MODULATORS OF TNF-ALPHA ACTIVITY

Abstract

Provided herein are inhibitors of TNF?, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the TNF? inhibitory compounds for the treatment of diseases or disorders.

Claims

1.-66. (canceled)

67. A compound of Formula (I), or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof: ##STR00601## wherein, Ring A is selected from ##STR00602## wherein the * denotes point of attachment to L, or an optionally substituted heteroarylene selected from pyrazolene, imidazoline, oxazolene, or thiazolene; V is N or CR.sup.11; W is N or CR.sup.5; X is N or CR.sup.6; Y is N or CR.sup.7; Z is N or CR.sup.8; L is a bond, NH, (CH.sub.2)n-, C(R.sup.12)(R.sup.13), O(CH.sub.2)n-*, or NH(CH.sub.2)n-*, wherein the * denotes point of attachment to phosphorous; n is 1, 2, or 3; R.sup.1 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, or optionally substituted C4-C7 cycloalkylalkyl; R.sup.2 is optionally substituted C1-C3 alkyl; R.sup.3 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; R.sup.4 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; or R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered ring; each R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from hydrogen, halogen, CN, NH.sub.2, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or NH(optionally substituted C1-C3 alkyl); R.sup.9 is selected from hydrogen, or halogen; R.sup.10 is selected from hydrogen, or halogen; R.sup.11 is selected from hydrogen, halogen, or optionally substituted C1-C6 alkyl; and R.sup.12 and R.sup.13 are independently selected from hydrogen, OH, F, and CH.sub.3.

68. The compound of claim 67, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, having the structure of Formula (Ia): ##STR00603## wherein, Ring A is selected from ##STR00604## wherein the * denotes point of attachment to L, or an optionally substituted heteroarylene selected from pyrazolene, imidazoline, oxazolene, or thiazolene; V is N or CR.sup.11; W is N or CR.sup.5; X is N or CR.sup.6; Y is N or CR.sup.7; Z is N or CR.sup.8; L is a bond, NH, (CH.sub.2)n-, O(CH.sub.2)n-*, or NH(CH.sub.2)n-*, wherein the * denotes point of attachment to phosphorous; n is 1, 2, or 3; R.sup.1 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, or optionally substituted C4-C7 cycloalkylalkyl; R.sup.2 is, or optionally substituted C1-C3 alkyl; R.sup.3 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; R.sup.4 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; or R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered ring; each R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from hydrogen, halogen, CN, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or NH(optionally substituted C1-C3 alkyl); R.sup.9 is selected from hydrogen or halogen; R.sup.10 is selected from hydrogen or halogen; and R.sup.11 is selected from hydrogen, halogen, or optionally substituted C1-C6 alkyl.

69. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein ring A is selected from ##STR00605## wherein the * denotes point of attachment to L.

70. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein W is CR.sup.5.

71. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein X is CR.sup.6.

72. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein Y is CR.sup.7.

73. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein Z is CR.sup.8.

74. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein W is CR.sup.5, X is CR.sup.6, Y is CR.sup.7, and Z is CR.sup.8.

75. The compound of claim 74, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein each R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from hydrogen or halogen.

76. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.1 is hydrogen.

77. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.1 is optionally substituted C1-C6 alkyl.

78. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.2 is optionally substituted C1-C3 alkyl substituted with at least a halogen.

79. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.2 is optionally substituted C1 alkyl substituted with at least a F.

80. The compound of claim 69, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.2 is CHF.sub.2.

81. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each independently optionally substituted C1-C6 alkyl.

82. The compound of claim 81, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each independently methyl, ethyl, n-propyl, iso-propyl, n-butyl, or iso-butyl.

83. The compound of claim 82, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each methyl.

84. The compound of claim 82, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each ethyl.

85. The compound of claim 81, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered heterocyclyl.

86. The compound of claim 81, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 4- to 6-membered heterocyclyl.

87. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein L is a bond.

88. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein L is CH.sub.2.

89. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.9 is hydrogen.

90. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.9 is halogen.

91. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein R.sup.10 is hydrogen.

92. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein V is N.

93. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein V is CR.sup.11.

94. The compound of claim 68, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, wherein V is CR.sup.11 and R.sup.11 is hydrogen.

95. A pharmaceutical composition comprising the compound, of claim 67, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof, and a pharmaceutically acceptable excipient or carrier.

96. A method of treating an inflammatory or autoimmune disease or disorder in a patient in need thereof, comprising administering to the patient a therapeutically effectively amount of the compound of claim 67, or pharmaceutically acceptable salt, solvate, deuteroisotope, or N-oxide thereof.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0026] As used herein and in the appended claims, the singular forms a, and, and the include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to an agent includes a plurality of such agents, and reference to the cell includes reference to one or more cells (or to a plurality of cells) and equivalents thereof known to those skilled in the art, and so forth. When ranges are used herein for physical properties, such as molecular weight, or chemical properties, such as chemical formulae, all combinations and subcombinations of ranges and specific embodiments therein are intended to be included. The term about when referring to a number or a numerical range means that the number or numerical range referred to is an approximation within experimental variability (or within statistical experimental error), and thus the number or numerical range, in some instances, will vary between 1% and 15% of the stated number or numerical range. The term comprising (and related terms such as comprise or comprises or having or including) is not intended to exclude that in other certain embodiments, for example, an embodiment of any composition of matter, composition, method, or process, or the like, described herein, consist of or consist essentially of the described features.

Definitions

[0027] As used in the specification and appended claims, unless specified to the contrary, the following terms have the meaning indicated below.

[0028] Amino refers to the NH.sub.2 radical.

[0029] Cyano refers to the CN radical.

[0030] Nitro refers to the NO.sub.2 radical.

[0031] Oxa refers to the O radical.

[0032] Oxo refers to the ?O radical.

[0033] Thioxo refers to the ?S radical.

[0034] Imino refers to the ?NH radical.

[0035] Oximo refers to the ?NOH radical.

[0036] Hydrazino refers to the ?NNH.sub.2 radical.

[0037] Alkyl refers to a straight or branched hydrocarbon chain radical consisting solely of carbon and hydrogen atoms, containing no unsaturation, having from one to fifteen carbon atoms (e.g., C.sub.1-C.sub.15 alkyl). In certain embodiments, an alkyl comprises one to thirteen carbon atoms (e.g., C.sub.1-C.sub.13 alkyl). In certain embodiments, an alkyl comprises one to eight carbon atoms (e.g., C.sub.1-C.sub.5 alkyl). In other embodiments, an alkyl comprises one to five carbon atoms (e.g., C.sub.1-C.sub.5 alkyl). In other embodiments, an alkyl comprises one to four carbon atoms (e.g., C.sub.1-C.sub.4 alkyl). In other embodiments, an alkyl comprises one to three carbon atoms (e.g., C.sub.1-C.sub.3 alkyl). In other embodiments, an alkyl comprises one to two carbon atoms (e.g., C.sub.1-C.sub.2 alkyl). In other embodiments, an alkyl comprises one carbon atom (e.g., C.sub.1 alkyl). In other embodiments, an alkyl comprises five to fifteen carbon atoms (e.g., C.sub.5-C.sub.15 alkyl). In other embodiments, an alkyl comprises five to eight carbon atoms (e.g., C.sub.5-C.sub.8 alkyl). In other embodiments, an alkyl comprises two to five carbon atoms (e.g., C.sub.2-C.sub.5 alkyl). In other embodiments, an alkyl comprises three to five carbon atoms (e.g., C.sub.3-C.sub.5 alkyl). In other embodiments, the alkyl group is selected from methyl, ethyl, 1-propyl (n-propyl), 1-methylethyl (iso-propyl), 1-butyl (n-butyl), 1-methylpropyl (sec-butyl), 2-methylpropyl (iso-butyl), 1,1-dimethylethyl (tert-butyl), 1-pentyl (n-pentyl). The alkyl is attached to the rest of the molecule by a single bond. Unless stated otherwise specifically in the specification, an alkyl group is optionally substituted by one or more of the following substituents: halo, cyano, nitro, oxo, thioxo, imino, oximo, trimethylsilanyl, OR.sup.a, SR.sup.a, OC(O)R.sup.a, N(R.sup.a).sub.2, C(O)R.sup.a, C(O)OR.sup.a, C(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)OR.sup.a, OC(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)R.sup.a, N(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tOR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2) and S(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2) where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, carbocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), carbocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl). In certain embodiments, an optionally substituted alkyl is a haloalkyl. In other embodiments, an optionally substituted alkyl is a fluoroalkyl. In other embodiments, an optionally substituted alkyl is a CF.sub.3 group.

[0038] Alkoxy refers to a radical bonded through an oxygen atom of the formula O-alkyl, where alkyl is an alkyl chain as defined above.

[0039] Alkenyl refers to a straight or branched hydrocarbon chain radical group consisting solely of carbon and hydrogen atoms, containing at least one carbon-carbon double bond, and having from two to twelve carbon atoms. In certain embodiments, an alkenyl comprises two to eight carbon atoms. In other embodiments, an alkenyl comprises two to four carbon atoms. The alkenyl is attached to the rest of the molecule by a single bond, for example, ethenyl (i.e., vinyl), prop-1-enyl (i.e., allyl), but-1-enyl, pent-1-enyl, penta-1,4-dienyl, and the like. Unless stated otherwise specifically in the specification, an alkenyl group is optionally substituted by one or more of the following substituents: halo, cyano, nitro, oxo, thioxo, imino, oximo, trimethylsilanyl, OR.sup.a, SR, OC(O)R.sup.a, N(R.sup.a).sub.2, C(O)R.sup.a, C(O)OR.sup.a, C(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)OR.sup.a, OC(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)R.sup.a, N(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tOR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2) and S(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2) where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, carbocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), carbocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl).

[0040] Alkynyl refers to a straight or branched hydrocarbon chain radical group consisting solely of carbon and hydrogen atoms, containing at least one carbon-carbon triple bond, having from two to twelve carbon atoms. In certain embodiments, an alkynyl comprises two to eight carbon atoms. In other embodiments, an alkynyl comprises two to six carbon atoms. In other embodiments, an alkynyl comprises two to four carbon atoms. The alkynyl is attached to the rest of the molecule by a single bond, for example, ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like. Unless stated otherwise specifically in the specification, an alkynyl group is optionally substituted by one or more of the following substituents: halo, cyano, nitro, oxo, thioxo, imino, oximo, trimethylsilanyl, OR.sup.a, SR.sup.a, OC(O)R.sup.a, N(R.sup.a).sub.2, C(O)R.sup.a, C(O)OR.sup.a, C(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)OR.sup.a, OC(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)R.sup.a, N(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2) and S(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2) where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, carbocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), carbocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl).

[0041] Alkylene or alkylene chain refers to a straight or branched divalent hydrocarbon chain linking the rest of the molecule to a radical group, consisting solely of carbon and hydrogen, containing no unsaturation, and having from one to twelve carbon atoms, for example, methylene, ethylene, propylene, in-butylene, and the like. The alkylene chain is attached to the rest of the molecule through a single bond and to the radical group through a single bond. The points of attachment of the alkylene chain to the rest of the molecule and to the radical group are through one carbon in the alkylene chain or through any two carbons within the chain. In certain embodiments, an alkylene comprises one to eight carbon atoms (e.g., C.sub.1-C.sub.8 alkylene). In other embodiments, an alkylene comprises one to five carbon atoms (e.g., C.sub.1-C.sub.5 alkylene). In other embodiments, an alkylene comprises one to four carbon atoms (e.g., C.sub.1-C.sub.4 alkylene). In other embodiments, an alkylene comprises one to three carbon atoms (e.g., C.sub.1-C.sub.3 alkylene). In other embodiments, an alkylene comprises one to two carbon atoms (e.g., C.sub.1-C.sub.2 alkylene). In other embodiments, an alkylene comprises one carbon atom (e.g., C.sub.1 alkylene). In other embodiments, an alkylene comprises five to eight carbon atoms (e.g., C.sub.2-C.sub.8 alkylene). In other embodiments, an alkylene comprises two to five carbon atoms (e.g., C.sub.2-C.sub.5 alkylene). In other embodiments, an alkylene comprises three to five carbon atoms (e.g., C.sub.3-C.sub.5 alkylene). Unless stated otherwise specifically in the specification, an alkylene chain is optionally substituted by one or more of the following substituents: halo, cyano, nitro, oxo, thioxo, imino, oximo, trimethylsilanyl, OR.sup.a, SR.sup.a, OC(O)R.sup.a, N(R.sup.a).sub.2, C(O)R.sup.a, C(O)OR.sup.a, C(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)OR.sup.a, OC(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)R.sup.a, N(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tOR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2) and S(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2) where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, carbocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), carbocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl).

[0042] Alkenylene or alkenylene chain refers to a straight or branched divalent hydrocarbon chain linking the rest of the molecule to a radical group, consisting solely of carbon and hydrogen, containing at least one carbon-carbon double bond, and having from two to twelve carbon atoms. The alkenylene chain is attached to the rest of the molecule through a single bond and to the radical group through a single bond. In certain embodiments, an alkenylene comprises two to eight carbon atoms (e.g., C.sub.2-C.sub.8 alkenylene). In other embodiments, an alkenylene comprises two to five carbon atoms (e.g., C.sub.2-C.sub.5 alkenylene). In other embodiments, an alkenylene comprises two to four carbon atoms (e.g., C.sub.2-C.sub.4 alkenylene). In other embodiments, an alkenylene comprises two to three carbon atoms (e.g., C.sub.2-C.sub.3 alkenylene). In other embodiments, an alkenylene comprises two carbon atoms (e.g., C.sub.2 alkenylene). In other embodiments, an alkenylene comprises five to eight carbon atoms (e.g., C.sub.5-C.sub.8 alkenylene). In other embodiments, an alkenylene comprises three to five carbon atoms (e.g., C.sub.3-C.sub.5 alkenylene). Unless stated otherwise specifically in the specification, an alkenylene chain is optionally substituted by one or more of the following substituents: halo, cyano, nitro, oxo, thioxo, imino, oximo, trimethylsilanyl, OR.sup.a, SR.sup.a, OC(O)R.sup.a, N(R.sup.a).sub.2, C(O)R.sup.a, C(O)OR.sup.a, C(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)OR.sup.a, OC(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)R.sup.a, N(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tOR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2) and S(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2) where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, carbocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), carbocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl).

[0043] Alkynylene or alkynylene chain refers to a straight or branched divalent hydrocarbon chain linking the rest of the molecule to a radical group, consisting solely of carbon and hydrogen, containing at least one carbon-carbon triple bond, and having from two to twelve carbon atoms. The alkynylene chain is attached to the rest of the molecule through a single bond and to the radical group through a single bond. In certain embodiments, an alkynylene comprises two to eight carbon atoms (e.g., C.sub.2-C.sub.8 alkynylene). In other embodiments, an alkynylene comprises two to five carbon atoms (e.g., C.sub.2-C.sub.5 alkynylene). In other embodiments, an alkynylene comprises two to four carbon atoms (e.g., C.sub.2-C.sub.4 alkynylene). In other embodiments, an alkynylene comprises two to three carbon atoms (e.g., C.sub.2-C.sub.3 alkynylene). In other embodiments, an alkynylene comprises two carbon atoms (e.g., C.sub.2 alkynylene). In other embodiments, an alkynylene comprises five to eight carbon atoms (e.g., C.sub.5-C.sub.8alkynylene). In other embodiments, an alkynylene comprises three to five carbon atoms (e.g., C.sub.3-C.sub.5 alkynylene). Unless stated otherwise specifically in the specification, an alkynylene chain is optionally substituted by one or more of the following substituents: halo, cyano, nitro, oxo, thioxo, imino, oximo, trimethylsilanyl, OR.sup.a, SR, OC(O)R.sup.a, N(R.sup.a).sub.2, C(O)R.sup.a, C(O)OR.sup.a, C(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)OR.sup.a, OC(O)N(R.sup.a).sub.2, N(R.sup.a)C(O)R.sup.a, N(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2), S(O).sub.tR.sup.a (where t is 1 or 2) and S(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2) where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, carbocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), carbocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl).

[0044] Aryl refers to a radical derived from an aromatic monocyclic or multicyclic hydrocarbon ring system by removing a hydrogen atom from a ring carbon atom. The aromatic monocyclic or multicyclic hydrocarbon ring system contains only hydrogen and carbon from five to eighteen carbon atoms, where at least one of the rings in the ring system is fully unsaturated, i.e., it contains a cyclic, delocalized (4n+2) ?-electron system in accordance with the H?ckel theory. The ring system from which aryl groups are derived include, but are not limited to, groups such as benzene, fluorene, indane, indene, tetralin and naphthalene. Unless stated otherwise specifically in the specification, the term aryl or the prefix ar- (such as in aralkyl) is meant to include aryl radicals optionally substituted by one or more substituents independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, halo, cyano, nitro, R.sup.bOR.sup.a, R.sup.bOC(O)R.sup.a, R.sup.bOC(O)OR.sup.a, R.sup.bOC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a).sub.2, R.sup.bC(O)R.sup.a, R.sup.bC(O)OR.sup.a, R.sup.bC(O)N(R.sup.a).sub.2, R.sup.bOR.sup.cC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a)C(O)OR.sup.a, R.sup.bN(R.sup.a)C(O)R.sup.a, R.sup.bN(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), R.sup.bS(O).sub.tR.sup.a (where t is 1 or 2), R.sup.bS(O).sub.tOR.sup.a (where t is 1 or 2) and R.sup.bS(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2), where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, cycloalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), cycloalkylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), each R.sup.b is independently a direct bond or a straight or branched alkylene or alkenylene chain, and R.sup.c is a straight or branched alkylene or alkenylene chain, and where each of the R.sup.a, R.sup.b, or R.sup.c substituents is unsubstituted unless otherwise indicated.

[0045] Aralkyl refers to a radical of the formula R.sup.c-aryl where R.sup.c is an alkylene chain as defined above, for example, methylene, ethylene, and the like. The alkylene chain part of the aralkyl radical is optionally substituted as described above for an alkylene chain. The aryl part of the aralkyl radical is optionally substituted as described above for an aryl group.

[0046] Aralkenyl refers to a radical of the formula R.sup.d-aryl where R.sup.d is an alkenylene chain as defined above. The aryl part of the aralkenyl radical is optionally substituted as described above for an aryl group. The alkenylene chain part of the aralkenyl radical is optionally substituted as defined above for an alkenylene group.

[0047] Aralkynyl refers to a radical of the formula R.sup.e-aryl, where R.sup.e is an alkynylene chain as defined above. The aryl part of the aralkynyl radical is optionally substituted as described above for an aryl group. The alkynylene chain part of the aralkynyl radical is optionally substituted as defined above for an alkynylene chain.

[0048] Aralkoxy refers to a radical bonded through an oxygen atom of the formula OR.sup.c-aryl where R.sup.c is an alkylene chain as defined above, for example, methylene, ethylene, and the like. The alkylene chain part of the aralkyl radical is optionally substituted as described above for an alkylene chain. The aryl part of the aralkyl radical is optionally substituted as described above for an aryl group.

[0049] Carbocyclyl refers to a stable non-aromatic monocyclic or polycyclic hydrocarbon radical consisting solely of carbon and hydrogen atoms, which includes fused or bridged ring systems, having from three to fifteen carbon atoms. In certain embodiments, a carbocyclyl comprises three to ten carbon atoms. In other embodiments, a carbocyclyl comprises five to seven carbon atoms. The carbocyclyl is attached to the rest of the molecule by a single bond. Carbocyclyl is saturated (i.e., containing single CC bonds only) or unsaturated (i.e., containing one or more double bonds or triple bonds). A fully saturated carbocyclyl radical is also referred to as cycloalkyl. Examples of monocyclic cycloalkyls include, e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. An unsaturated carbocyclyl is also referred to as cycloalkenyl. Examples of monocyclic cycloalkenyls include, e.g., cyclopentenyl, cyclohexenyl, cycloheptenyl, and cyclooctenyl. Polycyclic carbocyclyl radicals include, for example, adamantyl, norbornyl (i.e., bicyclo[2.2.1]heptanyl), norbornenyl, decalinyl, 7,7-dimethyl-bicyclo[2.2.1]heptanyl, and the like. Unless otherwise stated specifically in the specification, the term carbocyclyl is meant to include carbocyclyl radicals that are optionally substituted by one or more substituents independently selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, halo, oxo, thioxo, cyano, nitro, R.sup.bOR.sup.a, R.sup.bOC(O)R.sup.a, R.sup.bOC(O)OR.sup.3, R.sup.bOC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a).sub.2, R.sup.bC(O)R.sup.a, R.sup.bC(O)OR.sup.a, R.sup.bC(O)N(R.sup.a).sub.2, R.sup.bOR.sup.cC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a)C(O)OR.sup.a, R.sup.bN(R.sup.a)C(O)R.sup.a, R.sup.bN(R.sup.a)S(OR.sup.a (where t is 1 or 2), R.sup.bS(OR.sup.a (where t is 1 or 2), R.sup.bS(O).sub.tOR.sup.a (where t is 1 or 2) and R.sup.bS(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2), where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, cycloalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), cycloalkylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), each R.sup.b is independently a direct bond or a straight or branched alkylene or alkenylene chain, and R.sup.c is a straight or branched alkylene or alkenylene chain, and where each of the R.sup.a, R.sup.b, or R.sup.c substituents is unsubstituted unless otherwise indicated.

[0050] Carbocyclylalkyl refers to a radical of the formula R.sup.c-carbocyclyl where R.sup.c is an alkylene chain as defined above. The alkylene chain and the carbocyclyl radical is optionally substituted as defined above.

[0051] Carbocyclylalkynyl refers to a radical of the formula R.sup.c-carbocyclyl where R.sup.c is an alkynylene chain as defined above. The alkynylene chain and the carbocyclyl radical is optionally substituted as defined above.

[0052] Carbocyclylalkoxy refers to a radical bonded through an oxygen atom of the formula OR.sup.c-carbocyclyl where R.sup.c is an alkylene chain as defined above. The alkylene chain and the carbocyclyl radical is optionally substituted as defined above.

[0053] Halo or halogen refers to bromo, chloro, fluoro or iodo substituents.

[0054] Fluoroalkyl refers to an alkyl radical, as defined above, that is substituted by one or more fluoro radicals, as defined above, for example, trifluoromethyl, difluoromethyl, fluoromethyl, 2,2,2-trifluoroethyl, 1-fluoromethyl-2-fluoroethyl, and the like. In some embodiments, the alkyl part of the fluoroalkyl radical is optionally substituted as defined above for an alkyl group.

[0055] Heterocyclyl refers to a stable 3- to 18-membered non-aromatic ring radical that comprises two to twelve carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen and sulfur. Unless stated otherwise specifically in the specification, the heterocyclyl radical is a monocyclic, bicyclic, tricyclic, or tetracyclic ring system, which optionally includes fused or bridged ring systems. The heteroatoms in the heterocyclyl radical are optionally oxidized. One or more nitrogen atoms, if present, are optionally quaternized. The heterocyclyl radical is partially or fully saturated. The heterocyclyl is attached to the rest of the molecule through any atom of the ring(s). Examples of such heterocyclyl radicals include, but are not limited to, dioxolanyl, thienyl[1,3]dithianyl, decahydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, isoxazolidinyl, morpholinyl, octahydroindolyl, octahydroisoindolyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, oxazolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazolidinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianyl, tetrahydropyranyl, thiomorpholinyl, thiamorpholinyl, 1-oxo-thiomorpholinyl, and 1,1-dioxo-thiomorpholinyl. Unless stated otherwise specifically in the specification, the term heterocyclyl is meant to include heterocyclyl radicals as defined above that are optionally substituted by one or more substituents selected from optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, halo, fluoroalkyl, oxo, thioxo, cyano, nitro, R.sup.bOR.sup.3, R.sup.bOC(O)R.sup.a, R.sup.bOC(O)OR.sup.a, R.sup.bOC(O)N(R.sup.3).sub.2, R.sup.bN(R.sup.a).sub.2, R.sup.bC(O)R.sup.a, R.sup.bC(O)OR.sup.a, R.sup.bC(O)N(R.sup.a).sub.2, R.sup.bOR.sup.cC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a)C(O)OR.sup.a, R.sup.bN(R.sup.a)C(O)R.sup.a, R.sup.bN(R.sup.a)S(O).sub.tR.sup.a (where t is 1 or 2), R.sup.bS(OR.sup.a (where t is 1 or 2), R.sup.bS(O).sub.tOR.sup.a (where t is 1 or 2) and R.sup.bS(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2), where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, cycloalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), cycloalkylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), each R.sup.b is independently a direct bond or a straight or branched alkylene or alkenylene chain, and R.sup.c is a straight or branched alkylene or alkenylene chain, and where each of the R.sup.a, R.sup.b, or R.sup.c substituents is unsubstituted unless otherwise indicated.

[0056] N-heterocyclyl or N-attached heterocyclyl refers to a heterocyclyl radical as defined above containing at least one nitrogen and where the point of attachment of the heterocyclyl radical to the rest of the molecule is through a nitrogen atom in the heterocyclyl radical. An N-heterocyclyl radical is optionally substituted as described above for heterocyclyl radicals. Examples of such N-heterocyclyl radicals include, but are not limited to, 1-morpholinyl, 1-piperidinyl, 1-piperazinyl, 1-pyrrolidinyl, pyrazolidinyl, and imidazolidinyl.

[0057] C-heterocyclyl or C-attached heterocyclyl refers to a heterocyclyl radical as defined above containing at least one heteroatom and where the point of attachment of the heterocyclyl radical to the rest of the molecule is through a carbon atom in the heterocyclyl radical. A C-heterocyclyl radical is optionally substituted as described above for heterocyclyl radicals. Examples of such C-heterocyclyl radicals include, but are not limited to, 2-morpholinyl, 2- or 3- or 4-piperidinyl, 2-piperazinyl, 2- or 3-pyrrolidinyl, and the like.

[0058] Heterocyclylalkyl refers to a radical of the formula R.sup.c-heterocyclyl where R.sup.c is an alkylene chain as defined above. If the heterocyclyl is a nitrogen-containing heterocyclyl, the heterocyclyl is optionally attached to the alkyl radical at the nitrogen atom. The alkylene chain of the heterocyclylalkyl radical is optionally substituted as defined above for an alkylene chain. The heterocyclyl part of the heterocyclylalkyl radical is optionally substituted as defined above for a heterocyclyl group.

[0059] Heterocyclylalkoxy refers to a radical bonded through an oxygen atom of the formula OR.sup.c-heterocyclyl where R.sup.c is an alkylene chain as defined above. If the heterocyclyl is a nitrogen-containing heterocyclyl, the heterocyclyl is optionally attached to the alkyl radical at the nitrogen atom. The alkylene chain of the heterocyclylalkoxy radical is optionally substituted as defined above for an alkylene chain. The heterocyclyl part of the heterocyclylalkoxy radical is optionally substituted as defined above for a heterocyclyl group.

[0060] Heteroaryl refers to a radical derived from a 3- to 18-membered aromatic ring radical that comprises two to seventeen carbon atoms and from one to six heteroatoms selected from nitrogen, oxygen, and sulfur. As used herein, the heteroaryl radical is a monocyclic, bicyclic, tricyclic, or tetracyclic ring system, wherein at least one of the rings in the ring system is fully unsaturated, i.e., it contains a cyclic, delocalized (4n+2) ?-electron system in accordance with the H?ckel theory. Heteroaryl includes fused or bridged ring systems. The heteroatom(s) in the heteroaryl radical is optionally oxidized. One or more nitrogen atoms, if present, are optionally quaternized. The heteroaryl is attached to the rest of the molecule through any atom of the ring(s). Examples of heteroaryls include, but are not limited to, azepinyl, acridinyl, benzimidazolyl, benzindolyl, 1,3-benzodioxolyl, benzofuranyl, benzooxazolyl, benzo[d]thiazolyl, benzothiadiazolyl, benzo[b][1,4]dioxepinyl, benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, benzonaphthofuranyl, benzoxazolyl, benzodioxolyl, benzodioxinyl, benzopyranyl, benzopyranonyl, benzofuranyl, benzofuranonyl, benzothienyl (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriazolyl, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnolinyl, cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5,6-dihydrobenzo[h]cinnolinyl, 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazinyl, dibenzofuranyl, dibenzothiophenyl, furanyl, furanonyl, furo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocycloocta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, indazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indolizinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthyridinyl, 1,6-naphthyridinonyl, oxadiazolyl, 2-oxoazepinyl, oxazolyl, oxiranyl, 5,6,6a,7,8,9,10,10a-octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phenothiazinyl, phenoxazinyl, phthalazinyl, pteridinyl, purinyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d]pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyridazinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyridinyl, and thiophenyl (i.e. thienyl). Unless stated otherwise specifically in the specification, the term heteroaryl is meant to include heteroaryl radicals as defined above which are optionally substituted by one or more substituents selected from optionally substituted alkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclylalkyl, optionally substituted alkenyl, optionally substituted alkynyl, halo, optionally substituted fluoroalkyl, optionally substituted haloalkenyl, optionally substituted haloalkynyl, oxo, thioxo, cyano, nitro, R.sup.bOR.sup.a, R.sup.bOC(O)R.sup.a, R.sup.bOC(O)OR.sup.a, R.sup.bOC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a).sub.2, R.sup.bC(O)R.sup.a, R.sup.bC(O)OR.sup.a, R.sup.bC(O)N(R.sup.a).sub.2, R.sup.bOR.sup.cC(O)N(R.sup.a).sub.2, R.sup.bN(R.sup.a)C(O)OR.sup.a, R.sup.bN(R.sup.a)C(O)R.sup.a, R.sup.bN(R.sup.a)S(O).sub.tNR.sup.a (where t is 1 or 2), R.sup.bS(O).sub.tR.sup.a (where t is 1 or 2), R.sup.bS(O).sub.tOR.sup.a (where t is 1 or 2) and R.sup.bS(O).sub.tN(R.sup.a).sub.2 (where t is 1 or 2), where each R.sup.a is independently hydrogen, alkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), fluoroalkyl, cycloalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), cycloalkylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), aralkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heterocyclylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), heteroaryl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), or heteroarylalkyl (optionally substituted with halogen, hydroxy, methoxy, or trifluoromethyl), each R.sup.b is independently a direct bond or a straight or branched alkylene or alkenylene chain, and R.sup.c is a straight or branched alkylene or alkenylene chain, and where each of the R.sup.a, R.sup.b, or R.sup.c substituents is unsubstituted unless otherwise indicated.

[0061] N-heteroaryl refers to a heteroaryl radical as defined above containing at least one nitrogen and where the point of attachment of the heteroaryl radical to the rest of the molecule is through a nitrogen atom in the heteroaryl radical. An N-heteroaryl radical is optionally substituted as described above for heteroaryl radicals.

[0062] C-heteroaryl refers to a heteroaryl radical as defined above and where the point of attachment of the heteroaryl radical to the rest of the molecule is through a carbon atom in the heteroaryl radical. A (C-heteroaryl radical is optionally substituted as described above for heteroaryl radicals.

[0063] Heteroarylalkyl refers to a radical of the formula R.sup.c-heteroaryl, where R.sup.c is an alkylene chain as defined above. If the heteroaryl is a nitrogen-containing heteroaryl, the heteroaryl is optionally attached to the alkyl radical at the nitrogen atom. The alkylene chain of the heteroarylalkyl radical is optionally substituted as defined above for an alkylene chain. The heteroaryl part of the heteroarylalkyl radical is optionally substituted as defined above for a heteroaryl group.

[0064] Heteroarylalkoxy refers to a radical bonded through an oxygen atom of the formula OR.sup.c-heteroaryl, where R.sup.c is an alkylene chain as defined above. If the heteroaryl is a nitrogen-containing heteroaryl, the heteroaryl is optionally attached to the alkyl radical at the nitrogen atom. The alkylene chain of the heteroarylalkoxy radical is optionally substituted as defined above for an alkylene chain. The heteroaryl part of the heteroarylalkoxy radical is optionally substituted as defined above for a heteroaryl group.

[0065] The compounds disclosed herein, in some embodiments, contain one or more asymmetric centers and thus give rise to enantiomers, diastereomers, and other stereoisomeric forms that are defined, in terms of absolute stereochemistry, as (R)- or (S)-. Unless stated otherwise, it is intended that all stereoisomeric forms of the compounds disclosed herein are contemplated by this disclosure. When the compounds described herein contain alkene double bonds, and unless specified otherwise, it is intended that this disclosure includes both E and Z geometric isomers (e.g., cis or trans.) Likewise, all possible isomers, as well as their racemic and optically pure forms, and all tautomeric forms are also intended to be included. The term geometric isomer refers to E or Z geometric isomers (e.g., cis or trans) of an alkene double bond. The term positional isomer refers to structural isomers around a central ring, such as ortho-, meta-, and para-isomers around a benzene ring.

[0066] As used herein, carboxylic acid bioisostere refers to a functional group or moiety that exhibits similar physical, biological and/or chemical properties as a carboxylic acid moiety. Examples of carboxylic acid bioisosteres include, but are not limited to,

##STR00003##

and the like.

[0067] A tautomer refers to a molecule wherein a proton shift from one atom of a molecule to another atom of the same molecule is possible. The compounds presented herein, in certain embodiments, exist as tautomers. In circumstances where tautomerization is possible, a chemical equilibrium of the tautomers will exist. The exact ratio of the tautomers depends on several factors, including physical state, temperature, solvent, and pH. Some examples of tautomeric equilibrium include:

##STR00004##

[0068] The compounds disclosed herein, in some embodiments, are used in different enriched isotopic forms, e.g., enriched in the content of .sup.2H, .sup.3H, .sup.11C, .sup.13C and/or .sup.14C. In one particular embodiment, the compound is deuterated in at least one position. Such deuterated forms can be made by the procedure described in U.S. Pat. Nos. 5,846,514 and 6,334,997. As described in U.S. Pat. Nos. 5,846,514 and 6,334,997, deuteration can improve the metabolic stability and or efficacy, thus increasing the duration of action of drugs.

[0069] Unless otherwise stated, structures depicted herein are intended to include compounds which differ only in the presence of one or more isotopically enriched atoms. For example, compounds having the present structures except for the replacement of a hydrogen by a deuterium or tritium, or the replacement of a carbon by .sup.13C- or .sup.14C-enriched carbon are within the scope of the present disclosure.

[0070] The compounds of the present disclosure optionally contain unnatural proportions of atomic isotopes at one or more atoms that constitute such compounds. For example, the compounds may be labeled with isotopes, such as for example, deuterium (.sup.2H), tritium (.sup.3H), iodine-125 (.sup.121I) or carbon-14 (.sup.14C). Isotopic substitution with .sup.2H, .sup.11C, .sup.13C, .sup.14C, .sup.15C, .sup.12N, .sup.13N, .sup.15N, .sup.16N, .sup.16O, .sup.17O, .sup.19F, .sup.15F, .sup.16F, .sup.17F, .sup.18F, .sup.33S, .sup.34S, .sup.35S, .sup.36S, .sup.35Cl, .sup.37Cl, .sup.79Br, .sup.81Br, .sup.125I are all contemplated. In some embodiments, isotopic substitution with .sup.18F is contemplated. All isotopic variations of the compounds of the present invention, whether radioactive or not, are encompassed within the scope of the present invention.

[0071] In certain embodiments, the compounds disclosed herein have some or all of the .sup.1H atoms replaced with .sup.2H atoms. The methods of synthesis for deuterium-containing compounds are known in the art and include, by way of non-limiting example only, the following synthetic methods.

[0072] Deuterium substituted compounds are synthesized using various methods such as described in: Dean, Dennis C., Editor. Recent Advances in the Synthesis and Applications of Radiolabeled Compounds for Drug Discovery and Development. [Curr., Pharm. Des., 2000; 6(10)] 2000, 110 pp; George W.; Varma, Rajender S. The Synthesis of Radiolabeled Compounds via Organometallic Intermediates, Tetrahedron, 1989, 45(21), 6601-21; and Evans, E. Anthony. Synthesis of radiolabeled compounds, J. Radioanal. Chem., 1981, 64(1-2), 9-32.

[0073] Deuterated starting materials are readily available and are subjected to the synthetic methods described herein to provide for the synthesis of deuterium-containing compounds. Large numbers of deuterium-containing reagents and building blocks are available commercially from chemical vendors, such as Aldrich Chemical Co.

[0074] Deuterium-transfer reagents suitable for use in nucleophilic substitution reactions, such as iodomethane-d.sub.3 (CD.sub.3I), are readily available and may be employed to transfer a deuterium-substituted carbon atom under nucleophilic substitution reaction conditions to the reaction substrate. The use of CD.sub.3I is illustrated, by way of example only, in the reaction schemes below.

##STR00005##

[0075] Deuterium-transfer reagents, such as lithium aluminum deuteride (LiAlD.sub.4), are employed to transfer deuterium under reducing conditions to the reaction substrate. The use of LiAlD.sub.4 is illustrated, by way of example only, in the reaction schemes below.

##STR00006##

[0076] Deuterium gas and palladium catalyst are employed to reduce unsaturated carbon-carbon linkages and to perform a reductive substitution of aryl carbon-halogen bonds as illustrated, by way of example only, in the reaction schemes below.

##STR00007##

[0077] In one embodiment, the compounds disclosed herein contain one deuterium atom. In another embodiment, the compounds disclosed herein contain two deuterium atoms. In another embodiment, the compounds disclosed herein contain three deuterium atoms. In another embodiment, the compounds disclosed herein contain four deuterium atoms. In another embodiment, the compounds disclosed herein contain five deuterium atoms. In another embodiment, the compounds disclosed herein contain six deuterium atoms. In another embodiment, the compounds disclosed herein contain more than six deuterium atoms. In another embodiment, the compound disclosed herein is fully substituted with deuterium atoms and contains no non-exchangeable .sup.1H hydrogen atoms. In one embodiment, the level of deuterium incorporation is determined by synthetic methods in which a deuterated synthetic building block is used as a starting material.

[0078] Pharmaceutically acceptable salt includes both acid and base addition salts. A pharmaceutically acceptable salt of any one of the TNF? inhibitory compounds described herein is intended to encompass any and all pharmaceutically suitable salt forms. Preferred pharmaceutically acceptable salts of the compounds described herein are pharmaceutically acceptable acid addition salts and pharmaceutically acceptable base addition salts.

[0079] Pharmaceutically acceptable acid addition salt refers to those salts which retain the biological effectiveness and properties of the free bases, which are not biologically or otherwise undesirable, and which are formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, hydroiodic acid, hydrofluoric acid, phosphorous acid, and the like. Also included are salts that are formed with organic acids such as aliphatic mono- and dicarboxylic acids, phenyl-substituted alkanoic acids, hydroxy alkanoic acids, alkanedioic acids, aromatic acids, aliphatic and. aromatic sulfonic acids, etc. and include, for example, acetic acid, trifluoroacetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid, and the like. Exemplary salts thus include sulfates, pyrosulfates, bisulfates, sulfites, bisulfites, nitrates, phosphates, monohydrogenphosphates, dihydrogenphosphates, metaphosphates, pyrophosphates, chlorides, bromides, iodides, acetates, trifluoroacetates, propionates, caprylates, isobutyrates, oxalates, malonates, succinate suberates, sebacates, fumarates, maleates, mandelates, benzoates, chlorobenzoates, methylbenzoates, dinitrobenzoates, phthalates, benzenesulfonates, toluenesulfonates, phenylacetates, citrates, lactates, malates, tartrates, methanesulfonates, and the like. Also contemplated are salts of amino acids, such as arginates, gluconates, and galacturonates (see, for example, Berge S. M. et al., Pharmaceutical Salts, Journal of Pharmaceutical Science, 66:1-19 (1997)). Acid addition salts of basic compounds are, in some embodiments, prepared by contacting the free base forms with a sufficient amount of the desired acid to produce the salt according to methods and techniques with which a skilled artisan is familiar.

[0080] Pharmaceutically acceptable base addition salt refers to those salts that retain the biological effectiveness and properties of the free acids, which are not biologically or otherwise undesirable. These salts are prepared from addition of an inorganic base or an organic base to the free acid. Pharmaceutically acceptable base addition salts are, in some embodiments, formed with metals or amines, such as alkali and alkaline earth metals or organic amines. Salts derived from inorganic bases include, but are not limited to, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Salts derived from organic bases include, but are not limited to, salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, for example, isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, diethanolamine, 2-dimethylaminoethanol, 2-diethylaminoethanol, dicyclohexylamine, lysine, arginine, histidine, caffeine, procaine, N,N-dibenzylethylenediamine, chloroprocaine, hydrabamine, choline, betaine, ethylenediamine, ethylenedianiline, N-methylglucamine, glucosamine, methylglucamine, theobromine, purines, piperazine, piperidine, N-ethylpiperidine, polyamine resins and the like. See Berge et al., supra.

[0081] Pharmaceutically acceptable solvate refers to a composition of matter that is the solvent addition form. In some embodiments, solvates contain either stoichiometric or non-stoichiometric amounts of a solvent, and are formed during the process of making with pharmaceutically acceptable solvents such as water, ethanol, and the like. Hydrates are formed when the solvent is water, or alcoholates are formed when the solvent is alcohol. Solvates of compounds described herein are conveniently prepared or formed during the processes described herein. The compounds provided herein exist in either unsolvated or solvated forms.

[0082] The term subject or patient encompasses mammals. Examples of mammals include, but are not limited to, any member of the Mammalian class: humans, non-human primates such as chimpanzees, and other apes and monkey species; farm animals such as cattle, horses, sheep, goats, swine; domestic animals such as rabbits, dogs, and cats, laboratory animals including rodents, such as rats, mice and guinea pigs, and the like. In one aspect, the mammal is a human.

[0083] As used herein, treatment or treating, or palliating or ameliorating are used interchangeably. These terms refer to an approach for obtaining beneficial or desired results including but not limited to therapeutic benefit and/or a prophylactic benefit. By therapeutic benefit is meant eradication or amelioration of the underlying disorder being treated. Also, a therapeutic benefit is achieved with the eradication or amelioration of one or more of the physiological symptoms associated with the underlying disorder such that an improvement is observed in the patient, notwithstanding that the patient is still afflicted with the underlying disorder. For prophylactic benefit, the compositions are, in some embodiments, administered to a patient at risk of developing a particular disease, or to a patient reporting one or more of the physiological symptoms of a disease, even though a diagnosis of this disease has not been made.

[0084] Tumor Necrosis Factor Alpha (TNF?) Protein and Function

[0085] Tumor necrosis factor alpha (TNF?) proteins are members of the TNF superfamily, comprising various transmembrane proteins with a homologous TNF domain forming trimers. The TNF superfamily comprises 19 family members, including, but not limited to tumor necrosis factor alpha (also known as tumor necrosis factor, or TNF), lymphotoxin alpha (TNF?), lymphotoxin beta (TNF?), OX40 ligand, CD40 ligand, Fas ligand, CD27 ligand, CD30 ligand, CD137 ligand, CD137 ligand, and TNF-related apoptosis-inducing ligand. TNF? proteins are cytokines and adipokines (cytokines secreted by adipose tissue).

[0086] TNF? is a transmembrane protein, with soluble TNF? (sTNF?) released via protein cleavage. The sTNF? can propagate signaling by binding to two receptors, TNFR1 and TNFR2. TNF? is a regulator of immune responses for cell signaling and can mediate cell survival and cell death inducing signaling. There are two receptors for TNF signaling, TNFR1 and TNFR2. sTNF?-TNFR1 signaling promotes immune cell activation and drives acute and chronic inflammation. Membrane TNF?-TNFR2 signaling promotes inflammation resolution, immune cell regulatory functions and cell survival.

[0087] The extracellular region of both TNFR1 and TNFR2 have four homologous cysteine-rich domains, but they have structurally different intracellular regions. TNFR1 has a protein binding region called a death domain which allows homo- and hetero-typic interactions with other death domain-containing proteins. In contrast, TNFR2 has a TNF Receptor Associated Factor (TRAF) that interacts with TRAF family of signaling adaptors. The distinct profiles and differences of the two TNF receptors influence the cellular activity and physiological roles. TNFR1 can activate NF-?B and MAPK signaling, and cell death, and is important to regulate inflammatory diseases. TNFR2 is highly regulated and restricted to specific cell types such as endothelial cells and T cells. TNFR1 primarily promotes tissue degeneration and inflammation, while TNFR2 typically mediates local homeostatic effects such as tissue regeneration and cell survival (D. Fresegna et al., Cells, 2020, 9, 2290).

