Fluid transfer device

Abstract

A disposable device for the sterile transfer of fluids, such as liquids or gases, includes a body, a bore formed through at least a portion of the interior of the body, and a linearly moveable plunger contained within the bore. The body is formed from a rotating section and a stationary section. Partial rotation of the rotating section around a portion of the stationary section and the plunger drives the plunger linearly within the bore, opening and closing the device. The plunger includes at least a first and a second opening, and a fluid channel in the interior of the plunger connecting the first and second openings forming a fluid pathway to downstream components when the device is open. A termination component at one end of the plunger connects to a downstream component. A flange at one end of the body attaches to an upstream component. When the device is closed, the upstream end of the plunger is in alignment with the upstream flange of the body, forming a steamable sterilized in place face and a sterile barrier.

Claims

1. A fluid transfer device comprising: a body; an elongate passage having an interior wall and extending through the body and having a proximal end and a distal end; a longitudinally displaceable plunger disposed in and extending along the passage, the plunger having a proximal end and a distal end and having a first position displaced toward the distal end of the passage and a second position displaced toward the proximal end of the passage; at least one static diaphragm seal mounted on the proximal end of the plunger to form a fluid tight seal between the plunger and the passage, said static diaphragm seal remaining intact during movement of said plunger from said first position to said second position and back to said first position; a gland seal; and a fluid transfer opening positioned between the proximal end of the plunger and the distal end of the plunger; wherein the body comprises a first section and a second section, wherein rotation of the first section relative to the second section causes longitudinal displacement of the plunger, and wherein the longitudinal displacement of the plunger towards its first position opens the passage to form a substantially aseptic fluid pathway from an upstream component to a downstream component through the fluid transfer opening and a channel in the interior of the plunger; and wherein the gland seal is arranged along a length of the plunger, a first portion of the gland seal being retained within a groove on a surface of the first section of the body and a second portion of the gland seal being retained within a groove on the plunger, and wherein the gland seal stretches to accommodate the displacement of and maintain a seal about the plunger.

2. The device of claim 1, wherein the diaphragm seal is attached to the proximal end of the plunger and seals the passage at the proximal end thereof.

3. The device of claim 2, wherein the diaphragm seal is disposed at least partially inside the proximal end of the passage prior to displacement of the plunger.

4. The device of claim 1, wherein the gland seal seals the passage at a location intermediate the diaphragm seal and the distal end of the passage.

5. The device of claim 1, wherein the plunger extends through and is sealingly secured to the gland seal.

6. The device of claim 1, further comprising a substantially aseptic tank mount.

7. The device of claim 1, wherein the at least one seal is constructed of a silicone elastomer.

8. The device of claim 1, wherein the at least one seal is constructed of a solvent resistant fluoroelastomer.

9. The device of claim 1, wherein the body comprises a substantially cylindrical outer portion, and at least one alignment slot for the plunger.

Description

IN THE DRAWINGS

(1) The present invention will become more fully understood from the detailed description given herein below and the accompanying drawings which are given by way of illustration only, and thus are not limitative of the present invention, and wherein:

(2) FIG. 1a is a cross sectional view of an embodiment of the present invention in a closed position;

(3) FIG. 1b is a cross section taken along line 1b-1b;

(4) FIG. 2 is a cross sectional view of the embodiment of the present invention of FIG. 1 in an opened position;

(5) FIGS. 3a and 3b are perspective views of additional embodiments of the present invention of FIG. 1, along with alternative embodiments of upstream and downstream attachment components; and

(6) FIGS. 4a and 4b are perspective views of an embodiment of the present invention of FIG. 1.

