COMPOSITION FOR THE TREATMENT OF ACNE

Abstract

The present invention describes a cosmetic or dermatological composition for use in the antibacterial and/or anti-inflammatory treatment comprising a combination of vegetal extracts titrated in salicin and 1,2-alkanediols, preferably 1, 2-decanediol and willow bark (Salix alba) extract.

Claims

1. Cosmetic or dermatological composition for use in the antibacterial and/or anti-inflammatory treatment of acne comprising 1,2-decanediol and Salix alba extract.

2. Composition for use according to claim 1, characterized in that the proportion of 1,2-decanediol is in the range between 0.001% (w/w) and 10% (w/w), In particular in the range between 0.01% (w/w) and 5% (w/w), based on the total mass of the preparation.

3. Composition for use according to claim 1, characterized in that the proportion of Salix alba extract is in the range between 0.001% (w/w) and 10% (w/w), preferably between 0.01% (w/w) and 5% (w/w), based on the total mass of the preparation.

4. Composition for use according to claim 1, characterized in that the ratio between Salix alba extract and 1,2-Decanediol is between 1:10 and 10:1; preferably between 1:5 and 5:1, more preferably 1:1.

5. Composition for use according to claim 1 in the form of a surfactant system, water-in-oil emulsion, oil-in-water emulsion, serum, gel, oil, aqueous solution, hydroalcoholic solution, anhydrous sticks, compact founding powder, lotion, milk, suncream, after sun product or camouflage product.

6. Composition for use according to claim 1 additionally comprising customary auxiliaries and additives.

7. Composition for use according to claim 1, characterized that it is a suncream comprising 0.3% (w/w) Salix alba extract, 0.3% (w/w) 1,2-decanediol, up to 10% (w/w) of a mixture of Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (46-55%)/Aqua (33.9-47.7%)/Decyl Glucoside (6-10%)/Propylene Glycol 0.2-0.6%)/Xanthan Gum (0.1-0.5%), up to 0.5% (w/w) Magnesium Aluminum Silicate, up to 5% (w/w) of a mixture of Titanium Dioxide (75%)/Silica (10%)/Dimethicone (15%), up to 8% (w/w) Ethylhexyl Methoxycinnamate, up to 5% (w/w) Dicaprylyl Carbonate, up to 5% (w/w) Avobenzone, up to 2% (w/w) Ethylhexyl Triazone.

8. Composition for use according to claim 1, characterized that it is a suncream comprising 0.3% (w/w) Salix alba extract, 0.3% (w/w) 1,2-decanediol, up to 10% (w/w) of a mixture of Aqua (37-46%)/Tris-Biphenyl Triazine (47-53%)/decyl glucoside (6.5-8.5%)/disodium phosphate (0.2%-0.6%)/butylene glycol (0.2%-0.6%)/xanthan gum (0.1%-0.3%), up to 0.5% (w/w) Magnesium Aluminum Silicate, up to 5% (w/w) of a mixture of Titanium Dioxide (75%)/Silica (10%)/Dimethicone (15%)/up to 8% (w/w) Ethylhexyl Methoxycinnamate, up to 5% (w/w) Dicaprylyl Carbonate, up to 5% (w/w) Avobenzone, up to 2% (w/w) Ethylhexyl Triazone.

9. Composition for use according to claim 1, characterized that it is a detergent comprising 0.01 to 0.9% (w/w) Salix alba extract, 0.01 to 3% (w/w) 1,2-decanediol, 0.01 to 0.1% (w/w) phytosphingosine HCl, up to 6% (w/w) sodium cocoamphoacetate, up to 8% (w/w) disodiumlaureth sulfosuccinate, up to 1% (w/w) polyquarternium-10.

10. Composition for use according to claim 1, characterized that it is a moisturizing cream comprising 0.01 to 0.3% (w/w) Salix alba extract, up to 0.9% (w/w) 1,2-decanediol, 0.2 to 0.9% (w/w) sodium hyaluronate, 1 to 5% (w/w) dicaprylyl ether, up to 2% (w/w) aluminium starch octenylsuccinate, up to 0.5% (w/w) sodium phytate.

