Integrated intra-dermal delivery, diagnostic and communication system

Abstract

In one embodiment, an IDDC system utilizes an intelligent therapeutic agent delivery system comprised of one, but more likely an array of cells containing therapeutic agent(s) and/or diagnostic agents(s); an integrated bio-sensing system designed to sample and analyze biological materials using multiple sensors that include both hardware and software components. The software component involves biomedical signal processing to analyze complex liquid mixtures and a microcontroller(s) acts as interface to the biosensors, to the therapeutic delivery elements, and to a communications system(s) for the purpose of controlling the amount of therapeutic agent to deliver and also to provide information in a useful form to interested parties on the progress of therapy and compliance thereto. The synergistic effect of combining the above describe elements is expected to dramatically improve patient compliance with prescribed therapy, quality and timeliness of care provided by physicians, and at the same time reduce the cost of providing effective healthcare to IDDC system users, thereby improving profitability for Managed Care organizations and pharmaceutical companies utilizing the system.

Claims

1. An intra-dermal delivery system comprising: a plurality of drug delivery devices that are arranged in an array, the plurality of drug delivery devices for intra-dermally delivering at least one drug below a stratum corneum, the at least one drug being stored in at least one storage cell within each of the plurality of drug delivery devices, each drug delivery device of the plurality of drug delivery devices having a lancet and an actuator causing selective movement of a respective drug delivery device to deliver the at least one drug contained in the at least one storage cell of the respective drug delivery device below the stratum corneum; a programmable controller in communication with the plurality of drug delivery devices for controlling the actuation of the actuators of the plurality of drug delivery devices; and a biofeedback device that is in communication with the programmable controller and includes at least one biosensor that is configured to measure at least one bio-property of a patient, wherein the programmable controller is programmed based on patient information to deliver the at least one drug at a prescribed time or based on a signal received from the biofeedback device; wherein the actuator of each drug delivery device of the plurality of drug delivery devices comprises a first actuating element and a second actuating element, and wherein each at least one storage cell includes the first actuating element associated therewith; and the lancet of each drug delivery device of the plurality of drug delivery devices has a delivery conduit defined by an entrance and an exit defined at a sharp distal end of the lancet, each lancet having the second actuating element associated therewith; wherein at least one of the first and second actuating elements is energized by a source of power to cause the first and second actuating elements to move together resulting in the lancet being driven toward and through the at least one storage cell so as to cause the one respective drug stored in the at least one storage cell to flow into the entrance, through the lancet to the exit for releasing the one respective drug below the stratum corneum.

2. The system of claim 1, wherein the first and second actuating elements comprise one of first and second magnetic members and first and second piezoelectric elements.

3. The system of claim 1, wherein the biofeedback device is in wireless communication with the programmable controller.

4. The system of claim 1, wherein the at least one storage cell includes a flexible stable membrane that holds the one respective drug and the first actuating element is a magnetic membrane disposed along one surface of the flexible stable membrane.

5. The system of claim 1, wherein the lancet of each drug delivery device of the plurality of drug delivery devices has a base portion on which the second actuating element is disposed and is located opposite the sharp distal end such that the entrance is located between the base portion and the sharp distal end.

6. The system of claim 5, wherein each drug delivery device of the plurality of drug delivery devices includes a biasing member that is coupled to an underside of the base portion and in contact with the lancet above the entrance, the biasing member being configured to store energy when the respective drug delivery device is in an active mode due to energizing the actuator, and upon the actuator being de-energized the biasing member is configured to release its stored energy and cause the lancet to retract from the at least one storage cell.

7. The system of claim 1, wherein the programmable controller is configured to sequentially signal the actuator of each of the plurality of drug delivery devices to cause sequential actuation of a prescribed number of the plurality of drug delivery devices.

8. The system of claim 1, wherein the plurality of drug delivery devices includes a first set of drug delivery devices containing a first drug and a second set of drug delivery devices containing a second drug to permit timed separate delivery of the first drug and the second drug.

9. The system of claim 1, wherein the at least one storage cell includes a flexible stable membrane that holds the one respective drug and the first actuating element is a magnetic membrane disposed along one surface of the flexible stable membrane and the second actuating element comprises a magnetic contact comprising one or more magnetic pads.

10. The system of claim 9, wherein the lancet of each drug delivery device of the plurality of drug delivery devices has a length that is approximately equal to a thickness of the stratum corneum.

11. The system of claim 9, wherein at least one of the first actuating element and the second actuating element comprises an electro-magnet and the other of the first actuating element and the second actuating element comprises at least one of a permanent magnet and a permanent magnetic layer.

12. The system of claim 9, wherein the magnetic membrane has a variable thickness with a peripheral outer edge having a greater thickness than a center portion of the magnetic membrane.

13. The system of claim 9, wherein the first actuating element and the second actuating element and the programmable controller are configured such that the first actuating element and the second actuating element can be energized multiple times in succession to create a pumping action.

14. The system of claim 1, wherein the entrance is open along a side of the lancet of each drug delivery device of the plurality of drug delivery devices and is formed perpendicular to a main longitudinal portion of the delivery conduit defined with the exit being formed at one end of the main longitudinal portion.

15. The system of claim 1, wherein in an extended position of the lancet of each drug delivery device of the plurality of drug delivery devices after either of the first or second actuating element is energized, the entrance is disposed within the at least one storage cell to permit entry of the at least one drug into the lancet of each drug delivery device of the plurality of drug delivery devices and flow to the exit, the entrance being oriented along an axis that is perpendicular to an axis that passes through the exit.

16. The system of claim 1, wherein the plurality of drug delivery devices comprises micro sized drug delivery devices.

17. The system of claim 1, wherein the plurality of drug delivery devices comprises nano sized drug delivery devices.

Description

BRIEF DESCRIPTION OF THE DRAWING FIGURES

(1) The foregoing and other features of the present invention will be more readily apparent from the following detailed description and drawings figures of illustrative embodiments of the invention in which:

(2) FIG. 1 is a side cross-sectional view of a micro/nano drug containing membrane or cell according to a transdermal delivery system according to one embodiment;

(3) FIG. 2 is a side cross-sectional view of a micro/nano drug delivery device for use with the cell of FIG. 1;

(4) FIG. 3 is side cross-sectional view of the drug delivery device proximate the cell prior to delivery of the drug;

(5) FIG. 4 is a side cross-section view of the drug delivery device inserted into the patient's skin after piecing the cell to deliver the drug to the patient;

(6) FIG. 5 is a side cross-sectional view of a micro/nano implant according to a transdermal delivery system according to another embodiment;

(7) FIG. 6 is a side cross-sectional view of a micro/nano implant according to another embodiment;

(8) FIG. 7 is a side cross-sectional view of a micro/nano implant according to another embodiment;

(9) FIG. 8 is a side cross-sectional view of a micro/nano implant according to yet another embodiment;

