Abstract
A tray for positioning, in a fixed positional relationship, a medical vial 7 together with a vial adapter 4 is disclosed. A tray member 10 includes a vial accommodation cavity 11 and a vial adapter accommodation cavity 12, each comprises retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b configured to position the vial adapter 4 and the vial 7 spaced apart from each other and in axial alignment in an intermediate position. The retaining members 19, 37a, 37b, 35a, 35b, 36a, 36b are further configured to guide a relative axial movement of the vial 7 and vial adapter 4 from the intermediate position to a transfer position while maintaining the axial alignment of the vial 7 with the vial adapter 4. In the transfer position the vial adapter 4 is locked to the vial 7 and a piercing mandrel 57 pierces a vial stopper 76 for liquid transfer.
Claims
1. A tray (1) for positioning a vial (7) for medical or pharmaceutical applications together with a vial adapter (4) in a fixed positional relationship relative to each other, said vial adapter (4) comprising a piercing mandrel (57) and being configured to be locked to a front end of the vial (7) in a transfer position in which the piercing mandrel (57) pierces a stopper (76) of the vial (7) for transfer of a liquid out of and/or into the vial (7), said tray (1) comprising: a tray member (10) having a planar upper surface (10a), a vial cavity (11) for accommodating at least a portion of the vial (7) and a vial adapter cavity (12) for accommodating at least a portion of the vial adapter (4), wherein the vial cavity (11) and vial adapter cavity (12) is each open toward the planar upper surface (10a), the vial adapter cavity (12) and the vial cavity (11) each comprises retaining members (19; 17, 22, 25; 37a, 37b, 35a, 35b, 36a, 36b), which are formed integrally with a side-wall of the vial cavity (11) and vial adapter cavity (12), respectively, wherein the retaining members (19; 17, 22, 25; 37a, 37b, 35a, 35b, 36a, 36b) are configured a) to position the vial adapter (4) and the vial (7) in an intermediate position, in which the vial adapter (4) is positioned in a fixed position and predetermined orientation while the vial (7) is positioned spaced apart from the vial adapter (4) and in axial alignment with the vial adapter (4), and b) to guide a relative movement of the vial (7) and vial adapter (4) from the intermediate position to the transfer position while maintaining the axial alignment of the vial (7) and vial adapter (4) with each other.
2. The tray as claimed in claim 1, wherein the planar upper surface (10a) encircles the vial cavity (11) and vial adapter cavity (12).
3. The tray as claimed in claim 1, wherein the retaining members comprise pairs of protrusions (19, 37a, 37b, 35a, 35b, 35c, 36a, 36b) formed on opposite side-walls (21, 24, 17a) of the vial adapter cavity (12) and vial cavity (11), respectively, which are configured for contacting side-surfaces of the vial adapter (4) and vial (7), respectively, for positioning the vial adapter (4) and the vial (7).
4. The tray as claimed in claim 3, wherein a height (h2) of contact regions (80) of the protrusions (19, 37a, 37b, 36a, 36b) with the side-surfaces of the vial adapter (4) and vial (7), respectively, above a bottom (22, 25, 17) of the vial adapter cavity (12) and vial cavity (11), respectively, is larger than the height of a center line (CL) of the vial adapter (4) and vial (7) above the bottom (22, 25, 17) of the vial adapter cavity (12) and vial cavity (11).
5. The tray as claimed in claim 3, wherein the opposite side-walls (21, 24, 17a) on which the protrusions (19, 37a, 37b, 35a, 35b, 36a, 36b) are formed are each upright and planar side-walls.
6. The tray as claimed in claim 3, wherein the vial cavity (11) comprises at least two pairs of protrusions (36a, 36b) formed on opposite side-walls (21, 24, 17a) of the vial cavity (11), and at least one pair of protrusions (36b) is still in contact with side-surfaces of the vial (7) in the transfer position.
7. The tray as claimed in claim 1, said tray member (10) further comprising guiding protrusions (37a, 37b, 36a, 36b) for maintaining the axial alignment between the vial (7) and vial adapter (4) during the relative movement between the vial (7) and the vial adapter (4) in the cavities (11, 12) from the intermediate position to the transfer position.
8. The tray as claimed in claim 1, wherein a bottom (17) of the vial cavity (11) is curved with a radius of curvature corresponding to an outer radius of a vial body (70) of the vial (7) and the profile of a bottom (22, 25) of the vial adapter cavity (12) corresponds to an outer profile of the vial adapter (4).
9. The tray as claimed in claim 1, wherein the vial cavity (11) further comprises axial position limiting members (35a, 35b) configured for delimiting an axial movement of the vial (7) inside the vial cavity (11) in the storage position.
10. The tray as claimed in claim 9, wherein the axial position limiting members (35a, 35b) are more flexible than the retaining members (36a, 36b) of the vial cavity (11).
11. The tray as claimed in claim 1, wherein the vial adapter cavity (12) is configured to keep the vial adapter (4) at a fixed axial position inside the vial adapter cavity (12) and the retaining members of the vial cavity (11) are configured to guide an axial movement of the vial (7) toward the vial adapter (4) from the intermediate position to the transfer position while maintaining the axial alignment of the vial (7) and vial adapter (4) with each other.
12. The tray as claimed in claim 11, wherein the vial adapter (4) has a stepped outer contour and the vial adapter cavity (12) comprises a plurality of cavities (18, 21, 24) of different widths and a plurality of stop surfaces (19, 20, 23) that delimit an axial displacement of the vial adapter (4) away from the vial (7) by abutment with the stepped outer contour of the vial adapter (4).
13. The tray as claimed in claim 1, wherein the tray member (10) further comprises an intermediate cavity (13, 15) formed between the vial adapter cavity (12) and the vial cavity (11), wherein a bottom end (64) of the vial adapter (4) is spaced apart from the front end of the vial (7) in the intermediate position.
14. The tray as claimed in claim 13, wherein the intermediate cavity comprises a portion (15) that is sufficiently wide to enable access to a vial body (70) of the vial (7) by means of fingers of a user or grippers of a robot in the intermediate position for driving the relative movement of the vial (7) and vial adapter (4) and/or for removal of the vial (7) together with the vial adapter (4) locked to the front end of the vial (7) in the transfer position from the tray member (10).
15. The tray as claimed in claim 1, wherein the tray member (10) further comprises a rear end cavity (14), where a bottom (71) of the vial (7) is sufficiently exposed to enable access to the bottom (71) for a finger of a user or a manipulation member of a robot for driving the axial movement of the vial (7) from the intermediate position to the transfer position.
16. The tray as claimed in claim 1, wherein the tray member (10) is made of plastic material and wherein the retaining members (19, 37a, 37b, 35a, 35b, 35c, 36a, 36b) are formed integrally with the tray member (10).
