Abstract
A holding structure for holding a plurality of containers for pharmaceutical, medical or cosmetic purposes includes a carrier having openings or receptacles for accommodating the containers. Holding devices for holding the containers are provided at the openings or receptacles. The holding devices can selectively assume two different stable positions, namely a first stable position in which the containers can be inserted without friction into the openings or receptacles and a second stable position in which the containers are held in the respective opening or receptacle by frictional engagement or by positive locking. The containers can be reliably inserted into the openings or receptacles without material abrasion. In the open insertion position of the holding devices, a large number of containers can be inserted concurrently into the openings or receptacles without high forces acting on the holding structure.
Claims
1. A combination, comprising: a transport or packaging container that is box-shaped; a plurality of containers for substances for pharmaceutical, medical or cosmetic applications, the containers being cylindrical and open at least at one end; and a holding structure accommodated in the box-shaped transport or packaging container and concurrently holding the plurality of containers, the holding structure comprising: a planar carrier having a plurality of openings or receptacles that are formed and arranged in a regular arrangement and are each holding a respective one of the containers; and at least two holding devices assigned to each of the openings or receptacles for holding the plurality of containers on the carrier by frictional engagement or by positive locking; the holding devices being configured to selectively assume two different stable positions, wherein, in a first stable position, the distance between the holding devices is sufficiently large so that in the first stable position of the holding devices the containers can be inserted into or removed from a respective opening or receptacle, and, in a second stable position of the holding devices, the distance between the holding devices is sufficiently small so that in the second stable position the containers are held by the holding devices in the respective opening or receptacle by frictional engagement or by positive locking.
2. The combination of claim 1, wherein the holding devices are configured to be bi-stable and are elastically biased into the first stable position and into the second stable position which is different from the first stable position, in order to be able to selectively assume the first stable position or the second stable position.
3. The combination of claim 1, further comprising an actuating element connected to the holding devices by film hinges, wherein in the first stable position the film hinges press the holding devices apart by an elastic restoring force, wherein the film hinges are configured to be pressed over by actuating the actuating element for transferring the holding devices into the second stable position.
4. The combination of claim 3, wherein the holding devices are each pivotably connected to the actuating element by a first hinge and are each connected to the carrier by a second hinge, so that the holding devices are transferred from the first stable position into the second stable position by adjusting the actuating element relative to the carrier.
5. The combination of claim 4, wherein the actuating element is formed and arranged to be adjustable in a radial direction of the respective opening or receptacle and within a plane spanned by the carrier for transferring the holding devices from the first stable position into the second stable position.
6. The combination of claim 5, wherein the actuating element comprises a base body having a projection projecting radially therefrom and two holding arms connected to the base body that are moved towards one another from the first stable position and transferred into the second stable position by radial adjustment of the base body, wherein a gap is formed between the base body and an edge of the respective opening or receptacle both in the first stable position and in the second stable position.
7. The combination of claim 6, wherein the actuating element is mirror-symmetrical and the holding arms are arranged in the respective opening or receptacle mirror-symmetrically with respect to the actuating element.
8. The combination of claim 6, wherein the projection projects radially from the base body to such an extent that in the second stable position the projection directly abuts a cylindrical side wall or a constricted neck portion of a respective container so that the projection acts as a control cam for controlling the position of the holding arms.
9. The combination of claim 5, wherein the actuating element comprises a base body having a projection projecting radially therefrom and two holding arms connected to the base body that are moved towards one another from the first stable position and transferred into the second stable position by radial adjustment of the base body, the holding arms being concavely curved in sections and having a radius of curvature which is matched to a radius of a respective container in a region of a cylindrical side wall or of a constricted neck portion.
10. The combination of claim 5, wherein, in the second stable position, the holding devices are elastically biased against each other by an elastic restoring force exerted by the hinges, wherein the hinges are configured be pressed over by displacement of the respective container in a direction perpendicular to the direction of extension of the projection for transferring the holding devices back to the first stable position.
11. The combination of claim 5, wherein the actuating element, the holding devices and the hinges are formed integrally with the carrier.
12. The combination of claim 1, wherein the holding devices are formed as holding arms projecting from the carrier and holding the containers in the second stable position clamped in a region of a cylindrical side wall or of a constricted neck portion or engaging behind a widened upper rim in order to hold the containers axially secured on the carrier.
13. The combination of claim 1, further comprising an actuating element connected to the holding devices by a first hinge and a second hinge, the actuating element being formed and arranged so as to be adjustable in the respective opening or receptacle perpendicular to a plane spanned by the carrier for transferring the holding devices from the first stable position into the second stable position.
14. The combination of claim 13, wherein the actuating element is formed as a cylindrical body having a closed top, wherein an annular gap, which is bridged by the first hinge, by a portion of the holding devices and by the second hinge, is formed between an edge of the respective opening or receptacle and the actuating element.