11. Composition for use according to claim 1, characterized that it is a CC cream comprising 0.5% (w/w) Salix alba extract, 1% (w/w) 1,2-decanediol, up to 2% (w/w) of a mixture of Methylpropanediol (80%)/Caprylyl Glycol (15%)/Phenylpropanol (5%), up to 5% (w/w) titanium dioxide, up to 2% (w/w) of a mixture of Mica (44-54%)/Iron Oxides (36-50%)/Titanium Dioxide (2-8%), up to 0.5% (w/w) magnesium sulfate heptahydrate.

12. Composition for use according to claim 1, characterized that it is a liquid detergent comprising 0.01% (w/w) Salix alba extract, 1% (w/w) 1,2-decanediol, up to 1% (w/w) of hydroxypropyl guar hydroxypropyltrimonium chloride, up to 10% (w/w) sodium cocoamphoacetate, up to 5% of a mixture of Methylpropanediol (80%)/Caprylyl Glycol (15%)/Phenylpropanol (5%).

13. Composition for use according to claim 1, characterized that it is a gel comprising 0.5% (w/w) Salix alba extract, 0.5% (w/w) 1,2-decanediol, up to 2% (w/w) caprylyl glycol, up to 3% (w/w) polyacrylate crosspolymer-6, up to 1% (w/w) niacinamide.

14. Composition for use according to claim 1, characterized that it is a serum comprising 0.3% (w/w) Salix alba extract, 1% (w/w) 1,2-decanediol, up to 4% (w/w) of a mixture of Polyglyceryl-6 Stearate (85-98%)/Polyglyceryl-6 Behenate (2-15%), up to 5% (w/w) caprylyl glycol, up to 2% (w/w) salicylic acid, up to 2% (w/w) aluminium starch octenylsuccinate, up to 2% (w/w) dipotassium glycirrhizinate.

Description

EXPERIMENTAL PART

Determination of MIC and MBC on Gram Positive Bacteria

Aim of the Test

[0027] The aim of the test was to determine the antimicrobial activity of one or more samples against a micro-organism. The values obtained must be considered characteristic of the test sample for a determined microbial species under determined test conditions.

Description of the Method

[0028] A series of test tubes was prepared containing the culture broth inoculated with the test micro-organism and the substance to be tested was introduced at decreasing scalar concentrations.

[0029] The cultures were incubated at the optimal temperature and under optimal growth conditions of the preselected micro-organism and for a sufficient period of time to demonstrate development.

[0030] The test tubes in which the microbial population developed were then determined by observing visually the turbidity that is indicative of growth. Test tubes in which the substance is present at a sufficient concentration to inhibit growth remain clear. When the nature itself of the sample prevents visual reading or if it is wished to determine whether the lack of development is due to a microbiostatic or microbicidal action, transfers are made to appropriate agar media for confirmation.

Criteria of Interpretation

[0031] The concentration of sample at which growth of the micro-organisms is inhibited is considered to be the Minimum Inhibitory Concentration (MIC), while that at which viable micro-organisms are no longer present is considered to be the Minimum Bactericidal Concentration (MBC)

A) Evaluation of the Antibacterial Activity of Different Substances Against Staphylococcus Species

[0032] A test to evaluate antibacterial activity against Gram positive bacteria was conducted evaluating the following substances:

[0033] Bakuchiol, Lactoferrin, Lauric acid, Resveratrol, Salix alba extract.

[0034] The antibacterial activity of these substances against Staphylococcus aureus acnes ATCC 25923 and Staphylococcus epidermidis ATCC 12228 was tested according to the above-described method. The results are shown in Table 1.

