PROCESS FOR MANUFACTURING A MONOLITHIC PART
20240165871 ยท 2024-05-23
Assignee
Inventors
Cpc classification
B33Y10/00
PERFORMING OPERATIONS; TRANSPORTING
B29C64/386
PERFORMING OPERATIONS; TRANSPORTING
B33Y70/00
PERFORMING OPERATIONS; TRANSPORTING
B29C64/282
PERFORMING OPERATIONS; TRANSPORTING
A61F2002/2835
HUMAN NECESSITIES
B33Y50/00
PERFORMING OPERATIONS; TRANSPORTING
B22F2999/00
PERFORMING OPERATIONS; TRANSPORTING
B22F10/12
PERFORMING OPERATIONS; TRANSPORTING
B33Y40/20
PERFORMING OPERATIONS; TRANSPORTING
A61F2002/30766
HUMAN NECESSITIES
B22F2998/10
PERFORMING OPERATIONS; TRANSPORTING
B33Y80/00
PERFORMING OPERATIONS; TRANSPORTING
B33Y50/02
PERFORMING OPERATIONS; TRANSPORTING
B22F10/38
PERFORMING OPERATIONS; TRANSPORTING
B29C64/129
PERFORMING OPERATIONS; TRANSPORTING
A61F2002/30031
HUMAN NECESSITIES
A61F2/0077
HUMAN NECESSITIES
B29C64/124
PERFORMING OPERATIONS; TRANSPORTING
B29C64/277
PERFORMING OPERATIONS; TRANSPORTING
B22F2998/10
PERFORMING OPERATIONS; TRANSPORTING
B22F2999/00
PERFORMING OPERATIONS; TRANSPORTING
B33Y70/10
PERFORMING OPERATIONS; TRANSPORTING
B29L2031/7532
PERFORMING OPERATIONS; TRANSPORTING
A61F2002/0086
HUMAN NECESSITIES
International classification
B29C64/124
PERFORMING OPERATIONS; TRANSPORTING
B29C64/282
PERFORMING OPERATIONS; TRANSPORTING
Abstract
The invention relates to a process for manufacturing a monolithic part, wherein different surface topologies are created in specifically selected regions in order to create different surface properties, in particular with respect to a wetting behavior, a deposition behavior and/or a colonization with cells.
Claims
1. A process for producing a monolithic component, wherein different surface topologies for realizing different surface properties, in particular in terms of wetting behaviour, deposition behaviour and/or colonization with cells, are produced in specifically selected regions.
2. The process according to claim 1, wherein the monolithic component is produced from a component design (CAD) having a multiplicity of design elements (E), wherein at least one design orientation (X.sub.M, Y.sub.M, Z.sub.M) of a design element (E) relative to a build space orientation (X, Y, Z) of an actual build space (X, Y, Z) is specifically altered.
3. The process according to claim 1 comprising the steps of: forming the monolithic component using an additive manufacturing technique, wherein a photopolymerizable material (1) is provided in a tray having a transparent horizontal tray bottom (2), a platform (4) is immersed in the photopolymerizable material (1) to a predetermined distance from the tray bottom (2), a selective irradiation (8) through the tray bottom (2) is performed to produce a polymerized layer body (S.sub.x) adherent to the platform (4) which has a height corresponding to the distance, the platform (4) comprising the polymerized layer body (S.sub.x) is vertically displaced to form a subsequent layer body (S.sub.x+1) and by repeating the preceding layer production steps the monolithic component (7) is built up layerwise in the desired shape, wherein a surface of the component at least partially has a stepped structure, wherein adjusting manufacturing parameters during the repeating of the layer production steps produces different surface topologies for realizing different surface properties in selected regions of the monolithic component (7).
4. The process according to claim 3, wherein the selective irradiation (8) is carried out using a digital micromirror unit (6) comprising a multiplicity of micromirrors (M) arranged in rows and columns.
5. The process according to claim 3, wherein as a manufacturing parameter an irradiation parameter, in particular an irradiation intensity and/or an irradiation time, is in the selective irradiation (8) through the tray bottom (2) adjusted such that simultaneously with the layer body to be polymerized a photopolymerizable residual material (R) remaining in the edges and/or corners of a step structure disposed thereabove is polymerized.
6. The process according to claim 3, wherein as a manufacturing parameter a rotation angle (?) of horizontal micromirror principal axes (X, Y) relative to horizontal design element principal axes (X.sub.M, Y.sub.M) is altered during the repeating of the layer production steps.
7. The process according to claim 3, wherein as a manufacturing parameter a tilting angle (B) between a vertical design element principal axis (Z.sub.M) and a perpendicular (Z) to the horizontal tray bottom is altered during the repeating of the layer production steps.
