Non explosive bis-sulfonyl azides

Abstract

The invention relates to a compound of the general formula (I) N.sub.3O.sub.2SAr-L-ArSO.sub.2N.sub.3, wherein: Ar and Ar are aromatic building blocks; and L is a linking group comprising at least one heteroatom as well as an organic chain denoted as Sp and having at least two carbon atoms. The invention also relates to a compound of the general formula (II) wherein: Ar and Ar are aromatic building blocks; L is a covalent bond or a linking group; m and n are both 0 or 1, at least one of m and n being 1; Sp and Sp are organic chains having at least two carbon atoms. The invention also relates to the use of these compounds as cross linking agents in the manufacture of polymers.

Claims

1. A compound of the general formula
N.sub.3O.sub.2SAr-L-ArSO.sub.2N.sub.3,(I) wherein: Ar and Ar are each independently a substituted or unsubstituted phenyl group; L is a linking group O-Sp-O; and Sp is an aliphatic group having at least two carbon atoms; not including compounds of the general formula:
N.sub.3O.sub.2S(Ar-z)-R.sub.1-Sp-(R.sub.2(Ar-z)-SO.sub.2N.sub.3).sub.x,(III) wherein: Ar is an aromatic building block; z is a hydrogen atom or a chlorine atom x is superior or equal to 1 R.sub.1 is selected from the group consisting of CONH, NHCO, and CONCH.sub.3; R.sub.2 is selected from the group consisting of CONH, NHCO, and CONCH.sub.3 or CHCH; and Sp is an organic chain with at least one carbon atom or a covalent bond.

2. The compound according to claim 1, wherein Sp is an aliphatic chain having at least 3 carbon atoms.

3. The compound according to claim 1, wherein Ar and Ar are identical phenyl groups.

4. The compound of claim 1, wherein the compound is: 1,6-bis-(4-azidosulfonylphenoxy)-hexane, 1,10-bis-(4-azidosulfonylphenoxy)-decane, 1,2-bis-(4-azidosulfonylphenoxy)-hexadecane, an isomeric mixture of 4,8-bis-(4-azidosulfonylphenoxymethyl)-tricyclo[5.2.1.0.sup.2.6]decane, 1,4-bis-(4-azidosulfonylphenoxymethyl)-cyclohexane, or 1,n-bis-(4-azidosulfonylphenyl)-polyethylene glycol ether.

5. A composition comprising the compound according to claim 1, and containing at most 50% (w/w) of a phlegmatizing agent or is without phlegmatizing agent.

6. A method of cross-linking a substrate, comprising the use of the reacting the substrate with a compound of the general formula
N.sub.3O.sub.2SAr-L-ArSO.sub.2N.sub.3,(I) wherein: Ar and Ar are each independently a substituted or unsubstituted phenyl group; L is a linking group OSpO; and Sp is an aliphatic group having at least two carbon atoms; and not including compounds of the general formula:
N.sub.3O.sub.2S(Ar-z)-R.sub.1-Sp-(R.sub.2(Ar-z)-SO.sub.2N.sub.3).sub.x,(III) wherein: Ar is an aromatic building block; z is a hydrogen atom or a chlorine atom x is superior or equal to 1 R.sub.1 is selected from the group consisting of CONH, NHCO, and CONCH.sub.3 R.sub.2 is selected from the group consisting of CONH, NHCO, and CONCH.sub.3 or CHCH; and Sp is an organic chain with at least one carbon atom or a covalent bond.

7. The method according to claim 6, wherein the compound is selected from the group consisting of: 1,6-bis-(4-azidosulfonylphenoxy)-hexane, 1,10-bis-(4-azidosulfonylphenoxy)-decane, 1,2-bis-(4-azidosulfonylphenoxy)-hexadecane, an isomeric mixture of 4,8-bis-(4-azidosulfonylphenoxymethyl)-tricyclo[5.2.1.0.sup.2.6]decane or 1,4-bis-(4-azidosulfonylphenoxymethyl)-cyclohexane, and 1,n-bis-(4-azidosulfonylphenyl)-polyethylene glycol ether.

8. The method according to claim 6, wherein the reacting step yields a polymer.

9. The method according to claim 6, wherein the reacting step yields polyolefins, polyolefin copolymers, and/or blends of polyolefins.

10. The method according to claim 6, wherein the reacting step yields elastomers, elastomer copolymers, and/or blends of elastomers.

11. The method of claim 7, wherein the reacting step is performed with a composition comprising the compound and at most 50% (w/w) of a phlegmatizing agent or comprising the compound without a phlegmatizing agent.

12. A compound of the general formula:
(N.sub.3O.sub.2SArY).sub.2Sp,(I) wherein Ar is a substituted or unsubstituted phenyl group; Sp is an aliphatic group having at least two carbon atoms; and Y is a functional group selected from the group consisting of O, C(O)O and OC(O).

13. A composition comprising the compound according to claim 12, and containing at most 50% (w/w) of a phlegmatizing agent or is without phlegmatizing agent.

14. A method of cross-linking a substrate, comprising reacting the substrate with the compound of claim 12.

15. The method of claim 14, wherein the reacting step is performed with a composition comprising the compound and at most 50% (w/w) of a phlegmatizing agent or comprising the compound without a phlegmatizing agent.

16. The method of claim 14, wherein the reacting step yields a polymer.

17. The method of claim 14, wherein the reacting step yields polyolefins, polyolefin copolymers, and/or blends of polyolefins.

18. The method of claim 14, wherein the reacting step yields elastomers, elastomer copolymers, and/or blends of elastomers.

Description

BRIEF DESCRIPTION OF THE FIGURES

(1) FIG. 1 shows the evolution of complex viscosity (Y-axis, in Pa.Math.s) over the frequency (X-axis, in rad/s) of POHOP-SA in HDPE.

