Topical drug for treating breast cancer and preparation method thereof

Abstract

Disclosed is a topical drug for treating breast cancer and preparation method thereof. The topical drug comprises the following ingredients in parts by weight: 5-10 parts of Astragalus, 3-5 parts of Oldenlandia diffusa, 3-5 parts of dandelion, 5-10 parts of Lycoris radiate, 5-8 parts of Carapax trionycis, 3-5 parts of Pinellia pedatisecta, 2-3 parts of Acorus calamus, 3-5 parts of Ferula sinkiangensis, 3-5 parts of doubleteeth pubescent angelica root, 4-6 parts of Cryptotaenia japonica Hassk, 3-5 parts of Whitmania pigra Whitman, 5-8 parts of Wedelia chinensis, 6-8 parts of Echinacea purpurea, 4-6 parts of Folium Eriobotryae, 3-5 parts of Sedum sarmentosum, 5-10 parts of Angelicae sinensis, 2-5 parts of asparagus, 2-3 parts of scorpio, 5-8 parts of Rubia cordifolia L., 2-3 parts of alfalfa extract, 3-5 parts of extract of Jew's ear from mulberry trees, 5-7 parts of myrrh, 3-6 parts of nutgrass galingale rhizome and 3-5 parts of pericarpium citri reticulatae viride.

Claims

1. A topical drug for treating breast cancer, wherein, the said topical drug for treating breast cancer comprises the following components in parts by weight: 5-10 parts of Astragalus, 3-5 parts of Oldenlandia diffusa, 3-5 parts of dandelion, 5-10 parts of Lycoris radiate, 5-8 parts of Carapax trionycis, 3-5 parts of Pinellia pedatisecta, 2-3 parts of Acorus calamus, 3-5 parts of Ferula sinkiangensis, 3-5 parts of doubleteeth pubescent angelica root, 4-6 parts of Cryptotaenia japonica Hassk, 3-5 parts of Whitmania pigra Whitman, 5-8 parts of Wedelia chinensis, 6-8 parts of Echinacea purpurea, 4-6 parts of Folium Eriobotryae, 3-5 parts of Sedum sarmentosum, 5-10 parts of Angelicae sinensis, 2-5 parts of asparagus, 2-3 parts of scorpio, 5-8 parts of Rubia cordifolia L., 2-3 parts of alfalfa extract, 3-5 parts of extract of Jew's ear from mulberry trees, 5-7 parts of myrrh, 3-6 parts of nutgrass galingale rhizome and 3-5 parts of pericarpium citri reticulatae viride.

2. The topical drug for treating breast cancer according to claim 1, wherein, the said topical drug for treating breast cancer comprises the following components in parts by weight: 8 parts of Astragalus, 4 parts of Oldenlandia diffusa, 4 parts of dandelion, 7 parts of Lycoris radiate, 6 parts of Carapax trionycis, 4 parts of Pinellia pedatisecta, 2.5 parts of Acorus calamus, 4 parts of Ferula sinkiangensis, 4 parts of doubleteeth pubescent angelica root, 5 parts of Cryptotaenia japonica Hassk, 4 parts of Whitmania pigra Whitman, 6 parts of Wedelia chinensis, 7 parts of Echinacea purpurea, 5 parts of Folium Eriobotryae, 4 parts of Sedum sarmentosum, 8 parts of Angelicae sinensis, 3 parts of asparagus, 2 parts of scorpio, 7 parts of Rubia cordifolia L., 2 parts of alfalfa extract, 4 parts of extract of Jew's ear from mulberry trees, 6 parts of myrrh, 5 parts of nutgrass galingale rhizome and 5 parts of pericarpium citri reticulatae viride.

3. The topical drug for treating breast cancer according to claim 1, wherein, the said topical drug for treating breast cancer comprises the following auxiliary materials in parts by weight: 100-110 parts of water, 4-5 parts of glycerin, 1-1.5 parts of xanthan gum, 1-1.5 parts of vegetable oil, 1-2 parts of squalene, 5-6 parts of emulsifier, 0.5-1 parts of polysorbate-20, 0.5-1 parts of triethanolamine, 0.5-1 parts of panthenol, 0.1-0.5 parts of thymopentin and 2-3 parts of honey.

