AFTER-INSECT BITE DEVICE AND METHOD
20190175392 ยท 2019-06-13
Assignee
Inventors
- Giacomo Cossolini (Bergamo, IT)
- Fabio Balzarini (Bergamo, IT)
- Silvia Carpino (Bergamo, IT)
- Umberto Trotta (Ponte San Pietro, IT)
- Roberto Balzarini (Stezzano, IT)
Cpc classification
A61K36/28
HUMAN NECESSITIES
A61F7/02
HUMAN NECESSITIES
A61K36/53
HUMAN NECESSITIES
A61F2007/0071
HUMAN NECESSITIES
International classification
A61F7/02
HUMAN NECESSITIES
A61K36/53
HUMAN NECESSITIES
A61K36/28
HUMAN NECESSITIES
A61F7/00
HUMAN NECESSITIES
Abstract
They are described an after-insect bite device (100) and method. The device (100) comprises a container body (10); an applicator head (30) extending from one end (14) of the container body (10); and a reservoir (50) housed within the container body (10) and adapted to contain a mixture (M) that is intended to be applied, through said applicator head (30), onto a part affected by the insect bite. The mixture (M) is a mixture (M) of completely vegetal substances and the device (100) further comprises heating means (40) housed within the container body (10) and which can be activated by switching on/off means (70) of said device (100) to heat said part affected by the insect bite, before applying said mixture (M).
Claims
1. After-insect bite device comprising: a container body; an applicator head extending from one end of said container body; a reservoir housed within the container body and adapted to contain a mixture (M) that is intended to be applied, through said applicator head, onto a part affected by the insect bite; characterized in that said mixture (M) is a mixture (M) of completely vegetal substances and in that the device further comprises heating means housed within the container body and which can be activated by switching on/off means of said device to heat said part affected by the insect bite, before applying said mixture (M).
2. Device according to claim 1, further comprising a control unit housed within said container body and configured to heat the heating means to a denaturation temperature (Tden) varying from about 60 C. to about 90 C.
3. Device according to claim 2, wherein said control unit comprises a timer configured to maintain said denaturation temperature (Tden) for a predetermined time (t) varying from 3 and 5 seconds.
4. Device according to claim 3, wherein said predetermined time (t) is of 5 seconds.
5. Device according to claim 1, further comprising power supply means of said heating means, which are housed within said container body and comprise a battery.
6. Device according to claim 1, wherein said reservoir comprises a valve for dispensing a predetermined amount of said mixture (M) onto the part affected by the insect bite, after heating said part.
7. Device according to claim 6, wherein said predetermined amount of said mixture (M) which is dispensed onto the part affected by the insect bite is from about 0.02 to about 0.05 ml.
8. Device according to claim 6, wherein said dispensing valve is activated by said switching on/off means.
9. Device according to claim 2, further comprising an insulating element, which is housed within the container body between said control unit and said heating means and is adapted to thermally insulate said control unit and said heating means therebetween.
10. Device according to claim 1, wherein said heating means consist of an electric resistance inserted in a longitudinal hole formed in said applicator head.
11. Device according to claim 1, further comprising a closing plug of one end of said container body which is opposite to the end from which said applicator head extends.
12. Device according to claim 1, wherein said mixture (M) consists of essential oils dispersed in an inert solvent.
13. Device according to claim 12, wherein said essential oils can be selected from: Mimosa extract, Calendula extract, Althea extract, Alcanna extract, Bugleweed extract, Goji berry extract, Blackcurrant extract, Plantago Lanceolata extract, Jujube extract, Lavender essential oil, Blumea essential oil, and combinations thereof.
14. Device according to claim 1, wherein said mixture (M) further includes other components that can be selected from: menthyl lactate, rennet, milk whey, vitamin D, vitamin E, hyaluronic acid, and combinations thereof.
15. Device according to claim 1, wherein said mixture (M) further comprises an antioxidant agent.
16. After-insect bite method comprising the following steps in sequence: a) heating a part affected by the insect bite; and b) dispensing a predetermined amount of a mixture (M) of completely vegetal substances onto said heated part.