(2) FIG. 2 shows the evolution of storage and loss modulus (Y-axis, in Pa) over the frequency (X-axis, in rad/s) for various molarity of POHOP-SA in HDPE; more particularly 0.329 mmol/kg and 0.657 mmol/kg of POHOP-SA in HDPE.

(3) FIG. 3 shows the evolution of storage and loss modulus (Y-axis, in Pa) over the frequency (X-axis, in rad/s) for 2.629 mmol/kg of POHOP-SA in HDPE.

(4) FIG. 4 shows the evolution of storage and loss modulus (Y-axis, in Pa) over the frequency (X-axis, in rad/s) for 2.629 mmol/kg of POHOP-SA in HDPE.

(5) FIG. 5 shows the evolution of storage and loss modulus (Y-axis, in Pa) over the frequency (X-axis, in rad/s) for various molarity of PODOP-SA in HDPE; more particularly 0.329 mmol/kg and 0.657 mmol/kg of POHOP-SA in HDPE.

(6) FIG. 6 shows the evolution of storage and loss modulus (Y-axis, in Pa) over the frequency (X-axis, in rad/s) for 2.629 mmol/kg of PODOP-SA in HDPE.

(7) FIG. 7 shows the evolution of complex viscosity (Y-axis, in Pa.Math.s) over the frequency (X-axis, in rad/s) of PODOP-SA and DPO-BSA.

(8) FIG. 8 shows the evolution of storage and loss modulus (Y-axis, in Pa) over the frequency (X-axis, in rad/s) for 2.629 mmol/kg of PODOP-SA and 2.629 mmol/kg of DPO-BSA.

DETAILED DESCRIPTION

(9) The invention will now be described in more detail without limitation in the following description.

(10) The compounds of the invention fall into two categories, namely type 1 and type 2.

(11) Compounds of the invention of type 1 have following general formula:
N.sub.3O.sub.2SAr-L-ArSO.sub.2N.sub.3.(I)

(12) Compounds of the invention of type 2 have following general formula:

(13) ##STR00006##

(14) In the above formulas, Ar and Ar are aromatic building blocks.

(15) The aromatic building blocks Ar and Ar are aryl moieties, i.e. they are or they comprise respective aromatic rings. These aromatic rings can be substituted or not. In case substituents are present, they can in particular be similar to the side chains Sp and Sp which are described in more detail below. In this case, the aromatic ring of the Ar/Ar aromatic building block can be linked to more than one side chain Sp/Sp, for instance to two side chains Sp/Sp, or to three side chains Sp/Sp, or to four side chains Sp/Sp, including the one shown in formula (II). The various side chains Sp/Sp linked to the aromatic ring can be identical or different.

(16) Ar and Ar can be identical or different, preferably identical. Still preferably, Ar and Ar are phenyl groups. Alternatively, they can be naphthyl groups.

(17) In formula (I), L is a linking group or linker.

(18) The linking group L comprises at least one heteroatom and a spacer denoted as Sp.

(19) The heteroatom is preferably sulfur, nitrogen, or oxygen.

(20) In formula (II), L is either a covalent bond or a linking group; m and n are each independently 0 or 1; and Sp and Sp are side chainswhich can also be called spacers in the context of this application.

(21) When m=0, Sp is not present, whereas when m=1, Sp is present.

(22) When n=0, Sp is not present, whereas when n=1, Sp is present.

(23) At least one of Sp and Sp is present, which means that at least one of m and n is 1. According to one embodiment, only one of Sp and Sp is present. According to an alternative embodiment, both Sp and Sp are present, in which case they can be identical or different.

(24) In both of the above formulas, Sp, Sp and Sp are organic chains. In particular each of Sp, Sp and Sp can be an aromatic chain or an aromatic group-containing chain. However, preferably, each of Sp, Sp and Sp is an aliphatic chain. Each of Sp, Sp and Sp preferably comprises at least two carbon atoms.

(25) According to one embodiment, the chain Sp or Sp or Sp has 2 carbon atoms.

(26) According to one embodiment, the chain Sp or Sp or Sp has 3 carbon atoms.

(27) According to one embodiment, the chain Sp or Sp or Sp has 4 carbon atoms.

(28) According to one embodiment, the chain Sp or Sp or Sp has 5 carbon atoms.

(29) According to one embodiment, the chain Sp or Sp or Sp has 6 carbon atoms.

(30) According to one embodiment, the chain Sp or Sp or Sp has 7 carbon atoms.

(31) According to one embodiment, the chain Sp or Sp or Sp has 8 carbon atoms.

(32) According to one embodiment, the chain Sp or Sp or Sp has 9 carbon atoms.

(33) According to one embodiment, the chain Sp or Sp or Sp has 10 carbon atoms.

(34) According to one embodiment, the chain Sp or Sp or Sp has 11 carbon atoms.

(35) According to one embodiment, the chain Sp or Sp or Sp has 12 carbon atoms.

(36) According to one embodiment, the chain Sp or Sp or Sp has 13 carbon atoms.

(37) According to one embodiment, the chain Sp or Sp or Sp has 14 carbon atoms.

(38) According to one embodiment, the chain Sp or Sp or Sp has 15 carbon atoms.

(39) According to one embodiment, the chain Sp or Sp or Sp has 16 carbon atoms.

(40) According to one embodiment, the chain Sp or Sp or Sp has 17 carbon atoms.

(41) According to one embodiment, the chain Sp or Sp or Sp has 18 carbon 20 atoms.

(42) According to one embodiment, the chain Sp or Sp or Sp has 19 carbon atoms.

(43) According to one embodiment, the chain Sp or Sp or Sp has 20 carbon atoms.

(44) According to one embodiment, the chain Sp or Sp or Sp has more than 20 carbon atoms.

(45) The chain Sp or Sp or Sp may be linear, branched or cyclic. It can be saturated or unsaturated and is most preferably saturated. It can be substituted or, more preferably, non-substituted. In case it is substituted, alkyl chain substituents are preferred, as they contribute to a reduced tendency to explosiveness.