15. The combination of claim 14, wherein the cylindrical body is centered with respect to an axis of symmetry of the respective opening or receptacle of the carrier.
16. The combination of claim 13, wherein the holding devices are formed as holding arms having holding claws, a length of the holding arms being matched to an axial length of the containers in such a manner that, in the second stable position, the containers are held clamped at an upper end of a cylindrical side wall or at a constricted neck portion or that a widened upper rim is engaged behind, for holding the containers axially secured to the carrier.
17. The combination of claim 1, wherein the carrier includes a side wall provided at least in sections on a rear side of the carrier along an edge of the respective opening or receptacle, for preventing a collision of containers which are accommodated in directly adjacent openings or receptacles of the carrier.
18. The combination of claim 1, wherein the plurality of openings or receptacles comprises at least three openings or receptacles.
Description
BRIEF DESCRIPTION OF THE DRAWINGS
(1) The above-mentioned and other features and advantages of this invention, and the manner of attaining them, will become more apparent and the invention will be better understood by reference to the following description of embodiments of the invention taken in conjunction with the accompanying drawings, wherein:
(2) FIGS. 1A-1H show a detail of an exemplary embodiment of a subunit of a holding structure provided according to the present invention in different stages of insertion, holding and removal of a vial, each in a plan view and in a partial perspective view;
(3) FIG. 1I shows in a perspective plan view an exemplary embodiment of a holding structure provided according to the present invention;
(4) FIG. 1J shows in a perspective representation and in a partial section, a transport and packaging container comprising the holding structure illustrated in FIG. 1I and containers held thereon;
(5) FIGS. 2A-2B show a detail of another exemplary embodiment of a holding structure provided according to the present invention in an open insertion position and in a closed holding position;
(6) FIGS. 3A-3N show a detail of another exemplary embodiment of a holding structure provided according to the present invention in different stages of insertion and holding of a vial;
(7) FIG. 3O shows in a perspective plan view the holding structure illustrated in FIGS. 3A-3N;
(8) FIG. 3P shows in a perspective representation and in a partial detail a transport and packaging container with the holding structure illustrated in FIGS. 3A-3O and containers held thereon;
(9) FIGS. 4A-4F show a detail of another exemplary embodiment of a holding structure provided according to the present invention at different stages of insertion and holding of a vial;
(10) FIG. 4G shows in a perspective top view the holding structure illustrated in FIGS. 4A-4F;
(11) FIG. 4H shows in a perspective representation and in a partial detail a transport and packaging container with the holding structure illustrated in FIGS. 4A-4G and containers held thereon;
(12) FIGS. 5A-5C show in schematic sectional views of three stages of inserting and holding a vial between pivotally supported holding arms for explaining an exemplary embodiment provided according to the present invention;
(13) FIG. 5D shows in an overall view the pivotally supported holding arms in the two extreme positions illustrated in FIGS. 5B and 5C;
(14) FIGS. 6A-6B show a section of an exemplary embodiment of a holding structure provided according to the present invention, comprising pivotally movable, bi-stably supported holding arms, and a strongly enlarged representation thereof;
(15) FIG. 6C shows in a perspective top view the holding structure illustrated in FIGS. 6A-6B;
(16) FIG. 6D shows in a perspective representation and in a partial section, a transport and packaging container with the holding structure illustrated in FIGS. 6A-6C and containers held thereon;
(17) FIG. 7A shows in a partial perspective representation, a known transport and packaging container with a holding structure; and
(18) FIG. 7B shows in an enlarged partial section the known holding structure illustrated in FIG. 7A with a vial held on it.
(19) Corresponding reference characters indicate corresponding parts throughout the several views. The exemplifications set out herein illustrate embodiments of the invention and such exemplifications are not to be construed as limiting the scope of the invention in any manner.
DETAILED DESCRIPTION OF THE INVENTION
(20) FIGS. 1A-1H show a schematic detail of an exemplary embodiment of a holding structure provided according to the present invention in different stages of insertion, holding and removal of a vial, each in a plan view and in a partial perspective view. For reasons of simplification, only one subunit 11 of the holding structure is shown in the drawings, consisting of a central opening 12 and six openings 13 surrounding it, each of which is surrounded by a peripheral web 12, which forms the actual holding structure. Further details of holding of the vials 1 are shown for reasons of simplification only for the central opening 13. However, the remaining openings of the holding structure are also configured correspondingly.