8. The process according to claim 3, wherein as a manufacturing parameter the distance between the platform/the last polymerized layer body (S.sub.x) and the tray bottom (2) is altered during the repeating of the layer production steps.
9. The process according to claim 4, wherein as a manufacturing parameter the dimensions of the pixels (P) reflected by the micromirrors (M) of the micromirror unit are altered via an imaging unit (O) during the repeating of the layer production steps.
10. The process according to claim 3, wherein the photopolymerizable material comprises: a material from the class of polymers, in particular PA, PEK, PEKK, UHMWPE or PCL, a material from the class of metals, in particular Ti or stainless steel; a material from the class of metal alloys, in particular Ti64 or CoCr, a material from the class of magnesium alloys, in particular MgCa, MgZr or MgZn, a material from the class of ceramics, in particular Al.sub.2O.sub.3, ZrO.sub.2, Si.sub.3N.sub.4 or Ca.sub.3(PO.sub.4).sub.2, and/or a material from the class of glasses.
11. The process according to claim 3, wherein the production of the monolithic component (7) is followed by a cleaning, debindering and/or sintering.
12. The process according to claim 1, wherein the monolithic component (7) is a joint implant for tissue regeneration at the joint.
13. The process according to claim 1, wherein the monolithic component (7) is a technical functional body.
14. A digital storage medium with electronically readable control signals which can interact with a computer system such that a process according to claim 1 is executed.
15. A computer program product comprising non-transitory program code stored on a machine-readable storage medium for performing the process according to claim 1 when the program is executed on a computer.
16. The computer program comprising program code for performing the process according to claim 1 when the program is executed on a computer.
Description
[0025] In the figures:
[0026]
[0027]
[0028]
[0029]
[0030]
[0031]
[0032]
[0033] The subsequent description relates in particular to a process for producing a joint implant for tissue regeneration at a joint. In the same way the process may also be used for producing technical functional materials where wetting behaviour may be adjusted at different surface regions through targeted alteration of surface topologies.
[0034]
[0035] Such a 3-D printer produced for example by Lithoz? is for example based on a lithography-based manufacturing technique, wherein starting from a CAD model of the component to be manufactured the corresponding data sets are directly transmitted to a control unit of the 3-D printer (not shown).
[0036] A photopolymerizable material 1 may for example be introduced into a tray having a transparent horizontal tray bottom 2 and uniformly distributed in the tray for example with a height adjustable smoothing element/doctor blade 3. The employed photopolymerizable material 1 may be for example a ceramic suspension (particle-laden dispersion, also known as slip). A platform 4 movable in the Z-direction (vertical) is immersed into the photopolymerizable material 1 to a predetermined distance to the tray bottom 2 before a selective irradiation of the photopolymerizable material 1 is performed to form a polymerized 3D layer body adherent to the platform. The height of the polymerized layer body corresponds to the predetermined distance of the platform 4 from the tray bottom 2, while its base area corresponds to a respective irradiation area. The selective irradiation may therefore be understood as meaning in particular a site-selective irradiation.
[0037] As per
[0038] The platform 4 comprising the first polymerized layer body may subsequently be displaced vertically upwards in the Z-direction, photopolymerizable material 1 may optionally be replenished as required and optionally smoothed/uniformly distributed with the smoothing element 3 and the platform finally re-immersed into the photopolymerizable material 1 to a predetermined distance of the previously polymerized layer body to the tray bottom 2 and (site-) selectively irradiated to form a further polymerized layer body. Repetition of these layer production steps finally forms the desired monolithic and three-dimensional component 7 (green body) from a multiplicity of polymerized and mutually adherent layer bodies, wherein a surface of the component in the Z-direction may at least partially have a stepped structure/topology.
[0039] As per
[0040]
[0041] As per
[0042] In
[0043] The process for layerwise buildup of a monolithic component with the apparatus according to
[0044] The completion of the additively manufactured 3-D layer body/green body 7 may be followed by a final cleaning, debindering and sintering, thus making it possible to obtain the final monolithic component.
[0045] The axes X, Y and Z shown in
[0046] By way of example the photopolymerizable material 1 may comprise a polymer, in particular PA, PEK, PEKK, UHMWPE or PCL; a metal, in particular Ti or stainless steel; a metal alloy, in particular Ti64 or CoCr; a magnesium alloy, in particular MgCa, MgZr or MgZn; a ceramic, in particular Al2O3, ZrO2 or Ca3 (PO4) 2; and/or Si3N4. This makes it possible to realize for example a high mechanical strength joint implant having improved properties for tissue regeneration or a technical functional body having improved properties in terms of mechanical wear, use as a sensor, use as a capacitor, use as a catalyst, electrophoresis and/or targeted deposition of materials. The green body may either be used as a particle-filled polymer component or, after subsequent processing, be in the form of a metallic/ceramic component.
