DISPOSABLE FILTRATION DEVICE

Abstract

A disposable filtration device includes a plurality of disposable filter capsules connected with each other by lines, which are carried by a rigid holder. At least the holder and the lines between the filter capsules preferably are formed of a sterilizable material, so that the filtration device can be sterilized in the pre-mounted, i.e. ready-to-connect condition, and can be packed and transported without a risk of damage.

Claims

1. A disposable filtration device, comprising a plurality of disposable filter capsules connected with each other by lines, which are carried by a rigid holder.

2. The disposable filtration device according to claim 1, wherein at least the holder and the lines between the filter capsules are formed of a sterilizable, preferably gamma-sterilizable material.

3. The disposable filtration device according to claim 1, wherein at least the holder and the lines between the filter capsules are made of an autoclavable material.

4. The disposable filtration device according to claim 1, wherein the filter capsules are standing upright in their position of use.

5. The disposable filtration device according to claim 4, further comprising a central air filter for venting the entire unit of filter capsules.

6. The disposable filtration device according to claim 4, further comprising a central collection device for the drainage of the entire unit of filter capsules.

7. The disposable filtration device according to claim 1, further comprising standing feet on which the entire device can stand safely and stably in a predetermined position.

8. The disposable filtration device according to claim 1, wherein the holder protrudes beyond the filter capsules and the lines in all directions.

9. The disposable filtration device according to claim 1, wherein the holder forms a framework for a film wrapping of the device.

10. The disposable filtration device according to any of the claim 1, wherein the holder comprises at least two opposed side walls which are connected with each other by transverse struts, on which holding means for the individual filter capsules are provided.

11. The disposable filtration device according to claim 10, wherein the holding means are provided with elastic materials.

12. The disposable filtration device according to claim 1, wherein at least six filter capsules of a standard size of at least 30 are arranged in a predetermined grid.

13. The disposable filtration device according to claim 1, wherein the filtration device in its entirety defines a measure which is suitable for transport on standard Euro pallets.

14. (canceled)

15. The disposable filtration device according to claim 1, wherein the lines between the filter capsules at least for the most part are formed as rigid conduits.

16. The disposable filtration device according to claim 1, wherein the lines between the filter capsules at least for the most part are formed by several uniform inflow and outflow units.

17. The disposable filtration device according to claim 16, wherein the inflow and outflow units each include an inflow device and an outflow device, which are connected with an end-face inflow and an opposite end-face outflow of an associated filter capsule.

18. The disposable filtration device according to claim 17, wherein the inflow device and the outflow device at least for the most part are identically constructed.

19. The disposable filtration device according to claim 17, wherein the inflow device and the outflow device are connected with each other by a housing wall.

20. The disposable filtration device according to claim 16, wherein the inflow and outflow units are joined to one unit by connection components which are mounted on external connections of the inflow and outflow units.

21. The disposable filtration device according to claim 1, further comprising a sterilizable packaging.

Description

[0031] Further features and advantages of the invention can be taken from the following description and from the attached drawings to which reference is made. In the drawings:

[0032] FIG. 1 shows a perspective view of a first embodiment of the disposable filtration device according to the invention;

[0033] FIG. 2 shows a perspective view of a second embodiment of the disposable filtration device according to the invention;

[0034] FIG. 3 shows a schematic representation of a non-inventive disposable filtration device and an inventive disposable filtration device in a top view;

[0035] FIG. 4 shows a schematic representation of a third embodiment of the disposable filtration device according to the invention without holder; and

[0036] FIG. 5 shows an individual inflow and outflow unit of the third embodiment of the disposable filtration device according to the invention.

[0037] The embodiments of the disposable filtration device 10 as shown in FIGS. 1 and 2 are based on a proven type of disposable filter capsules 12 of the standard size 30 (76.2 cm). In principle, another type of filter capsule can of course also be used. It is also possible to use different types of filter capsules within the same device, as far as this is regarded as expedient. The remaining components of the device in these cases correspondingly are to be adapted to the dimensions of the filter capsules.

[0038] The filter capsules 12 are held in position in a specified arrangement by a rigid holder 14. In the exemplary embodiment shown in FIG. 1, six filter capsules 12 are arranged upright in a 3?2 grid. Other grids with more or less filter capsules 12 are of course also possible, wherein arrangements as compact as possible are preferred. The holder 14 comprises at least two opposed side walls 16 which are connected with each other by transverse struts 18. On the transverse struts 18 holding means 20 for the individual filter capsules 12 are provided. The holding means 20 are provided with elastic materials. Both during the transport and during the operation of the filtration device 10 impact and vibration damping thereby is available for the filter capsules 12.