(21) According to FIG. 1A, two curved holding arms 26, 27 are each pivotally and movably supported in opening 13. To be more precise, the holding arms 26, 27 are supported on a base body 21 so that they can be displaced or adjusted, which base body is of mirror-symmetrical design and has a central projection 25 radially protruding into opening 13. The holding arms 26, 27 are connected to the base body 21 by first film hinges 23a. Furthermore, the holding arms 26, 27 are connected by second film hinges 23b to the holding bar 12 at the edge of the opening 13 so that they can be flapped or pivoted. The film hinges 23a, 23b are formed as elastic, flexible webs of relatively small thickness and are warped and deformed in each of the two stable end positions of the holding arms 26, 27 in order to secure the respective end position by elastic biasing. In the open insertion position of the holding arms 26, 27, shown in FIG. 1A, the distance between the holding arms 26, 27 is sufficiently large so that the containers 1 can be inserted into or removed from the respective opening 13. In the first insertion position, the film hinges 23a, 23b push the holding arms 26, 27 apart by an elastic restoring force, so that the insertion position shown in the drawing represents a stable end position of the holding arms 26, 27. As shown in the corresponding perspective view of FIG. 1B, the vial 1 is inserted from above by lowering into opening 13.
(22) As shown in FIGS. 1C and 1D, in the open insertion position of the holding arms 26, 27, the vial 1 is lowered further into opening 13 until the constricted neck portion 5 of vial 1 has finally reached the level of the projection 25, as shown in FIG. 1D.
(23) In this position the vial 1 is now displaced radially outwards in the direction of the projection 25 until the constricted neck portion 5 comes in contact with the projection 25 and adjusts this further radially outwards towards the edge of the opening 13. Here, the base body 21 is carried along and the film hinges 23a, 23b are actuated in order to transfer the holding arms 26, 27 from the open insertion position (first stable end position of the holding arms 26, 27) into the closed holding position (second stable end position of the holding arms 26, 27), in which the constricted neck portion 5 of the vial 1 is clamped by the holding arms 26, 27 and the widened upper rim 6 of the vial 1 can also be positively engaged behind by the holding arms 26, 27, whereby the vial 1 is held axially secured by friction or positive locking in the receptacle 13 of the holding structure. This closed holding position is shown in FIGS. 1E and 1F. According to FIG. 1E, even in the closed holding position there is a gap 24 between the base body 21 and the edge of the opening 13, which does not impede the displacement of the base body 21. In principle, by engaging a control cam in this gap and by adjusting the control cam, the base body may also be displaced in the reverse direction and the holding arms 26, 27 pressed apart back into the open insertion position. According to FIG. 1A, the edge of the opening 13 does not impede the position of the holding arms 26, 27 may be in the open insertion position. For changing into the other stable end position, the elastic restoring force exerted by the film hinges 23a, 23b must be overcome, which is achieved by overpressing by radially adjusting the projection 25 of the base body 21, which acts as an actuating element.
(24) For changing back from the closed holding position as shown in FIG. 1E into the open holding position, the vial 1 is displaced radially outwards and away from the projection 25 to pivot one of the holding arms 26, 27 outwards relative to the base body 21 until the elastic restoring force exerted by the film hinges 23a, 23b, which secures the closed holding position, is overcome so that the holding arms 26, 27 then return to the open insertion position. In this open insertion position, the vial 1 can be removed from opening 13 vertically upwards without friction.
(25) FIG. 1I shows a specific example of a holding structure 110 using the principle described above in FIGS. 1A-1A. According to FIG. 1I, the holding structure 110 is formed by a planar carrier 110a, in which the openings 111 are arranged in a regular arrangement. A circumferential side wall 113 extends along the edge of the carrier 110a and perpendicular to the carrier 110a. The carrier 110a can be gripped and handled via access openings 115 by a gripper or robot. On the underside of the carrier 110a, the openings 111 are limited by side walls 112, which are formed circumferential. Holding devices are provided in the openings 111, the operation of which has been described above with reference to FIGS. 1A-1H. The holding structure may be made of plastic material, for example by injection molding or 3D printing.
(26) A plurality of projections 120 and recesses 125 are formed alternately and at regular intervals to each other along the two longitudinal sides of the carrier 110a. These have an overall triangular or polyhedral base area if viewed from above and are formed corresponding to each other so that the projections 120 and recesses 125 of such a holding structure 110 can be hooked in the manner of a dovetail joint directly with projections and recesses of a holding structure (not shown) of a similar configuration. Along the edges 121, 122 of the projections 120 and along the edges 126, 127 of the recesses 125, the upright side wall 113 of the carrier 110a follows the contour of the associated projection 120 and of the associated recess 125, respectively, whereby sliding of a carrier 110a over or onto another carrier 110a of the same design (not shown) can be prevented when two carriers are hooked together.
(27) A transport and packaging container (also referred to as a ‘tub’) as shown in FIG. 1J may be used to accommodate such a holding structure 110 (also referred to as a ‘nest’) with or without containers held thereon. According to FIG. 1J, the transport and packaging container 100 is substantially box-shaped or trough-shaped and has a closed bottom 101, a circumferential side wall 102 projecting perpendicularly therefrom, a step 103 projecting substantially at a right angle therefrom, a circumferential upper side wall 104 and an upper rim 105 which is formed like a flange. The corners 106 of the transport and packaging container 100 are appropriately rounded. The top sidewall 104 may be inclined at a slight angle relative to a line perpendicular to the bottom 101 to facilitate insertion of the holding structure 110. Such a transport and packaging container 100 may be made of a clear, transparent plastic material, in particular by plastic injection molding or 3D printing, in order to enable an optical visual inspection of the holding structure 110 accommodated in the transport and packaging container 100 and of the containers 1 held by it.