4. A method for preparation of the topical drug for treating breast cancer, wherein, it comprises the following steps: (1) weighing the following components in parts by weight: 5-10 parts of Astragalus, 3-5 parts of Oldenlandia diffusa, 3-5 parts of dandelion, 5-10 parts of Lycoris radiate, 5-8 parts of Carapax trionycis, 3-5 parts of Pinellia pedatisecta, 2-3 parts of Acorus calamus, 3-5 parts of Ferula sinkiangensis, 3-5 parts of doubleteeth pubescent angelica root, 5-6 parts of Cryptotaenia japonica Hassk, 3-5 parts of Whitmania pigra Whitman, 5-8 parts of Wedelia chinensis, 6-8 parts of Echinacea purpurea, 4-6 parts of Folium Eriobotryae, 3-5 parts of Sedum sarmentosum, 5-10 parts of Angelicae sinensis, 2-5 parts of asparagus, 2-3 parts of scorpio, 5-8 parts of Rubia cordifolia L., 5-7 parts of myrrh, 3-6 parts of nutgrass galingale rhizome and 3-5 parts of pericarpium citri reticulatae viride; adding water to the mixture of those components, in which the weight of water is 4-5 times the weight of all the above-mentioned components; decocting the mixture for 100-150 minutes; then filtering the mixture to get the filtrate and dregs for later use; (2) adding ethanol solution to the dregs obtained by step (1), in which the weight of ethanol solution is 4-5 times the weight of the dregs; decocting the mixture for 120-160 minutes; then filtering it to get the filtrate and dregs for later use; (3) heating the filtrate obtained by step (2) to 80-90 C.; and recovering the ethanol and getting the filtrate; (4) adding acetic acid solution to the dregs obtained by step (2), in which the weight of acetic acid solution is 4-5 times the weight of the dregs; decocting the mixture for 50-70 minutes; then filtering it to get the filtrate; (5) combining the filtrate obtained by step (1), step (3) and step (4); then adding 2-3 parts by weight of alfalfa extract and 3-5 parts by weight of extract of Jew's ear from mulberry trees to the combined filtrate; heating and stirring the mixed solution at 40-50 C. until its weight is 1.5-2 times the weight of all herbs; (6) weighing 100-110 parts by weight of water, 4-5 parts by weight of glycerin and 1-1.5 parts by weight of xanthan gum; dissolving and mixing them together; heating the mixed solution to 80 C.; and sterilizing it; (7) weighing 1-1.5 parts by weight of vegetable oil, 1-2 parts by weight of squalene, 5-6 parts by weight of emulsifier, 0.5-1 parts by weight of polysorbate-20, 0.5-1 parts by weight of triethanolamine and 0.5-1 parts by weight of panthenol; mixing them; then heating the mixed solution to 80 C.; (8) mixing the solution obtained by step (6) and step (7) and stirring evenly; when the mixture being cooled to 40-50 C., adding 2-3 parts by weight of honey and stirring evenly; then keeping the mixed solution at the current temperature for 20-25 minutes; (9) mixing the solution obtained by step (5) and step (8); then keeping stirring the mixture until its temperature falls to room temperature; and (10) standing the solution obtained by step (9), then testing and filling to obtain the finished product.

5. The method for preparation of the topical drug for treating breast cancer according to claim 4, wherein, in step (1), the mixture is soaked at room temperature for 20-25 minutes after adding 4-5 times water to it; then the mixture is decocted at 80-90 C. for 100-150 minutes.

6. The method for preparation of the topical drug for treating breast cancer according to claim 4, wherein, in step (2), the concentration of the ethanol solution is 50-60% and the decocting temperature is 60-70 C.

7. The method for preparation of the topical drug for treating breast cancer according to claim 4, wherein, in step (4), the concentration of the acetic acid solution is 15-18% and the decocting temperature is 40-50 C.