(46) The compounds of the invention can be both of type 1 and type 2 at the same time. Such compounds can be compounds of formula (I), wherein at least one of Ar and Ar comprises an aromatic ring with a respective chain Sp or Sp as defined above linked to said aromatic ring. Such compounds can also be compounds of formula (II), wherein L is a linking group similar to a linking group L of formula (I) defined above.

(47) Preferred compounds of type 1 are of the general formula:
N.sub.3O.sub.2SArY-Sp-YArSO.sub.2N.sub.3.(I)

(48) In this formula, Sp is as defined above; Y and Y are two functional groups which can be identical or different preferably, the two groups N.sub.3O.sub.2SArY and N.sub.3O.sub.2SArY respectively linked to the spacer Sp are identical.

(49) Such compounds are of the general formula:
(N.sub.3O.sub.2SArY).sub.2Sp.(I)

(50) The functional groups Y and Y advantageously comprise at least one heteroatom, preferably selected from sulfur, oxygen, and nitrogen.

(51) They are more preferably selected from the following groups: O, NH, NR, OC(O)NH, OC(O)NR, OC(O)O, NHC(O)NH, NHC(O)O, NHC(O)NR, NRC(O)NH, NRC(O)O, NRC(O)NR, S, SO.sub.2, C(O)O, C(O)NH, C(O)NR, C(O), OC(O), NHC(O) and NRC(O), wherein R and R are alkyl or aryl groups.

(52) More preferably, R and R are selected from the methyl, ethyl, propyl, isopropyl, 1-butyl, 2-butyl, isobutyl, tert-butyl, pentyl, isoamyl, 4-methyl-2-pentyl, 2-ethylhexyl, and phenyl groups.

(53) Preferred examples of compounds of type 1 are: 1,6-bis-(4-azidosulfonylphenoxy)-hexane, also designated POHOP-SA, having the following formula:

(54) ##STR00007## 1,10-bis-(4-azidosulfonylphenoxy)-decane, also designated PODOP-SA, having the following formula:

(55) ##STR00008## 1,2-bis-(4-azidosulfonylphenoxy)-hexadecane, also designated POTDEOP-SA, having the following formula:

(56) ##STR00009## 4,8-bis-(4-azidosulfonylphenoxymethyl)-tricyclo[5.2.1.0.sup.2.6-]decane (isomeric mixture), also designated POTCOP-SA, having the following formula:

(57) ##STR00010## 1,4-bis-(4-azidosulfonylphenoxymethyl)-cyclohexane, also designated POMCMOP-SA, having the following formula:

(58) ##STR00011## 1,n-bis-(4-azidosulfonylphenyl)-polyethylene glycol ether, also designated POPEGOP-SA, having the following formula:

(59) ##STR00012##

(60) Preferably, in the compounds of the invention of type 2, L is a functional group, advantageously comprising a heteroatom such as sulfur, nitrogen or oxygen. More preferably Y is selected from the following groups: O, NH, NR, OC(O)NH, OC(O)NR, OC(O)O, NHC(O)NH, NHC(O)O, NHC(O)NR, NRC(O)NH, NRC(O)O, NRC(O)NR, S, SO.sub.2, C(O)O, C(O)NH, C(O)NR, C(O), OC(O), NHC(O), and NRC(O), wherein R and R are alkyl or aryl groups.

(61) More preferably, R and R are selected from the methyl, ethyl, propyl, isopropyl, 1-butyl, 2-butyl, isobutyl, tert-butyl, pentyl, isoamyl, 4-methyl-2-pentyl, 2-ethylhexyl, and phenyl groups.

(62) Preferred examples of a compound of type 2 of the present invention are: 4,4-bis-(azidosulfonyl)-3-pentadecyl diphenylether, also designated PBSA, of the following formula:

(63) ##STR00013## a mixture of 2-fatty alkyl substituted DPO-BSA (i.e. a mixture of 4,4-bis-(azidosulfonyl)-2-hexadecyl diphenylether and 4,4-bis-(azidosulfonyl)-2-octadecyl diphenylether), also designated as H/ODPO-BSA, of the following formula:

(64) ##STR00014##

(65) A preferred example of a compound of a mixed type of the present invention (both type 1 and type 2) is: 1,6-bis-(4-azidosulfonyl-3-pentadecylphenoxy)hexane, also designated PDPOHOPDP-SA, of the following formula:

(66) ##STR00015##

(67) The compounds of the present invention can be prepared by reacting starting compounds A and B, optionally in the presence of an additional compound C. Compounds A and B are substituted aromatic compounds. They can be identical or different. They can bear sulfonylazide substituents. Alternatively, the sulfonylazide groups can be provided in one or more posterior reaction steps.

(68) In particular, in order to produce compounds of type 1 having the above formula (I), the starting compounds A and B are one and the same compound, and use can be made of a compound of formula Z-Sp-Z as an additional compound C, wherein Sp is as defined above, and Z is a reactive functional group.

(69) More specifically, some of the compounds of type 1 can be prepared according to so-called route 1, comprising the following first step:

(70) ##STR00016##

(71) In the above scheme, M.sup.+ represents a metallic cation, such as for instance sodium or potassium. Sp is a spacer (denoted Sp above) and L has a different meaning from formula (I).

(72) According to one embodiment, L is selected from O, NH, or NR, where R is an alkyl or an aryl group, as defined above, and X is selected from Cl, Br, I, NCO, OC(O)Cl, and NRC(O)Cl, where R is an alkyl or an aryl group, as defined above.

(73) According to another embodiment, LH is SH or S.sup.M.sup.+ and X is Cl, Br, or I.

(74) This reaction can be performed in the presence of an inorganic base such as MOH, M.sub.2CO.sub.3, or in the presence of an organic base.

