) Further, in the timing chart RF it indicates the signals applied using the transmission coils 53 of the main MRI machine 1.
(54) At the start of each repetition period (TR) a multiband pulse is applied by the RF transmission coils 53 and a slices selection pulse is applied to the Y gradient coil 52y of the MRI machine 1. Then in a following read-out period a respective plurality of chirp pulses is applied on the one hand to the Z gradient coil 2z of the insert 2 and on the other hand to the X gradient coil 2x of the insert 2. In the present embodiment each chirp has a length of 500 microseconds and a total of 200 such chirps are applied to each of the Z gradient coils and X gradient coils 2z, 2x, in the read-out period.
(55) In the present embodiment each of the chirps is of the same waveform as each of the other of the chirps and the chirps on the Z gradient coil 2z and the X gradient coil 2x are applied in phase with each other. However, other possibilities are usable.
(56) The goal in applying the chirps is to capture large K-space (amplitude per axis defines spatial resolution in that axis) and distance between K-space points/circles (decaying amplitude defines field of view).
(57) With this technique all spatial encoding can be defined in each chirp while spectral information is encoded over the group of chirps, i.e. over the 200 chirps in this example. The number of chirps and their length and the aggregate length of the chirps will determine the spectral bandwidth and resolution. Thus, in the current example, where the length of each chirp is 500 microseconds, the bandwidth will be 2 kHz, and with the aggregate length of chirps of 100 milliseconds this will result in a resolution of in the order of 10 Hz (excluding relaxation and other small order effects).
(58) In another embodiment each chirp may be one millisecond in length. In such a case, if 200 chirps are again applied, this will result in a bandwidth of 1 kHz and resolution of in the order of 5 Hz rather than 10 Hz in the example above.
(59) Each chirp consists of a limited time varying amplitude application of the ultrasonic frequency at which the respective insert gradient coil 2z, 2x is arranged to run. In this example, the two ultrasonic frequencies are the same although in other cases they may be different, yielding the additional benefits mentioned above.
(60) In the present embodiment four shots are used to increase the accuracy of the results as indicated in the timing chart. A second multiband pulse in MB2 is provided that the start of the second shot and again an appropriate slice selection signal is applied to the Y gradient coil 52y of the main MRI machine 1. Following this a second sequence of chirps is applied to the Z gradient coil and X gradient coil 2z, 2x of the insert 2 during the read-out period of this second shot. The whole process is repeated again in third and fourth shots so that acquired magnetic resonance data may be fed to the reconstruction section R for reconstruction of the image and spectral data associated with the image. The reconstruction system R may be arranged under software for carrying out SENSE (Sensitivity Encoding) reconstruction.
(61) If it is desired then further runs as described above may be carried out in order to obtain more data with a view to improving signal to noise ratio.
(62) Alternately or in addition, further runs may be carried out in respect of different “Y-slices” of the subject. That is to say a different set of offset frequencies for slice selection may be applied to the RF coil 54 of the MRI machine 1 in order to select a second batch of slices for investigation and so on.
(63) It will be noted that with this technique spatial encoding is carried out in each chirp and complete spatial encoding and spectral encoding for a set of slices may be carried out in a total of in the order of 100 milliseconds, where only one shot is used, or in the order of 400 milliseconds, where four shots are used as in the example shown in
(64) This means that image data and spectral data collected over a very short period can be considered. This can help avoid information being lost or confusion in the results which would occur in more conventional techniques where much longer encoding times are required. In a more traditional echo planar spectroscopic imaging technique, the data is encoded one voxel at a time over an area of interest with spatial encoding carried out to start with to in effect select a particular voxel, then spectroscopic sampling taking place in respect of that voxel before moving on to the next voxel. This leads to a much longer investigation period of in the order of several seconds.
(65) While the present disclosure has been illustrated and described with respect to a particular embodiment thereof, it should be appreciated by those of ordinary skill in the art that various modifications to this disclosure may be made without departing from the spirit and scope of the present disclosure.