[0039] The filter capsules 12 are completely or at least for the most part connected with each other by rigid, pressure-stable conduits 22. The course of the conduits 22 is determined by the intended operation of the filtration device (parallel or series connection of the filter capsules 12), wherein the conduits 22 include the necessary branches 24 to the individual filter capsules 12. As far as necessary, the conduits 22 are attached to the holder 14.

[0040] The essential components of the rigid holder 14, the rigid housings of the filter capsules 12 and the rigid conduits 22 all are preferably formed of the same material. This material and possibly further materials which are used in the device 10 (e.g. for possible flexible hose lines) are sterilizable, in particular by means of gamma radiation, and autoclavable after the single use.

[0041] The side walls 16 of the holder 14 are designed such that they protrude beyond the filter capsules 12 and all further critical components. This means that the side walls 16 at least are higher and broader than the entire height or width of the remaining rigid components of the device 10 and that possible flexible components, such as connection tube lines, can be fixed within the volume defined by the side walls 16. It thereby is ensured that during packaging, transport, storage, preparation, post-processing and generally during each handling the device 10 can be placed on a flat surface in every possible position, without there being a risk that protruding parts are damaged or product solution flows out.

[0042] In the exemplary embodiment shown in FIG. 1 the side walls 16 have standing feet 26, on which the entire device 10 can stand safely and stably in a predetermined position. This position corresponds to the operating position in which the filter capsules 12 all are standing upright.

[0043] Furthermore, due to their dimensions the side walls 16 provide for simplified packaging of the device 10 in a film (not shown) which serves as sterility barrier. The device 10 can simply be wrapped with film already in the clean room, or a film bag can be stretched around the side walls 16, wherein it automatically is ensured that no hard or sharp-edged parts of the device can get in contact with the film, as the same all are immovably arranged within the volume defined by the side walls 16 and are immovable.

[0044] The filtration device 10 can be sterilized and packed in the pre-mounted, i.e. ready-to-connect condition. In particular, the entire device 10 can be gamma-sterilized before shipment on one or several Euro pallets with little packaging and cushioning expenditure (only a thin foam pad and a cardboard packaging are necessary), or the entire device 10 is sterilized with hot steam without cardboard and pallet packaging. Storage and disposition can be effected in the completely sterilized condition of the device 10 at the customer or manufacturer, so that the device 10 can be dispatched and be put into operation within a minimum of time. Before and after the single use, only one single integrity test each is necessary, in case such examination is intended.

[0045] FIG. 2 by way of example shows a lying variant of the filtration device 10, wherein some of the conduits 22 have been omitted for better clarity. Here as well, the filter capsules 12 are arranged between side walls 16, which are connected with each other by transverse struts 18. In this variant, no separate standing feet are provided, as the device 10 can stand well on the long sides of the side walls 16. Otherwise, the embodiment of FIG. 2 substantially corresponds to the embodiment of FIG. 1, so that the same advantages apply, in particular with respect to packaging, sterilization and set-up.

[0046] The standing variant of the filtration device as shown by way of example in FIG. 1 however is even more superior to the lying variant with regard to the product recovery after the end of the actual filtration process. In the following, the improved product recovery will be described in more detail with reference to a concrete comparison between a non-inventive filtration device 10 and a filtration device 10 according to the invention.

[0047] FIG. 3 at the top symbolically shows a non-inventive filtration device 10 with six 30 filter capsules 12, which by means of flexible hoses 28 are connected to a closed system. For the application process such device is closed at the inflow and outflow ends and delivered packed in bags and cardboard boxes and sterilized with gamma radiation. To effectively and safely pack the filter capsules 12 connected in parallel by hose lines, to provide for a reasonable handling and in the extreme case a vertical assembly on additional separate holders and to be able to transport and handle the flexible, kinking-sensitive hoses 28 free from damage, a minimum hose length of 1,200 mm must be provided between the individual filter capsules 12. This is necessary in particular to be able to lay the hoses 28 in circles 30 to avoid kinking.