[0088] Binding of TNF? to TNFR1 can activate NF-?B for mediating transcription of various proteins involved in cell survival and proliferation, anti-apoptotic factors, and inflammatory response. Further, the MAPK pathway can also be activated by binding of TNF? to TNFR1, which is involved in cell differentiation and proliferation. When TNF? binds to TNFR1, it triggers receptor trimerization, leading to the assembly of a TNFR1-associated signaling complex. This complex recruits the receptor interacting protein 1 (RIP1) and TNF receptor associated death domain (TRADD) to the TNFR1 through the receptive death domains. TRADD then recruits adaptor proteins TRAF2 and TRAF5, which can engage the E3 ligases cellular inhibitors of apoptosis (c-IAP1, c-IAP2). c-IAP1/2 are important for TNFR1 complex signaling, which can eventually lead to the recruitment of the signaling kinase complexes of kinase IKK? and IKK?, which are inhibitors of kappa B kinase 1 and 2, and transforming growth factor beta-activated kinase 1 (TAK1) leading to activation of NF-?B and MAPK signaling. Activation of these signaling pathways can result in gene activation and expression of pro-inflammatory cytokines and pro-survival proteins.

[0089] TNF signaling is regulated by post-translational ubiquitination, which is essential for my biological processes. Post-translational modifications of TNFR1-associated signaling complexes can result in a change from inflammatory gene signaling to cell death. This switch is dependent upon the ubiquitination status of RIP1, which is formed as part of the TNFR1-associated signaling complex from TNF? binding.

[0090] TNF has long been known to be a key regulator of the inflammatory response, and recently has been known to be involved in brain functioning (D. Fresegna et al., Cells, 2020, 9, 2290). As a regulator of the inflammatory response, TNF can regulate many aspects of T cell biology including, but not limited to proliferation, survival, priming, and apoptotic fate. TNF is also known to play a role in conclusion of lymphocyte response, by the ability to promote cell death in both CD4 and CD8P T cells, through TNFR1. Specific inflammatory conditions can also result in TNFR2 promoting or supporting T cell apoptosis.

[0091] In normal adult brains, TNF is expressed at low levels, and it is believed that the expression could be influenced by presence or absence of cytokines that can cross the blood brain barrier. TNFRs in the brain are expressed by glia and neurons cells, and have regulatory functions, including, but not limited to homeostatic synaptic plasticity, astrocyte-mediated synaptic transmission, and neurogenesis. These functions are useful for regulating learning and memory functions amongst other roles.

[0092] TNF is recognized to be physiological gliotransmitter for the communication between neurons and glial cells, which in turn affects synaptic regulation. Glial TNF is important for maintenance of normal surface expression of AMPA receptors, and for homeostatic synaptic scaling, which allows for adjustment of the strength of all synapses on a neuron.

Prior Art Small Molecules Inhibitors

[0093] Diseases treated with biologic TNF? inhibitors include, but are not limited to rheumatoid arthritis, inflammatory bowel disease, psoriatic arthritis, psoriasis, and ankylosing spondylitis. Patients with neuroinflammatory conditions and degenerative disease, including, but not limited to Alzheimer's disease, Parkinson's disease, multiple sclerosis, treatment resistant depression, and tinnitus, may benefit from treatment with oral CNS sTNF? inhibitors by disrupting the sTNF? signaling and sparing the mTNF? signaling. Previous reports have also indicated targeting TNFR2 for treating Alzheimer's Disease (N. Orti-Casa? et al., Front Neurosci. 2019; 13: 49).

[0094] Small molecules have been developed for treatment of rheumatoid arthritis as some patients have responded poorly to monotherapy of approved anti-TNF? drugs (J. D. Dietrich et al., J. Med. Chem. 2021, 64, 417-429). Anti-TNF? drugs have also been expanded for use in other chronic autoimmune diseases, including, but not limited to, Crohn's disease, psoriasis, psoriatic arthritis, ulcerative colitis, inflammatory bowel disease, ankylosing spondylitis, and juvenile rheumatoid arthritis. Small molecules have been developed as an alternative to anti-TNF? biologics since the long-term clinical response rate is generally around 60-70% for rheumatoid arthritis.

[0095] Previous research has also indicated that TNF? inhibitors can be therapeutic for treatment of multiple sclerosis (D. Fresegna et al., Cells, 2020, 9, 2290). There has been evidence of the involvement of TNF in various pathological issues of multiple sclerosis, including immune dysregulation, demylination, synaptopathy, and neuroinflammation. TNF? inhibitors have the potential for treatment of multiple sclerosis, other potential chronic neurodegenerative diseases of the central nervous system.

[0096] More than 50 million Americans struggle with tinnitus, which is the hearing of a sound with no external source. It has been shown that TNF? is necessary for noise-induced neuroinflammation and synaptic imbalance (W. Wang et al., PLoS Biol. 2019 Jun. 18; 17(6):e3000307; A. Shulman et al., Curr Top Behav Neurosci. 2021; 51:161-174). It is believed that certain inhibitors of TNF? have activities for treating tinnitus.

[0097] Recent reports also indicate that TNF? inhibitors can be used alone or in combination for treatment with inflammatory bowel disease (S. F. Fowler Braga and K. J. Clark, US Pharm. 2021; 46(5):34-37). TNF? is a mediator of the abnormal immune response of inflammatory bowel disease, which leads to disruption of the intestinal mucosa and epithelial wall barrier. The anti-TNF agents can block TNF-mediated activation of the proinflammatory pathways to result in decreased immune-mediated inflammation.

[0098] Small molecule sTNF? inhibitors are active in pharmacology models of sTNF?/TNFR1 signaling in addition to demonstrating efficacy in a model of collagen antibody induced arthritis. There is currently limited data in the public domain for small molecule sTNF? inhibitors. Some TNF? inhibitors include, but are not limited to XPro1595, Etanercept, Infliximab, Adalimumab, Certolizumab pegol, Golimumamb, and other inhibitors described in TNF-?: The Shape of Small Molecules to Come? (A. D?mling and X. Li, Drug Discov Today 2022 January; 27(1):3-7) and Small Molecules that Inhibit TNF Signalling by Stabilising an Asymmetric Form of the Trimer (J. O'Connell et al., Nature Communications 10, 5795 (2019)). Additional small molecule inhibitors of TNF? include, but are not limited to the inhibitors described in Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF? Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches (H-Y Xiao et al., J. Med. Chem. 2020, 15050-15071), Development of Orally Efficacious Allosteric Inhibitors of TNF? via Fragment-Based Drug Design (J. D. Dietrich et al., J. Med. Chem. 2021, 64, 417-429), and Small-Molecule Inhibition of TNF-? (M. M. He et al., Science, 310 (2015), 1022-1025).

[0099] Small molecule sTNF? inhibitors have potential as a valuable therapy for patients currently treated with biologic TNF? inhibitors which affect mTNF? with the ability to fine tune oral dosing requirements and avoid anti-drug antibody responses, thereby improving short and long responses (A. D?mling and X. Li, Drug Discov Today 2022 January; 27(1):3-7).

[0100] Novel Compounds Inhibiting TNF?

[0101] In one aspect, provided herein are TNF? inhibitory compounds.

[0102] One embodiment provides a compound of Formula (I), or pharmaceutically acceptable salt, solvate, or N-oxide thereof:

##STR00008##

wherein, [0103] Ring A is selected from

##STR00009## wherein the * denotes point of attachment to L, or an optionally substituted heteroarylene selected from pyrazolene, imidazoline, oxazolene, or thiazolene; [0104] V is N or CR.sup.11; [0105] W is N or CR.sup.5; [0106] X is N or CR.sup.6; [0107] Y is N or CR.sup.7; [0108] Z is N or CR.sup.8; [0109] L is a bond, NH, (CH.sub.2)n-, CR.sup.12R.sup.13, O(CH.sub.2)n-*, or NH(CH.sub.2)n-*, wherein the * denotes point of attachment to phosphorous, n is 1, 2, or 3; [0110] R.sup.1 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, or optionally substituted C4-C7 cycloalkylalkyl; [0111] R.sup.2 is hydrogen, or optionally substituted C1-C3 alkyl; [0112] R.sup.3 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; [0113] R.sup.4 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; [0114] or R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered ring; [0115] each R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from hydrogen, halogen, CN, NH.sub.2, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or NH(optionally substituted C1-C3 alkyl); [0116] R.sup.9 is selected from hydrogen, halogen, or optionally substituted C1-C6 alkyl; [0117] R.sup.10 is selected from hydrogen or halogen; [0118] R.sup.11 is selected from hydrogen, halogen, or optionally substituted C1-C6 alkyl; and [0119] R.sup.12 and R.sup.3 are independently selected from hydrogen, OH, F, and CH.sub.3.

[0120] One embodiment provides compound of Formula (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof:

##STR00010##

wherein, [0121] Ring A is selected from

##STR00011## wherein the * denotes point of attachment to L, or an optionally substituted heteroarylene selected from pyrazolene, imidazoline, oxazolene, or thiazolene; [0122] V is N or CR.sup.11; [0123] W is N or CR.sup.5; [0124] X is N or CR.sup.6; [0125] Y is N or CR.sup.7; [0126] Z is N or CR.sup.8; [0127] L is a bond, NH, (CH.sub.2)n-, O(CH.sub.2)n-*, or NH(CH.sub.2)n-*, wherein the * denotes point of attachment to phosphorous; [0128] n is 1, 2, or 3; [0129] R.sup.1 is selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, or optionally substituted C4-C7 cycloalkylalkyl; [0130] R.sup.2 is hydrogen, or optionally substituted C1-C3 alkyl; [0131] R.sup.3 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; [0132] R.sup.4 is hydroxy, optionally substituted C1-C3 alkoxy, or optionally substituted C1-C6 alkyl; [0133] or R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered ring; [0134] each R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from hydrogen, halogen, CN, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or NH(optionally substituted C1-C3 alkyl); [0135] R.sup.9 is selected from hydrogen, halogen, or optionally substituted C1-C6 alkyl; [0136] R.sup.10 is selected from hydrogen or halogen; and [0137] R.sup.11 is selected from hydrogen, halogen, or optionally substituted C1-C6 alkyl.

[0138] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein ring A is selected from

##STR00012##

wherein the * denotes point of attachment to L.

[0139] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is N. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CR.sup.5.

[0140] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein X is N. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein X is CR.sup.6.

[0141] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein Y is N. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein Y is CR.sup.7.

[0142] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein Z is N. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein Z is CR.sup.8.

[0143] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CR.sup.5, X is CR.sup.6, Y is CR.sup.7, and Z is CR.sup.8. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CF, X is CH, Y is CH, and Z is CH.

[0144] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein each R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is independently selected from hydrogen or halogen.

[0145] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is N, X is CR.sup.6, Y is CR.sup.7, and Z is CR.sup.8.

[0146] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CR.sup.5, X is N, Y is CR.sup.7, and Z is CR.sup.8.

[0147] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CR.sup.5, X is CR.sup.6, Y is N, and Z is CR.sup.8.

[0148] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CR.sup.5, X is CR.sup.6, Y is CR.sup.7, and Z is N.

[0149] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is hydrogen.

[0150] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is optionally substituted C1-C6 alkyl.

[0151] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CH.sub.3.

[0152] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CD3.

[0153] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.2 is optionally substituted C1-C3 alkyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein the optionally substituted C1-C3 alkyl is substituted with a halogen. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein the optionally substituted C1-C3 alkyl is CHF.sub.2.

[0154] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein one of R.sup.3 or R.sup.4 is hydroxy. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are hydroxy. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein one of R.sup.3 or R.sup.4 is optionally substituted C1-C3 alkoxy. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are optionally substituted C1-C3 alkoxy. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein one of R.sup.3 or R.sup.4 is optionally substituted C1-C3 alkoxy. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are optionally substituted C1-C3 alkoxy. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each independently optionally substituted C1-C6 alkyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each independently methyl, ethyl, n-propyl, iso-propyl, n-butyl, or iso-butyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each methyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each ethyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 is hydroxy and R.sup.4 is methyl, ethyl, n-propyl, iso-propyl, n-butyl, or iso-butyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 are each methyl or ethyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 is OH and R.sup.4 is methyl.

[0155] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered heterocyclyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 3- to 8-membered heterocyclyl which comprises 1 or 2 additional heteroatoms each independently selected from N, O, and S. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 4- to 6-membered heterocyclyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 4-membered heterocyclyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 5-membered heterocyclyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 join to form optionally substituted phosphorus-containing 6-membered heterocyclyl.

[0156] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 taken together with the phosphorus atom to which they are attached to join to form a ring selected from:

##STR00013##

Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.3 and R.sup.4 taken together with the phosphorus atom to which they are attached to join to form a ring selected from:

##STR00014##

[0157] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein L is a bond. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein L is CH.sub.2. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein L is OCH.sub.2*. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein L is NHCH.sub.2*.

[0158] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.a is hydrogen. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.9 is halogen. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.10 is hydrogen.

[0159] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein ring A is an optionally substituted heteroarylene.

[0160] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein the optionally substituted heteroarylene is a N-linked heteroarylene, wherein the N-link is to the benzimidazole ring of Formula (I).

[0161] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein the optionally substituted heteroarylene is a C-linked heteroarylene, wherein the C-link is to the benzimidazole ring of Formula (I).

[0162] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein V is N. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein V is CR.sup.11. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein V is CR.sup.11 and R.sup.11 is hydrogen.

[0163] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CF, X is CH, Y is CH, and Z is CH; and L is a bond. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein L is a bond, and R.sup.3 and R.sup.4 are each methyl or ethyl. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein W is CF, X is CH, Y is CH, and Z is CH; L is a bond; and R.sup.3 and R.sup.4 are each methyl.

[0164] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CD3; and R.sup.2 is C1-C3 alkyl substituted with a halogen. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CD.sub.3; and R.sup.2 is CHF.sub.2.

[0165] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.9 is hydrogen, R.sup.10 is hydrogen, and V is CH. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.9 is F, R.sup.10 is hydrogen, and V is CH. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.9 is hydrogen, R.sup.10 is hydrogen, and V is CF.

[0166] Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CD.sub.3; R.sup.2 is C1-C3 alkyl substituted with a halogen; R.sup.9 is hydrogen; R.sup.10 is hydrogen; and V is CH. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CD.sub.3; R.sup.2 is C1-C3 alkyl substituted with a halogen; R.sup.a is F; R.sup.10 is hydrogen; and V is CH. Another embodiment provides the compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein R.sup.1 is CD.sub.3, R.sup.2 is C1-C3 alkyl substituted with a halogen; R.sup.6 is hydrogen; R.sup.10 is hydrogen; and V is CF.

[0167] One embodiment provides a TNF? inhibitory compound, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, having a structure presented in Table 1.

TABLE-US-00001 TABLE 1 Synthetic Chemistry Example Compound Structure Compound Name 1 [00015] (7R,14R)-1-(difluoromethoxy)-11-(2- (dimethylphosphoryl)pyrimidin-5-yl)- 6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 2 [00016] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)pyridin-3-yl)-6- methyl-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 3 [00017] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)pyridin-3-yl)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 4 [00018] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-5-fluoropyridin-3- yl)-6-methyl-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 5 [00019] (1R,11R)-18-(difluoromethoxy)-12- methyl-5-[6-(1-oxo-1lambda5- phospholan-1-yl)pyridin-3-yl]-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 6 [00020] (1R,11R)-18-(difluoromethoxy)-12- methyl-5-[6-(4-oxo-1,4lambda5- oxaphosphinan-4-yl)pyridin-3-yl]-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 7 [00021] (1R,11R)-18-(difluoromethoxy)-5-{6- [(dimethylphosphoryl)methoxy]pyridin- 3-yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 8 [00022] (1R,11R)-18-(difluoromethoxy)-5-[2- (dimethylphosphoryl)pyrimidin-5-yl]-12- methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 9 [00023] (1R,11R)-18-(difluoromethoxy)-5-{2- [(dimethylphosphoryl)methoxy] pyrimidin-5-yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 10 [00024] (1R,11R)-18-(difluoromethoxy)-5-{6- [(dimethylphosphoryl)methoxy]-5- fluoropyridin-3-yl}-12-methyl-2,9,12- triazapentacyclo [9.8.1.0{circumflex over ()} {2,10}.0{circumflex over ()} {3,8}.0{circumflex over ()} {14,19}] icosa- 3(8),4,6,9,14(19),15,17-heptaen-13-one 11 [00025] (1R,11R)-18-(difluoromethoxy)-5-{6- [(dimethylphosphoryl)methoxy]pyridin- 3-yl}-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 12 [00026] (1R,11R)-18-(difluoromethoxy)-5-(2- [(dimethylphosphoryl)methoxy]pyrimidin- 5-yl}-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 13 [00027] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)phenyl]-12-methyl- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 14 [00028] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3-fluorophenyl]- 12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 15 [00029] (7R,14R)-1-(difluoromethoxy)-11-(6- ((dimethylphosphoryl)methoxy)pyridin- 3-yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 16 [00030] (1R,11R)-18-(difluoromethoxy)-5-(6- {[(dimethylphosphoryl)methyl]amino}- 5-fluoropyridin-3-yl)-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 17 [00031] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)pyridin-3-yl)-6- (methyl-ds)-6,7-dihydro-7,14- methanobenzobenzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 18 [00032] (1R,11R)-18-(difluoromethoxy)-5-{4- [(dimethylphosphoryl)methoxy]-3- fluorophenyl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 19 [00033] (1R,11R)-18-(difluoromethoxy)-5-[6- (dimethylphosphoryl)pyridin-3-yl]-12- ethyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 20 [00034] (1R,11R)-18-(difluoromethoxy)-5-{6- [(dimethylphosphoryl)amino]pyridin-3- yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 21 [00035] (1R,11R)-18-(difluoromethoxy)-5-{1- [(dimethylphosphoryl)methyl]pyrazol-4- yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 22 [00036] (1R,11R)-18-(difluoromethoxy)-5-{6- [(dimethylphosphoryl)methyl]pyridin-3- yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{ 14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 23 [00037] (1R,11R)-18-(difluoromethoxy)-5-(6- {[(dimethylphosphoryl)methyl]amino} pyridin-3-yl)-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 24 [00038] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 25 [00039] (1R,11R)-18-(difluoromethoxy)-5-{2- [(dimethylphosphoryl)methoxy]-1,3- thiazol-5-yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 26 [00040] (1R,11R)-18-(difluoromethoxy)-5-{2- [(dimethylphosphoryl)amino]pyrimidin- 5-yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 27 [00041] (1R,11R)-5-[2-chloro-4- (dimethylphosphoryl)phenyl]-18- (difluoromethoxy)-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 28 [00042] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2-fluorophenyl]- 12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 29 [00043] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2-methylphenyl]- 12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 30 [00044] (1R,11R)-18-(difluoromethoxy)-5-(6- {[(dimethylphosphoryl)methyl](methyl) amino}pyridin-3-yl)-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 31 [00045] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2-fluorophenyl]- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 32 [00046] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2-methylphenyl]- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 33 [00047] (1R,11R)-18-(difluoromethoxy)-5-{4- [(dimethylphosphoryl)methyl]phenyl}- 12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 34 [00048] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2,3- difluorophenyl]-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 35 [00049] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3,5- difluorophenyl]-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 36 [00050] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2,3- difluorophenyl]-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 37 [00051] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3,5- difluorophenyl]-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 38 [00052] (1R,11R)-18-(difluoromethoxy)-5-14- [(dimethylphosphoryl)methoxy]phenyl}- 12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 39 [00053] (1R,11R)-18-(difluoromethoxy)-5-{6-[2- (dimethylphosphoryl)ethoxy]pyridin-3- yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 40 [00054] (1R,11R)-18-(difluoromethoxy)-5-{6-[3- (dimethylphosphoryl)propoxy]pyridin-3- yl}-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 41 [00055] (1R,11R)-5-[2-chloro-4- (dimethylphosphoryl)phenyl]-18- (difluoromethoxy)-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 42 [00056] (1R,11R)-18-(difluoromethoxy)-5-{2- [(dimethylphosphoryl)methoxy]-1,3- thiazol-5-yl}-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 43 [00057] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3-fluorophenyl]- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 44 [00058] (1R,11R)-18-(difluoromethoxy)-5-{4- [(dimethylphosphoryl)methoxy ]phenyl }- 12-cthyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 45 [00059] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3-fluorophenyl]- 12-ethyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 46 [00060] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3,5- difluorophenyl]-12-ethyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 47 [00061] (1R,11R)-12-cyclopropyl-18- (difluoromethoxy)-5-[6- (dimethylphosphoryl)pyridin-3-yl]- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 48 [00062] (1R,11R)-12-cyclopropyl-18- (difluoromethoxy)-5-[4- (dimethylphosphoryl)-3-fluorophenyl]- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 49 [00063] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)phenyl]-12-ethyl- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 50 [00064] (1R,11R)-18-(difluoromethoxy)-5-{4- [(dimethylphosphoryl)amino]phenyl}- 12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 51 [00065] (1R,11R)-5-[4-(diethylphosphoryl)-3- fluorophenyl]-18-(difluoromethoxy)- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 52 [00066] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2,3- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 53 [00067] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2-fluorophenyl)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 54 [00068] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2,5- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 55 [00069] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2,3- difluorophenyl]-6-fluoro-12-methyl- 2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 56 [00070] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2,5- difluorophenyl]-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 57 [00071] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-3-fluorophenyl]-6- fluoro-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 58 [00072] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2-fluorophenyl]-6- fluoro-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 59 [00073] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)- 10-fluoro-6-(methyl-d.sub.3)-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 60 [00074] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3,5- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 61 [00075] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2-fluorophenyl)- 10-fluoro-6-(methyl-d.sub.3)-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 62 [00076] (1R,11R)-18-(difluoromethoxy)-5-[4- (dimethylphosphoryl)-2,6- difluorophenyl]-12-methyl-2,9,12- triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}. 0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17- heptaen-13-one 63 [00077] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2,6- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 64 [00078] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)phenyl)-10-fluoro- 6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 65 [00079] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)phenyl)-6-(methyl- d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 66 [00080] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)- 10-fluoro-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 67 [00081] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-2- fluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 68 [00082] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3- fluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 69 [00083] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3,5- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 70 [00084] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)phenyl)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 71 [00085] (7R,14R)-11-(4-(dimethylphosphoryl)- 2,5-difluorophenyl)-1-hydroxy-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 72 [00086] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3- fluorophenyl)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 73 [00087] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-2,5- difluorophenyl)-6-methyl-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 74 [00088] (7R,14R)-11-(4-(dimethylphosphoryl)- 2,5-difluorophenyl)-1-methoxy-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 75 [00089] (7R,14R)-11-(4-(dimethylphosphoryl)- 2,5-difluorophenyl)-1-ethoxy-6-(methyl- d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 76 [00090] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-2,3- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 77 [00091] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3,5- difluorophenyl)-6-methyl-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 78 [00092] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3- fluorophenyl)-10-fluoro-6-(methyl-d.sub.3)- 6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 79 [00093] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3- fluorophenyl)-6-methyl-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 80 [00094] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-2- fluorophenyl)-6-methyl-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 81 [00095] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-3,5- difluorophenyl)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 82 [00096] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-2,5- difluorophenyl)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 83 [00097] dimethyl (4-((7R,14R)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-5-oxo- 5,6,7,14-tetrahydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-11- yl)benzyl)phosphonate 84 [00098] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)(hydroxy)methyl)p henyl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 85 and 86 [00099] (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1- (dimethylphosphoryl)ethyl)phenyl)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one And (7R,14R)-1-(difluoromethoxy)-11- (4-((R or S)-1- (dimethylphosphoryl)ethyl)phenyl)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one + [00100] 87 [00101] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-4-methylpyridin-3- yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 88 [00102] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-5-fluoro-2- methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 89 [00103] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-4-methylpyridin-3- yl)-10-fluoro-6-(methyl-d.sub.3)-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 90 [00104] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluoro-2- methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 91 [00105] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-2-methylpyridin-3- yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 92 [00106] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-2-fluoropyridin-3- yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 93 [00107] (7R,14R)-11-(4-chloro-6- (dimethylphosphoryl)pyridin-3-yl)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 94 [00108] (7R,14R)-11-(2-chloro-6- (dimethylphosphoryl)pyridin-3-yl)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 95 [00109] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)difluoromethyl)ph enyl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 96 [00110] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-2- fluorophenyl)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 97 [00111] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-2-methylpyridin-3- yl)-10-fluoro-6-(methyl-d.sub.3)-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 98 [00112] (7R,14R)-1-(difluoromethoxy)-11-(6- (((dimethylphosphoryl)methyl)amino) pyridin-3-yl)-6-(methyl-d.sub.3)-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 99 and 100 [00113] (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3- fluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one And (7R,14R)-1-(difluoromethoxy)-11- (4-((R or S)-1- (dimethylphosphoryl)ethyl)-3- fluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one + [00114] 101 [00115] (7R,14R)-11-(4- ((diethylphosphoryl)(hydroxy)methyl) phenyl)-1-(difluoromethoxy)-6-(methyl- d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 102 [00116] (7R,14R)-1-(difluoromethoxy)-11-(2- (difluoromethyl)-4- (dimethylphosphoryl)phenyl)-6-(methyl- d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 103 [00117] (7R,14R)-1-(difluoromethoxy)-11-(3- (difluoromethyl)-4- (dimethylphosphoryl)phenyl)-6-(methyl- d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 104 [00118] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2- (trifluoromethyl)phenyl)-6-(methyl-d.sub.3)- 6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 105 [00119] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-methylphenyl)- 6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 106 [00120] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluoro-5- methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 107 [00121] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2-fluoro-3- methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 108 [00122] (7R,14R)-1-(difluoromethoxy)-11-(4- ((dimethylphosphoryl)methyl)-5-fluoro- 2-methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 109 [00123] (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3,5- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 110 and 111 [00124] (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)-1- hydroxyethyl)phenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one And (7R,14R)-1-(difluoromethoxy)-11- (4-((R or S)-1-(dimethylphosphoryl)-1- hydroxyethyl)phenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one + [00125] 112 [00126] (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3,5- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 113 and 114 [00127] (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3- fluoro-2-methylphenyl)-6-(methyl-d.sub.3)- 6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one And (7R,14R)-1-(difluoromethoxy)-11- (4-((S or R)-1- (dimethylphosphoryl)ethyl)-3-fluoro-2- methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one + [00128] 115 [00129] (7R,14R)-1-(difluoromethoxy)-11-(5- (dimethylphosphoryl)-6-fluoropyridin-2- yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 116 [00130] (7R,14R)-1-(difluoromethoxy)-11-(6-(1- (dimethylphosphoryl)ethyl)pyridin-3-yl)- 6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 117 [00131] (7R,14R)-11-(3-chloro-4- (dimethylphosphoryl)phenyl)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 118 and 119 [00132] (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-5- fluoro-2-methylphenyl)-6-(methyl-d.sub.3)- 6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one And (7R,14R)-1-(difluoromethoxy)-11- (4-((S or R)-1- (dimethylphosphoryl)ethyl)-5-fluoro-2- methylphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one + [00133] 120 [00134] (7R,14R)-1-(difluoromethoxy)-11-(6-(2- (dimethylphosphoryl)propan-2- yl)pyridin-3-yl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 121 [00135] (7R,14R)-11-(6-chloro-5- (dimethylphosphoryl)pyridin-2-yl)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 122 [00136] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3- (trifluoromethyl)phenyl)-6-(methyl-d.sub.3)- 6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 123 [00137] (7R,14R)-1-(difluoromethoxy)-11-(5- (dimethylphosphoryl)-4-fluoro-6- methylpyridin-2-yl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 124 [00138] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-5-fluoropyridin-3- yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 125 [00139] (7R,14R)-11-(4-(diethylphosphoryl)-3- fluorophenyl)-1-(difluoromethoxy)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 126 [00140] (7R,14R)-11-(6- (diethylphosphoryl)pyridin-3-yl)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 127 [00141] (7R,14R)-11-(6-(diethylphosphory])-5- fluoropyridin-3-yl)-1-(difluoromethoxy)- 6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 128 [00142] (7R,14R)-11-(4-(dimethylphosphoryl)-3- fluorophenyl)-6-(methyl-d.sub.3)-1- (trifluoromethoxy)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 129 [00143] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluoro-5- methoxyphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 130 [00144] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-5-fluoro-2- methoxyphenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 131 [00145] (7R,14R)-11-(3-amino-4- (dimethylphosphoryl)-5-fluorophenyl)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 132 [00146] (7R,14R)-1-(difluoromethoxy)-11-(5- (dimethylphosphoryl)-6-fluoro-4- methylpyridin-2-yl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 133 [00147] 5-((7R,14R)-1-(difluoromethoxy)-6- (methyl-d.sub.3)-5-oxo-5,6,7,14-tetrahydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-11-yl)-2- (dimethylphosphoryl)-3- fluorobenzonitrile 134 [00148] (7R,14R)-1-(difluoromethoxy)-11-(6- (dimethylphosphoryl)-5-methylpyridin-3- yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 135 [00149] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)-9- fluoro-6-(methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 136 [00150] dimethyl (4-((7R,14R)-1- (difluoromethoxy)-6-(methyl-d.sub.3)-5-oxo- 5,6,7,14-tetrahydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-11-yl)-2- fluorobenzyl)phosphonate 137 [00151] (7R,14R)-11-(6- (diethylphosphoryl)pyridin-3-yl)-1- (difluoromethoxy)-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 138 [00152] (7R,14R)-11-(4-(diethylphosphoryl)-2- fluorophenyl)-1-(difluoromethoxy)-6,7- dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 139 [00153] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)- 12-fluoro-6-(methyl-d.sub.3)-6,7-dihydro- 7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 140 [00154] (7R,14R)- 1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)- 12-fluoro-6,7-dihydro-7,14- methanobenzo[f]benzo[4,5]imidazo[1,2- a][1,4]diazocin-5(14H)-one 141 [00155] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-3-fluorophenyl)-6- (methyl-d.sub.3)-6,7-dihydro-7,14- methanobenzo[f]pyrido[3,2:4,5]imidazo [1,2-a][1,4]diazocin-5(14H)-one 142 [00156] (7R,14R)-1-(difluoromethoxy)-11-(4- (dimethylphosphoryl)-2,5- difluorophenyl)-6-(methyl-d.sub.3)-6,7- dihydro-7,14- methanobenzo[f]pyrido[3,2:4,5]imidazo [1,2-a][1,4]diazocin-5(14H)-one

[0168] Another embodiment provides a TNF? inhibitory compound, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, having a structure presented in Table 2.

TABLE-US-00002 TABLE 2 [00157] [00158] [00159] [00160] [00161] [00162] [00163] [00164] [00165] [00166] [00167] [00168] [00169]

[0169] Preparation of Compounds

[0170] The compounds used in the synthetic chemistry reactions described herein are made according to organic synthesis techniques known to those skilled in this art, starting from commercially available chemicals and/or from compounds described in the chemical literature. Commercially available chemicals are obtained from standard commercial sources including Acros Organics (Pittsburgh, PA), Aldrich Chemical (Milwaukee, WI, including Sigma Chemical and Fluka), Apin Chemicals Ltd. (Milton Park, UK), Avocado Research (Lancashire, U.K.), BDH Inc. (Toronto, Canada), Bionet (Cornwall, U.K.), Chemservice Inc. (West Chester, PA), Crescent Chemical Co. (Hauppauge, NY), Eastman Organic Chemicals, Eastman Kodak Company (Rochester, NY), Fisher Scientific Co. (Pittsburgh, PA), Fisons Chemicals (Leicestershire, UK), Frontier Scientific (Logan, UT), ICN Biomedicals, Inc. (Costa Mesa, CA), Key Organics (Cornwall, U.K.), Lancaster Synthesis (Windham, NH), Maybridge Chemical Co. Ltd. (Cornwall, U.K.), Parish Chemical Co. (Orem, UT), Pfaltz & Bauer, Inc. (Waterbury, CN), Polyorganix (Houston, TX), Pierce Chemical Co. (Rockford, IL), Riedel de Haen AG (Hanover, Germany), Spectrum Quality Product, Inc. (New Brunswick, NJ), TCI America (Portland, OR), Trans World Chemicals, Inc. (Rockville, MD), and Wako Chemicals USA, Inc. (Richmond, VA).

[0171] Suitable reference books and treatise that detail the synthesis of reactants useful in the preparation of compounds described herein, or provide references to articles that describe the preparation, include for example, Synthetic Organic Chemistry, John Wiley & Sons, Inc., New York; S. R. Sandler et al., Organic Functional Group Preparations, 2nd Ed., Academic Press, New York, 1983; H. O. House, Modern Synthetic Reactions, 2nd Ed., W. A. Benjamin, Inc. Menlo Park, Calif. 1972; T. L. Gilchrist, Heterocyclic Chemistry, 2nd Ed., John Wiley & Sons, New York, 1992; J. March, Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 4th Ed., Wiley-Interscience, New York, 1992. Additional suitable reference books and treatise that detail the synthesis of reactants useful in the preparation of compounds described herein, or provide references to articles that describe the preparation, include for example, Fuhrhop, J. and Penzlin G. Organic Synthesis: Concepts, Methods, Starting Materials, Second, Revised and Enlarged Edition (1994) John Wiley & Sons ISBN: 3-527-29074-5; Hoffman, R. V. Organic Chemistry, An Intermediate Text (1996) Oxford University Press, ISBN 0-19-509618-5; Larock, R. C. Comprehensive Organic Transformations: A Guide to Functional Group Preparations 2nd Edition (1999) Wiley-VCH, ISBN: 0-471-19031-4; March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure 4th Edition (1992) John Wiley & Sons, ISBN: 0-471-60180-2; Otera, J. (editor) Modern Carbonyl Chemistry (2000) Wiley-VCH, ISBN: 3-527-29871-1; Patai, S. Patai's 1992 Guide to the Chemistry of Functional Groups (1992) Interscience ISBN: 0-471-93022-9; Solomons, T. W. G. Organic Chemistry 7th Edition (2000) John Wiley & Sons, ISBN: 0-471-19095-0; Stowell, J. C., Intermediate Organic Chemistry 2nd Edition (1993) Wiley-Interscience, ISBN: 0-471-57456-2; Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia (1999) John Wiley & Sons, ISBN: 3-527-29645-X, in 8 volumes; Organic Reactions (1942-2000) John Wiley & Sons, in over 55 volumes; and Chemistry of Functional Groups John Wiley & Sons, in 73 volumes.

[0172] Specific and analogous reactants are optionally identified through the indices of known chemicals prepared by the Chemical Abstract Service of the American Chemical Society, which are available in most public and university libraries, as well as through on-line databases (contact the American Chemical Society, Washington, D.C. for more details). Chemicals that are known but not commercially available in catalogs are optionally prepared by custom chemical synthesis houses, where many of the standard chemical supply houses (e.g., those listed above) provide custom synthesis services. A reference useful for the preparation and selection of pharmaceutical salts of the compounds described herein is P. H. Stahl & C. G. Wermuth Handbook of Pharmaceutical Salts, Verlag Helvetica Chimica Acta, Zurich, 2002.

[0173] Pharmaceutical Compositions

[0174] In certain embodiments, the TNF? inhibitory compound described herein is administered as a pure chemical. In other embodiments, the TNF? inhibitory compound described herein is combined with a pharmaceutically suitable or acceptable carrier (also referred to herein as a pharmaceutically suitable (or acceptable) excipient, physiologically suitable (or acceptable) excipient, or physiologically suitable (or acceptable) carrier) selected on the basis of a chosen route of administration and standard pharmaceutical practice as described, for example, in Remington: The Science and Practice of Pharmacy (Gennaro, 21.sup.st Ed. Mack Pub. Co., Easton, PA (2005)).

[0175] Provided herein is a pharmaceutical composition comprising at least one TNF? inhibitory compound as described herein, or pharmaceutically acceptable salt, solvate, or N-oxide thereof, together with one or more pharmaceutically acceptable carriers. The carrier(s) (or excipient(s)) is acceptable or suitable if the carrier is compatible with the other ingredients of the composition and not deleterious to the recipient (i.e., the subject or the patient) of the composition.

[0176] One embodiment provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of Formula (I) or (Ia), or pharmaceutically acceptable salt, solvate, or N-oxide thereof.

[0177] One embodiment provides a method of preparing a pharmaceutical composition comprising mixing a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, and a pharmaceutically acceptable carrier.

[0178] In certain embodiments, the TNF? inhibitory compound as described by Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, is substantially pure, in that it contains less than about 5%, or less than about 2%, or less than about 1%, or less than about 0.5%, or less than about 0.1%, of other organic small molecules, such as unreacted intermediates or synthesis by-products that are created, for example, in one or more of the steps of a synthesis method.

[0179] One embodiment provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof.

[0180] One embodiment provides a method of preparing a pharmaceutical composition comprising mixing a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, and a pharmaceutically acceptable carrier.

[0181] In certain embodiments, the TNF? inhibitory compound as described by Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, is substantially pure, in that it contains less than about 5%, or less than about 2%, or less than about 1%, or less than about 0.5%, or less than about 0.1%, of other organic small molecules, such as unreacted intermediates or synthesis by-products that are created, for example, in one or more of the steps of a synthesis method.

[0182] Suitable oral dosage forms include, for example, tablets, pills, sachets, or capsules of hard or soft gelatin, methylcellulose or of another suitable material easily dissolved in the digestive tract. In some embodiments, suitable nontoxic solid carriers are used which include, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin, talcum, cellulose, glucose, sucrose, magnesium carbonate, and the like. (See, e.g., Remington: The Science and Practice of Pharmacy (Gennaro, 21.sup.st Ed. Mack Pub. Co., Easton, PA (2005)).

[0183] In some embodiments, the TNF? inhibitory compound as described by Formula (I) or (Ia) or Table 1 or Table 2, or pharmaceutically acceptable salt or solvate thereof, is formulated for administration by injection. In some instances, the injection formulation is an aqueous formulation. In some instances, the injection formulation is a non-aqueous formulation. In some instances, the injection formulation is an oil-based formulation, such as sesame oil, or the like.

[0184] The dose of the composition comprising at least one TNF? inhibitory compound as described herein differs depending upon the subject or patient's (e.g., human) condition. In some embodiments, such factors include general health status, age, and other factors.

[0185] Pharmaceutical compositions are administered in a manner appropriate to the disease to be treated (or prevented). An appropriate dose and a suitable duration and frequency of administration will be determined by such factors as the condition of the patient, the type and severity of the patient's disease, the particular form of the active ingredient, and the method of administration. In general, an appropriate dose and treatment regimen provides the composition(s) in an amount sufficient to provide therapeutic and/or prophylactic benefit (e.g., an improved clinical outcome, such as more frequent complete or partial remissions, or longer disease-free and/or overall survival, or a lessening of symptom severity. Optimal doses are generally determined using experimental models and/or clinical trials. The optimal dose depends upon the body mass, weight, or blood volume of the patient.

[0186] Oral doses typically range from about 1.0 mg to about 1000 mg, one to four times, or more, per day.

[0187] Methods of Treatment

[0188] One embodiment provides a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, for use in a method of treatment of the human or animal body.

[0189] One embodiment provides a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, for use in a method of treatment of inflammatory or autoimmune disease or disorder. Another embodiment provides a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, for use in a method of treatment of inflammatory disease or disorder. Yet another embodiment provides a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, for use in a method of treatment of autoimmune disease or disorder.

[0190] One embodiment provides a pharmaceutical composition comprising a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, and a pharmaceutically acceptable excipient for use in a method of treatment of inflammatory or autoimmune disease or disorder.

[0191] One embodiment provides a use of a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, in the manufacture of a medicament for the treatment of inflammatory or autoimmune disease or disorder.

[0192] In some embodiments is provided a method of treating an inflammatory or autoimmune disease or disorder, in a patient in need thereof, comprising administering to the patient a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof. In some embodiments is provided a method of treating inflammatory or autoimmune disease or disorder, in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, and a pharmaceutically acceptable excipient. One embodiment provides a method of treating an inflammatory disease or disorder. Another embodiment provides a method of treating an autoimmune disease or disorder.

[0193] One embodiment provides a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, for use in a method of treatment of the human or animal body.

[0194] One embodiment provides a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, for use in a method of treatment of inflammatory or autoimmune disease or disorder.

[0195] One embodiment provides a pharmaceutical composition comprising a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, and a pharmaceutically acceptable excipient for use in a method of treatment of inflammatory or autoimmune disease or disorder.

[0196] One embodiment provides a use of a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, in the manufacture of a medicament for the treatment of inflammatory or autoimmune disease or disorder.

[0197] In some embodiments is provided a method of treating an inflammatory or autoimmune disease or disorder in a patient in need thereof, comprising administering to the patient a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof. In some embodiments is provided a method of treating an inflammatory or autoimmune disease or disorder, in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising a compound of Table 1 or Table 2, or a pharmaceutically acceptable salt, solvate, or N-oxide thereof, and a pharmaceutically acceptable excipient.

[0198] In some embodiments the inflammatory and autoimmune disease or disorder is selected from, but are not limited to: rheumatoid arthritis, psoriatic arthritis, systemic onset juvenile idiopathic arthritis, multiple sclerosis, lupus nephritis, systemic lupus erythematosus, psoriasis, Crohn's disease, colitis, asthma, graft versus host disease, allograft rejection, chronic obstructive pulmonary disease, multiple sclerosis, Alzheimer's disease, Graves' disease, cutaneous lupus, ankylosing spondylitis, cryopyrin-associated periodic syndromes (CAPS), gout, and gouty arthritis, ulcerative TNF receptor associated periodic syndrome (TRAPS), Wegener's granulomatosis, sarcoidosis, familial Mediterranean fever (FMF), neuropathic pain, and adult onset stills.

[0199] Provided herein is the method wherein the pharmaceutical composition is administered orally. Provided herein is the method wherein the pharmaceutical composition is administered by injection.

[0200] One embodiment provides a method of inhibiting TNF? activity comprising contacting the TNF? protein with a compound of Formula (I) or (Ia) or Table 1 or Table 2. Another embodiment provides the method of inhibiting TNF? activity, wherein the TNF? protein is contacted in an in vivo setting. Another embodiment provides the method of inhibiting TNF? activity, wherein the TNF? protein is contacted in an in vitro setting.

[0201] Other embodiments and uses will be apparent to one skilled in the art in light of the present disclosures. The following examples are provided merely as illustrative of various embodiments and shall not be construed to limit the invention in any way.