(75) In case L is S, it is possible to then oxidize this linking group into SO.sub.2 e.g. by treatment of the sulfide with hydrogen peroxide.

(76) The first step is then followed by a second step of reacting the obtained compound with a chlorination agent. The chlorination agent can be for instance selected from thionylchloride, sulfurylchloride, phosphorylchloride, phosgene, oxalyl chloride, preferably thionylchloride.

(77) The second step is then followed by a third step of reacting the obtained sulfonyl chloride compound with an azide source, preferably sodium azide. The second and third steps can be illustrated as follows:

(78) ##STR00017##

(79) Route 1 makes it possible to obtain compounds of formula (I), wherein Y is O, NH, NR, OC(O)NH, OC(O)NR, OC(O)O, NHC(O)NH, NHC(O)O, NHC(O)NR, NRC(O)NH, NRC(O)O, NRC(O)NR, S, and SO.sub.2.

(80) The same compounds of type 1 can be prepared according to so-called route 2, comprising the following step:

(81) ##STR00018##

(82) In the above scheme, LH, L, and X have the same meanings as in route 1. This reaction can be performed in the presence of an inorganic base such as MOH, M.sub.2CO.sub.3, or in the presence of an organic base.

(83) Route 2 circumvents the need for any posterior chlorination or azidation step.

(84) Other compounds of type 1 can be prepared according to so-called route 3, comprising the following first step:

(85) ##STR00019##

(86) In the above scheme, X is O, NH, or NR, R being an alkyl or aryl group as defined above.

(87) This reaction can be performed in the presence of an inorganic base such as MOH, M.sub.2CO.sub.3, or in the presence of an organic base.

(88) The first step is then followed by a second step of reacting the obtained compound with sodium azide. The second step can be illustrated as follows:

(89) ##STR00020##

(90) Route 3 makes it possible to obtain compounds of formula (I), wherein Y is C(O)O, C(O)NH or C(O)NR.

(91) Other compounds of type 1 can be prepared according to so-called route 4, comprising the following first step:

(92) ##STR00021##

(93) In the above scheme, ALK is an alkyl chain, such as a methyl group for instance.

(94) This reaction can be performed in the presence of AlCl.sub.3 or any other Lewis acid.

(95) The first step is then followed by a second step of reacting the obtained compound with a mixture of Cl.sub.2 and H.sub.2O, and then by a third step of reacting the obtained sulfonyl chloride with an azide source like sodium azide. The second and third steps can be illustrated as follows:

(96) ##STR00022##

(97) Route 4 makes it possible to obtain compounds of formula (I), wherein Y is C(O).

(98) Some of the compounds of type 2 can be prepared according to so-called route 5, comprising the following first step:

(99) ##STR00023##

(100) In this scheme, X is Cl, or Br, or I. R and R are alkyl or aryl groups, as defined above. One of R and R can be omitted; at least one of R and R is or contains the above-defined spacer Sp or Sp. Preferably, R is -Sp-H or R is -Sp-H.

(101) This reaction step is preferably catalyzed by a transition metal catalyst, e.g. based on copper or palladium.

(102) The first step is then followed by a second step of reacting the obtained compound with a chlorosulfonation agent. For instance, use may be made of at least four equivalents chlorosulfonic acid for direct chlorosulfonation, or at least two equivalents chlorosulfonic acid or sulfuric acid followed by a chlorination as described in route 1, or sulfurylchloride, etc.

(103) The second step is then followed by a third step of reacting the obtained compound with an azide source like sodium azide. The second and third steps can be illustrated as follows:

(104) ##STR00024##

(105) Route 5 thus makes it possible to prepare compounds of type 2 wherein L is O.

(106) Some of the compounds of type 2 can be prepared according to so-called route 6, comprising the following first and second steps:

(107) ##STR00025##

(108) In this scheme, R and R are alkyl or aryl groups, as defined above. One of R and R can be omitted; at least one of R and R is or contains the above-defined spacer Sp or Sp. L has a different meaning from above in this scheme.

(109) In the first step, LH is OH, NH.sub.2 or NRH, where R is an alkyl or aryl group having the same general definition as R and R.

(110) In the second step, LX is OC(O)Cl, NCO or NRC(O)Cl, R being as defined above; and LH is OH, NH.sub.2 or NRH, where R is an alkyl or aryl group having the same general definition as R and R.

(111) In the compound obtained at the second step, L has a different meaning and can be OC(O)O, OC(O)NH, OC(O)NR, NHC(O)O, NRC(O)O, NHC(O)NH, NHC(O)NR, NRC(O)NH or NRC(O)NR, R and R being as defined above.

(112) The second step is followed by a third step of chlorosulfonation and a fourth step of reacting with sodium azide, which are analogous to the second and third step of route 5.

(113) Some of the compounds of type 2 can be prepared according to so-called route 7, comprising the following first step:

(114) ##STR00026##

(115) In this scheme, X is Cl, or Br or I; and R and R are alkyl or aryl groups, as defined above. One of R and R can be omitted; at least one of R and R is or contains the above-defined spacer Sp or Sp. This reaction step is preferably catalyzed with a transition metal catalyst, based e.g. on copper or palladium.

(116) This first step is followed by a second step of chlorosulfonation and a third step of reacting with an azide source like sodium azide, which are analogous to the second and third step of route 5.

(117) Route 7 makes it possible to obtain compounds of type 2, wherein L in formula (II) is a covalent bond.

(118) Some of the compounds of type 2 can be prepared according to so-called route 8, comprising the following first step:

(119) ##STR00027##

(120) In this scheme, X is Cl, or Br or I; and R and R are alkyl or aryl groups, as defined above; and L is S or SO.sub.2. The reaction is performed in the presence of a compound M.sub.2S, where M is a metallic element (for instance sodium or potassium) and in the presence of a catalyst, preferably a transition metal catalyst, e.g. based on copper.