DETAILED DESCRIPTION OF THE INVENTION

(7) In general, the present invention is a sterile fluid transfer device, such as a flow-through connector or valve, wherein the fluids are liquids and/or gases. In one embodiment, the fluid transfer device has a body, a bore located in the interior of the body, and a linearly movable plunger contained within the bore. The body is formed from a first and a second section. The first section has a first end containing a first opening and a termination attachment component, such as a flange or the like surrounding the first opening for attaching the body to an upstream component(s). The second section has a second end containing a second opening, wherein the bore connects the first and second openings. The first section rotates around a portion of the second section.

(8) The linearly movable plunger includes a first end containing a first opening, a second end containing a second opening, a fluid channel located in the interior of the plunger connecting the first and second openings of the plunger. In one embodiment, the plunger includes a component for inhibiting its rotation, while promoting its linear movement within the bore during rotation of the first section of the body when the device is actuated (i.e., opened/closed).

(9) The fluid transfer device is in the closed position when the first end of the plunger is in alignment with the termination attachment component surrounding the first opening of the body, thereby forming a fluid resistant seal and a steamable face. The device is in the opened position when the first end of the plunger is not in alignment with the termination attachment component surrounding the first opening of the body, thereby permitting fluids to enter the device from an upstream component.

(10) To the extent that the same reference numbers apply to the figures they have been kept the same.

(11) One embodiment of the invention shown in FIGS. 1a and 2 includes a device 12 having a body 14 having a bore 20 formed through at least a portion of the interior of the body, and a generally hollow moveable plunger 62 contained within the bore. Bore 20, as shown, is a lateral central bore formed through the entire interior length of the body 14. Body 14, as shown, is formed from two sections, a rotating first section 26 and a stationary second section 28. First section 26 rotates partially around a portion of the stationary second section 28 and plunger 62. Bore 20, as shown, is formed of two sections, a rotating bore section 34 which generally corresponds to the inner wall of rotating first section 26, and a stationary bore section 36 which generally corresponds to the inner wall of stationary second section 28. In the embodiment depicted in FIGS. 1a and 2, each of the bore sections (34, 36) has different diameters. As will be described in greater detail herein, device 12 is actuated (i.e., opened/closed) when first section 26 of the body is rotated, engaging second section 28 of the body and plunger 62, driving the plunger linearly within the bore 20, thereby actuating (i.e., opening and closing) the device.

(12) As shown in FIGS. 1a and 2, the first section 26 of the body 14 is generally hollow and has an opening 18 at one end for receiving the plunger. As shown in FIGS. 1a and 2, the first section 26 includes a protruding lip or edge component 38 that is rotatably engaged by a stationary wall receiving groove 44 on the outer stationary 28 wall section.

(13) In FIG. 2, the first section 26 also includes an inner wall having a stationary wall engaging section 40, and forms a rotating bore section 34 having four sections. There is a first rotating bore set diameter 34a, a transition rotating bore section 34b, a second rotating bore diameter 34c and a third rotating bore diameter 34d. The first set diameter 34a engages the plunger as it moves linearly within the bore 20. The transition section 34b is arranged between the first and second diameters (34a, 34c) and has an outwardly tapering diameter along its length. The diameter of the transition section 34b is preferably a linear outward progression from the first diameter section 34a, wherein the diameter of the transition section 34b adjacent the first diameter 34a is equal to the first diameter 34a, and the diameter of the transition section 34b adjacent the second diameter 34c is equal to the diameter 34c. The third diameter 34d is preferably less than diameter 34c and preferably greater than the diameter 34a.

(14) As shown in FIGS. 1a and 2, the stationary second section 28 of the body 14 is generally hollow and has an opening 16 at one end that permits a fluid provided from an upstream source (not shown) to pass through it when opened. The opening 16 also receives the bottom 63 of the plunger when the device is closed. The stationary section 28 includes an outer wall component 42 for rotatably engaging the inner wall section 40 of the rotating section 26. As shown in FIGS. 1a and 2 the inner wall of the second section 28 forms the stationary bore section 36 having four sections. There is a first stationary bore diameter 36a, a first transition stationary bore section 36b, a second stationary bore diameter 36c, and a second transition stationary bore section 36d. The first bore diameter 36a is less than the second bore diameter 36c. The second bore diameter 36c is a set diameter. The first transition bore section 36b is arranged between the first and second bore diameters (36a, 36c) and has an outwardly tapering diameter along its length. The diameter of the first transition section 36b is preferably a linear outward progression between the first and second bore diameters (36a, 36c). The diameter of the first transition section 36b adjacent the first diameter 36a is equal to the diameter 36a, and the diameter of the first transition section 36b adjacent the second diameter 36b is equal to the diameter 36b.