17. Method according to claim 16, comprising a step of awaiting between said heating and dispensing steps.
18. Method according to claim 16 or 17, wherein said part affected by the insect bite is heated to a denaturation temperature (Tden), varying from about 60 C. to about 90 C.
19. Method according to claim 16, wherein said predetermined amount of said mixture (M) dispensed onto the part interested by the insect bite is from about 0.02 to about 0.05 ml.
20. Method according to claim 17, wherein said awaiting step has a duration comprised between about 3 and about 10 seconds.
21. Method according to claim 16, wherein said dispensed mixture (M) consists of essential oils dispersed in an inert solvent.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
[0036] Further features and advantages of the present invention will become clearer from the following detailed description of a preferred embodiment thereof, made hereinafter as indicative and non-limiting example with reference to the attached drawings. In the drawings:
[0037]
[0038]
[0039]
[0040]
[0041]
DETAILED DESCRIPTION OF THE INVENTION
[0042] With reference to
[0043] The after-bite device, generally designated with the reference numeral 100, comprises a container body 10, preferably cylindrical in shape, a closing plug 20 of one end 12 of the container body 10 and an applicator head 30, extending from the other end 14 of the container body 10.
The closing plug 20 comprises a male threaded portion 22 to be screwed onto a corresponding female threaded portion 11 formed at the end 12 of the container body 10, inside the container body 10.
[0044] Similarly, the applicator head 30 comprises a male threaded portion 32 to be screwed onto a corresponding female threaded portion 13 formed at the end 14 of the container body 10, inside the container body 10.
[0045] Of course, the coupling between the container body 10 and, respectively, the closing plug 20 and the applicator head 30 can be carried out in any other known way suitable to the scope, for example by snap coupling, pressure coupling and the like.
[0046] The device 100 further comprises heating means 40 housed inside the container body 10 and which can be activated by switching on/off means of the device 100, for example a switch 70 provided externally to the container body 10. Such heating means 40 have the function to heat the part affected by the insect bite before applying onto said part a mixture M of completely vegetal substances, which will be described in greater detail in the following description.
[0047] The prior heating of the part affected by the bite increases, advantageously, the absorption capacity of the mixture M, more particularly of the essential oils contained therein, this resulting in a reduction, or a complete elimination, of the discomfort sensation generated by the bite.
[0048] Moreover, as already mentioned above, the heat produced by the heating means 40 denatures the anticoagulant and vasodilating protein present in the insect saliva and that the insect, typically a mosquito, injects under the skin.
[0049] As shown in greater detail in
[0050] The electrical resistance 40 is further supplied by respective supplying means, for example a battery 42 housed inside the container body 10. The battery 42 can be of the rechargeable type.
[0051] Preferably, the temperature of the resistance 40 must be maintained within a range of from about 60 C. to about 90 C. A temperature within the above range will be indicated, in the following, as denaturation temperature T.sub.den. In fact, it has been observed that the anticoagulant and vasodilating protein injected by the insect tends to denature at a temperature greater than 60 C., while in a short time a resistance temperature of 90 C. has been found to be the most suitable for increasing the thermal exchange with the part affected by the bite, meanwhile avoiding possible burns of the bitten subject.
[0052] To this end, the device 100 comprises a control unit 44, which in the embodiment shown consists of a printed circuit 44 housed inside the container body 10 between the closing plug 20 and the battery 42. More specifically, the control unit 44 is accommodated in a circular seat 16 formed in the inner surface of the container body 10.
[0053] After pressing the switch 70, the control unit 44 operates the resistance 40 until the denaturation temperature T.sub.den is reached and maintains this denaturation temperature T.sub.den for a predetermined time t.
[0054] To this end, the control unit 44 includes a timer, which is activated when the resistance 40 reaches the denaturation temperature T.sub.den and allows this temperature T.sub.den to be maintained for the predetermined time t, after which the electric resistance 40 is switched off.
[0055] Preferably, the device 100 further comprises indicator means, for example a LED (Light Emitting Diode) 72, provided externally to the container body 10 and configured to switch on when the device 100 is activated and subsequently to switch off when the time t has elapsed. Switching off the LED 72 informs the user that it is the time to dispense the mixture M on the part affected by the bite, as will be described in detail below.