EXAMPLES

[0202] I. Chemical Synthesis

[0203] In some embodiments, the TNF? inhibitory compounds disclosed herein are synthesized according to the following examples. As used below, and throughout the description of the invention, the following abbreviations, unless otherwise indicated, shall be understood to have the following meanings: [0204] ACN acetonitrile [0205] ? C. degrees Celsius [0206] ?.sub.H chemical shift in parts per million downfield from tetramethylsilane [0207] DCM dichloromethane (CH.sub.2Cl.sub.2) [0208] DIAD diisopropyl azodicarboxylate [0209] DIEA diisopropylethylamine [0210] DMF dimethylformamide [0211] DMSO dimethylsulfoxide [0212] EA ethyl acetate [0213] EtOAc ethyl acetate [0214] ESI electrospray ionization [0215] Et ethyl [0216] g gram(s) [0217] h hour(s) [0218] HPLC high performance liquid chromatography [0219] Hz hertz [0220] J coupling constant (in NMR spectrometry) [0221] LCMS liquid chromatography mass spectrometry [0222] ? micro [0223] m multiplet (spectral); meter(s); milli [0224] M molar [0225] M.sup.+ parent molecular ion [0226] Me methyl [0227] MsCl methanesulfonyl chloride [0228] MHz megahertz [0229] min minute(s) [0230] mol mole(s); molecular (as in mol wt) [0231] mL milliliter [0232] MS mass spectrometry [0233] nm nanometer(s) [0234] NMR nuclear magnetic resonance [0235] pH potential of hydrogen; a measure of the acidity or basicity of an aqueous solution [0236] PE petroleum ether [0237] RT room temperature [0238] s singlet (spectral) [0239] t triplet (spectral) [0240] SFC Supercritical fluid chromatography [0241] T temperature [0242] TFA trifluoroacetic acid [0243] THF tetrahydrofuran [0244] TPP Triphenylphosphine

Example 1: (7R,14R)-1-(difluoromethoxy)-11-(2-(dimethylphosphoryl)pyrimidin-5-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0245] ##STR00170##

##STR00171## ##STR00172##

Preparation 1A: 2-bromo-6-(difluoromethoxy)benzaldehyde

[0246] ##STR00173##

[0247] To a stirred solution of 2-bromo-6-hydroxybenzaldehyde (90.00 g, 447.719 mmol) in 1,4-dioxane (900 mL) was added the solution of NaOH (107.44 g, 2686.314 mmol) in H.sub.2O (900 mL) dropwise at room temperature. The mixture was heated at 65? C. and chlorodifluoromethane (gas) was passed through the solution. The reaction mixture was allowed to cool down to room temperature. The resulting mixture was filtered, and the filter cake was washed with EtOAc (3?100 mL). The filtrate was extracted with EtOAc (3?500 mL). The combined organic layers were dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (20:1) to afford 2-bromo-6-(difluoromethoxy)benzaldehyde (80.00 g, 71%) as a yellow oil. .sup.1H NMR (300 MHz, Chloroform-d) ? 10.35 (s, 1H), 7.58 (d, J=8.1 Hz, 1H), 7.41 (t, J=8.1 Hz, 1H), 7.26 (d, J=7.9 Hz, 1H), 6.61 (t, J=73.4 Hz, 1H).

Preparation 1B: (S)N-{[2-bromo-6-(difluoromethoxy)phenyl]methylidene}-2-methylpropane-2-sulfinamide

[0248] ##STR00174##

[0249] To a stirred solution of 2-bromo-6-(difluoromethoxy)benzaldehyde (80.00 g, 318.691 mmol) and (S)-2-methylpropane-2-sulfinamide (38.63 g, 318.691 mmol) in CH.sub.2Cl.sub.2 (800 mL) was added Cs.sub.2CO.sub.3 (207.67 g, 637.382 mmol) at room temperature. The resulting mixture was stirred for 16 h at room temperature. The resulting mixture was diluted with water (1 L). The resulting mixture was extracted with EtOAc (3?500 mL). The combined organic layers were washed with brine (1?1 L), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (10:1) to afford (S)N-{[2-bromo-6-(difluoromethoxy)phenyl]methylidene}-2-methylpropane-2-sulfinamide (90.00 g, 80%) as a yellow oil. MS ESI calculated for C.sub.12H.sub.14BrF.sub.2NO.sub.2S [M+H].sup.+ 353.99 355.99, found 353.80 355.75. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.84 (s, 1H), 7.59-7.57 (m, 1H), 7.35-7.31 (m, 1H), 7.26-7.24 (m, 1H), 6.57 (t, J=73.8 Hz, 1H), 1.30 (s, 9H).

Preparation 1C: ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-([(S)-2-methylpropane-2-sulfinyl]amino propanoate

[0250] ##STR00175##

[0251] To a stirred mixture of Zn powder (36.92 g, 564.640 mmol) in THF (200 mL) was added anhydrous CuCl (5.59 g, 56.464 mmol) at room temperature. The resulting mixture was stirred for 0.5 h at 70? C. The mixture was allowed to cool down to room temperature. To the above mixture was added solution of ethyl bromoacetate (23.57 g, 141.160 mmol) in THF (200 mL) dropwise at room temperature. The resulting mixture was stirred for additional 0.5 h at 50? C. The resulting mixture was filtered. To the above filtrate was added solution of (S)N-{[2-bromo-6-(difluoromethoxy)phenyl]methylidene}-2-methylpropane-2-sulfinamide (20.00 g, 56.464 mmol) in THF (20 mL) dropwise at 0? C. The resulting mixture was stirred for additional 2 h at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at room temperature. The resulting mixture was filtered, and the filter cake was washed with ethyl acetate (3?100 mL). The filtrate was extracted with EtOAc (3?200 mL). The combined organic layers were washed with brine (1?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-{[(S)-2-methylpropane-2-sulfinyl]amino}propanoate (21.00 g, 84%) as a yellow oil. MS ESI calculated for C.sub.16H.sub.22BrF.sub.2NO.sub.4S [M+H].sup.+ 442.04 444.4, 441.90 443.90. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.50-7.42 (m, 1H), 7.23-7.00 (m, 2H), 6.62 (t, J=73.0 Hz, 1H), 5.68-5.55 (m, 1H), 4.18-4.03 (m, 2H), 3.36-2.92 (m, 2H), 1.22 (t, J=7.0 Hz, 3H), 1.16 (s, 9H).

Preparation 1D: ethyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate hydrochloride

[0252] ##STR00176##

[0253] To a stirred solution of ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-([(S)-2-methylpropane-2-sulfinyl]amino)propanoate (24.00 g, 54.259 mmol) in Et.sub.2O (50 mL) and EtOH (25 mL) was added 4N HCl (gas) in 1,4-dioxane (70 mL) at room temperature. The resulting mixture was stirred for 3 h at room temperature. The resulting mixture was concentrated under reduced pressure. This resulting in ethyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate hydrochloride (20.00 g, 98%) as a yellow oil. MS ESI calculated for C.sub.12H.sub.14BrF.sub.2NO.sub.3 [M+H].sup.+ 338.01 340.01, found 338.00 340.00.

Preparation 1E: ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-2-nitrophenyl)amino]propanoate

[0254] ##STR00177##

[0255] To a stirred solution of ethyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate hydrochloride (20.00 g, 53.389 mmol) and 4-chloro-2-fluoro-1-nitrobenzene (11.25 g, 64.067 mmol) in ACN (200 mL) was added potassium carbonate (22.30 g, 160.167 mmol) at room temperature. The mixture was stirred for 16 h at 80? C. The resulting mixture was diluted with water (200 mL), and extracted with EtOAc (3?500 mL). The combined organic layers were washed with brine (1?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (10:1) to afford ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-2-nitrophenyl)amino]propanoate (20.00 g, 76%) as a yellow oil. MS ESI calculated for C.sub.18H.sub.16BrClF.sub.2N.sub.2O.sub.5 [M+H].sup.+ 492.99 494.99, found 492.95 494.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.92 (d, J=8.8 Hz, 1H), 8.08 (d, J=9.1 Hz, 1H), 7.48-7.43 (m, 1H), 7.23-7.11 (m, 2H), 7.11-7.04 (m, 1H), 6.65 (t, J=73.0 Hz, 1H), 6.63-6.57 (m, 1H), 5.87-5.77 (m, 1H), 4.18-4.09 (m, 2H), 3.23-3.17 (m, 1H), 3.02-2.85 (m, 1H), 1.22 (t, J=7.1 Hz, 3H).

Preparation 1F: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-2-nitrophenyl)amino]propanal

[0256] ##STR00178##

[0257] To a stirred solution of ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-2-nitrophenyl)amino]propanoate (18.00 g, 36.460 mmol) in CH.sub.2Cl.sub.2 (200 mL) was added 1N DIBAl-H (73 mL, 73.000 mmol) in THF dropwise at ?78? C. under nitrogen atmosphere. The reaction was stirred for 3 h at ?78? C. under nitrogen atmosphere. The resulting mixture was quenched with sat. NH.sub.4Cl (aq.) at ?78? C., and extracted with CH.sub.2Cl.sub.2 (3?500 mL). The combined organic layers were dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (10:1) to afford (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-2-nitrophenyl)amino]propanal (12.00 g, 73%) as a yellow oil. MS ESI calculated for C.sub.16H.sub.12BrClF.sub.2N.sub.2O.sub.4 [M+H].sup.+ 448.96 450.96, found 448.95 450.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.81 (s, 1H), 8.84 (d, J=9.0 Hz, 1H), 8.08 (d, J=9.1 Hz, 1H), 7.49-7.43 (m, 1H), 7.22-7.14 (m, 2H), 7.13-7.06 (m, 1H), 6.67 (t, J=73.0 Hz, 1H), 6.65-6.60 (m, 1H), 5.97-5.88 (m, 1H), 3.56-3.41 (m, 1H), 3.22-2.93 (m, 1H).

Preparation 1G: (4R)-4-[2-bromo-6-(difluoromethoxy)phenyl]-4-[(5-chloro-2-nitrophenyl)amino]-2-[(trimethylsilyl)oxy]butanenitrile

[0258] ##STR00179##

To a stirred solution of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-2-nitrophenyl)amino]propanal (12.00 g, 26.689 mmol) in CH.sub.2Cl.sub.2 (120 mL) were added ZnI.sub.2 (852 mg, 2.669 mmol) and TMSCN (5.30 g, 53.378 mmol) at room temperature. The mixture was stirred for 16 h at room temperature. The resulting mixture was diluted with water (50 mL), and extracted with CH.sub.2Cl.sub.2 (3?50 mL). The combined organic layers were dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford (4R)-4-[2-bromo-6-(difluoromethoxy)phenyl]-4-[(5-chloro-2-nitrophenyl)amino]-2-[(trimethylsilyl)oxy]butanenitrile (13.00 g, 89%) as a yellow oil. The crude product was used in the next step directly without further purification. MS ESI calculated for C.sub.20H.sub.21BrClF.sub.2N.sub.3O.sub.4Si [M+H].sup.+ 548.01 550.01, found 548.05 550.00.

Preparation 1H: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol

[0259] ##STR00180##

[0260] To a stirred solution of (4R)-4-[2-bromo-6-(difluoromethoxy)phenyl]-4-[(5-chloro-2-nitrophenyl)amino]-2-[(trimethylsilyl)oxy]butanenitrile (13.00 g, 23.686 mmol) in EtOH (100 mL) was added SnCl.sub.2.Math.2H.sub.2O (26.96 g, 118.430 mmol) at room temperature. The mixture was stirred for 16 h at 80? C. The reaction was quenched by the addition of water (50 mL) at room temperature, and basified to pH 8 with 1N KOH (aq.). The mixture was filtered, the filter cake was washed with EtOAc (3?50 mL), and extracted with EtOAc (3?100 mL). The combined organic layers were washed with brine (1?100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (1:2) to afford (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol (7.00 g, 69%) as a yellow solid. MS ESI calculated for C.sub.17H.sub.12BrClF.sub.2N.sub.2O.sub.2 [M+H].sup.+ 428.97 430.97, found 429.00 431.00.

Preparation 1I: (3R)-5-azido-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraene

[0261] ##STR00181##

[0262] To a stirred solution of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol (22.00 g, 51.204 mmol) in THF (200 mL) were added DPPA (16.91 g, 61.445 mmol) and DBU (15.59 g, 102.408 mmol) at 0? C. The mixture was stirred for 16 h at room temperature. The resulting mixture was extracted with EtOAc (3?500 mL). The combined organic layers were washed with brine (1?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20:1) to afford desired mixture of (3R)-5-azido-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraene (15.00 g, 64%) as a green oil. MS ESI calculated for C.sub.17H.sub.11BrClF.sub.2N.sub.5O [M+H].sup.+ 453.98 455.98, found 454.05 456.05.

[0263] Preparation 1J: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine

##STR00182##

[0264] To a stirred solution of (3R)-5-azido-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraene (15.00 g, 32.992 mmol) in THF (50 mL) and H.sub.2O (5 mL) was added PPh.sub.3 (12.98 g, 49.488 mmol) at room temperature. The mixture was stirred for 16 h at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12:1) to afford (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (10 g, 71%) as a yellow solid. MS ESI calculated for C.sub.17H.sub.13BrClF.sub.2N.sub.3O [M+H].sup.+ 427.99 429.99, found 428.00 430.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.70-7.58 (m, 2H), 7.35-7.28 (m, 1H), 7.23-7.00 (m, 2H), 6.90-6.46 (m, 1H), 6.17-6.06 (m, 1H), 5.98-5.58 (m, 1H), 4.77-4.57 (m, 1H), 3.60-3.40 (m 1H), 2.82-2.55 (m, 1H).

Preparation 1K: (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0265] ##STR00183##

[0266] To a solution of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (500 mg, 1.166 mmol) in 1,4-dioxane (10 mL) were added K.sub.2CO.sub.3 (806 mg, 5.830 mmol), XantPhos (34 mg, 0.058 mmol) and Pd(OAc).sub.2 (13 mg, 0.058 mmol) in a pressure tank. The mixture was purged with nitrogen for 5 min and then was pressurized to 1 atm with carbon monoxide at 100? C. for 16 h. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (200 mg, 46%) as a white solid. MS ESI calculated for C.sub.18H.sub.12ClF.sub.2N.sub.3O.sub.2 [M+H].sup.+ 376.06, found 375.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.44 (d, J=8.0 Hz, 1H), 7.64 (d, J=8.7 Hz, 1H), 7.52-7.35 (m, 4H), 7.24-7.19 (m, 1H), 6.85 (t, J=72.6 Hz, 1H), 6.29 (d, J=7.3 Hz, 1H), 4.94 (t, J=6.6 Hz, 1H), 3.53-3.41 (m, 1H), 2.85 (d, J=13.3 Hz, 1H).

Preparation 1L: (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptan-13-one

[0267] ##STR00184##

[0268] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.133 mmol) and BPD (51 mg, 0.200 mmol) in 1,4-dioxane (2 mL) were added KOAc (39 mg, 0.399 mmol), Pd.sub.2(dba).sub.3 (12 mg, 0.013 mmol) and PCy.sub.3.Math.HBF.sub.4 (5 mg, 0.013 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 140? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (22 mg, 35%) as a yellow oil. MS ESI calculated for C.sub.24H.sub.24BF.sub.2N.sub.3O.sub.4 [M+H].sup.+ 468.18, found 467.95.

Example 1: (7R,14R)-1-(difluoromethoxy)-11-(2-(dimethylphosphoryl)pyrimidin-5-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0269] ##STR00185##

[0270] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (22 mg, 0.047 mmol) and 5-bromo-2-(dimethylphosphoryl)pyrimidine (11 mg, 0.047 mmol) in 1,4-dioxane (2 mL) was added solution of K.sub.3PO.sub.4 (30 mg, 0.141 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above mixture was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (4 mg, 0.005 mmol) at room temperature. The resulting mixture was stirred for 2 h at 100? C. under nitrogen atmosphere. The solution was purified by Prep-HPLC to afford (1R,11R)-18-(difluoromethoxy)-5-[2-(dimethylphosphoryl)pyrimidin-5-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (15 mg, 64%) as a white solid. MS ESI calculated for C.sub.24H.sub.20F.sub.2N.sub.5O.sub.3P [M+H].sup.+ 496.13, found 496.20. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 9.24 (s, 2H), 9.16 (d, J=6.8 Hz, 1H), 8.26-8.21 (m, 1H), 7.89-7.66 (m, 4H), 7.52-7.50 (m, 2H), 6.39-6.38 (m, 1H), 4.93-4.90 (m, 1H), 3.53-3.46 (m, 1H), 2.78-2.75 (m, 1H), 1.83 (s, 3H), 1.80 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.53 (d, J=169.3 Hz) (1F), ?82.84 (d, J=169.3 Hz) (1F). .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 33.89.

Example 2: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)pyridin-3-yl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0271] ##STR00186##

Preparation 2A: (1R,11R)-5-chloro-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0272] ##STR00187##

[0273] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (120 mg, 0.319 mmol) in dry THF (2 mL) was added 1N KHMDS (0.4 mL, 0.40 mmol) in THF dropwise at ?78? C. under nitrogen atmosphere. This reaction was stirred for 1 h at ?78? C. under nitrogen atmosphere. To the above solution was added CH.sub.3I (68 mg, 0.479 mmol) dropwise over 2 min at ?78? C. The mixture was stirred for 1 h at room temperature. The reaction was quenched by the addition of sat. NH.sub.4Cl (aq.) (1 mL) at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-5-chloro-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (85 mg, 68%) as a yellow solid. MS ESI calculated for C.sub.19H.sub.14ClF.sub.2N.sub.3O.sub.2 [M+H].sup.+ 390.07 392.07, found 390.25 392.25. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.65 (d, J=8.7 Hz, 1H), 7.48-7.42 (m, 2H), 7.38-7.32 (m, 1H), 7.25-7.22 (m, 1H), 6.84 (t, J=72.6 Hz, 1H), 6.24-6.21 (m, 1H), 5.02-5.00 (m, 1H), 3.53 (s, 3H), 3.49-3.41 (m, 1H), 2.90-2.86 (m, 1H).

Preparation 2B: (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0274] ##STR00188##

[0275] To a stirred mixture of (1R,11R)-5-chloro-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (85 mg, 0.218 mmol), KOAc (64 mg, 0.654 mmol) and BPD (83 mg, 0.327 mmol) in 1,4-dioxane (3 mL) were added PCy.sub.3.Math.HBF.sub.4 (8 mg, 0.022 mmol) and Pd.sub.2(dba).sub.3 (20 mg, 0.022 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 140? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (65 mg, 62%) as a yellow oil. MS ESI calculated for C.sub.25H.sub.26BF.sub.2N.sub.3O.sub.4 [M+H].sup.+ 482.20, found 481.90.

Example 2: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)pyridin-3-yl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0276] ##STR00189##

[0277] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.125 mmol) and 5-bromo-2-(dimethylphosphoryl)pyridine (29 mg, 0.125 mmol) in 1,4-dioxane (3 mL) was added a solution of K.sub.3PO.sub.4 (79 mg, 0.375 mmol) in H.sub.2O (1 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 100? C. The solution was purified by reversed-phase flash chromatography (C18 Column 120 g; Mobile Phase A: water (10 mmol/L, FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20% B to 40% B in 25 min; 254/220 nm) and the fractions containing the desired product were collected at 33% B, concentrated under reduced pressure to afford (1R,11R)-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (40 mg, 63%) as an off-white solid. MS ESI calculated for C.sub.26H.sub.23F.sub.2N.sub.4O.sub.3P [M+H].sup.+ 509.15, found 509.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.97-8.92 (m, 1H), 8.52-8.47 (m, 1H), 8.22-8.15 (m, 1H), 8.05-7.99 (m, 1H), 7.84 (d, J=8.5 Hz, 1H), 7.76-7.72 (m, 1H), 7.54-7.47 (m, 1H), 7.46-7.41 (m, 1H), 7.34-7.29 (m, 1H), 6.86 (t, J=72.9 Hz, 1H), 6.31 (d, J=7.1 Hz, 1H), 5.02 (d, J=7.0 Hz, 1H), 3.54 (s, 3H), 3.53-3.45 (m, 1H), 2.91 (d, J=13.6 Hz, 1H), 1.84 (s, 3H), 1.81 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.73 (2F). .sup.31P NMR (162 MHz, Chloroform-d) ? 36.56.

Example 3: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)pyridin-3-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0278] ##STR00190##

[0279] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.107 mmol) and 5-bromo-2-(dimethylphosphoryl)pyridine (25 mg, 0.107 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (68 mg, 0.321 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above mixture was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 100? C. The resulting mixture was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography (C18 Column 40 g; Mobile Phase A: water (10 mmol/L, FA), Mobile Phase B: CH.sub.3CN; Flow rate. 25 mL/min; Gradient: 20% B to 40% B in 30 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (25 mg, 47%) as a white solid. MS ESI calculated for C.sub.25H.sub.21F.sub.2N.sub.4O.sub.3P [M+H].sup.+ 495.13, found 495.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.95 (d, J=2.3 Hz, 1H), 8.48-8.42 (m, 1H), 8.24-8.16 (m, 1H), 8.05-7.99 (m, 1H), 7.87 (d, J=8.5 Hz, 1H), 7.73 (d, J=1.7 Hz, 1H), 7.57-7.49 (m, 2H), 7.46 (t, J=8.1 Hz, 1H), 7.41-7.35 (m, 1H), 6.87 (t, J=72.7 Hz, 1H), 6.42 (d, J=7.2 Hz, 1H), 5.07 (t, J=6.6 Hz, 1H), 3.57-3.47 (m, 1H), 2.91 (d, J=13.3 Hz, 1H), 1.85 (s, 3H), 1.82 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.82 (1F), ?80.83 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 36.48.

Example 4: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-fluoropyridin-3-yl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0280] ##STR00191##

Preparation 4A: 5-bromo-2-(dimethylphosphoryl)-3-fluoropyridine

[0281] ##STR00192##

[0282] To a stirred solution of 2,5-dibromo-3-fluoropyridine (5.00 g, 19.617 mmol) and (methylphosphonoyl)methane (1.68 g, 21.579 mmol) in 1,4-dioxane (50 mL) were added Pd.sub.2(dba).sub.3 (898 mg, 0.981 mmol) and TEA (3.3 mL, 23.540 mmol) at room temperature. The resulting mixture was stirred for overnight at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1), to afford 5-bromo-2-(dimethylphosphoryl)-3-fluoropyridine (1.78 g, 36%) as a brown solid. MS ESI calculated for C.sub.7H.sub.8BrFNOP [M+H].sup.+ 251.95 253.95, found 251.95 253.95. .sup.1H NMR (300 MHz, Chloroform-d) ?8.65 (s, 1H), 7.76-7.69 (m, 1H), 1.90 (s, 3H), 1.87 (s, 3H).

Example 4: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-fluoropyridin-3-yl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0283] ##STR00193##

[0284] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 5-bromo-2-(dimethylphosphoryl)-3-fluoropyridine (26 mg, 0.104 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%), followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20% B to 40% B in 40 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)-5-fluoropyridin-3-yl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (16 mg, 29%) as a white solid. MS ESI calculated for C.sub.26H.sub.22F.sub.3N.sub.4O.sub.3P [M+H].sup.+ 527.14, found 527.20. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.81 (s, 1H), 8.54-8.44 (m, 1H), 7.88-7.78 (m, 1H), 7.77-7.71 (m, 1H), 7.70-7.60 (m, 1H), 7.51-7.37 (m, 2H), 7.36-7.26 (m, 1H), 6.90 (t, J=72.8 Hz, 1H), 6.37-6.26 (m, 1H), 5.07-4.95 (m, 1H), 3.53 (s, 3H), 3.54-3.45 (m, 1H), 2.97-2.85 (m, 1H), 1.96 (s, 3H), 1.90 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.81 (1F), ?80.83 (1F), ?117.00 (0F). .sup.31P NMR (122 MHz, Chloroform-d) ? 35.14 (1P).

Example 5: (1R,11R)-18-(difluoromethoxy)-12-methyl-5-[6-(1-oxo-1lambda5-phospholan-1-yl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0285] ##STR00194##

Preparation 5A: 1lambda5-phospholan-1-one

[0286] ##STR00195##

[0287] To a solution of 1,4-dibromobutane (19.62 g, 90.868 mmol) in THF (100 mL) was added activated magnesium powder (4.42 g, 181.736 mmol) in ports. The mixture was stirred at <30? C. for 2 h. To the above mixture was added dimethyl phosphite (5.00 g, 45.434 mmol) in 50 mL THF dropwise over 0.5 h at <30? C. The resulting mixture was stirred for additional 1 h at room temperature. The reaction was quenched by the addition of 20 g of K.sub.2CO.sub.3 in water (50 mL) at 20? C. The resulting mixture was filtered, and the filter cake was washed with EtOH (3?10 mL). The filtrate was concentrated under reduced pressure. This resulted in 1lambda5-phospholan-1-one (3.10 g, 51%) as a colorless oil. .sup.31P NMR (162 MHz, Chloroform-d) ? 47.62 (1P).

Preparation 5B: 1-(5-bromopyridin-2-yl)-1lambda 5-phospholan-1-one

[0288] ##STR00196##

[0289] A solution of Pd.sub.2(dba).sub.3 (320 mg, 0.352 mmol), DIPEA (0.55 g, 4.226 mmol) and XantPhos (410 mg, 0.704 mmol) in 1,4-dioxane (6 mL) was stirred for 15 min at room temperature under nitrogen atmosphere. To the above mixture were added 5-bromo-2-iodopyridine (1.00 g, 3.522 mmol) and 1lambda5-phospholan-1-one (1.47 g, 14.088 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional overnight at 80? C. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20:1) to afford 1-(5-bromopyridin-2-yl)-1lambda5-phospholan-1-one (218 mg, 23%) as a yellow solid. MS ESI calculated for C.sub.9H.sub.11BrNOP [M+H].sup.+, 259.98 261.98, found 259.90 261.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.78 (s, 1H), 8.09-8.02 (m, 1H), 8.02-7.95 (m, 1H), 2.25-1.87 (m, 8H).

Example 5: (1R,11R)-18-(difluoromethoxy)-12-methyl-5-[6-(1-oxo-1lambda5-phospholan-1-yl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0290] ##STR00197##

[0291] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 1-(5-bromopyridin-2-yl)-1lambda5-phospholan-1-one (27 mg, 0.104 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in H.sub.2O (0.5 mL) at room temperature. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20% B to 40% B in 40 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-12-methyl-5-[6-(1-oxo-1lambda5-phospholan-1-yl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (25 mg, 45%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.2N.sub.4O.sub.3P [M+H].sup.+ 535.16, found 535.15. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.95 (s, 1H), 8.50 (d, J=8.1 Hz, 1H), 8.25-8.20 (m, 1H), 8.03-7.98 (m, 1H), 7.86-7.71 (m, 2H), 7.52-7.27 (m, 3H), 7.11-6.62 (m, 1H), 6.32-6.29 (m, 1H), 5.02-4.99 (m, 1H), 3.56-3.46 (m, 4H), 2.94-2.88 (m, 1H), 2.24-1.95 (m, 8H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.73 (2F). .sup.31P NMR (122 MHz, Chloroform-d) ? 62.17 (1P).

Example 6: (1R,11R)-18-(difluoromethoxy)-12-methyl-5-[6-(4-oxo-1,4lambda5-oxaphosphinan-4-yl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0292] ##STR00198##

Preparation 6A. 4-hydroxy-1,4lambda5-oxaphosphinan-4-one

[0293] ##STR00199##

[0294] A mixture of ammonium hypophosphite (3.49 g, 43.119 mmol) and hexamethyldisilazane (13.92 g, 86.238 mmol) was stirred for 4 h at 120? C. under nitrogen atmosphere. To the above mixture was added 1-bromo-2-(2-bromoethoxy)ethane (10.00 g, 43.119 mmol) dropwise over 10 min at 120? C. The resulting mixture was stirred for additional 4 h at 120? C. The mixture was allowed to cool down to room temperature and added EtOH (20 mL). The resulting mixture was stirred for additional 1 h at 100? C. The resulting mixture was allowed to cool down to room temperature. The mixture was filtered, the filter cake was washed with dichloromethane (2?10 mL). The filtrate was concentrated under reduced pressure to afford the crude 4-hydroxy-1,4lambda5-oxaphosphinan-4-one (7.40 g, 25%) as a yellow liquid. The crude product was used in the next step directly without further purification.

Preparation 6B: 4-chloro-1,4lambda5-oxaphosphinan-4-one

[0295] ##STR00200##

[0296] To a stirred solution of 4-hydroxy-1,4lambda5-oxaphosphinan-4-one (5.80 g, 42.620 mmol) in DCM (60 mL) was added oxalyl chloride (9.20 g, 72.454 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for overnight at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was dissolved in toluene (50 mL). The mixture was concentrated under vacuum to afford the crude 4-chloro-1,4lambda5-oxaphosphinan-4-one (6.00 g, 91%) as a yellow liquid. The crude product was used in the next step directly without further purification.

Preparation 6C: 1,4lambda5-oxaphosphinan-4-one

[0297] ##STR00201##

[0298] To a stirred solution of 4-chloro-1,4lambda5-oxaphosphinan-4-one (5.60 g, 36.239 mmol) in DCM (60 mL) was added 1N DIBAL-H (36.24 mL, 36.239 mmol) dropwise at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 2 h at ?78? C. The reaction was quenched by the addition of CH.sub.3OH (6 mL) at ?78? C., then this reaction was stirred for 5 min at ?78? C. The mixture was allowed to warm up to 0? C. and was added 10% acetic acid in water (50 mL). The resulting mixture was extracted with DCM (5?100 mL). The combined organic layers were dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford the crude 1,4lambda5-oxaphosphinan-4-one (2.50 g, 57%) as a yellow oil. MS ESI calculated for C.sub.4H.sub.9O.sub.2P [M+H].sup.+ 121.03, found 121.25.

Preparation 6D: 4-(5-bromopyridin-2-yl)-1,4lambda5-oxaphosphinan-4-one

[0299] ##STR00202##

[0300] A solution of Pd.sub.2(dba).sub.3 (258 mg, 0.282 mmol) and XantPhos (326 mg, 0.564 mmol) in 1,4-dioxane (10 mL) was stirred for 10 min at room temperature under nitrogen atmosphere. To the above mixture were added a solution of 5-bromo-2-iodopyridine (800 mg, 2.818 mmol) and TEA (0.60 mL, 4.227 mmol) in 1,4-dioxane (10 mL) at room temperature. The resulting mixture was stirred for additional overnight at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20:1) to afford 4-(5-bromopyridin-2-yl)-1,4lambda5-oxaphosphinan-4-one (260 mg, 33%) as a white solid. MS ESI calculated for C.sub.9H.sub.11BrNO.sub.2P [M+H].sup.+ 275.97 277.97, found 275.95 277.95. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.82 (s, 1H), 8.04-7.99 (m, 2H), 4.25-4.15 (m, 4H), 2.51-2.36 (m, 2H), 2.13-1.99 (m, 2H).

Example 6: (1R,11R)-18-(difluoromethoxy)-12-methyl-5-[6-(4-oxo-1,4lambda5-oxaphosphinan-4-yl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0301] ##STR00203##

[0302] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 4-(5-bromopyridin-2-yl)-1,4lambda5-oxaphosphinan-4-one (29 mg, 0.104 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC (Column: C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20% B to 40% B in 40 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-12-methyl-5-[6-(4-oxo-1,4lambda5-oxaphosphinan-4-yl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (25 mg, 44%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.2N.sub.4O.sub.4P [M+H].sup.+ 551.16, found 551.05. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.99 (s, 1H), 8.58-8.41 (m, 1H), 8.20-8.15 (m, 1H), 8.06-8.01 (m, 1H), 7.86-7.66 (m, 2H), 7.60-7.40 (m, 2H), 7.37-7.21 (m, 1H), 6.86 (t, J=73.1 Hz, 1H), 6.32-6.29 (m, 1H), 5.02-4.96 (m, 1H), 4.28-4.18 (m, 4H), 3.54-3.44 (m, 4H), 2.94-2.85 (m, 1H), 2.61-2.51 (m, 2H), 2.13-2.02 (m, 2H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.71 (2F). .sup.31P NMR (122 MHz, Chloroform-d) ? 25.96 (1P).

Example 7: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0303] ##STR00204##

Preparation 7A: 5-bromo-2-[(dimethylphosphoryl)methoxy]pyridine

[0304] ##STR00205##

[0305] To a solution of 5-bromopyridin-2-ol (2.30 g, 13.219 mmol) and chloro(dimethylphosphoryl)methane (1.05 g, 8.276 mmol) in DMF (12 mL) was added K.sub.2CO.sub.3 (5.48 g, 39.657 mmol) at room temperature. The mixture was stirred for overnight at 100? C. The resulting mixture was allowed to cool down to room temperature and purified by reversed-phase flash chromatography to afford 5-bromo-2-[(dimethylphosphoryl)methoxy]pyridine (538 mg, 29%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.11BrNO.sub.2P [M+H].sup.+ 263.97 265.97, found 264.00 266.00. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.20 (d, J=2.5 Hz, 1H), 7.73-7.68 (m, 1H), 6.75 (d, J=8.7 Hz, 1H), 4.65 (d, J=5.9 Hz, 2H), 1.63 (s, 3H), 1.59 (s, 3H).

Example 7: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0306] ##STR00206##

[0307] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 5-bromo-2-[(dimethylphosphoryl)methoxy]pyridine (27 mg, 0.104 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20% B to 40% B in 40 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (20 mg, 36%) as a white solid. MS ESI calculated for C.sub.27H.sub.25F.sub.2N.sub.4O.sub.4P [M+H].sup.+ 539.16, found 539.20. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.54-8.45 (m, 1H), 8.40-8.33 (m, 1H), 7.93-7.71 (m, 2H), 7.67-7.60 (m, 1H), 7.49-7.35 (m, 2H), 7.36-7.23 (m, 1H), 6.94-6.88 (m, 1H), 6.85 (t, J=72.9 Hz, 1H), 6.34-6.19 (m, 1H), 4.97-4.94 (m, 1H), 4.78-4.71 (m, 2H), 3.61-3.33 (m, 4H), 2.93-2.84 (m, 1H), 1.66 (s, 3H), 1.61 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.68 (1F), ?80.71 (1F). .sup.31P NMR (122 MHz, Chloroform-d) ? 41.71 (1P).

Example 8: (1R,11R)-18-(difluoromethoxy)-5-[2-(dimethylphosphoryl)pyrimidin-5-yl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0308] ##STR00207##

[0309] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 5-bromo-2-(dimethylphosphoryl)pyrimidine (24 mg, 0.104 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-[2-(dimethylphosphoryl)pyrimidin-5-yl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (20 mg, 38%) as a white solid. MS ESI calculated for C.sub.25H.sub.22F.sub.2N.sub.5O.sub.3P [M+H].sup.+ 510.14, found 510.15. .sup.1H NMR (300 MHz, Chloroform-d) ? 9.14-9.04 (m, 2H), 8.55-8.44 (m, 1H), 7.92-7.82 (m, 1H), 7.78-7.71 (m, 1H), 7.53-7.36 (m, 2H), 7.35-7.25 (m, 1H), 6.87 (t, J=72.7 Hz, 1H), 6.38-6.27 (m, 1H), 5.06-4.96 (m, 1H), 3.63-3.42 (m, 4H), 2.98-2.86 (m, 1H), 1.98-1.85 (m, 6H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.68 (1F), ?80.76 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 34.60 (1P).

Example 9: (1R,11R)-18-(difluoromethoxy)-5-(2-[(dimethylphosphoryl)methoxy]pyrimidin-5-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0310] ##STR00208##

Preparation 9A: 5-bromo-2-[(dimethylphosphoryl)methoxy]pyrimidine

[0311] ##STR00209##

[0312] To a stirred solution of 5-bromo-2-chloropyrimidine (3.50 g, 18.094 mmol) and (dimethylphosphoryl)methanol (2.35 g, 21.713 mmol) in DMF (40 mL) was added K.sub.2CO.sub.3 (7.50 g, 54.282 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. The resulting mixture was diluted with water (250 mL) and extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layers were washed with brine (5?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 5-bromo-2-[(dimethylphosphoryl)methoxy]pyrimidine (3.90 g, 81%) as a white solid. MS ESI calculated for C.sub.7H.sub.10BrN.sub.2O.sub.2P [M+H].sup.+ 264.97 266.97, found 264.85 266.85. .sup.1H NMR (300 MHz, MeOD) ? 8.70 (s, 2H), 4.78 (d, J=5.5 Hz, 2H), 1.69 (s, 3H), 1.65 (s, 3H).

Example 9: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]pyrimidin-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0313] ##STR00210##

[0314] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 4-(5-bromopyridin-2-yl)-1,4lambda5-oxaphosphinan-4-one (29 mg, 0.104 mmol) in 1,4-dioxane (2 mL) was added solution of K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20% B to 40% B in 40 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]pyrimidin-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (25 mg, 45%) as a white solid. MS ESI calculated for C.sub.26H.sub.24F.sub.2N.sub.5O.sub.4P [M+H].sup.+ 540.15, found 540.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.75 (s, 2H), 8.53-847 (m, 1H), 7.85 (d, J=8.5, 1H), 7.68-7.65 (m, 1H), 7.48-7.40 (m, 2H), 7.35-7.31 (m, 1H), 6.88 (t, J=72.8 Hz, 1H), 6.32 (d, J=7.2 Hz, 1H), 5.10 (d, J=7.1 Hz, 1H), 4.81 (d, J=6.9 Hz, 2H), 3.52-3.48 (m, 4H), 2.92 (d, J=13.6 Hz, 1H), 1.74 (s, 3H), 1.70 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.73 (1F), ?80.90 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 43.56 (1P).

Example 10: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]-5-fluoropyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo [9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0315] ##STR00211##

Preparation 10A: 5-bromo-2-[(dimethyl phosphoryl) methoxy]-3-fluoropyridine

[0316] ##STR00212##

[0317] A mixture of (dimethyl phosphoryl) methanol (56 mg, 0.516 mmol) and NaH (21 mg, 0.516 mmol, 60%) in THF (2 mL) was stirred for 30 min at 0? C. To the above mixture was added 5-bromo-2,3-difluoropyridine (100 mg, 0.516 mmol) at room temperature. The resulting mixture was stirred for additional 3 h at room temperature. The reaction was quenched with water and purified by reversed-phase flash chromatography (C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm) to give in 5-bromo-2-[(dimethyl phosphoryl) methoxy]-3-fluoropyridine (120 mg, 82%) as a white solid. MS ESI calculated for C.sub.8H.sub.10BrFNO.sub.2P [M+H].sup.+, 281.96, found 281.9. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.02 (d, J=2.1 Hz, 1H), 7.57-7.52 (m, 1H), 4.70 (d, J=6.2 Hz, 2H), 1.66 (s, 3H), 1.63 (s, 3H).

Example 10: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]-5-fluoropyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo [9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0318] ##STR00213##

[0319] To a solution of 5-bromo-2-[(dimethyl phosphoryl) methoxy]-3-fluoropyridine (32 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo [9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography (DCM/MeOH, 0% to 10%), followed by Prep-HPLC (C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 40% gradient in 30 min; detector, 254 nm) to give (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]-5-fluoropyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo [9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (19 mg, 32%) as a white solid. MS ESI calculated for C.sub.27H.sub.24F.sub.3N.sub.4O.sub.4P [M+H].sup.+, 557.15, found 557.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 8.15 (d, J=2.1 Hz, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.66-7.56 (m, 2H), 7.43 (t, J=8.2 Hz, 1H), 7.41-7.36 (m, 1H), 7.35-7.29 (m, 1H), 6.86 (t, J=72.9 Hz, 1H), 6.29 (d, J=7.1 Hz, 1H), 4.99 (d, J=7.1 Hz, 1H), 4.79 (d, J=6.4 Hz, 2H), 3.53 (s, 3H), 3.52-3.42 (m, 1H), 2.90 (d, J=13.5 Hz, 1H), 1.69 (s, 3H), 1.66 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.76 (2F), ?139.34 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 42.01 (1P).

Example 11: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methoxy]pyridin-3-yl}-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0320] ##STR00214##

[0321] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.128 mmol) and 5-bromo-2-(dimethylphosphoryl)pyridine (25 mg, 0.107 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (82 mg, 0.384 mmol) in H.sub.2O (0.5 mL) at room temperature. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography (DCM/MeOH, 0% to 10%), followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-(6-[(dimethylphosphoryl)methoxy]pyridin-3-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (35 mg, 52%) as a white solid. MS ESI calculated for C.sub.26H.sub.23F.sub.2N.sub.4O.sub.4P [M+H].sup.+ 525.14, found 525.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47-8.40 (m, 1H), 8.39-8.29 (m, 1H), 7.87-7.65 (m, 3H), 7.64-7.53 (m, 1H), 7.50-7.29 (m, 3H), 7.08-6.65 (m, 2H), 6.37 (d, J=7.2 Hz, 1H), 4.99 (t, J=6.6 Hz, 1H), 4.75 (d, J=6.0 Hz, 2H), 3.55-3.40 (m, 1H), 2.88 (d, J=13.3 Hz, 1H), 1.66 (s, 3H), 1.63 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.79 (2F). .sup.31P NMR (162 MHz, Chloroform-d) ? 41.85 (1P).

Example 12: (1R,11R)-18-(difluoromethoxy)-5-(2-[(dimethylphosphoryl)methoxy]pyrimidin-5-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0322] ##STR00215##

[0323] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.128 mmol) and 5-bromo-2-[(dimethylphosphoryl)methoxy]pyrimidine (34 mg, 0.128 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (82 mg, 0.384 mmol) in H.sub.2O (0.5 mL) at room temperature. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography (DCM/MeOH, 0% to 10%) followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]pyrimidin-5-yl}-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (35 mg, 52%) as a white solid. MS ESI calculated for C.sub.25H.sub.22F.sub.2N.sub.5O.sub.4P [M+H].sup.+ 526.14, found 526.05. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 9.15 (d, J=6.9 Hz, 1H), 8.90 (s, 2H), 8.28-8.17 (m, 1H), 7.88-7.65 (m, 3H), 7.58-7.53 (m, 1H), 7.52-7.45 (m, 2H), 6.36 (d, J=7.1 Hz, 1H), 4.89 (t, J=6.8 Hz, 1H), 4.70 (d, J=5.2 Hz, 2H), 3.53-3.44 (m, 1H), 2.75 (d, J=13.3 Hz, 1H), 1.56 (s, 3H), 1.52 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.89 (1F), ?82.58 (1F). .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 37.61 (1P).

Example 13; (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)phenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0324] ##STR00216##

Preparation 13A: 1-bromo-4-(dimethylphosphoryl)benzene

[0325] ##STR00217##

[0326] To a stirred solution of 4-bromoiodobenzene (20.00 g, 70.695 mmol) and (methylphosphonoyl)methane (5.52 g, 70.695 mmol) in 1,4-dioxane (200 mL) were added Xantphos (4.09 g, 7.069 mmol), TEA (8.58 g, 84.834 mmol) and Pd.sub.2(dba).sub.3 (3.24 g, 3.535 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 4 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography (CH.sub.2Cl.sub.2/MeOH, 10:1) to afford 1-bromo-4-(dimethylphosphoryl)benzene (14.10 g, 85%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.10BrOP [M+H].sup.+, 232.97 234.97, found 233.00 235.00. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.69-7.48 (m, 4H), 1.74 (s, 3H), 1.70 (s, 3H).

Example 13: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)phenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0327] ##STR00218##

[0328] A mixture of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.125 mmol), 1-bromo-4-(dimethylphosphoryl)benzene (34 mg, 0.150 mmol), K.sub.1PO.sub.4 (79 mg, 0.375 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) in dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 2 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. and concentrated under vacuum. The residue was purified by silica gel column chromatography (DCM/MeOH, 0% to 10%) followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 60% B in 20 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)phenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (23 mg, 36%) as a white solid. MS ESI calculated for C.sub.27H.sub.24F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 508.15, found 508.25. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.56-8.48 (m, 1H), 7.91-7.70 (m, 6H), 7.59-7.53 (m, 1H), 7.46 (t, J=8.2 Hz, 1H), 7.37-7.30 (m, 1H), 6.87 (t, J=72.8 Hz, 1H), 6.34 (d, J=6.9 Hz, 1H), 5.08 (d, J=6.7 Hz, 1H), 3.57 (s, 3H), 3.56-3.43 (m, 1H), 2.93 (d, J=13.5 Hz, 1H), 1.83 (s, 3H), 1.79 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.70 (2F). .sup.31P NMR (121 MHz, Chloroform-d) ? 34.00 (1P).

Example 14: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0329] ##STR00219##

Preparation 14A: 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene

[0330] ##STR00220##

[0331] To a solution of 4-bromo-2-fluoro-1-iodobenzene (2.00 g, 6.647 mmol) and (methylphosphonoyl)methane (0.57 g, 7.312 mmol) in 1,4-dioxane (20 mL) were added TEA (0.81 g, 7.976 mmol), Xantphos (0.38 g, 0.665 mmol) and Pd.sub.2(dba).sub.3 (0.30 g, 0.332 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 70? C. under nitrogen atmosphere. The mixture was diluted with water (50 mL). The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layers were washed with brine (3?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (CH.sub.2Cl.sub.2/MeOH, 20:1) to afford 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (1.24 g, 74%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.9BrFOP [M+H].sup.+, 250.96 252.96, found 250.90 252.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.90-7.81 (m, 1H), 7.52-7.47 (m, 1H), 7.35-7.30 (m, 1H), 1.81 (d, J=1.2 Hz, 3H), 1.78 (d, J=1.2 Hz, 3H).

