Powder for dental powder blasting

Abstract

The present invention relates to calcium carbonate particles, a powder mixture including such particles and a tooth cleaning method wherein the particles or powder mixture are used.

Claims

1. A combination tooth cleaning and remineralization method comprising the steps of: a. mixing by means of a powder-jet device (i) a dry powder comprising calcium carbonate particles that are at least partially coated with an alkali metal fluoride with (ii) air to form a powder/air mixture; and b. using said powder-jet device, powder blasting onto a tooth surface said powder/air mixture and water, wherein said powder/air mixture abrasively cleans said tooth surface; and said powder/air mixture and water form a slurry into which fluoride ion from said alkali metal fluoride is immediately released to thereby react with said calcium carbonate particles so as to enable remineralization of said tooth surface.

2. The method according to claim 1, wherein said alkali metal fluoride is sodium fluoride.

3. The method according to claim 2, wherein said calcium carbonate particles of step a have a mean particle size in the range of about 10 m to about 200 m.

4. The method according to claim 1, wherein the amount of said alkali metal fluoride coated onto said calcium carbonate particles in step a ranges from about 1,000 ppm to about 20,000 ppm relative to the weight of said calcium carbonate particles prior to coating.

5. The method according to claim 1, wherein said dry powder further contains from about 1 wt. % to about 20 wt. % of alditol based on the total weight of said dry powder.

6. The method according to claim 1, wherein said calcium carbonate particles of step a are at least partially coated with both said alkali metal fluoride and an alditol.

7. The method according to claim 6, wherein the alditol is xylitol.

8. The method according to claim 1, wherein said method further comprises performance of the following steps prior to step a: (i) spraying uncoated calcium carbonate particles with a solution containing said alkali metal fluoride and a solvent and then (ii) evaporating said solvent so as to generate said calcium carbonate particles that are at least partially coated with said alkali metal fluoride.

9. The combination tooth cleaning and remineralization method of claim 1, wherein said remineralization results in increased density and/or thickness of an enamel layer on said tooth.

Description

BRIEF DESCRIPTION OF THE FIGURES

(1) FIG. 1A is an image of demineralized bovine enamel before treatment with calcium carbonate in accordance with Example 2 (Group 1).

(2) FIG. 1B is an image of the demineralized bovine enamel of FIG. 1A after treatment with calcium carbonate in accordance with Example 2 (Group 1).

(3) FIG. 2A is an image of demineralized bovine enamel before treatment with sodium bicarbonate in accordance with Example 2 (Group 2).

(4) FIG. 2B is an image of the demineralized bovine enamel of FIG. 2A after treatment with sodium bicarbonate in accordance with Example 2 (Group 2).

(5) FIG. 3A is an image of demineralized bovine enamel with distinct structures before treatment with calcium carbonate particles coated with sodium fluoride 1 in accordance with Example 2 (Group 3).

(6) FIG. 3B is an image of the demineralized bovine enamel of FIG. 3A after treatment with calcium carbonate particles coated with sodium fluoride 1 in accordance with Example 2 (Group 3). It can be seen that bridges of precipitate start filling the gaps between the enamel structures.

(7) FIG. 4A is an image of demineralized bovine enamel before treatment with calcium carbonate particles spray coated with 1 wt. % of sodium fluoride and 10 wt. % of xylitol in accordance with Example 2 (Group 4).

(8) FIG. 4B is an image of the demineralized bovine enamel of FIG. 4A after treatment with calcium carbonate particles spray coated with 1 wt. % of sodium fluoride and 10 wt. % of xylitol in accordance with Example 2 (Group 4). The remineralization process is most evident. As can be seen in FIG. 4B, the treated enamel surfaces showed a build up of a uniform layer of precipitate, covering in most part the enamel structure.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

(9) It was surprisingly found that the desired effect on the remineralization of tooth is not attained if calcium carbonate particles are only mixed with particles of the alkali metal fluoride. Only if the calcium carbonate particles are coated with the alkali metal fluoride the thus obtained particles help remineralization. While applicants do not wish to be bound to any theory it is believed that when the powder hits the tooth surface, it is in a slurry of water and the fluoride ion gets released immediately. A critical feature of the product to help remineralization is the speed of release. If this release is too slow, the calcium ions are already washed away and are thus no longer available for remineralization. Because of the coating of the calcium carbonate particles with the alkali metal fluoride, the fluoride ions get released into the patient's mouth immediately thereby facilitating remineralization of the tooth.