[0048] The addition of the hose lengths only on the outflow side including an outflow hose 32 with a length of 500 mm results in 7,250 mm. At an assumed inside diameter of 1 (25.4 mm) for all hoses 28 this means a calculatory dead volume of 3,674 cm.sup.3, at a likewise still sufficient inside diameter of ? (19.05 mm) still 2,066 cm.sup.3. When the filter capsules 12 are inserted horizontally in the simplest case, it should also be taken into account that the product solution cannot completely be pressed out of the outer housing of the filter capsules 12 through the inner cylindrical membrane filters. In addition, 6?720 cm.sup.3, i.e. altogether 4,320 cm.sup.3, remain in the outer housings.

[0049] For comparison, FIG. 3 at the bottom shows a filtration device 10 constructed according to the invention with likewise six 30 filter capsules 12, which are arranged in a parallel connection. This device surprisingly can do with a tube length on the outflow side of only 790 mm (320 mm+320 mm+150 mm). For technical reasons, however, a larger inside diameter of 38 mm is required, so that on the outflow side a calculatory dead volume of 896 cm.sup.3 is present, plus 253 cm.sup.3 for the drain hose 32 used analogous to the above example with a length of 500 mm and an inside diameter of 1. As the device 10 according to the invention preferably is designed for the advantageous operation with standing filter capsules 12, the amount of 4,320 cm.sup.3 of product solution is not applicable either in this case, which in the case of lying filter capsules 12 would remain in the outer housing.

[0050] Thus, according to this example, a reduction of the product loss by about 86% optimally can be achieved with the device 10 according to the invention (about 1,150 cm.sup.3 as compared to about 8,000 cm.sup.3). Even if the non-inventive device 10 is operated with standing filter capsules 12 and a hose diameter of only ? (19.05 mm), there still is obtained a reduction of the product loss by about 44% (about 1,150 cm.sup.3 as compared to 2,066 cm.sup.3).

[0051] In principle, the conduits 22 need not necessarily have a circular cross-section. Rather, other shapes (e.g. oval) and other sizes than those indicated above also are possible. This also applies for the connections of the embodiment described below.

[0052] FIG. 4 schematically shows another embodiment of the filtration device 10 according to the invention, but without the associated holder 14. The particularity of this embodiment is the tubing of the filter capsules 12. Instead of the conduits 22 and branches 24 rigid, uniform inflow and outflow units 34 of gamma-sterilizable plastic material are provided here. FIG. 5 shows such inflow and outflow unit 34 each separately. For each filter capsule 12 a separate inflow and outflow unit 34 with an inflow device 36 and an outflow device 38 is provided, which are adjusted to the end-face inflow and outflow connections of the respective filter capsule 12. The inflow device 36 and the outflow device 38 are constructed either completely identical or at least largely identical.

[0053] Between the inflow device 36 and the outflow device 38 connecting struts or a housing wall 40 extend, in order to connect the two devices with each other. In the latter case, the filter capsules 12 are surrounded by the completely circumferential housing wall 40 and thereby protected against external influences.

[0054] Both the inflow device 36 and the outflow device 38 each include two opposite external connections 42. By suitable connection components 44, such as TRI clamp connections, several inflow and outflow units 34 can aseptically be connected with each other. An inflow-side external connection 42 of a filter capsule 12 is connected with an inflow-side external connection 42 of an adjacent filter capsule 12. An outflow-side external connection 42 of the one filter capsule 12 likewise is connected with an outflow-side external connection 42 of the adjacent filter capsule 12. In each case, seals are to be provided between the connections. In this way, any number of filter capsules 12 can be joined for a parallel approach flow. The external connections 42 not needed are aseptically sealed by suitable closures 46. These closures 46 or also blind caps likewise are mounted by means of suitable connection components 44.

[0055] The inflow and outflow unit 34 can be formed integrally, as a kit or as prefabricated unit. In particular, several inflow devices 36 and/or outflow devices 38 can be formed integrally or be pre-mounted, before they are mounted on the filter capsules 12.

LIST OF REFERENCE NUMERALS

[0056] 10 disposable filtration device [0057] 12 filter capsule [0058] 14 holder [0059] 16 side wall [0060] 18 transverse strut [0061] 20 holding means [0062] 22 conduit [0063] 24 branch [0064] 26 standing foot [0065] 28 hose [0066] 30 circle [0067] 32 drain hose [0068] 34 inflow and outflow unit [0069] 36 inflow device [0070] 38 outflow device [0071] 40 housing wall [0072] 42 external connection [0073] 44 connection component [0074] 46 closure