TABLE-US-00001 TABLE 1 Staphylococcus Staphylococcus aureus epidermidis ATCC 25923 ATCC 12228 MBC MBC MIC (g/ml) (g/ml) MIC (g/ml) (g/ml) Bakuchiol 6.25 100 6.25 100 Lactoferrin >20000 >20000 Lauric Acid 250 1.000 500 1000 Resveratrol 1000 >100000 250 >100000 Salix alba extract 30000 100000 30000 100000

[0035] Minimum Inhibition Concentration (MIC) and Minimum Bactericide Concentration (MBC) of different substances against Staphylococcus aureus acnes and Staphylococcus epidermidis

[0036] The test showed poor activity of Salix alba extract against Gram positive bacteria with respect to other substances tested.

B) Evaluation of the Antibacterial Activity of Different Substances Against P. acnes

[0037] In a further set of experiments we tested the antibacterial activity of Salix alba extract and 1,2-decanediol, a substance which is known to show antibacterial activity against P. acnes, alone and in combination according to the above-described method.

[0038] The microbial strain used was Propionibacterium acnes ATCC 11827 titrated at a concentration of 2.6104 cells per milliliter of medium.

[0039] The result is shown in Table 2.

TABLE-US-00002 TABLE 2 Propionibacterium acnes MIC (g/ml) MBC (g/ml) Salix alba extract 1560 3120 1,2-decanediol 620 1250 Salix alba extract + 620 620 1,2-decanediol (1:1) benzoyl peroxide 480 480

[0040] Minimum Inhibition Concentration (MIC) and Minimum Bactericide Concentration (MBC) of 1,2-Decanediol and Salix alba extract against Propionibacterium acnes

[0041] Salix alba extract alone shows only poor antibacterial activity.

[0042] 1,2-decanediol is known to be effective against P. acnes.

[0043] The combination (1:1) of Salix alba extract and 1,2-decanediol surprisingly displayed a synergistic antibacterial effect against P. acnes.

[0044] A combination of 1,2-decanediol and Salix alba extract is capable to obtain the same MIC of the double concentration of 1,2-decanediol and to improve dramatically its MBC.

[0045] The selected order degree of the association is in line with benzoyl peroxide that is commonly known as strong antibacterial agent against P. acnes.

In Vitro Evaluation of the Anti-Inflammatory Activity of Salix alba Extract and 1,2-Decanediol

[0046] The aim of the test was the evaluation of the anti-inflammatory activity of Salix alba extract, 1,2-decanediol and their combination by means of the study of TNFalpha, IL1alpha, IL8 synthesis modulation in a biological experimental model (keratinocyte cell culture HaCat).

[0047] TNFalpha, IL1alpha, IL8 are inflammatory mediators related to the acneic process.

[0048] Keratinocyte cell culture were selected as experimental model on the base that the acneic process is performed inside the sebaceous glands follicle, a tissue composed by keratinocytes.

[0049] In order to stimulate the inflammatory process in our experimental model, lipopolysaccharides (LPS) were selected. LPS are pro-inflammatory mediators secreted by bacteria, e.g. by P. acnes.

[0050] 1,2-decanediol (SMAL) was emulsified with corn oil (37 C.) in mechanical agitation and addition of culture medium, starting from the following ratio: 0.05 g emulsified with 100 l corn oil in a final volume of culture medium of 1 ml (37 C.).

[0051] Salix alba extract (WMAL) was direct diluted in culture medium, starting from the following ratio: 0.05 g in 1 ml (37 C.); subsequent dilutions in culture medium (37 C.).

[0052] For the test execution, human keratinocytes (HaCat) were treated with LPS (Lipopolysaccharide from Escherichia coli, 10 ng/ml) and with tested product at 3 concentrations, chosen among non-cytotoxic ones after a preliminary cytotoxicity test.

[0053] At the end of the monitored experimental period, cytokine levels were measured by means of ELISA assay.

[0054] Results were compared to negative control (cells not subjected to LPS, CTR) and positive control (cells treated with LPS, CTR+).