(10) The alkali metal fluoride may preferably be selected from potassium fluoride and sodium fluoride. Most preferably the alkali metal fluoride is sodium fluoride.

(11) The coating of the calcium carbonate particles with the alkali metal fluoride can be conducted by any suitable method known in the art. For example the calcium carbonate particles can be sprayed with a solution of the alkali metal fluoride. By evaporation of the solvent the alkali metal fluoride is deposited on the surface of the calcium carbonate particles forming the coating.

(12) The size of the calcium carbonate particles is not particularly limited as long as they are suitable for the powder blasting of tooth surfaces. For example, the calcium carbonate particles may have a mean particle size in the range of about 10 m to about 200 m, preferably in the range of about 40 m to about 100 m, most preferably in the range of about 60 m to about 70 m, such as about 65 m. The mean size of the particles is for example measured using the LS 13 320 Laser Diffraction Particle Size Analyzer available through Beckman Coulter, Inc. (Brea, Calif.).

(13) In a preferred embodiment of the present invention the calcium carbonate particles have a narrow particle size distribution. Also preferred are calcium carbonate particles being substantially spherical.

(14) The amount of alkali metal fluoride with which the calcium carbonate particles are coated can for example be in the range of about 1,000 ppm to about 20,000 ppm relative to the weight of the uncoated particles. Preferably, the calcium carbonate particles comprise an amount of alkali metal fluoride of about 1,000 ppm, about 1,500 ppm or about 12,300 ppm, each relative to the weight of the uncoated particles.

(15) In further embodiments the present invention provides the use of calcium carbonate particles being at least partially coated with an alditol or being mixed with particles of at least one alditol for dental powder blasting. It has surprisingly been found that the presence of the alditol also facilitates the remineralization effect of the calcium carbonate particles.

(16) In one embodiment the calcium carbonate particles used in one of the above described combinations with an alditol are those calcium carbonate particles being at least partially coated with an alkali metal fluoride as described above. In particular the particles have the same preferred features with respect to the alkali metal fluoride, the amount of the fluoride and their particle size as described above. The calcium carbonate particles being at least partially coated with the alkali metal fluoride may either be mixed with the particles of at least one alditol or they may be additionally at least partially be coated with the alditol. If the calcium carbonate particles are not coated with an alkali metal fluoride, they have nevertheless the above described preferred features with respect to for example particle size and particle size distribution.

(17) As alditol for example mannitol, erythritol, xylitol and sorbitol are suitable. Xylitol is most preferred.

(18) The mean size of the alditol particles should be selected such that it fits to the mean size of the calcium carbonate particles in that the mixture of the particles is physically stable, i.e. none of the particles separates from the mixture. Thus, the alditol particles suitably have a mean particle size in the range of about 10 m to about 200 m, preferably in the range of about 40 m to about 100 m, most preferably in the range of about 53 m to about 88 m. The mean particle size of the alditol particles is measured like the mean particle size of the calcium carbonate particles described above.

(19) The amount of alditol added to the calcium carbonate particles either as coating or in a mixture is not particularly limited and can be selected by the skilled person according to the requirements. For example, the powder mixture can comprise from about 1 wt. % to about 20 wt. % of alditol, preferably from about 5 wt. % to about 15 wt. % of alditol, most preferably from about 7 wt. % to about 13 wt. % of alditol, each based on the total weight of the powder.

(20) In a different embodiment of the present invention where the calcium carbonate particles are mixed with particles of at least one alditol the amount of alditol in the powder mixture may be higher, such as from about 50 wt. % to about 98 wt. %, preferably from about 70 wt. % to about 98 wt. %, more preferably from about 85 wt. % to about 95 wt. % of alditol particles, each based on the total weight of the powder.