(10) FIG. 9 is a top plan view of an array of micro/nano drug delivery devices that are part of a transdermal delivery system;

(11) FIG. 10 is side cross-sectional view of an array of micro/nano barbed implants;

(12) FIG. 11 is schematic diagram of a biofeedback system;

(13) FIG. 12 is a side cross-sectional view of a micro/nano barb assembly with a protective gel coating;

(14) FIG. 13 is a side cross-sectional view of an applicator for use with micro/nano drug delivery devices, including the one of FIG. 12;

(15) FIG. 14 is a cross-sectional view of an alternate micro/nano drug delivery device for use with the cell of FIG. 1;

(16) FIG. 15 is a cross-sectional view of an alternate micro/nano drug delivery device according to another embodiment;

(17) FIG. 16 is a cross-sectional view of an alternate micro/nano needle according to another embodiment;

(18) FIG. 17 is a cross-sectional view of an alternate micro/nano drug delivery device according to another embodiment;

(19) FIG. 18 is a cross-sectional view of an alternate micro/nano drug delivery device depicting oscillatory movement and associated pressure differential according to another embodiment;

(20) FIG. 19 schematic diagram of the drug delivery device interfaced with biosensors, control system hardware, and communication units;

(21) FIG. 20 is a cross-sectional view of an alternate micro/nano drug delivery device depicting pressure and motion actuators;

(22) FIG. 21 is a cross-sectional view of an alternate micro/nano drug delivery device depicting piezoelectric componentry; and

(23) FIG. 22 is a cross-sectional view of an alternate micro/nano drug delivery device depicting biosensor interface with drug delivery sub-unit and control system.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

(24) An optimal transdermal delivery system, for some applicants, is a topical patch, gel, cream, or similarly applied system that is easily applied by a patient or caregiver onto a convenient, but unobvious location. It will deliver its target drug(s), which may be either small molecules or biologics, with a predictable and programmable rate and absorption kinetics. The system in one form can be designed to deliver drugs for local or regional effect. In other embodiments, the system can be designed to achieve the predictability of an i.v. infusion, but with out the pain and inconvenience of having an installed port. The system should only produce a depot effect by design. In addition, the drug release kinetics should not be interrupted by normal use and should be difficult to intentionally disrupt. The duration and extent of delivery is controlled by a combination of release site, release rate, and surface area. It is an objective to provide controlled delivery from a single day application up to and including 10 days of therapy to accommodate most antibiotic prescription regimes. However, it will be appreciated and understood that the time period for use of the delivery systems described herein varies depending upon the condition to be treated. For example, the devices are intended for use as part of a chronic therapy and therefore, controlled delivery can be achieved for a single day through the end of a person's life depending upon the circumstances and the application. Thus, the time periods and length of treatment recited above is merely exemplary and not limiting.

(25) In accordance with one embodiment of the present invention the above objectives are achieved by an intra-dermal delivery diagnostic and communication system 100 shown in FIGS. 1-4. The system 100 is of the type that includes one or more drug reservoirs or depots and includes a means for delivering the drug to a patient. The system 100 includes at least one drug containing member 110 that stores the drug that is to be delivered. The member 110 includes an actuator 112 that can be in the form of a magnetic membrane that is formed of a magnetic material and a drug containing cell 120 (other actuators can be used, such as a piezoelectric based actuator and therefore, the discussion herein of magnetic membrane 112 is intended to cover one embodiment and is not limiting of the invention since actuator 112 can be another type of actuator). The drug containing cell 120 is flexible but provides the necessary stability to provide a cell that contains the drug that can be in the form of a drug solution or suspension. The drug containing cell 120 thus defines an interior pocket or compartment that contains and stores the drug that is to be delivered. While, the term drug is used herein, it will be understood that other substances besides drugs can be stored in the cell. For example, the cell can contain therapeutic agents, vitamins, etc., and is not limited to a substance that is classified as a drug per applicable government guidelines.

(26) As illustrated in FIG. 1, the magnetic membrane 112 is disposed over the cell 120. The shape and size of the cell 110 can be tailored according to the given application, including the type of drug to be delivered and the quantity that is to be delivered over time.

(27) The drug delivery system 100 also includes a drug delivery device 130 that is complementary to the drug containing member 110 and is designed to mate therewith for controlled delivery of the drug that is contained in the cell 120. For example, the drug delivery device 130 can be in the form of a mechanically robust micro or nano lancet or the like that acts as a carrier portal and cell sealing device. The lancet 130 includes a first end 132 and an opposing second end 134. At the first end 132, the lancet 130 has a magnetic contact 140. The magnetic contact 140 can be in the form of one or more pads or other type of structures. In the illustrated embodiment, the lancet 130 has a support structure 134 (planar surface) that supports the magnetic contact 140.

(28) The lancet 130 also has an elongated hollow body 150 through which the drug is delivered as described below. The hollow body 150 can be an elongated tubular structure (cylindrically shaped tube) that has an inlet 160 (drug entrance or orifice) that is formed between the first and second ends 132, 134 and is located along one side of the hollow body 150. In other words, the hollow body 150 includes a main bore 152 and the inlet 160 is formed perpendicular to the main bore 152. The second end 134 represents an open end of the hollow body 150 and thus represents a distal opening 135 of the main bore 152. The distal opening 135 at end 134 serves as a drug delivering orifice or exit. It will be appreciated that the second end 134 of the lancet 130 is a sharpened end that permits the lancet to pierce an object, such as the skin of the patient. The second end 134 can thus be a sharp, beveled edge.

(29) The lancet 130 also includes a biasing member 170 that is disposed between the hollow body 150 and the support structure 134. The biasing member 170 serves to move the lancet 130 relative to the drug containing member 110 after delivery of the drug from within the cell 120. In the illustrated embodiment, the biasing member 170 is in the form of a spring, such as a leaf spring, that is attached to an underside of the support structure 134 and bows outwardly toward and into contact with the hollow body 150 at a location proximately adjacent to the inlet 160 such that the biasing member 170 does not obstruct drug flow into the inlet 160.

(30) The biasing member 170 will thus store energy when the structure is compressed as shown in FIG. 4 and as described below. In lieu of a biasing element, spaced electromagnets can be energized so as to attract and thereby compress an intervening space, and thereafter energized so as to repel and thereby restore the dimensions of the intervening space, if desired.

(31) According to one embodiment and as shown in FIG. 3, the distance X is approximately equal to the stratum corneum, which is the outermost layer of the epidermis (the outermost layer of the skin). It is composed mostly of dead cells that lack nuclei. The thickness of the stratum corneum varies according to the amount of protection and/or grip required by a region of the body. For example, the hands are typically used to grasp objects, requiring the palms to be covered with a thick stratum corneum. Similarly, the sole of the foot is prone to injury, and so it is protected with a thick stratum corneum layer. In general, the stratum corneum contains 15 to 20 layers of dead cells.