Example 14: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0332] ##STR00221##

[0333] A mixture of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.125 mmol), 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (37 mg, 0.150 mmol), K.sub.3PO.sub.4 (79 mg, 0.375 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 2 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature and concentrated under vacuum. The residue was purified by silica gel column chromatography (DCM/MeOH, 0% to 10%/), followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate. 60 mL/min; Gradient: 30% B to 55% B in 20 min; 254/220 nm) to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (17 mg, 26%) as a white solid. MS ESI calculated for C.sub.27H.sub.23F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 526.14, found 526.30. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.52 (d, J=8.2 Hz, 1H), 8.14-7.98 (m, 1H), 7.89-7.76 (m, 2H), 7.62-7.52 (m, 2H), 7.47 (t, J=8.2 Hz, 1H), 7.41-7.31 (m, 2H), 6.89 (t, J=72.9 Hz, 1H), 6.40-6.30 (m, 1H), 5.20-5.03 (m, 1H), 3.58 (s, 3H), 3.56-3.41 (m, 1H), 1.89 (s, 4H), 1.84 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.79 (2F), ?105.70 (1F). .sup.31P NMR (121 MHz, Chloroform-d) ? 30.54 (1P).

Example 15: (7R,14R)-1-(difluoromethoxy)-11-(6-((dimethylphosphoryl)methoxy)pyridin-3-yl)-6-(methyl-d.SUB.3.)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0334] ##STR00222##

Preparation 15A: (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0335] ##STR00223##

[0336] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (300 mg, 0.798 mmol) in dry THF (6 mL) was added 1N KHMDS (0.96 mL, 0.958 mmol) in THF dropwise at ?78? C. under nitrogen atmosphere. The resulting solution was stirred for 1 h at ?78? C. under nitrogen atmosphere. To the above solution was added iodomethane-d.sub.3 (231 mg, 1.596 mmol) dropwise over 2 min at ?78? C. The resulting mixture was allowed to warm slowly to room temperature, and stirred for 3 h at room temperature under nitrogen atmosphere. The resulting solution was quenched by the addition of sat. NH.sub.4Cl (aq.) (10 mL), and extracted with EtOAc (2?15 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (CH.sub.2Cl.sub.2/MeOH, 10:1) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d.sub.3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (290 mg, 92%) as a white solid. MS ESI calculated for C.sub.19H.sub.11D.sub.3ClF.sub.2N.sub.3O.sub.2 [M+H].sup.+ 393.09 395.09, found 393.05 395.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.49 (dd, J=8.2, 1.3 Hz, 1H), 7.62 (d, J=8.7 Hz, 1H), 7.46-7.41 (m, 2H), 7.35-7.32 (m, 1H), 7.21 (dd, J=8.7, 2.0 Hz, 1H), 7.02-6.65 (m, 1H), 6.21-6.19 (m, 1H), 4.95-4.93 (m, 1H), 3.47-3.40 (m, 1H), 2.88-2.84 (m, 1H).

Preparation 15B: (7R,14R)-1-(difluoromethoxy)-6-(methyl-d.SUB.3.)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0337] ##STR00224##

[0338] To a stirred mixture of (1R,11R)-5-chloro-18-(difluoromethoxy)-12-(2H3)methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (300 mg, 0.764 mmol), KOAc (225 mg, 2.292 mmol) and BPD (291 mg, 1.146 mmol) in 1,4-dioxane (5 mL) were added PCy.sub.3.Math.HBF.sub.4 (28 mg, 0.076 mmol) and Pd.sub.2(dba).sub.3 (70 mg, 0.076 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 140? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature and concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (7R,14R)-1-(difluoromethoxy)-6-(methyl-d.sub.3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[A]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (300 mg, 81%) as a yellow oil. MS ESI calculated for C.sub.25H.sub.23D.sub.3BF.sub.2N.sub.3O.sub.4 [M+H].sup.+ 485.22, found 485.20.

Example 15: (7R,14R)-1-(difluoromethoxy)-11-(6-((dimethylphosphoryl)methoxy)pyridin-3-yl)-6-(methyl-d.SUB.3.)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0339] ##STR00225##

[0340] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d.sub.3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 5-bromo-2-[(dimethylphosphoryl)methoxy]pyridine (27 mg, 0.103 mmol) in 1,4-dioxane (2 mL) was added a solution of K.sub.3PO.sub.4 (66 mg, 0.309 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional 2 h at 100? C. The mixture was allowed to cool down to room temperature and concentrated under vacuum. The residue was purified by silica gel column chromatography (DCM/MeOH, 0% to 10%) followed by Prep-HPLC (C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm) to afford (7R,14R)-1-(difluoromethoxy)-11-(6-((dimethylphosphoryl)methoxy)pyridin-3-yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (20 mg, 36%) as a white solid. MS ESI calculated for C.sub.27H.sub.22D.sub.3F.sub.2N.sub.4O.sub.4P [M+H].sup.+ 542.18, found 542.25. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.41 (d, J=2.5 Hz, 1H), 8.29-8.24 (m, 1H), 8.02-7.98 (m, 1H), 7.82-7.63 (m, 3H), 7.52-7.45 (m, 3H), 7.04-7.02 (m, 1H), 6.30-6.28 (m, 1H), 5.23-5.21 (m, 1H), 4.63 (d, J=5.2 Hz, 2H), 3.48-3.40 (m, 1H), 2.83-2.80 (m, 1H), 1.54 (s, 3H), 1.51 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?82.00 (1F), ?82.15 (1F). .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 39.72 (1P).

Example 16: (1R,11R)-18-(difluoromethoxy)-5-(6-{[(dimethylphosphoryl)methyl]amino}-5-fluoropyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0341] ##STR00226##

Preparation 16A: 5-bromo-N-[(dimethylphosphoryl)methyl]-3-fluoropyridin-2-amine

[0342] ##STR00227##

[0343] To a solution of 5-bromo-3-fluoropyridin-2-amine (500 mg, 2.618 mmol) in THF (10 mL) was added sodium hydride (120 mg, 3.011 mmol, 60% in oil) in ports at room temperature. The mixture was stirred for 30 min at room temperature. Then chloro(dimethylphosphoryl)methane (380 mg, 3.011 mmol) was added and the mixture was allowed to warm to 50? C. and stirred for 3 h. The reaction mixture was quenched by water and extracted with DCM (3?25 mL). The combined organic layers were concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in 5-bromo-N-[(dimethylphosphoryl)methyl]-3-fluoropyridin-2-amine (227 mg, 30%) as a white solid. MS ESI calculated for C.sub.8H.sub.11BrFN.sub.2OP [M+H].sup.+, 280.98, found 280.9. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.93 (d, J=1.9 Hz, 1H), 7.37-7.31 (m, 1H), 5.56 (s, 1H), 4.04-3.88 (m, 2H), 1.69 (s, 3H), 1.65 (s, 3H).

Example 16: (1R,11R)-18-(difluoromethoxy)-5-(6-{[(dimethylphosphoryl)methyl]amino}-5-fluoropyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0344] ##STR00228##

[0345] To a solution of 5-bromo-N-[(dimethylphosphoryl)methyl]-3-fluoropyridin-2-amine (32 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 80? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered, and the filter cake was washed with CH.sub.3OH (3?10 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-(6-([(dimethylphosphoryl)methyl]amino)-5-fluoropyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (30 mg, 52%) as a white solid. MS ESI calculated for C.sub.27H.sub.25F.sub.3N.sub.5O.sub.3P [M+H].sup.+, 556.16, found 556.10. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.53-8.45 (m, 1H), 8.16-8.09 (m, 1H), 7.79-7.71 (m, 1H), 7.61-7.56 (m, 1H), 7.49-7.29 (m, 4H), 6.85 (t, J=72.9 Hz, 1H), 6.27 (d, J=7.2 Hz, 1H), 5.36-5.26 (m, 1H), 4.97 (d, J=7.1 Hz, 1H), 4.03 (t, J=6.0 Hz, 2H), 3.52 (s, 3H), 3.51-3.41 (m, 1H), 2.88 (d, J=13.6 Hz, 1H), 1.61 (s, 3H), 1.57 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?80.68 (1F), ?80.73 (1F), ?140.77 (1F). .sup.31P NMR (122 MHz, Chloroform-d) ? 42.22 (1P).

Example 17: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)pyridin-3-yl)-6-(methyl-d.SUB.3.)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0346] ##STR00229##

[0347] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d.sub.3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 5-bromo-2-(dimethylphosphoryl)pyridine (24 mg, 0.103 mmol) in 1,4-dioxane (2 mL) was added solution of K.sub.3PO.sub.4 (66 mg, 0.309 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)pyridin-3-yl)-6-(methyl-d.sub.3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (20 mg, 38%) as a white solid. MS ESI calculated for C.sub.26H.sub.20D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+ 512.17, found 512.20. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 9.03 (s, 1H), 8.30-8.24 (m, 1H), 8.21-8.16 (m, 1H), 8.05-8.01 (m, 1H), 7.86-7.67 (m, 3H), 7.62-7.60 (m, 1H), 7.51-7.49 (m, 2H), 6.33-6.30 (m, 1H), 5.27-5.24 (m, 1H), 3.58-3.50 (m, 1H), 2.87-2.82 (m, 1H), 1.73 (s, 3H), 1.69 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.82 (1F), ?82.28 (1F). .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 34.01 (1P).

Example 18. (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]-3-fluorophenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0348] ##STR00230##

Preparation 18A: 4-bromo-1-[(dimethylphosphoryl)methoxy]-2-fluorobenzene

[0349] ##STR00231##

[0350] A solution of 4-bromo-2-fluorophenol (200 mg, 1.047 mmol) in CH.sub.3CN (4 mL) were treated with K.sub.2CO.sub.3 (434 mg, 3.141 mmol) and NaI (16 mg, 0.105 mmol) for 10 min at room temperature followed by the addition of chloro(dimethylphosphoryl)methane (265 mg, 2.094 mmol) dropwise at room temperature. The resulting mixture was stirred for 48 h at 80? C. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 4-bromo-1-[(dimethylphosphoryl)methoxy]-2-fluorobenzene (252 mg, 85%) as an off-white solid. MS ESI calculated for C.sub.9H.sub.11BrFO.sub.2P [M+H].sup.+, 280.97, found 280.80. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.33-7.28 (m, 1H), 7.27-7.22 (m, 1H), 6.98-6.90 (m, 1H), 4.29 (d, J=8.1 Hz, 2H), 1.72 (s, 3H), 1.68 (s, 3H).

Example 18: (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]-3-fluorophenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0351] ##STR00232##

[0352] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (80 mg, 0.166 mmol) and 4-bromo-1-[(dimethylphosphoryl)methoxy]-2-fluorobenzene (70 mg, 0.249 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (57 mg, 0.415 mmol) and Pd(dppf)Cl.sub.2CH.sub.2Cl.sub.2 (14 mg, 0.017 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]-3-fluorophenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (48 mg, 52%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.3N.sub.3O.sub.4P [M+H].sup.+, 556.15, found 556.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.48 (m, 1H), 7.78 (d, J=8.5 Hz, 1H), 7.66 (d, J=1.7 Hz, 1H), 7.49-7.40 (m, 2H), 7.38-7.29 (m, 3H), 7.16-7.08 (m, 1H), 6.86 (t, J=72.9 Hz, 1H), 6.31 (d, J=6.9 Hz, 1H), 5.08 (d, J=6.8 Hz, 1H), 4.36 (d, J=8.2 Hz, 2H), 3.55 (s, 3H), 3.53-3.43 (m, 1H), 2.91 (d, J=13.4 Hz, 1H), 1.73 (s, 3H), 1.70 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.75 (2F), ?133.46 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 42.79 (1P).

Example 19: (1R,11R)-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0353] ##STR00233##

Preparation 19 A: (1R,11R)-5-chloro-18-(difluoromethoxy)-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0354] ##STR00234##

[0355] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (100 mg, 0.266 mmol) in THF (3 mL) was added KHMDS (0.3 mL, 0.319 mmol, 1 M in THF) dropwise at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 0.5 h at ?78? C. under nitrogen atmosphere. To the above mixture was added ethyl iodide (62 mg, 0.399 mmol) dropwise at ?78? C. The resulting mixture was stirred for additional overnight at room temperature. The reaction was quenched with 1 mL sat. NH.sub.4Cl (aq.) at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20/1) to afford (1R,11R)-5-chloro-18-(difluoromethoxy)-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (75 mg, 64%) as a white solid. MS ESI calculated for C.sub.20H.sub.16ClF.sub.2N.sub.3O.sub.2 [M+H].sup.+, 404.09, found 403.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52 (d, J=8.3 Hz, 1H), 7.63 (d, J=8.7 Hz, 1H), 7.49 (d, J=2.0 Hz, 1H), 7.43 (t, J=8.2 Hz, 1H), 7.37-7.31 (m, 1H), 7.24-7.20 (m, 1H), 6.83 (t, J=73.1 Hz, 1H), 6.22 (d, J=7.1 Hz, 1H), 5.02 (d, J=7.1 Hz, 1H), 4.13-4.05 (m, 1H), 3.90-3.80 (m, 1H), 3.53-3.42 (m, 1H), 2.82 (d, J=13.5 Hz, 1H), 1.44 (t, J=7.1 Hz, 3H).

Preparation 19B: (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0356] ##STR00235##

To a stirred mixture of (1R,11R)-5-chloro-18-(difluoromethoxy)-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (75 mg, 0.186 mmol), potassium acetate (54 mg, 0.558 mmol) and BPD (70.75 mg, 0.279 mmol) in 1,4-dioxane (1 mL) were added Pd.sub.2(dba).sub.3 (17 mg, 0.019 mmol) and PCy.sub.3.Math.HBF.sub.4 (7 mg, 0.019 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 140? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (100 mg, 86%) as a yellow oil. MS ESI calculated for C.sub.26H.sub.28BF.sub.2N.sub.3O.sub.4 [M+H].sup.+ 496.21, found 496.05.

Example 19: (1R,11R)-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0357] ##STR00236##

[0358] To a solution of (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (100 mg, 0.202 mmol) and 5-bromo-2-(dimethylphosphoryl)pyridine (47 mg, 0.202 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added K.sub.3PO.sub.4 (128 mg, 0.606 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (16 mg, 0.020 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (0.1% FA), 15% to 40% gradient in 25 min; detector, 254 nm to afford (1R,11R)-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 47%) as a white solid. MS ESI calculated for C.sub.27H.sub.25F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 523.16, found 523.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.98-8.93 (m, 1H), 8.53 (d, J=8.3 Hz, 1H), 8.23-8.16 (m, 1H), 8.05-7.99 (m, 1H), 7.84 (d, J=8.4 Hz, 1H), 7.77 (d, J=1.9 Hz, 1H), 7.55-7.48 (m, 1H), 7.43 (t, J=8.2 Hz, 1H), 7.39-7.27 (m, 1H), 6.85 (t, J=72.9 Hz, 1H), 6.32 (d, J=7.0 Hz, 1H), 5.05 (d, J=7.1 Hz, 1H), 4.16-4.03 (m, 1H), 3.92-3.81 (m, 1H), 3.56-3.46 (m, 1H), 2.86 (d, J=13.4 Hz, 1H), 1.84 (s, 3H), 1.81 (s, 3H), 1.47 (t, J=7.1 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.76 (1F), ?80.77 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 36.52.

Example 20: (1R,11R)-18-(difluoromethoxy)-5-(6-[(dimethylphosphoryl)amino]pyridin-3-yl-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0359] ##STR00237##

Preparation 20A: 5-bromo-N-(dimethylphosphoryl)pyridin-2-amine

[0360] ##STR00238##

[0361] A mixture of dimethyphosphinoyl chloride (430 mg, 3.823 mmol) and 5-bromopyridin-2-amine (860 mg, 4.970 mmol) and TEA (774 mg, 7.646 mmol) in 1,4-dioxane (10 mL) was stirred for overnight at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) to afford 5-bromo-N-(dimethylphosphoryl)pyridin-2-amine (220 mg, 23%) as a white solid. MS ESI calculated for C.sub.7H.sub.10BrN.sub.2OP [M+H].sup.+, 248.97, found 248.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.20 (s, 1H), 7.62-7.56 (m, 1H), 6.82-6.74 (m, 1H), 1.83 (s, 3H), 1.80 (s, 3H).

Example 20: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)amino]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0362] ##STR00239##

[0363] To a solution of 5-bromo-N-(dimethylphosphoryl)pyridin-2-amine (28 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)amino]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 92%) as a white solid. MS ESI calculated for C.sub.26H.sub.24F.sub.2N.sub.5O.sub.3P [M+H].sup.+, 524.16, found 524.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.49 (d, J=8.2 Hz, 1H), 8.40 (d, J=2.5 Hz, 1H), 7.80-7.71 (m, 2H), 7.60 (s, 1H), 7.46-7.36 (m, 2H), 7.30 (d, J=8.1 Hz, 1H), 6.86 (d, J=73.0 Hz, 1H), 6.85-6.82 (m, 1H), 6.27 (d, J=7.2 Hz, 1H), 5.78 (s, 1H), 4.97 (d, J=7.1 Hz, 1H), 3.52 (s, 3H), 3.51-3.40 (m, 1H), 2.88 (d, J=13.6 Hz, 1H), 1.89 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.62 (1F), ?80.71 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 41.80 (1P).

Example 21: (1R,11R)-18-(difluoromethoxy)-5-{1-[(dimethylphosphoryl)methyl]pyrazol-4-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0364] ##STR00240##

Preparation 21A: 4-bromo-1-[(dimethylphosphoryl)methyl]pyrazole

[0365] ##STR00241##

[0366] To a solution of 4-bromopyrazole (100 mg, 0.680 mmol) in THF (2 mL) was added sodium hydride (30 mg, 0.748 mmol, 60% in oil) at 0? C. The mixture was stirred for 30 min. Then to above solution was added chloro(dimethylphosphoryl)methane (86 mg, 0.680 mmol). The mixture was stirred for 4 h at room temperature. The reaction mixture was quenched by water and extracted with DCM (3?10 mL). The combined organic layers were concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in 4-bromo-1-[(dimethylphosphoryl)methyl]pyrazole (100 mg, 62%) as a white solid. MS ESI calculated for C.sub.6H.sub.10BrN.sub.2OP [M+H].sup.+, 236.97 238.97, found 236.90 238.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.59 (s, 1H), 7.50 (s, 1H), 4.53 (d, J=7.4 Hz, 2H), 1.56 (s, 3H), 1.53 (s, 3H).

Example 21: (1R,11R)-18-(difluoromethoxy)-5-(1-[(dimethylphosphoryl)methyl]pyrazol-4-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0367] ##STR00242##

[0368] To a solution of 4-bromo-1-[(dimethylphosphoryl)methyl]pyrazole (27 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{1-[(dimethylphosphoryl)methyl]pyrazol-4-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (38 mg, 72%) as a white solid. MS ESI calculated for C.sub.25H.sub.24F.sub.2N.sub.5O.sub.3P [M+H].sup.+, 512.16, found 512.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51 (d, J=8.2 Hz, 1H), 7.83 (s, 2H), 7.78 (d, J=8.5 Hz, 1H), 7.68 (s, 1H), 7.52-7.43 (m, 2H), 7.33 (d, J=8.2 Hz, 1H), 6.94 (t, J=72.8 Hz, 1H), 6.36 (d, J=6.3 Hz, 1H), 5.26 (s, 1H), 4.61 (d, J=7.3 Hz, 2H), 3.62 (s, 3H), 3.59-3.48 (m, 1H), 2.95 (d, J=13.3 Hz, 1H), 1.61 (d, J=3.9 Hz, 3H), 1.57 (d, J=3.9 Hz, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.78 (1F), ?80.97 (1F). .sup.31P NMR (162 MHz, Chloroform-d) ? 540.53.

Example 22: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methyl]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

Preparation 22A: 5-bromo-2-(chloromethyl)pyridine

[0369] ##STR00243##

[0370] To a stirred solution of (5-bromopyridin-2-yl)methanol (5.00 g, 26.592 mmol) in DCM (50 mL) was added thionyl chloride (4.75 g, 39.888 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The reaction was quenched by the addition of sat. sodium bicarbonate (50 mL) at 0? C. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layers were washed with brine (2?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. This resulted in 5-bromo-2-(chloromethyl)pyridine (4.50 g, 81%) as a brown oil. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.66-8.60 (m, 1H), 7.88-7.80 (m, 1H), 7.42-7.36 (m, 1H), 4.63 (s, 2H).

Preparation 22B: 5-bromo-2-[(dimethylphosphoryl)methyl]pyridine

[0371] ##STR00244##

[0372] A solution of (methylphosphonoyl)methane (756 mg, 9.687 mmol) in THF (5 mL) was treated with NaHMDS (4.9 mL, 9.687 mmol, 2 N in THF) for 0.5 h at 0? C. under nitrogen atmosphere followed by the addition of 5-bromo-2-(chloromethyl)pyridine (2.00 g, 9.687 mmol) in THF (20 mL) dropwise at 0? C. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The reaction was quenched by the addition of water (50 mL) at room temperature. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?50 mL). The combined organic layers were washed with brine (3?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 5-bromo-2-[(dimethylphosphoryl)methyl]pyridine (270 mg, 11%) as a brown yellow oil. MS ESI calculated for C.sub.8H.sub.11BrNOP [M+H].sup.+, 247.98 249.98, found 247.90 249.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.60 (d, J=2.5 Hz, 1H), 7.83-7.78 (m, 1H), 7.31-7.27 (m, 1H), 3.35 (d, J=14.9 Hz, 2H), 1.54 (s, 3H), 1.51 (s, 3H).

Example 22: (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methyl]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0373] ##STR00245##

[0374] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (51 mg, 0.107 mmol) and 5-bromo-2-[(dimethylphosphoryl)methyl]pyridine (22 mg, 0.089 mmol) in 1,4-dioxane (2 mL) were added K.sub.3PO.sub.4 (56 mg, 0.267 mmol) in H.sub.2O (0.5 mL) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (7 mg, 0.009 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 20 B to 50 B in 30 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{6-[(dimethylphosphoryl)methyl]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (29 mg, 63%) as a white solid. MS ESI calculated for C.sub.27H.sub.25F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 523.16, found 523.20. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.77 (d, J=2.4 Hz, 1H), 8.30-8.23 (m, 1H), 8.00-7.94 (m, 1H), 7.87-7.66 (m, 3H), 7.58-7.53 (m, 1H), 7.52-7.46 (m, 2H), 7.45-7.40 (m, 1H), 6.30 (d, J=7.1 Hz, 1H), 5.25 (d, J=7.1 Hz, 1H), 3.57-3.47 (m, 1H), 3.39 (d, J=15.3 Hz, 2H), 3.36 (s, 3H), 2.83 (d, J=13.8 Hz, 1H), 1.45 (s, 3H), 1.42 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.53, ?81.98, ?82.38, ?82.83. .sup.31P NMR (162 MHz, DMSO) ? 38.92.

Example 23: (1R,11R)-18-(difluoromethoxy)-5-(6-([(dimethylphosphoryl)methyl]amino)pyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0375] ##STR00246##

Preparation 23A: 5-bromo-N-[(dimethylphosphoryl)methyl]pyridin-2-amine

[0376] ##STR00247##

[0377] To a solution of 5-bromopyridin-2-amine (250 mg, 1.445 mmol) in THF (5 mL) was added sodium hydride (60% in oil, 64 mg) at 0 degrees C. The mixture was stirred for 30 min. chloro(dimethylphosphoryl)methane (183 mg, 1.445 mmol) was added and the mixture was allowed to warm to room temperature and stirred for 3 h. The reaction mixture was quenched by water and extracted with DCM (3?25 mL). The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in 5-bromo-N-[(dimethylphosphoryl)methyl]pyridin-2-amine (50 mg, 13%) as a white solid. MS ESI calculated for C.sub.8H.sub.12BrN.sub.2OP [M+H].sup.+, 262.99 264.99, found 263.00 265.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.08 (d, J=2.4 Hz, 1H), 7.53-7.45 (m, 1H), 6.52 (d, J=8.9 Hz, 1H), 5.57 (s, 1H), 3.88 (s, 2H), 1.57 (s, 3H), 1.54 (s, 3H).

Example 23: (1R,11R)-18-(difluoromethoxy)-5-(6-([(dimethylphosphoryl)methyl]amino)pyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0378] ##STR00248##

[0379] To a solution of 5-bromo-N-[(dimethylphosphoryl)methyl]pyridin-2-amine (30 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered; the filter cake was washed with MeOH (3?5 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-(6-{[(dimethylphosphoryl)methyl]amino}pyridin-3-yl)-12-methyl-2,9,12-tri azapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (22 mg, 39%) as a white solid. MS ESI calculated for C.sub.27H.sub.26F.sub.2N.sub.5O.sub.3P [M+H].sup.+, 538.17, found 538.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.46 (m, 1H), 8.29 (d, J=2.4 Hz, 1H), 7.75 (d, J=8.5 Hz, 1H), 7.72-7.67 (m, 1H), 7.57 (d, J=1.6 Hz, 1H), 7.46-7.34 (m, 2H), 7.30 (d, J=8.1 Hz, 1H), 7.05-6.61 (m, 2H), 6.25 (d, J=7.2 Hz, 1H), 5.49 (s, 1H), 4.96 (d, J=7.1 Hz, 1H), 3.95 (t, J=5.7 Hz, 2H), 3.52 (s, 3H), 3.51-3.42 (m, 1H), 2.87 (d, J=13.5 Hz, 1H), 1.61 (s, 3H), 1.58 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.09, ?80.54, ?80.71, ?81.15. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.08.

Example 24: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0380] ##STR00249##

[0381] Into a 8 mL vial were added (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol), 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (36 mg, 0.145 mmol), K.sub.3PO.sub.4 (92 mg, 0.435 mmol), Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.014 mmol), 1,4-dioxane (2 mL) and water (0.6 mL) at room temperature. The resulting mixture was stirred for overnight at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 35% to 60% gradient in 20 min; detector, 254 nm. to afford (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (28 mg, 35%) as a white solid. MS ESI calculated for C.sub.27H.sub.20D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 529.16, found 529.30. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 8.07-7.98 (m, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.74 (d, J=1.8 Hz, 1H), 7.59-7.54 (m, 1H), 7.52-7.46 (m, 1H), 7.43 (t, J=8.2 Hz, 1H), 7.39-7.28 (m, 2H), 6.87 (t, J=72.9 Hz, 1H), 6.30 (d, J=7.2 Hz, 1H), 4.98 (d, J=7.1 Hz, 1H), 3.54-3.43 (m, 1H), 2.90 (d, J=13.6 Hz, 1H), 1.86 (s, 3H), 1.82 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.77, ?105.83, ?105.84. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.76.

Example 25: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]-1,3-thiazol-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0382] ##STR00250##

Preparation 25A: 5-bromo-2-[(dimethylphosphoryl)methoxy]-1,3-thiazole

[0383] ##STR00251##

[0384] To a stirred solution of 5-bromo-2-chloro-1,3-thiazole (500 mg, 2.519 mmol) in DMF (5 mL) was added NaH (111 mg, 2.771 mmol, 60%) at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at room temperature under nitrogen atmosphere. To the above mixture was added (dimethylphosphoryl)methanol (272 mg, 2.519 mmol) at 0? C. The resulting mixture was stirred for additional overnight at room temperature. The resulting mixture was diluted with EtOAc (100 mL). The resulting mixture was washed with 3?30 mL of water. The organic layers were concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 5-bromo-2-[(dimethylphosphoryl)methoxy]-1,3-thiazole (135 mg, 20%) as a yellow solid. MS ESI calculated for C.sub.6H.sub.9BrNO.sub.2PS [M+H].sup.+, 269.93 271.93, found 269.95 271.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.07 (s, 1H), 4.74 (d, J=5.8 Hz, 2H), 1.65 (s, 3H), 1.62 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 40.02.

Example 25: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]-1,3-thiazol-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0385] ##STR00252##

[0386] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 5-bromo-2-[(dimethylphosphoryl)methoxy]-1,3-thiazole (42 mg, 0.156 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) and K.sub.2CO.sub.3 (36 mg, 0.260 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]-1,3-thiazol-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (37 mg, 65%) as a white solid. MS ESI calculated for C.sub.25H.sub.23F.sub.2N.sub.4O.sub.4PS [M+H].sup.+, 545.11, found 545.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 7.70 (d, J=8.5 Hz, 1H), 7.56 (d, J=1.7 Hz, 1H), 7.43 (t, J=8.3 Hz, 1H), 7.38-7.27 (m, 3H), 6.87 (t, J=72.9 Hz, 1H), 6.26 (d, J=7.2 Hz, 1H), 4.97 (d, J=7.1 Hz, 1H), 4.79 (d, J=6.0 Hz, 2H), 3.52 (s, 3H), 3.50-3.41 (m, 1H), 2.88 (d, J=13.6 Hz, 1H), 1.68 (s, 3H), 1.65 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.54. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.06.

Example 26: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)amino]pyrimidin-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0387] ##STR00253##

Preparation 26A: 5-bromo-N-(dimethylphosphoryl)pyrimidin-2-amine

[0388] ##STR00254##

[0389] A solution of 5-bromopyrimidin-2-amine (619 mg, 3.556 mmol) in DMF (7 mL) was treated with NaH (142 mg, 3.556 mmol, 60%) for 30 min at 50? C. under nitrogen atmosphere followed by the addition of dimethylphosphinoyl chloride (100 mg, 0.889 mmol) at 0? C. The resulting mixture was stirred for 2 h at room temperature under nitrogen atmosphere. The reaction was quenched with water at room temperature. The aqueous layer was extracted with EtOAc (3?100 mL). The aqueous layer was concentrated under reduced pressure, to afford 5-bromo-N-(dimethylphosphoryl)pyrimidin-2-amine (80 mg, 9%) as a yellow solid. MS ESI calculated for C.sub.6H.sub.9BrN.sub.3OP [M+H].sup.+, 249.97 251.97, found 250.10, 252.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (s, 2H), 1.86 (s, 3H), 1.82 (s, 3H).

Example 26: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)amino]pyrimidin-5-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0390] ##STR00255##

[0391] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 5-bromo-N-(dimethylphosphoryl)pyrimidin-2-amine (26 mg, 0.104 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)amino]pyrimidin-5-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (10 mg, 18%) as a white solid. MS ESI calculated for C.sub.25H.sub.23F.sub.2N.sub.6O.sub.3P [M+H].sup.+, 525.15, found 525.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.71 (s, 2H), 8.51-8.47 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.63 (d, J=1.7 Hz, 1H), 7.47-7.36 (m, 2H), 7.35-7.31 (m, 1H), 7.21-6.80 (m, 1H), 6.30 (d, J=7.2 Hz, 1H), 4.99 (d, J=7.1 Hz, 1H), 3.53 (s, 3H), 3.52-3.43 (m, 1H), 2.90 (d, J=13.5 Hz, 1H), 1.93 (d, J=3.2 Hz, 3H), 1.89 (d, J=3.2 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.44, ?80.88, ?81.30, ?81.75. .sup.31P NMR (162 MHz, Chloroform-d) 41.11.

Example 27: (1R,11R)-5-[2-chloro-4-(dimethylphosphoryl)phenyl]-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0392] ##STR00256##

Preparation 27A: 1-bromo-2-chloro-4-(dimethylphosphoryl)benzene

[0393] ##STR00257##

[0394] A mixture of 1-bromo-2-chloro-4-iodobenzene (1.00 g, 3.151 mmol), (methylphosphonoyl)methane (270 mg, 3.466 mmol), Pd.sub.2(dba).sub.3 (144 mg, 0.158 mmol), XantPhos (182 mg, 0.315 mmol) and TEA (383 mg, 3.781 mmol) in 1,4-dioxane (10 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 1-bromo-2-chloro-4-(dimethylphosphoryl)benzene (800 mg, 95%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.9BrClOP [M+H].sup.+, 266.93 268.92, found 267.00 269.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.92-7.71 (m, 2H), 7.52-7.41 (m, 1H), 1.76 (s, 3H), 1.73 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 33.00.

Example 27. (1R,11R)-5-[2-chloro-4-(dimethylphosphoryl)phenyl]-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0395] ##STR00258##

[0396] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 1-bromo-2-chloro-4-(dimethylphosphoryl)benzene (42 mg, 0.156 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.260 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-5-[2-chloro-4-(dimethylphosphoryl)phenyl]-18-(difluoromethoxy)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (37 mg, 65%) as a white solid. MS ESI calculated for C.sub.27H.sub.23ClF.sub.2N.sub.3O.sub.3P [M+H].sup.+, 542.11, found 542.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.48 (m, 1H), 7.88-7.76 (m, 2H), 7.72-7.63 (m, 1H), 7.63-7.59 (m, 1H), 7.50-7.46 (m, 1H), 7.42 (t, J=8.2 Hz, 1H), 7.36-7.27 (m, 2H), 6.78 (d, J=72.3 Hz, 1H), 6.28 (d, J=7.2 Hz, 1H), 5.01 (d, J=7.1 Hz, 1H), 3.54 (s, 3H), 3.51-3.42 (m, 1H), 2.90 (d, J=13.6 Hz, 1H), 1.82 (s, 3H), 1.78 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.04, ?80.48, ?80.93, ?81.37. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.04.

Example 28: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0397] ##STR00259##

Preparation 28A: 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene

[0398] ##STR00260##

[0399] A mixture of 1-bromo-2-fluoro-4-iodobenzene (1.00 g, 3.323 mmol), (methylphosphonoyl)methane (285 mg, 3.655 mmol), Pd.sub.2(dba).sub.3 (152 mg, 0.166 mmol), XantPhos (192 mg, 0.332 mmol) and TEA (404 mg, 3.988 mmol) in 1,4-dioxane (10 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene (820 mg, 98%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.9BrFOP [M+H].sup.+, 250.96 252.98, found 251.00 253.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.73-7.69 (m, 1H), 7.53-7.47 (m, 1H), 7.41-7.34 (m, 1H), 1.77 (s, 3H), 1.73 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 33.08.

Example 28: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0400] ##STR00261##

[0401] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene (39 mg, 0.156 mmol) in 1.4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.260 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (20 mg, 36%) as a white solid. MS ESI calculated for C.sub.27H.sub.23F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 526.14, found 526.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.49 (d, J=8.1 Hz, 1H), 7.85-7.78 (m, 1H), 7.75 (s, 1H), 7.62-7.51 (m, 3H), 7.47-7.40 (m, 2H), 7.34-7.29 (m, 1H), 6.81 (t, J=72.8 Hz, 1H), 6.31 (d, J=7.1 Hz, 1H), 5.04 (s, 1H), 3.54 (s, 3H), 3.53-3.44 (m, 1H), 2.90 (d, J=13.5 Hz, 1H), 1.82 (s, 3H), 1.78 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.94, ?80.39, ?81.12, ?81.57, ?116.60. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.07.

Example 29: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-methylphenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0402] ##STR00262##

Preparation 29A: 1-bromo-4-(dimethylphosphoryl)-2-methylbenzene

[0403] ##STR00263##

[0404] A solution of 1-bromo-4-iodo-2-methylbenzene (1.00 g, 3.368 mmol), (methylphosphonoyl)methane (289 mg, 3.705 mmol), Pd.sub.2(dba).sub.3 (154 mg, 0.168 mmol), XantPhos (195 mg, 0.337 mmol) and TEA (409 mg, 4.042 mmol) in 1,4-dioxane (10 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) to afford 1-bromo-4-(dimethylphosphoryl)-2-methylbenzene (453 mg, 54%) as a yellow solid. MS ESI calculated for C.sub.9H.sub.12BrOP [M+H].sup.+, 246.98 248.98, found 247.05 249.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.71-7.57 (m, 2H), 7.38-7.31 (m, 1H), 1.74 (s, 3H), 1.71 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 33.90.

Example 29: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-methylphenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0405] ##STR00264##

[0406] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-methylbenzene (39 mg, 0.156 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-methylphenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (12 mg, 21%) as a white solid. MS ESI calculated for C.sub.28H.sub.26F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 522.17, found 522.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.47 (m, 1H), 7.77 (d, J=8.4 Hz, 1H), 7.73-7.65 (m, 1H), 7.60-7.51 (m, 1H), 7.47-7.38 (m, 2H), 7.38-7.27 (m, 2H), 7.24-7.17 (m, 1H), 6.75 (t, J=72.8 Hz, 1H), 6.25 (d, J=7.1 Hz, 1H), 5.00 (d, J=7.0 Hz, 1H), 3.54 (s, 3H), 3.52-3.43 (m, 1H), 2.89 (d, J=13.6 Hz, 1H), 2.30 (s, 3H), 1.80 (s, 3H), 1.77 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.16, ?80.61, ?80.73, ?81.17. .sup.31P NMR (162 MHz, Chloroform-d) ? 34.08.

Example 30: (1R,11R)-18-(difluoromethoxy)-5-(6-{[(dimethylphosphoryl)methyl](methyl)amino}pyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0407] ##STR00265##

Preparation 30A: 5-bromo-N-[(dimethylphosphoryl)methyl]-N-methylpyridin-2-amine

[0408] ##STR00266##

[0409] To a solution of 5-bromopyridin-2-amine (250 mg, 1.445 mmol) in THF (5 mL) was added sodium hydride (60% in oil, 64 mg) at 0 degrees C. The mixture was stirred for 30 min. chloro(dimethylphosphoryl)methane (183 mg, 1.445 mmol) was added and the mixture was allowed to warm to room temperature and stirred for 3 h. The reaction mixture was quenched by water and extracted with DCM (3?25 mL). The combined organic layers were concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in 5-bromo-N-[(dimethylphosphoryl)methyl]-N-methylpyridin-2-amine (50 mg, 12%) as a white solid. MS ESI calculated for C.sub.9H.sub.14BrN.sub.2OP [M+H].sup.+, 277.00, found 277.01. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.13-8.09 (m, 1H), 7.58-7.52 (m, 1H), 6.53-6.47 (m, 1H), 4.13 (d, J=4.7 Hz, 2H), 3.19 (s, 3H), 1.51 (s, 3H), 1.48 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 43.67.

Example 30: (1R,11R)-18-(difluoromethoxy)-5-(6-{[(dimethylphosphoryl)methyl](methyl)amino)pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0410] ##STR00267##

[0411] To a solution of 5-bromo-N-[(dimethylphosphoryl)methyl]-N-methylpyridin-2-amine (32 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered, and the filter cake was washed with MeOH (3?5 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-(6-{[(dimethylphosphoryl)methyl](methyl)amino}pyridin-3-yl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (21 mg, 36%) as a white solid. MS ESI calculated for C.sub.28H.sub.28F.sub.2N.sub.5O.sub.3P [M+H].sup.+, 552.19, found 552.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.46 (m, 1H), 8.36 (d, J=2.4 Hz, 1H), 7.80-7.72 (m, 2H), 7.60 (d, J=1.7 Hz, 1H), 7.46-7.36 (m, 2H), 7.33-7.28 (m, 1H), 7.07-6.62 (m, 2H), 6.27 (d, J=7.1 Hz, 1H), 4.96 (d, J=7.0 Hz, 1H), 4.26 (s, 2H), 3.52 (s, 3H), 3.51-3.41 (m, 1H), 3.28 (s, 3H), 2.88 (d, J=13.5 Hz, 1H), 1.57 (s, 3H), 1.54 (s, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.11, ?80.56, ?80.74, ?81.19. .sup.31P NMR (162 MHz, Chloroform-d) ? 43.95.

Example 31: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0412] ##STR00268##

[0413] To a solution of 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene (30 mg, 0.118 mmol) and (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.107 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (68 mg, 0.321 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol). After stirring for 1 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered, and the filter cake was washed with MeOH (3?4 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel, mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 60% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (16 mg, 29%) as a white solid. MS ESI calculated for C.sub.26H.sub.21F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 512.13, found 512.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.46-8.40 (m, 1H), 7.82 (d, J=8.5 Hz, 1H), 7.72 (d, J=1.8 Hz, 1H), 7.64-7.51 (m, 3H), 7.48-7.40 (m, 2H), 7.38-7.33 (m, 1H), 7.32-7.29 (m, 1H), 6.82 (t, J=73.3 Hz, 1H), 6.39 (d, J=7.2 Hz, 1H), 5.00 (t, J=6.6 Hz, 1H), 3.55-3.45 (m, 1H), 2.89 (d, J=13.3 Hz, 1H), 1.81 (s, 3H), 1.78 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.04, ?80.49, ?81.15, ?81.59, ?116.63. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.04.

Example 32: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-methylphenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0414] ##STR00269##

[0415] To a solution of 1-bromo-4-(dimethylphosphoryl)-2-methylbenzene (29 mg, 0.118 mmol) and (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.107 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (68 mg, 0.321 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol). After stirring for 1 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered, and the filter cake was washed with MeOH (3?5 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 60% gradient in 10 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-methylphenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (39 mg, 70%) as a white solid. MS ESI calculated for C.sub.27H.sub.24F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 508.15, found 508.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.49-8.42 (m, 1H), 7.79 (d, J=8.4 Hz, 1H), 7.70 (d, J=12.0 Hz, 1H), 7.61-7.51 (m, 1H), 7.54-7.49 (m, 1H), 7.49-7.41 (m, 2H), 7.39-7.31 (m, 2H), 7.23 (d, J=8.0 Hz, 1H), 6.77 (t, J=72.6 Hz, 1H), 6.37 (d, J=6.6 Hz, 1H), 5.10 (s, 1H), 3.56-3.48 (m, 1H), 2.90 (d, J=13.1 Hz, 1H), 2.29 (s, 3H), 1.81 (s, 3H), 1.77 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.32, ?80.77, ?80.80, ?81.25. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.88.

Example 33: (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methyl]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0416] ##STR00270##

Preparation 33A: 1-bromo-4-[(dimethylphosphoryl)methyl]benzene

[0417] ##STR00271##

[0418] A solution of (methylphosphonoyl)methane (172 mg, 2.201 mmol) in THF (5 mL) was treated with NaHMDS (1 mL, 2.001 mmol, 1N in THF) for 15 min at 0? C. under nitrogen atmosphere followed by the addition of 1-bromo-4-(bromomethyl)benzene (500 mg, 2.001 mmol) in THF (3 mL) dropwise at 0? C. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The reaction was quenched with water at 0? C. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layers were washed with brine (2?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 1-bromo-4-[(dimethylphosphoryl)methyl]benzene (240 mg, 48%) as a white solid. MS ESI calculated for C.sub.9H.sub.12BrOP [M+H].sup.+, 246.98 248.98, found 247.05 249.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.51-7.42 (m, 2H), 7.18-7.09 (m, 2H), 3.12 (d, J=14.9 Hz, 2H), 1.47 (s, 3H), 1.44 (s, 3H).

Example 33: (1R,11R)-18-(difluoromethoxy)-5-(4-[(dimethylphosphoryl)methyl]phenyl)-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0419] ##STR00272##

[0420] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (51 mg, 0.107 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]benzene (22 mg, 0.089 mmol) in 1,4-dioxane (2 mL) were added K.sub.3PO.sub.4 (57 mg, 0.267 mmol) in H.sub.2O (0.5 mL) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (7 mg, 0.009 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30 B to 50 B in 30 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methyl]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (28 mg, 59%) as a white solid. MS ESI calculated for C.sub.28H.sub.26F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 522.17, found 522.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.46 (m, 1H), 7.80-7.75 (m, 1H), 7.69 (d, J=1.7 Hz, 1H), 7.57 (d, J=7.8 Hz, 2H), 7.52-7.46 (m, 1H), 7.42 (t, J=8.2 Hz, 1H), 7.37-7.28 (m, 3H), 6.84 (t, J=72.8 Hz, 1H), 6.29 (d, J=7.1 Hz, 1H), 5.00 (d, J=7.0 Hz, 1H), 3.54 (s, 3H), 3.52-3.42 (m, 1H), 3.21 (d, J=15.1 Hz, 2H), 2.89 (d, J=13.5 Hz, 1H), 1.51 (s, 3H), 1.48 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.20, ?80.64, ?80.86, ?81.30. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.86.