8. The method for preparation of the topical drug for treating breast cancer according to claim 4, wherein, in step (5), the temperature of the filtrate obtained by step (1) and step (3) is reduced down to room temperature; then the above filtrate is combined with the filtrate obtained by step (4).

9. The method for preparation of the topical drug for treating breast cancer according to claim 4, wherein, the solution obtained by step (5) is treated with small molecule cutting technology to retain its activity and effectiveness simultaneously.

Description

MODE OF CARRYING OUT THE INVENTION

Example 1

(1) A topical drug for treating breast cancer comprises the following components in parts by weight:

(2) 5 parts of Astragalus, 3 parts of Oldenlandia diffusa, 3 parts of dandelion, 5 parts of Lycoris radiate, 5 parts of Carapax trionycis, 3 parts of Pinellia pedatisecta, 2 parts of Acorus calamus, 3 parts of Ferula sinkiangensis, 3 parts of doubleteeth pubescent angelica root, 4 parts of Cryptotaenia japonica Hassk, 3 parts of Whitmania pigra Whitman, 5 parts of Wedelia chinensis, 6 parts of Echinacea purpurea, 4 parts of Folium Eriobotryae, 3 parts of Sedum sarmentosum, 5 parts of Angelicae sinensis, 2 parts of asparagus, 2 parts of scorpio, 5 parts of Rubia cordifolia L., 2 parts of alfalfa extract, 3 parts of extract of Jew's ear from mulberry trees, 5 parts of myrrh, 3 parts of nutgrass galingale rhizome, 3 parts of pericarpium citri reticulatae viride;

(3) auxiliary materials: 100-110 parts of water, 4-5 parts of glycerin, 1-1.5 parts of xanthan gum, 1-1.5 parts of vegetable oil, 1-2 parts of squalene, 5-6 parts of emulsifier, 0.5-1 parts of polysorbate-20, 0.5-1 parts of triethanolamine, 0.5-1 parts of panthenol, 0.1-0.5 parts of thymopenti and 2-3 parts of honey.

(4) The following preparation is carried out according to the above-mentioned ratio of the topical drug for treating breast cancer, comprising the following steps:

(5) (1) mixing Astragalus, Oldenlandia diffusa, dandelion, Lycoris radiate, Carapax trionycis, Pinellia pedatisecta, Acorus calamus, Ferula sinkiangensis, doubleteeth pubescent angelica root, Cryptotaenia japonica Hassk, Whitmania pigra Whitman, Wedelia chinensis, Echinacea purpurea, Folium Eriobotryae, Sedum sarmentosum, Angelicae sinensis, asparagus, scorpio, Rubia cordifolia L., myrrh, nutgrass galingale rhizome and pericarpium citri reticulatae viride together; adding water into the mixture of those components, in which the weight of the water is 4-5 times the weight of all the mixture; after soaking the mixture at room temperature for 20-25 minutes, decocting it at 80-90 C. for 100-150 minutes; then filtering it to get the filtrate and dregs for later use;

(6) (2) adding 50-60% ethanol solution to the dregs obtained by step (1), in which the weight of the ethanol solution is 4-5 times the weight of the dregs; decocting the mixture at 60-70 C. for 120-160 minutes; then filtering it to get the filtrate and dregs for later use;

(7) (3) heating the filtrate obtained by step (2) to 80-90 C.; and recovering the ethanol and getting the filtrate;

(8) (4) adding 15-18% acetic acid solution to the dregs obtained by step (2), in which the weight of the acetic acid solution is 4-5 times the weight of the dregs; decocting the mixture at 40-50 C. for 50-70 minutes; then filtering it to get the filtrate;

(9) (5) letting the temperature of the filtrate obtained by step (1) and step (3) down to 40-50 C., then mixing them with the filtrate obtained by step (4); adding alfalfa extract and extract of Jew's ear from mulberry trees to the combined filtrate; heating and stirring the mixed solution at 40-50 C. until its weight is 1.5-2 times the weight of all herbs; and treating the mixed solution with small molecule cutting technology to retain its activity and effectiveness;