17. The tray as claimed in claim 16, wherein the tray member (10) is made by vacuum thermoforming or pressure thermo-forming of a plastic sheet or by means of plastic injection molding.
18. The tray as claimed in claim 1, wherein the tray member (10) is made of paper or cardboard, and wherein the retaining members (19, 37a, 37b, 35a, 35b, 35c, 36a, 36b) are formed integrally with the tray member (10).
19. The tray as claimed in claim 18, wherein a thin film of plastic or bioplastic is arranged on inner surfaces of the vial adapter cavity (12) and vial cavity (11).
20. The tray as claimed in claim 1, wherein the tray member (10) comprises a vial adapter tray member (100) having a vial adapter storage cavity (101) for long-time storage of the vial adapter (4), wherein the vial adapter storage cavity (101) and the vial adapter cavity (12) is each configured for enabling a transfer of the vial adapter (4) from the vial adapter storage cavity (101) into the vial adapter cavity (12) to position the vial adapter (4) in the intermediate position.
21. The tray as claimed in claim 20, wherein the vial adapter tray member (100) is connected with the tray member (10) via a hinge (102) so that the vial adapter tray member (100) can be pivoted about the hinge (102) for positioning the vial adapter storage cavity (101) vertical above the vial adapter cavity (12) for enabling a transfer of the vial adapter (4) from the vial adapter storage cavity (101) into the vial adapter cavity (12) to position the vial adapter (4) in the intermediate position.
22. The tray as claimed in claim 20, wherein the vial adapter tray member is a tray member insert (100) that includes the vial adapter cavity (12) and the tray member (10) comprises a positioning cavity (12a), wherein the tray member insert (100) is configured to be inserted into the positioning cavity (12a) of the tray member (10) as an independent member, and wherein when the tray member insert (100) is inserted into the positioning cavity (12a) of the tray member (10), the vial adapter (4) is positioned in the intermediate position.
23. The tray as claimed in claim 22, wherein the tray member insert (100) comprises locking means (103) for locking the tray member insert (100) to the tray member (10), for positioning the tray member insert (100) in the positioning cavity (12a) of the tray member (10).
24. A packaging unit (9) for packaging a vial (7) for medical or pharmaceutical applications together with a vial adapter (4), said vial adapter (4) comprising a piercing mandrel (57) and being configured to be locked to a front end of the vial (7) in a transfer position in which the piercing mandrel (57) pierces a stopper (76) of the vial (7) for transfer of a liquid out of and/or into the vial (7), said packaging unit (9) comprising a tray (1) for positioning the vial (7) together with the vial adapter (4) in a fixed positional relationship relative to each other, and a packaging foil (8, 8a), wherein the tray (1) comprises a tray member (10) having a planar upper surface (10a), a vial cavity (11) for accommodating at least a portion of the vial (7) and a vial adapter cavity (12) for accommodating at least a portion of the vial adapter (4), wherein the vial cavity (11) and vial adapter cavity (12) is each open toward the planar upper surface (10a), and the vial adapter cavity (12) and the vial cavity (11) each comprises retaining members (19; 17, 22, 25; 37a, 37b, 35a, 35b, 36a, 36b), which are formed integrally with a side-wall of the vial cavity (11) and vial adapter cavity (12), respectively, configured to position the vial adapter (4) and the vial (7) in an intermediate position, in which the vial adapter (4) is positioned in a fixed position and predetermined orientation while the vial (7) is positioned spaced apart from the vial adapter (4) and in axial alignment with the vial adapter (4) and to guide a relative movement of the vial (7) and vial adapter (4) from the intermediate position to the transfer position while maintaining the axial alignment of the vial (7) and vial adapter (4) with each other, wherein the vial adapter (4) is accommodated in the vial adapter cavity (12), the vial (7) is accommodated at least partially in the vial cavity (11) spaced apart from the vial adapter (4), and the tray member (10) is sealed against the environment by the packaging foil (8, 8a).
25. The packaging unit (9) as claimed in claim 24, wherein the packaging foil (8, 8a) is adhesively bonded to the upper surface of the tray member (10).
26. The packaging unit (9) as claimed in claim 24, wherein the tray member (10) comprises a vial adapter tray member (100) having a vial adapter storage cavity (101) for long-time storage of the vial adapter (4), and wherein the vial adapter storage cavity (101) is sealed by a second packaging foil (8a).
Description
OVERVIEW ON DRAWINGS
[0042] The invention will now be described by way of example and with reference to the accompanying drawings, from which further features, advantages and problems to be solved will be-come apparent. In the drawings:
[0043] FIGS. 1a and 1b show an example of a vial adapter for use in a tray according to the present invention in a schematic side-view and cross-section, respectively;
[0044] FIG. 1c shows another example of a vial adapter for use in a tray according to the present invention in a schematic side-view;
[0045] FIGS. 2a to 2d show a tray according to a first embodiment of the present invention in a perspective top view, in a perspective bottom view, in a plan view and in a side-view;
[0046] FIG. 3a shows a tray according to the present invention in a perspective top view, with a vial adapter accommodated in a vial adapter cavity of the tray and a vial accommodated in a vial cavity of the tray in a storage position that both coincide with the intermediate position;
[0047] FIG. 3b shows the tray of FIG. 3a in a perspective top view, with the vial displaced in axial direction towards the vial adapter, shortly before the piercing mandrel of the vial adapter pierces the vial stopper;
[0048] FIG. 3c shows the tray of FIG. 3a in a perspective top view, with the vial displaced from the position of FIG. 3b further in axial direction towards a transfer position, in which the piercing mandrel of the vial adapter pierces the vial stopper for liquid transfer;
[0049] FIG. 3d shows the tray of FIG. 3a in a perspective top view, with the assembly consisting of the vial and vial adapter locked to each other in the transfer position and removed from the cavities of the tray;
[0050] FIG. 4a shows in a schematic cross-section a tray according to the present invention together with a vial adapter and vial accommodated in cavities of the tray in the storage position of FIG. 3a, which coincides with an intermediate position;
[0051] FIG. 4b shows in a schematic cross-section the tray of FIG. 4a together with the vial adapter and vial accommodated in cavities of the tray in the position of FIG. 3b;
[0052] FIG. 4c shows in a schematic cross-section the tray of FIG. 4a together with the vial adapter and vial accommodated in cavities of the tray in the transfer position of FIG. 3c;
[0053] FIG. 5a shows in an enlarged plan view the vial adapter of FIG. 1a accommodated in a vial adapter cavity of a tray according to the present invention;
