THE CHEMICAL COMPOSITION FOR IMPREGNATION VIA SPRAYING ON DISPOSABLE SUGICAL MASKS, SLEEVES GOWNS MADE FROM HYDROPHILIC AND HYDROPHOBIC MATERIALS FOR THE INACTIVATION OF BACTERIA AND VIRUSES SUCH AS CORONAVIRUS, SARS, MERS, INFLUENZA A AND INFLUENZA B VIRUSES

Abstract

This invention relates to the Chemical Composition for impregnation via spraying on disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials to inactivate bacteria and viruses, comprising of colloidal silver nanoparticles, Isopropanol Alcohol/Ethanol Alcohol Chlorhexidine/Quaternary Ammonium Compound, Peppermint/Spearmint Essential oils and water.

Claims

1) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses comprising of the synergistic chemical formulation.

2) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 1 wherein the synergistic chemical formulation comprising of comprising of aqueous colloidal silver nanoparticles, Isopropanol Alcohol/Ethanol Alcohol, Chlorhexidine gluconate/Quaternary Ammonium Compound, Peppermint/Spearmint Essential oils and water.

3) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 2 wherein aqueous colloidal silver nanoparticles is 5-30% by weight and with size ranges from 2-150 nm.

4) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 2 wherein 50-85% by weight of synergistic chemical is Isopropanol/Ethanol Alcohol.

5) The chemical composition suitable for Impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 2 wherein 0.1%-8% by weight of the synergistic chemical is Chlorhexidine gluconate/quaternary ammonium compound.

6) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 5, wherein, 0.1-8% by weight of the synergistic chemical formula is chlorhexidine gluconate.

7) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 2, wherein, 0.1%-5 by weight of the chemical formula is Peppermint/Spearmint essential oil.

8) The chemical composition suitable for impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 2, wherein 2-17% by weight of the chemical formula is water.

9) The chemical composition suitable impregnation of disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials for inactivation bacteria and enveloped viruses as in claimed 2-8, wherein the said chemical formula increases the residual inactivation efficacy against enveloped viruses and bacteria of the disinfectant via its binding to disulphide or sulfhydryl groups in cell wall proteins where the metabolic processes are disrupted, leading to cell death.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0077] The following descriptions are exemplary embodiments only, and are not intended to limit the scope, applicability or configuration of the invention in any way. Rather, the following description provides a convenient illustration for implementing exemplary embodiments of the invention. Various changes to the described embodiments may be made in the function and arrangement of the elements described without departing from the scope of the invention as set forth in the appended claims.

[0078] According to the aspect of the present invention, it is the object of the invention to provide the Chemical Composition for impregnation via spraying into disposal surgical masks and surgical sleeved gowns to inactivate bacteria and enveloped viruses such as Coronavirus, SARS, MERS, Influenza A and Influenza B. The said chemical composition comprising of aqueous colloidal silver nanoparticles, Isopropanol Alcohol/Ethanol, Chlorhexidine gluconate/Quaternary Ammonium Compound (alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, and dialkyl dimethyl ammonium chloride) and Peppermint/Spearmint Essential oils and water.

[0079] In an embodiment of the said invention, the aqueous colloidal silver nanoparticle is used as co-disinfectant and to enhance the excellent residual effect of antimicrobial properties of the disinfectant impregnated into the disposal surgical mask and sleeved gowns. The aqueous colloidal silver nanoparticle's antimicrobial effect has been demonstrated in numerous applications against different types of microorganisms. The mechanism behind the bactericidal efficacy of the aqueous silver nanoparticles is through its binding to disulphide or sulfhydryl groups in cell wall proteins. Silver nanoparticle also binds to DNA. Through these binding events, metabolic processes are disrupted, leading to cell death. The size of the colloidal silver nanoparticle ranges from 2-150 nm. The optimal size of spherical silver nanoparticles (AgNPs) for off-resonance surface-enhanced Raman scattering (SERS) was found to be ˜50 nm based on the equivalent Ag content in AgNP colloids. Hence, the preferred size of the colloidal size nano-size is 50 nm.

[0080] In another embodiment of said invention Isopropanol/Ethanol is used to increase the hydrophilic properties of the peppermint/spearmint essential oils and to facilitate the ease of said chemical composition to be impregnated into disposal surgical masks and sleeved gowns made from hydrophobic materials. It is also used for the denaturation of the capsid protein of the enveloped viruses such as Coronavirus, SRAS, MERS, Influenza A, Influenza B and for destroying the peptidoglycan/lipopolysaccharide cell wall of the bacteria. The preferred alcohol is Isopropanol Alcohol because it less dehydrating on living tissue and so is a better solution for disinfecting skin than ethanol. It is also effective against bacteria spores.