(21) It is suitable that the powder or powder mixture to be used for the dental powder blasting according to the invention substantially entirely or even entirely consists of the above described ingredients. Preferably the powder contains a maximum of about 20 wt. %, more preferably a maximum of about 10 wt. % and most preferably a maximum of about 2 wt. % of particles other than the calcium carbonate particles and the alditol particles, each based on the total weight of the powder. For example the powder may contain about 2 wt. % of silicone dioxide powder.

(22) The above described calcium carbonate particles and the above described powder mixtures have the advantage of being not only suitable as cleaning powders abrasively removing some enamel during the cleaning process but they will clean and remineralize the tooth at the same time thereby protecting or even improving the enamel layer.

(23) The present invention further relates to calcium carbonate particles being at least partially coated with an alkali metal fluoride and an alditol. A further embodiment relates to calcium carbonate particles being at least partially coated with an alditol. In a further embodiment the invention relates to a powder mixture comprising a) calcium carbonate particles being at least partially coated with an alkali metal fluoride and b) particles of at least one alditol. Furthermore, the invention relates to a dry powder mixture comprising calcium carbonate particles and particles of at least one alditol. In these embodiments the calcium carbonate particles and the particles of at least one alditol have the same preferred features as described above with respect to the use of these particles and powder mixtures in dental powder blasting.

(24) In the context of the present application the dry powder mixture is defined as a powder mixture which does not contain any water or other liquid (such as an oil) in addition to the moisture which is naturally present in the powder being in contact with the surrounding air.

(25) Thus, the dry powder mixture of the present invention may still contain the amount of water which is present in equilibrium with the humidity of the surrounding air.

(26) In a preferred embodiment the dry powder mixture of the present invention is free flowing. In particular, the dry powder mixture is not a paste like a tooth paste.

(27) Finally, the present invention relates to a tooth cleaning method comprising the steps of: providing calcium carbonate particles as described above or a powder mixture as described above; and powder blasting a tooth surface with said particles or powder mixture.

(28) In the method of the present invention, the particles or powder mixture are preferably mixed with air and water and the resulting mixture is applied onto the tooth surface to be treated by a powder-jet device that mixes the particles or powder mixture with air to form a powder/air mixture and blasts said powder/air mixture together with said water onto said tooth surface.

(29) The present invention will now be explained in more detail by way of example, which is not intended to be construed as limiting.

EXAMPLES

Example 1

(30) Calcium carbonate particles having a mean particle size of about 65 m were coated with 1,500 ppm and 12,300 ppm sodium fluoride, respectively.

(31) The thus obtained coated calcium carbonate particles were either used alone or in admixture with about 2 wt. % to about 6 wt. % of xylitol particles having a mean particle size in the range of 53 m to 88 m for powder blasting of tooth with a powder-jet device. Alternatively, the uncoated calcium carbonate particles were used in admixture with about 2 wt. % to about 6 wt. % of the xylitol particles.

(32) By using the coated calcium carbonate particles alone or in admixture with the xylitol particles or by using the uncoated calcium carbonate particles in admixture with the xylitol particles the tooth was not only cleaned but at the same time remineralized.

Example 2

(33) 12 bovine teeth were divided in four groups of three. From each tooth, 4 surfaces of 22 mm were isolated from the buccal tooth surface. One surface of each tooth was held in artificial saliva and used as control. All remaining surfaces were etched using phosphoric acid gel.

(34) The four groups of tooth surfaces were treated as follows:

(35) Group 1: The enamel surfaces were immersed in 20 ml of artificial saliva containing 10% granulated Calcium Carbonate, for 24 hours.

(36) Group 2: The enamel surfaces were immersed in 20 ml of artificial saliva containing 10% Air Flow Classic (Sodium Bicarbonate), for 24 hours.

(37) Group 3: The enamel surfaces were immersed in 20 ml of artificial saliva containing 10% engineered Calcium Carbonate particles (Calcium Carbonate particles coated with Sodium Fluoride 1 wt. %), for 24 hours.

(38) Group 4: The enamel surfaces were immersed in 20 ml of artificial saliva containing 10% engineered Calcium Carbonate particles (Calcium Carbonate particles coated with Sodium Fluoride 1 wt. % and Xylitol 10 wt. %), for 24 hours.