(28) In principle, also the lower end of the transport and packaging container 100 may be open in the manner of the upper end, in particular it may be provided with a flange-like lower edge in the manner of the upper rim 105, so that the bottoms of the vials 120 are freely accessible from the underside of the transport and packaging container 100, for example for processing steps carried out in a sterile tunnel or in a freezer-dryer.
(29) For the transport or storage of the containers 1, the transport or packaging container 100 is closed by a protective film or packaging film (not shown) adhered to the upper rim 105, for example by a gas-permeable plastic film, in particular by a TYVEK® protective film, which enables sterilization of the containers 1 held by the holding structure 110 also through the protective film.
(30) Referring to FIGS. 2A and 2B, another exemplary embodiment according to the present invention is illustrated. In these drawings again only a subunit 11 of the holding structure is shown, which may be incorporated in the holding structure 110 of FIG. 1I in place of the subunit 11 illustrated in FIGS. 1A-1H, wherein the vial to be held is not shown for reasons of simplification. According to FIG. 2A, an additional layer 60 of an elastic, flexible plastic material is injected in the region of opening 13 onto the peripheral web 12 of the holding structure using a two-component injection molding technology (2K injection molding technology), which is made of a plastic material and forms an actuating element 61 and a plurality of holding arms 70. According to FIG. 2A, the actuating element 61 is formed as a cylindrical body having a closed top surface 62, wherein an annular gap 65 is formed between an edge of the respective opening 13 of the holding structure and the actuating element 61, which is bridged by the first film hinge 73, by a portion 72 of the holding arms 70 and by a second film hinge 68. The actuating element 61 is configured and arranged in such a manner that it can be adjusted in the respective opening 13 perpendicularly to a plane spanned by the holding structure, i.e. in a direction parallel to the axis of symmetry 80. The holding arms 70 are each pivotably connected to the actuating element 61 by a first film hinge 73 and are each connected to the carrier 11 by a second film hinge 68, so that the holding arms 70 can be transferred from the first stable end position of the holding arms 70 into the second stable end position of the holding arms 70 by adjusting the actuating element 61 perpendicularly to the holding structure.
(31) FIG. 2A shows the closed holding position of the holding arms 70, in which the holding claws 71 at their front free ends either clamp the vial (not shown) or hold it axially secured by a positive locking, in particular by engaging behind a widened upper rim of the vial. For this purpose, the holding claws 71 may also project further radially inwards into the opening 13.
(32) According to FIG. 2A, the first film hinge 73 is configured to be circumferential, but this is not absolutely necessary. In this manner the entire opening 13 is closed. The position of the upper side 62 of the actuating element 61 is only schematically shown. The actuating element 61 may also be arranged far below the peripheral web 12 in order to enable the vials to be accommodated in the openings of the holding structure.
(33) FIG. 2B shows the open holding position of the holding arms 70, in which the holding claws 71 are spread apart to such an extent that a container can be inserted into or removed from the respective opening 13. As one can easily conclude from a comparison of the drawings, there is a clear height offset of the actuating element 61 between the two end positions, which corresponds to the movement path of the holding arms 70 during their pivoting movement.
(34) FIGS. 3A-3N show a section of a holding structure according to another exemplary embodiment provided according to the present invention in different stages of insertion and holding of a vial.
(35) According to FIG. 3A, diametrically opposite holding devices are provided at the edge of the openings 13, which are each formed by two C-shaped holding arms 34, 35 and each form a semi-circular receptacle. The holding arms 34, 35 are elastically biased into the insertion position shown in FIG. 3A by film hinges 32. In the insertion position, the distance between the holding arms 34, 35 is sufficiently large so that a container can be inserted vertically from above or below into the opening 13 of the holding structure and into the receptacle formed by the two pairs of holding arms 34, 35, or removed from it again. The holding arms 34, 35 are pivotally supported on the peripheral webs 12 of the holding structure 11 and can be pivoted down to the closed holding position shown in FIG. 3M. In the closed holding position, the distance between the holding arms 34, 35 is sufficiently small so that the containers are held in the respective opening 13 of the holding structure 11 and in the circular receptacle formed by both pairs of holding arms 34, 35 by friction or positive locking. More specifically, the holding arms 34, 35 are configured to hold the containers clamped in the region of a cylindrical side wall or of a constricted neck portion or to engage positively behind a widened upper rim to hold the containers axially secured on the holding structure.