[0055] A preliminary cytotoxicity test was performed on the two products by using a concentration range from 5.0% to 0.0012% (serial dilution 1:2). According to obtained results, the following concentrations were chosen for the analysis of the antinflammatory activity:

1,2-decanediol (SMAL): 0.002%
Salix alba extract (WMAL): 0.04%-0.02%-0.01%

[0056] A second cytotoxicity test was performed on the mix of the two raw materials preliminary to the beginning of the test to verify the action synergism in the antinflammatory activity; tested concentrations were the following:

SMAL 0.002%+WMAL: 0.04%-0.02%-0.01%

[0057] Culture media of controls and cells treated with tested product were used for the dosage of pro-inflammatory cytokines TNFalpha, IL1alpha and IL8 by means of ELISA method.

[0058] Commercial ELISA kits were used for the determination of cytokine quantity.

[0059] The quantitative determination uses a calibration curve made-up of standard known and growing concentrations of standard cytokine.

[0060] The data obtained in the different experimental groups were subjected to statistical analysis and compared according to t-test. The variations are considered significant for p<0.05.

[0061] In table 3 below the data obtained for each tested series are reported.

[0062] The results are expressed as cytokine released into the medium during the experimental period (mean valuedev.st.) and as mean % variation compared to the controls.

[0063] In order to compare the two different work sessions, the obtained data were normalized in a 0-100% scale, in which CTR is 0 and CTR+ is 100%; all the other data were calculated in this interval.

[0064] On these data, statistical analysis by t-test was performed and variations are considered significant for p<0.05.

[0065] On the base of the results obtained, it is observed that SMAL and WMAL are able to significantly reduce the LPS-induced release of the inflammation markers TNFalpha, IL1alpha and IL8, which are all related to acne.

[0066] For all substances analyzed, the substances WMAL and SMAL in combination show a synergistic effect.

TABLE-US-00003 TABLE 3 Normalized data 0-100% T-test vs T-test vs T-test vs CTR+ CTR+ dev std CTR+ +WMAL +SMAL TNF-ALPHA CTR 0 CTR+ 100.00% 6.2% WMAL 0.4% 32.94% 22.2% 0.0545 SMAL 0.02% 18.45% 3.9% 0.0040 WMAL 0.4% + 25.00% 8.5% 0.0042 0.0751 0.0224 SMAL 0.02% IL-8 CTR 0 CTR+ 100.00% 9.4% WMAL 0.4% 17.77% 0.4% 0.0064 SMAL 0.02% 34.56% 0.3% 0.0101 WMAL 0.4% + 13.76% 2.9% 0.0011 0.0044 0.0019 SMAL 0.02% IL-6 CTR 0 CTR+ 100.00% 45.6% WMAL 0.4% 75.81% 111.8% 0.8035 SMAL 0.02% 61.69% 106.6% 0.6864 WMAL 0.4% + 21.43% 7.2% 0.0017 0.3444 0.3861 SMAL 0.02%

[0067] Dosage of cytokine in cell culture CTR, CTR+, treated with SMAL, WMAL and their associations. The results are expressed as mean valuedev.st. (expressed in ng/L) and as mean % variation compared to the controls.

[0068] Formulations can be of various nature both water-based, hydro-alcohol and anhydrous. Among the most commonly used include: surfactants systems (including even such as shampoo, bubble bath, shower gel, liquid soaps and solid soaps, micellar waters, liquid detergents), water-in-oil emulsions, oil-in-water emulsions, serums, gels, oils, aqueous solutions, hydroalcoholic solutions, anhydrous sticks, compact founding powders, lotions, milks, suncreams, after sun products and camouflage products (i.e. CC creams, BB creams).

[0069] It is optionally possible and advantageous to use the compositions according to the invention as a base for pharmaceutical formulations.

[0070] It is of course known to the person skilled in the art that cosmetic compositions are usually inconceivable without the customary auxiliaries and additives. Among these are included, for example, consistency-imparting agents, fillers, perfume, colorants, emulsifiers, additional active compounds such as vitamins or proteins, sunscreens, stabilisers, insect repellents, alcohol, water, salts, substances having proteolytic or keratolytic activity, thickeners, emollients, fatty acids, chelating agents, soothing agents, glycols, colorants, buffering substances.