(15) As shown in FIGS. 1a and 2 plunger 62 has three general regions comprising a first, second and third region. The first region 24 has a diameter equal to or less than the first rotating bore set diameter 34a. The second region 25 has a diameter equal to or less than the second stationary bore diameter 36c. The third region 29 has a diameter equal to or less than that of the first stationary bore diameter section 36a. The plunger has a bottom component 63 at the end of the third region 29 for blocking the opening 16 of the stationary section 28 when the device is in the closed position, as shown in FIG. 1a. One embodiment of the invention as depicted in FIGS. 1a and 2 includes a static diaphragm seal 60 located on the bottom 63 of the plunger forming a tight fluid resistant seal between the outer wall 61 of the bottom end 63 of the plunger, and the inner wall 82 of stationary section 28 of the body forming the opening 16.

(16) Plunger 62 also has at least two openings, a first opening 64 and a second opening 66. A channel 68 is located in the interior of the plunger and connects the first and second openings (62, 64), thereby forming a fluid pathway to a downstream component. As shown in FIGS. 1a and 2, the first opening 64 is located in the first portion 24 of the plunger, and the second opening 66 is located in the second portion 25 of the plunger. In other embodiments, plunger 62 can contain additional openings and interior fluid pathways. In one preferred embodiment, the plunger contains at least openings in the second portion 25. (not shown)

(17) One embodiment of the invention as depicted in FIGS. 1a and 2 includes plunger 62 having a component for inhibiting the rotation of the plunger within the bore, while promoting linear movement of the plunger when the fluid transfer device 12 is actuated (i.e., opened/closed). One embodiment for accomplishing the linear movement of the plunger, as shown in FIGS. 1a and 2, depicts the plunger having a pair of wings (74, 76), fins, or the like, that extend from the outer wall of the plunger towards the inner wall of the second section 28 of body 14. Second section 28 has a component for interacting with wings (74, 76) comprising two corresponding pairs of parallel slots (70, 72), grooves, or the like located on the inner wall of the section 28 for receiving the wings (74, 76) in order to restrict the rotation of the plunger 62 and promote the linear movement of the plunger within the bore 20. Wings (74, 76) ride between each corresponding pair of slots (70, 72) thereby facilitating the linear movement of the plunger within the bore during actuation (opening/closing) of the device 12.

(18) As shown in FIG. 1a, when device 12 is in the closed position the bottom end 63 of the plunger is in alignment with flange 80, forming a face 90, and providing the device with a steamable surface and a sterile barrier against the environment for the interior of the device, plunger and any downstream components. In the closed position, the bottom end 63 of the plunger does not permit fluid to enter opening 16 in the device from an upstream component (not shown), thereby preventing any fluid from traveling downstream.

(19) As shown in FIG. 2, device 12 is in the opened position when the plunger 62 is linearly moved within the lateral bore 20 by the rotation of section 26 of the body 14, such that the bottom end 63 of the plunger 62 is moved back from the flange 80, permitting fluid, depicted by an arrow, to travel from an upstream component (not shown), through opening 16 in section 28 of the body. The fluid then travels through the second hole 66 of the plunger, into the interior channel 68 of the plunger, out opening 64, and into a downstream component. (not shown) Plunger 62 is not permitted to rotate within the bore during the rotation of the rotating section 26, but is forced to move linearly by wings (74, 76) of the plunger located within the parallel slots (70, 72) on the inner wall of section 28.

