ION CONDUCTIVE DEVICE WITH CONTROLLED DELIVERY ELECTRODE

Abstract

A device (100) comprising a first electrode (104) provided at or in a source electrolyte (101), and at least one ion conductive channel (103), wherein said first electrolyte (101) is arranged at a first portion (201) of the ion conductive channel (103), and a second electrode (105) provided in a target electrolyte (102), wherein said target electrolyte (102) is arranged at a second portion (202) of the ion conductive channel (103), and wherein said first and second electrodes provides an electrical control of anion flow through the ion conductive channel (103), wherein the device further comprises at least one controlled delivery electrode (114) arranged adjacent to or in the second portion of the ion conductive channel (103), wherein said first and second electrodes further are arranged to provide an electrical control of anion flow through the controlled delivery electrode (114) to the target electrolyte (102), and wherein said controlled delivery electrode (114) is adapted to deliver ions from said ion conductive channel (103) to said target electrolyte (102), and wherein said controlled delivery electrode (114) comprising an electronically and ionically conductive material (107) and an electrical contact (106), wherein said controlled delivery electrode (114) is arranged in ionic contact with, and between, said ion conductive channel (103) and the target electrolyte (102), wherein said electrical contact (106) provides for an electrical control potential (V.sub.CDE) over the controlled delivery electrode (114) to control an ion flow between the controlled delivery electrode (114) and the target electrolyte (102).

Claims

1. A device (100) comprising a first electrode (104) provided at or in a source electrolyte (101), and at least one ion conductive channel (103), wherein said first electrolyte (101) is arranged at a first portion (201) of the ion conductive channel (103), and a second electrode (105) provided in a target electrolyte (102), wherein said target electrolyte (102) is arranged at a second portion (202) of the ion conductive channel (103), and wherein said first and second electrodes provides an electrical control of an ion flow through the ion conductive channel (103) wherein the device further comprises at least one controlled delivery electrode (114) arranged adjacent to or in the second portion of the ion conductive channel (103), wherein said first and second electrodes further are arranged to provide an electrical control of an ion flow through the controlled delivery electrode (114) to the target electrolyte (102), and wherein said controlled delivery electrode (114) is adapted to deliver ions from said ion conductive channel (103) to said target electrolyte (102), and wherein said controlled delivery electrode (114) comprising an electronically and ionically conductive material (107) and an electrical contact (106), wherein said controlled delivery electrode (114) is arranged in ionic contact with, and between, said ion conductive channel (103) and the target electrolyte (102), wherein said electrical contact (106) provides for an electrical control potential (V.sub.CDE) over the controlled delivery electrode (114) to control an ion flow between the controlled delivery electrode (114) and the target electrolyte (102).

2. A device (100) as claimed in claim 1, wherein said electronically and ionically conductive material (107) of the controlled delivery electrode (114) is permselective for either cationic or anionic species.

3. The device (100) as claimed claim 1, wherein the electronically and ionically conductive material (107) includes a conducting polymer such as PEDOT.

4. The device (100) as claimed in claim 1, wherein said electronically and ionically conducting material (107) is adapted to act as a reservoir for ions being injected to, or extracted from the material.

5. The device (100) as claimed in claim 1, wherein said device comprises at least two controlled delivery electrodes (114a, 114b), and wherein said at least two controlled delivery electrodes (114a, 114b) are separated from each other with an ion conductive channel (103) having a finite ion conductivity, to control ion flow from the ion conductive channel (103) into the target electrolyte (102) from each controlled delivery electrode separately.

6. The device (100) as claimed in claim 1, wherein a resistance between the controlled delivery electrode (114) and the target electrolyte (102) is sufficiently high to enable the potential drop between the contact (106) of the controlled delivery electrode and the target electrolyte.

7. The device (100) as claimed in claim 5, wherein the controlled delivery electrodes (114a, 114b) are arranged on or in the same or different ion conductive channels (103, 103a, 103b, 103) and wherein the controlled delivery electrodes (114a, 114b) are separated from each other with a material having a finite ion conductivity.