Example 34: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0421] ##STR00273##

Preparation 34A: 1-bromo-4-(dimethylphosphoryl)-2,3-difluorobenzene

[0422] ##STR00274##

[0423] To a stirred mixture of 1-bromo-2,3-difluoro-4-iodobenzene (1.00 g, 3.136 mmol) and (methylphosphonoyl)methane (0.27 g, 3.450 mmol) in 1,4-dioxane (10 mL) were added K.sub.3PO.sub.4 (0.80 g, 3.763 mmol), XantPhos (0.18 g, 0.314 mmol) and Pd.sub.2(dba).sub.3 (0.14 g, 0.157 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15:1) to afford 1-bromo-4-(dimethylphosphoryl)-2,3-difluorobenzene (650 mg, 77%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.8BrF.sub.2OP [M+H].sup.+, 268.95 270.94, found 268.80 270.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.70-7.59 (m, 1H), 7.52 (m, J=8.1, 5.5 Hz, 1H), 1.85 (s, 3H), 1.81 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 30.19.

Example 34: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0424] ##STR00275##

[0425] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.107 mmol) and 1-bromo-4-(dimethylphosphoryl)-2,3-difluorobenzene (43 mg, 0.161 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (37 mg, 0.268 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (17 mg, 30%) as a white solid. MS ESI calculated for C.sub.26H.sub.20F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 530.12, found 529.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47-8.41 (m, 1H), 7.87-7.70 (m, 3H), 7.50-7.34 (m, 4H), 7.29 (d, J=6.2 Hz, 1H), 6.84 (t, J=72.6 Hz, 1H), 6.41 (d, J=7.1 Hz, 1H), 5.06 (t, J=6.4 Hz, 1H), 3.58-3.45 (m, 1H), 2.90 (d, J=13.3 Hz, 1H), 1.89 (s, 3H), 1.86 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.28, ?80.73, ?81.05, ?81.49, ?131.17, ?131.18, ?131.23, ?131.24, ?143.47, ?143.49, ?143.53, ?143.55. .sup.31P NMR (162 MHz, Chloroform-d) ? 29.81.

Example 35: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0426] ##STR00276##

Preparation 35A: 5-bromo-2-(dimethylphosphoryl)-1,3-difluorobenzene

[0427] ##STR00277##

[0428] To a stirred mixture of (methylphosphonoyl)methane (0.27 g, 3.450 mmol) and 5-bromo-1,3-difluoro-2-iodobenzene (1.00 g, 3.136 mmol) in 1,4-dioxane (10 mL) were added K.sub.3PO.sub.4 (0.80 g, 3.763 mmol), XantPhos (0.18 g, 0.314 mmol) and Pd.sub.2(dba).sub.3 (0.14 g, 0.157 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 60? C. under nitrogen atmosphere. The reaction was quenched with sat. NaHCO.sub.3 (aq.) at room temperature. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?50 mL). The combined organic layers were washed with brine (2?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20/1) to afford 5-bromo-2-(dimethylphosphoryl)-1,3-difluorobenzene (170 mg, 20%) as a brown yellow solid. MS ESI calculated for C.sub.8H.sub.8BrF.sub.2OP [M+H].sup.+, 268.95 270.94, found 268.80 270.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.23-7.14 (m, 2H), 1.93 (t, J=1.8 Hz, 3H), 1.89 (t, J=1.8 Hz, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 30.03.

Example 35: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0429] ##STR00278##

[0430] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.107 mmol) and 5-bromo-2-(dimethylphosphoryl)-1,3-difluorobenzene (43 mg, 0.161 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (37 mg, 0.268 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) to followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (17 mg, 30%) as a white solid. MS ESI calculated for C.sub.26H.sub.20F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 530.12, found 529.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.46-8.42 (m, 1H), 7.83 (d, J=8.5 Hz, 1H), 7.69 (d, J=1.8 Hz, 1H), 7.49-7.43 (m, 2H), 7.42-7.35 (m, 2H), 7.22-7.15 (m, 2H), 6.89 (t, J=72.8 Hz, 1H), 6.41 (d, J=7.1 Hz, 1H), 5.04 (t, J=6.6 Hz, 1H), 3.59-3.47 (m, 1H), 2.90 (d, J=13.4 Hz, 1H), 1.98 (s, 3H), 1.94 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.45, ?80.90, ?81.03, ?81.48, ?101.77. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.76.

Example 36: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0431] ##STR00279##

[0432] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 1-bromo-4-(dimethylphosphoryl)-2,3-difluorobenzene (42 mg, 0.156 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.260 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (17 mg, 31%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.47 (m, 1H), 7.86-7.71 (m, 3H), 7.50-7.36 (m, 3H), 7.34-7.29 (m, 1H), 6.82 (t, J=72.8 Hz, 1H), 6.31 (d, J=7.1 Hz, 1H), 5.03 (d, J=7.0 Hz, 1H), 3.54 (s, 3H), 3.53-3.44 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 1.89 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.11, ?80.56, ?81.01, ?81.45, ?131.22, ?131.23, ?131.28, ?131.29, ?143.47, ?143.48, ?143.53, ?143.54. .sup.31P NMR (162 MHz, Chloroform-d) ? 29.83.

Example 37: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0433] ##STR00280##

[0434] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 5-bromo-2-(dimethylphosphoryl)-1,3-difluorobenzene (42 mg, 0.156 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.260 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (22 mg, 39%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 7.82 (d, J=8.5 Hz, 11H), 7.73 (d, J=1.7 Hz, 1H), 7.52-7.41 (m, 2H), 7.36-7.30 (m, 1H), 7.24-7.16 (m, 2H), 6.88 (t, J=72.9 Hz, 1H), 6.32 (d, J=7.1 Hz, 1H), 5.06 (d, J=7.0 Hz, 1H), 3.55 (s, 3H), 3.54-3.45 (m, 1H), 2.92 (d, J=13.6 Hz, 1H), 1.98 (s, 3H), 1.94 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.38, ?80.83, ?80.91, ?81.36, ?101.70. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.80.

Example 38: (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0435] ##STR00281##

Preparation 38A: 1-bromo-4-[(dimethylphosphoryl)methoxy]benzene

[0436] ##STR00282##

[0437] A solution of 4-bromophenol (200 mg, 1.156 mmol) in MeCN (4 mL) was treated with K.sub.2CO.sub.3 (367 mg, 3.468 mmol) and NaI (17 mg, 0.116 mmol) for 10 min at room temperature followed by the addition of chloro(dimethylphosphoryl)methane (146 mg, 1.156 mmol) dropwise at room temperature. The resulting mixture was stirred for 48 h at 80? C. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12:1) to afford 1-bromo-4-[(dimethylphosphoryl)methoxy]benzene (190 mg, 62.48%) as an off-white solid. MS ESI calculated for C.sub.9H.sub.12BrO.sub.2P [M+H].sup.+, 262.98 264.98, found 262.80 264.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.46-7.38 (m, 2H), 6.87-6.78 (m, 2H), 4.21 (d, J=8.3 Hz, 2H), 1.68 (s, 3H), 1.64 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 42.12.

Example 38. (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0438] ##STR00283##

[0439] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.104 mmol) and 1-bromo-4-[(dimethylphosphoryl)methoxy]benzene (41 mg, 0.156 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.260 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (20 mg, 35%) as a white solid. MS ESI calculated for C.sub.28H.sub.26F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 538.16, found 538.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 7.77 (d, J=8.5 Hz, 1H), 7.66 (d, J=1.7 Hz, 1H), 7.59-7.52 (m, 2H), 7.48-7.39 (m, 2H), 7.30 (d, J=8.3 Hz, 1H), 7.08-6.99 (m, 2H), 6.74 (t, J=72.9 Hz, 1H), 6.30 (d, J=7.1 Hz, 1H), 5.02 (d, J=7.0 Hz, 1H), 4.30 (d, J=8.3 Hz, 2H), 3.54 (s, 3H), 3.52-3.41 (m, 1H), 2.89 (d, J=13.5 Hz, 1H), 1.70 (s, 3H), 1.67 (s, 3H). .sup.191F NMR (377 MHz, Chloroform-d) ? ?80.14, ?80.59, ?80.67, ?81.12. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.08.

Example 39: (1R,11R)-18-(difluoromethoxy)-5-{6-[2-(dimethylphosphoryl)ethoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0440] ##STR00284##

Preparation 39A: {[2-(dimethylphosphoryl)ethoxy]methyl}benzene

[0441] ##STR00285##

[0442] To a stirred solution of (methylphosphonoyl)methane (1.81 g, 23.246 mmol) in THF (20 mL) was added NaHMDS (11.62 mL, 23.246 mmol, 2N in THF) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 15 min at room temperature under nitrogen atmosphere. A solution of [(2-bromoethoxy)methyl]benzene (5.00 g, 23.246 mmol) in THF (30 mL) was added above solution dropwise at room temperature under nitrogen atmosphere. The resulting mixture was stirred for overnight at room temperature under nitrogen atmosphere. The reaction was quenched with water at room temperature. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layers were washed with brine (1?200 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (7/1) to afford {[2-(dimethylphosphoryl)ethoxy]methyl}benzene (3.44 g, 69%) as a colorless liquid. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.38-7.28 (m, 5H), 4.53 (s, 2H), 3.87-3.79 (m, 2H), 2.09 (t, J=6.2 Hz, 2H), 1.55 (s, 3H), 1.52 (s, 3H).

Preparation 39B: 2-(dimethylphosphoryl)ethanol

[0443] ##STR00286##

[0444] To a solution of {[2-(dimethylphosphoryl)ethoxy]methyl}benzene (3.44 g, 16.209 mmol) in 30 mL MeOH was added Pd/C (10/a, 300 mg) under nitrogen atmosphere in a 100 mL round-bottom flask. The mixture was hydrogenated at room temperature for overnight under hydrogen atmosphere using a hydrogen balloon, filtered through a celite pad and concentrated under reduced pressure to afford 2-(dimethylphosphoryl)ethanol (1.95 g, 98%) as a colorless oil. .sup.1H NMR (400 MHz, Chloroform-d) 4.76 (s, 1H), 4.09-4.01 (m, 2H), 2.05-1.99 (m, 2H), 1.59 (s, 3H), 1.56 (s, 3H).

Preparation 39C: 5-bromo-2-[2-(dimethylphosphoryl)ethoxy]pyridine

[0445] ##STR00287##

[0446] To a stirred solution of 2-(dimethylphosphoryl)ethanol (300 mg, 2.457 mmol) in THF (3 mL) was added NaH (117 mg, 2.948 mmol, 60%) at 0? C. The resulting mixture was stirred for 15 min at room temperature. To the above mixture was added 5-bromo-2-fluoropyridine (432 mg, 2.457 mmol) dropwise at 0? C. The resulting mixture was stirred for additional 2 h at room temperature. The reaction was quenched with water at 0? C. The resulting mixture was extracted with EtOAc (3?20 mL). The combined organic layers were washed with water (2?10 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8/1) to afford 5-bromo-2-[2-(dimethylphosphoryl)ethoxy]pyridine (187 mg, 27%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.13BrNO.sub.2P [M+H].sup.+, 277.99 279.99, found 278.00 279.00. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.21 (d, J=2.4 Hz, 1H), 7.70-7.66 (m, 1H), 6.67 (d, J=8.8 Hz, 1H), 4.71-4.61 (m, 2H), 2.38-2.27 (m, 2H), 1.64 (s, 3H), 1.59 (s, 3H).

Example 39: (1R,11R)-18-(difluoromethoxy)-5-{6-[2-(dimethylphosphoryl)ethoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0447] ##STR00288##

[0448] A mixture of 5-bromo-2-[2-(dimethylphosphoryl)ethoxy]pyridine (31 mg, 0.114 mmol), (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol), Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) and K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 2 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{6-[2-(dimethylphosphoryl)ethoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (24 mg, 42%) as a white solid. MS ESI calculated for C.sub.28H.sub.27F.sub.2N.sub.4O.sub.4P [M+H].sup.+, 553.17, found 553.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 8.36 (d, J=2.2 Hz, 1H), 7.83-7.76 (m, 2H), 7.65-7.61 (m, 1H), 7.42 (t, J=8.2 Hz, 2H), 7.31 (d, J=7.9 Hz, 1H), 7.04-6.65 (m, 2H), 6.29 (d, J=7.1 Hz, 1H), 5.00 (d, J=7.0 Hz, 1H), 4.77-4.67 (m, 2H), 3.54 (s, 3H), 3.51-3.44 (m, 1H), 2.89 (d, J=13.6 Hz, 1H), 2.37-2.30 (m, 2H), 1.63 (s, 3H), 1.60 (s, 3H); .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.18, ?80.63, ?80.74, ?81.19. .sup.31P NMR (162 MHz, Chloroform-d) 40.68.

Example 40: (1R,11R)-18-(difluoromethoxy)-5-{6-[3-(dimethylphosphoryl)propoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0449] ##STR00289##

Preparation 40A: {[3-(dimethylphosphoryl)propoxy]methyl}benzene

[0450] ##STR00290##

[0451] To a stirred solution of (methylphosphonoyl)methane (0.68 g, 8.729 mmol) in THF (30 mL) was added NaHMDS (4.36 mL, 8.729 mmol, 2N in THF) dropwise at about 0? C. under nitrogen atmosphere. The mixture was stirred for <15 min. The above mixture was added to [(3-bromopropoxy)methyl]benzene (2.00 g, 8.729 mmol) in THF (30 mL) dropwise over 2 min at room temperature. The resulting mixture was stirred for additional 16 h at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford [(3-(dimethyl phosphoryl)propoxy]methyl)benzene (1.20 g, 60%) as a colorless oil. MS ESI calculated for C.sub.12H.sub.19O.sub.2P [M+H].sup.+, 227.11, found 226.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.38-7.28 (m, 5H), 4.51 (s, 2H), 3.56 (t, J=5.8 Hz, 2H), 1.98-1.79 (m, 4H), 1.50 (s, 3H), 1.47 (s, 3H).

Preparation 40B: 3-(dimethylphosphoryl)propan-1-ol

[0452] ##STR00291##

[0453] To a solution of {[3-(dimethylphosphoryl)propoxy]methyl}benzene (1.80 g, 7.956 mmol) in MeOH (20 mL) was added Pd/C (0.42 g, 0.398 mmol, 10%) under nitrogen atmosphere. The mixture was hydrogenated at room temperature for overnight under hydrogen atmosphere using a hydrogen balloon, filtered through a celite pad and concentrated under reduced pressure. This resulted in 3-(dimethylphosphoryl)propan-1-ol (1.00 g, 92%) as a colorless oil. .sup.1H NMR (400 MHz, Chloroform-d) ? 3.72 (t, J=5.3 Hz, 2H), 1.96-1.83 (m, 4H), 1.55 (s, 3H), 1.52 (s, 3H).

Preparation 40C: 5-bromo-2-[3-(dimethylphosphoryl)propoxy]pyridine

[0454] ##STR00292##

[0455] To a solution of 3-(dimethylphosphoryl)propan-1-ol (300 mg, 2.204 mmol) in DMF (10 mL) was added NaH (105 mg, 2.645 mmol, 60%) at 0 degrees C. The mixture was stirred for 15 min. 5-bromo-2-fluoropyridine (388 mg, 2.204 mmol) was added and the mixture was allowed to warm to room temperature and stirred for 2 h. The reaction mixture was quenched by water and purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 10% to 50% gradient in 20 min; detector, 254 nm. This resulted in 5-bromo-2-[3-(dimethylphosphoryl)propoxy]pyridine (380 mg, 59%) as a colorless oil. MS ESI calculated for C.sub.10H.sub.15BrNO.sub.2P [M+H].sup.+, 292.00 294.00 found 291.80 293.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.17 (d, J=2.3 Hz, 1H), 7.66-7.63 (m, 1H), 6.65 (d, J=8.8 Hz, 1H), 4.35 (t, J=6.2 Hz, 2H), 2.15-2.05 (m, 2H), 1.92-1.85 (m, 2H), 1.54 (s, 3H), 1.51 (s, 3H).

Example 40: (1R,11R)-18-(difluoromethoxy)-5-{6-[3-(dimethylphosphoryl)propoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0456] ##STR00293##

[0457] A mixture of 5-bromo-2-[3-(dimethylphosphoryl)propoxy]pyridine (33 mg, 0.114 mmol), (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol), Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) and K.sub.3PO.sub.4 (66 mg, 0.312 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 2 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{6-[3-(dimethylphosphoryl)propoxy]pyridin-3-yl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (20 mg, 34%) as a white solid. MS ESI calculated for C.sub.29H.sub.29F.sub.2N.sub.4O.sub.4P [M+H].sup.+, 567.19, found 567.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.47 (m, 1H), 8.35 (d, J=2.3 Hz, 1H), 7.81-7.78 (m, 2H), 7.66-7.62 (m, 1H), 7.45-7.41 (m, 2H), 7.31 (d, J=7.9 Hz, 1H), 7.04-6.64 (m, 2H), 6.31 (d, J=7.1 Hz, 1H), 5.04 (d, J=7.1 Hz, 1H), 4.44 (t, J=6.1 Hz, 2H), 3.55 (s, 3H), 3.53-3.45 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 2.19-2.10 (m, 2H), 1.96-1.90 (m, 2H), 1.55 (s, 3H), 1.52 (s, 3H); .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.20, ?80.64, ?80.77, ?81.21. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.25.

Example 41: (1R,11R)-5-[2-chloro-4-(dimethylphosphoryl)phenyl]-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0458] ##STR00294##

[0459] To a solution of 1-bromo-2-chloro-4-(dimethylphosphoryl)benzene (31 mg, 0.118 mmol) and (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.107 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (68 mg, 0.321 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol). After stirring for 1 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered, and the filter cake was washed with MeOH (3?4 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 60% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-5-[2-chloro-4-(dimethylphosphoryl)phenyl]-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (23 mg, 41%) as a white solid. MS ESI calculated for C.sub.26H.sub.21ClF.sub.2N.sub.3O.sub.3P [M+H].sup.+, 528.10, found 527.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47-8.41 (m, 1H), 7.89-7.78 (m, 2H), 7.72-7.65 (m, 1H), 7.61 (d, J=1.6 Hz, 1H), 7.51-7.41 (m, 2H), 7.39-7.32 (m, 2H), 6.79 (t, J=72.6 Hz, 1H), 6.39 (d, J=7.2 Hz, 1H), 5.07 (t, J=6.6 Hz, 1H), 3.57-3.44 (m, 1H), 2.90 (d, J=13.3 Hz, 1H), 1.82 (s, 3H), 1.79 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.23, ?80.68, ?80.99, ?81.43. .sup.31P NMR (162 MHz, Chloroform-d) 33.28.

Example 42: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]-1,3-thiazol-5-yl}-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0460] ##STR00295##

Preparation 42A: 5-bromo-2-[(dimethylphosphoryl)methoxy]-1,3-thiazole

[0461] ##STR00296##

[0462] To a stirred solution of (dimethylphosphoryl)methanol (272 mg, 2.519 mmol) in DMF (5 mL) was added NaH (111 mg, 2.771 mmol, 60%) at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at room temperature under nitrogen atmosphere. To the above mixture was added 5-bromo-2-chloro-1,3-thiazole (500 mg, 2.519 mmol) at 0? C. The resulting mixture was stirred for additional overnight at room temperature. The resulting mixture was quenched with water and extracted with EtOAc (3?50 mL). The organic layers were concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12:1) to afford 5-bromo-2-[(dimethylphosphoryl)methoxy]-1,3-thiazole (135 mg, 20%) as a yellow solid. MS ESI calculated for C.sub.6H.sub.9BrNO.sub.2PS [M+H].sup.+, 269.93 271.93, found 269.95 272.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.07 (s, 1H), 4.74 (d, J=5.8 Hz, 2H), 1.65 (s, 3H), 1.62 (s, 3H).

Example 42: (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]-1,3-thiazol-5-yl}-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0463] ##STR00297##

[0464] To a stirred mixture of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.107 mmol) and 5-bromo-2-[(dimethylphosphoryl)methoxy]-1,3-thiazole (24 mg, 0.089 mmol) in 1,4-dioxane (2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (7 mg, 0.009 mmol) and K.sub.3PO.sub.4 (57 mg, 0.267 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0/6 to 15%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30 B to 50 B in 30 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-{2-[(dimethylphosphoryl)methoxy]-1,3-thiazol-5-yl}-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (15 mg, 32%) as a white solid. MS ESI calculated for C.sub.24H.sub.21F.sub.2N.sub.4O.sub.4PS [M+H].sup.+, 531.10, found 530.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47-8.40 (m, 1H), 7.75-7.67 (m, 1H), 7.60-7.51 (m, 1H), 7.49-7.41 (m, 1H), 7.37-7.24 (m, 3H), 6.88 (t, J=72.8 Hz, 1H), 6.39-6.31 (m, 1H), 4.96 (t, J=6.6 Hz, 1H), 4.85-4.76 (m, 2H), 3.54-3.43 (m, 1H), 2.92-2.83 (m, 1H), 1.69 (s, 3H), 1.65 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.18, ?80.62, ?80.66, ?81.11. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.00.

Example 43: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0465] ##STR00298##

[0466] To a stirred mixture of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.106 mmol) and 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (22 mg, 0.088 mmol) in 1,4-dioxane (2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (7 mg, 0.009 mmol) and K.sub.3PO.sub.4 (56 mg, 0.264 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 15%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30 B to 50 B in 30 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (10 mg, 21%) as a white solid. MS ESI calculated for C.sub.26H.sub.21F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 512.13, found 512.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.44 (d, J=8.0 Hz, 1H), 8.06-8.02 (m, 1H), 7.81 (d, J=7.9 Hz, 1H), 7.73 (s, 1H), 7.56-7.50 (m, 2H), 7.47-7.42 (m, 1H), 7.41-7.30 (m, 2H), 7.06-6.69 (m, 1H), 6.41 (d, J=6.7 Hz, 1H), 5.03 (s, 1H), 3.51 (t, J=7.0 Hz, 1H), 3.01-2.81 (m, 1H), 1.87 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.41, ?80.86, ?80.92, ?81.36, ?105.79. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.56.

Example 44: (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]phenyl}-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0467] ##STR00299##

[0468] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.101 mmol) and 1-bromo-4-[(dimethylphosphoryl)methoxy]benzene (26 mg, 0.101 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added K.sub.3PO.sub.4 (64 mg, 0.303 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)methoxy]phenyl}-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (15 mg, 26%) as a white solid. MS ESI calculated for C.sub.29H.sub.28F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 552.18, found 552.15. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.35-8.29 (m, 1H), 7.85-7.63 (m, 3H), 7.61-7.53 (m, 2H), 7.53-7.41 (m, 3H), 7.18-7.10 (m, 2H), 6.28 (d, J=7.1 Hz, 1H), 5.28 (d, J=7.2 Hz, 1H), 4.36 (d, J=6.7 Hz, 2H), 3.90-3.73 (m, 2H), 3.57-3.45 (m, 1H), 2.78 (d, J=13.6 Hz, 1H), 1.54 (s, 3H), 1.51 (s, 3H), 1.35 (t, J=7.0 Hz, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.72, ?82.64. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 38.42.

Example 45: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0469] ##STR00300##

[0470] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.101 mmol) and 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (25 mg, 0.101 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added K.sub.3PO.sub.4 (64 mg, 0.303 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. The resulting mixture was concentrated under reduced pressure. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (26 mg, 47%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 540.16, found 540.10. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.35-8.28 (m, 1H), 7.89-7.80 (m, 1H), 7.83-7.76 (m, 1H), 7.73 (d, J=8.5 Hz, 1H), 7.71-7.46 (m, 6H), 6.31 (d, J=7.0 Hz, 1H), 5.30 (d, J=7.2 Hz, 1H), 3.89-3.76 (m, 2H), 3.58-3.48 (m, 1H), 2.80 (d, J=13.7 Hz, 1H), 1.76 (s, 3H), 1.73 (s, 3H), 1.35 (t, J=7.0 Hz, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.77, ?82.23, ?82.38, ?82.83, ?105.69. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 28.34.

Example 46: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0471] ##STR00301##

[0472] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.101 mmol) and 5-bromo-2-(dimethylphosphoryl)-1,3-difluorobenzene (27 mg, 0.101 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added K.sub.3PO.sub.4 (64 mg, 0.303 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature. The resulting mixture was stirred for 16 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3,5-difluorophenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (19 mg, 34%) as a white solid. MS ESI calculated for C.sub.28H.sub.24F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 558.15, found 558.10. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.36-8.27 (m, 1H), 7.92-7.69 (m, 3H), 7.66-7.61 (m, 1H), 7.55-7.44 (m, 4H), 6.31 (d, J=7.0 Hz, 1H), 5.31 (d, J=7.3 Hz, 1H), 3.90-3.75 (m, 2H), 3.57-3.48 (m, 1H), 2.80 (d, J=13.8 Hz, 1H), 1.88 (s, 3H), 1.84 (s, 3H), 1.35 (t, J=7.0 Hz, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.82, ?82.27, ?82.49, ?82.95, ?102.26. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 29.10.

Example 47: (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0473] ##STR00302##

Preparation 47A: (1R,11R)-5-chloro-12-cyclopropyl-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8), 4,6,9,14(19), 15,17-heptaen-13-one

[0474] ##STR00303##

[0475] To a solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19), 15,17-heptaen-13-one (320 mg, 0.852 mmol) and cyclopropylboronic acid (146 mg, 1.704 mmol) in Toluene (10 mL) were added Na.sub.2CO.sub.3 (135 mg, 1.278 mmol) and copper(I) acetate (157 mg, 1.278 mmol) at room temperature. The mixture was purged with nitrogen for 5 min and then was pressurized to 1?2 atoms with oxygen gas at 80? ? C. for 2 days. The reaction mixture was cooled to room temperature and filtered to remove insoluble solids. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (1:1) to afford (1R,11R)-5-chloro-12-cyclopropyl-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19), 15,17-heptaen-13-one (210 mg, 59%) as a light yellow solid. MS ESI calculated for C.sub.21H.sub.16ClF.sub.2N.sub.3O.sub.2 [M+H].sup.+, 416.09, found 415.90. .sup.1H NMR (400 MHZ, Chloroform-d) ? 8.39-8.33 (m, 1H), 7.66-7.57 (m, 1H), 7.52-7.44 (m, 1H), 7.40 (t, J=8.2 Hz, 1H), 7.34-7.24 (m, 1H), 7.23-7.15 (m, 1H), 6.81 (t, J=72.7 Hz, 1H), 6.22-6.12 (m, 1H), 5.25-5.16 (m, 1H), 3.49-3.36 (m, 1H), 3.29-3.18 (m, 1H), 2.82 (d, J=13.5 Hz, 1H), 1.53-1.41 (m, 1H), 1.14-1.02 (m, 2H), 0.76-0.60 (m, 1H).

Preparation 47B: (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0476] ##STR00304##

[0477] To a solution of (1R,11R)-5-chloro-12-cyclopropyl-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (210 mg, 0.505 mmol) and BPD (192 mg, 0.758 mmol) in 1,4-dioxane (8 mL) were added potassium acetate (149 mg, 1.515 mmol), PCy.sub.3.Math.HBF.sub.4 (28 mg, 0.076 mmol) and Pd.sub.2(dba).sub.3 (46 mg, 0.051 mmol). After stirring for 16 h at 140? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The residue was purified by Prep-TLC, eluted with PE/EA (1:1) to afford (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (250 mg, 97%) as a light yellow oil. MS ESI calculated for C.sub.27H.sub.28BF.sub.2N.sub.3O.sub.4 [M+H].sup.+, 508.21, found 508.15.

Example 47. (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0478] ##STR00305##

[0479] A solution of (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.118 mmol), 5-bromo-2-(dimethylphosphoryl)pyridine (41 mg, 0.177 mmol), K.sub.3PO.sub.4 (75 mg, 0.354 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.012 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) was stirred for 2 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 55% B in 20 min; 254/220 nm to afford (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-[6-(dimethylphosphoryl)pyridin-3-yl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (21 mg, 33%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 535.16, found 535.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.95 (d, J=2.2 Hz, 1H), 8.40-8.34 (m, 1H), 8.24-8.16 (m, 1H), 8.06-8.00 (m, 1H), 7.85 (d, J=8.4 Hz, 1H), 7.76 (d, J=1.7 Hz, 1H), 7.53-7.47 (m, 1H), 7.41 (t, J=8.2 Hz, 1H), 7.33-7.28 (m, 1H), 6.83 (t, J=72.9 Hz, 1H), 6.28 (d, J=7.0 Hz, 1H), 5.27 (d, J=7.2 Hz, 1H), 3.56-3.44 (m, 1H), 3.31-3.24 (m, 1H), 2.88 (d, J=13.5 Hz, 1H), 1.84 (s, 3H), 1.81 (s, 3H), 1.57-1.48 (m, 1H), 1.16-1.08 (m, 2H), 0.74-0.66 (m, 1H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.28, ?80.72, ?80.81-81.26. .sup.31P NMR (162 MHz, Chloroform-d) ? 36.29.

Example 48: (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0480] ##STR00306##

[0481] A mixture of (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.118 mmol), 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (44 mg, 0.177 mmol), K.sub.3PO.sub.4 (75 mg, 0.354 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.012 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) was stirred for 2 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min, 254/220 nm to afford (1R,11R)-12-cyclopropyl-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (20 mg, 30%) as a white solid. MS ESI calculated for C.sub.29H.sub.25F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 552.16, found 552.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.39-8.34 (m, 1H), 8.08-7.98 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.76 (d, J=1.8 Hz, 1H), 7.59-7.52 (m, 1H), 7.56-7.43 (m, 1H), 7.46-7.26 (m, 3H), 6.84 (t, J=72.9 Hz, 1H), 6.27 (d, J=7.0 Hz, 1H), 5.26 (d, J=7.4 Hz, 1H), 3.53-3.42 (m, 1H), 3.31-3.22 (m, 1H), 2.91-2.83 (m, 1H), 1.86 (s, 3H), 1.82 (s, 3H), 1.59-1.43 (m, 1H), 1.16-1.06 (m, 2H), 0.73-0.66 (m, 1H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.25, ?80.70, ?80.87, ?81.32, ?105.83. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.34.

Example 49: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)phenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0482] ##STR00307##

Preparation 49A: 1-bromo-4-(dimethylphosphoryl)benzene

[0483] ##STR00308##

[0484] To a stirred solution of 4-bromoiodobenzene (20.00 g, 70.695 mmol) and (methylphosphonoyl)methane (5.52 g, 70.695 mmol) in 1,4-dioxane (500 mL) were added XantPhos (4.09 g, 7.069 mmol), Et.sub.3N (8.58 g, 84.834 mmol) and Pd.sub.2(dba).sub.3 (3.24 g, 3.535 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 4 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 1-bromo-4-(dimethylphosphoryl)benzene (14.01 g, 85%) as a yellow solid. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.63-7.50 (m, 4H), 1.71 (s, 3H), 1.67 (s, 3H).

Example 49: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)phenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0485] ##STR00309##

[0486] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-12-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.101 mmol) and 1-bromo-4-(dimethylphosphoryl)benzene (23 mg, 0.101 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added K.sub.3PO.sub.4 (64 mg, 0.303 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) at room temperature. The resulting mixture was stirred for 2 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel, mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)phenyl]-12-ethyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (27 mg, 51%) as a white solid. MS ESI calculated for C.sub.28H.sub.26F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 522.17, found 522.10. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.36-8.29 (m, 1H), 7.93-7.63 (m, 7H), 7.59-7.53 (m, 1H), 7.52-7.45 (m, 2H), 6.31 (d, J=7.0 Hz, 1H), 5.30 (d, J=7.2 Hz, 1H), 3.93-3.75 (m, 2H), 3.58-3.47 (m, 1H), 2.80 (d, J=13.7 Hz, 1H), 1.71 (s, 3H), 1.68 (s, 3H), 1.36 (t, J=7.0 Hz, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.68, ?82.13, ?82.19, ?82.64. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 32.30.

Example 50: (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)amino]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0487] ##STR00310##

Preparation 50A: 4-bromo-N-(dimethylphosphoryl)aniline

[0488] ##STR00311##

[0489] To a solution of 4-bromoaniline (150 mg, 0.872 mmol) in THF (4 mL) was added sodium hydride (60% in oil, 38 mg) at 0 degrees C. The mixture was stirred for 20 min. dimethylphosphinoyl chloride (108 mg, 0.959 mmol) was added and the mixture was allowed to warm to room temperature and stirred for 2 h. The reaction mixture was quenched by water and extracted with DCM (3?10 mL). The resulting mixture was extracted with EtOAc (3?10 mL). The combined organic layers were washed with brine (2?5 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) to afford 4-bromo-N-(dimethylphosphoryl)aniline (37 mg, 17%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.11BrNOP [M+H].sup.+, 247.98 249.98, found 248.00 250.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.37-7.32 (m, 2H), 6.97 (d, J=8.7 Hz, 2H), 5.17 (s, 1H), 1.70 (s, 3H), 1.66 (s, 3H).

Example 50: (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)amino]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0490] ##STR00312##

[0491] To a solution of 4-bromo-N-(dimethylphosphoryl)aniline (28 mg, 0.114 mmol) and (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 100? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-{4-[(dimethylphosphoryl)amino]phenyl}-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (22 mg, 38%) as a white solid. MS ESI calculated for C.sub.27H.sub.25F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 523.16, found 523.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50-8.43 (m, 1H), 7.72 (d, J=8.5 Hz, 1H), 7.59 (d, J=1.7 Hz, 1H), 7.49-7.33 (m, 4H), 7.32-7.25 (m, 1H), 7.17-7.11 (m, 2H), 6.82 (t, J=72.9 Hz, 1H), 6.22 (d, J=7.2 Hz, 1H), 5.26 (d, J=9.4 Hz, 1H), 4.97 (d, J=7.1 Hz, 1H), 3.52 (s, 3H), 3.50-3.42 (m, 1H), 2.86 (d, J=13.5 Hz, 1H), 1.74 (s, 3H), 1.71 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.10, ?80.55, ?80.74, 81.19. .sup.31P NMR (162 MHz, Chloroform-d) ? 34.53.

Example 51: (1R,11R)-5-[4-(diethylphosphoryl)-3-fluorophenyl]-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0492] ##STR00313##

Preparation 51A: 4-bromo-1-(diethylphosphoryl)-2-fluorobenzene

[0493] ##STR00314##

[0494] To a stirred mixture of 4-bromo-2-fluoro-1-iodobenzene (1.00 g, 3.323 mmol) and (ethylphosphonoyl)ethane (0.39 g, 3.655 mmol) in 1,4-dioxane (10 mL) were added TEA (0.40 g, 3.988 mmol), XantPhos (0.19 g, 0.332 mmol) and Pd.sub.2(dba).sub.3 (0.15 g, 0.166 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The mixture was basified to pH 8 with saturated NaHCO.sub.3 (aq.). The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layers were washed with brine (3?50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20/1) to afford 4-bromo-1-(diethylphosphoryl)-2-fluorobenzene (778 mg, 83%) as a yellow solid. MS ESI calculated for C.sub.10H.sub.13BrFOP [M+H].sup.+, 278.99 280.99, found 278.95 280.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.90-7.81 (m, 1H), 7.52-7.47 (m, 1H), 7.33-7.28 (m, 1H), 2.15-1.86 (m, 4H), 1.18-1.06 (m, 6H). .sup.31P NMR (162 MHz, Chloroform-d) ? 42.44.

Example 51. (1R,11R)-5-[4-(diethylphosphoryl)-3-fluorophenyl]-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0495] ##STR00315##

[0496] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3,5,7,9,14,16,18-heptaen-13-one (50 mg, 0.107 mmol) and 4-bromo-1-(diethylphosphoryl)-2-fluorobenzene (36 mg, 0.128 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (37 mg, 0.268 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.011 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-5-[4-(diethylphosphoryl)-3-fluorophenyl]-18-(difluoromethoxy)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (31 mg, 54%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 540.16, found 540.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.46-8.41 (m, 1H), 8.08-8.00 (m, 1H), 7.82 (d, J=8.5 Hz, 1H), 7.74 (d, J=1.7 Hz, 1H), 7.59-7.50 (m, 2H), 7.46 (t, J=8.1 Hz, 1H), 7.38 (d, J=8.1 Hz, 1H), 7.35-7.28 (m, 1H), 6.88 (t, J=72.7 Hz, 1H), 6.41 (d, J=7.2 Hz, 1H), 5.03 (t, J=6.6 Hz, 1H), 3.58-3.46 (m, 1H), 2.90 (d, J=13.3 Hz, 1H), 2.19-1.98 (m, 4H), 1.22-1.10 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.44, ?80.88, ?80.94, ?81.39, ?105.34, ?105.36. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.11.

Example 52: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,3-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0497] ##STR00316##

[0498] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 1-bromo-4-(dimethylphosphoryl)-2,3-difluorobenzene (42 mg, 0.154 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.258 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 45% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,3-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (21 mg, 37%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.46 (m, 1H), 7.86-7.71 (m, 3H), 7.49-7.36 (m, 3H), 7.35-7.29 (m, 1H), 7.03-6.62 (m, 1H), 6.31 (d, J=6.9 Hz, 1H), 5.02 (d, J=6.8 Hz, 1H), 3.55-3.44 (m, 1H), 2.91 (d, J=13.4 Hz, 1H), 1.89 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.11, ?80.56, ?81.00, ?81.45, ?131.22, ?131.23, ?131.28, ?131.29, ?143.47, ?143.48, ?143.53, ?143.54. .sup.31P NMR (162 MHz, Chloroform-d) ? 29.78.

Example 53: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0499] ##STR00317##

[0500] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene (39 mg, 0.154 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (36 mg, 0.258 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 45% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (28 mg, 51%) as a white solid. MS ESI calculated for C.sub.27H.sub.20D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 529.16, found 529.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.47 (m, 1H), 7.84-7.78 (m, 1H), 7.74 (d, J=1.8 Hz, 1H), 7.64-7.50 (m, 3H), 7.49-7.38 (m, 2H), 7.34-7.27 (m, 1H), 6.81 (t, J=73.5 Hz, 1H), 6.30 (d, J=7.2 Hz, 1H), 5.01 (d, J=7.1 Hz, 1H), 3.55-3.48 (m, 1H), 2.90 (d, J=13.5 Hz, 1H), 1.81 (s, 3H), 1.78 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.92, ?80.37, ?81.12, ?81.56, ?116.61, ?116.62, ?116.63. .sup.31P NMR (162 MHz, Chloroform-d) ? 32.93.

Example 54: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0501] ##STR00318##

Preparation 54A: 1-bromo-4-(dimethylphosphoryl)-2,5-difluorobenzene

[0502] ##STR00319##

[0503] To a stirred mixture of 1-bromo-2,5-difluoro-4-iodobenzene (1.00 g, 3.136 mmol) and (methylphosphonoyl)methane (0.27 g, 3.450 mmol) in 1,4-dioxane (10 mL) were added K.sub.3PO.sub.4 (0.80 g, 3.763 mmol), XantPhos (0.18 g, 0.314 mmol) and Pd.sub.2(dba).sub.3 (0.14 g, 0.157 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) to afford 1-bromo-4-(dimethylphosphoryl)-2,5-difluorobenzene (550 mg, 65%) as a brown solid. MS ESI calculated for C.sub.8H.sub.8BrF.sub.2OP [M+H].sup.+, 268.95 270.94, found 268.90 270.90. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.84-7.67 (m, 1H), 7.44-7.33 (m, 1H), 1.84 (d, J=1.2 Hz, 3H), 1.80 (d, J=1.2 Hz, 3H). .sup.31P NMR (121 MHz, Chloroform-d) ? 29.75.

Example 54. (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0504] ##STR00320##

[0505] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 1-bromo-4-(dimethylphosphoryl)-2,5-difluorobenzene (42 mg, 0.154 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (35.67 mg, 0.258 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (20 mg, 35%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.46 (m, 1H), 7.87-7.69 (m, 3H), 7.48-7.39 (m, 2H), 7.32 (d, J=8.1 Hz, 1H), 7.25-7.18 (m, 1H), 6.83 (t, J=72.1 Hz, 1H), 6.31 (d, J=7.2 Hz, 1H), 5.03 (d, J=7.1 Hz, 1H), 3.55-3.45 (m, 1H), 2.91 (d, J=13.6 Hz, 1H), 1.86 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.04, ?80.48, ?81.26, ?81.70, ?111.88, ?111.89, ?111.93, ?111.95, ?122.27, ?122.32. .sup.31P NMR (162 MHz, Chloroform-d) ? 29.76.

Example 55: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0506] ##STR00321## ##STR00322## ##STR00323##

Preparation 55A: Ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-4-fluoro-2-nitrophenyl)amino]propanoate

[0507] ##STR00324##

[0508] To a stirred solution of ethyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate hydrochloride (30.00 g, 80.084 mmol) and 1-chloro-2,5-difluoro-4-nitrobenzene (15.50 g, 80.084 mmol) in ACN (300 mL) was added K.sub.2CO.sub.3 (33.20 g, 240.252 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. The resulting mixture was diluted with water (500 mL). The resulting mixture was extracted with EtOAc (3?800 mL). The combined organic layers were washed with brine (1?800 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (5:1) to afford ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-4-fluoro-2-nitrophenyl)amino]propanoate (30.00 g, 73%) as a yellow solid. MS ESI calculated for C.sub.18H.sub.15BrClF.sub.3N.sub.2O.sub.5 [M+H].sup.+, 510.98 512.98, found 511.00 513.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.78-8.74 (m, 1H), 7.95 (d, J=9.2 Hz, 1H), 7.48-7.44 (m, 1H), 7.21-7.14 (m, 2H), 6.65 (t, J=72.2 Hz, 1H), 5.83-5.77 (m, 1H), 4.15 (q, J=7.1 Hz, 2H), 3.27-3.20 (m, 1H), 2.94-2.89 (m, 1H), 1.23 (t, J=7.1 Hz, 3H).

Preparation 55B: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-4-fluoro-2-nitrophenyl)amino]propanal

[0509] ##STR00325##

[0510] To a stirred solution of ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-4-fluoro-2-nitrophenyl)amino]propanoate (29.00 g, 56.676 mmol) in DCM (300 mL) was added 1.5N of DIBAL-H (45 mL, 68.011 mmol) in toluene dropwise at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 2 h at ?78? C. under nitrogen atmosphere. The reaction was quenched by the addition of sat. NH.sub.4Cl (aq.) (50 mL) at ?78? C. The mixture was allowed to warm up to room temperature. The resulting mixture was filtered, and the filter cake was washed with DCM (3?100 mL). The filtrate was concentrated under reduced pressure. The resulting mixture was extracted with EtOAc (3?500 mL). The combined organic layers were washed with brine (1?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (6:1) to afford (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-4-fluoro-2-nitrophenyl)amino]propanal (16.10 g, 60%) as a yellow solid. MS ESI calculated for C.sub.16H.sub.11BrClF.sub.3N.sub.2O.sub.4 [M+H].sup.+, 466.95 468.95, found 467.00 469.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.81 (s, 1H), 8.68 (d, J=9.1 Hz, 1H), 7.95 (d, J=9.2 Hz, 1H), 7.50-7.43 (m, 1H), 7.22-7.15 (m, 3H), 6.67 (t, J=72.2 Hz, 1H), 5.93-5.87 (m, 1H), 3.54-3.47 (m, 1H), 3.09-3.04 (m, 1H).