[0071] The willow bark extract is prepared according to the Ph.Eur. monograph Extracta. Whole or fragmented dried bark of young branches or whole dried pieces of current year twigs of various species of genus Salix including S. purpurea L., S. saphnoides Vill. And S. fragilis L. are extracted with water and/or ethanol. The total content of salicylic derivatives expressed in salicin has to be at least 5%; preferably between 10 and 20%.

[0072] The Salix alba extract according to the present invention has to be titrated to a total concentration of salicylic derivatives expressed as salicin not less than 20% (w/w).

[0073] The ratio between Salix alba extract and 1,2-decanediol is between 1:100 and 100:1, or between 1:50 and 50:1, or between 1:10 and 10:1, preferably 1:5 and 5:1; more preferably 1:1.

[0074] The overall amount of Salix alba extract in the formula is in a range between 0.001% and 10%, preferably between 0.01% (w/w) and 5% (w/w), more preferably between 0.3% (w/w) and 1% (w/w).

[0075] The overall amount of 1,2-decanediol in the formula is in a range between 0.001% (w/w) and 10% (w/w), preferably between 0.01% (w/w) and 5% (w/w), more preferably between 0.3 (w/w) and 1% (w/w).

EXAMPLES

[0076] The following examples shall not represent a restriction of the invention.

Example 1

Suncream

[0077]

TABLE-US-00004 INCI NAME % (w/w) Avobenzone 0-5 Glycerol 0-5.00 Panthenol 0-1.00 Disodium EDTA 0.10 Glyceryl Stearate, PEG-100 Stearate 1-5.00 (50%:50%) (Arlacel 165V P) 4-Methylbenzylidene Camphor 1-4.00 Citrus Aurantius Amara 0-1 Xanthan Gum 0-1 Ascorbyl Tetraisopalmitate 0.20 Polyacrylamide (45%), C13-14 0-2.00 Isoparaffin (25%), Laureth-7 (8%), Aqua (22%) (Sepigel 305) Methylene Bis-Benzotriazolyl 0-2.00 Tetramethylbutylphenol, Aqua, Decyl Glucoside, Propylene Glycol, Xanthan Gum (Tinosorb A2B) Ethylhexyl Methoxycinnamate 0-8.00 Niacinamide 0-1 Magnesium Aluminum Silicate 0-0.50 Dicaprylyl Carbonate 1-5.00 1,2-Hexanediol, Caprylyl Glycol 0.50 (50%:50%) (Symdiol 68) Soy Isoflavones 0.30 Ethylhexyl Triazone 0-2.00 Titanium Dioxide (75%), Silica (10%), 0-5 Dimethicone (15%) (Parsol TX) 1,2-Decanediol 0.30 Salix alba (Willow) Bark Extract 0.30 Tocopheryl Acetate 0.50 Butylated hydroxytoluene 0-0.05 Hydroxyacetophenone 0-0.50 Demin. H.sub.2O ad 100.00

Example 2

Serum

[0078]

TABLE-US-00005 INCI NAME % (w/w) Sodium Hydroxide 0-8 Glycolic Acid 0-20.00 Lactic Acid 0-3 Niacinamide 1.00 Caprylyl Glycol 0-5.00 Xanthan Gum 0.10 Polyacrylate Crosspolymer-6 2.20 Dicaprylyl Ether 0-4.00 Salicylic Acid 0-2 1,2-Decanediol 1.00 Polyglyceryl-6 Stearate (85-98%), 0-4 Polyglyceryl-6 Behenate (2-15%) (Tego Care PBS 6) Salix alba (Willow) Bark Extract 0.30 Aluminum Starch Octenylsuccinate 0-2.00 Dipotassium Glycirrhyzinate 0-2 Sodium Phytate, Aqua, Alcohol 0.10 Demin. H.sub.2O ad 100.00

Example 3

Hydrating Cream

[0079]