(10) (6) weighing 100-110 parts by weight of water, 4-5 parts by weight of glycerin and 1-1.5 parts by weight of xanthan gum; dissolving and mixing them together; heating the mixed solution to 80 C.; and sterilizing it;

(11) (7) weighing 1-1.5 parts by weight of vegetable oil, 1-2 parts by weight of squalene, 5-6 parts by weight of emulsifier, 0.5-1 parts by weight of polysorbate-20, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of panthenol and 0.1-0.5 parts by weight of thymopentin; mixing them; then heating the mixed solution to 80 C.;

(12) (8) mixing the solution obtained by step (6) and step (7) and stirring evenly; when the mixture being cooled to 40-50 C., adding 2-3 parts by weight of honey and stirring evenly; then keeping the mixed solution at the current temperature for 20-25 minutes;

(13) (9) mixing the solution obtained by step (5) and step (8); then keeping stirring the mixture until its temperature falls to room temperature; and

(14) (10) standing the mixture obtained by step (9), then testing and filling to obtain the finished product.

Example 2

(15) A topical drug for treating breast cancer comprises the following components in parts by weight:

(16) 8 parts of Astragalus, 4 parts of Oldenlandia diffusa, 4 parts of dandelion, 7 parts of Lycoris radiate, 6 parts of Carapax trionycis, 4 parts of Pinellia pedatisecta, 2.5 parts of Acorus calamus, 4 parts of Ferula sinkiangensis, 4 parts of doubleteeth pubescent angelica root, 5 parts of Cryptotaenia japonica Hassk, 4 parts of Whitmania pigra Whitman, 6 parts of Wedelia chinensis, 7 parts of Echinacea purpurea, 5 parts of Folium Eriobotryae, 4 parts of Sedum sarmentosum, 8 parts of Angelicae sinensis, 3 parts of asparagus, 2 parts of scorpio, 7 parts of Rubia cordifolia L., 2 parts of alfalfa extract, 4 parts of extract of Jew's ear from mulberry trees, 6 parts of myrrh, 5 parts of nutgrass galingale rhizome and 5 parts of pericarpium citri reticulatae viride;

(17) auxiliary materials: 100-110 parts of water, 4-5 parts of glycerin, 1-1.5 parts of xanthan gum, 1-1.5 parts of vegetable oil, 1-2 parts of squalene, 5-6 parts of emulsifier, 0.5-1 parts of polysorbate-20, 0.5-1 parts of triethanolamine, 0.5-1 parts of panthenol, 0.1-0.5 parts of thymopenti and 2-3 parts of honey.

(18) The following preparation is carried out according to the above-mentioned ratio of the topical drug for treating breast cancer, comprising the following steps:

(19) (1) mixing Astragalus, Oldenlandia diffusa, dandelion, Lycoris radiate, Carapax trionycis, Pinellia pedatisecta, Acorus calamus, Ferula sinkiangensis, doubleteeth pubescent angelica root, Cryptotaenia japonica Hassk, Whitmania pigra Whitman, Wedelia chinensis, Echinacea purpurea, Folium Eriobotryae, Sedum sarmentosum, Angelicae sinensis, asparagus, scorpio, Rubia cordifolia L., myrrh, nutgrass galingale rhizome and pericarpium citri reticulatae viride together; adding water into the mixture of those components, in which the weight of the water is 4-5 times the weight of all the mixture; after soaking the mixture at room temperature for 20-25 minutes, decocting it at 80-90 C. for 100-150 minutes; then filtering it to get the filtrate and dregs for later use;

(20) (2) adding 50-60% ethanol solution to the dregs obtained by step (1), in which the weight of the ethanol solution is 4-5 times the weight of the dregs; decocting the mixture at 60-70 C. for 120-160 minutes; then filtering it to get the filtrate and dregs for later use;

(21) (3) heating the filtrate obtained by step (2) to 80-90 C.; and recovering the ethanol and get the filtrate;