8. The device (100) as claimed in claim 1, wherein an ion barrier (110) is arranged between the controlled delivery electrode (114) and the target electrolyte (102).

9. The device (100) as claimed in claim 8, wherein the ion barrier (110) comprises a material having a fixed concentration of opposite charges with respect to the fixed charges of the controlled delivery electrode (114).

10. The device (100) as claimed in claim 8, wherein the barrier (110) is adapted to geometrically restrain or limit an ion flow.

11. The device (100) as claimed in claim 1, wherein the device comprises at least two ion conductive channels (103a, 103b), and wherein multiple controlled delivery electrodes (114a, 114b) are arranged in or on said multiple ion conductive channels (103), wherein said controlled delivery electrodes are in ionic contact with the same target electrolyte (102), and wherein the controlled delivery electrodes (114a, 114b) are separated from each other by an ion conductive channel (103) having a finite ion conductivity.

12. The device (100) as claimed in claim 1, wherein the device comprises at least one waste channel (111), and wherein each waste channel comprises a waste electrolyte (112) and a waste electrode (113).

13. A method of operating a device (100) as claimed in claim 1, comprising the steps of: a) providing a source electrolyte (101) comprising the ions to be transported, b) providing a target electrolyte (102) to where the ions are transported, c) bringing the source electrode (104) of the device in contact with the source electrolyte, d) optionally providing a waste electrode (113) and a waste electrolyte (112); e) bringing the second electrode (105) in contact with the target electrolyte (102); f) applying a potential to the source electrode (104), the second electrode (105) and the controlled delivery electrode (114), and optionally to the waste electrode (113), effecting ion transport from the source electrolyte (101), to the controlled delivery electrode (114), or optionally to the waste electrolyte (112); and g) altering the potential of the controlled delivery electrode (114) to switch on ion transport to the target electrolyte (102).

14. (canceled)

15. The method according to claim 13, wherein said target electrolyte comprises any one of tissue, body fluids or cells.

16. The device (100) as claimed in claim 2, wherein the electronically and ionically conductive material (107) includes a conducting polymer such as PEDOT.

17. The device (100) as claimed in claim 5, wherein a resistance between the controlled delivery electrode (114) and the target electrolyte (102) is sufficiently high to enable the potential drop between the contact (106) of the controlled delivery electrode and the target electrolyte.

18. The device (100) as claimed in claim 5, wherein an ion barrier (110) is arranged between the controlled delivery electrode (114) and the target electrolyte (102).

19. The device (100) as claimed in claim 18, wherein the ion barrier (110) comprises a material having a fixed concentration of opposite charges with respect to the fixed charges of the controlled delivery electrode (114).

20. The device (100) as claimed in claim 9, wherein the barrier (110) is adapted to geometrically restrain or limit an ion flow.

21. The method according to claim 13, wherein said device comprises at least two controlled delivery electrodes (114a, 114b), and wherein by controlling the electric potentials at said at least two controlled delivery electrodes (114a, 114b), the ion delivery at multiple sites in a target electrolyte are controlled individually, although the potentials of the source, target and waste electrolytes are kept constant.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0054] Embodiments of the present solution will now be described, by way of example, with reference to the accompanying schematic drawings.

[0055] FIG. 1 is a schematic side view of the device comprising a single ion conductive channel and a single controlled delivery electrode device.

[0056] FIG. 2 is a schematic side view of the device with an enlarged controlled delivery electrode.

[0057] FIG. 3 is a schematic side view of the device with a single ion conductive channel and multiple controlled delivery electrodes placed in series.

[0058] FIG. 4 is a schematic side view of the device with multiple ion conductive channels, each having a controlled delivery electrode.

[0059] FIG. 5 is a schematic side view of a controlled delivery electrode with a barrier layer.

[0060] FIG. 6 is a schematic side view of a controlled delivery electrode with a barrier based on geometry.

[0061] FIG. 7 is a schematic side view of the device having multiple ion conductive channels and multiple controlled delivery electrodes.