(32) The sequence of using the system 100 to administer one or more drugs to a patient in accordance with one method of the invention can be as follows. First, the proper drug containing member 110 is selected based on the needs of the patient and then it is arranged so that the drug containing cell 120 faces and is placed in contact with a target location of the patient's skin where the drug is to be administered. It will therefore be appreciated that the magnetic membrane 112 faces away from the patient's skin. The drug delivery device 130 is then positioned so that the second end 134 faces the magnetic membrane 112. In other words, the sharp, piercing end of the lancet 130 faces the drug containing member 110 as shown in FIG. 3 which is an illustration of the system just prior to administration of the drug to the patient.

(33) Next, the magnetic elements, namely the magnetic membrane 112 and the magnetic contact 140 are energized using conventional techniques. For example, a microprocessor can include a circuit that is used to energize the magnetic membrane or other electric components (e.g., capacitors) can be used to energize the two magnetic elements. The energized magnetic elements 112, 140 close the gap therebetween resulting in the sharp second end 134 of the lancet 130 piercing first the magnetic membrane 112 and then piercing through both the top surface and the bottom surface of the cell or membrane 120. The magnetic elements 112, 140 are in contact with one another as shown in FIG. 4 and the second end 134 of the lancet 130 is located well below the bottom surface of the cell 120.

(34) At least one of the magnetic elements is an electromagnet; the other can be a permanent magnet or permanent magnet layer. The magnet system is energized when there are two electromagnets that are being driven by an energizing signal, or when there is one electromagnet being driven by an energizing signal in proximity to a permanent magnet.

(35) The construction of the lancet 130 permits the drug within the cell 120 to be delivered therethrough to the patient and more specifically, the dimensions of the lancet 130 and the cell 120 are selected so that when the magnetic elements 112, 140 are in contact with one another (FIG. 4), the drug inlet 160 is located within the cell 120 itself, thereby allows the drug contained therein to flow through the inlet 160 and into the main bore 152. The drug then flows along the arrows shown in FIG. 4 and flows from the inlet 160 down the main bore 152 toward and out of the outlet at the second end 134 and into the patient. As mentioned above, the length of the lancet 130 is selected so that the second end 134 is at a desired penetration depth.

(36) Accordingly, the pressure from the lancet 130 on the drug containing member 110 forces the drug in the cell 120 to flow into the main bore 152 and into the target tissue.

(37) Also, as the lancet 130 pierces the drug containing member 110, the biasing member 170, if provided, compresses and stores energy.

(38) At least one of the magnetic elements 112, 140 can de-energize to allow the lancet 130 to be free and move relative to the drug containing member 110 and also to allow the biasing member 170 to release its energy and return to a relaxed state. This action results in the lancet 130 being withdrawn from the stratum corneum.

(39) It will also be appreciated that the magnetic elements 110, 140 can be energized multiple times, e.g., in succession, and this will result in a pumping action to ensure that an optimal amount of the drug in the cell 120 is delivered to into the patient's skin.

(40) The entire system 100 includes both macro and micro scale components. For example, the component of the system that is disposed within the body is constructed on a micro/nano scale so as to deliver the drug to the patient in an unobvious manner; however, in some embodiments, the structure in which the microscale components are incorporated, such as a path, are on a macroscale. When the system 100 is incorporated into a transdermal patch or the like, the means of adhering the system to the skin must be hypo-allergenic and substantially robust enough to withstand normal daily function including hygiene practice, athletic participation, sleeping, etc.

(41) FIG. 5 shows an intra-dermal drug delivery system 200 according to another embodiment. The system 200 is similar to the system 100 in that it utilizes a similar lancet design to create a micro/nano implant that is delivered into the patient. In this embodiment, the system 200 includes an implant device 210 that includes a support structure having a base 212 at a first end 214 and an elongated holding post 216 that extends outwardly from an underside of the base 212. The base 212 can be in the form of a planar surface, with the holding post 216 being oriented perpendicular thereto. An implant device 210 is broadly speaking any type of device that can be implanted into a patient (e.g., a member that enables intra-dermal installation).

(42) The system 200 also includes a magnetic element 220 which can be in the form of a magnetic strip that is coupled to the base 212. For example, the magnetic element can be a thin planar layer of magnetic material that seats on and is coupled to an upper surface of the base 212. The magnetic element 220 thus represents one end of the implant device 210.

(43) Similar to the system 100, the implant device 210 can include a biasing member 170. In the illustrated embodiment, the biasing member 170 is in the form of a spring, such as a leaf spring, that is attached to an underside of the base 212 and bows outwardly toward and into contact with the holding post 216. Alternatively, a magnetic system arrangement can be used as described above to compress and restore dimensions of the system 200 before and after the implant is deposited in the skin.

(44) The system 200 also includes a drug carrying component 230 which in this case is in the form of micro/nano implant body with a barbed structure 232. As illustrated in FIG. 5, implant body 230 is coupled to a second end 215 of the holding post 216. The implant body 230 has one or more barbs 232 and terminates in a sharp end 234 that is intended to pierce the patient's skin.

(45) The system 200 further includes a magnetic membrane 240 that is intended for placement on the patient's skin. The magnetic membrane 240 can thus be a planar magnetic layer (strip) that can lie against the patient's skin at a target location where the drug is to be administered. In order to hold the magnetic membrane 240 in position on the patient's skin, the magnetic membrane 240 can includes an adhesive or the like, such as an adhesive border that serves to temporarily attach the magnetic membrane 240 to the skin.

(46) It will be appreciated that in this design, the implant 230 is the member that carries the drug that is to be administered into the patient's body. The implant 230, including the barbs 232 can be formed of a number of different material, including a polymer matrix with biodegradable properties. In addition, the implant 230 should be imperceptible when in place and non hypo-allergenic and have a predictable disintegration where the disintegration rate controls the drug release rate since the drug is incorporated into the implant material. Alternatively, the implant 230 can be formed of a resorbable polymer matrix where the release rate is independent of resorption rate and resorption occurs after delivery of the drug content.

(47) The system 200 is operated in the following manner to delivery the drug to the patient. First, the magnetic membrane 240 is placed on the patient's skin and the implant device 210 is positioned as shown in FIG. 5 with the implant 230 facing the magnetic membrane 240. The magnetic element 220 and the magnetic membrane 240 are energized to cause the magnetic elements 220, 240 to close the gap therebetween causing the device 210, including the holding post 216 and implant body 230, to penetrate the stratum corneum painlessly. The biasing member 170 compresses and stores energy.