Preparation 55C: (4R)-4-[2-bromo-6-(difluoromethoxy)phenyl]-4-[(5-chloro-4-fluoro-2-nitrophenyl)amino]-2-[(trimethylsilyl)oxy]butanenitrile

[0511] ##STR00326##

[0512] To a stirred solution of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-4-fluoro-2-nitrophenyl)amino]propanal (15.00 g, 32.077 mmol) in DCM (150 mL) were added ZnI.sub.2 (1.02 g, 3.208 mmol), TEA (324 mg, 3.208 mmol) and TMSCN (6.36 g, 64.154 mmol) at room temperature. The resulting mixture was stirred for 16 h at room temperature. The resulting mixture was diluted with water (100 mL) and extracted with EtOAc (3?100 mL). The combined organic layers were washed with brine (1?200 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The resulting mixture was used in the next step directly without further purification. MS ESI calculated for C.sub.20H.sub.20BrClF.sub.3N.sub.3O.sub.4Si [M+H].sup.+, 566.00 568.00, found 566.10 568.10.

Preparation 55D: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol

[0513] ##STR00327##

[0514] To a stirred solution of (4R)-4-[2-bromo-6-(difluoromethoxy)phenyl]-4-[(5-chloro-4-fluoro-2-nitrophenyl)amino]-2-[(trimethylsilyl)oxy]butanenitrile (19.00 g, 33.520 mmol) in EtOH (150 mL) was added SnCl.sub.2 (32.12 g, 167.600 mmol) at room temperature. The resulting mixture was stirred for 16 h at room temperature. The resulting mixture was diluted with water (100 mL). The mixture was basified to pH 8 with KOH (1N). The resulting mixture was diluted with EtOAc (500 mL). The resulting mixture was filtered, and the filter cake was washed with EtOAc (3?100 mL). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol (14.02 g, 93%) as a yellow solid. MS ESI calculated for C.sub.17H.sub.11BrClF.sub.3N.sub.2O.sub.2 [M+H].sup.+ 446.96 448.96, found 447.00 449.00.

Preparation 55E: (3R,5S)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol

[0515] ##STR00328##

[0516] The mixture of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol (14 g, 31.275 mmol) was purified by HPLC with the following conditions: Column: XB-C18 101?650 mm, 10 ?m; Mobile Phase A: Water (0.1% TFA), Mobile Phase B: ACN; Flow rate: 350 mL/min; Gradient: 30% B to 50% B in 40 min; 254/220 nm to afford (3R,5S)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol (8.10 g, 57%) as a yellow solid. C.sub.17H.sub.11BrClF.sub.3N.sub.2O.sub.2 [M+H].sup.+, 446.96 448.96, found 447.00 449.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.66-7.47 (m, 2H), 7.43-7.34 (m, 1H), 7.05-5.99 (m, 4H), 5.85-5.77 (m, 1H), 3.41-3.18 (m, 2H).

Preparation 55F: (3R,5R)-5-azido-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraene

[0517] ##STR00329##

[0518] To a stirred solution of (3R,5S)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-ol (6.01 g, 13.404 mmol) and DPPA (4.43 g, 16.085 mmol) in THF (20 mL) was added DBU (10.20 g, 67.020 mmol) at 0? C. The resulting mixture was stirred for 24 h at 30? C. The resulting mixture was diluted with EtOAc (50 mL) and H.sub.2O (100 mL). The resulting mixture was extracted with EtOAc (2?50 mL). The combined organic layers were washed with Sat. NH.sub.4Cl (1?100 mL) and Sat. NaHCO.sub.3 (1?100 mL) and dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The crude product was used in the next step directly without further purification. MS ESI calculated for C.sub.17H.sub.10BrClF.sub.3N.sub.5O [M+H].sup.+, 471.97 473.97, found 471.95 473.95.

Preparation 55G: (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine

[0519] ##STR00330##

[0520] To a stirred solution of (3R,5R)-5-azido-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraene (10 g, crude) in solution of THF (100 mL) and H.sub.2O (10 mL) was added PPh.sub.3 (4.00 g, 15.250 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (5.02 g) as a black oil. MS ESI calculated for C.sub.17H.sub.12BrClF.sub.3N.sub.3O [M+H].sup.+, 445.98 447.98, found 446.00 448.00.

Preparation 55H: (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0521] ##STR00331##

[0522] To a solution of (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-10-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (2.00 g, 4.478 mmol) in 1,4-dioxane (20 mL) were added K.sub.2CO.sub.3 (3.09 g, 22.390 mmol), XantPhos (129 mg, 0.224 mmol) and Pd(OAc).sub.2 (50 mg, 0.224 mmol) in a pressure tank. The mixture was purged with nitrogen for 2 min and then was pressurized to 1 atom with carbon monoxide at 100? C. for 16 h. The reaction mixture was cooled to room temperature and filtered to remove insoluble solids. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (0.70 g, 39%) as a brown solid. MS ESI calculated for C.sub.18H.sub.11ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 394.05 396.05, found 394.00 396.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.44-8.42 (m, 1H), 7.66 (d, J=6.6 Hz, 1H), 7.51-7.38 (m, 4H), 6.85 (t, J=72.6 Hz, 1H), 6.29-6.27 (m, 1H), 4.97-4.93 (m, 1H), 3.50-3.43 (m, 1H), 2.87-2.83 (m, 1H).

Preparation 551: (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0523] ##STR00332##

[0524] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (300 mg, 0.762 mmol) in dry THF (3 mL) was added 1N of KHMDS (0.91 mL, 0.914 mmol) in THF dropwise at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 1 h at ?78? C. under nitrogen atmosphere. To the above mixture was added CH.sub.3I (162 mg, 1.143 mmol) dropwise at ?78? C. The resulting mixture was stirred for additional 16 h at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (220 mg, 70%) as a yellow solid. MS ESI calculated for C.sub.11H.sub.13ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 408.06 410.06, found 408.05 410.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.44 (m, 1H), 7.50-7.42 (m, 3H), 7.34 (d, J=8.2 Hz, 1H), 6.84 (t, J=72.7 Hz, 1H), 6.20-6.18 (m, 1H), 4.96-4.94 (m, 1H), 3.50-3.41 (m, 4H), 2.88-2.85 (m, 1H).

Preparation 55J: (1R,11R)-18-(difluoromethoxy)-6-fluoro-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0525] ##STR00333##

[0526] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (210 mg, 0.515 mmol), KOAc (152 mg, 1.545 mmol) and BPD (196 mg, 0.772 mmol) in 1,4-dioxane (5 mL) were added PCy.sub.3.Math.HBF.sub.4 (19 mg, 0.052 mmol) and Pd.sub.2(dba).sub.3 (47 mg, 0.052 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 140? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (1R,11R)-18-(difluoromethoxy)-6-fluoro-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (210 mg, 81%) as a yellow solid. MS ESI calculated for C.sub.25H.sub.25BF.sub.3N.sub.3O.sub.4 [M+H].sup.+, 500.19, found 500.30.

Example 55: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0527] ##STR00334##

[0528] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-6-fluoro-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (70 mg, 0.140 mmol) and 1-bromo-4-(dimethylphosphoryl)-2,3-difluorobenzene (38 mg, 0.140 mmol) in 1,4-dioxane (2 mL) was added solution of K.sub.3PO.sub.4 (89 mg, 0.420 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above mixture was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (11 mg, 0.014 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: Column: C18 Column 120 g; Mobile Phase A: Water (0.1% FA), Mobile Phase B: ACN; Flow rate: 50 mL/min; Gradient: 25% B to 50% B in 25 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,3-difluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (35 mg, 44%) as a white solid. MS ESI calculated for C.sub.27H.sub.21F.sub.5N.sub.3O.sub.3P [M+H].sup.+, 562.12, found 562.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.82-7.75 (m, 1H), 7.53 (d, J=10.4 Hz, 1H), 7.48 (d, J=6.3 Hz, 1H), 7.44 (t, J=8.2 Hz, 1H), 7.34-7.30 (m, 2H), 6.79 (t, J=72.8 Hz, 1H), 6.26-6.24 (m, 1H), 4.99-4.97 (m, 1H), 3.52-3.44 (m, 4H), 2.91-2.87 (m, 1H), 1.89 (s, 3H), 1.86 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.33, ?80.78, ?80.89, ?81.34, ?120.15, ?120.20, ?131.22, ?131.23, ?131.28, ?131.29, ?139.01, ?139.02, ?139.06, ?139.07, ?139.08, ?139.12, ?139.14. .sup.31P NMR (162 MHz, Chloroform-d) ? 29.90.

Example 56: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,5-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0529] ##STR00335##

[0530] To a solution of (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (50 mg, 0.104 mmol) and 1-bromo-4-(dimethylphosphoryl)-2,5-difluorobenzene (28 mg, 0.104 mmol) in 1,4-dioxane (0.5 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.312 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol). After stirring for 2 h at 80? C. under a nitrogen atmosphere, the resulting mixture was concentrated under reduced pressure. The resulting mixture was filtered, and the filter cake was washed with MeOH (3?5 mL). The filtrate was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,5-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (34 mg, 59%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.05. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.56-8.47 (m, 1H), 7.90-7.73 (m, 3H), 7.52-7.40 (m, 2H), 7.34 (d, J=8.2 Hz, 1H), 7.26-7.20 (m, 1H), 7.14-6.58 (m, 1H), 6.35 (d, J=6.1 Hz, 1H), 5.13-5.04 (m, 1H), 3.62-3.45 (m, 4H), 2.94 (d, J=13.2 Hz, 1H), 1.89 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?79.97, ?80.57, ?81.21, ?81.81, ?111.82, ?111.83, ?111.88, ?111.90, ?122.26, ?122.33. .sup.31P NMR (121 MHz, Chloroform-d) ? 29.66.

Example 57: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0531] ##STR00336##

[0532] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-6-fluoro-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (70 mg, 0.140 mmol) and 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (35 mg, 0.140 mmol) in 1,4-dioxane (2 mL) was added solution of K.sub.3PO.sub.4 (89 mg, 0.420 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (11 mg, 0.014 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional 2 h at 80? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-3-fluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (18 mg, 23%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.47 (m, 1H), 8.07-8.01 (m, 1H), 7.56-7.31 (m, 6H), 6.83 (t, J=73.3 Hz, 1H), 6.29-6.25 (m, 1H), 5.04-4.98 (m, 1H), 3.56-3.47 (m, 4H), 2.93-2.87 (m, 1H), 1.88-1.79 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.81, ?80.90, ?106.04, ?122.36. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.70.

Example 58: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0533] ##STR00337##

[0534] To a stirred solution of (1R,11R)-18-(difluoromethoxy)-6-fluoro-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (70 mg, 0.140 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene (35 mg, 0.140 mmol) in 1,4-dioxane (2 mL) was added solution of K.sub.3PO.sub.4 (89 mg, 0.420 mmol) in H.sub.2O (0.5 mL) at room temperature under nitrogen atmosphere. To the above solution was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (11 mg, 0.014 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for additional 2 h at 80? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (0.1% FA), Mobile Phase B: CH.sub.3CN; Flow rate: 50 mL/min; Gradient: 20 B to 40 B in 40 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2-fluorophenyl]-6-fluoro-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (30 mg, 39/a) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.48 (m, 1H), 7.58-7.28 (m, 7H), 6.78 (t, J=73.0 Hz, 1H), 6.27-6.23 (m, 1H), 5.00-4.96 (m, 1H), 3.55-3.44 (m, 4H), 2.91-2.85 (m, 1H), 1.83-1.78 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.19, ?80.64, ?81.04, ?81.49, ?113.44, ?113.48, ?120.55, ?120.59. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.69.

Example 59: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0535] ##STR00338##

Preparation 59A: (7R,14R)-11-chloro-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0536] ##STR00339##

[0537] To a stirred solution of (1R,11R)-5-chloro-18-(difluoromethoxy)-6-fluoro-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (400 mg, 1.016 mmol) in dry THF (10 mL) was added 1N of KHMDS (1.22 mL, 1.219 mmol) in THF dropwise at ?78? C. under nitrogen atmosphere. The resulting solution was stirred for 1 h at ?78? C. under nitrogen atmosphere. To the above solution was added CD.sub.3I (295 mg, 2.032 mmol) dropwise over 2 min at ?78? C. The resulting mixture was allowed to warm slowly to room temperature. The resulting mixture was stirred for 3 h at room temperature under nitrogen atmosphere. The reaction was quenched by the addition of sat. NH.sub.4Cl (aq.) (5 mL) at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (380 mg, 91%) as an off-white solid. MS ESI calculated for C.sub.19H.sub.10D.sub.3ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 411.08, found 410.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.53-7.42 (m, 3H), 7.37-7.31 (m, 1H), 6.84 (t, J=72.7 Hz, 1H), 6.21 (d, J=7.2 Hz, 1H), 4.97 (d, J=7.2 Hz, 1H), 3.51-3.41 (m, 1H), 2.87 (d, J=13.6 Hz, 1H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.21, ?80.65, ?80.99, ?81.43, ?120.18.

Preparation 59B: (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0538] ##STR00340##

[0539] To a stirred mixture of (7R,14R)-11-chloro-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (380 mg, 0.925 mmol), KOAc (272 mg, 2.775 mmol) and BPD (470 mg, 1.850 mmol) in 1,4-dioxane (10 mL) were added PCy.sub.3.Math.HBF.sub.4 (51 mg, 0.139 mmol) and Pd.sub.2(dba); (85 mg, 0.093 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 140? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with EtOAc/EtOH/PE (3/1/6) to afford (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (370 mg, 80%) as an off-white solid. MS ESI calculated for C.sub.25H.sub.22D.sub.3BF.sub.3N.sub.3O.sub.4 [M+H].sup.+, 503.21, found 503.30.

Example 59: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0540] ##STR00341##

[0541] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.119 mmol) and 4-bromo-1-(dimethylphosphoryl)-2-fluorobenzene (45 mg, 0.178 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (41 mg, 0.297 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.012 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (22 mg, 34%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.46 (m, 1H), 8.10-8.01 (m, 1H), 7.60-7.50 (m, 2H), 7.50-7.41 (m, 2H), 7.37-7.29 (m, 2H), 6.83 (t, J=72.8 Hz, 1H), 6.29 (d, J=7.0 Hz, 1H), 5.05 (d, J=7.0 Hz, 1H), 3.57-3.45 (m, 1H), 2.91 (d, J=13.6 Hz, 1H), 1.87 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.37, ?80.82, ?80.95, ?81.39, ?105.97, ?105.98, ?121.63. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.43.

Example 60: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0542] ##STR00342##

[0543] A mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol), 5-bromo-2-(dimethylphosphoryl)-1,3-difluorobenzene (36 mg, 0.134 mmol), K.sub.2CO.sub.3 (43 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50/6 gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (30 mg, 53%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 7.81 (d, J=8.5 Hz, 1H), 7.72 (d, J=1.8 Hz, 1H), 7.51-7.40 (m, 2H), 7.36-7.29 (m, 1H), 7.24-7.15 (m, 2H), 6.88 (t, J=72.9 Hz, 1H), 6.31 (d, J=7.2 Hz, 1H), 5.02 (d, J=7.1 Hz, 1H), 3.55-3.45 (m, 1H), 2.92 (d, J=13.6 Hz, 1H), 1.98 (s, 3H), 1.94 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.37, ?80.82, ?80.88, ?81.32, ?101.77. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.79.

Example 61: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0544] ##STR00343##

[0545] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.119 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-fluorobenzene (45 mg, 0.178 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.2CO.sub.3 (41 mg, 0.297 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.012 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 40% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (21 mg, 32%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.48 (m, 1H), 7.64-7.49 (m, 5H), 7.45 (t, J=8.2 Hz, 1H), 7.32 (d, J=8.1 Hz, 1H), 6.79 (t, J=72.7 Hz, 1H), 6.30 (d, J=7.1 Hz, 1H), 5.09 (d, J=7.0 Hz, 1H), 3.58-3.47 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 1.82 (s, 3H), 1.79 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.29, ?80.73, ?81.04, ?81.49, ?113.52, ?113.53, ?113.56, ?113.57, ?118.96. .sup.31P NMR (162 MHz, Chloroform-d) ? 32.98.

Example 62: (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,6-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0546] ##STR00344##

Preparation 62A: 2-bromo-5-(dimethylphosphoryl)-1,3-difluorobenzene

[0547] ##STR00345##

[0548] A mixture of 2-bromo-1,3-difluoro-5-iodobenzene (1.00 g, 3.136 mmol), (methylphosphonoyl)methane (367 mg, 4.704 mmol), Pd.sub.2(dba).sub.3 (143 mg, 0.157 mmol), XantPhos (181 mg, 0.314 mmol) and TEA (476 mg, 4.704 mmol) in 1,4-dioxane (10 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 2-bromo-5-(dimethylphosphoryl)-1,3-difluorobenzene (500 mg, 59%) as a white solid. MS ESI calculated for C.sub.8H.sub.8BrF.sub.2OP [M+H].sup.+, 268.95, 270.95, found 268.80, 270.80. .sup.1H NMR (300 MHz, DMSO-d.sub.6) ? 7.70-7.60 (m, 2H), 1.73 (s, 3H), 1.69 (s, 3H).

Example 62. (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,6-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one

[0549] ##STR00346##

[0550] A mixture of 2-bromo-5-(dimethylphosphoryl)-1,3-difluorobenzene (40 mg, 0.150 mmol), (1R,11R)-18-(difluoromethoxy)-12-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (60 mg, 0.125 mmol), K.sub.3PO.sub.4 (79 mg, 0.375 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30/6 B to 70% B in 20 min; 254/220 nm to afford (1R,11R)-18-(difluoromethoxy)-5-[4-(dimethylphosphoryl)-2,6-difluorophenyl]-12-methyl-2,9,12-triazapentacyclo[9.8.1.0{circumflex over ()}{2,10}.0{circumflex over ()}{3,8}.0{circumflex over ()}{14,19}]icosa-3(8),4,6,9,14(19),15,17-heptaen-13-one (33 mg, 49%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.05. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.54-8.51 (m, 1H), 7.85 (d, J=8.6 Hz, 1H), 7.67 (s, 1H), 7.49-7.36 (m, 4H), 7.32 (d, J=7.8 Hz, 1H), 7.05-6.57 (m, 1H), 6.32 (d, J=7.2 Hz, 1H), 5.06 (d, J=7.2 Hz, 1H), 3.57 (s, 3H), 3.54-3.47 (m, 1H), 2.93 (d, J=13.7 Hz, 1H), 1.84 (s, 3H), 1.80 (s, 3H); .sup.19F NMR (282 MHz, Chloroform-d) ? ?79.50, ?80.10, ?81.25, ?81.85, ?111.80, ?111.81. .sup.31P NMR (121 MHz, Chloroform-d) ? 32.85.

Example 63: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,6-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0551] ##STR00347##

[0552] A mixture of 2-bromo-5-(dimethylphosphoryl)-1,3-difluorobenzene (53 mg, 0.198 mmol), (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.165 mmol), K.sub.3PO.sub.4 (105 mg, 0.495 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (13 mg, 0.017 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,6-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (22 mg, 23%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.00. .sup.1H NMR (300 MHz, Chloroform-d) ? 8.51-8.49 (m, 1H), 7.83 (d, J=8.6 Hz, 1H), 7.65 (s, 1H), 7.45-7.36 (m, 4H), 7.30 (d, J=7.8 Hz, 1H), 6.96-6.60 (m, 1H), 6.30 (d, J=7.2 Hz, 1H), 5.04 (d, J=7.2 Hz, 1H), 3.53-3.45 (m, 1H), 2.91 (d, J=13.7 Hz, 1H), 1.82 (s, 3H), 1.79 (s, 3H); .sup.19F NMR (282 MHz, Chloroform-d) ? ?79.61, ?80.06, ?81.31, ?81.76, ?111.78, ?111.79. .sup.31P NMR (121 MHz, Chloroform-d) ? 32.82.

Example 64: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0553] ##STR00348##

Preparation 64A: 2-[4-(dimethylphosphoryl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

[0554] ##STR00349##

[0555] To a stirred mixture of 1-bromo-4-(dimethylphosphoryl)benzene (900 mg, 3.862 mmol), bis(pinacolato)diboron (1.27 g, 5.021 mmol) and KOAc (1.14 g, 11.586 mmol) in 1,4-dioxane (10 mL) was added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (141 mg, 0.193 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 12 h at 60? ? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 2-[4-(dimethylphosphoryl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (600 mg, 55%) as a yellow solid. MS ESI calculated for C.sub.14H.sub.22BO.sub.3P [M+H].sup.+, 281.14, found 281.25.

Example 64: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0556] ##STR00350##

[0557] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.122 mmol) and 2-[4-(dimethylphosphoryl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (68 mg, 0.244 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (51 mg, 0.244 mmol), SPhos (5 mg, 0.012 mmol) and SPhos Pd G3 (4 mg, 0.006 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 2 h at 80? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions. Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (38 mg, 58%) as a white solid. MS ESI calculated for C.sub.27H.sub.20D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 529.16, found 529.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.85-7.80 (m, 2H), 7.66 (d, J=8.0 Hz, 2H), 7.57-7.50 (m, 2H), 7.44 (t, J=8.2 Hz, 1H), 7.32 (d, J=8.1 Hz, 1H), 6.81 (t, J=72.8 Hz, 1H), 6.28 (d, J=7.1 Hz, 1H), 5.04 (d, J=7.1 Hz, 1H), 3.55-3.47 (m, 1H), 2.90 (d, J=13.6 Hz, 1H), 1.81 (s, 3H), 1.78 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.84, ?80.85, ?121.98.

Example 65: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0558] ##STR00351##

[0559] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.127 mmol) and 1-[4-(dimethylphosphoryl)phenyl]-3,3,4,4-tetramethyl-1lambda3,2,5-bromadioxolane (88 mg, 0.254 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (54 mg, 0.254 mmol), SPhos (5 mg, 0.013 mmol) and SPhos Pd G3 (4 mg, 0.006 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 2 h at 80? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (40 mg, 61%) as a white solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 511.17, found 511.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.1 Hz, 1H), 7.88-7.68 (m, 6H), 7.55 (d, J=8.4 Hz, 1H), 7.44 (t, 1=8.2 Hz, 1H), 7.32 (d, J=8.2 Hz, 1H), 6.85 (t, J=72.9 Hz, 1H), 6.34 (s, 1H), 5.10 (s, 1H), 3.52 (s, 1H), 2.92 (d, J=12.8 Hz, 1H), 1.81 (s, 3H), 1.78 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.73.

Example 66: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0560] ##STR00352##

[0561] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-10-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (30 mg, 0.076 mmol) and 2-[4-(dimethylphosphoryl)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (30 mg, 0.099 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added SPhos Pd G3 (6 mg, 0.008 mmol), SPhos (6 mg, 0.015 mmol) and K.sub.3PO.sub.4 (48 mg, 0.228 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (17 mg, 41%) as a white solid. MS ESI calculated for C.sub.26H.sub.20F.sub.4N.sub.3O.sub.3P [M+H].sup.+ ?, 530.12, found 530.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.48-8.42 (m, 1H), 8.11-8.02 (m, 1H), 7.67 (d, J=6.5 Hz, 1H), 7.63-7.55 (m, 2H), 7.52-7.28 (m, 4H), 6.85 (t, J=72.6 Hz, 1H), 6.44 (d, J=6.8 Hz, 1H), 5.31-5.20 (m, 1H), 3.67-3.54 (m, 1H), 2.93 (d, J=13.3 Hz, 1H), 1.87 (s, 3H), 1.84 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.41, ?80.86, ?81.21, ?81.64, ?105.78, ?105.79, ?119.77.

Example 67: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0562] ##STR00353##

Preparation 67A: 1-bromo-4-[(dimethylphosphoryl)methyl]-2-fluorobenzene

[0563] ##STR00354##

[0564] A solution of (methylphosphonoyl)methane (160 mg, 2.053 mmol) in THF (4 mL) was treated with 2 M NaHMDS (0.93 mL, 1.866 mmol) for 15 min at 0? C. under nitrogen atmosphere followed by the addition of 1-bromo-4-(bromomethyl)-2-fluorobenzene (500 mg, 1.866 mmol) in THF (1 mL) dropwise at 0? C. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. This reaction was quenched with water at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 1-bromo-4-[(dimethylphosphoryl)methyl]-2-fluorobenzene (96 mg, 19%) as a white solid. MS ESI calculated for C.sub.9H.sub.11BrFOP [M+H].sup.+, 264.97 266.97, found 264.80 266.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.55-7.48 (m, 1H), 7.08-7.05 (m, 1H), 6.97-6.94 (m, 1H), 3.12 (d, J=14.6 Hz, 2H), 1.50 (s, 3H), 1.47 (s, 3H).

Example 67: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0565] ##STR00355##

[0566] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (40 mg, 0.083 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]-2-fluorobenzene (26 mg, 0.100 mmol) in 1,4-dioxane (1 mL) and water (0.2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (7 mg, 0.008 mmol) and K.sub.3PO.sub.4 (53 mg, 0.249 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (17 mg, 37%) as a white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 543.18, found 543.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.49 (d, J=8.2 Hz, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.71 (s, 1H), 7.47-7.39 (m, 3H), 7.36-7.30 (m, 1H), 7.16-7.06 (m, 2H), 7.02-6.63 (m, 1H), 6.31 (d, J=7.0 Hz, 1H), 5.07 (d, J=7.0 Hz, JH), 3.55-3.44 (m, 1H), 3.19 (d, J=14.8 Hz, 2H), 2.90 (d, J=13.5 Hz, 1H), 1.54 (s, 3H), 1.51 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.96, ?80.41, ?81.41, ?81.86, ?117.54. .sup.31P NMR ((162 MHz, Chloroform-d) ? 40.12.

Example 68: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0567] ##STR00356##

Preparation 68A: 4-bromo-1-(bromomethyl)-2-fluorobenzene

[0568] ##STR00357##

[0569] A solution of (4-bromo-2-fluorophenyl)methanol (1.00 g, 4.877 mmol) in HBr in AcOH (5 mL) was stirred for 15 min at 100? C. The mixture was allowed to cool down to room temperature. The residue was basified to pH 7 with 2N NaOH (aq.). The resulting mixture was extracted with CH.sub.2Cl.sub.2 (2?50 mL). The combined organic layers were dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (10/1) to afford 4-bromo-1-(bromomethyl)-2-fluorobenzene (1.27 g, 97%) as a colorless oil. MS ESI calculated for C.sub.7H.sub.5Br.sub.2F [M+H].sup.+, 266.87 268.87 270.87, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.28-7.23 (m, 3H), 4.48-4.44 (m, 2H).

Preparation 68B: 4-bromo-1-[(dimethylphosphoryl)methyl]-2-fluorobenzene

[0570] ##STR00358##

[0571] A solution of (methylphosphonoyl)methane (192.27 mg, 2.463 mmol) in THF (10 mL) was treated with NaHDMS (1.12 mL, 2.239 mmol) for 15 min at 0? C. under nitrogen atmosphere followed by the addition of 4-bromo-1-(bromomethyl)-2-fluorobenzene (600 mg, 2.239 mmol) in portions at 0? C. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The reaction was quenched with Water at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 4-bromo-1-[(dimethylphosphoryl)methyl]-2-fluorobenzene (188 mg, 31%) as a white solid. MS ESI calculated for C.sub.9H.sub.11BrFOP [M+H].sup.+, 264.97 266.97, found 264.80 266.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.30-7.23 (m, 3H), 3.17 (d, J=14.9 Hz, 2H), 1.51 (s, 3H), 1.48 (s, 3H).

Example 68: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0572] ##STR00359##

[0573] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (140 mg, 0.289 mmol) and 4-bromo-1-[(dimethylphosphoryl)methyl]-2-fluorobenzene (92 mg, 0.347 mmol) in 1,4-dioxane (3 mL) and water (0.6 mL) were added Pd(dppf)Cl.sub.2 (24 mg, 0.029 mmol) and K.sub.3PO.sub.4 (184 mg, 0.867 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 35% to 50% gradient in 20 min. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (75 mg, 47%) as a white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 543.18, found 543.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.72-7.68 (m, 1H), 7.51-7.29 (m, 6H), 6.87 (t, J=72.8 Hz, 1H), 6.31 (d, J=7.1 Hz, 1H), 5.05 (d, J=7.0 Hz, 1H), 3.56-3.45 (m, 1H), 3.25 (d, J=15.2 Hz, 2H), 2.91 (d, J=13.6 Hz, 1H), 1.55 (s, 3H), 1.52 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.38, ?80.83, ?80.97, ?81.34, ?116.69, ?116.70. .sup.31P NMR (122 MHz, Chloroform-d) ? 41.27.

Example 69: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0574] ##STR00360##

Preparation 69A: 5-bromo-2-[(dimethylphosphoryl)methyl]-1,3-difluorobenzene

[0575] ##STR00361##

[0576] A solution of (methylphosphonoyl)methane (0.55 g, 6.996 mmol) in THF (10 mL) was treated with 2M NaHMDS (2.62 mL, 5.247 mmol) for 15 min at 0? C. under nitrogen atmosphere followed by the addition of 5-bromo-2-(bromomethyl)-1,3-difluorobenzene (1.00 g, 3.498 mmol) in portions at 0? C. The resulting mixture was stirred for 16 h at room temperature under nitrogen atmosphere. The reaction was quenched with water at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 5-bromo-2-[(dimethylphosphoryl)methyl]-1,3-difluorobenzene (240 mg, 24%) as a white solid. MS ESI calculated for C.sub.9H.sub.10BrF.sub.2OP [M+H].sup.+, 282.96 284.96, found 282.80 284.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.19-7.11 (m, 2H), 3.23 (d, J=15.8 Hz, 2H), 1.54 (s, 3H), 1.50 (s, 3H).

Example 69: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0577] ##STR00362##

[0578] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (200 mg, 0.413 mmol) and 5-bromo-2-[(dimethylphosphoryl)methyl]-1,3-difluorobenzene (234 mg, 0.826 mmol) in 1,4-dioxane (4 mL) and H.sub.2O (0.8 mL) were added Pd(dppf)Cl.sub.2 (34 mg, 0.041 mmol) and K.sub.3PO.sub.4 (263 mg, 1.239 mmol) in portions at room temperature. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 35% to 50% gradient in 20 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (85 mg, 36%) as a white solid. MS ESI calculated for C.sub.29H.sub.21D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 561.17, found 561.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.48 (m, 1H), 7.81 (d, J=8.5 Hz, 1H), 7.72-7.68 (m, 1H), 7.50-7.41 (m, 2H), 7.34 (d, J=8.1 Hz, 1H), 7.17 (d, J=8.3 Hz, 2H), 6.89 (t, J=72.8 Hz, 1H), 6.34 (d, J=7.1 Hz, 1H), 5.11 (d, J=7.1 Hz, 1H), 3.58-3.49 (m, 1H), 3.31 (d, J=16.0 Hz, 2H), 2.93 (d, J=13.6 Hz, 1H), 1.58 (s, 3H), 1.54 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.96, ?112.27. .sup.31P NMR (162 MHz, Chloroform-d) ? 41.93.

Example 70: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0579] ##STR00363##

[0580] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (200 mg, 0.413 mmol) and 5-bromo-2-[(dimethylphosphoryl)methyl]-1,3-difluorobenzene (234 mg, 0.826 mmol) in 1,4-dioxane (4 mL) and H.sub.2O (0.8 mL) were added Pd(dppf)Cl.sub.2 (34 mg, 0.041 mmol) and K.sub.3PO.sub.4 (263 mg, 1.239 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 35% to 50% gradient in 20 min. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (85 mg, 36%) as a white solid. MS ESI calculated for C.sub.28H.sub.23D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 525.19, found 525.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.78 (d, J=8.5 Hz, 1H), 7.71 (s, 1H), 7.60-7.49 (m, 3H), 7.43 (t, J=8.2 Hz, 1H), 7.37-7.29 (m, 3H), 6.85 (t, J=72.8 Hz, 1H), 6.32 (d, J=7.1 Hz, 1H), 5.06 (d, J=7.0 Hz, 1H), 3.56-3.45 (m, 1H), 3.21 (d, J=15.1 Hz, 2H), 2.91 (d, J=13.5 Hz, 1H), 1.52 (s, 3H), 1.48 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.27, ?80.72, ?80.88, ?81.33. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.79.

Example 71: (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0581] ##STR00364##

[0582] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (100 mg, 0.183 mmol) in THF (1.5 mL) was added KHMDS (0.91 mL, 0.915 mmol) dropwise at 0? C. under nitrogen atmosphere. The mixture was stirred for 2 h at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The resulting mixture was concentrated under vacuum. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (0.1% FA), 10% to 50% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 66%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 497.16, found 497.05. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 10.57 (s, 1H), 7.88-7.80 (m, 2H), 7.73 (d, J=8.5 Hz, 1H), 7.64-7.50 (m, 2H), 7.45-7.37 (m, 1H), 7.18 (t, J=8.0 Hz, 1H), 7.12-7.05 (m, 1H), 6.34 (d, J=7.0 Hz, 1H), 5.20 (d, J=7.1 Hz, 1H), 3.51-3.39 (m, 1H), 2.75 (d, J=13.6 Hz, 1H), 1.79 (s, 3H), 1.75 (s, 3H). .sup.19F NMR (376 MHz, DMSO-d.sub.6) ? ?111.02, ?111.03, ?111.08, ?111.09, ?122.66, ?122.71.

Example 72: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0583] ##STR00365##

[0584] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.171 mmol) and 4-bromo-1-[(dimethylphosphoryl)methyl]-2-fluorobenzene (90 mg, 0.342 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (13 mg, 0.017 mmol) and K.sub.3PO.sub.4 (109 mg, 0.513 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (45 mg, 50%) as a white solid. MS ESI calculated for C.sub.27H.sub.23F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 526.14, found 526.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47-8.43 (m, 1H), 7.82 (d, J=8.6 Hz, 1H), 7.69 (s, 1H), 7.55-7.48 (m, 2H), 7.48-7.39 (m, 3H), 7.39-7.34 (m, 1H), 7.30 (d, J=11.3 Hz, 1H), 6.89 (t, J=72.6 Hz, 1H), 6.45 (d, J=7.2 Hz, 1H), 5.21 (d, J=6.7 Hz, 1H), 3.60-3.50 (m, 1H), 3.25 (d, J=15.0 Hz, 2H), 2.92 (d, J=13.4 Hz, 1H), 1.59-1.54 (m, 3H), 1.54-1.49 (m, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?81.04, ?116.56. .sup.31P NMR (162 MHz, Chloroform-d) ? 41.14.

Example 73: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,5-difluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0585] ##STR00366##

[0586] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-methyl-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (100 mg, 0.166 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]-2,5-difluorobenzene (56 mg, 0.199 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added K.sub.3PO.sub.4 (105 mg, 0.498 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (13 mg, 0.017 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 4 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,5-difluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (15 mg, 16%) as a white solid. MS ESI calculated for C.sub.28H.sub.24F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 558.15, found 558.05. .sup.1H NMR (400 MHz, DMSO-d) ? 8.28-8.25 (m, 1H), 7.79-7.43 (m, 5H), 7.43-7.29 (m, 3H), 6.27 (d, J=7.1 Hz, 1H), 5.25 (d, J=7.1 Hz, 1H), 3.60-3.47 (m, 1H), 3.36 (s, 3H), 3.23 (d, J=14.7 Hz, 2H), 2.82 (d, J=13.8 Hz, 1H), 1.45 (s, 3H), 1.42 (s, 3H). .sup.19F NMR (376 MHz, DMSO-d.sub.6) ? ?81.58, ?82.03, ?82.43, ?82.86, ?121.74, ?121.79, ?124.19, ?124.24. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 38.79.

Example 74: (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-methoxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0587] ##STR00367##

[0588] To a stirred solution of (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.101 mmol) and K.sub.2CO.sub.3 (42 mg, 0.303 mmol) in DMF (1 mL) was added CH.sub.3I (17 mg, 0.121 mmol) dropwise at room temperature. The mixture was stirred for 16 h at room temperature. The resulting mixture was concentrated under reduce pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (0.1% FA), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-methoxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (29 mg, 56%) as a light yellow solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 511.17, found 511.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.25-8.18 (m, 1H), 7.87-7.73 (m, 3H), 7.46-7.31 (m, 2H), 7.27-7.20 (m, 1H), 7.16-7.09 (m, 1H), 6.49-6.43 (m, 1H), 5.07 (s, 1H), 4.10 (s, 3H), 3.45 (s, 1H), 2.90 (d, J=12.0 Hz, 1H), 1.86 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?111.71, ?111.73, ?111.77, ?111.78, ?122.22, ?122.27. .sup.31P NMR (162 MHz, Chloroform-d) ? 29.97.

Example 75: (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-ethoxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0589] ##STR00368##

[0590] To a stirred solution of ((7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.101 mmol) and K.sub.2CO.sub.3 (42 mg, 0.303 mmol) in DMF (1 mL) was added iodoethane (19 mg, 0.121 mmol) dropwise at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at room temperature. The resulting mixture was concentrated under reduce pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. This resulted in (7R,14R)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-1-ethoxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (36 mg, 67%) as a white solid. MS ESI calculated for C.sub.28H.sub.23D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 525.19, found 525.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.24-8.17 (m, 1H), 7.90-7.73 (m, 3H), 7.43-7.37 (m, 1H), 7.33 (t, J=8.2 Hz, 1H), 7.28-7.19 (m, 1H), 7.13-7.06 (m, 1H), 6.48 (d, J=7.1 Hz, 1H), 5.01 (d, J=6.9 Hz, 1H), 4.39-4.28 (m, 1H), 4.25-4.13 (m, 1H), 3.50-3.38 (m, 1H), 2.88 (d, J=13.4 Hz, 1H), 1.86 (s, 3H), 1.83 (s, 3H), 1.66 (t, J=6.9 Hz, 3H). .sup.19 NMR (376 MHz, Chloroform-d) ? ?111.82, ?111.84, ?111.88, ?111.89, ?122.36, ?122.41. .sup.31P NMR (162 MHz, Chloroform-A) 30.04.

Example 76: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,3-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0591] ##STR00369##

Preparation 76A: (4-bromo-2,3-difluorophenyl)methanol

[0592] ##STR00370##

[0593] To a stirred solution of 4-bromo-2,3-difluorobenzoic acid (5.00 g, 21.097 mmol) in THF (50 mL) was added borane (74 mL, 73.840 mmol, 1M in THF) dropwise at room temperature. The resulting mixture was stirred for 4 h at 60? C. The reaction was quenched with water at 0? C. The resulting mixture was extracted with EtOAc (3?50 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2MeOH (10/1) to afford (4-bromo-2,3-difluorophenyl)methanol (4.60 g, 98%) as a white solid. MS ESI calculated for C.sub.7H.sub.5BrF.sub.2O [M+H].sup.+, 222.95 224.95, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.35-7.31 (m, 1H), 7.17-7.10 (m, 1H), 4.76 (s, 2H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?130.76, ?130.81, ?140.40, ?140.46.

Preparation 76B: 1-bromo-4-(bromomethyl)-2,3-difluorobenzene

[0594] ##STR00371##

[0595] A solution of (4-bromo-2,3-difluorophenyl)methanol (4.60 g, 21.075 mmol) in HBr in AcOH (10 mL) was stirred for 30 min at 100? C. The mixture was allowed to cool down to room temperature. The mixture was basified to pH 8 with NaOH (1M). The resulting mixture was extracted with EtOAc (3?100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (7/1) to afford 1-bromo-4-(bromomethyl)-2,3-difluorobenzene (5.29 g, 87%) as a colorless liquid. MS ESI calculated for C.sub.7H.sub.4Br.sub.2F.sub.2 [M+H].sup.+, 284.86 286.86 288.86, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.33-7.29 (m, 1H), 7.10-7.04 (m, 1H), 4.47 (s, 2H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?129.14, ?129.19, ?137.16, ?137.22.

Preparation 76C: 1-bromo-4-[(dimethylphosphoryl)methyl]-2,3-difluorobenzene

[0596] ##STR00372##

[0597] To a stirred solution of (methylphosphonoyl)methane (1.50 g, 19.237 mmol) in THF (50 mL) was added NaHMDS (19 mL, 19.237 mmol, 1 M in THF) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at room temperature under nitrogen atmosphere. To the above mixture was added 1-bromo-4-(bromomethyl)-2,3-difluorobenzene (5.00 g, 17.488 mmol) at 0? C. The resulting mixture was stirred for additional 16 h at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The resulting mixture was extracted with EtOAc (3?100 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 70% gradient in 20 min; detector, 254 nm to afford 1-bromo-4-[(dimethylphosphoryl)methyl]-2,3-difluorobenzene (340 mg, 6%) as a white solid. MS ESI calculated for C.sub.9H.sub.10BrF.sub.2OP [M+H].sup.+, 282.96 284.96, found 282.85 284.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.16-7.05 (m, 2H), 3.27-3.18 (m, 2H), 1.54 (s, 3H), 1.51 (s, 3H).

Example 76: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,3-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0598] ##STR00373##

[0599] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]-2,3-difluorobenzene (53 mg, 0.186 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,3-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (38 mg, 55%) as a white solid. MS ESI calculated for C.sub.28H.sub.21D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 561.17, found 561.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.46 (m, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.68 (s, 1H), 7.42 (t, J=8.2 Hz, 2H), 7.32 (d, J=8.1 Hz, 1H), 7.20 (d, J=3.8 Hz, 2H), 7.03-6.63 (m, 1H), 6.29 (d, J=7.0 Hz, 1H), 5.01 (d, J=6.8 Hz, 1H), 3.53-3.42 (m, 1H), 3.27 (d, J=14.7 Hz, 2H), 2.89 (d, J=13.4 Hz, 1H), 1.58 (s, 3H), 1.55 (s, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.01, ?80.46, ?81.40, ?81.85, ?141.15, ?141.21, ?143.04, ?143.09. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.70.

Example 77. (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0600] ##STR00374##

[0601] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-methyl-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.166 mmol) and 5-bromo-2-[(dimethylphosphoryl)methyl]-1,3-difluorobenzene (94 mg, 0.332 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (14 mg, 0.017 mmol) and K.sub.3PO.sub.4 (106 mg, 0.498 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 70% gradient in 20 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (28 mg, 30%) as a white solid. MS ESI calculated for C.sub.28H.sub.24F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 558.15, found 558.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.47 (m, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.68 (s, 1H), 7.49-7.40 (m, 2H), 7.33 (d, J=8.1 Hz, 1H), 7.18 (d, J=8.4 Hz, 2H), 6.88 (t, J=72.8 Hz, 1H), 6.31 (d, J=6.6 Hz, 1H), 5.05 (d, J=6.6 Hz, 1H), 3.55 (s, 3H), 3.53-3.46 (m, 1H), 3.31 (d, J=16.1 Hz, 2H), 2.91 (d, J=13.4 Hz, 1H), 1.57 (s, 3H), 1.54 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.92, ?112.41. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.10.

Example 78: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0602] ##STR00375##

[0603] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.159 mmol) and 4-bromo-1-[(dimethylphosphoryl)methyl]-2-fluorobenzene (84 mg, 0.318 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (13 mg, 0.016 mmol) and K.sub.3PO.sub.4 (101 mg, 0.477 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 70% gradient in 20 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (35 mg, 38%) as a white solid. MS ESI calculated for C.sub.28H.sub.21D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 561.17, found 561.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.47 (m, 1H), 7.52-7.47 (m, 2H), 7.47-7.39 (m, 2H), 7.36-7.28 (m, 3H), 6.83 (t, J=72.7 Hz, 1H), 6.26 (d, J=7.1 Hz, 1H), 5.00 (d, J=7.0 Hz, 1H), 3.54-3.43 (m, 1H), 3.26 (d, J=15.1 Hz, 2H), 2.89 (d, J=13.5 Hz, 1H), 1.55 (s, 3H), 1.52 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.54, ?80.99, ?81.05, ?81.49, ?116.93, ?122.18. .sup.31P NMR (162 MHz, Chloroform-d) ? 41.22.