[0062] FIG. 8 is a schematic top view of the device having a controlled delivery electrode, with multiple source electrolytes and a single target electrolyte.

[0063] FIG. 9 is a schematic top view of the device having controlled delivery electrodes, with a single source electrolyte and multiple target electrolytes.

[0064] FIG. 10 is a schematic top view of the device having multiple controlled delivery electrodes provided in parallel in the ion conductive channel.

[0065] FIG. 11 is a schematic side view of the device comprising a controlled delivery electrode and a separate waste electrolyte.

[0066] FIG. 12a is a schematic graph showing an approximate potential path through the barrier.

[0067] FIG. 12b is a schematic graph showing an approximate potential path through controlled delivery electrode to the waste.

[0068] FIG. 13a shows a graph of a delivery pulse.

[0069] FIG. 13b show that the target current is the sum of the source, waste and controlled delivery electrode currents.

[0070] FIG. 14 is a graph showing delivery levels and delivery response time for a standard ion pump OEIP according to the dotted line and the solid line according to the invention having a controlled delivery electrode.

[0071] FIG. 15 is a schematic side view of a device system having one source electrolyte and two encapsulated hoses/pipe-like structures which both are connected to a common waste electrolyte. The device having multiple ion conductive channels, each provided with one or more barrier equipped controlled delivery electrodes which are all in connection with a common target electrolyte.

[0072] FIG. 16 shows a schematic top view of a device system having three ion conductive channels, each provided with a barrier equipped controlled delivery electrode in connection with a target electrolyte and each channel in connection to a common source electrolyte and a common waste electrolyte.

[0073] FIG. 17 is a schematic side view of a prior art charged drug device.

[0074] FIG. 18 is a schematic side view of the prior art Organic Electronic Ion Pump (OEIP).

DESCRIPTION OF EMBODIMENTS

[0075] FIG. 1 shows a device 100 or system according to the invention describing the source electrolyte 101 comprising a first electrode 104, also denoted source electrode, a target electrolyte 102 which includes a second electrode 105, also denoted target electrode and a ion conductive channel 103 having a first end 201 and a second end 202.

[0076] The device 100 or system can either be constructed as a polyanion system or a polycation system depending on the fixed charges of the polymer of the permselective ion conductive channel.

[0077] The ion conductive channel 103 should be designed or treated in such a way as to minimize/reduce electronical conductivity, but preserve or provide ionic conductivity, e.g. by a polystyrene sulfonate (PSS)-derivate or doping.

[0078] Each respective controlled delivery electrode 114, 114a, 114b, see e.g. FIG. 1, FIG. 3, FIG. 4 or FIG. 10, comprises polymers having both electronic and ionic conductivity, connected to an electrical contact 106, 106a, 106b. The controlled delivery electrodes are separated by a portion of the ion conductive channel 103, 103a, 103b, see FIG. 3, FIG. 7 or FIG. 15.

[0079] The ion conductive channel 103 and the controlled delivery electrodes 114, 114a, 114b may be insulated from the electrolytes through an electronically and ionically insulating layer 108, which also minimizes transport of water. On a plane surface, this insulation may consist of a wall, or in tissue, of pipe-like structure with openings through the insulation layer for the respective controlled delivery electrode.

[0080] It is preferred that the potential V.sub.s over the source electrode and the target electrode is kept at a constant value. The ion conductive channel can then be filled with ions by creating a potential over the channel e.g. by making a difference in potential V.sub.CDEa and V.sub.CDEb between the respective controlled delivery electrode and the target electrode see FIG. 3 for a given constant source electrode potential. If for example, the source electrode has a potential of 10 volt, the target electrode 0 volt and the electrical contact of a controlled delivery electrode 0.4 volt, then positive ions will be collected at that controlled delivery electrode.