(121) An oxidation step is then performed if the SO.sub.2 linking group is desired e.g. by treatment of the sulfide with hydrogen peroxide.

(122) Then, a second step of chlorosulfonation and a third step of reaction with an azide source like sodium azide are performed, in an analogous manner as in route 5.

(123) Route 8 makes it possible to obtain compounds of type 2, wherein L in formula (II) is S or SO.sub.2.

(124) Some of the compounds of type 1 can be prepared according to so-called route 9, comprising the following first step: the activation of a diol for a subsequent nucleophilic substitution, e.g. as a sulfonate like a mesylate or a tosylate.

(125) The first step is then followed by a second step of a substitution of the activated diol with two equivalents of a hydroxyarene sulfonic acid, e.g. 4-hydroxybenzene sulfonic acid.

(126) The second step is then followed by a third step of an activation of the sulfonic acid groups for the azidation, e.g. as a sulfonyl chloride by treating the sulfonic acid with thionyl chloride.

(127) The third step is then followed by a fourth step of the sulfonyl azide formation by reacting the activated sulfonic acid with an azide, e.g. sodium azide.

(128) Route 9 makes it possible to obtain compound of formula (I) wherein Y is a diol like 4,8-bis hydroxymethyl tricyclo[5.2.1.0.sup.2.6]decane to form POTCOP-SA or 1,4-bis hydroxymethyl cyclohexane to form POMCMOP-SA.

(129) In order to prepare compounds of the invention where the aromatic building blocks Ar and Ar are not based on phenyl groups but rather on different aryl groups, similar reaction routes may be employed by analogy.

(130) One or more compounds of the invention can be formulated in a cross-linker composition. According to one embodiment, this cross-linker composition is devoid of any phlegmatizing agent. According to an alternative embodiment, this cross-linker composition comprises a phlegmatizing agent. A phlegmatizing agent is defined as an inert compound which reduces the explosiveness of the bissulfonylazide compound, according to the tests defined in the UN manual for tests and criteria.

(131) Phlegmatizing agents can be organic or inorganic compounds. Organic compounds can be solvents or solids like e.g. Irganox 1010. Inorganic compounds can be e.g. diatomaceous earth or silica gel.

(132) The amount of phlegmatizing agent used in the present invention can be varied over a wide range, depending on how much phlegmatizing agent is required to ensure safe handling and use of the compounds of the invention and to allow a transport classification as non-explosive material. In particular, the amount of phlegmatizing agent in the compositions of the invention can be from 0 to 50% (w/w), preferably from 0 to 40% (w/w), more preferably from 0 to 30% (w/w), even more preferably from 0 to 20% (w/w), and most preferably from 0 to 10% (w/w).

(133) The compounds and compositions of the invention are useful in the manufacture of polymers such as polyolefins (in particular polypropylene and polyethylene), in the cross-linking of polymers, and in the manufacture of synthetic rubber.

EXAMPLES

(134) The following examples illustrate the present invention without limitation.

Example 1: Synthesis of POHOP-SA

(135) ##STR00028##

Step 1: 1,6-bis-(4-sulfophenoxy)-hexane disodium salt (POHOP-SONa)

(136) ##STR00029##

(137) A solution of 320 sodium hydroxide in 480 g water was added slowly at 25 C. to a solution of 1858 g sodium 4-hydroxybenzene sulfonate and 12.8 g tetrabutylammonium bromide in 3120 g water. To this mixture 976 g 1,6-dibromohexane was added within 1 h. The mixture was heated to 100 C. and stirred for 15 h. The thick slurry was diluted with 400 ml water and stirred for another 7 h at 100 C. The suspension was diluted with 11.6 L water and stirred at 100 C. for 8 h and then cooled to room temperature for filtration. The solids were washed with 4 L water followed by 4 L acetone and dried at 50 C. 1599 g of a white solid with an assay of 92.5% (w/w, HPLC) was isolated, with chemical yield of 80%.

(138) Analytical data:

(139) Melting point >345 C.; 1H-NMR (300 MHz in D.sub.2O): 7.65 ppm (d, 4H), 6.97 ppm (d, 4H), 4.02 ppm (t, 4H), 1.70 ppm (broad quintet, 4H), 1.40 ppm (broad, 4H).

Step 2: 1,6-bis-(4-chlorosulfonylphenoxy)-hexane (POHOP-SC)

(140) ##STR00030##

(141) A mixture of 1471 g POHOP-SONa, 7 kg thionyl chloride, and 7 g dimethylformamide (DMF) was heated to 75V for 17 h. 3.5 kg thionyl chloride were removed by distillation at 50 C. and 100 mbar and the distillation was continued after the addition of three times each 2 L toluene until a distillation residue of 2.3 kg was obtained. It was diluted with 1.5 L toluene and cooled to 17 C. The solids were filtered off and washed with 1.5 L toluene. The wet filter cake was slurried in 2.5 L water in order to removed salts and residual traces of thionyl chloride. The solids were filtered, washed with 2.5 L water, and dried at 40 C. 1329 g of a white solid was obtained. The chemical yield based on the mass of the product is 99%.

(142) Analytical data:

(143) Melting point: 126-128 C.; 1H-NMR (300 MHz in CDCl 3): 7.97 ppm (d, 4H), 7.05 ppm (d, 4H), 4.11 ppm (t, 4H), 1.90 ppm (broad quintet, 4H), 1.60 ppm (broad, 4H).

Step 3: 1,6-bis-(4-azidosulfonylphenoxy)-hexane (POHOP-SA)

(144) ##STR00031##

(145) A solution of 406 g sodium azide in 3.25 L water was added within 15 min to a solution of 1328 g POHOP-SC in 16.25 L acetone. The mixture was stirred at room temperature for 53 h and then diluted with 14.8 L water in order to dissolve salts. The solids were recovered by filtration and washed with 9 L water. After 2 days of drying at 40 C., 1301 g of a white solid was isolated. The chemical yield was 98% based on an assay determination of 96.6% w/w by NMR.