(39) All samples were analyzed using SEM.

(40) Groups 1 and 2 are comparative examples conducted with calcium carbonate and sodium bicarbonate, respectively, as used in the prior art for dental powder blasting. Images of the enamel surfaces before and after treatment are presented in FIGS. 1A and 1B (Group 1) and 2A and 2B (Group 2). Both treatments show no remineralization. The fish scale structures of the enamel can still be seen, remineralization bridges were not observed.

(41) Groups 3 and 4 are according to the invention using calcium carbonate particles coated with 1 wt. % of sodium fluoride in Group 3 and additionally with 10 wt. % of xylitol in Group 4. Images of the enamel surfaces before and after treatment are presented in FIGS. 3A and 3B (Group 3) and 4 (Group 4).

Example 3

(42) Six human molars were scanned before and after demineralization with phosphoric acid, using a Canary Lab System (Quantum Dental Technologies).

(43) The six molars were then treated as follows:

(44) Molar 1 was immersed in 20 ml of artificial saliva containing 10% granulated Calcium Carbonate suspension, for 6 hours.

(45) Molar 2 was immersed in 20 ml of artificial saliva containing 10% Air Flow Perio (Glycine), for 6 hours.

(46) Molar 3 was immersed in 20 ml of artificial saliva containing 10% engineered Calcium Carbonate particles (Calcium Carbonate particles coated with Xylitol, 10 wt. %) for 6 hours.

(47) Molar 4 was immersed in 20 ml of artificial saliva containing 10% engineered Calcium Carbonate particles (Calcium Carbonate particles coated with Sodium Fluoride 1 wt. %), for 6 hours.

(48) Molar 5 was immersed in 20 ml of artificial saliva containing 10% engineered Calcium Carbonate particles (Calcium Carbonate particles coated with Sodium Fluoride 1 wt. % and Xylitol 10 wt. %), for 6 hours.

(49) Molar 6 was immersed in 20 ml of artificial saliva containing 10% of a mixture of 88 wt. % Xylitol, 10 wt. % Calcium Carbonate granules, and 2 wt. % Silicon Dioxide, for 6 hours.

(50) During the experiment, all samples were stored in 50 ml tubes, suspended in the solution using nylon line (to avoid direct contact with the precipitate) and maintained at 37 C. using a water bath.

(51) The Canary Lab System measurements consisted on scanning a 22 mm area. The results of the measurements were reported in Canary Number and PTR Amplitude number. A decrease in the Canary Number represents an increase in the density of the enamel layer. A decrease in PTR Amplitude values represents an increase of thickness of the enamel layer.

(52) The results are summarized in Tables 1 and 2 below.

(53) TABLE-US-00001 TABLE 1 Canary Canary change improvement Number Number in vs. before after Canary comparative Experiment treatment treatment Number Molar 1 Molar 1 17.50 21.73 +24% / (comparative) Molar 2 18.09 22.62 +25% / (comparative) Molar 3 13.95 16.28 +16% 8% (invention) Molar 4 21.12 18.45 14% 38% (invention) Molar 5 19.40 16.55 13% 37% (invention) Molar 6 17.58 20.59 +17% 7% (invention

(54) TABLE-US-00002 TABLE 2 PTR PTR change improvement Amplitude Amplitude in vs. before after PTR comparative Experiment treatment treatment Amplitude Molar 1 Molar 1 76.9 106.0 +38% / (comparative) Molar 2 77.6 101.4 +31% / (comparative) Molar 3 67.8 66.0 3% 41% (invention) Molar 4 114.6 116.0 1% 39% (invention) Molar 5 95.1 77.2 19% 57% (invention) Molar 6 96.4 88.7 8% 46% (invention

(55) The data in the above Tables 1 and 2 confirm that treatment of human molar with the dental blasting powders according to the invention results in a significant decrease in the Canary Number and PTR Amplitude compared to the treatment with prior art blasting powders, in particular calcium carbonate. The decreases in Canary Number and PTR Amplitude demonstrate significant increases in density and thickness of the enamel layers.