[0054] FIG. 5b is a perspective top view of the vial adapter of FIG. 1a accommodated in a vial adapter cavity of a tray according to the present invention;
[0055] FIG. 5c shows a schematic cross-section of the tray along A-A of FIG. 4c;
[0056] FIG. 5d shows a schematic cross-section of the tray along A-A of FIG. 4c, but viewed in the opposite direction of FIG. 5c;
[0057] FIG. 5e is a schematic partial side-view showing a vial and vial adapter accommodated in the cavities of a tray according to the present invention in the intermediate position of FIG. 3a;
[0058] FIGS. 6a-6c show a tray according to a second embodiment of the present invention in a perspective top view, in a bottom view, and in a side-view;
[0059] FIG. 7a shows a sterile packaging unit with a tray according to a third embodiment of the present invention in a position used for long-time storage of the vial and vial adapter;
[0060] FIG. 7b shows the packaging unit of FIG. 7a after removal of a first packaging foil;
[0061] FIG. 7c shows the vial adapter cavity of the tray of FIG. 7a, which is sterile sealed by a second packaging foil;
[0062] FIG. 7d shows the packaging unit of FIG. 7a after removal of the first and second packaging foil with the vial adapter and the vial positioned in the intermediate position;
[0063] FIG. 8a shows a sterile packaging unit with a tray according to a fourth embodiment of the present invention in a position used for long-time storage of the vial and vial adapter;
[0064] FIG. 8b shows the packaging unit of FIG. 8a after removal of a first packaging foil;
[0065] FIG. 8c shows the packaging unit of FIG. 8a after removal of a second packaging foil;
[0066] FIG. 8d shows the packaging unit of FIG. 8a in a position, in which the vial adapter storage cavity is positioned vertical above the vial adapter cavity and before the transfer of the vial adapter from the vial adapter storage cavity into the vial adapter cavity;
[0067] FIG. 8e shows the packaging unit of FIG. 8a in a position, in which the vial adapter storage cavity is positioned vertical above the vial adapter cavity and after the transfer of the vial adapter from the vial adapter storage cavity into the vial adapter cavity, with the vial adapter positioned in the intermediate position;
[0068] FIG. 8f shows the packaging unit of FIG. 8a in a position enabling the displacement of the vial towards the vial adapter from the intermediate position to the transfer position;
[0069] FIG. 9 shows a modification of the packaging unit of FIG. 8a;
[0070] FIG. 10a shows a tray member insert including a vial adapter storage cavity for long-time storage of a vial adapter under sterile conditions; and
[0071] FIG. 10b is a perspective exploded top view of a packaging unit including a tray according to a fifth embodiment of the present invention and including the tray member insert of FIG. 10a.
[0072] In the drawings, the same reference numerals designate identical or substantially equivalent elements or groups of elements.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
[0073] FIGS. 1a and 1b show an example of a vial adapter for use in a tray according to the present invention in a schematic side-view and cross-section, respectively. The vial adapter 4 has a generally stepped outer contour consisting of a first cylindrical portion 48, a second cylindrical portion 50 and a third cylindrical portion 60. A first step 51 is formed between the two cylindrical portions 48 and 50 and a second step 54 is formed between the cylindrical portions 50 and 60. The outer diameters of the cylindrical portions 48, 50 and 60 are different and increase from the front end 44 to the bottom end 64.
[0074] The vial adapter 4 consists basically of a valve body 40 and a coupling body 42. The valve body 40 includes a valve of the type disclosed in U.S. Pat. No. 6,651,956 B2, the whole content of which is hereby incorporated by reference. The valve stem 46 is accommodated in the cavities of the first and second cylindrical portion 48, 50 and abuts against the conical portion 49 and the bottom of cavity formed by the cylindrical wall 53 of the connecting ring 41, which connects the valve body 40 to the locking body 60, e.g. by bonding or ultrasonic welding. A slit is formed in the front end of the elastomeric valve member 45, which is exposed in the front opening 44 of the first cylindrical portion 48. An outer thread 43 on the first cylindrical portion 48 enables the coupling with a Luer thread of a syringe. When a syringe is coupled to the first cylindrical portion 48 by threading, the tip of the syringe will penetrate the slit and enter the central channel 47 of the valve member 45 for liquid transfer.
[0075] The coupling body 42 of the vial adapter 4 is configured to be locked to the front end of a vial in a transfer position, such as of the general configuration disclosed e.g. in U.S. Pat. No. 8,752,598 B2. The coupling body 42 includes a skirt 60 consisting of a plurality of curved segments that are disposed along the circumference of the skirt 60 at equiangular intervals and interrupted by axial slots 62. The segments form resilient legs 61 that can be flexed radially outwards. On the inner surfaces of the resilient legs 61 locking protrusions 63 are formed. The coupling body 42 includes a top wall 55 with a central piercing mandrel 57 that comprises a central cannula or lumen 58 that is in fluid communication with the central channel 47 of the valve member 45 via the mouth 58a.
[0076] When the vial adapter 4 is pushed onto the front end of a vial of the kind shown in FIG. 4a, the bottom bevels of the protrusions 63 will finally slide along the outer edge of the metal cap 77 crimped onto the front end of the vial and thus start spreading the resilient legs 61 apart. When the vial adapter 4 is pushed further onto the front end of a vial, the resilient legs will continue to be spread apart and finally the piercing mandrel 57 will start piercing or puncturing the elastomeric stopper 76 sealing the opening at the front end of the vial. When the vial adapter 4 is pushed further onto the front end of a vial, finally the protrusions 63 will grip behind the bottom edge of the metal cap 77 of the vial and the piercing mandrel 57 will have fully penetrated or punctured the vial stopper 76, thus enabling a liquid transfer into and/or out of the vial in the transfer position shown in FIG. 4c.
[0077] The general shape of a vial to be accommodated in a tray according to the present invention is shown in the cross-sectional view of FIG. 4a. The vial 7 has a cylindrical vial body 70 with a closed bottom 71 and a conical shoulder 73 that is followed by a narrow neck 74 and a wider rolled edge 75 that defines a filling opening of the vial 7. This filling opening is sealed by an elastomeric stopper 76 that is held in place by a cylindrical metal cap 77 that is crimped over the rolled edge 75. A circular central opening 78 is defined in the upper surface of the metal cap 77 and exposes a central portion of the stopper 76 that will be pierced or punctured by the piercing mandrel 57 of the vial adapter 4 in the transfer position shown in FIG. 4c, when a vial adapter 4 is locked on the front end of the vial 7. The cylindrical shape of such a vial 7 precisely defines a center line.