(36) According to FIG. 3A, the two holding arms 34, 35 are connected to each other by a web-shaped base 31. At the base 31 a projection 36 is formed between the two holding arms 34, 35, which projects in the radial direction to such an extent that, in the closed holding position, the projection 36 abuts directly against the cylindrical side wall or against the constricted neck portion of the respective container or engages behind a widened upper rim of the respective container. The projection 36 thus serves as an additional holding device, but also controls a centered positioning of the containers in the openings 13 of the holding structure 11 in the closed holding position of the holding arms 34, 35.
(37) According to FIG. 3A, elastic portions 39, 40 are formed at the front free ends of the holding arms 34, 35, which are in particular made of relatively thin plastic portions. The elastic portions 39, 40 touch each other directly in the closed holding position (see FIG. 3M) under elastic deformation of these portions 39, 40, so that the holding arms 34, 35 are elastically biased against each other in the closed holding position and thus the closed holding position of the holding arms 34, 35 is secured against accidental release of the containers.
(38) According to FIG. 3A, block-shaped stops 33 are formed at the rear ends of the holding arms 34, 35 on their underside, which cooperate with the edge of the respective opening or receptacle 13 of the holding structure in the closed holding position of the holding arms 34, 35 in order to prevent further pressing down of the holding arms 34, 35 and thus to limit the closed holding position of the holding arms 34, 35. To be more precise, the shape of the elastic portions 39, 40 allows a downward force component to be generated in the closed holding position, which acts on the holding arms 34, 35 and causes the holding arms 34, 35 to be permanently pressed downwards even in the closed holding position, this elastic biasing force acting against the stops 33 at the rear ends of the holding arms 34, 35. Thus, in the closed holding position, the holding arms 34, 35 assume a stable end position from which the holding arms 34, 35 can only be returned to the other end position (the open insertion position) by applying a predetermined minimum force which exceeds a certain threshold value which is sufficiently higher than the forces normally occurring during further processing of the containers due to displacement or handling (raising, lowering, rotating, tilting, vibrating) of the holding structure. An accidental adjustment of the holding arms 34, 35 from the closed holding position into the open insertion position can thus be reliably eliminated.
(39) For controlling the position of the holding arms 34, 35 and pivoting the holding arms 34, 35 in a coordinated manner into the closed holding position, an external actuating device is used, as shown schematically in FIG. 3B. This actuating device has a total of four triangular projections 46 provided on actuating rods 45 which are vertically adjustable relative to the holding structure 11, the distance between the projections 46 being matched to the distance between the holding arms 34, 35 of a respective opening 13 of the holding structure 11. When the actuating device is adjusted perpendicular to the holding structure, the inner bevels of the projections 46 first come in contact with the outer sides of the holding arms 34, 35 as shown in FIG. 3C. When the actuating device is lowered further, these bevels slide along the outer sides of the holding arms 34, 35 and thus swing or pivot the holding arms 34, 35 gradually towards the peripheral webs 12 of the holding structure 11, as can be seen from the sequence of FIGS. 3C to 3G. Finally the condition according to FIG. 3H is reached in which the widened upper rim 6 of the container 1 rests directly on the rounded portions 37, 38 at the front free ends of the holding arms 34, 35.
(40) In this position the actuating device can now be removed, as shown in FIG. 3H. In this position, the self weight of the containers 1 may be sufficient to pivot the holding arms 34, 35 further downwards towards the peripheral webs 12 of the holding structure 11. Or the containers 1 are pressed further down towards the holding structure, for example by a plate (not shown). When the containers 1 are pressed down, the holding arms 34, 35 are carried along and thus swiveled further downwards towards the holding structure 11. This further adjustment of the holding arms 34, 35 towards the closed holding position is shown in the sequence of FIGS. 3H to 31. The widened upper rim 6 of the container 1 slides along the rounded portions 37, 38 at the front free ends of the holding arms 34, 35 until finally the closed holding position according to FIG. 3M is reached, in which the widened upper rim 6 of the container 1 rests both on the holding arms 34, 35 and on the radial projection 36. This closed holding position is shown in a greatly enlarged view in FIG. 3N.
(41) To release the containers 1 from the closed holding position, the containers 1 simply need to be adjusted vertically upwards and perpendicular to the holding structure 11, for example by pressing the bottoms 3 of container 1 upwards, for example by a plate. The holding arms 34, 35 are automatically swiveled upwards from the neck portions of the containers. After removing the containers 1 vertically upwards from the openings 13 of the holding structure 11, the holding arms 34, 35 are again automatically biased elastically into the open insertion position according to FIG. 3A by the restoring force exerted by the film hinges 32.
(42) FIG. 3O shows a specific example of a holding structure 110 configured according to the operation described with reference to FIGS. 3A-3N. FIG. 3P shows in a perspective partial sectional view a transport and packaging container 100 together with such a holding structure 110 accommodated in it.