(20) Additionally, by preventing the plunger from rotating when the device is opened or closed, the problem of torsion between device 12 and an attached upstream or downstream component can be averted, since it is not necessary to twist or turn the upstream or downstream components, or the device, when removing or actuating the device since the plunger moves within the bore linearly, and not rotationally.

(21) As shown in FIGS. 3a, 3b, 4a, and 4b, the plunger 62 can contain one or more cams 56 (only one shown) that ride in one or more cam slots 58 (only one shown) located in the rotating section 26 of the body 14. The arrangement of the cam 56 and slot 58 acts to limit the length the plunger 62 travels linearly within the bore 20 when the device is actuated (opened or closed). When device 12 is in the closed position, as shown in FIG. 4a, the cam 56 sits in the closed position of the cam slot 58. When device 12 is in the opened position, as shown in FIG. 4b, the cam 56 sits in the opened position of the calm slot 58. The arrow in FIG. 4b depicts the rotational movement of rotating section 26 and cam slot 58.

(22) As shown in FIGS. 3a and 3b, device 12 has at one end of the stationary section 28 of the body a component for attaching the device to an upstream component. In this embodiment, a flange 80 attaches to a flange 88 of an upstream component. As shown in FIG. 3a, the end of the first plunger region 24 includes, in this embodiment, a barb termination 92 for connecting the device to a downstream component, in this instance, tubing 72.

(23) As shown in FIG. 3b, the end of first plunger portion 24 includes, in this embodiment, a termination flange 94 for connecting the device to a downstream component, in this embodiment, a termination flange 78.

(24) By way of example, the downstream components attached to the device by the termination connection feature on the plunger can be plastic tubing 72 and the like, as shown in FIG. 3a, attached to a plastic bag or other type of known receptacle (not shown), and the like.

(25) By way of example, the upstream component attached to the device can be a pipe, a stainless steel or disposable plastic tank having an outlet, and the like, having an attachment flange 88 (as depicted in FIGS. 3a and 3b), or any other mode of attachment for connecting components to transfer devices as are commonly known in the art. For example, flange 80 on device 12 can be connected to an upstream component or pipe by a clamp such as a Tri-Clover fitting, Ladish fitting, ClickClamp clamp and the like.

(26) When using device 12 to fill a downstream component such as a bag, or any collection vessel attached the tubing 72, the device is opened by rotating section 28 of the body, which moves the plunger 62 linearly (see FIG. 4b) away from the face 90, permitting fluid to enter opening 16 (see FIG. 2) and to eventually flow out the opening exit 64 through tube 72, and into a bag, or any collection vessel or other fluid transport device. (not shown) Once a bag is full, the rotating section 28 is rotated in the opposite direction to move the plunger linearly again, this time in the opposite direction, in order to seal the opening 16 closed (see FIG. 1) to the fluid from an upstream component. By way of example, an attached bag can then be closed off via a clamp or hemostat (not shown) and removed for further processing or use.

(27) One or more seals are arranged along the length and end of the plunger 62 to form a fluid tight seal between various portions of the plunger 62 and the bore 20 when the device is in the closed or opened positions. As shown in FIGS. 1a and 2, seals 60 and 54 are partly contained within grooves 48, and 46 and 44 respectively.

(28) As shown in FIGS. 1a and 2, the seals may be mounted on the plunger 62. However, if desired, a different configuration of seals and their placements can also be used. For example, FIGS. 1a and 2 show seals 46 and 60 formed in grooves on the plunger 62. A linear or gland seal 51 is retained within a groove 50 on the inner wall of the stationary bore section and within a groove 46 on the plunger 62.