[0078] For storing a vial adapter 4 in a fixed positional relationship relative to such a vial that enables the establishment of the transfer position (when the vial adapter 4 is locked on the front end of a vial 7) by means of a relative movement of the vial adapter 4 and vial 7 only in axial direction, according to the present invention a tray 1 as shown in FIGS. 2a to 2d is used. The tray 1 comprises a tray member 10 comprising at least a vial cavity 11 for accommodating a vial (not shown) at least partially and a vial adapter cavity 12 for accommodating a vial adapter (not shown) at least partially. The tray member 10 preferably has a planar upper surface 10a so that a packaging or sealing foil, in particular a sterile packaging or sealing foil, may be bonded onto the upper surface 10a, for sealing, if this should be necessary, a vial and a vial adapter in the cavities of the tray member 10, preferably under sterile conditions. As shown in FIG. 2a, the tray member 10 may include additional cavities 13 to 15 enabling additional functions, as outlined below in more detail.
[0079] As shown in FIG. 2a, the vial adapter cavity 12 may have a stepped inner profile corresponding to the stepped outer contour of the vial adapter to be accommodated in the vial adapter cavity 12 to thereby keep the axial position of the vial adapter fixed. Assuming for this example that a vial adapter of the general shape shown in FIGS. 1a and 1b is to be accommodated in the vial adapter cavity 12, it may thus include a first relatively narrow cavity 18 for accommodating the first cylindrical protrusion 48 of the vial adapter 4, a second cavity 21, which is a little wider than the first cavity 18, for accommodating the second cylindrical protrusion 50 of the vial adapter 4, and a third cavity 24, which is a little wider than the second cavity 21, for accommodating the coupling body 40 of the vial adapter 4.
[0080] FIGS. 5a and 5b show how the vial adapter 4 of FIGS. 1a and 1b is accommodated in such a vial adapter cavity. When an axial force is exerted onto the vial adapter 4 towards its front end (e.g. as a result of pushing a vial towards the vial adapter for establishing the transfer position), the front end of the first cylindrical protrusion 48 of the vial adapter 4 will abut against the upright front wall 19 of the first cavity 18 so that the position of the vial adapter 4 in axial direction is fixed and precisely defined at least by the front wall 19. As can be concluded from FIGS. 5a and 5b, the position of the vial adapter 4 in axial direction may additionally be fixed or defined by abutment of the upper surface of the second cylindrical protrusion 50 against the first stop surface 20 and of the upper surface of the coupling body 42 against the second stop surface 23. In the intermediate position that will be explained hereinafter in more detail, the vial adapter 4 may be fully accommodated in the cavities of the vial adapter cavity 12.
[0081] As shown in FIGS. 5a and 5b, the bottom end of the skirt 60 of the coupling body 40 may also extend into an additional cavity 16 (hereinafter also named second lateral cavity 16) provided in the tray member 10, which has a larger diameter than the third cavity 24 of the vial adapter cavity 12 and thus exposes the bottom end of the skirt 60 of the coupling body 40 a little, so that the resilient legs 61 may flex more easily and unhindered radially outward when coupling body 42 begins to be locked onto the front end of a vial. For this purpose, the bottom end of the skirt 60 preferably does not up to the bottom of the widened second lateral cavity 16. The second lateral cavity 16 may also serve to ease insertion of the vial adapter 4 from vertically above into the vial adapter cavity 12, e.g. by means of the fingers of a user or grippers of a robot.
[0082] As shown in FIG. 2a, the bottoms 18a, 22, 25 of the cavities 18, 21, 24 of the vial adapter cavity 12 are curved, with a radius of curvature corresponding to the outer radius of the corresponding cylindrical portion 48, 50, 42 of the vial adapter 4 to be accommodated therein. The cylindrical portion 48, 50, 42 may serve for positioning the vial adapter in a direction perpendicular to the axial direction of the vial adapter. As shown in FIG. 2a, the upper side-walls 18b, 22a, 25a of the cavities 18, 21, 24 of the vial adapter cavity 12 may be planar and extend perpendicular to the upper surface 10a of the tray member 10.
[0083] As shown in FIGS. 2a and 2d, a pair of front retaining members 37b is formed on the opposite upper side-walls 22a of the second cavity 21 to retain the vial adapter in the vial adapter cavity 12 in axial direction. The front retaining members 37b may also serve for keeping the vial adapter 4 pushed downward toward the bottom of the vial adapter cavity 12 in the intermediate position. Additionally, or as an alternative, a second pair of rear retaining members 37a may be formed on the opposite upper side-walls 24a of the third cavity 24 to retain the vial adapter in the vial adapter cavity 12 in axial direction. The second pair of rear retaining members 37a may also serve for keeping the vial adapter 4 pushed downward toward the bottom of the vial adapter cavity 12 in the intermediate position. To enable an unhindered flexure of the resilient legs 61 of the coupling body 40 in the widened second lateral cavity 16, the rear retaining members 37a extend only along the upper portion of the coupling body 40.
[0084] As shown in FIG. 5c, the retaining members 37a, 37b are preferably formed integrally with the upper side-walls 22a, 25a of the cavities 21, 24 of the vial adapter cavity 12. More specifically, the retaining members 37a, 37b may be formed as convexly curved protrusions protruding from the upper side-walls 22a, 25a of the cavities 21, 24 at a height that is larger than the height h1 of a center line CL of the vial adapter 4 above the bottom of the vial adapter cavity 12. Thus, a certain force component always prevails to push the vial adapter 4 towards the bottom of the vial adapter cavity 12 when accommodated therein in the intermediate position. When a vial adapter 4 is inserted from above into a vial adapter cavity 12 for storage or in preparation to establish the transfer position by axial displacement, the vial adapter 4 will be locked by the retaining members 37a, 37b in the vial adapter cavity 12 at least in a direction perpendicular to the center line CL of the vial adapter, to thereby define an orientation of the vial adapter 4 in parallel with the bottom of the vial adapter cavity 12 and to define the level h1 of the center line CL in the intermediate position. As shown in FIG. 5c, when the vial adapter 4 is accommodated in the vial adapter cavity 12, it preferably does not protrude beyond the upper surface 10a of the tray member 10 so that the vial adapter cavity can be sealed by bonding a sealing foil on the upper tray surface 10a. Locking of the vial adapter 4 by the retaining members 37a, 37b in the vial adapter cavity 12 may also be sufficient to define the position of the vial adapter 4 in axial direction.