(43) FIGS. 4A-4F show a section of an exemplary embodiment of a holding structure 11 provided according to the present invention at different stages of insertion and holding of a vial. According to FIG. 4A, the holding devices are formed as pairs of foldable or collapsible holding plates 93 which lie diametrically opposite one another at the edge of the respective opening or receptacle 13 of the holding structure 11, wherein portions of the holding plates 93 folded or clapped inwardly clamp the containers 1, in the closed holding position (cf. FIG. 4F), in the region of a cylindrical side wall 2 or of a constricted neck portion 5 or engage behind a widened upper rim 6 in a positive-locking manner in order to secure the containers 1 axially to the holding structure 11. According to FIG. 4A, material weakening regions 94 are formed at the centre of the holding plates 93, which serve as folding lines and along which the holding plates 93 can be folded or collapsed.
(44) For actuating the holding plates 93, an intermediate plate 90 is further provided, which is initially arranged at a distance from the holding structure 11, has a plurality of openings 92 corresponding to the openings or receptacles 13 of the holding structure 11 and is adjusted towards the holding structure 11 by being pressed down in order to transfer the holding plates 93 in a coordinated manner from the open insertion position into the closed holding position and/or from the closed holding position into the open insertion position. Conveniently, the intermediate plate 90 is formed separately from the holding structure 11 and can be adjusted or displaced relative to it.
(45) According to FIG. 4B, for insertion into the openings of the carrier 110a the widened upper rims 6 of the containers 1 rest on the rods 45 of an external control device used to control the position of the holding devices of the holding structure 11. By lowering the actuating device or the rods 45, the lower ends of the containers 1 are finally inserted into the openings of the intermediate plate 90 and into the openings formed by the holding plates 93 of the carrier 110a, as shown in FIG. 4C. As the rods 45 are lowered further, the front ends of the triangular projections 46 of the actuating device, which act as control cams, finally come in contact with the intermediate plate 90. As the actuating device and rods 45 are lowered further, the containers 1 are inserted further into the openings of the carrier 110a and at the same time the intermediate plate 90 is moved vertically towards the carrier 110a. The pressure exerted by the intermediate plate 90 on the holding plates 93 results in an elastic deformation of the holding plates 93, namely in a folding along the folding lines 94, as shown in FIG. 4F. Finally the containers 1 are held on the holding structure as shown in FIG. 4F. The self weight of the containers 1 and the weight of the intermediate plate 90 may be sufficient to elastically bias the holding plates 93 to a sufficient extent into the closed holding position.
(46) To release and remove the containers 1 from the closed holding position, the containers 1 simply need to be adjusted vertically upwards, perpendicular to the carrier 110a, for example by pushing the bottoms 3 of the containers 1 upwards, for example by a plate, or also by the aforementioned actuating device. The holding plates 93 are automatically swiveled upwards. After removing the containers 1 vertically upwards from the openings 13 of the carrier 110a, the holding plates 93 are automatically elastically biased back into the open insertion position according to FIG. 4A by the restoring force exerted by the material weakening portions 94, which act as film hinges.
(47) FIG. 4G shows a specific example of a holding structure 110 configured according to the operation described with reference to FIGS. 4A-4F. FIG. 4H shows in a perspective partial section a transport and packaging container 100 together with such a holding structure 110 accommodated in it.
(48) FIGS. 5A-5C show three stages of inserting and holding a vial 3 between holding arms 50, which are pivotally mounted on a holding structure, in order to explain an exemplary embodiment provided according to the present invention in schematic sectional views. According to FIG. 5A, a plurality of holding arms 50 is arranged at the edge of a respective opening of the holding structure, such as at uniform angular distances from each other. While FIG. 5A shows two holding arms 50 arranged diametrically opposite each other, three holding arms (to achieve a three-point support of the containers) or more holding arms are also possible. The holding arms 50 are pivotally mounted on the holding structure, which can be achieved by a suitable integral design of the holding arms 50 with the holding structure, for example in the form of integral rotary axes 51 acting as torsion springs and produced by a plastic injection molding process, or by torsion springs made of metal or plastic. The holding arms are thus permanently biased by an elastic restoring force into a stable end position, such as into a closed holding position, as shown below, or alternatively into an open insertion position, as shown in FIG. 5A, in which the containers 1 can be inserted vertically from above into the gap or the receptacle between the holding arms 50 without friction.
(49) The holding arms 50 each have a front free end 52, on which a holding claw 54 is formed, on which a supporting nose 55 is formed projecting radially inward. In the closed holding position with the front ends 52 of the holding arms 50 swiveled radially inwards (see FIG. 5C), the plurality of supporting noses 55 is arranged at the same distance with respect to the holding structure so that the supporting noses 55 together span a plane. In the closed holding position of the holding arms 50, the widened upper rims 6 of the containers 1 rest on these supporting noses 55, so that the containers 1 are axially secured to the holding structure by positive locking with the supporting noses 55. At the front free ends 52 of the holding arms 50 bevels 56 are formed which allow the widened upper rim not to be clamped by portions of the holding claw 54 above the respective supporting nose 55 even in the inwardly pivoted holding position of the holding arms 50 when the holding arms 50 are inclined inwardly with respect to a perpendicular bisector onto the opening of the holding structure, which further avoids undesirable friction effects during removal or insertion of the containers 1 into the openings of the holding structure.