TABLE-US-00006 INCI NAME % (w/w) Disodium EDTA 0.10 Glycerol 0-7.00 Sodium Hyaluronate 0-1 Niacinamide 1.00 Caprylyl Glycol 0-2.00 Xanthan Gum 0.10 Polyacrylate Crosspolymer-6 0-3.00 Dicaprylyl Ether 0-5.00 1,2-Decanediol 0.30 Polyglyceryl-6 Stearate (85-98%), 2.50 Polyglyceryl-6 Behenate (2-15%) (Tego Care PBS 6) Salix alba (Willow) Bark Extract 0.3 Lactic Acid 0-1 Sodium Phytate (48-52%), Aqua (48-52%), 0.05 Alcohol (1%) (Dermosoft PA 3) Demin. H.sub.2O ad 100.00

Example 4

Gel

[0080]

TABLE-US-00007 INCI NAME % (w/w) Disodium EDTA 0.10 Glycerol 0-3.00 Niacinamide 1.00 Caprylyl Glycol 0-2.00 Xanthan Gum 0.20 Polyacrylate Crosspolymer-6 0-3.0 1,2-Decanediol 0.50 Salix alba (Willow) Bark Extract 0.50 Lactic Acid 0.50 Sodium Phytate (48-52%), Aqua (48-52%), 0.10 Alcohol (1%) (Dermosoft PA 3) Demin. H.sub.2O ad 100.00

Example 5

Liquid Detergent

[0081]

TABLE-US-00008 INCI NAME % (w/w) Disodium EDTA 0.10 Glycerol 0-4.00 Hydroxypropyl Guar 0-1.0 Hydroxypropyltrimonium Chloride (Jaguar C162) Niacinamide 0.30 Methylpropanediol (80%), Caprylyl 0-5.0 Glycol (15%), Phenylpropanol (5%) (Dermosoft OMP) Xanthan Gum 0.30 Sodium Cocoamphoacetate 0-10.0 Disodium Laureth Sulfosuccinate 0-10.0 1,2-Decanediol 1.00 PEG-40 Hydrogenated Castor Oil 1.00 Salix alba (Willow) Bark Extract 0.01 Lactic Acid 1.00 Demin. H.sub.2O ad 100.00

Example 6

CC Cream

[0082]

TABLE-US-00009 INCI NAME % (w/w) Aqua 56.00 Glycerol 2.00 Niacinamide 0.50 Salix alba (Willow) Bark Extract 0.50 Magnesium Sulfate Heptahydrate 0.50 Methylpropanediol (80%), Caprylyl 2.00 Glycol (15%), Phenylpropanol (5%) (Dermosoft OMP) Cetyl Dimethicone 2.00 Octyldodecanol 10.00 Ethylhexyl Palmitate 8.00 Dimethicone 1.50 Hydrogenated Castor Oil 1.50 1,2-Decanediol 1.00 Cetyl PEG PPG-10/1 Dimethicone 2.50 (Abil EM 90) Titanium dioxide 5.00 Tocopheryl Acetate 1.00 Mica (48-59%), Titanium Dioxide (41-52%) 4.00 (Timica Terra White) Mica (44-54%), Iron Oxides (36-50%), 2.00 Titanium Dioxide (2-8%) (Timica Terra Brown) Demin. H.sub.2O ad 100.00

Example 7

Moisturizing Cream

[0083]

TABLE-US-00010 INCI NAME % (w/w) Disodium EDTA 0-0.10 Glycerin 0-6.00 Niacinamide 0-1.00 Sodium Phytate 0-0.05 Sodium Hyaluronate 0.2-0.9 Salix alba (Willow) Bark Extract 0.01-0.3 Caprylyl Glycol 0.5-1.5 Xanthan Gum 0-0.30 Polyacrilate Cosspolymer-6 0-1.50 Dicaprylyl Ether 1-5.00 1,2-Decanediol 0-0.9 Polyglyceryl-6 Stearate (85-98%), 2.50 Polyglyceryl-6 Behenate (2-15%) (Tego Care PBS 6) Aluminum Starch Octenylsuccinate 0-2.00 Lactic Acid 0-0.15 Demin. H.sub.2O ad 100

Example 8

Detergent

[0084]