[0056] An interchangeable reservoir 50 suitable for containing the mixture M of completely vegetal substances is also accommodated in the housing body 10.
[0057] Preferably, the reservoir 50 is placed within the container body 10 between the resistance 40 and the battery 42 and is in fluid communication with the applicator head 30 of the device 10 through a dispensing valve 52. The opening of the valve 52, which results in nebulization of a predetermined quantity of the mixture M onto the part affected by the bite, is controlled by the switch 70 or, in an alternative embodiment, by dedicated operating means, for example an additional switch also provided externally to the container body 10.
[0058] An insulating body 60 is preferably housed inside the container body 10 to isolate the battery 42 and control unit 44 from the resistance 40. Damaging heating or melting of plastic material and heat dispersion are thus prevented, with the heat being only directed on the part to be treated. In particular, a circular seat 62 for housing a terminal portion of the battery is formed in the insulating body 60.
[0059] The mixture M comprises essential oils dispersed in an inert solvent, typically water, extracts of natural substances, at least one stabilizer and at least one emulsifier.
[0060] Preferably, the mixture M further includes an antioxidant agent, such as ascorbic acid or vitamin C, to further stabilize the active ingredients present in the oils or vegetal extracts by means of an antioxidant process.
[0061] Essential oils, or ethereal oils, are substances of complex composition, present in the form of tiny droplets in flower petals, in fruit peels, in resin and bark of trees and roots of aromatic herbs and plants. In plants, in addition to promoting the pollination process, essential oils have a protective function against bacterial, fungi, and mold infections, meanwhile promoting healing of injured plant tissues.
[0062] These essential oils are, therefore, natural products which, once extracted, appear as oily, liquid, volatile substances and are scented as the plant from which they originate.
[0063] Since they are not water soluble, their mixture is dissolved in oil, to be then suspended, by means of a stabilizer, in water.
[0064] This advantageously allows to avoid the use of alcohol as a solvent, which is irritating and causes burning, especially in exposed areas, such as the skin after an insect bite.
[0065] The molecules of essential oils have a great affinity with human body tissues, i.e. they penetrate easily into the skin, through the skin pores, thus entering the systemic circulation through the blood, or through the lymph and interstitial fluid.
[0066] The function of essential oils suspended in the inert solvent varies from extract to extract, being a wide combination of said essential oils possible.
[0067] In the following, a list of essential oils and/or extracts that can be used in the device 100 of the present invention, together with properties and indications thereof, is provided.
[0068] Mimosa extract: healing, antiseptic, and dermo-purifying activity. Suitable for skin lesions, burns or erythema.
[0069] Calendula extract: re-epithelizing, healing, dermo-purifying, and insect repellent activity. Suitable for the treatment of burns or dermatoses.
[0070] Althea extract: emollient, antiseptic (disinfectant), and healing activity. Suitable for the treatment of infections.
[0071] Alcanna extract: re-epithelizing, healing activity. Suitable for the treatment of skin lesions.
[0072] Bugleweed extract: antiseptic and healing activity. Suitable for the treatment of skin lesions.
[0073] Goji berry extract: high content of vitamin C and also B. Antioxidant, tonic, dermo-purifying activity. Suitable for the treatment of dermatosis.
[0074] Blackcurrant extract: immune-stimulating and dermo-purifying activity. Suitable for the treatment of dermatosis, and also to relieve itching.
[0075] Plantago Lanceolata extract: hemostatic, coagulant, antiseptic and dermo-purifying activity. Suitable for the treatment of infections or dermatoses.
[0076] Jujube extract: it contains vitamin C and A. Moisturizing and dermo-purifying activity. Suitable for the treatment of dermatosis or itching.
[0077] Blumea essential oil: it contains many other essential oils having beneficial properties, such as linalool (about 19%, highly present in rose wood) and limonene. Suitable for the treatment of skin lesions.