(29) Other embodiments of the present invention are also contemplated, such as molding the device 12 into a disposable plastic container such as a disposable process bag for the manufacture and transfer of biotech products and the like. Such bags are readily available from companies such as HyClone (which is part of Thermo Fisher Scientific) of Logan, Utah and Stedim Biosystems of Concord, Calif.

(30) Since the fluid transfer device 12 is preferably provided in a sterile condition, (i.e., the interior of the system and any component connected downstream of the device is pre-sterilized such as with gamma radiation, ethylene gas or the like and shipped in a sterile condition), some type of use indicator (not shown) may be helpful, and capable of informing a user when a system has been used. As an alternative, or in addition to any of the indicator mechanisms discussed above, a shrink wrap indicator (not shown) may be located over the device or at least over the rotating first section of the device to indicate whether the device had been used.

(31) The device is preferably formed a plastic material and may be formed by machining the body and plunger assemblies and then applying the necessary seals and the like, or preferably by molding the body and the plunger separately and assembling them together with the necessary seals and other components. Alternatively, the body may be molded into two separate halves and assembled by attaching the plunger component with the necessary seals and other components to one half of the body, followed by the attaching the remaining half of the body to the plunger, necessary seals, other components, and the first half of the body.

(32) The device may be made of any plastic material capable of withstanding in line steam sterilization. The temperature and pressure of such sterilization is typically about 121 C. and 1 bar above atmospheric pressure. In some instances, it may be desirable to use even harsher conditions such as 142 C. and up to 3 bar above atmospheric pressure. The body and at least the face of the plunger should be capable of withstanding these conditions. Preferably, the entire device is made of the same material and is capable of withstanding these conditions. Suitable materials for this device include but are not limited to PEI (polyetherimide), PEEK, PEK, polysulphones, polyarlysulphones, polyalkoxysulphones, polyethersulphones, polyphenyleneoxide, polyphenylenesulphide and blends thereof. Alternatively, one can make the face portion from ceramic or metal inserts alone, or that are overmolded with a plastic cover. One can also form a polymeric face with a metal outer layer using plasma coating processes.

(33) The seals of the present invention can be made of a variety of materials typically used for making resilient seals. These materials include but are not limited to natural rubber, synthetic rubbers, such as silicone rubbers, including room temperature vulcanizable silicone rubbers, catalyzed (such as by platinum catalysts) silicone rubbers and the like, thermoplastic elastomers such as SANTOPRENE elastomers, polyolefins such as polyethylene or polypropylene, especially those containing gas bubbles introduced either by a blowing agent or entrained gas such as carbon dioxide, PTFE resin, thermoplastic perfluoropolymer resins such as PFA and MFA resins available from Ausimont, USA Inc., of Thorofare, N.J. and E.I. DuPont de Nemours of Wilmington, Del., urethanes, especially closed cell foam urethanes, KYNAR PVDF resin, VITON elastomer, EPDM rubber, KALREZ resin and blends of the above.

(34) Suitable materials for molded in place seals can be curable rubbers, such as room temperature vulcanizable silicone rubbers, thermoplastic elastomers such as SANTOPRENE elastomers, polyolefins such as polyethylene or polypropylene, especially those containing gas bubbles introduced either by a blowing agent or entrained gas such as carbon dioxide and elastomeric fluoropolymers.

(35) Other materials used in the devices should also be FDA grade components such as FDA grade silicones, PTFE resins and the like.

(36) The present invention provides a sterile and steam sterilizable in place connecting device for fluid transfer. It may be single actuation (one open one close) or it may be multiple actuations with a single sterile connection (multiple openings and closings) so long as the sterile connection upstream and downstream is maintained. Additionally, with the use of multiple seals or seals of long length, one is able to ensure that the sterility of the device is maintained even with multiple actuations.

(37) Many modifications and variations of this invention can be made without departing from its spirit and scope, as will be apparent to those skilled in the art. The specific embodiments described herein are offered by way of example only and are not meant to be limiting in any way. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the invention being indicated by the following claims.