[0085] As shown in FIG. 2a, the tray member 10 further comprises a vial cavity 11 for accommodating a vial (not shown) spaced apart from the vial adapter and in axial alignment with the vial adapter in the intermediate position. The term ‘spaced apart’ means that in the intermediate position, which will be explained hereinafter in more detail, the piercing mandrel 57 of the vial adapter 4 is not yet in contact with the upper surface of the stopper of the vial 7, which means that a certain gap exists between the bottom end of the skirt 60 and the metal cap 77 of the vial 7, as shown in FIG. 3a. In the intermediate position, the side surface of the metal cap 77 of the vial 7 may extend slightly into an intermediate cavity 13 provided between the vial adapter 12 and the vial cavity 11. The width of the intermediate cavity 13 may correspond to the outer diameter of the metal cap 77 so that the vial 7 is additionally guided by the side-walls 27 of the intermediate cavity 13 in the final stage of the piercing mandrel 57 piercing the stopper of the vial. Of course, the width of the intermediate cavity 13 may also be a little larger than the outer diameter of the metal cap 77.
[0086] As shown in FIG. 2a, the vial cavity 11 may have an inner profile corresponding to the outer contour of the vial body 70 (cf. FIG. 3a) of the vial to be accommodated in the vial cavity 11. More specifically, the vial cavity 11 may have a curved bottom having a radius of curvature that corresponds to the outer radius of the vial body 70. As shown in FIGS. 2a and 2d, the upper side-walls 17a of the vial cavity 11 may be planar and extend perpendicular to the upper surface 10a of the tray member 10. As shown in FIGS. 2a and 2d, a pair of front vial retaining members 36b is formed on the opposite upper side-walls 17a of the vial cavity 11 to retain the vial in the vial cavity 11 in the intermediate position. The front vial retaining members 36b may also serve to push the vial body downward toward the bottom 17 of the vial cavity 11 to define the height of the center line of the vial in the intermediate position. Additionally, a second pair of rear vial retaining members 36a may be formed on the opposite upper side-walls 17a of the vial cavity 11 to retain the vial adapter in the vial cavity 11 in the intermediate position. The rear vial retaining members 36a may also serve to push the vial body downward toward the bottom 17a of the vial adapter cavity 11 to define the height of the center line of the vial in the intermediate position.
[0087] As shown in FIG. 5d, the retaining members 36a, 36b are preferably formed integrally with the upper side-walls 17a of the vial cavity 11. More specifically, the retaining members 36a, 36b may be formed as convexly curved protrusions protruding from the upper side-walls of the vial cavity at a height h2 that is larger than the height h1 of a center line CL of the vial body 70 above the bottom 17 of the vial cavity 11. Thus, a certain force component always may prevail to push the vial body 70 towards the bottom 17 of the vial cavity 11 when accommodated therein in the intermediate position. When a vial 7 is inserted from above into a vial cavity 11 for storage or positioning, the vial 7 will be locked by the retaining members 36a, 36b in the vial cavity 11 at least in a direction perpendicular to the center line CL of the vial body 70, to thereby define an orientation of the vial 7 in parallel with the bottom of the vial cavity 11 and in axial alignment with the vial adapter accommodated in the vial adapter cavity in the intermediate position. As shown in FIGS. 5c and 5d, when the vial body 70 is accommodated in the vial cavity 11, it may not protrude beyond the upper surface 10a of the tray member 10 so that the vial cavity 11 may be sealed by a packaging foil bonded on the upper surface of the tray member 10. Locking of the vial body 70 by the retaining members 36a, 36b in the vial cavity 11 may also be sufficient to define the position of the vial in axial direction.
[0088] As shown in FIG. 2d, movement limiting protrusions 35a, 35b may be provided in the vial cavity 11 near the rear end of the vial cavity 11 and near the position of the transition between the vial body 70 and the vial shoulder 73 (see FIG. 3a), for defining the position of the vial in axial direction even more precisely by abutment of protrusions in the vial cavity 11 with the bottom and shoulder of the vial, respectively. Moreover, additional movement limiting protrusions 35c may be provided on the side surfaces of the vial adapter cavity 11, in particular at the front end thereof.
[0089] As shown in FIG. 4a, the vial body 70 may be accommodated in the vial cavity 11 in the storage position with a certain play in axial direction, but the vial body 70 may also be accommodated in the vial cavity 11 in the storage position without play in axial direction. The movement limiting protrusions 35a, 35b and 35c may be formed integrally with the bottom or side-walls of the vial cavity 11, and are preferably formed in the bottom 17 of the vial cavity 11, as shown in FIG. 2d. The movement limiting protrusions 35a, 35b, 35c may be formed as convex bulges protruding a little into the vial cavity 11. The rear movement limiting protrusion 35a may be U-shaped to extend along the entire rear end of the vial cavity 11, as shown in FIG. 2a. As the vial body 70 will slide over the front movement limiting protrusion 35b on its way towards the transfer position, the front movement limiting protrusion 35b may be relatively shallow and thin so that it can be pressed down easily by the vial body 70. As shown in FIGS. 2a and 2d, the front movement limiting protrusion 35b may be disposed in the region of the intermediate cavity 13.
[0090] FIGS. 2b and 2c show the tray 1 in a perspective bottom view and side view, respectively. The tray member 10 is preferably made of plastic material, in particular by vacuum thermoforming or pressure thermo-forming of a thin plastic sheet or by means of plastic injection molding, and preferably all of the retaining and movement limiting members 19, 37a, 37b, 35a, 35b, 35c, 36a, 36b are formed integrally with the tray member 10. Any other materials may be used as well, however. In particular, the tray member may also be made of paper or cardboard. A thin film of plastic or bioplastic may be arranged on inner surfaces of the vial adapter cavity 12 and vial cavity 11 to enable even the storage of the vial adapter and vial in the cavities 11, 12 under sterile conditions. DE 102011122211 A1 discloses an example of such a compound packaging material including a substrate made of paper or cardboard that is coated by a thin film of plastic or bioplastic, and the whole contents of DE 102011122211 A1 is hereby incorporated by reference.
[0091] FIG. 3a shows a packaging unit 9 according to the present invention, consisting of a tray 1 that stores a vial adapter and a vial in the manner outlined above and is sealed by a packaging foil 8. The packaging foil 8 may seal the whole tray together with the vial adapter and vial in a sterile manner against the environment. For this purpose, the packaging foil 8 may be adhesively bonded onto the planar upper surface of the tray 1. As an alternative the tray 1 may be accommodated in a sealed pouch formed by the packaging foil 8. The packaging foil 8 may be gas-permeable, in particular a Tyvek®-foil, to enable a steam sterilization of the tray 1, vial and vial adapter by a gas flowing through the packaging foil 8.
