Heparin sodium supported hydrogel sustained-release paster

Abstract

The present invention relates to a medical dressing, in particular to a heparin sodium supported hydrogel sustained-release paster. The inventive heparin sodium supported hydrogel sustained-release paster includes a fixing layer and a backing layer and a hydrogel functional layer successively arranged on the fixing layer. The hydrogel functional layer is made up of hydrophilic high-molecular compound, heparin sodium and aqueous transdermal absorbefacient solution to through high-energy ray radiation or freeze-thaw cycle or combination of high-energy ray radiation and freeze-thaw cycle. The invention has the advantages as follows: the flake solid hydrogel material, synthesized by hydrophilic high-molecular compound with high biosecurity, has features of high biosecurity, high moisture content, compact molecular structure, controllable is water loss rate and prolonged service life. In addition, the hydrogel sustained-release paster is easy in operation, convenient to use, timely to remove in case of discomfortable and adverse reaction and free of deteriorated adverse reaction.

Claims

1. A hydrogel sustained-release paster supporting heparin sodium, comprising a fixing layer, a backing layer and a hydrogel functional layer; wherein the backing layer and the hydrogel functional layer are successively arranged on the fixing layer; the hydrogel functional layer is made of an aqueous solution comprising a hydrophilic compound, the heparin sodium and an aqueous transdermal absorbefacient through high-energy ray radiation or freeze-thaw cycle or combination of high-energy ray radiation and freeze-thaw cycle.

2. The hydrogel sustained-release paster supporting the heparin sodium according to claim 1, wherein the aqueous solution of the hydrogel functional layer comprises the 5%-45% hydrophilic compound by mass, the 0.07%-5% heparin sodium by mass and the 1-5% aqueous transdermal absorbefacient by mass.

3. The hydrogel sustained-release paster supporting the heparin sodium according to claim 2, wherein the hydrophilic compound is one or more selected from the group consisting of starch, water-soluble cellulose, water-soluble chitosan, agar, carrageenin, arabic gum, pectin, xanthan gum, carrageenan, alginate, hyaluronic acid, gelatin, bone glue, polyglutamic acid, polylysine, fibrous protein, elastin, keratin, polyacrylamide, polyacrylic acid, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyvinyl alcohol, polymaleic anhydride, polyquarternium, polyethylene glycol, polyethylene oxide and polyvinylpyrrolidone in any proportion.

4. The hydrogel sustained-release paster supporting the heparin sodium according to claim 2, wherein the heparin sodium is a bovine-derived heparin sodium or a pig-derived low-molecular heparin sodium, wherein a content of the heparin sodium with a molecular weight of less than 16000 is more than 65%.

5. The hydrogel sustained-release paster supporting the heparin sodium according to claim 2, wherein the transdermal absorbefacient is a laurocapram.

6. The hydrogel sustained-release paster supporting the heparin sodium according to claim 1, wherein the backing layer is a semipermeable membrane or a nonwoven cloth with a water vapor permeability of 500-800 g/(m.sup.2.Math.24 h).

7. The hydrogel sustained-release paster supporting the heparin sodium according to claim 1, wherein the fixing layer is a medical adhesive tape.

8. The hydrogel sustained-release paster supporting the heparin sodium according to claim 2, wherein the backing layer is a semipermeable membrane or a nonwoven cloth with a water vapor permeability of 500-800 g/(m.sup.2.Math.24 h).

9. The hydrogel sustained-release paster supporting the heparin sodium according to claim 3, wherein the backing layer is a semipermeable membrane or a nonwoven cloth with a water vapor permeability of 500-800 g/(m.sup.2.Math.24 h).

10. The hydrogel sustained-release paster supporting the heparin sodium according to claim 4, wherein the backing layer is a semipermeable membrane or a nonwoven cloth with a water vapor permeability of 500-800 g/(m.sup.2.Math.24 h).

11. The hydrogel sustained-release paster supporting the heparin sodium according to claim 5, wherein the backing layer is a semipermeable membrane or a nonwoven cloth with a water vapor permeability of 500-800 g/(m.sup.2.Math.24 h).

12. The hydrogel sustained-release paster supporting the heparin sodium according to claim 2, wherein the fixing layer is a medical adhesive tape.

13. The hydrogel sustained-release paster supporting the heparin sodium according to claim 3, wherein the fixing layer is a medical adhesive tape.

14. The hydrogel sustained-release paster supporting the heparin sodium according to claim 4, wherein the fixing layer is a medical adhesive tape.

15. The hydrogel sustained-release paster supporting the heparin sodium according to claim 5, wherein the fixing layer is a medical adhesive tape.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0018] FIGURE is a structural diagram of the inventive hydrogel sustained-release paster supporting heparin sodium.

[0019] In the FIGURE, the parts represented by the labels are listed below:

[0020] 1. fixing layer, 2. backing layer, 3. hydrogel functional layer.

DETAILED DESCRIPTION OF THE EMBODIMENTS

[0021] Next, the inventive principle and features are described with reference to the accompanying FIGURES, and all examples are only used to explain the present invention, not to limit the scope of the present invention.