[0081] To achieve delivery of ions, the electrical contact 106 of a controlled delivery electrode is switched from negative to positive potential versus the target electrode 105. This will make the positive ions move into the target electrolyte. By quickly altering the internal state of the electronically and ionically conductive material 107, a burst of ions will be quickly repelled from the electronically and ionically conductive material 107 and delivered to the target electrolyte. The electronically and ionically conductive material 107 can be enlarged as seen in FIG. 2, to be able to increase the burst of ions see FIG. 14. Hence a larged and well defined amount of ions or drugs can be quickly delivered into the target electrolyte 102.

[0082] FIG. 12, FIG. 13 and FIG. 14 show the potential profile and currents at different parts of the device 100 when the control voltage is applied. FIG. 12a and FIG. 12b show approximate potential profiles along two pathways in the device. FIG. 12a shows the potentials ions would experience in travelling from the source electrolyte to the target electrolyte and to the waste electrolyte. A controlled delivery electrode that is ON will have a negative potential gradient from the controlled delivery electrode 114 through the barrier 110 to the target electrolyte, meaning that the diode is forward biased, which makes cations move from the electronically and ionically conductive material 107 to the target electrolyte and anions from the target electrolyte into the electronically and ionically conductive material 107. For a controlled delivery electrode that is OFF, the potential gradient from the electronically and ionically conductive material 107 to the target electrolyte is instead positive, which attracts cations toward the electronically and ionically conductive material 107 and cations toward the polycation in polyanion/polycation interface, thus the diode is reverse-biased and the interface is depleted of ions, leading to a low current.

[0083] FIG. 13 shows measured currents i.sub.Source, i.sub.Waste, i.sub.CDE and the calculated i.sub.Target when switching from reverse to forward bias in a one second long delivery pulse (i.sub.Target=i.sub.Source+i.sub.Waste+i.sub.CDE) from a single controlled delivery electrode. The voltage of the electronically and ionically conductive material 107 is switched between 0.5 V, relative to the target potential. A diode behavior can be noted (high target current in forward bias, and low in reverse bias). In reverse bias, the controlled delivery electrode is refilled with ions from the source.

[0084] FIG. 14 shows the current of intended molecules to be delivered, not the overall current. For example, if a substance in a prior art ion pump (dashed line) is to be delivered, there will be a delay of t before the molecule makes it to the delivery site. Even if the channel is prefilled, there will still be a rise time due to some passive diffusion at the very tip (i.e., same dashed curve shape even if t=0). The solid line is the burst achieved from a controlled delivery electrode according to the invention.

[0085] A physical or functional barrier layer 110 as illustrated in FIG. 5, improves the functionality by allowing individual addressing with highly reduced leakage.

[0086] The barrier may be based on an oppositely charged material, compared to the charge of the permselective ion conductive channel and the net charge of the material in the controlled delivery electrode.

[0087] The barrier 110 may also comprise a small-area hole, as illustrated by FIG. 6, or a hole with a high height-to-area aspect ratio. In either case, the effect of the barrier or barrier layer is to minimize the reverse current needed to prevent leakage, which prevents local depletion of cations at the delivery site. The barrier can also be constructed using previously known ionic diodes.

[0088] The device 100 or device system can be extended to include a waste portion comprising a waste channel 111 leading to a waste electrolyte 112 and a waste electrode 113, see as illustrated in FIG. 11, FIG. 15 or FIG. 16. The waste is used to carry away ions and to provide the means of a constant flow of ions through the ion conductive channels and controlled delivery electrodes. This facilitates the filling of the ion conductive channel. The waste thus increases the speed with which the controlled delivery electrode is filled with ions.

[0089] When an alternating current is applied as V.sub.CDE a serial burst effect is achieved.

[0090] The device 100 or system may be used with a common target electrolyte but different source electrolytes as illustrated in FIG. 8, and where the different source electrolytes include different substances or medical drugs to be delivered.

[0091] Alternatively, the device 100 or system can be used with a common source electrolyte but with different target electrolytes, see FIG. 9, and where the target electrolytes are located at different places to receive the same type of substance or medical drug.