[0078] Lavender essential oil: countless chemical analyzes on lavender essential oil have highlighted the many and varied components, each of which can act specifically on different problems or symptoms. Among these, the following are to be mentioned: linalyl acetate, linalool, lavandulyl acetate, lavandulol, and cineole which is strongly antiseptic, dermo-purifying and healing, if applied to burns, wounds, sores and insect bites. It also has a soothing action on itching, and is used to treat dermatosis.
Preferably, to increase the effectiveness of the mixture M, other components, also of completely vegetal origin, and always at low percentages, for example ranging from 0.01% to 1%, are added to it.
[0079] Such additional components include: menthyl lactate, rennet, milk whey, vitamin D, vitamin E, hyaluronic acid and combinations thereof.
[0080] Menthyl lactate is produced from two natural ingredients, namely menthol and lactic acid. It has high ability to relieve itching.
[0081] Rennet has healing and dermo-purifying properties, and it is particularly suitable for skin lesions or dermatosis. Milk whey has moisturizing, nutrient, emollient and hydrating properties, and it is particularly suitable for counteracting signs of time and skin dryness.
[0082] Vitamin D has the essential role to promote calcium fixation in the bones. It is also able to act in other districts of the human body, such as muscles, eyes, heart, lungs, or on cell proliferation, as its receptor is present everywhere in our body. Vitamin D also plays an important role, taking part to the synthesis of ceramides, in a better differentiation of the stratum corneum cells, and the maturation of the binding that holds the skin layers together: it has therefore a healing activity.
[0083] Vitamin E has soothing, moisturizing, and elasticizing properties. It is particularly effective in the treatment of acne and eczema, where it favors healing. It contains tocopherol, a strong lipid soluble antioxidant.
Hyaluronic acid is the natural component of connective tissues and, in the skin, plays an important structural role, along with collagen and elastin. It has no contra-indications and promotes healing.
Example 1: Mixture M
[0084] In the following Table 1, a formulation example of the mixture M to be used in the device 100 according to the invention is provided.
TABLE-US-00001 TABLE 1 Component Property Active ingredients % water Inert solvent 42.5 peg 40 idrogenated oil solubiliser 20 peg 6 caprylic capric emulsifier 5 triglycerides surfactant glycerin wetting 5 disodium surfactant 5 cocoamphodiacetate lemon-orange juice preservative, 5 antioxidant menthyl lactate cooling 1 officinalis calendula oil re-epithelizing, unspecified bitter substance, malic 2 healing, acid, triterpenic glycosides, dermo-purifying, triterpenic alcohols, sterols, skin-protecting, carotenoids, flavonoids and antiseptic, coumarins, essential oil, insect repelling, polysaccharides, mucilage, gums, immune-stimulant resins, phenols, pyrogenic tannins, vitamin C, manganese seabuck seed oil healing, oil with unsaturated fatty acids, 2 antioxidant, vitamin C, carotenoids, triterpenes, antiseptic, sterols, flavonoids, oxalic acids, immune-stimulant, citric, tartaric, chlorogenic, malic, vasoprotective succinic, tocopherol, pectin cetrimonium bromide cationic surfactant 1 in case of need to maintain the pH stable disodium edta buffer 1 lavender oil antiseptic, dermo- linalool, linalyl acetate, limonene, 0.5 puriying, calming, cineole, camphor, -terpineol, - skin-protective, ocimens; pernicious alcohol, insect repelling tannins, ursolic acid, flavonoids, bitter substances vitamin D healing, 0.2 antimicrobial, melanin regulator, anticancer activity, it facilitates endorphin release goji berry extract or juice antioxidant, amino acids in large quantities, 0.1 dermo-purifying, betaine pigments, -carotene, skin-protective, vitamins B1, B2, C, nicotinic acid, tonic, antiseptic, scopoletin, taurine, trace minerals, healing, immune- cinnamic acid, fats, sugars stimulant, re- epithelizing for lavanda: linalool, possible oil and/or list B of cosmetic supplements: few 0.1 limonene extract allergens consumer reports, low risk
[0085] Of course, the percentages reported in Table 1 are only indicative, since the amount of the mixture components is potentially variable based on the strengthen of the purchased product.