(146) Analytical data:

(147) Melting point: 93-95 C.; 1H-NMR (300 MHz in CD2Cl2): 7.91 ppm (d, 4H), 7.10 ppm (d, 4H), 4.12 ppm (t, 4H), 1.90 ppm (broad quintet, 4H), 1.60 ppm (broad, 4H).

Example 2: Safety Tests for POHOP-SA in Comparison with DPO-BSA

(148) Neat POHOP-SA is neither shock sensitive in the BAM-fallhammer test with an impact energy of 40 J, nor friction sensitive in the BAM-friction apparatus with a friction force of 360 N.

(149) Neat POHOP-SA is explosive according to the Koenen test with a bore hole diameter of 2 mm according to the UN Manual of Tests and Criteria, Part I, Revision V, United Nations, 2009, p. 33 ff (section 11.5.1).

(150) POHOP-SA with 5% Irganox 1010 is still explosive in the Koenen test at 2 mm bore hole diameter but not anymore in a mixture containing 10% Irganox 1010.

(151) For comparison, according to safety tests, POHOP-SA requires only 10% Irganox 1010 for sufficient phlegmatization whereas the comparative example DPO-BSA requires more than 33% Irganox 1010.

Example 3: Synthesis of PODOP-SA

(152) ##STR00032##

Step 1: 1,10-bis-(4-sulfophenoxy)-decane disodium salt (PODOP-SONa)

(153) ##STR00033##

(154) A solution of 40 g sodium hydroxide in 60 g water was added slowly at 25 C. to a thin suspension of 232.2 g sodium 4-hydroxybenzene sulfonate in a mixture of 198 g water and 218 g DMSO. To this mixture, 150 g of 1,10-dibromodecane was added within 20 min. The mixture was refluxed at 113 C. for 24 h, and then cooled to room temperature for filtration. The solids were washed with 0.9 L water followed by 1 L acetone and dried at 50. 244.6 g of a white solid with a purity of 94.1 area-% (HPLC) was isolated with a chemical yield of 87%.

(155) Analytical data:

(156) Melting point >350 C.; 1H-NMR (300 MHz in DMSO): 7.4 9 ppm (d, 4H), 6.84 ppm (d, 4H), 3.95 ppm (t, 4H), 1.70 ppm (m, 4H), 1.25-1.45 ppm (broad, 12H).

Step 2: 1,10-bis-(4-chlorosulfonylphenoxy)-decane (PODOP-SC)

(157) ##STR00034##

(158) A mixture of 244.1 g PODOP-SONa, 821 g thionyl chloride, and 2.4 g DMF was heated to 75 C. for 7 h. 330 g thionyl chloride were removed by distillation at 50 C. and 100 mbar. The residue was diluted with 900 mL petrolether 30/50 at 25 C. The solids were filtered off after 24 h and washed with 500 ml petrolether 30/50. The wet filter cake was slurried in 910 mL water in order to remove salts and residual traces of thionyl chloride. The solids were filtered, washed with 0.5 l water, and dried at 40 C. 228.3 g of a light brown solid was obtained. The chemical yield based on the mass of the product was 98%.

(159) Analytical data:

(160) Melting point: 63-65 C.; 1H-NMR (300 MHz in CDCl3): 7.98 ppm (d, 4H), 7.05 ppm (d, 4H), 4.08 ppm (t, 4H), 1.85 ppm (broad quintet, 4H), 1.30-1.60 ppm (broad, 12H).

Step 3: 1,10-bis-(4-azidosulfonylphenoxy)-decane (PODOP-SA)

(161) ##STR00035##

(162) A solution of 69.7 g sodium azide in 609 mL water was added within 30 min to a solution of 227.7 g PODOP-SC in 3.04 L acetone. The mixture was stirred at room temperature for 24 h and then diluted with 2.53 L water in order to dissolve salts. The solids were recovered by filtration and washed with 0.6 L water. After 2 days of drying at 40 C., 210 g of a light brown solid was isolated. 208 g of the crude product was dissolved in 330 g acetone. 1 g activated charcoal and 2 g diatomaceous earth were added and the mixture was filtered at 55 C. The filtrate was cooled to 26 C. when crystallization started with a temperature rise to 29 C. At this temperature, 208 mL water was added to the mixture and the solids were recovered by filtration and washed with 208 mL water. Drying at 400 resulted in 204.7 g off-white PDOOP-SA with 98.4 area-% purity. The chemical yield was 88%.

(163) Analytical data:

(164) Melting point: 89-91 C.; 1H-NMR (300 MHz in DMSO): 7.93 ppm (d, 4H), 7.23 ppm (d, 4H), 4.11 ppm (t, 4H), 1.74 ppm (broad quintet, 4H), 1.25-1.45 ppm (broad, 12H).

Example 4: Safety Tests for PODOP-SA in Comparison with DPO-BSA

(165) Neat PODOP-SA is neither shock sensitive in the BAM-fallhammer test with an impact energy of 40 J nor friction sensitive in the BAM-friction apparatus with a friction force of 360 N.

(166) Neat PODOP-SA is not explosive according to the Koenen test with a bore hole diameter of 2 mm.

(167) According to the time/pressure test, it does not deflagrate quickly.

(168) According to these safety tests, PODOP-SA is not explosive, does not have to be included in class 1 according to transport regulations and thus does not have to be phlegmatized at all.