[0092] FIG. 17 shows a schematic side view of a prior art charged drug device. Charged drugs have been incorporated as counter ions into conducting polymers. The drug (counter ions) is expelled and released from the conducting polymer 115 when the charge of the polymer is altered as a function of oxidation or reduction,

Definitions Used in the Description

Ions

[0093] The term ion as used herein encompasses not only positively or negatively charged monovalent or multivalent ionic species of atomic elements, but also other molecular species carrying a net positive or negative charge. Hence, in an embodiment of the invention it is intended to transport charged biologically active molecules or macromolecules such as charged amino acids, vitamins, peptides, neurotransmitters, hormones, and substances e.g. pharmaceuticals or endogenous substances. In one embodiment of the invention, the ions that may be transported are cations, for example metal ions, such as potassium or calcium ions. In another embodiment of the invention the ions that may be transported are anions.

Ionic Contact

[0094] A first and a second material are in ionic contact when a substantial amount of ions comprised in the first material can move from the first material to the second material, possibly via a third material. The ionic movement may be caused by diffusion or by an applied electric field.

[0095] A material which provides an ionic connection between a first and a second material, is a material which is ionically conductive, thus electrically conductive (distinguished from being electronically conductive), and in ionic contact with both said first and said second material.

Directly or Indirectly Attached

[0096] Two parts which are directly attached to each other are in direct physical contact with each other. With respect to this invention, when a first part is directly attached to a second part, which second part is directly attached to a third part, said first and third parts are referred to as being indirectly attached to each other. Similarly, when said third part is directly attached to a fourth part, said first and fourth parts are referred to as being indirectly attached to each other.

Semi-Solid Material

[0097] The term semi-solid material refers to a material, which at the temperatures at which it is used has a rigidity and viscosity intermediate between a solid and a liquid. Thus, the material is sufficiently rigid such that it does not flow or leak. Further, particles/flakes in the bulk thereof are substantially immobilized by the high viscosity/rigidity of the material.

[0098] In a preferred case, a semi-solid material has the proper rheological properties to allow for the ready application of it on a support as an integral sheet or in a pattern, for example by conventional printing methods. After deposition, the formulation of the material should preferably solidify upon evaporation of solvent or because of a chemical cross-linking reaction, brought about by additional chemical reagents or by physical effect, such as irradiation by ultraviolet, infrared or microwave radiation, cooling etc.

[0099] The semi-solid or solidified material preferably comprises an aqueous or organic solvent-containing gel, such as gelatin or a polymeric gel.

Electrochemically Active Material

[0100] With respect to this invention the term electrochemically active material refers to a material which is capable of being oxidized or reduced when it is in contact with an electrolyte, or another ionically conductive material, and a voltage is maintained across it. Examples of such electrochemically active materials include electrically conductive polymers, as will be described below, and certain metal oxides, such as indium tin oxide (ITO) and tungsten oxide (WO.sub.3).

Electrolyte

[0101] The device may comprise three different electrolytes. It is important to distinguish between the three (source, target, and waste): the source electrolyte contains the ions to be delivered and should not contain a high extent of other ionic species with the same charge (positive or negative) as the ion to be delivered. The target electrolyte may be the body fluid or the cell culture medium, or whatever media needed for the application. Thus, the content of this electrolyte can often not be controlled, but it must be determined from the application of the device. The waste electrolyte serves as a waste for the ions that are transported from the source, and those ions must thus be soluble in this electrolyte.