(48) When the magnetic elements 220, 240 are adjacent one another, the implant 230 has been delivered to the desired penetration depth. The magnetic elements 220, 240 are de-energized releasing the implant device 210 and allowing the biasing member 170 to release its stored energy and return to its relaxed position, thereby withdrawing the base 212 and holding post 216 from the stratum corneum. Upon this withdrawal action, the barbs 232 of the implant body 230 engages the skin layer resulting in only the holding post 216 to be withdrawn from the patient. This results in the implant body 230 being left behind at the desired location and at the desired depth. The dimensions of the implant body 230 and the dimensions and locations of the barbs 232 are selected to accomplish this and result in the implant body 230 and the drug therein to be left at the proper location within the patient's body.

(49) FIG. 6 shows yet another embodiment for the barbed implant body and more specifically, an implant body 300 is shown for use with the system 200. The implant body 300 is similar to implant body 230 in that includes barbs 302; however, in this embodiment, the implant body 300 has a drug containing reservoir 310 formed therein. The reservoir 310 can be simply a bore formed therein that is open only at a first (top) end 304 of the implant body 300.

(50) The implant body 300 and barbs 302 are fabricated out of a bioresorbable material that is formed to include the reservoir 310 that contains liquid, semi-solid or solid drug containing materials. The reservoir 310 is sealed with a sealing membrane 320 that extends across the open end 304 of the body 300 to seal the drug in place. The sealing membrane 320 can be formed of a material that penetrates or dissolves.

(51) The release rate of the drug is controlled by the dissolution rate of payload (small or large molecules) and the surface area of the reservoir opening, as well as post membrane disruption/disintegration.

(52) FIG. 7 shows an implant body 330 that is formed of a solid or porous matrix and includes a holding post cavity (bore) 332 for receiving the holding post 216 (FIG. 5). The release rate is controlled by disintegration/dissolution of the matrix in interstitial fluids.

(53) The shape of the barb in any of the above embodiments can be anything that allows for imperceptible penetration and a sufficient rear side surface to prevent the barb from backing out of the skin.

(54) FIG. 8 shows another embodiment in which an implant body 340 has a drug containing reservoir 350 formed therein. The reservoir 350 can be simply a bore formed therein that is open at both a first (top) end 352 of the implant body 340 and at or near a second end 354 of the implant body 340. The reservoir 350 is sealed with a first sealing membrane 360 that extends across the open first end 352 of the body 300 and with a second sealing membrane 362 that extends across the open second end 354 to seal the drug in place within the reservoir 350. The sealing membranes 360, 362 can be formed of a material that penetrates or dissolves.

(55) FIG. 9 illustrates a drug delivery system 400 that is in the form of an array of a plurality of drug delivery devices 410 that can be fired/triggered based on a prescribed time or response signal. For example, the system 400 can be linked to an energy source 420 that includes a time sequenced firing mechanism. In other words, each of the individual drug delivery devices 410 is linked to the energy source 420 and a controller (microprocessor) can be programmed depending upon the patient's needs to sequentially fire a prescribed number of the drug delivery devices 410 over a period of time to delivery the drug at set time intervals and over the period of time. It will also be appreciated that the array can include more than one drug in that some of the drug delivery devices 410 thereof can contain one drug, while others contain other drugs. By linking each drug delivery device 410 to the energy source, different drugs can be delivered at different times and in proper sequence relative to one another.

(56) It will be appreciated that the drug delivery devices 410 can be one of the systems previously described herein. For example, the drug delivery devices 410 can be of a lancet structure (FIGS. 1-4) or a barbed implant structure (FIG. 5-7). FIG. 10 shows the array being formed of a lancet structure.

(57) In yet another embodiment illustrated in FIG. 11, any of the previous embodiments, including the array 400 can be linked to a biofeedback system 500 that includes a microprocessor, a programmable input, etc. to control delivery of the drug(s) in the array 400. The biofeedback system 500 includes at least one sensor 510 that is in communication with the biofeedback system 500. During biofeedback, special sensors 510 are placed on or in the body and may be incorporated in the lancet structure 130 or the holding post 216. These sensors 510 measure the clinically relevant materials that may be used to detect, diagnosis, monitor or demonstrate control over bodily function or surrogates thereof that is causing the patient's problem symptoms, such as heart rate, blood pressure, muscle tension (EMG or electromyographic feedback), brain waves (EEC or electroencophalographic feedback), respiration, and body temperature (thermal feedback), etc. and delivers the information to the biofeedback system 500 where it is translated and can be displayed as a visual and/or audible readout. Optionally, the biofeedback sensor can be part of the transdermal drug delivery systems 100, 200, 300, 400 that have been described hereinbefore or it can be one of the delivery systems described hereinafter.

(58) The biofeedback system 500 is in communication with a controller 520 that is linked to each of the drug delivery devices 410 of the array 400 and is configured to actuate (energize) each of the drug delivery devices 410 at a specific point in time or to actuate only a portion of the drug delivery devices 410 rather than all of them as a function of the person's requirements relative to a target value using the biofeedback information. As described above, this allows for controlled release of drug to the patient and since it is part of a biofeedback system, the information detected by the sensors 510 is used to decide when and how to trigger release of the drug. For example, if the sensor 510 is measuring a property of the patient's blood, and the measured values fall outside of an acceptable range, the sensor 510 will send a signal to the biofeedback system 500 which in turn signals the control system 520 to actuate one or more devices 410 that contain the specific drug(s) that is to be administered to correct and combat the detected condition. The information from the biofeedback system 500 may also be sent to the control system 520 where it may be stored in memory 531 and/or displayed 530 or transmitted for display immediately or in an appropriate time and manner to patient and or others, including physicians and/or mange care organizations, to demonstrate effectiveness and or progress of therapy. Memory 531 can be internal memory that is associated with the master controller 520 or it can external memory that is located remote from the inter-dermal delivery device and is accessed using the communication network described below.

(59) A communication subsystem 537 is provided for communicating information from the controller 520 to another device, such as an external device (e.g., handheld unit or a computer that is connected over a network to the communication subsystem 537). The means for sending information (communication subsystem 537) can include use of a radio frequency transmitter or other appropriate mechanism.

(60) An external device 539 (ubiquitous device) is in communication with the subsystem 537 to allow information and control signals to flow between the intra-dermal device (e.g., the subsystem 537 thereof) and the external device 539. The external device 539 thus includes a receiver which can be incorporated or may be a standalone device such as a handheld device, e.g., a cellular phone, a Personal Digital Assistant (PDA), a media player (e.g., an I-POD) or similar electronic device that contains its own energy source, a CPU, and interface software. In other words, the means for sending information can be provided in a handheld unit that has a receiver and it can be provided either be a unit that is dedicated to performing the function described herein or it can be supplied as part of and a feature of another device, such as a cellular phone. Alternatively the receiver 539 may be a part of common communication infrastructure services, such as WiFi, WiMax, cellular communication towers, etc. It will be understood that the interface should include signal transmission that is appropriate to Health Maintenance Organizations, Insurance Companies, and or Managed Care companies, as well as patients and physicians already described. In this manner, information can be readily transmitted from the intra-dermal delivery device to a person at a remote location via the use of external communications devices. A physician or the like can thus monitor, over an external device 539, the measurements (bio-properties) taken at the intra-dermal delivery device and since the external device 539 communicates with the intra-dermal delivery device, the physician can send control signals to the controller 520 to cause immediate release of drug or the like.