Example 79: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0604] ##STR00376##

[0605] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-methyl-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.166 mmol) and 4-bromo-1-[(dimethylphosphoryl)methyl]-2-fluorobenzene (88 mg, 0.332 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) was added K.sub.3PO.sub.4 (106 mg, 0.498 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (14 mg, 0.017 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: XBridge Shield RP18 OBD Column 30*150 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 16% B to 36% B in 10 min; Wave Length: 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (16 mg, 17%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 540.16, found 540.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.46 (m, 1H), 7.78 (d, J=8.5 Hz, 1H), 7.69 (d, J=1.7 Hz, 1H), 7.51-7.28 (m, 6H), 6.77 (d, J=72.8 Hz, 1H), 6.30 (d, J=7.1 Hz, 1H), 5.03 (d, J=7.0 Hz, 1H), 3.54 (s, 3H), 3.53-3.43 (m, 1H), 3.25 (d, J=15.1 Hz, 2H), 2.90 (d, J=13.5 Hz, 1H), 1.55 (s, 3H), 1.51 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.36, ?80.81, ?80.89, ?80.34, ?116.73. .sup.31P NMR (162 MHz, Chloroform-d) ? 41.40.

Example 80: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2-fluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0606] ##STR00377##

[0607] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-methyl-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.166 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]-2-fluorobenzene (88 mg, 0.332 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) was added K.sub.3PO.sub.4 (106 mg, 0.498 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (13 mg, 0.017 mmol) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by Prep-HPLC with the following conditions: Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.1% NH.sub.3H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 18% B to 33% B in 10 min; Wave Length: 254/220 nm; RT1 (min); 11.92 to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3-fluorophenyl)-6-methyl-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (22 mg, 24%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 540.16, found 540.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.46 (m, 1H), 7.78 (d, J=8.5 Hz, 1H), 7.69 (s, 1H), 7.45-7.38 (m, 3H), 7.34-7.30 (m, 1H), 7.15-7.05 (m, 2H), 6.82 (t, J=73.6 Hz, 1H), 6.29 (d, J=7.1 Hz, 1H), 5.03-4.97 (m, 1H), 3.53 (s, 3H), 3.51-3.41 (m, 1H), 3.19 (d, J=14.8 Hz, 2H), 2.89 (d, J=13.5 Hz, 1H), 1.54 (s, 3H), 1.51 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.88, ?80.32, ?81.40, ?81.85, ?117.54. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.20.

Example 81: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0608] ##STR00378##

[0609] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.150 mmol) and 5-bromo-2-[(dimethylphosphoryl)methyl]-1,3-difluorobenzene (64 mg, 0.225 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) was added K.sub.3PO.sub.4 (96 mg, 0.450 mmol) and Pd(dppf)Cl.sub.2CH.sub.2Cl.sub.2 (12 mg, 0.015 mmol) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.1% NHH.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 17% B to 33% B in 10 min; Wave Length: 254/220 nm; RT1 (min); 11.68 to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-3,5-difluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (28 mg, 33%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.46-8.42 (m, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.64 (d, J=1.7 Hz, 1H), 7.49-7.35 (m, 4H), 7.17 (d, J=8.4 Hz, 2H), 6.89 (t, J=72.7 Hz, 1H), 6.39 (d, J=7.2 Hz, 1H), 5.03-4.96 (m, 1H), 3.55-3.45 (m, 1H), 3.31 (d, J=16.1 Hz, 2H), 2.89 (d, J=13.3 Hz, 1H), 1.58 (s, 3H), 1.54 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?81.01, ?112.49. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.20.

Example 82: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,5-difluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0610] ##STR00379##

[0611] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.128 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]-2,5-difluorobenzene (73 mg, 0.256 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (82 mg, 0.384 mmol and Pd(dppf)Cl.sub.2CH.sub.2Cl.sub.2 (10 mg, 0.013 mmol) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: XBridge Shield RP18 OBD Column 30*150 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 13% B to 33% B in 12 min; Wave Length: 254 nm; RT1 (min); 13.3 to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2,5-difluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (14 mg, 19%) as a white solid. MS ESI calculated for C.sub.27H.sub.22F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 544.13, found 544.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.48-8.42 (m, 1H), 7.84 (d, J=8.6 Hz, 1H), 7.73 (t, J=1.5 Hz, 1H), 7.53-7.37 (m, 4H), 7.25-7.14 (m, 2H), 6.86 (t, J=73.0 Hz, 1H), 6.45 (d, J=7.3 Hz, 1H), 5.25 (t, J=6.7 Hz, 1H), 3.61-3.50 (m, 1H), 3.22 (d, J=14.5 Hz, 2H), 2.93 (d, J=13.4 Hz, 1H), 1.58 (d, J=2.9 Hz, 3H), 1.55 (d, J=2.9 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.39, ?80.84, ?81.48, ?81.93, ?122.46, ?122.47, ?122.51, ?122.51, ?122.79, ?122.83. .sup.31P NMR (162 MHz, Chloroform-d) 40.36.

Example 83: dimethyl (4-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)benzyl)phosphonate

[0612] ##STR00380##

[0613] Preparation 83A: (7R,14R)-1-(difluoromethoxy)-11-(4-(hydroxymethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

##STR00381##

[0614] Into a 8 mL vial were added (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (100 mg, 0.255 mmol), [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol (71 mg, 0.306 mmol), K.sub.3PO.sub.4 (162 mg, 0.765 mmol), SPhos (10 mg, 0.026 mmol), SPhos Pd G3 (19 mg, 0.026 mmol), 1,4-dioxane (2.5 mL) and H.sub.2O (0.5 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred for overnight at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford (7R,14R)-1-(difluoromethoxy)-11-(hydroxymethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,4-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (95 mg, 80%) as a pink solid. MS ESI calculated for C.sub.26H.sub.18D.sub.3F.sub.2N.sub.3O.sub.3 [M+H].sup.+, 465.17, found 465.30. .sup.1H NMR (400 MHz, Chloroform-d) ? ?8.51-8.46 (m, 1H), 7.77 (d, J=8.5 Hz, 1H), 7.72-7.67 (m, 1H), 7.60-7.54 (m, 2H), 7.53-7.38 (m, 4H), 7.35-7.27 (m, 1H), 6.83 (t, J=72.9 Hz, 12), 6.30 (d, J=7.2 Hz, 1H), 5.04 (d, J=7.1 Hz, 1), 4.75 (s, 2H), 3.53-3.44 (m, 1H), 2.89 (d, J=13.6 Hz, 1H).

Preparation 83B: (7R,14R)-11-(4-(chloromethyl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0615] ##STR00382##

[0616] To a solution of (7R,14R)-1-(difluoromethoxy)-11-(4-(hydroxymethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (85 mg, 0.183 mmol) in Toluene (2 mL) was added thionyl chloride (1 mL) dropwise at 0? C. The resulting mixture was stirred for 2 h at 60? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum to afford (7R,14R)-11-(4-(chloromethyl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (90 mg) as a yellow solid. The crude product was used in the next step without further purification. MS ESI calculated for C.sub.26H.sub.17D.sub.3ClF.sub.2N.sub.3O.sub.2 [M+H].sup.+, 483.14, found 483.30.

Example 83: dimethyl (4-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)benzyl)phosphonate

[0617] ##STR00383##

[0618] Into a 40 mL vial were added (7R,14R)-11-(4-(chloromethyl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (90 mg, 0.186 mmol) and trimethyl phosphite (5 mL) at room temperature. The resulting mixture was stirred overnight at 115? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The crude product was purified by Prep-HPLC with the following conditions (Column: Xselect CSH C.sub.18 OBD Column 30*150 mm 5 ?m; Mobile Phase A: Water (0.1% FA), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 20% B to 40% B in 8 min; Wave Length: 254 nm/220 nm) to afford dimethyl (4-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)benzyl)phosphonate (18 mg, 17%) as a white solid. MS ESI calculated for C.sub.28H.sub.23D.sub.3F.sub.2N.sub.3O.sub.5P [M+H].sup.+, 557.18, found 557.35. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.46 (m, 1H), 7.75 (d, J=8.5 Hz, 1H), 7.71-7.66 (m, 1H), 7.56 (d, J=7.9 Hz, 2H), 7.51-7.46 (m, 1H), 7.45-7.35 (m, 3H), 7.31 (d, J=8.2 Hz, 1H), 6.84 (t, J=72.9 Hz, 1H), 6.28 (d, J=7.0 Hz, 1H), 4.97 (d, J=6.9 Hz, 1H), 3.73 (s, 3H), 3.70 (s, 3H), 3.50-3.41 (m, 1H), 3.22 (d, J=21.7 Hz, 2H), 2.87 (d, J=13.4 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.16, ?80.61, ?80.91, ?81.36. .sup.31P NMR (162 MHz, Chloroform-d) ? 28.83.

Example 84: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)(hydroxy)methyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0619] ##STR00384##

Preparation 84A: (4-bromophenyl)(dimethylphosphoryl)methanol

[0620] ##STR00385##

[0621] To a stirred mixture of 4-bromobenzaldehyde (20.00 g, 108.096 mmol) and (methylphosphonoyl)methane (12.66 g, 162.144 mmol) in THF (200 mL) was added TEA (30 mL, 216.192 mmol) at room temperature. The resulting mixture was stirred for 4 h at 55? C. The resulting mixture was concentrated under vacuum. The residue was purified by trituration with Et.sub.2O/EtOH (100/1) (3?100 mL). The precipitated solids were collected by filtration. The resulting mixture was concentrated under reduced pressure. This resulted in (4-bromophenyl)(dimethylphosphoryl)methanol (20.10 g, 70%) as a white solid. MS ESI calculated for C.sub.9H.sub.12BrO.sub.2P [M+H].sup.+, 262.98 264.98, found 263.05 265.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.48-7.46 (m, 2H), 7.27-7.25 (m, 2H), 5.29 (s, 1H), 4.94-4.91 (m, 1H), 1.47-1.38 (m, 3H), 1.31-1.27 (m, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 48.53.

Example 84: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)(hydroxy)methyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0622] ##STR00386##

[0623] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol) and (4-bromophenyl)(dimethylphosphoryl)methanol (45 mg, 0.174 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (92 mg, 0.435 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (12 mg, 0.014 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)(hydroxy)methyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (31 mg, 39%) as a white solid. MS ESI calculated for C.sub.28H.sub.23D.sub.3F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 541.18, found 541.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.46 (m, 1H), 7.80-7.63 (m, 2H), 7.61-7.56 (m, 2H), 7.53-7.45 (m, 3H), 7.44-7.37 (m, 1H), 7.33-7.27 (m, 1H), 6.83 (t, J=72.8 Hz, 1H), 6.28-6.16 (m, 1H), 5.04 (d, J=6.9 Hz, 1H), 5.01-4.95 (m, J H), 3.92 (s, J H), 3.53-3.42 (m, 1H), 2.87 (d, J=13.4 Hz, 1H), 1.54-1.40 (m, 6H). .sup.19F NMR (376 MHz, DMSO-d.sub.6) ? ?81.62, ?81.64, ?82.07, ?82.09, ?82.20, ?82.23, ?82.65, ?82.67. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.95.

Example 85 and 86: (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0624] ##STR00387## ##STR00388##

Preparation 85A: 1-bromo-4-(1-bromoethyl)benzene

[0625] ##STR00389##

[0626] A mixture of 1-(4-bromophenyl)ethanol (5.00 g, 24.868 mmol) and HBr (25 mL) was stirred for 15 min at 100? C. The mixture was basified to pH 8 with 1M NaOH(aq). The aqueous layer was extracted with EtOAc (3?100 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE to afford 1-bromo-4-(1-bromoethyl)benzene (5.10 g, 76%) as a yellow oil. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.49-7.44 (m, 2H), 7.33-7.29 (m, 2H), 5.15 (q, J=6.9 Hz, 1H), 2.01 (d, J=6.9 Hz, 3H).

Preparation 85B: 1-bromo-4-[1-(dimethylphosphoryl)ethyl]benzene

[0627] ##STR00390##

[0628] To a stirred solution of (methylphosphonoyl)methane (2.96 g, 37.884 mmol) in THF (50 mL) was added NaHMDS (18.2 mL, 164.509 mmol, 1M in THF) at 0? C. under nitrogen atmosphere. The mixture was stirred for 15 min at 0? C. To the above mixture was added 1-bromo-4-(1-bromoethyl)benzene (5.00 g, 18.942 mmol) at 0? C. The resulting mixture was stirred for additional 16 h at 20? C. The reaction was quenched by the addition of water (2 mL) at room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 1-bromo-4-[1-(dimethylphosphoryl)ethyl]benzene (1.00 g, 20%) as a white solid. MS ESI calculated for C.sub.10H.sub.14BrOP [M+H].sup.+, 261.00 263.00, found 261.05 263.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.51-7.44 (m, 2H), 7.21-7.16 (m, 2H), 3.06-2.97 (m, 1H), 1.65-1.57 (m, 3H), 1.49-1.44 (m, 3H), 1.34-1.29 (m, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 45.95.

Preparation 85C: (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0629] ##STR00391##

[0630] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (97 mg, 0.372 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added K.sub.3PO.sub.4 (197 mg, 0.930 mmol) and Pd(dppf)Cl.sub.2CH.sub.2Cl.sub.2 (25 mg, 0.031 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (100 mg, 59%). MS ESI calculated for C.sub.29H.sub.25D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 539.20, found 539.20.

Example 85 and 86: (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0631] ##STR00392##

[0632] The (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (165 mg) was resolved by SFC with the following conditions: Column: CHIRALPAK IH 3*25 cm, 5 ?m; Mobile Phase A: CO.sub.2, Mobile Phase B: MeOH (20 mM NH.sub.3); Flow rate: 100 mL/min; Gradient: isocratic 30% B; Wave Length: 276/208 nm; RT1 (min); 6.75; RT2 (min); 8.32. The first peak afforded 32 mg (19%) as a white solid. MS ESI calculated for C.sub.29H.sub.25D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 539.20, found 539.30. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.32-8.24 (m, 1H), 7.87-7.66 (m, 3H), 7.62-7.56 (m, 2H), 7.54-7.47 (m, 3H), 7.42-7.37 (m, 2H), 6.29 (d, J=7.1 Hz, 1H), 5.23 (d, J=7.1 Hz, 1H), 3.58-3.47 (m, 1H), 3.23-3.11 (m, 1H), 2.82 (d, J=13.8 Hz, 1H), 1.53-1.44 (m, 3H), 1.43-1.37 (m, 3H), 1.25-1.16 (m, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.62, ?82.07, ?82.15, ?82.60. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.32.

[0633] The second peak afforded 33 mg (20%) as a white solid. MS ESI calculated for C.sub.29H.sub.25D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 539.20, found 539.35. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.30-8.25 (m, 1H), 7.87-7.65 (m, 3H), 7.59 (d, J=8.2 Hz, 2H), 7.53-7.47 (m, 3H), 7.41-7.36 (m, 2H), 6.29 (d, J=7.1 Hz, 1H), 5.23 (d, J=7.1 Hz, 1H), 3.58-3.48 (m, 1H), 3.24-3.13 (m, 1H), 2.82 (d, J=13.7 Hz, 1H), 1.53-1.45 (m, 3H), 1.42-1.37 (m, 3H), 1.24-1.17 (m, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.60, ?82.05, ?82.16, ?82.61. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.33.

Example 87: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-4-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0634] ##STR00393##

[0635] Into a 8 mL vial were added (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol), 5-bromo-2-(dimethylphosphoryl)-4-methylpyridine (47 mg, 0.189 mmol), Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (12 mg, 0.014 mmol), K.sub.3PO.sub.4 (92 mg, 0.435 mmol), H.sub.2O (0.2 mL) and 1,4-dioxane (1 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (7/1) followed by Prep-HPLC with the following conditions (Column: XBridge Shield RP18 OBD Column 30*150 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.1% NH.sub.3.Math.H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 33% B to 53% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 10.5) to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-4-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (28 mg, 37%) as white solid. MS ESI calculated for C.sub.27H.sub.22D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 526.18, found 526.35. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.55 (s, 1H), 8.31-8.27 (m, 1H), 7.92 (d, J=5.6 Hz, 1H), 7.79-7.67 (m, 1H), 7.57-7.33 (m, 4H), 7.27 (m, 1H), 6.26 (d, J=7.1 Hz, 1H), 5.26 (d, J=7.1 Hz, 1H), 3.53 (m, 1H), 2.83 (d, J=13.9 Hz, 1H), 2.32 (s, 3H), 1.71 (s, 3H), 1.68 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.49, ?81.94, ?82.01, ?82.45. .sup.31P NMR (162 MHz, DMSO-d) ? 33.87.

Example 88: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0636] ##STR00394##

Preparation 88A: 1-bromo-4-(dimethylphosphoryl)-5-fluoro-2-methylbenzene

[0637] ##STR00395##

[0638] To a stirred mixture of 1-bromo-5-fluoro-4-iodo-2-methylbenzene (2.00 g, 6.351 mmol) and (methylphosphonoyl)methane (545 mg, 6.986 mmol) in 1,4-dioxane (20 mL) were added K.sub.3PO.sub.4 (4.01 g, 19.053 mmol), Xantphos (367 mg, 0.635 mmol) and Pd.sub.2(dba).sub.3 (291 mg, 0.318 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (20:1) to afford 1-bromo-4-(dimethylphosphoryl)-5-fluoro-2-methylbenzene (1.40 g, 83%) as a yellow solid. MS ESI calculated for C.sub.9H.sub.11BrFOP [M+H].sup.+, 264.97 266.97, found 264.90 266.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.86-7.77 (m, 1H), 7.37-7.31 (m, 1H), 2.42 (s, 3H), 1.80 (s, 3H), 1.77 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 30.84.

Preparation 88B: 2-[4-(dimethylphosphoryl)-5-fluoro-2-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

[0639] ##STR00396##

[0640] To a stirred mixture of 1-bromo-4-(dimethylphosphoryl)-5-fluoro-2-methylbenzene (1.60 g, 6.036 mmol) and BPD (1.84 g, 7.243 mmol) in 1,4-dioxane (24 mL) were added KOAc (1.18 g, 12.072 mmol), PCy.sub.3 (169 mg, 0.604 mmol) and Pd(OAc).sub.2 (136 mg, 0.604 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 4 h at 80? C. under nitrogen atmosphere. The residue was basified to pH 8 with 10% NaOH (aq). The resulting mixture was washed with 3?20 mL of DCM. The residue was acidified to pH 4 with 1M HCl (aq). The aqueous layer was extracted with EtOAc (3?40 mL). The resulting mixture was concentrated under reduced pressure. This resulted in 2-[4-(dimethylphosphoryl)-5-fluoro-2-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.70 g, 90%) as a colorless oil. MS ESI calculated for C.sub.15H.sub.23BF O.sub.3P [M+H].sup.+, 313.15, found 313.00.

Example 88: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0641] ##STR00397##

[0642] To a stirred mixture of (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (600 mg, 1.527 mmol) and 2-[4-(dimethylphosphoryl)-5-fluoro-2-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (953 mg, 3.054 mmol) in 1,4-dioxane (12 mL) and H.sub.2O (2.4 mL) were added K.sub.3PO.sub.4 (973 mg, 4.581 mmol), SPhos (63 mg, 0.153 mmol) and SPhos Pd G3 (119 mg, 0.153 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 4 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (548 mg, 66%) as a white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 543.18, found 543.15. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.34-8.26 (m, 1H), 7.74-7.70 (m, 1H), 7.69-7.65 (m, 1H), 7.56-7.35 (m, 4H), 7.25-7.20 (m, 1H), 7.20-7.14 (m, 1H), 6.25 (d, J=7.1 Hz, 1H), 5.25 (d, J=7.1 Hz, 1H), 3.60-3.48 (m, 1H), 2.83 (d, J=13.8 Hz, 1H), 2.23 (s, 3H), 1.76 (s, 3H), 1.72 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.94, ?110.80. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 28.26.

Example 89: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-4-methylpyridin-3-yl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0643] ##STR00398##

[0644] Into a 8 mL vial were added (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.159 mmol), 5-bromo-2-(dimethylphosphoryl)-4-methylpyridine (51 mg, 0.207 mmol), Pd(dppf)Cl.sub.2 (13 mg, 0.016 mmol), K.sub.3PO.sub.4 (101 mg, 0.477 mmol), H.sub.2O (0.2 mL) and 1,4-dioxane (1 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (7/1) followed by Prep-HPLC with the following conditions (Column: XBridge Shield RP18 OBD Column 30*150 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 35% B to 55% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 10.7) to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-4-methylpyridin-3-yl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (19 mg, 22%) as white solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 544.17, found 544.30. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.56 (s, 1H), 8.33-8.25 (m, 1H), 7.95 (d, J=5.7 Hz, 1H), 7.73-7.61 (m, 1H), 7.55-7.30 (m, 4H), 6.26 (d, J=7.1 Hz, 1H), 5.27 (d, J=7.2 Hz, 1H), 3.58-3.48 (m, 1H), 2.83 (d, J=13.8 Hz, 1H), 2.22 (s, 3H), 1.72 (s, 3H), 1.69 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.58, ?82.03, ?82.17, ?82.62, ?121.56. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 34.03.

Example 90: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0645] ##STR00399##

Preparation 90A: 1-bromo-4-(dimethylphosphoryl)-3-fluoro-2-methylbenzene

[0646] ##STR00400##

[0647] Into a 40 mL vial were added 1-bromo-3-fluoro-4-iodo-2-methylbenzene (500 mg, 1.588 mmol), (methylphosphonoyl)methane (136 mg, 1.747 mmol), Pd.sub.2(dba).sub.3 (36 mg, 0.040 mmol), XantPhos (45 mg, 0.079 mmol), K.sub.3PO.sub.4 (404 mg, 1.906 mmol) and 1,4-dioxane (8 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred for 1 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8/1) to afford 1-bromo-4-(dimethylphosphoryl)-3-fluoro-2-methylbenzene (320 mg, 76%) as reddish brown oil. MS ESI calculated for C.sub.9H.sub.11BrFOP [M+H].sup.+, 264.97 266.97, found 264.95 266.95. .sup.1H NMR (400 MHz, Methanol-d.sub.4) ? 7.69-7.47 (m, 2H), 2.39 (d, J=2.5 Hz, 3H), 1.85 (d, J=1.3 Hz, 3H), 1.81 (d, J=1.3 Hz, 3H).

Example 90: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0648] ##STR00401##

[0649] Into a 8 mL vial were added (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol), 1-bromo-4-(dimethylphosphoryl)-3-fluoro-2-methylbenzene (57 mg, 0.217 mmol), Pd(dppf)Cl.sub.2 (11 mg, 0.014 mmol), K.sub.3PO.sub.4 (92 mg, 0.435 mmol), 1,4-dioxane (2 mL) and H.sub.2O (0.5 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred for 1 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8/1) followed by Prep-HPLC with the following conditions (Column: Spherical CSH C18 OBD Column 20-35 um 100 A, 40 g; Mobile Phase A: Water (0.1% FA), Mobile Phase B: ACN; Flow rate: 40 mL/min; Gradient: 25% B to 50% B in 15 min; Wave Length: 254 nm/220 nm; RT1 (min); 5.4) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (41 mg, 53%) as white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 543.18 found 543.30. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.56-8.48 (m, 1H), 7.88-7.79 (m, 2H), 7.53-7.43 (m, 2H), 7.36-7.28 (m, 2H), 7.20 (d, J=7.6 Hz, 1H), 6.78 (t, J=72.6 Hz, 1H), 6.38-6.31 (m, 1H), 5.29-5.19 (m, 1H), 3.64-3.48 (m, 1H), 2.96 (d, J=11.1 Hz, 1H), 2.17 (d, J=2.6 Hz, 3H), 1.88 (s, 3H), 1.84 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.78, ?107.55. .sup.31P NMR (162 MHz, Chloroform-d) ? 31.17.

Example 91: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0650] ##STR00402##

Preparation 91A: 3-bromo-6-(dimethylphosphoryl)-2-methylpyridine

[0651] ##STR00403##

[0652] Into a 40 mL vial were added 3-bromo-6-iodo-2-methylpyridine (1.00 g, 3.357 mmol), (methylphosphonoyl)methane (288 mg, 3.693 mmol), Pd.sub.2(dba).sub.3 (76 mg, 0.084 mmol), XantPhos (97 mg, 0.168 mmol), K.sub.3PO.sub.4 (854 mg, 4.028 mmol) and 1,4-dioxane (15 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred for 1 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8:1) to afford 3-bromo-6-(dimethylphosphoryl)-2-methylpyridine (780 mg, 93%) as yellow solid. MS ESI calculated for C.sub.8H.sub.11BrNOP [M+H].sup.+, 247.98 249.98 found 248.00, 250.00. .sup.1H NMR (400 MHz, Methanol-d.sub.4) ? 8.14 (m, 1H), 7.71 (m, 1H), 2.70 (s, 3H), 1.80 (s, 3H), 1.77 (s, 3H).

Example 91: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0653] ##STR00404##

[0654] Into a 8 mL vial were added (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol), 3-bromo-6-(dimethylphosphoryl)-2-methylpyridine (54 mg, 0.217 mmol), Pd(dppf)Cl.sub.2 (11 mg, 0.014 mmol), K.sub.3PO.sub.4 (92 mg, 0.435 mmol), 1,4-dioxane (2 mL) and H.sub.2O (0.5 mL) at room temperature. The mixture was purged with nitrogen for 3 min and then was stirred for 1 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 um; Mobile Phase A: Water (0.1% FA), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 25% B to 50% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 12.43) to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (39 mg, 51%) as white solid. MS ESI calculated for C.sub.27H.sub.22D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 526.18, found 526.30. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.48 (m, 1H), 8.03-7.98 (m, 1H), 7.80 (d, J=8.4 Hz, 1H), 7.68-7.63 (m, 1H), 7.48-7.40 (m, 2H), 7.32 (d, J=8.2 Hz, 1H), 7.25-7.21 (m, 1H), 6.77 (t, J=72.8 Hz, 1H), 6.27 (d, J=7.2 Hz, 1H), 5.04 (d, J=7.1 Hz, 1H), 3.56-3.44 (m, 1H), 2.91 (d, J=13.6 Hz, 1H), 2.52 (s, 3H), 1.85 (s, 3H), 1.82 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.71. .sup.31P NMR (162 MHz, Chloroform-d) ? 36.54.

Example 92: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-fluoropyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0655] ##STR00405##

Preparation 92A: 3-bromo-6-(dimethylphosphoryl)-2-fluoropyridine

[0656] ##STR00406##

[0657] To a stirred solution of 3-bromo-2-fluoro-6-iodopyridine (1.00 g, 3.313 mmol) and (methylphosphonoyl)methane (310 mg, 3.976 mmol) in 1,4-dioxane (10 mL) were added Pd.sub.2(dba).sub.3 (76 mg, 0.083 mmol), XantPhos (96 mg, 0.166 mmol) and K.sub.3PO.sub.4 (843 mg, 3.976 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 3-bromo-6-(dimethylphosphoryl)-2-fluoropyridine (428 mg, 51%) as a yellow solid. MS ESI calculated for C.sub.7H.sub.8BrFNOP [M+H].sup.+, 251.95 253.95, found 252.00 254.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.17-8.13 (m, 1H), 7.93-7.87 (m, 1H), 1.80 (s, 3H), 1.76 (s, 3H).

Example 92: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-fluoropyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0658] ##STR00407##

[0659] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 3-bromo-6-(dimethylphosphoryl)-2-fluoropyridine (47 mg, 0.186 mmol) in 1,4-dioxane (1 mL, 0.011 mmol) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 1 h at 80? C. under hydrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-fluoropyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (41 mg, 62%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 530.16, found 530.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 8.11 (t, J=5.5 Hz, 1H), 8.08-7.99 (m, 1H), 7.85 (d, J=8.5 Hz, 1H), 7.80 (s, 1H), 7.51 (d, J=8.6 Hz, 1H), 7.45 (t, J=8.2 Hz, 1H), 7.32 (d, J=8.2 Hz, 1H), 6.84 (t, J=72.7 Hz, 1H), 6.34 (d, J=6.6 Hz, 1H), 5.10 (d, J=6.5 Hz, 1H), 3.60-3.46 (m, 1H), 2.93 (d, J=13.4 Hz, 1H), 1.84 (s, 3H), 1.80 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?69.77, ?80.22, ?80.67, ?81.00, ?81.44. .sup.31P NMR (162 MHz, Chloroform-d) ? 35.74.

Example 93: (7R,14R)-11-(4-chloro-6-(dimethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0660] ##STR00408##

Preparation 93A: 5-bromo-4-chloro-2-(dimethylphosphoryl)pyridine

[0661] ##STR00409##

[0662] To a stirred solution of 2,5-dibromo-4-chloropyridine (1.00 g, 3.685 mmol) and (methylphosphonoyl)methane (345 mg, 4.422 mmol) in 1,4-dioxane (10 mL) were added Pd.sub.2(dba).sub.3 (84 mg, 0.092 mmol), XantPhos (106 mg, 0.184 mmol) and K.sub.3PO.sub.4 (938 mg, 4.422 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 5-bromo-4-chloro-2-(dimethylphosphoryl)pyridine (240 mg, 24%) as an orange solid. MS ESI calculated for C.sub.7H.sub.8BrClNOP [M+H].sup.+, 267.92 269.92, found 267.80 269.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.83 (s, 1H), 8.21 (d, J=5.3 Hz, 1H), 1.79 (s, 3H), 1.76 (s, 3H).

Example 93. (7R,14R)-11-(4-chloro-6-(dimethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0663] ##STR00410##

[0664] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 5-bromo-4-chloro-2-(dimethylphosphoryl)pyridine (49 mg, 0.186 mmol) in 1,4-dioxane (1 mL, 0.011 mmol) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 1 h at 80? C. under hydrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-11-(4-chloro-6-(dimethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (32 mg, 46%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3ClF.sub.2N.sub.4O.sub.3P [M+H].sup.+, 546.13, found 546.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.63 (s, 1H), 8.51 (d, J=8.2 Hz, 1H), 8.25 (d, J=5.7 Hz, 1H), 7.86 (d, J=8.4 Hz, 1H), 7.66 (s, 1H), 7.44 (t, J=8.2 Hz, 1H), 7.39-7.30 (m, 2H), 6.79 (t, J=72.7 Hz, 1H), 6.31 (d, J=7.1 Hz, JH), 5.08 (d, J=7.0 Hz, 1H), 3.65-3.44 (m, 1H), 2.92 (d, J=13.5 Hz, 1H), 1.85 (s, 3H), 1.81 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.17, ?80.61, ?80.84, ?81.28. .sup.31P NMR (162 MHz, Chloroform-d) ? 36.24.

Example 94: (7R,14R)-11-(2-chloro-6-(dimethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0665] ##STR00411##

Preparation 94A: 3-bromo-2-chloro-6-(dimethylphosphoryl)pyridine

[0666] ##STR00412##

[0667] To a stirred solution of 3,6-dibromo-2-chloropyridine (1.00 g, 3.685 mmol) and (methylphosphonoyl)methane (345 mg, 4.422 mmol) in 1,4-dioxane (10 mL) were added Pd.sub.2(dba); (84 mg, 0.092 mmol), XantPhos (107 mg, 0.184 mmol) and K.sub.3PO.sub.4 (938 mg, 4.422 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 3-bromo-2-chloro-6-(dimethylphosphoryl)pyridine (950 mg, 96%) as an orange solid. MS ESI calculated for C.sub.7H.sub.8BrClNOP [M+H].sup.+, 267.92 269.92, found 267.85 269.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.12-8.09 (m, 1H), 7.93-7.90 (m, 1H), 1.80 (s, 3H), 1.76 (s, 3H).

Example 94: (7R,14R)-11-(2-chloro-6-(dimethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0668] ##STR00413##

[0669] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 3-bromo-2-chloro-6-(dimethylphosphoryl)pyridine (49 mg, 0.186 mmol) in 1,4-dioxane (1 mL, 0.011 mmol) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 1 h at 80? C. under hydrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-11-(2-chloro-6-(dimethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (31 mg, 45%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3ClF.sub.2N.sub.4O.sub.3P [M+H].sup.+, 546.13, found 546.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.48 (m, 1H), 8.16-8.08 (m, 1H), 7.86-7.77 (m, 2H), 7.64 (s, 1H), 7.44 (t, J=8.2 Hz, 1H), 7.40-7.34 (m, 1H), 7.32 (d, J=8.1 Hz, 1H), 6.80 (t, J=72.7 Hz, 1H), 6.30 (d, J=7.2 Hz, JH), 5.07 (d, J=7.0 Hz, 1H), 3.55-3.47 (m, 11H), 2.92 (d, J=13.6 Hz, 1H), 1.86 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.27, ?80.72, ?80.80, ?81.25. .sup.31P NMR (162 MHz, Chloroform-d) ? 36.21.

Example 95: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)difluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0670] ##STR00414##

Preparation 95A: 1-bromo-4-[(dimethylphosphoryl)difluoromethyl]benzene

[0671] ##STR00415##

[0672] A mixture of (methylphosphonoyl)methane (109 mg, 1.400 mmol) and NaHMDS (1.0 mL, 1.050 mmol, 1 M in THF) in THF (4 mL) was stirred for 30 min at 0? C. under nitrogen atmosphere. To the above mixture was added 1-bromo-4-(bromodifluoromethyl)benzene (200 mg, 0.700 mmol) at 0? C. The resulting mixture was stirred for additional 16 h at 20? C. The reaction was quenched with water at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 1-bromo-4-[(dimethylphosphoryl)difluoromethyl]benzene (47 mg, 24%) as a yellow oil. MS ESI calculated for C.sub.9H.sub.10BrF.sub.20P [M+H].sup.+, 282.96 284.96, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.64 (d, J=8.2 Hz, 2H), 7.49 (d, J=8.2 Hz, 2H), 1.63 (s, 3H), 1.60 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?111.51, ?111.77. .sup.31P NMR (162 MHz, Chloroform-d) ? 43.82, 43.21, 42.62.

Example 95: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)difluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0673] ##STR00416##

[0674] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 1-bromo-4-[(dimethylphosphoryl)difluoromethyl]benzene (44 mg, 0.124 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)difluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (21 mg, 31%) as a white solid. MS ESI calculated for C.sub.28H.sub.21D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 561.17, found 561.15. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.31-8.25 (m, 1H), 7.87-7.63 (m, 7H), 7.59-7.55 (m, 1H), 7.51-7.48 (m, 2H), 6.31 (d, J=7.1 Hz, 1H), 5.24 (d, J=7.1 Hz, 1H), 3.62-3.49 (m, 1H), 2.83 (d, J=13.7 Hz, 1H), 1.62 (s, 3H), 1.59 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.51, ?81.96, ?82.25, ?82.70, ?110.01, ?110.02, ?110.26, ?110.27. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.76, 43.18, 42.60.

Example 96: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2-fluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0675] ##STR00417##

[0676] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.128 mmol) and 1-bromo-4-[(dimethylphosphoryl)methyl]-2-fluorobenzene (68 mg, 0.256 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (82 mg, 0.384 mmol) and Pd(dppf)Cl.sub.2 (10 mg, 0.013 mmol) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.1% NH.sub.3H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 18% B to 33% B in 10 min; Wave Length: 254/220 nm; RT1 (min); 11.92 to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-2-fluorophenyl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (23 mg, 34%) as a white solid. MS ESI calculated for C.sub.27H.sub.23F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 526.14, found 526.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.46-8.40 (m, 1H), 7.78 (d, J=8.5 Hz, 1H), 7.66 (s, 1H), 7.46-7.35 (m, 4H), 7.25-7.21 (m, 1H), 7.15-7.06 (m, 2H), 6.83 (t, J=73.4 Hz, 1H), 6.37 (d, J=7.2 Hz, 1H), 4.95 (t, J=6.6 Hz, 1H), 3.52-3.43 (m, 1H), 3.19 (d, J=14.8 Hz, 2H), 2.87 (d, J=13.2 Hz, 1H), 1.55 (s, 3H), 1.51 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.97, ?80.42, ?81.44, ?81.88, ?117.54. .sup.31P NMR (162 MHz, Chloroform-d) ? 40.27.

Example 97: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-methylpyridin-3-yl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0677] ##STR00418##

[0678] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-10-fluoro-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.119 mmol) and 3-bromo-6-(dimethylphosphoryl)-2-methylpyridine (44 mg, 0.178 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (76 mg, 0.357 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 70% gradient in 20 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-2-methylpyridin-3-yl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (37 mg, 55%) as a white solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 544.17, found 544.35. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.50 (m, 1H), 8.06 (t, J=6.5 Hz, 1H), 7.69 (d, J=6.8 Hz, 1H), 7.54 (d, J=10.1 Hz, 1H), 7.46 (t, J=8.2 Hz, 1H), 7.36-7.30 (m, 2H), 6.76 (t, J=72.7 Hz, 1H), 6.26 (d, J=6.8 Hz, 1H), 5.05 (d, J=6.7 Hz, 1H), 3.56-3.45 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 2.49 (s, 3H), 1.90 (s, 3H), 1.86 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.41, ?80.86, ?80.90, ?81.35, ?119.11. .sup.31P NMR (162 MHz, Chloroform-d) ? 36.38.

Example 98: (7R,14R)-1-(difluoromethoxy)-11-(6-(((dimethylphosphoryl)methyl)amino)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0679] ##STR00419##

Preparation 98A: (((5-bromopyridin-2-yl)amino)methyl)dimethylphosphine oxide

[0680] ##STR00420##

[0681] To a stirred solution of 5-bromopyridin-2-amine (410 mg, 2.372 mmol) in THF (3 mL) was added NaH (158 mg, 3.952 mmol, 60%) in portions at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at 50? C. under nitrogen atmosphere. To the above mixture was added chloro(dimethylphosphoryl)methane (200 mg, 1.581 mmol) in THF (1 mL) dropwise at 0? C. The resulting mixture was stirred for additional 3 h at room temperature. The reaction was quenched with Water/Ice at 0? C. and extract with CH.sub.2Cl.sub.2 (3?30 mL). The combined organic layer was concentrated under reduce pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 10/6 to 50% gradient in 20 min; detector, 254/220 nm to afford (((5-bromopyridin-2-yl)amino)methyl)dimethylphosphine oxide (50 mg, 12%) as a light yellow oil. MS ESI calculated for C.sub.8H.sub.12BrN.sub.2OP [M+H].sup.+, 262.99 264.99, found 262.75 264.75. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.06 (d, J=2.3 Hz, 1H), 7.64-7.40 (m, 1H), 6.63 (d, J=8.9 Hz, 1H), 6.43 (s, 1H), 3.97 (s, 2H), 1.61 (s, 3H), 1.59 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 45.42.

Example 98: (7R,14R)-1-(difluoromethoxy)-11-(6-(((dimethylphosphoryl)methyl)amino)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0682] ##STR00421##

[0683] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol) and (((5-bromopyridin-2-yl)amino)methyl)dimethylphosphine oxide (50 mg, 0.189 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (92 mg, 0.435 mmol) and Pd(dppf)Cl.sub.2 (12 mg, 0.014 mmol) in portions at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.1% NH.sub.3H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 14% B to 30% B in 10 min; Wave Length: 254/220 nm; RT1 (min); 11.93) to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(((dimethylphosphoryl)methyl)amino)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (29 mg, 36%) as a white solid. MS ESI calculated for C.sub.27H.sub.23D.sub.3F.sub.2N.sub.5O.sub.3P [M+H].sup.+, 541.19, found 541.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.44 (m, 1H), 8.20 (d, J=2.4 Hz, 1H), 7.81-7.72 (m, 2H), 7.54 (d, J=1.8 Hz, 1H), 7.42 (t, J=8.2 Hz, 1H), 7.36-7.29 (m, 2H), 7.06-6.68 (m, 2H), 6.24 (d, J=7.2 Hz, 1H), 4.95 (d, J=7.1 Hz, 1H), 3.98 (t, J=5.8 Hz, 2H), 3.52-3.42 (m, 1H), 2.87 (d, J=13.5 Hz, 1H), 1.66 (s, 3H), 1.63 (s, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.25, ?80.69, ?80.79, ?81.24. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.98.

Example 99 and 100: (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0684] ##STR00422## ##STR00423##

Preparation 99A: 1-(4-bromo-2-fluorophenyl)ethanol

[0685] ##STR00424##

[0686] To a stirred solution of 1-(4-bromo-2-fluorophenyl)ethanone (5.00 g, 23.038 mmol) in EtOH (50 mL) was added NaBH.sub.4 (1.74 g, 46.076 mmol) at 0? C. under nitrogen atmosphere. The mixture was stirred for 2 h at 0? C. under nitrogen atmosphere. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (4:1) to afford 1-(4-bromo-2-fluorophenyl)ethanol (5.01 g, 98%) as a yellow oil. MS ESI calculated for C.sub.8H.sub.8BrFO [M+H].sup.+, 218.97 220.97, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.38-7.34 (m, 1H), 7.29-7.27 (m, 1H), 7.20-7.17 (m, 1H), 5.12 (q, J=6.6 Hz, 1H), 1.47 (d, J=6.6 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?117.28.

Preparation 99B: 4-bromo-1-(1-bromoethyl)-2-fluorobenzene

[0687] ##STR00425##

[0688] To a stirred solution of 1-(4-bromo-2-fluorophenyl)ethanol (2.00 g, 9.130 mmol) in DCM (30 mL) was added PBr.sub.3 (2.97 g, 10.956 mmol) at 0? C. under nitrogen atmosphere. The mixture was stirred for 2 h at room temperature under nitrogen atmosphere. The reaction was quenched with water at room temperature. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE to afford 4-bromo-1-(1-bromoethyl)-2-fluorobenzene (2.00 g, 78%) as a colorless oil. MS ESI calculated for C.sub.8H.sub.7Br.sub.2F [M+H].sup.+, 280.89 282.89, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.42-7.37 (m, 1H), 7.32-7.28 (m, 1H), 7.24-7.21 (m, 1H), 5.40 (q, J=7.0 Hz, 1H), 2.02 (d, J=7.0 Hz, 3H).

Preparation 99C: 4-bromo-1-[1-(dimethylphosphoryl)ethyl]-2-fluorobenzene

[0689] ##STR00426##

[0690] To a stirred solution of (methylphosphonoyl)methane (0.55 g, 7.094 mmol) in THF (30 mL) was added NaHMDS (5.3 mL, 5.321 mmol, 1M in THF) at 0? C. under nitrogen atmosphere. The mixture was stirred for 15 min at 0? C. To the above mixture was added 4-bromo-1-(1-bromoethyl)-2-fluorobenzene (1.00 g, 3.547 mmol) at 0? C. The resulting mixture was stirred for additional 16 h at 20? C. The reaction was quenched with water at room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 4-bromo-1-[1-(dimethylphosphoryl)ethyl]-2-fluorobenzene (165 mg, 17%) as a yellow oil. MS ESI calculated for C.sub.10H.sub.13BrFOP [M+H].sup.+, 278.99 280.99, found 279.05 281.05.

Preparation 99D: (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0691] ##STR00427##

[0692] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (150 mg, 0.310 mmol) and 4-bromo-1-[1-(dimethylphosphoryl)ethyl]-2-fluorobenzene (86 mg, 0.310 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added K.sub.3PO.sub.4 (197 mg, 0.930 mmol) and Pd(dppf)Cl.sub.2 (25 mg, 0.031 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (120 mg, 67%). MS ESI calculated for C.sub.29H.sub.24D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 557.19, found 557.20.

Example 99 and 100: (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0693] ##STR00428##

[0694] (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (120 mg) was resolved by Chiral HPLC with the following conditions: Column: CHIRALPAK IH 3*25 cm, 5 ?m; Mobile Phase A: Hex (0.1% 2M NH.sub.3-MeOH), Mobile Phase B: EtOH/ACN=5:1; Flow rate: 45 mL/min; Gradient: isocratic 25; Wave Length: 212/288 nm; RT1 (min); 11.5; RT2 (min); 14.5. The first peak afforded 41 mg (23%) as a white solid. MS ESI calculated for C.sub.29H.sub.24D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 557.19, found 557.20. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.30-8.25 (m, 1H), 7.87-7.54 (m, 3H), 7.54-7.42 (m, 6H), 6.29 (d, J=7.1 Hz, 1H), 5.23 (d, J=7.1 Hz, 1H), 3.53-3.50 (m, 1H), 3.45-3.40 (m, 1H) 2.82 (d, J=13.8 Hz, 1H), 1.55-1.40 (m, 6H), 1.28-1.19 (m, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.67, ?82.13, ?82.25, ?82.69, ?116.59. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.57.