[0081] In yet another embodiment of the said invention, chlorhexidine gluconate/Quaternary Ammonium Compound (alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, and dialkyl dimethyl ammonium chloride) is used as a co-disinfectant for the said chemical composition. Chlorhexidine gluconate is the preferred choice due to its a broad-spectrum biocide property and its effectiveness against Gram-positive bacteria, Gram-negative bacteria and fungi. It has excellent for both bacteriostatic (inhibits bacterial growth) and bactericidal (kills bacteria) making it an excellent choice for the said chemical composition used for the impregnation disposal surgical masks and sleeved surgical gowns.

[0082] In yet another embodiment of the said invention Peppermint/Spearmint essential oil is used to further enhanced the antimicrobial effect of the said invention. The preferred essential oil is peppermint, when used in a mixture of polar solvent such as Isopropanol Alcohol it is highly effective against Bacillus subtilis, Pseudomonas aeruginosa, Streptococcus aureus than Pseudomonas aureus and Serratia marcescens. Peppermint essential oil is also found to possess antiviral and fungicidal activities.

[0083] In yet another further embodiment, water is primarily used to as as a catalyst and has a major role in denaturing the proteins of cell membranes of viruses and bacteria. Also, the function of water slows down evaporation of said chemical composition and increases the surface contact time with the membrane and as a carrier for the all the above-mentioned ingredients of the said chemical composition. Preferred water is municipal fresh water due to its ease of access.

[0084] The detailed chemical composition for Impregnation via spraying on disposal surgical masks and sleeved Gowns made from Hydrophilic and Hydrophobic materials for inactivation bacteria and enveloped viruses such as Coronavirus, SARS, MERS, Influenza A and Influenza B is herein described:

[0085] 1) In accordance with the invention, the main constituent of the chemical composition comprising 50-85% by weight of Isopropanol/Ethanol Alcohol, 0.1-8% by weight Chlorhexidine gluconate/Quaternary Ammonium Compound (alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, and dialkyl dimethyl ammonium chloride) 5-30% by weight of aqueous colloidal silver nanoparticles 0.1-5% by weight of Peppermint/Spearmint essential oils and 2-17% by weight of water.

[0086] 2) 50-85% by weight of Isopropanol Alcohol/Ethanol Alcohol is loaded to the mixing mixer tank to be mixed for 10-15 minutes with 2-17% by weight of water.

[0087] 3) 0.1-8% by weight Chlorhexidine gluconate/Quaternary Ammonium Compound (alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, and dialkyl dimethyl ammonium chloride) is then added in the above mixture in the mixing mixer tanks for 5-10 minutes.

[0088] 4) 5-30% of colloidal silver nanoparticle is then added into said tank and mixed for 10-15 minutes.

[0089] 5)) 0.1-5% by weight of peppermint/spearmint essential oil is then added into said tank and mixed for 15-20 minutes.

[0090] 6) 2-17% by weight of water is then added into the said tank to be mixed for about 10 minutes and then chemical composition is ready to be used for impregnation of disposable surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials.

EXAMPLES

[0091] The following are the illustrative of various embodiments of the foregoing invention.

Example 1

[0092] This example illustrates the chemical composition comprising of aqueous colloidal silver nanoparticles, Isopropanol Alcohol/Ethanol Alcohol, Chlorhexidine glucoante/Quaternary Ammonium Compound (alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, and dialkyl dimethyl ammonium chloride), Peppermint/Spearmint Essential Oils and water used for impregnating disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials which typically consists of 20% by weight of aqueous colloidal silver nanoparticles, 70% by weight of Isopropanol Alcohol, 0.4 % by weight of Chlorhexidine gluconate 1% by weight of Peppermint oil and 8.6% by weight of water.

Example 2

[0093] This example illustrates the chemical composition comprising of colloidal silver nanoparticle, Isopropanol/Ethanol Alcohol, Chlorhexidine/Quaternary Ammonium Compound, Peppermint/Spearmint Essential Oils and water used for impregnating disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials which typically consists 12% by weight of aqueous colloidal silver nanoparticles, 71% by weight of Isopropanol Alcohol, 1% by weight of Chlorhexidine gluconate, 1% by weight of Peppermint oil and 15% by weight of water.

Example 3

[0094] This example illustrates the chemical composition comprising of colloidal silver nanoparticle, Isopropanol/Ethanol Alcohol, Chlorhexidine gluconate/Quaternary Ammonium Compound (alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, and dialkyl dimethyl ammonium chloride), Peppermint/Spearmint Essential Oils and water used for impregnating disposal surgical masks and sleeved gowns made from hydrophilic and hydrophobic materials which typically consists of 10% by weight of aqueous colloidal silver nanoparticles, 70% by weight of Isopropanol Alcohol, 2% by weight of Chlorhexidine 1% by weight of Peppermint essential oil and 17% by weight of water.