[0047] It is in principle also possible to employ, especially for production of the joint implant, further medically approved, bioinert and biocompatible as well as 3-D-printable materials for the photopolymerizable material 1.
[0048]
[0049]
[0050]
[0051] According to the invention it is now possible already during the design of the respective design elements E to effect specific alteration of a design orientation (X.sub.M, Y.sub.M, Z.sub.M) such that a different surface topology and thus surface property is realized for the contemplated design surface O.sub.M of the design element E. In particular the specific alteration of the design orientation (X.sub.M, Y.sub.M, Z.sub.M) relative to a build space orientation (X, Y, Z) shown in
[0052]
[0053]
[0054] As per
[0055]
[0056] Thus, according to this second exemplary embodiment alteration of a rotation angle ? between the horizontal design element principal axes X.sub.M, Y.sub.M and a projected row/column alignment X, Y of the micromirror unit 6 during the repeating of the layer production steps allows specific alteration of a surface topology of the monolithic component 7, thus making it possible to realize for example different wetting behaviour in different local regions.
[0057]
[0058] In
[0059]
[0060] With respect to the horizontal principal axes of the tray bottom the design element principal axis Z.sub.M may be tilted by a tilting angle ?.sub.x in the X-direction and by a tilting angle ?.sub.y in the Y-direction. Tilting both in the X-direction and in the Y-direction may also take place (?.sub.x,y).
[0061]
[0062] In
[0063] Similarly,
[0064] Similarly,
[0065] A tilting of the vertical design element principal axis Z.sub.M relative to a vertical build space principal axis z/the perpendicular to the horizontal tray bottom 2 thus also allows specific alteration of the stepped surface topologies, thus in turn making it possible to specifically adjust wetting behaviour at the respective surfaces.
[0066] As a manufacturing parameter it is further possible to alter the distance between the platform/the last polymerized layer body and the tray bottom during the repeating of the layer production steps. This makes it possible through alteration of a height of the respective layer bodies in the vertical direction to form further different surface topologies.
[0067] As a manufacturing parameter it is further possible to alter the dimensions of the pixels reflected by the micromirrors M of the micromirror unit 6 via the imaging unit O during the repeating of the layer production steps. This makes it possible to further alter the surface topologies.
[0068]
[0069] For example a 3-D body having the stepped structure shown in
[0070] According to the present invention this side effect can be utilized in such a way that an illumination parameter is altered (for example increased) such that during selective irradiation (8) for crosslinking of a respective layer body the photopolymerizable residual material R remaining in the corners and/or edges of the transirradiation side of the stepped structure (9) is irradiated through a layer body disposed therebelow (for example S5) and is likewise converted into photopolymerized/crosslinked residual material (R->R). By contrast, the residual material R remaining on the incident light-side stepped structure (10) is not irradiated (micromirrors M reflect the light into the absorber A), as a result of which no polymerization/crosslinking of the residual material R occurs in this region. This uncrosslinked residual material may be partially or completely removed in the subsequent cleaning.
[0071] As per
[0072] An irradiation parameter that may be changed for example is an irradiation intensity, wherein an energy input of the radiation into the respective lowermost layer bodies S5 (to be formed) is increased such that the photopolymerizable residual material R disposed thereabove is also (trans) irradiated. As a result, not only the layer body S5 that is actually to be formed but also residual material in a layer plane disposed thereabove is polymerized/crosslinked, with the result that after a cleaning step the depicted smoothing of the transirradiation-side stepped structure 9 is attained. However, since no irradiation from below is performed in the region of the incident light-side stepped structure 10, no postcrosslinking of the photopolymerizable residual material R takes place on this side, with the result that after a cleaning step a very sharp-edged surface topology is formed on the incident light side. By way of example the irradiation intensity may be increased by a factor of 1.5 to 2.5 relative to an irradiation intensity normal for a predetermined layer thickness.
[0073] Alternatively or in addition it is possible to increase the irradiation parameter irradiation time, wherein an energy input of the radiation into the lowermost layer body S5 (to be formed) is in turn increased such that the residual material R disposed thereabove is also (trans) irradiated. As a result, not only the layer body S5 that is actually to be formed but also photopolymerizable residual material in a layer disposed thereabove is polymerized/crosslinked, with the result that the depicted smoothing is attained on the transirradiation-side stepped structure 9 on account of the polymerized residual material R. No irradiation from below is in turn performed in the region of the incident light-side stepped structure 10, as a result of which no postcrosslinking of the polymerizable residual material R takes place on this side and (for example in the case of a cleaning of the uncrosslinked residual material R removed) a very sharp-edged surface topology is formed. By way of example the irradiation time may be increased by a factor of 1.5 to 3.5, preferably a factor of 2, relative to an irradiation time normal for a predetermined layer thickness.