[0092] FIG. 3a shows the packaging unit with the vial and vial adapter positioned in an intermediate position in which the vial adapter is positioned inside the vial adapter cavity in a fixed position and predetermined orientation while the vial is positioned spaced apart from the vial adapter and in axial alignment with the vial adapter. In this intermediate position the piercing mandrel 57 is yet spaced apart to the outer surface of the vial stopper and does not pierce it. From this intermediate position the transfer position, in which the vial adapter is locked onto the front end of the vial, may be established by a relative displacement of the vial and vial adapter in axial direction. More specifically, in the preferred embodiments of the present invention the vial adapter is not moved whereas the vial is pushed in axial direction towards the vial adapter until the vial adapter is locked on the front end of the vial and piercing mandrel has pierced the vial stopper for liquid transfer. In the first embodiment shown in FIG. 3a, the intermediate position of both the vial adapter and vial is identical with the storage position of both the vial adapter and vial.
[0093] For coupling the vial adapter 4 with the vial 7, firstly the packaging foil 8 needs to be removed from the tray 1. FIG. 4a is a cross-sectional view of the tray 1 with the vial adapter 4 and the vial 7 in the intermediate position after removal of the packaging foil 8. In the intermediate position, the vial adapter 4 and the vial 7 are kept spaced apart from each other in a fixed positional relationship and in axial alignment, which means that the center line of the vial adapter 4 will coincide with the center line of the vial 7.
[0094] For initializing the coupling of the vial adapter 4 with the vial 7, the vial 7 is pushed in axial direction towards the vial adapter 4, as shown in FIGS. 3b and 4b. For this purpose, a user's finger or a member of a robot may push the bottom 71 of the vial 7 in the direction of the vial adapter 4. To ease access to the bottom 71 of the vial 7 to a user or robot, the rear end cavity 14 may be provided that may be relatively deep and extend even a little beyond the bottom 17 of the vial cavity 11. When the vial 7 is pushed toward the vial adapter 4, the vial body 70 pushes down the front movement limiting protrusion 35b. As shown in FIG. 5e, during this axial movement of the vial 7 towards the vial adapter 4, the axial alignment of the center axis CL of the vial 7 with the center axis CL of the vial adapter 4 is maintained because the retaining protrusions 36a, 36b of the vial cavity 11 continue pushing down the vial body 70 towards the bottom 17 of the vial cavity 11 and because the retaining protrusions 37a, 37b of the vial adapter cavity 12 (see FIG. 3a) push down the vial adapter towards the bottom of the vial adapter cavity. The metal cap 77 of the vial 7 thus enters the region of the intermediate cavity 13. Finally, the vial 7 reaches the position shown in FIG. 4b, in which the piercing mandrel 57 is about to come in contact with the upper surface of the stopper 76 to start piercing the stopper 76. In this position, the axial alignment of the vial 7 with the vial adapter 4 is maintained at least by the front vial retaining protrusion 36b and preferably also by the rear vial retaining protrusion 36a.
[0095] The piercing mandrel 57 of the vial adapter 4 will thus start piercing the stopper 76 of the vial at its center. When the vial adapter 7 is pushed further toward the vial adapter 4, the bottom bevels of the protrusions 63 of the resilient legs 61 will finally slide along the outer edge of the metal cap 77 of the vial 7 and thus start spreading the resilient legs 61 apart. At the same time, the piercing mandrel 57 will start piercing or puncturing the elastomeric stopper 76 of the vial 7. The piercing mandrel 57 thus assists in maintaining the axial alignment between the vial 7 and vial adapter 4, so that the rear vial retaining protrusions 36a may finally get out of contact with the outer surface of the vial body 70. When the vial 7 is pushed further toward the vial adapter 4, finally the locking protrusions 63 of the vial adapter will grip behind the bottom edge of the metal cap 77 of the vial 7 and the piercing mandrel 57 will have fully penetrated or punctured the vial stopper 76, thus enabling a liquid transfer into and/or out of the vial 7 in the transfer position shown in FIG. 4c.
[0096] In the transfer position of FIG. 4c the assembly consisting of the vial adapter 4 locked onto the front end of the vial 7 can be removed from the tray 1, as shown in FIG. 3d. Gripping of the assembly is eased by the first lateral cavity 15, because the outer surface of the vial body 70 is exposed in this first lateral cavity 15 in the transfer position and may be easily gripped by the fingers of a user or by manipulating members of a robot, such as grippers. FIG. 3d shows the assembly after removal from the tray 1.
[0097] As can be concluded from FIG. 3a, the first lateral cavity 15 may also serve for enabling access to the front end of the vial body 70 by means of the forefinger and middle finger of a user or by means of grippers of a robot, so that the vial body 70 can be gripped and clamped to thus drive the axial displacement of the vial 7 towards the vial adapter 4 from the intermediate position shown in FIG. 3a to the transfer position shown in FIG. 3c. This axial displacement by additionally be driven by a user's thumb contacting the bottom 71 of the vial 7 via the rear cavity 14.
[0098] As the vial adapter 4 and the vial 7 may be stored in the sterile packaging unit under sterile conditions, the assembly is ready for use after removal from the tray 1, and, if required, only the front end of the vial adapter 4 needs to be disinfected again, e.g. by means of a disinfecting swab, before coupling the vial adapter 4 with a medical device, such as a syringe by means of the thread 43. The transfer position may be obtained quickly and reliably, because the tray 1 enables an intuitive operation and because the axial alignment between the vial adapter 4 and vial 7 can be maintained reliably during all stages of operation.
[0099] The above description has assumed the preferred case that the vial adapter 4 rests stationary in the vial adapter cavity 12, while its orientation is maintained by means of the vial adapter retaining protrusions 37a, 37b, as outlined above. However, as will become apparent to the skilled person when studying the above description, the transfer position may also be reached starting with the intermediate position by any other suitable relative motion between the vial adapter 4 and vial 7, including the extreme reverse case that the vial 7 is kept stationary in the vial cavity while the vial adapter 4 is pushed toward the stationary vial 7 and including ‘mixed cases’ where both the vial 7 and the vial adapter 4 are moved in axial direction towards each other. During the axial displacement from the intermediate position to the final transfer position, preferably both the vial adapter and the vial do not move in a direction perpendicular to the axial direction.
[0100] FIGS. 6a-6c show a tray according to a second embodiment of the present invention. Different to the aforementioned first embodiment, the front movement limiting protrusions 35b are formed on side-surfaces of the vial cavity 11 at its front end. The upper side-surfaces of all cavities of the tray 1 may be slanted outward by a small acute angle to enable stacking of a plurality of such trays 1 after use to ease the transport of such trays back to a manufacturer or supplier of vials in a stapled, more compact configuration. When a plurality of such trays 1 are stapled one above the other, the protrusions 37a, 37b, 36a, 36b, 35a automatically serve for maintaining a certain gap between the trays 1 to ease separation of the trays 1. As shown in FIG. 6a, additional spacers 38, formed as protrusions, may be provided on the upper side-surfaces of one or several cavities of the tray 1, to maintain the gaps between the trays in a stapled configuration.