Embodiment 1

[0022] as shown in the FIGURE, the hydrogel sustained-release paster supporting heparin sodium of the embodiment comprises a fixing layer 1 and a backing layer 2 and a hydrogel functional layer 3 successively arranged on the fixing layer 1, wherein the hydrogel functional layer is made by fully dissolving 10% of polyvinyl alcohol, 0.07% of heparin sodium, 1% of laurocapram and 88.93% of water in weight percent and then freeze-thaw cyclic synthesis; the backing layer is semipermeable membrane with water vapor permeability of 500 g/(m.sup.2.Math.24 h), and the backing layer 2 is tightly bonded with the hydrogel functional layer 3; the fixing layer 1 is of a medical adhesive tape bonded with the backing layer 2 tightly.

[0023] About 12 hours after applying the hydrogel sustained-release paster on abdominal area, the result, detected by heparin sodium content in hydrogel functional layer 3 and four coagulation tests, shows 44% of human's absorbing capacity to heparin sodium and human's coagulation four indices similar to low-molecular-weight heparin sodium absorbed by human body.

Embodiment 2

[0024] the hydrogel sustained-release paster supporting heparin sodium of the embodiment comprises a fixing layer 1 and a backing layer 2 and a hydrogel functional layer 3 successively arranged on the fixing layer 1, wherein the hydrogel functional layer is made by fully dissolving 10% of polyvinyl alcohol, 2% of polyvinylpyrrolidone, 1% of heparin sodium, 5% of laurocapram and 82% of water in weight percent and then high-energy electron beam radiation synthesis; the backing layer is nonwoven cloth with water vapor permeability of 800 g/(m.sup.2.Math.24 h), and the backing layer 2 is tightly bonded with the hydrogel functional layer 3; the fixing layer 1 is of a medical adhesive tape, separated from the sustained-release paster, by which the hydrogel sustained-release paster is fixed on wounded parts during use.

[0025] About 24 hours after applying the hydrogel sustained-release paster on abdominal area, the result, detected by heparin sodium content in hydrogel functional layer 3 and four coagulation tests, shows 60% of human's absorbing capacity to heparin sodium and human's coagulation four indices similar to low-molecular-weight heparin sodium absorbed by human body.

Embodiment 3

[0026] the hydrogel sustained-release paster supporting heparin sodium of the embodiment comprises a fixing layer 1 and a backing layer 2 and a hydrogel functional layer 3 successively arranged on the fixing layer 1, wherein the hydrogel functional layer is made by fully dissolving 20% of polyacrylic acid, 25% of starch, 3% of heparin sodium, 2% of laurocapram and 50% of water in weight percent and then gamma radiation synthesis; the backing layer is nonwoven cloth with water vapor permeability of 650 g/(m.sup.2.Math.24 h), and the backing layer 2 is tightly bonded with the hydrogel functional layer 3; the fixing layer 1 is of a medical adhesive tape bonded with the backing layer 2 tightly.

[0027] About 24 hours after applying the hydrogel sustained-release paster on abdominal area, the result, detected by heparin sodium content in hydrogel functional layer 3 and four coagulation tests, shows 66% of human's absorbing capacity to heparin sodium and human's coagulation four indices similar to low-molecular-weight heparin sodium absorbed by human body.

Embodiment 4

[0028] the hydrogel sustained-release paster supporting heparin sodium of the embodiment comprises a fixing layer 1 and a backing layer 2 and a hydrogel functional layer 3 successively arranged on the fixing layer 1, wherein the hydrogel functional layer is made by fully dissolving 10% of polyvinyl alcohol, 2% of polyvinylpyrrolidone, 1% of xanthan gum, 0.5% of heparin sodium, 2.5% of laurocapram and 84% of water in weight percent and then combination of freeze-thaw cyclic synthesis and high-energy electron beam radiation synthesis; the backing layer is semipermeable membrane with water vapor permeability of 700 g/(m.sup.2.Math.24 h), and the backing layer 2 is tightly bonded with the hydrogel functional layer 3; the fixing layer 1 is of a medical adhesive tape bonded with the backing layer 2 tightly.

[0029] About 24 hours after applying the hydrogel sustained-release paster on human calves, the result, detected by heparin sodium content in hydrogel functional layer 3 and four coagulation tests, shows 29% of human's absorbing capacity to heparin sodium and human's coagulation four indices similar to low-molecular-weight heparin sodium absorbed by human body.

[0030] Embodiment 5: the hydrogel sustained-release paster supporting heparin sodium of the embodiment comprises a fixing layer 1 and a backing layer 2 and a hydrogel functional layer 3 successively arranged on the fixing layer 1, wherein the hydrogel functional layer is made by fully dissolving 2% of sodium polyacrylate, 5% of polyethylene glycol, 5% of polyving alcohol, 1% of heparin sodium, 1% of laurocapram and 86% of water in weight percent and then freeze-thaw cyclic synthesis; the backing layer is nonwoven cloth with water vapor permeability of 700 g/(m.sup.2.Math.24 h), and the backing layer 2 is tightly bonded with the hydrogel functional layer 3; the fixing layer 1 is of a medical adhesive tape bonded with the backing layer 2 tightly.

[0031] About 24 hours after applying the hydrogel sustained-release paster on abdominal area, the result, detected by heparin sodium content in hydrogel functional layer 3 and four coagulation tests, shows 50% of human's absorbing capacity to heparin sodium and human's coagulation four indices similar to low-molecular-weight heparin sodium absorbed by human body.

[0032] In above-mentioned five embodiments, the backing layer 2 is connected with the fixing layer 1 by a bonding mode, or a fixed or a detachable mode for convenient use and storage.

[0033] The above statements are just preferred embodiments of the present invention rather than limitation. Any modification, equal to replacement and improvement within the spirit and principle of the invention, should be included in protective range of the invention.