LANTIBIOTIC SOLUTION AGAINST BACTERIAL INFECTIONS

Abstract

A lantibiotic solution against bacterial infections comprises an aqueous solvent, a water-soluble polymeric component, class I bacteriocins, and amphipathic molecules.

Claims

1. A lantibiotic solution against bacterial infections, wherein it comprises an aqueous solvent, a water-soluble polymeric component, class I bacteriocins, and hydroxytyrosol.

2. The lantibiotic solution according to claim 1, wherein the concentration of the polymeric component is between 1 and 30% by weight.

3. The solution according to claim 1, wherein the concentration of the class I bacteriocins is between 1 and 10 mM.

4. The solution according to claim 1, wherein the concentration of hydroxytyrosol is less than or equal to 100 mM.

5. The solution according to claim 1, wherein the class I bacteriocins are selected from a group comprising Nisin Z, Nisin A and/or Nisin F.

6. The solution according to claim 1, wherein the water-soluble polymeric component is selected from a group comprising a polymer and/or polymeric mixtures and/or copolymers of ethylene oxide (PEG, PEO, POE), vinyl alcohol, vinyl pyrrolidone, lactic acid.

Description

PREFERRED EMBODIMENTS OF THE INVENTION

[0025] A lantibiotic solution against bacterial infections comprises an aqueous solvent, a water-soluble polymeric component, class I bacteriocins, and hydroxytyrosol. The mixing in millimolar concentrations of the bacteriocins with hydroxytyrosol allows the prevention and treatment of bacterial infections and/or prevention of the formation of biofilms at surgical operation sites (for example, in the implant of prosthetic devices) and in infected periodontal or peri-implant pockets; and also speeds up healing of the extracellular matrix of the tissues. The class I bacteriocins, also called lantibiotics because they contain modified amino acids of the lanthionine type, are capable, aided by the antioxidant and solubilizing action of the hydroxytyrosol, both of forming pores on the membranes of the bacteria, both Gram positive and Gram negative, causing their cell death and thereby eradicating the cause of possible infections, and, at the same time, of activating the cells of the surrounding tissue to rebuild the damaged extracellular matrix.

[0026] In the aqueous solution, the concentration of the polymeric component is between 1 and 30% by weight. The concentration of the class I bacteriocins is between 1 and 10 mM, whilst the concentration of hydroxytyrosol is less than or equal to 100 mM.

[0027] The class I bacteriocins are selected from a group comprising Nisin Z, Nisin A and/or Nisin F, whilst the water-soluble polymeric component is preferably selected from a group comprising a polymer and/or polymeric mixtures and/or copolymers of ethylene oxide (PEG, PEO, POE), vinyl alcohol, vinyl pyrrolidone, lactic acid.