(22) (4) adding 15-18% acetic acid solution to the dregs obtained by step (2), in which the weight of acetic acid solution is 4-5 times the weight of the dregs; decocting the mixture at 40-50 C. for 50-70 minutes; then filtering it to get the filtrate;

(23) (5) letting the temperature of the filtrate obtained by step (1) and step (3) down to 40-50 C., then mixing them with the filtrate obtained by step (4); adding alfalfa extract and extract of Jew's ear from mulberry trees to the combined filtrate; heating and stirring the mixed solution at 40-50 C. until its weight is 1.5-2 times the weight of all herbs; and treating the mixed solution with small molecule cutting technology to retain its activity and effectiveness;

(24) (6) weighing 100-110 parts by weight of water, 4-5 parts by weight of glycerin and 1-1.5 parts by weight of xanthan gum; dissolving and mixing them together; heating the mixed solution to 80 C.; and sterilizing it;

(25) (7) weighing 1-1.5 parts by weight of vegetable oil, 1-2 parts by weight of squalene, 5-6 parts by weight of emulsifier, 0.5-1 parts by weight of polysorbate-20, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of panthenol and 0.1-0.5 parts by weight of thymopentin; mixing them; then heating the mixed solution to 80 C.;

(26) (8) mixing the solution obtained by step (6) and step (7) and stirring evenly; when the mixture being cooled to 40-50 C., adding 2-3 parts by weight of honey and stir ring evenly; then keeping the mixed solution at the current temperature for 20-25 minutes;

(27) (9) mixing the solution obtained by step (5) and step (8); then keeping stirring the mixture until its temperature falls to room temperature; and

(28) (10) standing the mixture obtained by step (9), then testing and filling to obtain the finished product.

Example 3

(29) A topical drug for treating breast cancer comprises the following components in parts by weight:

(30) 10 parts of Astragalus, 5 parts of Oldenlandia diffusa, 5 parts of dandelion, 10 parts of Lycoris radiate, 8 parts of Carapax trionycis, 5 parts of Pinellia pedatisecta, 3 parts of Acorus calamus, 5 parts of Ferula sinkiangensis, 5 parts of doubleteeth pubescent angelica root, 6 parts of Cryptotaenia japonica Hassk, 5 parts of Whitmania pigra Whitman, 8 parts of Wedelia chinensis, 8 parts of Echinacea purpurea, 6 parts of Folium Eriobotryae, 5 parts of Sedum sarmentosum, 10 parts of Angelicae sinensis, 5 parts of asparagus, 3 parts of scorpio, 8 parts of Rubia cordifolia L., 3 parts of alfalfa extract, 5 parts of extract of Jew's ear from mulberry trees, 7 parts of myrrh, 6 parts of nutgrass galingale rhizome, 5 parts of pericarpium citri reticulatae viride;

(31) auxiliary materials: 100-110 parts of water, 4-5 parts of glycerin, 1-1.5 parts of xanthan gum, 1-1.5 parts of vegetable oil, 1-2 parts of squalene, 5-6 parts of emulsifier, 0.5-1 parts of polysorbate-20, 0.5-1 parts of triethanolamine, 0.5-1 parts of panthenol, 0.1-0.5 parts of thymopenti and 2-3 parts of honey.

(32) The following preparation is carried out according to the above-mentioned ratio of the topical drug for treating breast cancer, comprising the following steps:

(33) (1) mixing Astragalus, Oldenlandia diffusa, dandelion, Lycoris radiate, Carapax trionycis, Pinellia pedatisecta, Acorus calamus, Ferula sinkiangensis, doubleteeth pubescent angelica root, Cryptotaenia japonica Hassk, Whitmania pigra Whitman, Wedelia chinensis, Echinacea purpurea, Folium Eriobotryae, Sedum sarmentosum, Angelicae sinensis, asparagus, scorpio, Rubia cordifolia L., myrrh, nutgrass galingale rhizome and pericarpium citri reticulatae viride together; adding water into the mixture of those components, in which the is weight of the water is 4-5 times the weight of all the mixture; after soaking the mixture at room temperature for 20-25 minutes, decocting it at 80-90 C. for 100-150 minutes; then filtering it to get the filtrate and dregs for later use;