Example 5: Synthesis of POMCMOP-SA

(169) ##STR00036##

Step 1: 1,4-bis-(methane sulfonyloxymethyl)-cyclohexane (MCM-OMs)

(170) ##STR00037##

(171) To a cold mixture of 46.9 g 1,4-bis-(hyroxymethyl) cyclohexane (mixture of cis and trans isomers), 79.3 g triethylamine, and 350 ml THF was added 84.1 g methane sulfonyl chloride slowly at max. 25 C. 200 ml THF and 10 ml methane sulfonyl chloride were added and the mixture was quenched with 400 ml water. The solids were recovered by filtration and dried at 40 C. to yield 78.2 g of a white solid (80% chemical yield; mixture of two isomers). A second crop of 8.5 g (9% chemical yield) was isolated from the mother liquor as crystals that formed upon standing over night. This minor product was determined by X-ray crystallography to be the cis-isomer. The major compound of the main fraction was the trans-isomer (82:18).

(172) Analytical data:

(173) .sup.1H-NMR (300 MHz in CDCN): 4.14/4.04 ppm (d, 4H), 3.02 ppm (s, 6H), 1.1 to 2.2 ppm (several signals, 10H).

Step 2: 1,4-bis-(4-sulfophenoxymethyl)-cyclohexane disodium salt (POMCMOP-SONa)

(174) ##STR00038##

(175) A suspension of 69.3 g sodium 4-hydroxybenzene sulfonate in a solution of 10.8 g sodium hydroxide in 230 ml water was added at 25 C. to a solution of 38.7 g MCM-OMs in 220 ml DMSO. The mixture was heated to 1200 and stirred for a total of 28 h. The slurry was cooled to 5 and filtered. The solids were washed with acetone and re-crystallized from 2 l water. A first crop of 27.4 g (43% chemical yield) was isolated by filtration at 350 and a second crop of 6.4 g (10% chemical yield) at 50. The isolated product contained only one isomer, due to the yield in comparison to the 82:18 composition of the starting material isomer mixture most likely the trans-isomer.

(176) Analytical data:

(177) .sup.1H-NMR (300 MHz in D.sub.2O): 7.66 ppm (d, 4H), 7.00 ppm (d, 4H), 3.89 ppm (d, 4H), 1.85 ppm (d, 4H), 1.73 (broad, 2H), 1.60 ppm (quintet, 4H).

Step 3: 1,4-bis-(4-chlorosulfonylphenoxymethyl)-cyclohexane (POMCMOP-SC)

(178) ##STR00039##

(179) A mixture of 27.4 g POMCMOP-SONa, 588 g thionyl chloride, and 0.8 g dimethylformamide (DMF) was heated to 500 for 6 h and stirred at room temperature for 60 h. The excess of thionyl chloride was removed by distillation at 50 C. in vacuum. The remaining solid was stirred in a mixture of dichloromethane and ice water. A filtration yielded 17.3 g (64% chemical yield) white solid. The organic phase was boiled down to a suspension which was heated until the solids dissolved and cooled for the crystallization of a second crop of 3.1 g (11% chemical yield) product:

(180) Analytical data:

(181) .sup.1H-NMR (300 MHz in CD.sub.2Cl.sub.2): 8.00 ppm (d, 4H), 7.09 ppm (d, 4H), 3.95 ppm (d, 4H), 2.03 ppm (d, 4H), 1.91 (broad, 2H), 1.22 ppm (quintet, 4H).

Step 4: 1,4-bis-(4-azidosulfonylphenoxymethyl)-cyclohexane (POMCMOP-SA)

(182) ##STR00040##

(183) A solution of 1 g sodium azide in 11 ml water was added to a solution of 3.1 g POMCMOP-SC in 20 ml acetone. The mixture was diluted with 20 ml acetone and stirred at room temperature for 24 h. The mixture was stirred for additional 12 h after the addition of 0.1 g sodium azide. The solids were recovered by filtration, washed with water, and dried at 20 mbar. The product was isolated in quantitative yield.

(184) Analytical data:

(185) Melting point: 144 C. (DSC); .sup.1H-NMR (300 MHz in CD2Cl2): 7.91 ppm (d, 4H), 7.10 ppm (d, 4H), 3.94 ppm (d, 4H), 2.03 ppm (d, 4H), 1.90 (broad, 2H), 1.23 ppm (quintet, 4H).

Example 6: Limited Safety Tests for POMCMOP-SA in Comparison with DPO-BSA

(186) Neat POMCMOP-SA releases 1306 J/g energy with an onset at 168 C. in a DSC-measurement. It is neither shock sensitive in the BAM-fallhammer test with an impact energy of 40 J, nor friction sensitive in the BAM-friction apparatus with a friction force of 360 N.

Comparative Example: Explosive Properties of DPO-BSA

(187) ##STR00041##

(188) Neat DPO-BSA is shock sensitive in the BAM-fallhammer test with an impact energy of 15 J (like the commercial explosive TNT) but not friction sensitive in the BAM-friction apparatus with a friction force of 360 N. Neat DPO-BSA is explosive according to the Koenen test with a bore hole diameter of 2 mm.

(189) According to safety tests, DPO-BSA requires more than 33% Irganox 1010 for sufficient phlegmatization.

Example 7: Application of POHOP-SA and PODOP-SA for Cross-Linking of Polypropylene

(190) Polypropylene (Moplen HP 500 N) was partially cross-linked with POHOP-SA or PODOP-SA. For this a dry blend of POHOP-SA with Irganox 1010 in the mass ratio 90:10 or PODOP-SA without phlegmatizing agent powder was prepared with polypropylene. In the comparative experiments DPO-BSA in a mixture with Irganox 1010 in the mass ratio 24:76 was used in equimolar amounts of DPO-BSA compared to POHOP-SA and PODOP-SA with polypropylene (Moplen HF 500). A mixture of polypropylene and the dry blend was passed through a twin screw extruder at 100 to 230. The extruded polymer was cooled in a water bath and chopped into pieces.

(191) The mechanical characteristic data (tensile modulus, tensile stress, tensile strain) of the modified polypropylene were measured with a testing machine UPM 1455 from the company Zwick. It is apparent from the results given in the tables 1 and 2 that the new cross linking agents POHOP-SA and PODOP-SA show similar performance as DPO-BSA in the comparative example. The increase of tensile modulus is measured between a non-cross-linked and a cross-linked polypropylene. The tensile modulus, tensile stress and tensile strain are measured at a frequency of 0.04 rad/second.

