OCULAR EYELID SCRUB COMPOSITION FOR THE TREATMENT OF DEMODEX BLEPHARITIS

Abstract

A composition for the treatment of Demodex blepharitis containing tea tree oil and/or Neem oil and coconut oil in glycerol or in water or in a mixture of glycerol and water. The composition may further contain aloe barbadensis gel, sodium lauryl sulfate, cocoamidopropyl betaine, lauroyl glucoside, or DMDM hydantoin, or a combination thereof', in glycerol or in water or in a mixture of glycerol and water. The composition is used to treat Demodex blepharitis by applying the composition to the eyelid margin and eyelashes and scrubbing the eyelid margin, eyelashes, and eyelash roots with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

Claims

1. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO) and aloe barbadensis in glycerol or in water or in a mixture of glycerol and water.

2. The composition of claim 1 further comprising cocoamidopropyl betaine.

3. The composition of claim 1 further comprising Neem oil.

4. The composition of claim 1 further comprising coconut oil.

5. A composition for the treatment of Demodex blepharitis, comprising: coconut oil and aloe barbadensis in glycerol or in water or in a mixture of glycerol and water.

6. The composition of claim 5 further comprising cocoamidopropyl betaine. The composition of claim 5 further comprising Neem oil.

8. The composition of claim 5 further comprising tea tree oil (TTO).

9. A composition for the treatment of Demodex blepharitis, comprising: Neem oil and aloe barbadensis in glycerol or in water or in a mixture of glycerol and water.

10. The composition of claim 9 further comprising cocoamidopropyl betaine.

11. The composition of claim 9 further comprising coconut oil.

12. The composition of claim 9 further comprising tea tree oil (TTO).

13. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO); Neem oil; coconut oil; and aloe barbadensis in glycerol or in water or in a mixture of glycerol and water.

14. The composition of claim 13 further comprising cocoamidopropyl betaine.

15. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO); Neem oil; and cocoamidopropyl betaine in glycerol or in water or in a mixture of glycerol and water.

16. The composition of claim 15 further comprising aloe barbadensis.

Description

EXAMPLE 1

[0013] 1 ml of TTO and 3 ml of coconut oil are added to 80 ml of glycerol and 16 ml of water to provide 1% v/v TTO and 3% coconut oil v/v in a mixture of glycerol 80% v/v and water 16% v/v.

EXAMPLE 2

[0014] 10 ml of Neem oil and 3 ml of coconut oil are added to 70 ml of glycerol and 17 ml of water to provide 10% v/v Neem oil and 3% coconut oil v/v in a mixture of glycerol 70% v/v and water 13%.

EXAMPLE 3

[0015] 1 ml of TTO, 10 ml of Neem oil; and 3 ml of coconut oil are added to 69 ml of glycerol and 17 ml of water to provide 1% v/v TTO, 10% v/v Neem oil, 3% v/v coconut oil in a mixture of glycerol 69% v/v and water 17% v/v.

EXAMPLE 4

[0016] 1% v/v TTO and 3% coconut oil v/v are combined with aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl Maine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or water or any desired mixture of glycerol and water.

EXAMPLE 5

[0017] 10% v/v Neem oil and 3% coconut oil v/v are combined with aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl betaine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or water or any desired mixture of glycerol and water.

EXAMPLE 6

[0018] 1% v/v TTO, 10% v/v Neem oil, and 3% v/v coconut oil in a mixture of glycerol 69% v/v and water 17% v/v are combined with aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl betaine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or water or any desired mixture of glycerol and water.

[0019] Formulations and compositions of TTO and/or Neem oil and coconut oil can be used in combination with cleaning towels or cotton tipped applicators for application of the formulation to the eyelid. The formulations and compositions can also be prepared in a foam dispensing bottle having a pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, or a gelling agent, or a combination thereof, and a propellant.

[0020] The formulations and compositions of TTO and/or Neem oil and coconut oil provide a method of treating an ocular Demodex-induced blepharitis in the eyelid. The method includes administering to the eyelid a therapeutically-effective amount of a composition having TTO or Neem oil, or a combination thereof, and coconut oil as active agents. The composition is administered topically to the eyelid margin and eyelashes by means of a cleaning towel, a cotton tip applicator, or a foam composition, or a combination thereof. The eyelid margin, eyelashes, and eyelash roots are scrubbed with the composition.

EXAMPLE 7

[0021] A composition having TTO or Neem oil, or a combination thereof, and coconut oil as active agents is provided to a person having Demodex-induced blepharitis in the eyelid. The composition is applied to the eyelid margin and eyelashes. The eyelid margin, eyelashes, and eyelash roots are scrubbed with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

[0022] While this invention has been described in some detail with reference to specific exemplary embodiments, there is no intention that the invention be limited to such detail. On the contrary, the invention is intended to include any alternative or equivalent embodiments that fall within the spirit and scope of the invention as described and claimed herein.