(34) (2) adding 50-60% ethanol solution to the dregs obtained by step (1), in which the weight of the ethanol solution is 4-5 times the weight of the dregs; decocting the mixture at 60-70 C. for 120-160 minutes; then filtering it to get the filtrate and dregs for later use;

(35) (3) heating the filtrate obtained by step (2) to 80-90 C.; and recovering the ethanol and getting the filtrate;

(36) (4) adding 15-18% acetic acid solution to the dregs obtained by step (2), in which the weight of acetic acid solution is 4-5 times the weight of the dregs; decocting the mixture at 40-50 C. for 50-70 minutes; then filtering it to get the filtrate;

(37) (5) letting the temperature of the filtrate obtained by step (1) and step (3) down to 40-50 C., then mixing them with the filtrate obtained by step (4); adding alfalfa extract and extract of Jew's ear from mulberry trees to the combined filtrate; heating and stirring the mixed solution at 40-50 C. until its weight is 1.5-2 times the weight of all herbs; and treating the mixed solution with small molecule cutting technology to retain its activity and effectiveness;

(38) (6) weighing 100-110 parts by weight of water, 4-5 parts by weight of glycerin and 1-1.5 parts by weight of xanthan gum; dissolving and mixing them together; heating the solution to 80 C.; and sterilizing it;

(39) (7) weighing 1-1.5 parts by weight of vegetable oil, 1-2 parts by weight of squalene, 5-6 parts by weight of emulsifier, 0.5-1 parts by weight of polysorbate-20, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of panthenol and 0.1-0.5 parts by weight of thymopentin; mixing them; then heating the mixed solution to 80 C.;

(40) (8) mixing the solution obtained by step (6) and step (7) and stirring evenly; when the mixture being cooled to 40-50 C., adding 2-3 parts by weight of honey and stirring evenly; then keeping the mixed solution at the current temperature for 20-25 minutes;

(41) (9) mixing the solution obtained by step (5) and step (8); then keeping stirring the mixture until its temperature falls to room temperature; and

(42) (10) standing the mixture obtained by step (9) stable, then testing and filling to obtain the finished product.

Example 4

(43) A topical drug for treating breast cancer comprises the following components in parts by weight:

(44) 8 parts of Astragalus, 4 parts of Oldenlandia diffusa, 4 parts of dandelion, 7 parts of Lycoris radiate, 6 parts of Carapax trionycis, 4 parts of Pinellia pedatisecta, 2.5 parts of Acorus calamus, 4 parts of Ferula sinkiangensis, 4 parts of doubleteeth pubescent angelica root, 5 parts of Cryptotaenia japonica Hassk, 4 parts of Whitmania pigra Whitman, 6 parts of Wedelia chinensis, 7 parts of Echinacea purpurea, 5 parts of Folium Eriobotryae, 4 parts of Sedum sarmentosum, 8 parts of Angelicae sinensis, 3 parts of asparagus, 2 parts of scorpio, 7 parts of Rubia cordifolia L., 2 parts of alfalfa extract, 4 parts of extract of Jew's ear from mulberry trees, 6 parts of myrrh, 5 parts of nutgrass galingale rhizome and 5 parts of pericarpium citri reticulatae viride;

(45) auxiliary materials: 100-110 parts of water, 4-5 parts of glycerin, 1-1.5 parts of xanthan gum, 1-1.5 parts of vegetable oil, 1-2 parts of squalene, 5-6 parts of emulsifier, 0.5-1 parts of polysorbate-20, 0.5-1 parts of triethanolamine, 0.5-1 parts of panthenol, 0.1-0.5 parts of thymopenti and 2-3 parts of honey.