(192) TABLE-US-00001 TABLE 1 Test results for PP treated with 0.329 mmol cross linker per 1 kg PP Cross linker DPO-BSA 24% POHOP-SA PODOP-SA (reference 90% 100% cross-linker) Tensile modulus 1598 1605 1661 [MPa] Increase of 9 10 9 tensile modulus [%] Tensile stress 35 36 36 [MPa] Tensile strain [%] 9 9 8

(193) TABLE-US-00002 TABLE 2 Test results for PP treated with 0.657 mmol cross linker per 1 kg PP Cross linker DPO-BSA 24% POHOP-SA PODOP-SA (reference 90% 100% cross-linker) Tensile modulus 1675 1683 1737 [MPa] Increase of 14 15 14 tensile modulus [%] Tensile stress 36 36 37 [MPa] Tensile strain [%] 9 9 8

(194) The Charpy notch impact strength was tested, according to DIN-EN ISO 179, for polypropylene and polypropylene modified with POHOP-SA or PODOP-SA (See table 3). Both cross-linkers result in an increased notch impact strength versus non-cross-linked polypropylene, a higher cross-linker ratio to polypropylene resulting in an increased notch impact strength.cross-link. The effect is more pronounced for PODOP-SA than for POHOP-SA.

(195) TABLE-US-00003 TABLE 3 Charpy notch impact strength for PP treated with POHOP-SA or PODOP-SA [kJ/m.sup.2] amount of phlegmatizing agent [mmol/kg] 0 0.329 0.657 2.629 POHOP-SA 90% with 2.7 2.8 2.9 3.9 Irganox 1010 PODOP-SA 2.7 3.0 3.3 4.1

Example 8: Application of POHOP-SA and PODOP-SA for Cross-Linking of High Density Polyethylene

(196) High density polyethylene (Lupolen 5031 L Q 449 KHDPE) was partially cross-linked with POHOP-SA or PODOP-SA. For this a dry blend of POHOP-SA with Irganox 1010 in the mass ratio 90:10 or PODOP-SA without phlegmatizing agent was prepared with HDPE powder. In the comparative experiments DPO-BSA in a mixture with Irganox 1010 in the mass ratio 24:76 was used in equimolar amounts of DPO-BSA compared to POHOP-SA and PODOP-SA with HDPE. A mixture of HDPE and the dry blend was passed through a twin screw extruder at 100 to 200 C. The extruded polymer was cooled in a water bath and chopped into pieces.

(197) As for polypropylene, it is apparent, from the results given in the table 4, that the new cross linking agents POHOP-SA and PODOP-SA show the similar performance as DPO-BSA in the comparative example.

(198) TABLE-US-00004 TABLE 4 Test results for HDPE treated with 2.629 mmol cross linker per 1 kg HDPE Cross linker DPO-BSA 24% POHOP-SA PODOP-SA (reference 90% 100% cross-linker) Tensile modulus 907 861 886 [MPa] Increase of 2 7 5 tensile modulus [%] Tensile stress 25 24 24 [MPa] Tensile strain [%] 10 10 10

(199) The rheological properties of partially cross-linked HDPE were measured at 150 C. in a nitrogen atmosphere with a p late rheometer of the company Rheometrics (plate diameter 25 mm; plate distance 1 mm).

(200) Compared with non-cross-linked HDPE, the complex viscosity increases with increasing molar amount of POHOP-SA per 1 kg of HDPE (see FIG. 1). Compared with non-cross-linked HDPE, the complex viscosity was increased by a factor of almost 7 at a frequency of 0.04 rad/s, with 2.629 mmol POHOP-SA per 1 kg of HDPE

(201) Making reference to FIGS. 2 and 3, at low levels of 0.329 and 0.657 mmol POHOP-SA for 1 kg HDPE the loss modulus (G) increased moderately whereas the storage modulus (G) increased significantly (FIG. 2). The increase is very significant with 2.629 mmol POHOP-SA for 1 kg HDPE (FIG. 3).

(202) The results with PODOP-SA were very similar to POHOP-SA (see FIGS. 4, 5, and 6).

(203) The effect of PODOP-SA on the complex viscosity was greater than that of the reference cross-linker DPO-BSA at 2.629 mmol cross-linker for 1 kg HDPE (FIG. 7).

(204) The effect of PODOP-SA on the loss and storage modulus was greater than that of the reference cross-linker DPO-BSA at 2.629 mmol cross-linker for 1 kg HDPE (FIG. 8).

(205) In comparison with DPO-BSA, the same molar amount of new azides to HDPE provides a higher value of loss and/or storage modulus. For a given target value of loss and/or storage modulus, a smaller molar amount of new azides is sufficient compared to DPO-BSA.

(206) The melt strength of HDPE and partially cross-linked HDPE was measured with a stretch tester of the type Rheotens in combination with a high pressure capillary rheometer of the type Rheograph 2000 both of the company Gttfert. The melt strand was extruded at a constant speed of 11.3 mm/s through a nozzle. The stretching was measured with the Rheotens equipment which was set up at 125 mm distance from the nozzle. The pull-off roll was accelerated with 2.4 mm/s.sup.2 until the melt strand ripped off.

(207) HDPE without cross-linking has a pull-off force of 0.013 N and the pull-off speed as a relative measure for the melt strength is 320 to 360 m/s.

(208) Both, 2.629 mmol/kg POHOP-SA and PODOP-SA increase the pull-off force by a factor 3 to 0.04 N.

(209) POHOP-SA increases the pull-off speed by a factor 2. With PODOP-SA the pull-off speed remains at the same level as without cross-linking.

(210) POHOP-SA has an additional advantage as the processing of HDPE can be improved to significantly higher speeds.