(50) According to FIG. 5A, the rear free ends 53 of the holding arms 50 are arranged in relation to the axis of rotation 51 on the opposite side of the front free ends 52. When the holding arms 50 are swiveled around the rotary axes 51, the front and rear ends 52, 53 of the holding arms 50 are thus moved in opposite directions.
(51) The holding arms 50 are pivoted by a control device, not shown here, which acts, for example in the manner of a control cam, on the rear free ends 53 of the holding arms 50 in order to move them together in a coordinated manner radially inwards or outwards and thus to adjust the front free ends 52 of the holding arms 50 in opposite directions. The actuating device may, for example, be formed as a plate having a plurality of conical recesses aligned with the apertures of the holding structure and whose diameter at its upper end corresponds to the distance between the rear free ends 53 of the holding arms 50 in the closed holding position of the holding arms 50 and whose diameter at its lower end corresponds to the distance between the rear free ends 53 of the holding arms 50 in the open insertion position of the holding arms 50. If such an actuating device is now moved vertically upwards from below in the direction of the holding structure, the rear free ends of the holding arms 50 first come in contact with the upper rim of these conical recesses. As the actuating device continues to move vertically upwards towards the holding structure, the rear free ends 53 of the holding arms 50 slide along the side wall of the conical recesses of the actuating device and are adjusted radially inwards, causing the front free ends 52 of the holding arms 50 to pivot gradually radially outwards. Finally, the open insertion position of the holding arms 50 shown in FIG. 5A is reached, in which the distance between the supporting noses 55 of the holding arms 50 is greater than the maximum outer diameter of the containers 1.
(52) In this open insertion position of the holding arms 50, the containers 1 can be inserted from above into the openings of the holding structure as well as into the space between the holding arms 50 without friction. FIG. 5B shows the containers 1 in a position in which the containers 1 are inserted vertically into the openings of the holding structure to such an extent that the underside of the widened upper rim 6 of the containers 1 is at the height of the supporting noses 55 of the holding arms 50.
(53) If in this position of the holding arms the actuating device is now moved in the opposite direction, i.e. vertically downwards and away from the holding structure, the holding arms 50, controlled by the cooperation of the rear free ends 53 of the holding arms 50 with the inner wall of the conical recesses of the actuating device, are moved in the opposite direction, i.e. radially outwards, which requires a corresponding coordinated, synchronous pivoting of the holding arms 50 around the axes of rotation 51 radially inwards. When further adjusting the actuating device, the closed holding position of the holding arms 50 shown in FIG. 5C is finally reached, in which the widened upper rim 6 of the containers 1 rests on the supporting noses 55 at the front free ends 52 of the holding arms 50 and in which the constricted neck portion 5 of the containers 1 is clamped by the front ends of the supporting noses 55.
(54) In order to prevent the containers 1 from falling uncontrollably into the openings of the holding structure, the containers 1 need to be held or supported during their insertion into the openings of the holding structure and during their removal therefrom, which can be achieved, for example, from above the holding structure by grippers or robot arms of a process equipment or from below the holding structure by cylindrical projections or by the bottoms of the aforementioned conical recesses of the actuating device, on which the bottoms 3 of the containers 1 are temporarily supported and which are aligned with the openings of the holding structure. The cylindrical projections may also be formed within the abovementioned conical recesses of the actuating device.
(55) Alternative actuating devices can also be used which enable a coordinated, synchronous adjustment of the holding arms 50 in an appropriate manner, such as a simultaneous synchronous adjustment of all holding arms 50 of the holding structure. This coordinated adjustment may be controlled in an appropriate manner by control cams or the like which cooperate mechanically with the rear or front ends 53, 52 of the holding arms 50 or with other portions of the holding arms 50 to effect their synchronous adjustment. Mechanical adjustment devices, such as grippers or robot arms, can also be used to act on portions of the holding arms 50, in particular the rear or front ends 53, 52 of the holding arms 50, in such a way that the holding arms 50 are adjusted synchronously and in a coordinated manner.
(56) FIG. 5D shows an overall view of the pivotally mounted holding arms 50 in the two extreme positions of FIGS. 5B and 5C, namely in the open insertion position (reference numeral without apostrophe) and in the closed holding position (reference numeral with apostrophe).