[0101] FIG. 7a shows a sterile packaging unit 9 with a tray 1 according to a third embodiment of the present invention in a position used for long-time storage of the vial and vial adapter. Also in the third embodiment, the storage position corresponds to the intermediate position. In the third embodiment, the vial adapter cavity 12 is sealed by means of a second packaging foil against the remainder of the tray 1, preferably in a sterile manner. The whole tray is sealed against the environment, preferably in a sterile manner, by means of a packaging foil 8 that is bonded on the upper surface of the tray 1. Different to the previous embodiments, the front end 32 of the first lateral cavity 15 is slanted under an acute angle, which is e.g. in the range of about 20 degrees, relative to a normal on the upper surface of the tray 1. A U-shaped passage 33 is formed in the intermediate cavity 13, which is configured so that the front end of the vial including the metal cap 77 may be pushed through and which is sealed against the remainder of the tray 1 by means of the second packaging foil 8a.
[0102] For establishing the transfer position, first the packaging foil 8 needs to be removed, as shown in FIG. 7b, so that the vial 7 and in particular the upper surface of the vial stopper is exposed and may be disinfected, if necessary, by means of a disinfecting swab, before coupling the vial adapter to the vial.
[0103] FIG. 7c shows the front end of the tray 1 with the vial adapter cavity 12 on a larger scale. The second packaging foil 8a is adhesively bonded along the bonding line 8c to the upper surface of the tray 1 and the slanted front end 32 of the first lateral cavity 15. The bonding line 8c extends the entire perimeter of the vial adapter cavity 12, so that the vial adapter cavity 12 can be sterile sealed, if required. To ease peeling-off the second packaging foil 8a, a corner portion 8b of the second packaging foil 8a is not bonded on the upper surface of the tray 1.
[0104] After peeling-off the second packaging foil 8a, both the vial adapter 4 and the vial 7 are partially exposed in the intermediate position shown in FIG. 7d, and for establishing the transfer position and locking the vial adapter 4 onto the front end of the vial 7, the vial 7 only needs to be displaced in axial direction, guided at least by the front vial retaining protrusions 36b of the vial cavity 11, as outlined above. Finally, the assembly consisting of the vial adapter 4 locked onto the front end of the vial 7 can be removed from the tray, as outlined above.
[0105] FIG. 8a shows a sterile packaging unit 9 with a tray 1 according to a fourth embodiment of the present invention in a position used for long-time storage of the vial 7 and vial adapter 4.
[0106] Different to the previous embodiments, the storage position of the vial adapter 4 is different to the intermediate position. As shown in FIG. 8a, the tray 1 includes a vial adapter tray member 100 that includes a vial adapter storage cavity 101 used for long-time storage of the vial adapter 4. In this embodiment the vial adapter tray member 100 is connected with the tray 1 via a hinge 102. Preferably, the vial adapter tray member 100 and the tray 1 are integral, and the hinge 102 may be a film hinge formed integral with the vial adapter tray member 100 and tray 1. In the storage position, the whole packaging unit 9 may be sealed against the environment, preferably under sterile conditions, by means of a packaging foil 8 bonded on the upper surfaces of the vial adapter tray member 100 and tray 1.
[0107] After removal of the packaging foil 8, at least the vial 7 in the vial cavity 11 may be exposed partially, as shown in FIG. 8b. Preferably, in the fourth embodiment the vial adapter storage cavity 101 is separately sealed against the remainder of the tray by means of a second packaging foil 8a, preferably under sterile conditions. As shown in FIG. 8b, the second packaging foil 8a may be bonded on the upper surface of the vial adapter tray member 100.
[0108] After peeling-off the second packaging foil 8a, both the vial adapter 4 and the vial 7 are partially exposed in the position shown in FIG. 8c. In order to transfer the vial adapter 4 into the vial adapter cavity 12 of the tray 12, the vial adapter tray member 100 is pivoted about the hinge 102 until the upper surfaces of the vial adapter tray member 100 and tray 1 are flush with each other and the vial adapter storage cavity 101 is positioned vertical above the vial adapter cavity 12, as shown in FIG. 8d. As the vial adapter 4 is not locked in the vial adapter storage cavity 101 it will fall downward into the vial adapter cavity 12 of the tray 1, as shown in FIG. 8e. Then, the vial adapter tray member 100 can be pivoted backward about the hinge 102 to reach the position shown in FIG. 8f. In this position it might be necessary to push the vial adapter 4 fully into the vial adapter cavity 12, e.g. by means of the finger of a user or a member of a robot, to overcome the small resistance force provided by the vial adapter retaining protrusions 37a, 37b of the vial adapter cavity 12. Finally, the intermediate position will be established, in which the vial adapter 4 is positioned inside the vial adapter cavity 12 in a fixed position and predetermined orientation, retained in the vial adapter cavity 12 by the vial adapter retaining protrusions 37a and 37b, while the vial 7 is positioned spaced apart from the vial adapter 4 and in axial alignment with the vial adapter 4, as shown in FIG. 8f. For the transfer of the vial adapter 4 from the intermediate position to the transfer position, the vial 7 simply needs to be displaced in axial direction towards the vial adapter 4, as outlined above.
[0109] FIG. 9 shows a modification of the packaging unit of FIG. 8a. Different to the packaging unit of FIG. 8a, in the packaging unit 9 of this embodiment only the vial adapter storage cavity 101 is sealed against the environment by a packaging foil 8a that is bonded on the upper surface of the vial adapter tray member 100 only, preferably under sterile conditions. The packaging unit 9 of this embodiment can be delivered to customers in the position shown in FIG. 9, or as an alternative without the vial 7. To establish the transfer position, then first the vial 7 needs to be inserted into the vial cavity 11 and locked therein by means of the vial retaining protrusions 36a and 36b. If necessary, the upper surface of the vial stopper, which is exposed in the position shown in FIG. 9, may be disinfected, e.g. by means of a disinfecting swab, before coupling the vial adapter to the vial. The position shown in FIG. 9 corresponds to that shown in FIG. 8b and explained above. In this position, the vial adapter 4 is stored in a storage position in the vial adapter storage cavity 101, whereas the vial 7 is accommodated in the vial cavity 11 already in its intermediate position. To establish the transfer position and couple the vial adapter and the vial, the sequence of methods steps outlined above with reference to FIGS. 8c-8f needs to be performed.