(61) Once again, it will be understood that the present device has both macro and micro/nano sized features and in particular, the features (e.g., microneedles, barbs, etc. as disclosed herein) that are moved into the intra-dermal space are micro/nano sized, while the structure (e.g., a patch or casing as disclosed herein) that supports these are on a macro-scale since this placed on the user's skin.

(62) A power source or energy subsystem 541, such as a battery, is provided for powering the microcontroller 520 and any other electronic components that may need powering. A charger or other means for energy delivery 543 for charging power source 541 or otherwise powering the energy subsystem 541 is provided.

(63) It will also be appreciated that the array of drug delivery devices 410 can be part of a cartridge-based delivery system in which an applicator is used. The applicator includes a compartment that removably receives the array cartridge and properly positions the drug delivery devices 410 relative to the electronics of the applicator. The electronics, including a controller, communication subsystem(s) and the energy subsystems, can be part of a permanent interface device that is adjacent the compartment that receives the cartridge (as by inserting the cartridge through a slot). The user thus simply inserts the cartridge into the applicator and this results in proper alignment with the firing mechanism that causes the implants to be selectively and controllably delivered to the patient since the controller of the applicator (microprocessor) can be programmed depending upon the patient's needs to sequentially fire a prescribed number of the drug delivery devices 410 over a period of time to delivery the drug at set time intervals and over the period of time. The patient can simply insert a fresh array cartridge once a day/week/month, etc.

(64) FIG. 12 illustrates a transdermal delivery system 600 according to yet another embodiment. The system 600 includes a micro/nano removable barb assembly 610 and a protective gel layer 620. In particular, the assembly 610 includes a plurality of barbs 612 (can be arranged as an array) that extend from a flexible substrate 614 and contain a sharp, pointed end 616. The barbs 612 protrude from the substrate 614 and can be oriented perpendicular thereto. The protective gel layer 620 is disposed opposite the substrate 614 in that the protective gel layer 620 is located along the pointed ends 616 of the barbs 612.

(65) The barb configuration operates in the same manner as the barb configurations described above in that the drug to be delivered is incorporated into the barb (implant) structure. However, in this embodiment, the implant force comes from manually applying pressure to the top surface of the flexible substrate 614 or via pressure applied by an applicator. The protective gel layer 620 provides: a stable protective environment for the micro/nano structures; a pleasant skin contact surface and potentially the ability to incorporate a local anesthetic agent/antimicrobial agent to provide a benefit during barb insertion.

(66) When a force is applied to the top plane of the flexible substrate 614, the micro/nano sized barb structures 612 penetrate through the protective gel layer 620 and pierce/enter the skin to the desired depth. The dimensions of the barbs 612 are thus selected so that the barbs 612 are delivered to the desired location underneath the patient's skin. Once the force being applied to the substrate 614 is removed, the barbs 612 disengage from the holding posts 216 and remain in the desired location for dissolution/disintegration/resorption per application design for a given treatment.

(67) The flexible substrate 614 can be formed of any number of different materials and can have any number of different constructions. For example, the flexible substrate 614 can be form of a pliable material that can be comprised of a plurality of functional layers, including an chemically inert barb protective layer, an anesthetic layer and an adhesive layer, where the layers may be separate an distinct from each other or where they may be formulated in combination. The skin contact layer including a topical anesthetic, which may be from but not limited to (benzocaine, butamben, dibucaine, lidocaine, oxybuprocaine, pramoxine, proparacaine (Alcaine), proxymetacaine, and tetracaine (AKA amethocaine). The anesthetic is incorporated in a gel layer which may be comprised of cross-linked polymers or other materials, preferably something inert such as silica. The gel layer may have adhesion properties to ensure proper surface to skin contact and also allow for pain free removal as required.

(68) This type of system 600 can be used for drug or cosmetic applications.

(69) FIG. 13 illustrates an applicator 700 that can be used in combination with the system 600. The applicator 700 has a body 710 that contains an interior compartment 720 that includes a first supply section 722 and a second section 724. The interior compartment 720 stores a feedstock of drug delivery devices that contain the drug(s) to be delivered. For example, a roll of the micro/nano removable barb assembly 610 and protective gel layer 620 can be disposed about a spindle or gear 726 that permits unwinding of the barb/gel assembly. The body 710 can include one or more guide members 730 that serve to route the barb/gel assembly through the interior compartment 720 as it is unwound.

(70) Along one surface 712 of the body 710, an applicator window 730 is formed for delivering the drug containing structures (barb/gel) to the patient. The roll of barbs/gel is routed so that it passes adjacent the window 730 such that the gel layer 620 faces the window and the pointed ends of the barbs face the window 730 to permit them to be implanted into the patient. To implant the barbs 612 into the patient, the applicator can be actuated to cause a force to be applied to the substrate 614 to cause the barbs 612 to be advanced through the window 730 and into the patient's skin as described above.

(71) After implanting a predetermined number of barbs 612 (e.g., the ones visible through the window 730), the applicator 700 is manipulated to cause the roll to be advanced and the spent micro/nano barbs 612 are taken up on a spindle or gear 740. For example, the applicator 700 can include a knob that causes advancement of the feedstock of barbs when it is rotated. Other mechanism can equally be used. The barbs 612 and gel layer 620 can be routed in the body 710 such that it is fed to the window 730 in a manner that causes the barbs 612 and gel layer 620 to protrude beyond the surface 712 and thus when the applicator 700 is pressed against the skin to position surface 712, into contact with the skin, the barbs 612 are implanted. Alternatively, the applicator can have some type of firing mechanism that applies a force to the substrate 614 to cause the barbs 612 to be implanted.

(72) It will also be appreciated that the roll of the micro/nano removable barb assembly 610 and protective gel layer 620 can be part of a cartridge and thus, the applicator 700 can be a cartridge based system. Electronics, including controllers, etc., of the applicator 700 are located on a more permanent interface device. The patient simply inserts a fresh array cartridge once a day/week/month, etc.

Example

(73) One application for a drug delivery system is the human ear. More specifically, the barbed implant design of FIGS. 5-7 can be configured as an anti-infective implant formulation for use prophylactically or as a curative agent in middle ear infections. The barbed implants are coupled to a topical application (e.g., similar to a swab (Qtip) or a film) and the barbed-based formulation is applied to the outer surface of the eardrum allowing the micro/nano barbs to penetrate the membrane and enter the region of the middle ear where the barbs with anti-infective agents (antibiotics) are deposited to pre-condition or treat an already infected ear space. The applicator may take the form of a gel, or multi-layer film which could include a topical anesthetic to facilitate application to areas where nerves have been sensitized.

