Use of american ginseng to counteract cannabis-induced intoxication

Abstract

A composition and method for the use of Panax quinquefolius for the attenuation of Cannabis-induced dysphoria where dosage can be effectively administered in a gum base cold pressed into a tablet containing at least 300 mg of Panax quinquefolius and Maltitol, Sorbitol, Isomalt, Xylitol, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.

Claims

1. A method to reverse the intoxication in a human intoxicated by cannabis use consisting essentially of administering to said human a therapeutically effective amount of a composition of Panax quinquefolius where the amount of Panax quinquefolius is at least 300 mg in the composition and the composition is a chewing gum.

Description

DETAILED DESCRIPTION OF THE INVENTION

(1) The present invention described herein is the use of Panax quinquefolius (aka American Ginseng), including any processed (e.g. extracts, conjugates, heated, cooked, etc.) or unprocessed form of the plant, including roots, leaves and seeds, for the attenuation of Cannabis-induced dysphoria incorporated within a gum base with the below included ingredients for efficacious delivery to the user through the ordinary process of gum chewing. The gum base is formulated utilizing a cold pressed manufacturing process to incorporate all of the ingredients with heightened efficacy into a circular half inch diameter tablet. The ingredients incorporated into the gumbase are, Maltitol, Sorbitol, Isomalt, Xylitol, American Ginseng (African Panax quinquefolius) 300 mg per piece, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.

(2) Panax quinquefolius is a herbaceous perennial plant in the ivy family, commonly used as herbal medicine. American ginseng was formerly particularly widespread in the forested regions of the Eastern United States, Appalachian and Ozark regions. However, due to its popularity and destruction of its habitat, the wild plant has been overharvested, and is rare in most parts of the United States and Canada. Currently, most American ginseng is grown commercially and is not wild-harvested. American ginseng is used for a wide variety of ailments in herbal medicine, from improving digestion, to improving immune function, to treating insomnia and anxiety. Approximately 200 substances have been isolated from ginseng including ginsenosides, polyacetylenes, alkaloids, polysaccharides, oligosaccharides, oligopeptides, phenolic compounds, lipids, vitamins, and minerals (Kolodziej et al., Chemical composition and chosen bioactive properties of Panax quinquefolius extracts. Chemija 24(2):151-159, 2013). Nonvolatile ginsenosides and falcarinol, a natural pesticide and fatty alcohol, are believed to be the main pharmacologically-active ginseng constituents (Kolodziej et al., Chemical composition and chosen bioactive properties of Panax quinquefolius extracts. Chemija 24(2):151-159, 2013).

(3) Of special interest to cannabis-induced dysphoria, is the presence of falcarinol in American ginseng. Falcarinol is found at concentrations of up to 14% in the roots of Panax quinquefolius (Kolodziej et al., Chemical composition and chosen bioactive properties of Panax quinquefolius extracts. Chemija 24(2):151-159, 2013). Falcarinol contains special properties with regard to reducing the psychoactive effects of cannabis. Most importantly, falcarinol has been shown to be a potent inverse agonist at the CB1 receptor, and thus would reverse the effects of CB1 agonism, and thereby attenuate cannabis-induced dysphoria (Leonti et al., Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochemical Pharmacology 79(12):1815-1826, 2010). American ginseng, via Falcarinol's CB1 inverse agonist properties, would thereby attenuate cannabis-induced dysphoria.

(4) It is an object of this invention to provide a method for detoxification comprising administering a therapeutically effective amount of a composition containing American Ginseng that reduces the psychotropic activity caused by the consumption of cannabis.