(57) FIG. 6A shows a section of an embodiment of a holding structure provided according to the present invention, having pivotable, bi-stable holding arms which are adjusted according to the operation described above with reference to FIGS. 5A-5C. In this embodiment, the holding arms 50 are pivotally mounted on the inside of the side walls 14 of the openings 13 of the holding structure 11. The front free ends 52 of the holding arms 50 project from the plane spanned by the peripheral webs 12 of the holding structure, while the rear free ends 53 of the holding arms project beyond the lower edges of the side walls 14 of the holding structure so that these are freely accessible for an external actuating device for adjusting the holding arms 50. FIG. 6B shows a strongly enlarged representation of the embodiment according to FIG. 6A. The rotary axes 51 of the holding arms 50 may be formed in one piece with the lower side walls 14 of the holding structure, for example by a plastic injection molding process. However, the axes of rotation 51 may also be separate from and clipped into the side walls 14 of the holding structure and then, for example, elastically biased into any of the two end positions of the holding arms 50 by an elastic tab on the side wall 14 or by torsion springs or the like.
(58) FIG. 6C shows a specific example of a holding structure 110 configured according to the operation described with reference to FIGS. 6A-6B. FIG. 6D shows in a perspective partial sectional view a transport and packaging container 100 together with such a holding structure 110 accommodated in it.
(59) Another aspect of the present invention relates to a combination of a holding structure, as disclosed above, and a plurality of containers 1 for substances for pharmaceutical, medical or cosmetic applications held thereon, in particular vials or cartridges.
(60) The containers may be inserted and removed from the openings or receptacles of a holding structure even if the holding structure is already accommodated in a transport and packaging container, as described above. The adjustment of the holding devices may also take place in this state, because they can be adjusted between the two stable end positions either directly by the containers themselves or by an external control device having control cams or the like. This does not require access from the underside of the carrier. In the open insertion position of the holding devices, the containers can be inserted into the openings or receptacles practically without friction.
(61) Although exemplary embodiments provided according to the present invention have been explained above with reference to holding structures for holding vials, it should be noted that embodiments provided according to the present invention may also be used in a similar way for any other container for storing substances for pharmaceutical, medical or cosmetic applications, in particular for cartridges or syringes. For this purpose, the containers to be held are conveniently provided with an end having a widened rim, which is followed by a constricted neck portion and a neck portion or container body which has a larger outer dimension (width or outer diameter) than at least the neck portion. Conveniently, such containers are made of glass, but they may also be made of plastic material. Generally, for producing a holding structure in the sense of the present application plastic injection molding techniques are suitable, in particular so-called two-component (2K) injection molding techniques, by which plastics with different properties, in particular of different elasticity, are injection molded. In principle, however, other plastics processing techniques may also be considered, in particular the production using 3D-printers.
(62) While this invention has been described with respect to at least one embodiment, the present invention can be further modified within the spirit and scope of this disclosure. This application is therefore intended to cover any variations, uses, or adaptations of the invention using its general principles. Further, this application is intended to cover such departures from the present disclosure as come within known or customary practice in the art to which this invention pertains and which fall within the limits of the appended claims.
LIST OF REFERENCE NUMERALS
(63) 1 vial/glass bottle 2 cylindrical side wall 3 bottom 4 neck portion 5 constricted neck portion 6 upper rim 7 filling opening 11 subunit of a carrier 12 peripheral web 13 opening/receptacle 14 side wall on the underside of the carrier 20 adjustable element 21 basis 22 connecting web 23a first film hinge 23b second film hinge 24 gap 25 control cam 26 left holding arm 27 right holding arm 30 adjustable element 31 basis 32 film hinge 33 stop 34 left holding arm 35 right holding arm 36 spacer 37 rounding of left holding arm 38 rounding of right holding arm 39 elastic portion of left holding arm 40 elastic portion of right holding arm 41 front end of left holding arm 42 front end of right holding arm 45 rod 46 projection 50 pivotable holding arm 51 axis of rotation with torsion spring 52 front free end of pivotable holding arm 50 53 rear free end of pivotable holding arm 50 54 holding projection 55 supporting nose 56 bevel 60 elastic insert 61 actuating device 62 bottom 63 rear side wall 64 cylindrical cavity 65 lower annular gap 66 circumferential projection 67 step 68 second film hinge 69 circumferential bead 70 clamping lever 71 holding claw 72 connecting web 73 first film hinge 74 upper annular gap 80 symmetry axis 90 pressure plate 91 peripheral web 92 opening 93 adjustable holding element 94 articulated joint 96 access opening 97 projection 98 recess 100 transport and packaging container 101 bottom 102 lower side wall 103 projection 104 upper side wall 105 upper rim 106 rounded corner 110 holding structure 110a carrier 111 opening 112 side wall 113 raised edge 114 rounded corner 115 access opening 120 projection 121 front side wall in the region of projection 120 122 side wall in the region of projection 120 125 recess 126 front side wall in the region of recess 125 127 side wall in the region of recess 125 200 transport and packaging container 201 bottom 202 lower side wall 204 upper side wall 205 upper rim 210 holding structure/carrier 212 holding arm 213 holding projection 214 supporting nose 215 upper bevel 216 lower bevel 220 vial/glass bottle 221 upper rim of vial 220 222 bottom of vial 220 223 side wall of vial 220 224 constricted neck portion of vial 220