Example

(74) Another example is for the barbed implant design of FIGS. 5-7 can be configured as an anti-infective or anti-allergic implant formulation for use prophylactically or as a curative agent in nasal infections or rhinitis. The barbed implants are coupled to a topical application (e.g., similar to a swab (Qtip) or a film, or spray) and the barbed-based formulation is applied to the nasal mucosa allowing the micro/nano barbs to penetrate the membrane and enter the region of the middle ear where the barbs with anti-infective agents (antibiotics), anti-allergic agents (anti-histamines, etc.) are deposited to pre-condition or treat an already effected nasal space. The applicator may take the form of a gel, spray or multi-layer film which could include a topical anesthetic to facilitate application to areas where nerves have been sensitized.

Example

(75) Another application is for a tumor/organ wrap that is configured to directly infuse sustained release agents. The wrap is formed of a fabric or shrinking polymer skin to drive barb open portals and allow for active transfer of agent to the target tissue. The wrap can be applied laproscopically by spray or roll on.

(76) In yet another embodiment, the transdermal delivery systems disclosed above can be part of a system that provides a visual indicator to the person using the system that the application of drug was or was not successful. For example, the applicator and the barbs can be constructed so that a color change occurs on release (implant) of the barb into the patient's skin, thereby providing a visual indicator or confirmation that a successful delivery resulted. In other words, when the barbs are removed from the holding posts or other supporting structure, a color change results. This could occur by having the distal tip of the holding post be formed of a material that upon discharge of the surrounding barbed implant and upon exposure to air, changes color. Alternatively, the end of the holding post may have a color that is initially covered up by the barbed implant but upon implanting the barbed implant into the patient, the color is exposed.

(77) The user of such a system will thus be able to readily determine how many barbed implants were successfully delivered into the patient. For example, when the barbed implant are located at the end of a swab, after the swab is pressed against the patient's skin, it will readily be apparent what areas of the swab successfully delivered their barbed implants by simply looking at the surface of the swab. The user will see regions of no color (or a first color) indicated implants still intact and regions of another color indicated successful implantation.

(78) Yet another delivery system application includes systems as described hereinabove in which a substance is delivered locally and below the stratum corneum and has a composition that swells after implantation so as to apply pressure to the stratum corneum from below the surface. One application of such a topical application is to reduce the appearance of wrinkles or to tighten the surface of skin.

(79) For example, the barbed implant disclosed herein can be part of a cosmetic wrinkle reduction system. The system enables anyone desiring to reduce or temporarily eliminate facial wrinkles (around the mouth, nose, eyes, etc.) typically associated with aging by easily and painlessly implanting an appropriate amount of swelling barbed implants between the stratum corneum and the stratum germinativum where interstitial fluids will cause the barbs to expand and apply appropriate pressures to the stratum corneum to fill in the valleys that cause wrinkles. The barbed implants may be formed from materials that are endogenous in the body and that can be complexed to form swelling hydro-gel type matrix. As with the other embodiments, the barbed implants will be absorbed and eliminated without potential accumulation.

(80) Now referring to FIGS. 14-22 in which other embodiments are illustrated. In FIG. 14, a device 800 that is part of a micro/nano transdermal delivery system and includes at least one and preferably a plurality of microneedles 810 with channels 820 formed therein. The microneedle(s) is mounted on an oscillating movable base 830. The device 800 includes a fixed casing 802 that is open along a bottom 804 thereof. In the illustrated embodiment, the fixed casing 802 has a top portion 804 that closes off the fixed casing 802. The movable base 830 is located proximate the top portion 804 and extends across side walls 805 of the casing 802.

(81) The contact between a surface of the device (e.g., a bottom surface 807) and the skin is managed by and at the same time limited by the fixed casing 802. The microneedles 810 are oscillated at a frequency between about 0 kHz to about 3 MHz (preferably between about 5 kHz to about 2 MHz), with amplitudes of between about 0 to about 1000 microns (preferably between about 5 microns to about 250 microns) as a result of the base 830 being movable. Amplitudes of oscillations are varied for drilling/opening channels in the stratum corneum/epidermis/dermis and/or pumping/suction of drug/blood/interstitial fluids. The oscillating microneedles 810 (with respect to the fixed device casing 802) create holes with specified properties in the stratum corneum. The design of the microneedles 810 varies for specific requirements and depending upon the particular application. The creation of the back pressure and/or the interface pressure between the stratum corneum and the device 800 interface pressure drive the drug to the target level in the intra-dermal space.

(82) FIG. 14 shows a basic device 800 for both delivery of a drug and extraction of a fluid, such as blood and/or interstitial fluid. FIG. 14 shows the device 800 in a normal rest position where the microneedles 810 are not extended into an out-of plane delivery or extraction position. FIG. 15 shows the device 800 in an activated condition where the base 830 has oscillated relative to its position in FIG. 14 and this results in the microneedles 810 being moved out of the plane such that the distal tips 812 of the microneedles 810 extend below the bottom surface 807 of the device 800 (casing 802). FIGS. 14 and 15 show two channels 820 being formed therein. The channels 820 can have the same construction or they can contain different constructions as shown. FIG. 15 thus shows an out-of-plane oscillation where the distal tip 812 advances into the skin to the desired depth as described herein.

(83) In FIG. 15, each of the channels 820 includes a flow control device 850, 852 (such as directional valves/pumps) that are included in the respective channels 820 to control flow within the channel 820 to be controlled. The flow control component 850, 852 is in communication with the master controller/processor of the device 800 to allow control thereof depending upon the precise application and state of the microneedle 810. Additional flow control devices can be provided in the device in locations remote from the actual channels to control flow of fluid within the device.

(84) FIG. 16 shows a device 900 that includes a number of different types of microneedle constructions and in particular, channel constructions. It will be understood that the device 900 that is shown can include one type of microneedle construction or it can include a combination of different types of microneedle constructions. For example, FIG. 16A shows a microneedle 810 that has a passive free-flow channel construction. In particular, the microneedle 810 includes a single channel 820 that has a main section 822 that is open at the top and bottom of the microneedle 810 and includes a side or secondary section 824 that is open along the side of the microneedle 810 prior to the distal tip 812. Fluid flows freely in both directions within the channels. FIG. 16B shows a microneedle 810 of a different construction where there is a single channel 820 with flow control. In particular, the single channel 820 is similar to the channel shown in FIG. 16A in the channel 820 that has a main section 822 that is open at the top and bottom of the microneedle 810 and includes a side or secondary section 824 that is open along the side of the microneedle 810 prior to the distal tip 812. At or near the top end of the main section 822, a directional valve/pump 850 is included to control flow within the channel 820 to be controlled. The flow control component 850 is in communication with the master controller/processor of the device 800 to allow control thereof depending upon the precise application and state of the microneedle 810.