[0086] With reference to
[0087] It is assumed that a subject has been bitten by an insect, for example a common mosquito.
[0088] As disclosed above, during the bite, the mosquito injects into the human body an anticoagulant and vasodilating protein present in its saliva. As this protein is extraneous to the body of the bitted subject, it is detected as an antigen and causes an obvious immune response, which manifests in the appearance of a wheal and an itching sensation.
[0089] Once the wheal appears, the bitten subject can use the device 100 not only to relieve the annoying itching, but also to speed up the curing and healing process of the part affected by the bite.
[0090] To this end, the bitten subject puts the applicator head 30 of the device 100 in contact with the part affected by the bite and activates the device 100 by operating the switch 70 (step S1).
[0091] Following the activation of the device 100, the control unit 44 activates the resistance 40 until the denaturation temperature T.sub.den is reached (step S2).
[0092] Upon reaching the temperature T.sub.den (step S3, YES), the control unit 44 activates the timer 46 (step S4) so that this temperature T.sub.den is maintained for a predetermined time t of from about 3 seconds to about 10 seconds, preferably of 5 seconds.
[0093] After the time t has lapsed (step S5, YES), the control unit 44 controls the switching off of the resistance 40 (step S6), with consequent switching off of the LED 72. This advantageously allows to obtain an effective range of heat exposure of the part affected by the bite. In fact, heat applied by the device 100 causes skin pores to dilate, thus making the latter more permeable to the subsequent passage of the substances contained in the mixture M.
[0094] Once it is heated to the temperature T.sub.den for the predetermined time t, the part is then ready to receive the mixture M contained in the reservoir 50 of the device 100.
[0095] At this point, the subject may press again the switch 70 or, according to a further embodiment, an additional switch also provided outside the device 100 (step S7), thereby opening the valve 52 of the reservoir 50 and subsequent nebulizing a predetermined dose, preferably 0.02-0.05 ml, of the mixture M (step S8).
[0096] According to a further embodiment, the opening of the valve 52 is automatically controllable by the control unit 44, specifically by the timer switching off, without a further pressure of the switch 70 being necessary by the bitten subject.
[0097] The mixture M, and more particularly the essential oils present therein, penetrate optimally in the heated skin, resulting in the restoration of the normal condition of the part affected by the bite, that is, the disappearance of the wheal. Furthermore, thanks to the presence of menthyl lactate in the mixture M, the bitten subject feels on the skin a sense of relief and freshness that eliminates any feeling of discomfort related to the mosquito bite or the use of heat.
Example 2
[0098] In the following example, a wheal W caused by a mosquito bite was treated by using a heat emitting device according to the prior art (Comparative 1), a mixture consisting of essential oils dispersed in an inert solvent (Comparative 2), and a device 100 according to the present invention filled with a mixture M consisting of essential oils dispersed in an inert solvent (Invention).
[0099]
[0100] The wheal size was observed in two instants following the treatment, respectively after 7 minutes and 15 minutes. In the following Table 2 the results of the above observations are reported.
TABLE-US-00002 TABLE 2 Treatment 7 min 15 min Comparative 1 The wheal size was unchanged The wheal size was slightly reduced Comparative 2 The wheal size was unchanged The wheal size was unchanged Invention The wheal disappeared
[0101] By treating the wheal W with the heat emitting device, after 7 minutes the wheal size was unchanged (
[0102] By treating the wheal W with the mixture consisting of essential oils dispersed in an inert solvent, after 7 minutes the wheal size was unchanged and after 15 minutes the wheal size was still unchanged.
[0103] Finally, by treating the wheal W with the device 100 according to the present invention (
[0104] The above disclosed Example 2 clearly shows that the interaction between the heat emitted by the device 100 and the mixture of completely vegetal substances M contained in the device 100 produces the synergistic effect of speeding up the curing and healing process of the injured part, as well as completely denaturing the substances that cause itching and irritation.
[0105] From the description, they are clear the features of the after-insect bite device and the steps of after-insect bite method of the present invention, as well as the relative advantages thereof.
Further variants of the embodiments described above are possible without departing from the teachings of the invention.