[0110] FIGS. 10a and 10b show a packaging unit with a tray according to a further embodiment of the present invention. Here, a tray member insert 100 is provided as a separate member that can be inserted into a cavity 12a of the tray 1. According to this embodiment, the vial adapter 4 is stored in the cavity 12 of the insert 100 and sealed against the environment by a packaging foil 8a, preferably in a sterile manner. More specifically, the packaging foil 8a is bonded on the upper surface of the insert 100 and the slanted front wall 32. When the insert 100 is fully inserted into the cavity 12a of the tray 1, the vial adapter will be automatically disposed in the intermediate position outlined above, in which the vial adapter 4 is positioned inside the vial adapter cavity 12 of the insert 100 in a fixed position and predetermined orientation, retained by vial adapter retaining protrusions, while the vial 7 is positioned spaced apart from the vial adapter 4 and in axial alignment with the vial adapter 4. To establish the transfer position and couple the vial adapter 4 and the vial 7, the vial 7 simply needs to be pushed in axial directions towards the vial adapter 4 as outlined above. If necessary, the upper surface of the vial stopper, which is exposed in the position shown in FIG. 10b, may be disinfected, e.g. by means of a disinfecting swab, before coupling the vial adapter 4 to the vial 7. According to this embodiment, the vial adapter 4 may be supplied by a manufacturer as a separate component, already packaged in the specifically designed insert 100. Or, the vial adapter 4 may be supplied also by the manufacturer of the vials already packaged in the specifically designed insert 100. The tray 1 may be stored or reused at the side of the customer, and the customer may insert the vial 7 into vial cavity 11 of the tray 1 on his own. Or, the tray 1 together with the vial 7 retained in the vial cavity 11 may be supplied by the manufacturer of the vial to the customer.
[0111] As will become apparent to the skilled person when studying the above description, a tray according to the present invention may be used for the storage/positioning of any kind of transfer adapter enabling a liquid transfer into and/or out of a medical container and for the storage/positioning of any other kind of medical container except vials, such as cartridges or syringe bodies.
[0112] Of course, a vial adapter as outlined above may also be coupled with additional units for liquid transfer when positioned/stored in a tray according to the present invention. As an example for such a combination of a vial adapter with an additional unit, FIG. 1c shows a vial adapter 4, which is coupled with a pump dispenser 5. Such a combined vial adapter unit may be positioned/stored in the same manner, as outlined above for the vial adapter itself, in a tray according to the present invention. As shown in FIG. 1c, the vial adapter comprises a coupling portion 65a configured for coupling with the additional unit, namely in this case with the pump dispenser 5. The coupling portion 65a may be a cylindrical portion with a thread on its outer surface for screwing on the pump dispenser 5. At its front end, the vial adapter 4 of FIG. 1c further comprises a finger rest 65b so that the vial adapter 4 together with the pump dispenser 5 may be grasped easily. The pump dispenser 5 comprises a pump dispenser main body 65c, which may include a standard pumping mechanism, and a pump dispenser spray unit 65d, which may at the same time serve as an operating button for operating the pumping mechanism by pushing down the pump dispenser spray unit 65d repeatedly.
[0113] While the preferred embodiments of the present invention have been described so as to enable one skilled in the art to practice the device of the present invention, it is to be understood that variations and modifications may be employed without departing from the concept and intent of the present invention as defined in the appended claims. Accordingly, the preceding description is intended to be exemplary and should not be used to limit the scope of the invention. The scope of the invention should be determined only by reference to the appended claims.
LIST OF REFERENCE NUMERALS
[0114] 1 tray [0115] 4 vial adapter [0116] 5 pump dispenser [0117] 7 vial [0118] 8 foil [0119] 8a second foil [0120] 8b unbonded corner of second foil 8a [0121] 8c bonding line [0122] 9 combined packaging unit [0123] 10 tray member [0124] 10a upper surface of tray member 10 [0125] 11 vial cavity [0126] 12 vial adapter cavity [0127] 12a cavity for accommodating tray member insert 100 [0128] 12b slanted partition [0129] 12c bottom [0130] 13 intermediate cavity [0131] 14 rear end cavity [0132] 15 first lateral cavity [0133] 16 second lateral cavity [0134] 17 bottom of vial cavity 16 [0135] 17a upper side-wall of vial cavity 16 [0136] 18 first cavity [0137] 18a bottom of first cavity 18 [0138] 18b upper side-wall of first cavity 18 [0139] 19 front wall [0140] 20 first stop surface [0141] 21 second cavity [0142] 22 bottom of second cavity 21 [0143] 22a upper side-wall of second cavity 21 [0144] 23 second stop surface [0145] 24 third cavity [0146] 25 bottom of third cavity 24 [0147] 25a upper side-wall of third cavity 24 [0148] 26 side-wall of second lateral cavity 16 [0149] 27 side-wall of intermediate cavity 13 [0150] 28 bottom of intermediate cavity 13 [0151] 29 side-wall of first lateral cavity 15 [0152] 30 side-wall of rear end cavity 14 [0153] 31 rear wall [0154] 32 slanted partition [0155] 33 passage [0156] 35a rear movement limiting protrusion [0157] 35b front movement limiting protrusion [0158] 35c front movement limiting protrusion [0159] 36a rear vial retaining protrusion [0160] 36b front vial retaining protrusion [0161] 37a rear vial adapter retaining protrusion [0162] 37b front vial adapter retaining protrusion [0163] 38 spacer [0164] 40 valve body [0165] 41 connecting ring [0166] 42 coupling body [0167] 43 thread [0168] 44 front opening [0169] 45 valve member [0170] 46 valve stem [0171] 47 central channel [0172] 48 first cylindrical portion [0173] 49 conical portion [0174] 50 second cylindrical portion [0175] 51 first step [0176] 52 connection region [0177] 53 cylindrical wall [0178] 54 second step [0179] 55 top wall [0180] 56 third step [0181] 57 piercing mandrel [0182] 58 cannula [0183] 58a mouth of cannula 58 [0184] 59 transfer channel [0185] 60 skirt [0186] 61 resilient leg [0187] 62 slot [0188] 63 locking protrusion [0189] 64 bottom end [0190] 65a coupling portion [0191] 65b finger rest [0192] 65c pump dispenser main body [0193] 65d pump dispenser spray unit [0194] 70 vial body [0195] 71 vial bottom [0196] 72 bottom edge [0197] 73 shoulder [0198] 74 neck [0199] 75 rolled edge of vial [0200] 76 rubber stopper [0201] 77 metal cap [0202] 78 central hole [0203] 80 contact region [0204] 100 vial adapter tray member/tray member insert [0205] 101 vial adapter storage cavity [0206] 102 hinge [0207] 103 locking protrusion [0208] 104 supporting leg [0209] CL center line [0210] h1 height of center line CL over bottom of vial cavity 11 [0211] h2 height of contact region 80 over bottom of vial cavity 11