(85) FIG. 16C shows a microneedle 810 that is similar to those in FIGS. 16A and 16B; however, in this embodiment, the microneedle 810 has a multi-channel construction. More specifically, the microneedle 810 includes a first channel 820 and second channel 821. The first channel 820 is open at the top end and is open at the distal end. The second channel 821 is open at the top end and opens along the side of the microneedle 810. At or near the top end of both the first section 820 and the second channel 821, directional valves/pumps 850, 852 are included in the respective channels to control flow within the channel 820, 821 to be controlled. The flow control component 850 is in communication with the master controller/processor of the device 800 to allow control thereof depending upon the precise application and state of the microneedle 810.

(86) FIG. 16D shows a microneedle 810 that includes a back pressure channel. More specifically, the microneedle 810 includes a main channel 815 that has a top end and a bottom end that is open at the distal end of the microneedle 810. A side or back channel 831 is provided in the microneedle 810 such that one end of the side channel 831 is open along the side of the microneedle 810 and the other end communicates with the main channel 815. At a location above the juncture between the side channel 831 and the main channel 815, a directional valve/pump 850 is included in the respective channels to control flow within the channel to be controlled. The flow control component 850 is in communication with the master controller/processor of the device 800 to allow control thereof depending upon the precise application and state of the microneedle 810. The arrows shown in FIG. 16D reflect fluid flow.

(87) FIG. 17 shows the backpressure microneedle embodiment of FIG. 16D installed in a device for use in a micro/nano transdermal delivery system. In FIG. 18, there are two flow control components 850 that allow control over the fluid as it flows within the device, such as when the drug to be delivered flows into the microneedle 810. In FIG. 17, the microneedle 810 is in a normal, rest position where the distal tip of the microneedle 810 does not extend beyond the bottom of the device (casing). FIG. 18 shows the microneedle 810 in an actuated state (oscillated out-of-plane) where the microneedle 810 extends beyond the casing resulting in the distal tip of the microneedle 810 being driven into the skin.

(88) FIG. 19 shows a sub-unit 1000 constructed in accordance with the present invention. The unit 1000 includes a body 1010 that has a drug containing reservoir 1020 that is contained between a pair of substrates or layers 1022. The layers 1022 can be in the form of an actuator that is configured to selectively fire one or more microneedles 810. For example, the layers 1022 can be formed of piezoelectric strips that, as is known, change shape when powered by small amounts of electricity. The layers 1022 can be other types of actuators, such as a pressure actuator and/or motion actuator, which under select conditions, causes deformation of the unit 1000 in a manner described below resulting in controlled release of the drug contained in the reservoir 1020.

(89) The unit 1000 includes at least one and preferably a plurality of microneedles 810 that are in selective communication with the reservoir 1020. The precise structure and interface between the reservoir 1020 and the microneedles 810 can vary depending upon the particular application and other considerations. For example, there can be a main channel 1030 that is in selective communication with the reservoir since a valve/pump 1040 is provided within or at the end of the main channel 1030 to control flow of the drug from the reservoir 1020. The main channel 1030 is also in communication with an internal channel network that delivers the fluid from the reservoir to a number of channels that directly feed the microneedles 810 and allow the drug to be discharged through the distal tips of the microneedles 810.

(90) The unit 1000 further includes biofeedback system 500 that is in communication with a controller 520 that is linked to each of the drug delivery devices (microneedles 810 in this case) of the array and is configured to actuate (energize) each of the microneedles 810 at a specific point in time or to actuate only a portion of the microneedles 810 rather than all of them as a function of the person's requirements relative to a target value using the biofeedback information. As described above, this allows for controlled release of drug to the patient and since it is part of a biofeedback system, information detected by the sensors 510 is used to decide when and how to trigger release of the drug. For example, if the sensor 510 is measuring a property of the patient's blood, and the measured values fall outside of an acceptable range, the sensor 510 will send a signal to the biofeedback system 500 which in turn signals the control system 520 to actuate one or more microneedles 810 that contain the specific drug(s) that is to be administered to correct and combat the detected condition.

(91) The information from the biofeedback system 500 may also be sent to the control system where it may be stored and or displayed 530 or transmitted for display immediately or in an appropriate time and manner to patient and or others, including physicians, to demonstrate effectiveness and or progress of therapy. The means for sending information may include use of radio frequency transmitter or other appropriate mechanism, generally shown as communication subsystem 505 in FIG. 19. As previously mentioned, the receiver can be incorportated or may be a standalone device such as a handheld device, e.g., a cellular phone, a Personal Digital Assistant (PDA), a media player (e.g., an I-POD) or similar electronic device that contains its own energy source, a CPU, and interface software. In other words, the means for sending information can be provided in a handheld unit that has a receiver and it can be provided either be a unit that is dedicated to performing the function described herein or it can be supplied as part of and a feature of another device, such as a cellular phone. Alternatively the receiver may be a part of common communication infrastructure services, such as WiFi, WiMax, cellular communication towers, etc. It will be understood that the interface should include signal transmission that is appropriate to Health Maintenance Organizations, Insurance Companies, and or Managed Care companies, as well as patients and physicians already described.

(92) It will also be appreciated that the biofeedback system 500 disclosed herein is not limited to being used as a part of a larger drug delivery device or in combination therewith. Instead, all of the drug delivery devices disclosed herein can be modified so as to not include the drug delivery component (e.g., reservoir) or if this component is present, the communication from the feedback system 400 to the control system can be for diagnostic purposes only and not related to signals or instructions relating to release of drug. In other words, the biofeedback system can communicate with the control system which can store and/or display the received information irrespective of drug delivery.

(93) Now referring to FIG. 20 in which another sub-unit 1100 is shown. The sub-unit 1100 includes the fixed casing 802 that houses the drug containing reservoir 110, the microneedles 810 and the other components. In the illustrated embodiment, the reservoir 110 is in communication with at least one actuator. For example, one or more pressure actuators 1110 can be provided for applying a select force to a local area of the unit. In the illustrated embodiment, the pressure actuators 1110 are located along the top of the reservoir 110. In addition, one or more motion actuators 1120 can be provided and in the illustrated embodiment, a plurality of motion actuators 1120 are located along the bottom of the reservoir 110 and are spaced apart from one another. The motion actuators 1120 are located so as not to obstruct the flow of the drug from the reservoir 110 into the top of the main channel 821 in the microneedle 810. The combination of these actuators provides a means for actuating select microneedles 810 to cause advancement (firing) of the microneedle 810 into the skin of the patient and to permit the microneedles to resume their normal retracted, rest positions.