TABLE-US-00011 INCI NAME % (w/w) Glycerol 0.1-2.00 Disodium EDTA 0-0.10 Niacinamide 0.1-0.90 Phytospingosine HCl 0.01-0.1 1,2-Decanediol 0.01-3 Salix alba (Willow) Bark Extract 0.01-0.9 PEG-40 Hydrogenated Castor Oil 0-1.00 Polyquaternium-10 0-1 Sodium Cocoamphoacetate 1-6.00 Disodium Laureth Sulfosuccinate 1-8.00 Methylpropanediol (80%), Caprylyl 1-2.50 Glycol (15%), Phenylpropanol (5%) (Dermosoft OMP) Lactic Acid 0.01-0.90 Demin. H.sub.2O ad 100.00

Example 9

Suncream

[0085]

TABLE-US-00012 INCI NAME % (w/w) Avobenzone 0-5 Glycerol 0-5.00 Panthenol 0-1.00 Disodium EDTA 0.10 Glyceryl Stearate, PEG-100 Stearate 1-5.00 (50%:50%) (Arlacel 165V P) 4-Methylbenzylidene Camphor 1-4.00 Citrus Aurantius Amara 0-1 Xanthan Gum 0-1 Ascorbyl Tetraisopalmitate 0.20 Polyacrylamide (45%), C13-14 0-2.00 Isoparaffin (25%), Laureth-7 (8%), Aqua (22%) (Sepigel 305) Methylene Bis-Benzotriazolyl 0-10.00 Tetramethylbutylphenol (46-55%), Aqua (33.9-47.7%), Decyl Glucoside (6-10%), Propylene Glycol 0.2-0.6%), Xanthan Gum (0.1-0.5%) (Tinosorb M) Ethylhexyl Methoxycinnamate 0-8.00 Niacinamide 0-1 Magnesium Aluminum Silicate 0-0.50 Dicaprylyl Carbonate 1-5.00 1,2-Hexanediol (and) Caprylyl Glycol 0.50 (50%:50%) (Symdiol 68) Soy Isoflavones 0.30 Ethylhexyl Triazone 0-2.00 Titanium Dioxide (75%), Silica (10%), 0-5 Dimethicone (15%) (Parsol TX) 1,2-Decanediol 0.30 Salix alba (Willow) Bark Extract 0.30 Tocopheryl Acetate 0.50 Butylated hydroxytoluene 0-0.05 Hydroxyacetophenone 0-0.50 Demin. H.sub.2O ad 100.00

Example 10

Suncream 2

[0086]

TABLE-US-00013 INCI NAME % (w/w) Avobenzone 0-5 Glycerol 0-5.00 Panthenol 0-1.00 Disodium EDTA 0.10 Glyceryl Stearate, PEG-100 Stearate 1-5.00 (50%:50%) (Arlacel 165V P) 4-Methylbenzylidene Camphor 1-4.00 Citrus Aurantius Amara 0-1 Xanthan Gum 0-1 Ascorbyl Tetraisopalmitate 0.20 Polyacrylamide (45%), C13-14 0-2.00 Isoparaffin (25%), Laureth-7 (8%), Aqua (22%) (Sepigel 305) Aqua (37-46%), Tris-Biphenyl Triazine 0-10.00 (47-53%), decyl glucoside (6.5-8.5%), disodium phosphate (0.2%-0.6%), butylene glycol (0.2%-0.6%), xanthan gum (0.1%-0.3%) (Tinosorb A2B) Ethylhexyl Methoxycinnamate 0-8.00 Niacinamide 0-1 Magnesium Aluminum Silicate 0-0.50 Dicaprylyl Carbonate 1-5.00 1,2-Hexanediol (and) Caprylyl Glycol 0.50 (50%:50%) (Symdiol 68) Soy Isoflavones 0.30 Ethylhexyl Triazone 0-2.00 Titanium Dioxide (75%), Silica (10%), 0-5 Dimethicone (15%) (Parsol TX) 1,2-Decanediol 0.30 Salix alba (Willow) Bark Extract 0.30 Tocopheryl Acetate 0.50 Butylated hydroxytoluene 0-0.05 Hydroxyacetophenone 0-0.50 Demin. H.sub.2O ad 100.00