[0102] The electrolyte for use with the device or method of the present invention must be based on a solvent that permits ionic conduction in the electrolyte, i.e. that allows for the dissociation of ionic substances such as salts, acids, bases, etc. The solvent and/or the ionic substance may contribute nucleophiles. Possible electrolytes for use in combination with the inventive device are solutions of salts, acids, bases, or other ion-releasing agents in solvents that support the dissociation of ionic species, thus allowing ionic conductivity. In applications where it is required, the target electrolyte may comprise buffer solutions, such as buffer solutions suitable for use with living organisms or biomolecules, such as proteins. Examples of such buffers include NaHPO.sub.4 and sodium acetate. As other non-limiting examples of possible electrolytes, mention can be made of: aqueous solutions of potassium acetate, calcium acetate, NaCl, Na.sub.2SO.sub.4, H.sub.3PO.sub.4, H.sub.2SO.sub.4, KCl, RbNO.sub.3, NH.sub.4OH, CsOH, NaOH, KOH, H.sub.2O.sub.2; organic solvents such as acetonitrile, pyridine, DMSO, DMF, dichloromethane, etc., in combination with suitable salts, such as lithium perchlorate and tertiary ammonium salts, e.g. tetra-butyl ammonium chloride; inorganic solvents such as hypercritical CO.sub.2, liquid SO.sub.2, liquid NH.sub.3, etc., in combination with salts that dissociate in these solvents; solvents displaying auto-dissociation, which results in the formation of ionic species, such as water, formic acid and acetic acid.

[0103] The term electrolyte also encompasses solutions comprising charged biologically active molecules or macromolecules such as charged amino acids, proteins, vitamins, peptides or hormones. An electrolyte may also comprise cell culturing media or ingredients thereof, such as proteins, amino acids, vitamins and growth factors.

[0104] The electrolyte may also be in a semi-solid or solidified form, preferably comprising an aqueous or organic solvent-containing gel as described above. However, solid polymeric electrolytes are also contemplated and fall within the scope of the present invention. Furthermore, the term electrolytes also encompasses liquid electrolyte solutions soaked into, or in any other way hosted by, an appropriate matrix material, such as a paper, a fabric or a porous polymer.

Electrodes in the Electrolytes

[0105] The source, target and optionally the waste electrodes that control the potential of the three respective electrolytes may each comprise a material or a combination of materials which is capable of electron-to-ion conversion, i.e. they need to enable charge transfer between the electrode and its contact and the electrodes must be so called non-polarizable electrodes.

[0106] The electrodes of the inventive device may preferably comprise an electrochemically active material, for example Ag/AgCl. Said electrode material may also be an organic material, for example an electrically conductive polymer. Electrically conductive polymers suitable for use in the device of the invention, are preferably selected from the group consisting of polythiophenes, polypyrroles, polyanilines, polyisothianaphthalenes, polyphenylene vinylenes and copolymers thereof such as described by J C Gustafsson et al. in Solid State Ionics, 69, 145-152 (1994); Handbook of Oligo- and Polythiophenes, Ch 10.8, Ed D Fichou, Wiley-VCH, Weinhem (1999); by P Schottland et al. in Macromolecules, 33, 7051-7061 (2000); Technology Map Conductive Polymers, SRI Consulting (1999); by M Onoda in Journal of the Electrochemical Society, 141, 338-341 (1994); by M Chandrasekar in Conducting Polymers, Fundamentals and Applications, a Practical Approach, Kluwer Academic Publishers, Boston (1999); and by A J Epstein et al. in Macromol Chem, Macromol Symp, 51, 217-234 (1991). The the electrically conductive polymer may preferably a polymer or copolymer of a 3,4-dialkoxythiophene, in which said two alkoxy groups may be the same or different or together represent an optionally substituted oxy-alkylene-oxy bridge. It is particularly preferred that the polymer is a polymer or copolymer of a 3,4-dialkoxythiophene selected from the group consisting of poly(3,4-methylenedioxythiophene), poly(3,4-methylenedioxythiophene) derivatives, poly(3,4-ethylenedioxythiophene), poly(3,4-ethylenedioxythiophene) derivatives, poly(3,4-propylenedioxythiophene), poly(3,4-propylenedioxythiophene) derivatives, poly(3,4-butylenedioxythiophene), poly(3,4-butylenedioxythiophene) derivatives, and copolymers therewith.

[0107] The electrically conductive polymer may be poly(3,4-ethylenedioxythiophene) (PEDOT). The electrodes may further comprise a polyelectrolyte compound, more preferably said polyelectrolyte compound is poly(styrene sulfonic acid) or a salt thereof. One especially preferred material for use in the electrodes of the device of the invention is poly(3,4-ethylenedioxythiophene) with a poly(styrene sulfonate) polyanion (in the following referred to as PEDOT:PSS). The electrodes may be present in the form of a thin layer of PEDOT:PSS deposited on a solid substrate.