(94) As with the other embodiments, one or more valves/pumps 1130 can be provided for controlling the flow of fluid within the device. For example, one valve/pump 1130 can be provided in a line that communicates between the reservoir 110 and sensor 510 and one or more valves/pumps 1130 can be provided between the reservoir 110 and the channel architecture. As with other embodiments, the microneedles 810 can be extended beyond the casing and into the skin.

(95) FIG. 21 shows another sub-unit 1200. This embodiment is similar to the other embodiments; however, in this embodiment, there are piezoelectric strips 1210 located along both the top and bottom of the reservoir 110. The strips 1210 thus define the interior of the reservoir 110. Actuation of the piezoelectric strips 1210 causes selective firing (deformation) of certain microneedles 810.

(96) FIG. 22 discloses an alternate micro/nano drug delivery device 1300 depicting biosensor interface with drug delivery sub-unit and control system. The device 1300 includes the sub-unit 1200 shown in FIG. 21 and further includes biofeedback system 500 that is in communication with a controller 520 that is linked to each of the drug delivery devices (microneedles 810 in this case) of the array and is configured to actuate (energize) each of the microneedles 810 at a specific point in time or to actuate only a portion of the microneedles 810 rather than all of them as a function of the person's requirements relative to a target value using the biofeedback information. As described above, this allows for controlled release of drug to the patient and since it is part of a biofeedback system, information detected by the sensors 510 is used to decide when and how to trigger release of the drug. For example, if the sensor 510 is measuring a property of the patient's blood, and the measured values fall outside of an acceptable range, the sensor 510 will send a signal to the biofeedback system 500 which in turn signals the control system 520 to actuate one or more microneedles 810 that contain the specific drug(s) that is to be administered to correct and combat the detected condition.

(97) In the illustrated embodiment, the sensor 510 is disposed proximate (adjacent) a reservoir 511 that is in selective communication with the reservoir 110 via a conduit or passage 111. A pump/valve 850 is disposed along the conduit 111 to permit flow between the reservoirs 511, 110. Other pumps/valves 850 are disposed in communication with the microneedle channels to selectively allow fluid to flow between reservoir 110 and the microneedles 810. A pressure actuator 1310 is provided and is located in reservoir 511 that is adjacent the sensor 510.

(98) As shown in FIG. 22, the electronic controller 520 is in communication with the working components of the device including the pumps/valves 850, sensor 510, pressure actuator 1310, etc.

(99) The information from the biofeedback system 500 may also be sent to the control system where it may be stored and or displayed or transmitted for display immediately or in an appropriate time and manner to patient and or others, including physicians, to demonstrate effectiveness and or progress of therapy. The means for sending information may include use of radio frequency transmitter or other appropriate mechanism. As previously mentioned, the receiver can be incorportated or may be a standalone device such as a handheld device.

(100) The devices of FIGS. 14-22 are configured to perform any number of different operations. For example, in one embodiment, a negative back pressure (difference) is utilized to extract blood and/or interstitial fluid from the intra-dermal region into the appropriate reservoir(s) (e.g., 511 in FIG. 22) and in contact with a sensor(s) 510. Pressure oscillations and motion control (e.g., using the disclosed actuators, piezoelectric strips, etc.) are utilized to move fluid in and out of the reservoir 511 and in and out of contact with the sensor(s) 510. The pressurized reservoirs utilize a synchronization scheme. Frequency and duty cycles as well as synchronization are optimized for the maximum performance. The biological sample can be obtained using any number of different techniques as described hereinbefore.

(101) Biosensing of the biological material can be accomplished utilizing electrical/electrochemical/mass detection. The system can utilize one or more of i) application of DC voltage and measuring the DC current response (amperometry), ii) application of a DC current and measuring the DC voltage response (potentiometry), or iii) application of an AC voltage and measuring the AC current response (capacitance or impedance). In all cases, three electrodes are incorporated into the intra-dermal delivery, diagnostic and communication device, the working, reference and counter electrodes. These electrodes are positioned as closely together as possible, with analyte detection occurring at the working electrode. Ideally, the electrodes are designed such that the voltage is applied between the working and reference electrodes, while current is detected through the counter electrode. Mass deposition on a functionalized surface can be detected by intertia based methods such as the resonance frequency shift of a cantilever beam due to its change of mass.

Example

(102) The following is a general description of how one of the devices of FIGS. 14-22 can be used as a drug delivery application. In a first step, the back pressure is increased or the back pressure is oscillated out-of-phase with the microneedle motion. This results in the stratum corneum being pecked for a duty cycle (defined by a frequency, amplitude, and duration) and the creation of multiple holes in the stratum corneum. Large drug molecules are forced through the stratum corneum due to the (oscillating) back-pressure motion. In a subsequent step, the pecking motions are stopped and the (static) back-pressure is kept until the holes in stratum corneum are closed/healed.

(103) In accordance with one embodiment, a mode of operation diagnostic includes decreasing the back-pressure (or oscillate the back pressure out-of-phase with the needle motion); peck the stratum corneum for a duty cycle (frequency, amplitude, and duration; thereby creating multiple holes in the stratum corneum. This forces blood/fluid from these holes thorough the stratum corneum due to the (oscillating) negative back-pressure into the sensor(s) reservoir(s) that contains the drug.

(104) The pecking motions are stopped and the back-pressure is increased to the internal body pressure until the holes in stratum corneum are closed/healed. There are a number of advantages that can be realized with the device and method of the present invention, including but not limited to the following: the required contact time with the top of the stratum corneum is very short (micro-seconds since the operation time-scale is short (kHz-MHz)); no need for long contact periods with the top of the stratum corneum since the device can be activated as the contact is established; only a brief period of contact with the stratum corneum is required (i.e., microseconds); large molecules can be delivered through large holes in the stratum corneum (due to the microneedle size); multi-drug delivery is possible due to modular design of reservoirs/sensors and rapid operations; provides time for the stratum corneum to heal due to micro-second operations and hours of usage (off) times; it is minimally invasive; rapid blood/fluids extraction leading to multiply tests/monitors; large number of control parameters (amplitude, frequency, duration, etc.) provides flexibility in device design, operations, and uses; very rapid dosage alterations on-the-fly (as needed) are possible due to short operation times; can be programmed for continuous, patterned, on-demand or feedback-controlled drug delivery/monitoring; novel microneedle designs can be integrated and this provides further flexibility in delivery design and utilization regimes; active process control is possible due to the large number of control parameters; short operation times minimize energy consumption; modular design allows the dispersion of chemical permeation enhancer and the integration of thermal/ultrasonic/electrical enhancing components.

(105) It will be understood that the components, including the sensors and drug delivery devices, shown in FIGS. 14-22 are suitable for use in the system generally illustrated in FIG. 11.

(106) While the invention has been described in connection with certain embodiments thereof, the invention is capable of being practiced in other forms and using other materials and structures. Accordingly, the invention is defined by the recitations in the claims appended hereto and equivalents thereof.