(46) The following preparation is carried out according to the above-mentioned ratio of the topical drug for treating breast cancer, comprising the following steps:

(47) (1) mixing Astragalus, Oldenlandia diffusa, dandelion, Lycoris radiate, Carapax trionycis, Pinellia pedatisecta, Acorus calamus, Ferula sinkiangensis, doubleteeth pubescent angelica root, Cryptotaenia japonica Hassk, Whitmania pigra Whitman, Wedelia chinensis, Echinacea purpurea, Folium Eriobotryae, Sedum sarmentosum, Angelicae sinensis, asparagus, scorpio, Rubia cordifolia L., myrrh, nutgrass galingale rhizome and pericarpium citri reticulatae viride together; adding water into the mixture of those components, in which the weight of the water is 4-5 times the weight of all the mixture; decocting it for 100-150 minutes; then filtering it to get the filtrate and dregs for later use;

(48) (2) adding 50-60% ethanol solution to the dregs obtained by step (1), in which the weight of the ethanol solution is 4-5 times the weight of the dregs; decocting the mixture for 120-160 minutes; then filtering it to get the filtrate and dregs for later use;

(49) (3) heating the filtrate obtained by step (2) to 80-90 C.; and recovering the ethanol and getting the filtrate;

(50) (4) adding acetic acid solution to the dregs obtained by step (2), in which the weight of acetic acid solution is 4-5 times the weight of the dregs; decocting the mixture for 50-70 minutes; then filtering it to get the filtrate;

(51) (5) combining the filtrate obtained by step (1), step (3) and step (4); add alfalfa extract and extract of Jew's ear from mulberry trees to the combined filtrate; heating and stirring the mixed solution at 40-50 C. until its weight is 1.5-2 times the weight of all herbs; and treating the mixed solution with small molecule cutting technology to retain its activity and effectiveness;

(52) (6) weighing 100-110 parts by weight of water, 4-5 parts by weight of glycerin and 1-1.5 parts by weight of xanthan gum; dissolving and mixing them together; then heating the mixed solution to 80 C.; and sterilizing it;

(53) (7) weighing 1-1.5 parts by weight of vegetable oil, 1-2 parts by weight of squalene, 5-6 parts by weight of emulsifier, 0.5-1 parts by weight of polysorbate-20, 0.5-1 parts by weight of triethanolamine and 0.5-1 parts by weight of panthenol; mixing them; then heating the mixed solution to 80 C.;

(54) (8) mixing the solution obtained by step (6) and step (7) and stirring evenly; when the mixture being cooled to 40-50 C., adding 2-3 parts by weight of honey and stirring evenly; then keeping the mixed solution at the current temperature for 20-25 minutes;

(55) (9) mixing the solution obtained by step (5) and step (8); then keeping stirring the mixture until its temperature falls to room temperature; and

(56) (10) standing the mixture obtained by step (9), then testing and filling to is obtain the finished product.

Example 5

(57) A topical drug for treating breast cancer comprises the following components in parts by weight:

(58) 8 parts of Astragalus, 4 parts of Oldenlandia diffusa, 4 parts of dandelion, 7 parts of Lycoris radiate, 6 parts of Carapax trionycis, 4 parts of Pinellia pedatisecta, 2.5 parts of Acorus calamus, 4 parts of Ferula sinkiangensis, 4 parts of doubleteeth pubescent angelica root, 5 parts of Cryptotaenia japonica Hassk, 4 parts of Whitmania pigra Whitman, 6 parts of Wedelia chinensis, 7 parts of Echinacea purpurea, 5 parts of Folium Eriobotryae, 4 parts of Sedum sarmentosum, 8 parts of Angelicae sinensis, 3 parts of asparagus, 2 parts of scorpio, 7 parts of Rubia cordifolia L., 2 parts of alfalfa extract, 4 parts of extract of Jew's ear from mulberry trees, 6 parts of myrrh, 5 parts of nutgrass galingale rhizome and 5 parts of pericarpium citri reticulatae viride;

(59) auxiliary materials: 100-110 parts of water, 4-5 parts of glycerin, 1-1.5 parts of xanthan gum, 1-1.5 parts of vegetable oil, 1-2 parts of squalene, 5-6 parts of emulsifier, 0.5-1 parts of polysorbate-20, 0.5-1 parts of triethanolamine, 0.5-1 parts of panthenol, 0.1-0.5 parts of thymopenti and 2-3 parts of honey.