[0074] Alternatively or in addition it is furthermore possible to alter a wavelength of the radiation used to increase an energy input and realize the effect described hereinabove.
[0075] Although the present application often refers to light in respect of the irradiation parameters it will be appreciated that any type of electromagnetic radiation (also including for example invisible light, x-rays etc.) may be used for the selective irradiation.
[0076] This first exemplary embodiment accordingly makes it possible to form different surface topologies on opposite sides of a 3D body/monolithic component in individual surface regions in particularly simple fashion and especially simultaneously through specific variation of irradiation parameters.
[0077]
[0078] As per
[0079] The joint implant preferably has a length of at least 0.6 cm and at most 1.2 cm for patellar applications and applications in small joints such as for example the wrist or ankle and at least 0.8 cm and at most 2.2 cm, in particular 1.0 cm to 1.6 cm and more preferably 1.25 cm for respective proximal and distal tibial and femural application in the knee and hip joints. This makes it possible to achieve optimal accessibility and ingrowth of mesenchymal stem cells. The joint implant according to
[0080] A network structure of the artificial trabecular structure which is defined, repetitive and based on the natural trabecular structure or a channel structure with an appropriately adapted shape of the joint implant, in particular in conjunction with the above-described process for forming different surface topologies in specifically selected regions, makes it possible to achieve optimal ingrowth of endogenous tissue into the boundary volume between the joint implant and a depression/bore channel, in particular into the internal volume of the joint implant and above the end of the joint implant facing the synovia.
[0081] According to the invention a joint implant may thus in particular have a hydrophobic and thus chondroblastic differentiation-favouring surface in its top region and upper shell region while the bottom region and the lower part of the shell region have a hydrophilic surface to favour an osteoblastic differentiation of mesenchymal stem cells. This makes it possible to favour cartilage growth in the upper region of the joint implant (facing the synovia) and bone growth in the lower region of the joint implant (facing the bone marrow space).
[0082] It is alternatively possible to produce technical functional bodies, for example catalysts, capacitors, membranes etc., as such monolithic components having locally different surface properties. On account of a selectively adjustable wetting behaviour technical functional bodies (3-D bodies) can thus be coated specifically and only for defined regions, for example with electrically conductive material, with catalytically active material, with wear-resistant material, with sensor material, with capacitor material etc. Highly complex and very small functional bodies are thus producible at relatively low cost for the first time.
[0083] It is noted that each step of the process described hereinabove may be implemented by computer program commands. These computer program commands may be loaded onto a computer or another programmable device to produce an apparatus, wherein the commands executed in the computer or another programmable device produce means for implementing the functionalities as described in the process steps. These computer program commands may likewise be stored on a digital storage medium, for example a DVD, CD or diskette comprised by a computer or other programmable device for realizing a certain functionality. Furthermore, the computer program commands/the program code may be downloaded for example from a telecommunications network to bring about operating steps which are implemented on a computer or another programmable device to produce a computer-implemented process which makes it possible to perform the process steps.
[0084] The invention thus further comprises a digital storage medium with electronically readable control signals which can interact with a computer system such that they can execute the described process steps. The invention further relates to a computer program product comprising program code stored on a machine-readable storage medium for performing the described process steps when the program is executed on a computer. The present invention further relates to a computer program comprising program code for performing the process steps described hereinabove when the program is executed on a computer.
[0085] The invention was described hereinabove with reference to preferred exemplary embodiments. However, said invention is not limited thereto and in particular also comprises combinations of the above-described exemplary embodiments. In particular, an irradiation may also be effected via lasers instead of the micromirror unit. It is also possible to employ other additive 3D printing processes instead of the described lithography process.
LIST OF REFERENCE NUMERALS
[0086] 1 photopolymerizable material [0087] 2 tray bottom [0088] 3 smoothing element [0089] 4 platform [0090] 5 irradiation unit [0091] 6 micromirror unit [0092] 7 monolithic component (green body) [0093] 8 selective irradiation [0094] 9 transirradiation-side stepped structure [0095] 10 incident light-side stepped structure [0096] 11 pixel field [0097] 12 lifting mechanism [0098] S1-S5 layer body [0099] M micromirror [0100] L light source [0101] A absorber [0102] P pixel [0103] O optical imaging unit [0104] E design element [0105] O.sub.M design element surface [0106] B component element [0107] O.sub.B component element surface [0108] R photopolymerizable residual material [0109] R photopolymerizable residual material [0110] X, Y horizontal build space orientation (micromirror principal axes) [0111] X.sub.M, Y.sub.M, Z.sub.M design element orientation [0112] Z vertical build space orientation (perpendicular to tray bottom) [0113] ? rotation angle [0114] ?.sub.x tilting angle in x-direction [0115] ?.sub.y tilting angle in y-direction [0116] B.sub.11-B.sub.44 components produced with tilting