[0108] The electrodes may alternatively be Ag/AgCl, painted on the device, or dipped into the electrolytes.

[0109] The source, target and waste electrodes of the inventive device may further comprise a hydrogel. The hydrogel is preferably based on polymers selected from the group consisting of polyacrylates, such as poly(2-hydroxyethyl methacrylate) and poly(acrylamide), polyelectrolytes, such as poly(styrene sulfonic acid) (PSS) and poly(acrylic acid) (PAA), polysaccharides, such as agarose, chitosan and dextran, gelatin, polyvinyl alcohol, polyvinyl pyrrolidone and polyethylene glycol.

[0110] The electrodes are preferably arranged in a common plane on a solid substrate or dipped into the electrolyte. The electrodes can be additively patterned onto said substrate, e.g., by spincoating, painting, printing, or lamination techniques, or subtractively patterned, e.g., by etching.

[0111] At least the target electrode should be biocompatible, since it may be in contact with body fluid or cell culture medium. The term biocompatible is used herein to characterize a material or a surface allowing cultivation of cells thereon or in close association therewith, or the lack of a bodily immunoresponse or similar upon implantation. Cultivation of cells refers to attachment, maintenance, growth and/or proliferation of said cells. An example of an electrode material according to the invention that provides a biocompatible surface is PEDOT:PSS. The biocompatibility of an electrode allow for studies of cellular activities in cells cultivated on or in close association with the electrode.

The Controlled Delivery Electrode

[0112] In order to control the delivery of ions to or from each outlet 109, the device comprises at least one controlled delivery electrode (CDE) 114 which is arranged at or in connection with each delivery site/outlet 109 as illustrated in FIG. 1. The controlled delivery electrode comprises an electronically and ionically conductive material 107, such as an electronically and ionically conductive polymer, and an electrical contact 106. The electronically and ionically conductive material may be PEDOT as described above but also porous metals and supercapacitors.

[0113] The electrical contact may be a metal or other conductive material.

[0114] The potential from the source to the target is kept constant, but the potential at each controlled delivery electrode may be varied to control the delivery from each outlet respectively.

[0115] The electronically and ionically conductive material 107 in combination with a barrier 110 can be seen as an ion diode, where one portion 107 of the diode that is contacted by the electrical contact 106 is electronically as well as cationically (or anionically) conducting. The other part 110 of the diode (the portion that contacts the target electrolyte) is not electronically conducting, but is merely a polycation or polyanion (or any other porous material with fixed charges opposite to the fixed charges of the other half of the diode) and thus acts as a barrier as shown in FIG. 5. The diode does not necessarily consist of two oppositely charged materials, but can also be formed by the conducting polymer/polyelectrolyte blend (or other conducting material with an excess of fixed charges positive or negative) and a small hole with high aspect ratio.

[0116] The potential across the controlled delivery electrode and the target electrolyte sets the diode in forward or reverse bias and determines whether ions can pass through it and be delivered to the outlet in the target electrolyte.

REFERENCE LIST

[0117] 100 device or device system [0118] 101 source electrolyte [0119] 102 target electrolyte [0120] 103 ion conductive channel [0121] 103 ion conductive channel between the controlled delivery electrodes [0122] 104 first electrode or source electrode [0123] 105 second electrode or target electrode [0124] 106 electrical contact [0125] 107 electronically and ionically conductive material [0126] 108 electronically and ionically insulating layer [0127] 109 delivery site/outlet [0128] 110 barrier [0129] 110 barrier based on geometry [0130] 111 waste channel [0131] 112 waste electrolyte [0132] 113 waste electrode [0133] 114 controlled delivery electrode (CDE) comprising electrical contact 106 and electronically and ionically conductive material 107 [0134] 115 conducting polymer (in prior art) [0135] 201 first end of ion conductive channel 103 [0136] 202 second end of ion conductive channel 103