(60) The following preparation is carried out according to the above-mentioned ratio of the topical drug for treating breast cancer, comprising the following steps:

(61) (1) mixing Astragalus, Oldenlandia diffusa, dandelion, Lycoris radiate, Carapax trionycis, Pinellia pedatisecta, Acorus calamus, Ferula sinkiangensis, doubleteeth pubescent angelica root, Cryptotaenia japonica Hassk, Whitmania pigra Whitman, Wedelia chinensis, Echinacea purpurea, Folium Eriobotryae, Sedum sarmentosum, Angelicae sinensis, asparagus, scorpio, Rubia cordifolia L., myrrh, nutgrass galingale rhizome and pericarpium citri reticulatae viride together; adding water into the mixture of those components, in which the weight of water is 4-5 times the weight of all the mixture; after soaking the mixture at room temperature for 20-25 minutes, decocting it at 80-90 C. for 100-150 minutes; then filtering it to get the filtrate and dregs for later use;

(62) (2) adding 50-60% ethanol solution to the dregs obtained by step (1), in which the weight of the ethanol solution is 4-5 times the weight of the dregs; decocting the mixture at 60-70 C. for 120-160 minutes; then filtering it to get the filtrate and dregs for later use;

(63) (3) heating the filtrate obtained by step (2) to 80-90 C.; and recovering the ethanol and getting the filtrate;

(64) (4) adding 15-18% acetic acid solution to the dregs obtained by step (2), in which the weight of acetic acid solution is 4-5 times the weight of the dregs; decocting the mixture at 40-50 C. for 50-70 minutes; then filtering it to get the filtrate;

(65) (5) letting the temperature of the filtrate obtained by step (1) and step (3) down to 40-50 C., then mixing them with the filtrate obtained by step (4); adding alfalfa extract and extract of Jew's ear from mulberry trees to the combined filtrate; heating and stirring the mixed solution at 40-50 C. until its is weight is 1.5-2 times the weight of all herbs;

(66) (6) weighing 100-110 parts by weight of water, 4-5 parts by weight of glycerin and 1-1.5 parts by weight of xanthan gum; dissolving and mixing them together; heating the mixed solution to 80 C.; and sterilizing it;

(67) (7) weighing 1-1.5 parts by weight of vegetable oil, 1-2 parts by weight of squalene, 5-6 parts by weight of emulsifier, 0.5-1 parts by weight of polysorbate-20, 0.5-1 parts by weight of triethanolamine, 0.5-1 parts by weight of panthenol and 0.1-0.5 parts by weight of thymopentin; mixing them; then heating the mixed solution to 80 C.;

(68) (8) mixing the solution obtained by step (6) and step (7) and stirring evenly; when the mixture being cooled to 40-50 C., adding 2-3 parts by weight of honey and stirring evenly; then keeping the mixed solution at the current temperature for 20-25 minutes;

(69) (9) mixing the solution obtained by step (5) and step (8); then keeping stirring the mixture until its temperature falls to room temperature; and

(70) (10) standing the mixture obtained by step (9), then testing and filling to obtain the finished product.

(71) After used the topical drugs for treating breast cancer prepared in Example 1-3, the lumps on patients disappeared or significantly reduced, and the recurrence of breast cancer metastasis is significantly reduced and the cure rate of breast cancer has been effectively improved. Owing to not controlling the temperature of extraction process in Example 4 and not using is small molecule cutting technology for drug treatment in Example 5, the cure rates of breast cancer by Example 4 and 5 declined.

(72) The topical drugs for treating breast cancer and the preparation methods thereof provided by the examples have been described in detail above. The principles and implementation methods of this invention have been expatiated by certain embodiments. The description of the embodiments above is only intended to help to understand the method and the core concept of this invention. Meanwhile, to those generally skilled in the art, the specific implementation ways and application scope can be changed according to the concept of this invention. In conclusion, the contents of this specification should not be construed to a limitation of the present invention.