[0695] The second peak afforded 36 mg (21%) as a white solid. MS ESI calculated for C.sub.29H.sub.24D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 557.19, found 557.25. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.30-8.24 (m, 1H), 7.88-7.66 (m, 3H), 7.58-7.42 (m, 6H), 6.29 (d, J=7.1 Hz, 1H), 5.23 (d, J=7.1 Hz, 1H), 3.58-3.48 (m, 1H), 3.46-3.41 (m, 1H), 2.83 (d, J=13.8 Hz, 1H), 1.55-1.43 (m, 6H), 1.28-1.20 (m, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.62, ?82.07, ?82.25, ?82.71, ?116.62. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.65.

Example 101: (7R,14R)-11-(4-((diethylphosphoryl)(hydroxy)methyl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0696] ##STR00429##

Preparation 101A: ((4-bromophenyl)(hydroxy)methyl)diethylphosphine oxide

[0697] ##STR00430##

[0698] To a stirred solution of 4-bromobenzaldehyde (3.00 g, 16.214 mmol) and (ethylphosphonoyl)ethane (1.89 g, 17.835 mmol) in THF (30 mL) was added TEA (4.5 mL, 32.428 mmol) dropwise at room temperature. The resulting mixture was stirred for overnight at 55? C. The mixture was allowed to cool down to room temperature. The resulting mixture was stirred for 5 min at 0? C. The precipitated solids were collected by filtration and washed with EtOAc (3?5 mL). The resulting mixture was concentrated under vacuum to afford ((4-bromophenyl)(hydroxy)methyl)diethylphosphine oxide (4.10 g, 86%) as a white solid. MS ESI calculated for C.sub.11H.sub.16BrO.sub.2P [M+H].sup.+, 291.01 293.01, found 290.80 292.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.48 (d, J=8.2 Hz, 2H), 7.35-7.29 (m, 2H), 5.05 (d, J=7.3 Hz, 1H), 4.33 (s, 1H), 1.87-1.50 (m, 4H), 1.18-1.02 (m, 6H). .sup.31P NMR (162 MHz, Chloroform-d) ? 54.24.

Example 101: (7R,14R)-11-(4-((diethylphosphoryl)(hydroxy)methyl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0699] ##STR00431##

[0700] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and (4-bromophenyl)(diethylphosphoryl)methanol (39 mg, 0.134 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (66 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (8 mg, 0.010 mmol) in portions at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 40% to 70% gradient in 20 min, detector, 254/220 nm to afford (7R,14R)-11-(4-((diethylphosphoryl)(hydroxy)methyl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (24 mg, 40%) as a white solid. MS ESI calculated for C.sub.30H.sub.27D.sub.3F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 569.21, found 569.45. .sup.1H NMR (400 MHz, Methanol-d.sub.4) ? 8.43-8.30 (m, 1H), 7.83-7.78 (m, 1H), 7.70-7.62 (m, 3H), 7.59-7.52 (m, 3H), 7.50-7.43 (m, 2H), 7.29-7.08 (m, 1H), 6.45-6.39 (m, 1H), 5.23-5.10 (m, 2H), 3.65-3.50 (m, 1H), 2.95-2.84 (m, 1H), 2.02-1.86 (m, 2H), 1.83-1.61 (m, 2H), 1.30-1.19 (m, 3H), 1.10-0.99 (m, 3H). .sup.19F NMR (377 MHz, Methanol-d.sub.4) ? ?80.27, ?80.35, ?80.72, ?80.79, ?80.83, ?80.92, ?81.28, ?81.37. .sup.31P NMR (162 MHz, Methanol-d.sub.4) ? 57.13.

Example 102: (7R,14R)-1-(difluoromethoxy)-11-(2-(difluoromethyl)-4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0701] ##STR00432##

Preparation 102A: 1-bromo-2-(difluoromethyl)-4-iodobenzene

[0702] ##STR00433##

[0703] To a stirred mixture of 2-bromo-5-iodobenzaldehyde (2.00 g, 6.433 mmol) in DCM (40 mL) was added DAST (1.56 g, 9.649 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 0? C. under nitrogen atmosphere. The reaction was quenched with Water/Ice at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (2?100 mL). The resulting mixture was concentrated under vacuum. This resulted in 1-bromo-2-(difluoromethyl)-4-iodobenzene (2.00 g, 93%) as a colorless oil. MS ESI calculated for C.sub.7H.sub.4BrF.sub.2I [M+H].sup.+, 322.85 324.85, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.96-7.93 (m, 1H), 7.66-7.63 (m, 1H), 7.34-7.31 (m, 1H), 6.82 (t, J=54.6 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?115.14.

Preparation 102B: 1-bromo-2-(difluoromethyl)-4-(dimethylphosphoryl)benzene

[0704] ##STR00434##

[0705] To a stirred mixture of 1-bromo-2-(difluoromethyl)-4-iodobenzene (600 mg, 1.802 mmol) and (methylphosphonoyl)methane (155 mg, 1.982 mmol) in 1,4-dioxane (12 mL) were added K.sub.3PO.sub.4 (1.15 g, 5.406 mmol), XantPhos (104 mg, 0.180 mmol) and Pd.sub.2(dba).sub.3 (83 mg, 0.090 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 1-bromo-2-(difluoromethyl)-4-(dimethylphosphoryl)benzene (380 mg, 74%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.10BrF.sub.2OP [M+H].sup.+, 282.96 284.96, found 283.05 285.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.93 (d, J=11.4 Hz, 1H), 7.80-7.75 (m, 2H), 6.94 (t, J=54.6 Hz, 1H), 1.79 (s, 3H), 1.76 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?115.14. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.73.

Example 102: (7R,14R)-1-(difluoromethoxy)-11-(2-(difluoromethyl)-4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0706] ##STR00435##

[0707] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 1-bromo-2-(difluoromethyl)-4-(dimethylphosphoryl)benzene (38 mg, 0.134 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added K.sub.3PO.sub.4 (66 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(2-(difluoromethyl)-4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (21 mg, 37%) as a white solid. MS ESI calculated for C.sub.28H.sub.21D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 561.17, found 561.15. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.31-8.25 (m, 1H), 8.24-7.95 (m, 2H), 7.93-7.88 (m, 1H), 7.89-7.51 (m, 5H), 7.51-7.46 (m, 2H), 6.33 (d, J=7.1 Hz, 1H), 5.25 (d, J=7.1 Hz, 1H), 3.58-3.43 (m, 1H), 2.84 (d, J=13.8 Hz, 1H), 1.83 (s, 3H), 1.79 (s, 3H). .sup.19F NMR (377 MHz, DMSO.sub.6) ? ?81.50, ?81.95, ?82.08, ?82.53, ?105.45, ?106.25, ?107.20, ?108.00. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 32.5.

Example 103: (7R,14R)-1-(difluoromethoxy)-11-(3-(difluoromethyl)-4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0708] ##STR00436##

Preparation 103A: 4-bromo-2-(difluoromethyl)-1-iodobenzene

[0709] ##STR00437##

[0710] To a stirred mixture of 5-bromo-2-iodobenzaldehyde (2.00 g, 6.433 mmol) in DCM (40 mL) was added DAST (1.56 g, 9.678 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 0? C. under nitrogen atmosphere. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (2?100 mL). The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE to afford 4-bromo-2-(difluoromethyl)-1-iodobenzene (1.87 g, 87%) as a colorless oil. MS ESI calculated for C.sub.7H.sub.4BrF.sub.2I [M+H].sup.+, 332.85 334.85, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.75-7.71 (m, 2H), 7.31 (m, 1H), 6.69 (t, J=54.6 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?114.19.

Preparation 103B: 4-bromo-2-(difluoromethyl)-1-(dimethylphosphoryl)benzene

[0711] ##STR00438##

[0712] To a stirred mixture of 4-bromo-2-(difluoromethyl)-1-iodobenzene (600 mg, 1.802 mmol) and (methylphosphonoyl)methane (155 mg, 1.982 mmol) in 1,4-dioxane (12 mL) were added K.sub.3PO.sub.4 (1.15 g, 5.406 mmol), XantPhos (104 mg, 0.180 mmol) and Pd.sub.2(dba).sub.3 (83 mg, 0.090 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 4-bromo-2-(difluoromethyl)-1-(dimethylphosphoryl)benzene (300 mg, 59%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.10BrF.sub.2OP [M+H].sup.+, 282.96 284.96, found 283.05 285.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.02-8.00 (m, 1H), 7.98-7.40 (m, 2H), 7.40-7.34 (m, 1H), 1.84 (s, 3H), 1.81 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?115.14. .sup.31P NMR (162 MHz, Chloroform-d) ? 38.40.

Example 103: (7R,14R)-1-(difluoromethoxy)-11-(3-(difluoromethyl)-4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0713] ##STR00439##

[0714] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 4-bromo-2-(difluoromethyl)-1-(dimethylphosphoryl)benzene (38 mg, 0.134 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added K.sub.3PO.sub.4 (66 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (8 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. The resulting mixture was concentrated under vacuum. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(3-(difluoromethyl)-4-(dimethylphosphoryl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (23 mg, 40%) as a white solid. MS ESI calculated for C.sub.28H.sub.21D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 561.17, found 561.15. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.31-8.25 (m, 1H), 8.25-7.86 (m, 4H), 7.85-7.58 (m, 4H), 7.52-7.46 (m, 2H), 6.33 (d, J=7.1 Hz, 1H), 5.25 (d, J=7.1 Hz, 1H), 3.59-3.48 (m, 1H), 2.84 (d, J=13.8 Hz, 1H), 1.83 (s, 3H), 1.79 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?82.14, ?109.94. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 38.61.

Example 104: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-(trifluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0715] ##STR00440##

Preparation 104A: 1-bromo-4-(dimethylphosphoryl)-2-(trifluoromethyl)benzene

[0716] ##STR00441##

[0717] To a stirred mixture of 1-bromo-4-iodo-2-(trifluoromethyl)benzene (500 mg, 1.425 mmol), K.sub.3PO.sub.4 (907 mg, 4.275 mmol), XantPhos (82 mg, 0.143 mmol) and (methylphosphonoyl)methane (111 mg, 1.425 mmol) in 1,4-dioxane (5 mL) was added Pd.sub.2(dba).sub.3 (65 mg, 0.071 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 90? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford 1-bromo-4-(dimethylphosphoryl)-2-(trifluoromethyl)benzene (340 mg, 79%) as a black gray solid. MS ESI calculated for C.sub.9H.sub.9BrF.sub.3OP [M+H].sup.+, 300.95 302.95, found 301.05 303.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.04-7.96 (m, 1H), 7.90-7.83 (m, 1H), 7.80-7.70 (m, 1H), 1.78 (s, 3H), 1.75 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 33.21. .sup.19F NMR (377 MHz, Chloroform-d) ? ?62.83.

Example 104: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-(trifluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0718] ##STR00442##

[0719] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-(trifluoromethyl)benzene (37 mg, 0.124 mmol) in 1,4-dioxane (0.9 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (65 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (9 mg, 0.010 mmol) in portions at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 80? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-(trifluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (24 mg, 41%) as a white solid. MS ESI calculated for C.sub.29H.sub.20D.sub.3F.sub.5N.sub.3O.sub.3P [M+H].sup.+, 579.16, found 579.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.47 (m, 1H), 8.15-8.07 (m, 1H), 7.99-7.89 (m, 1H), 7.79 (d, J=8.4 Hz, 1H), 7.52-7.50 (m, 1H), 7.50-7.46 (m, 1H), 7.46-7.40 (m, 1H), 7.34-7.27 (m, 1H), 7.27-7.20 (m, 1H), 6.73 (t, J=72.7 Hz, 1H), 6.28 (d, J=7.1 Hz, 1H), 5.08 (d, J=6.9 Hz, 1H), 3.57-3.46 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 1.85 (s, 3H), 1.82 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?56.67, ?80.33, ?80.77, ?81.21, ?81.65. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.30.

Example 105: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0720] ##STR00443##

Preparation 105A: 4-bromo-1-(dimethylphosphoryl)-2-methylbenzene

[0721] ##STR00444##

[0722] To a stirred mixture of 4-bromo-1-iodo-2-methylbenzene (500 mg, 1.684 mmol), K.sub.3PO.sub.4 (1072 mg, 5.052 mmol), XantPhos (97 mg, 0.168 mmol) and (methylphosphonoyl)methane (131 mg, 1.684 mmol) in 1,4-dioxane (5 mL) was added Pd.sub.2(dba).sub.3 (77 mg, 0.084 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 90? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford 4-bromo-1-(dimethylphosphoryl)-2-methylbenzene (198 mg, 47%) as a yellow oil. MS ESI calculated for C.sub.9H.sub.12BrOP [M+H].sup.+, 246.96 248.96, found 247.05 249.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.58-7.48 (m, 1H), 7.47-7.40 (m, 2H), 2.64 (s, 3H), 1.82 (s, 3H), 1.79 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 35.50.

Example 105: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0723] ##STR00445##

[0724] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 4-bromo-1-(dimethylphosphoryl)-2-methylbenzene (31 mg, 0.124 mmol) in 1,4-dioxane (0.9 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 80? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (34 mg, 64%) as a white solid. MS ESI calculated for C.sub.28H.sub.23D.sub.3F.sub.2N.sub.3O.sub.3P [M+H].sup.+, 525.19, found 525.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.46 (m, 1H), 7.84-7.71 (m, 3H), 7.58-7.53 (m, 1H), 7.53-7.48 (m, 2H), 7.44 (t, J=8.3 Hz, 1H), 7.35-7.28 (m, 1H), 6.86 (t, J=72.8 Hz, 1H), 6.34 (d, J=7.1 Hz, 1H), 5.09 (d, J=7.0 Hz, 1H), 3.58-3.46 (m, 1H), 2.92 (d, J=13.6 Hz, 1H), 2.74 (s, 3H), 1.87 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.30, ?80.75, ?80.77, ?81.22. .sup.31P NMR (162 MHz, Chloroform-d) ? 35.18.

Example 106: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-5-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0725] ##STR00446## ##STR00447##

Preparation 106A: 5-bromo-2-(dimethylphosphoryl)-1-fluoro-3-methylbenzene

[0726] ##STR00448##

[0727] To a stirred mixture of 5-bromo-1-fluoro-2-iodo-3-methylbenzene (500 mg, 1.588 mmol), K.sub.3PO.sub.4 (1011 mg, 4.764 mmol), XantPhos (92 mg, 0.159 mmol) and (methylphosphonoyl)methane (124 mg, 1.588 mmol) in 1,4-dioxane (5 mL) was added Pd.sub.2(dba).sub.3 (73 mg, 0.079 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 90? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford 5-bromo-2-(dimethylphosphoryl)-1-fluoro-3-methylbenzene (98 mg, 23%) as a yellow oil. MS ESI calculated for C.sub.9H.sub.11BrFOP [M+H].sup.+, 264.97 266.97, found 264.95 267.00. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.25 (s, 1H), 7.19-7.08 (m, 1H), 2.77 (s, 3H), 1.86 (d, J=2.7 Hz, 3H), 1.82 (d, J=2.7 Hz, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?99.94. .sup.31P NMR (162 MHz, Chloroform-d) ? 35.89.

Example 106: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-5-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0728] ##STR00449##

[0729] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 5-bromo-2-(dimethylphosphoryl)-1-fluoro-3-methylbenzene (33 mg, 0.124 mmol) in 1,4-dioxane (0.9 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (9 mg, 0.010 mmol) in portions at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 80? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-5-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (19 mg, 34%) as a white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 543.18, found 543.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.47 (m, 1H), 7.83 (d, J=8.5 Hz, 1H), 7.78 (d, J=1.7 Hz, 1H), 7.57-7.50 (m, 1H), 7.46 (t, J=8.3 Hz, 1H), 7.34-7.29 (m, 2H), 7.19-7.11 (m, 1H), 6.89 (t, J=72.8 Hz, 1H), 6.36 (d, J=6.8 Hz, 1H), 5.14 (d, J=6.6 Hz, 1H), 3.58-3.50 (m, 1H), 2.94 (d, J=13.5 Hz, 1H), 2.86 (s, 3H), 1.90 (d, J=2.6 Hz, 3H), 1.86 (d, J=2.6 Hz, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.33, ?80.78, ?80.93, ?81.38, ?101.57. .sup.31P NMR (162 MHz, Chloroform-d) ? 35.60.

Example 107: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluoro-3-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0730] ##STR00450## ##STR00451##

Preparation 107A: 1-bromo-4-(dimethylphosphoryl)-2-fluoro-3-methylbenzene

[0731] ##STR00452##

[0732] To a stirred mixture of 1-bromo-2-fluoro-4-iodo-3-methylbenzene (500 mg, 1.588 mmol) and (methylphosphonoyl)methane (124 mg, 1.588 mmol) in 1,4-dioxane (5 mL) were added K.sub.3PO.sub.4 (1.01 g, 4.764 mmol), XantPhos (92 mg, 0.159 mmol) and Pd.sub.2(dba).sub.3 (73 mg, 0.079 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 90? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford 1-bromo-4-(dimethylphosphoryl)-2-fluoro-3-methylbenzene (350 mg, 83%) as a yellow solid. MS ESI calculated for C.sub.9H.sub.11BrFOP [M+H].sup.+, 264.97 266.97, found 265.05 267.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.55-7.46 (m, 1H), 7.38-7.28 (m, 1H), 2.63-2.58 (m, 3H), 1.84 (s, 3H), 1.81 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?107.18, ?107.20. .sup.31P NMR (162 MHz, Chloroform-d) ? 35.15.

Example 107: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluoro-3-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0733] ##STR00453##

[0734] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol) and 1-bromo-4-(dimethylphosphoryl)-2-fluoro-3-methylbenzene (33 mg, 0.124 mmol) in 1,4-dioxane (0.9 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (66 mg, 0.309 mmol) and Pd(dppf)Cl.sub.2 (9 mg, 0.010 mmol) at room temperature under nitrogen atmosphere. The mixture was stirred for 16 h at 80? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 50% gradient in 30 min; detector, 254 nm. to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2-fluoro-3-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (23 mg, 40%) as a white solid. MS ESI calculated for C.sub.29H.sub.22D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 543.18, found 543.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.46 (m, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.75-7.69 (m, 1H), 7.56-7.47 (m, 1H), 7.47-7.38 (m, 2H), 7.41-7.33 (m, 1H), 7.33-7.27 (m, 1H), 6.81 (t, J=73.5 Hz, 1H), 6.30 (d, J=7.1 Hz, 1H), 5.03 (d, J=7.1 Hz, 1H), 3.54-3.43 (m, 1H), 2.90 (d, J=13.6 Hz, 1H), 2.67-2.62 (m, 3H), 1.88 (s, 3H), 1.84 (s, 3H). .sup.191F NMR (377 MHz, Chloroform-d) ? ?79.92, ?80.37, ?81.14, ?81.15, ?81.59, ?81.60, ?119.67, ?119.68, ?119.69, ?119.70. .sup.31P NMR (162 MHz, Chloroform-d) ? 34.78, 34.73.

Example 108: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0735] ##STR00454## ##STR00455##

Preparation 108A: (4-bromo-2-fluoro-5-methylphenyl)methanol

[0736] ##STR00456##

[0737] To a stirred solution of 4-bromo-2-fluoro-5-methylbenzaldehyde (2.00 g, 9.215 mmol) in MeOH (30 mL) was added NaBH.sub.4 (0.38 g, 10.136 mmol) in portions at 0? C. The resulting mixture was stirred for 2 h at room temperature. The reaction was quenched with water at 0? C. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (5:1) to afford (4-bromo-2-fluoro-5-methylphenyl)methanol (1.95 g, 96%) as colorless oil. MS ESI calculated for C.sub.8H.sub.8BrFO [M+H].sup.+, 218.97 220.97, found N/A. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.33 (s, 1H), 7.31-7.29 (m, J H), 7.26 (s, J H), 4.71 (s, 2H), 2.38 (s, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?122.27.

Preparation 108B: 1-bromo 4-(bromomethyl)-5-fluoro-2-methylbenzene

[0738] ##STR00457##

[0739] To a stirred solution of (4-bromo-2-fluoro-5-methylphenyl)methanol (1.95 g, 8.902 mmol) in DCM (40 mL) was added PBr.sub.3 (1.3 mL, 13.353 mmol) dropwise at 0? C. The resulting mixture was stirred for 3 h at room temperature. The reaction was quenched by the addition of Water/Ice (30 mL) at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (2?40 mL). The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (0% to 20%) to afford 1-bromo-4-(bromomethyl)-5-fluoro-2-methylbenzene (2.40 g, 95%) as a yellow oil. MS ESI calculated for C.sub.8H.sub.7Br.sub.2F [M+H].sup.+, 280.89 282.89, found N/A.

Preparation 108C: (4-bromo-2-fluoro-5-methylbenzyl)dimethylphosphine oxide

[0740] ##STR00458##

[0741] To a stirred solution of dimethylphosphine oxide (0.61 g, 7.803 mmol) in THF (35 mL) at room temperature under nitrogen atmosphere. The mixture was allowed to cool down to 0? C. To the above mixture was added NaHMDS (3.90 mL, 7.803 mmol, 2 M in THF) dropwise at 0? C. The resulting mixture was stirred for additional 30 min at room temperature. To the above mixture was added 1-bromo-4-(bromomethyl)-5-fluoro-2-methylbenzene (2.20 g, 7.803 mmol) in THF (5.0 mL) dropwise at 0? C. The resulting mixture was stirred for additional overnight at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The aqueous layer was extracted with EtOAc (3?50 mL). The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (4-bromo-2-fluoro-5-methylbenzyl)dimethylphosphine oxide (380 mg, 17%) as a white solid. MS ESI calculated for C.sub.10H.sub.13BrFOP [M+H].sup.+, 278.99 280.99, found 278.85 280.75. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.30 (d, J=9.1 Hz, 1H), 7.23 (d, J=7.7 Hz, 1H), 3.15 (d, J=14.9 Hz, 2H), 2.35 (s, 3H), 1.53 (s, 3H), 1.50 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?119.56, ?119.56. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.28.

Example 108: (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0742] ##STR00459##

[0743] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and (4-bromo-2-fluoro-5-methylbenzyl)dimethylphosphine oxide (42 mg, 0.149 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (79 mg, 0.372 mmol) and Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 20% B to 35% B in 10 min; Wave Length: 254/220 nm; RT1 (min); 12.82) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-((dimethylphosphoryl)methyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (19 mg, 27%) as a white solid. MS ESI calculated for C.sub.29H.sub.24D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 557.19, found 557.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.46 (m, 1H), 7.74 (d, J=8.4 Hz, 1H), 7.46-7.37 (m, 2H), 7.34-7.30 (m, 1H), 7.24-7.20 (m, 1H), 7.19-7.14 (m, 1H), 6.99-6.57 (m, 2H), 6.24 (d, J=7.2 Hz, 1H), 4.97 (d, J=7.0 Hz, 1H), 3.53-3.41 (m, 1H), 3.21 (d, J=14.9 Hz, 2H), 2.88 (d, J=13.6 Hz, 1H), 2.18 (s, 3H), 1.56 (s, 3H), 1.53 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.22, ?80.66, ?81.00, ?81.44, ?122.04, ?122.04. .sup.31P NMR (162 MHz, Chloroform-d) ? 41.20.

Example 109: (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0744] ##STR00460## ##STR00461##

Preparation 109A: 1-(4-bromo-2,6-difluorophenyl)ethanol

[0745] ##STR00462##

[0746] To a stirred solution of 1-(4-bromo-2,6-difluorophenyl)ethanone (2.00 g, 8.510 mmol) in MeOH (20 mL) was added NaBH.sub.4 (354 mg, 9.361 mmol) in portions at 0? C. The resulting mixture was stirred for 1 h at room temperature. The reaction was quenched with Water at 0? C. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?50 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 1-(4-bromo-2,6-difluorophenyl)ethanol (1.91 g, 94%) as a colorless liquid. MS ESI calculated for C.sub.8H.sub.7BrF.sub.20 [M+H].sup.+, 236.96 238.96, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.11-7.04 (m, 2H), 5.24-5.16 (m, 1H), 1.61 (d, J=6.7 Hz, 3H).

Preparation 109B: 5-bromo-2-(1-bromoethyl)-1,3-difluorobenzene

[0747] ##STR00463##

[0748] To a stirred solution of 1-(4-bromo-2,6-difluorophenyl)ethanol (1.00 g, 4.219 mmol) in DCM (10 mL) was added PBr.sub.3 (1.71 g, 6.329 mmol) dropwise at 0? C. The resulting mixture was stirred for 3 h at room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (10/1) to afford 5-bromo-2-(1-bromoethyl)-1,3-difluorobenzene (960 mg, 75%) as a colorless oil. MS ESI calculated for C.sub.8H.sub.6Br.sub.2F.sub.2 [M+H].sup.+, 298.88 300.88 302.88, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.09 (d, J=8.7 Hz, 2H), 5.47-5.38 (m, 1H), 2.08 (d, J=7.1 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?110.32.

Preparation 109C: 5-bromo-2-[1-(dimethylphosphoryl)ethyl]-1,3-difluorobenzene

[0749] ##STR00464##

[0750] To a stirred solution of (methylphosphonoyl)methane (100 mg, 1.284 mmol) in THF (5 mL, 61.714 mmol) was added 2M NaHDMS (0.64 mL, 1.284 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at 0? C. under nitrogen atmosphere. To the above mixture was added 5-bromo-2-(1-bromoethyl)-1,3-difluorobenzene (350 mg, 1.167 mmol) at 0? C. The resulting mixture was stirred for additional 16 h at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The resulting mixture was extracted with EtOAc (3?50 mL). The combined organic layers were washed with brine (100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 5-bromo-2-[1-(dimethylphosphoryl)ethyl]-1,3-difluorobenzene (130 mg, 37%) as a colorless oil. MS ESI calculated for C.sub.10H.sub.12BrF.sub.2OP [M+H].sup.+, 296.98 298.98, found 296.90 298.90.

Preparation 109D: (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0751] ##STR00465##

[0752] To a stirred solution of 5-bromo-2-[1-(dimethylphosphoryl)ethyl]-1,3-difluorobenzene (92 mg, 0.309 mmol) and (7R,14R)-1-(fluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (100 mg, 0.206 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (17 mg, 0.021 mmol) and K.sub.3PO.sub.4 (131 mg, 0.618 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 59/6) as a white solid. MS ESI calculated for C.sub.29H.sub.23D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 575.18, found 575.30.

Example 109: (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0753] ##STR00466##

[0754] (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg) was resolved by Chiral-HPLC with the following conditions (Column: JW-CHIRAL ART Cellulose-SZ, 3.0*50 mm, 3 um; Mobile Phase A: Hex (0.1% 2M NH.sub.3-MeOH), Mobile Phase B: EtOH; Flow rate: 40 mL/min; Gradient: isocratic 30; Wave Length: 202/306 nm; RT1 (min); 14; RT2 (min); 6.5). The first peak afforded 24 mg (32%) as a white solid. MS ESI calculated for C.sub.29H.sub.23D.sub.3F.sub.4NIO.sub.3P [M+H].sup.+, 575.18, found 575.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.82 (d, J=8.4 Hz, 1H), 7.71 (s, 1H), 7.55-7.41 (m, 2H), 7.34 (d, J=8.0 Hz, 1H), 7.16 (d, J=10.8 Hz, 2H), 6.89 (t, J=71.9 Hz, 1H), 6.35 (s, 1H), 5.22-5.05 (m, 1H), 3.72-3.60 (m, 1H), 3.61-3.45 (m, 1H), 2.99-2.87 (m, 1H), 1.80-1.66 (m, 3H), 1.59-1.45 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.48, ?80.93, ?80.94, ?81.39, ?109.45. .sup.31P NMR (162 MHz, Chloroform-d) ? 46.72.

Example 110 and 111: (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0755] ##STR00467## ##STR00468##

Preparation 110A: (1-(4-bromophenyl)-1-hydroxyethyl)dimethylphosphine oxide

[0756] ##STR00469##

[0757] Into a 8-mL vial were added 1-(4-bromophenyl)ethan-1-one (200 mg, 1.005 mmol) and dimethylphosphine oxide (227 mg, 2.914 mmol) at room temperature. The resulting mixture was stirred for 5 h at 80? C. The mixture was allowed to cool down to room temperature. The resulting mixture was purified by trituration with EtOAc (10 mL). This result in (1-(4-bromophenyl)-1-hydroxyethyl)dimethylphosphine oxide (110 mg, 39%) as a white solid. MS ESI calculated for C.sub.10H.sub.14BrO.sub.2P [M+H].sup.+, 276.99 278.99, found 277.05 279.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.54-7.49 (m, 2H), 7.42 (d, J=8.2 Hz, 2H), 1.87 (d, J=12.5 Hz, 3H), 1.47 (d, J=12.2 Hz, 3H), 1.35 (d, J=12.2 Hz, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 53.72.

Preparation 110B: (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0758] ##STR00470##

[0759] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.165 mmol) and (1-(4-bromophenyl)-1-hydroxyethyl)dimethylphosphine oxide (60 mg, 0.215 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (105 mg, 0.495 mmol) and Pd(dppf)Cl.sub.2 (13 mg, 0.017 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 60% gradient in 20 min; detector, 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (45 mg, 49%) as a white solid. MS ESI calculated for C.sub.29H.sub.25D.sub.3F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 555.20, found 555.05.

Example 110 and 111: (7R,14R)-1-(difluoromethoxy)-1-(4-((S or R)-1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0760] ##STR00471##

[0761] (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)-1-hydroxyethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (45 mg) was separated by Chiral Prep-HPLC with the following conditions (Column: Lux 5 um Cellulose-2 3*15 cm, 5 ?m; Mobile Phase A: Hex (10 mM NH.sub.3-MeOH), Mobile Phase B: EtOH; Flow rate: 40 mL/min; Gradient: isocratic 50; Wave Length: 208/236 nm; RT1 (min); 11.73; RT2 (min); 13.41). The first peak afforded 14 mg (30%) as a white solid. MS ESI calculated for C.sub.29H.sub.25D.sub.3F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 555.20, found 555.30. .sup.1H NMR (400 MHz, Methanol-d.sub.4) ? 8.41-8.28 (m, 1H), 7.85-7.74 (m, 1H), 7.71-7.59 (m, 5H), 7.58-7.05 (m, 4H), 6.44-6.33 (m, 1H), 5.21-5.10 (m, 1H), 3.64-3.44 (m, 1H), 2.93-2.77 (m, 1H), 1.89-1.79 (m, 3H), 1.66-1.55 (m, 3H), 1.32-1.18 (m, 3H). .sup.19F NMR (376 MHz, Methanol-d.sub.4) ? ?82.85, ?82.91, ?83.30, ?83.36, ?83.57, ?83.64, ?84.02, ?84.10. .sup.31P NMR (162 MHz, Methanol-d.sub.4) ? 57.32. The last peak afforded 13 mg (29%) as a white solid. MS ESI calculated for C.sub.29H.sub.25D.sub.3F.sub.2N.sub.3O.sub.4P [M+H].sup.+, 555.20, found 555.40. .sup.1H NMR (400 MHz, Methanol-d.sub.4) ? 8.40-8.29 (m, 1H), 7.83-7.75 (m, 1H), 7.72-7.59 (m, 5H), 7.57-7.06 (m, 4H), 6.48-6.32 (m, 1H), 5.24-5.08 (m, 1H), 3.62-3.47 (m, 1H), 2.94-2.77 (m, 1H), 1.93-1.79 (m, 3H), 1.69-1.56 (m, 3H), 1.34-1.16 (m, 3H). .sup.19F NMR (376 MHz, Methanol-d.sub.4) ? ?82.78, ?82.85, ?83.23, ?83.30, ?83.64, ?83.71, ?84.09, ?84.16. .sup.31P NMR (162 MHz, Methanol-d.sub.4) ? 57.31.

Example 112: (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0762] ##STR00472##

[0763] (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg) was resolved by Chiral-HPLC with the following conditions (Column: JW-CHIRAL ART Cellulose-SZ, 3.0*50 mm; 3 um; Mobile Phase A: Hex (0.1% 2M NH.sub.3-MeOH), Mobile Phase B: EtOH; Flow rate: 40 mL/min; Gradient: isocratic 30; Wave Length: 202/306 nm; RT1 (min); 14; RT2 (min); 6.5). The second peak afforded 17 mg (25%) as a white solid. MS ESI calculated for C.sub.29H.sub.23D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 575.18, found 575.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.1 Hz, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.68 (s, 1H), 7.44 (t, J=8.3 Hz, 2H), 7.33 (d, J=8.0 Hz, 1H), 7.16 (d, J=10.6 Hz, 2H), 6.89 (t, J=72.8 Hz, 1H), 6.31 (d, J=6.4 Hz, 1H), 5.08-4.97 (m, 1H), 3.74-3.59 (m, 1H), 3.55-3.42 (m, 1H), 2.91 (d, J=13.4 Hz, 1H), 1.76-1.71 (m, 3H), 1.53 (d, J=4.5 Hz, 3H), 1.50 (d, J=4.5 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.88, ?110.27. .sup.31P NMR (162 MHz, Chloroform-d) ? 46.97.

Example 113 and 114: (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0764] ##STR00473## ##STR00474##

Preparation 113A: 1-(4-bromo-2-fluoro-3-methylphenyl)ethanone

[0765] ##STR00475##

[0766] To a stirred mixture of methyl 4-bromo-2-fluoro-3-methylbenzoate (2.00 g, 8.095 mmol) and sodium methanesulfinate (2.48 g, 24.285 mmol) in Toluene (20 mL) was added sodium LIHMDS (24.3 mL, 24.285 mmol, 1M in THF) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 75? C. under nitrogen atmosphere. The reaction was quenched with Water at room temperature. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?50 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (20:1) to afford 1-(4-bromo-2-fluoro-3-methylphenyl)ethanone (650 mg, 35%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.8BrFO [M+H].sup.+, 230.97 232.97, found N/A. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.63-7.56 (m, 1H), 7.47-7.42 (m, 1H), 2.79-2.55 (m, 3H), 2.53-2.35 (m, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?107.77.

Preparation 113B: 1-(4-bromo-2-fluoro-3-methylphenyl)ethanol

[0767] ##STR00476##

[0768] A mixture of 1-(4-bromo-2-fluoro-3-methylphenyl)ethanone (600 mg, 2.597 mmol) and NaBH.sub.4 (196 mg, 5.194 mmol) in EtOH (6 mL) was stirred for 2 h at 0? C. under nitrogen atmosphere. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?50 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (10:1) to afford 1-(4-bromo-2-fluoro-3-methylphenyl)ethanol (380 mg, 62%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.10BrFO [M+H].sup.+, 232.99 234.99, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.36-7.32 (m, 1H), 7.23-7.18 (m, 1H), 5.14 (q, J=6.5 Hz, 1H), 2.34-2.32 (m, 3H), 1.51-1.47 (m, 3H).

Preparation 113C: 1-bromo-4-(1-bromoethyl)-3-fluoro-2-methylbenzene

[0769] ##STR00477##

[0770] To a stirred solution of 1-(4-bromo-2-fluoro-3-methylphenyl)ethanol (380 mg, 1.630 mmol) in DCM (7 mL) was added PBr.sub.3 (529 mg, 1.956 mmol) at 0? C. under nitrogen atmosphere. The mixture was stirred for 2 h at room temperature. The reaction was quenched with water at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?50 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE to afford 1-bromo-4-(1-bromoethyl)-3-fluoro-2-methylbenzene (270 mg, 56%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.9Br.sub.2F [M+H].sup.+, 294.91 296.91 298.91, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.37-7.33 (m, 1H), 7.25-7.20 (m, 1H), 5.43 (q, J=7.0 Hz, 1H), 2.34 (d, J=2.6 Hz, 3H), 2.02 (d, J=7.0 Hz, 3H).

Preparation 113D: 1-bromo-4-[1-(dimethylphosphoryl)ethyl]-3-fluoro-2-methylbenzene

[0771] ##STR00478##

[0772] To a stirred solution of (methylphosphonoyl)methane (82 mg, 1.054 mmol) in THF (5 mL) was added 1M NaHMDS (1.0 mL, 0.966 mmol) at 0? C. under nitrogen atmosphere. The mixture was stirred for 15 min at 0? C. To the above mixture was added 1-bromo-4-(1-bromoethyl)-3-fluoro-2-methylbenzene (260 mg, 0.878 mmol) at 0? C. The resulting mixture was stirred for additional 16 h at 20? C. under nitrogen atmosphere. The reaction was quenched with water at room temperature. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 1-bromo-4-[1-(dimethylphosphoryl)ethyl]-3-fluoro-2-methylbenzene (60 mg, 23%) as a yellow oil. MS ESI calculated for C.sub.11H.sub.15BrFOP [M+H].sup.+, 293.00 295.00, found 293.15 295.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.84-7.74 (m, 1H), 6.66-6.59 (m, 1H), 3.11-3.05 (m, 1H), 1.66-1.64 (m, 3H), 1.64-1.62 (m, 3H), 1.61 (s, 3H), 1.60 (s, 3H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?115.42. .sup.31P NMR (162 MHz, Chloroform-d) ? 47.83.

Preparation 113E: (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0773] ##STR00479##

[0774] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.165 mmol) and 1-bromo-4-[1-(dimethylphosphoryl)ethyl]-3-fluoro-2-methylbenzene (62 mg, 0.215 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added K.sub.3PO.sub.4 (105 mg, 0.495 mmol) and Pd(dppf)Cl.sub.2 (13 mg, 0.017 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 60% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 63%) as a white solid. MS ESI calculated for C.sub.30H.sub.26D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 571.21, found 571.30.

Example 113 and 114: (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0775] ##STR00480##

[0776] (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-3-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg) was resolved by Chiral HPLC with the following conditions: Column: CHIRALPAK IE-3, 3.0*50 mm, 3 ?m; Mobile Phase A: Hex (10 mM NH.sub.3-MeOH), Mobile Phase B: EtOH; Flow rate: 40 mL/min; Gradient: isocratic 50; Wave Length: 206/268 nm; RT1 (min); 16.34; RT2 (min); 23.43. The first peak afforded 18 mg (19%) as a white solid. MS ESI calculated for C.sub.30H.sub.26D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 571.21, found 571.25. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.35-8.20 (m, 1H), 7.74-7.30 (m, 6H), 7.25-7.17 (m, 1H), 7.13-7.02 (m, 1H), 6.25 (d, J=7.0 Hz, 1H), 5.24 (d, J=7.0 Hz, 1H), 3.58-3.45 (m, 2H), 2.82 (d, J=13.8 Hz, 1H), 2.12 (s, 3H), 1.59-1.40 (m, 6H), 1.32-1.22 (m, 3H). .sup.19F NMR (376 MHz, DMSO-d.sub.6) ? ?81.60, ?82.05, ?82.10, ?82.55, ?118.70. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 43.90.

[0777] The second peak afforded 16 mg (17%) as a white solid. MS ESI calculated for C.sub.30H.sub.26D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 571.21, found 571.30. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.37-8.24 (m, 1H), 7.76-7.67 (m, 1H), 7.60-7.29 (m, 5H), 7.26-7.18 (m, 1H), 7.14-7.04 (m, 1H), 6.26 (d, J=7.1 Hz, 1H), 5.25 (d, J=7.1 Hz, JH), 3.56-3.51 (m, 2H), 2.83 (d, J=13.7 Hz, 1H), 2.13 (s, 3H), 1.58-1.41 (m, 6H), 1.33-1.20 (m, 3H). .sup.19F NMR (376 MHz, DMSO-d.sub.6) ? ?81.59, ?82.04, ?82.07, ?82.52, ?118.72, ?118.74. .sup.31P NMR (162 MHz, DMSO-d.sub.6?) ? 43.99.

Example 115: (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-6-fluoropyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0778] ##STR00481## ##STR00482##

Preparation 115A: 6-chloro-3-(dimethylphosphoryl)-2-fluoropyridine

[0779] ##STR00483##

[0780] To a stirred solution of 6-chloro-2-fluoro-3-iodopyridine (1.00 g, 3.885 mmol) and (methylphosphonoyl)methane (303 mg, 3.885 mmol) in 1,4-dioxane (25 mL) were added K.sub.3PO.sub.4 (2.47 g, 11.655 mmol), Pd.sub.2(dba).sub.3 (178 mg, 0.194 mmol) and XantPhos (225 mg, 0.389 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduce pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (8/1) to afford 6-chloro-3-(dimethylphosphoryl)-2-fluoropyridine (387 mg, 48%) as yellow solid. MS ESI calculated for C.sub.7H.sub.8ClFNOP [M+H].sup.+, 208.00, found 208.15. .sup.1H NMR (400 MHz, Methanol-d.sub.4) ? 8.36-8.23 (m, 1H), 7.65-7.53 (m, 1H), 1.88 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (376 MHz, Methanol-d.sub.4) ? ?59.03, ?59.07. .sup.31P NMR (162 MHz, Methanol-d.sub.4) ? 35.94, 35.85.

Example 115: (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-6-fluoropyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0781] ##STR00484##

[0782] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 6-chloro-3-(dimethylphosphoryl)-2-fluoropyridine (31 mg, 0.149 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (79 mg, 0.372 mmol) and Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was concentrated under reduce pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) followed by Prep-HPLC with the following conditions (Column: YMC-Actus Triart C18 ExRS 30*150 mm, 5 ?m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 18% B to 35.3% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 11) to afford (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-6-fluoropyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (34 mg, 52%) as white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 530.16, found 530.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.55-8.42 (m, 2H), 8.32 (d, J=1.7 Hz, 1H), 8.04-7.98 (m, 1H), 7.87-7.78 (m, 2H), 7.45 (t, J=8.2 Hz, 1H), 7.35 (d, J=8.2 Hz, 1H), 7.19-6.72 (m, 1H), 6.40 (d, J=7.1 Hz, 1H), 5.16 (d, J=7.1 Hz, 1H), 3.61-3.51 (m, 1H), 2.95 (d, J=13.6 Hz, 1H), 1.88 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?58.26, ?58.30, ?80.22, ?80.67, ?81.06, ?81 0.50. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.27, 30.17.

Example 116: (7R,14R)-1-(difluoromethoxy)-11-(6-(1-(dimethylphosphoryl)ethyl)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0783] ##STR00485## ##STR00486##

Preparation 116A: 5-bromo-2-(1-bromoethyl)pyridine

[0784] ##STR00487##

[0785] To a stirred solution of 5-bromo-2-ethylpyridine (2.50 g, 13.437 mmol) and NBS (2.39 g, 13.437 mmol) in DCE (25 mL) was added AIBN (26 mg, 0.161 mmol) in portions at room temperature. The resulting mixture was stirred for 3 h at 85? C. The mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (5/1) to afford 5-bromo-24(1-bromoethyl)pyridine (3.10 g, 87%) as yellow oil. MS ESI calculated for C.sub.7H.sub.7Br.sub.2N. [M+H].sup.+, 263.89 265.89 267.89 found 264.05 266.10 268.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.62 (d, J=2.4 Hz, 1H), 7.84-7.82 (m, 1H), 7.36 (d, J=8.4 Hz, 1H), 5.19 (q, J=6.9 Hz, 1H), 2.09-2.02 (m, 3H).

Preparation 116B: 5-bromo-2-[1-(dimethylphosphoryl)ethyl]pyridine

[0786] ##STR00488##

[0787] A solution of (methylphosphonoyl)methane (972 mg, 12.455 mmol) and NaHMDS (12.5 mL, 12.455 mmol) in THF (10 mL) was stirred for 30 min at 0? C. under nitrogen atmosphere. To the above mixture was added 5-bromo-2-(1-bromoethyl)pyridine (3.00 g, 11.323 mmol) in THF (10 mL) dropwise over 5 min at 0? C. The resulting mixture was stirred for additional overnight at room temperature. The resulting mixture was extracted with EtOAc (3?50 mL). The aqueous layer was concentrated under reduced pressure. The residue was purified by reversed-phase flash chromatography with the following conditions: column, C18 silica gel, mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 40% to 50% gradient in 10 min; detector, 254 nm to afford 5-bromo-2-[1-(dimethylphosphoryl)ethyl]pyridine (81 mg, 3%) as yellow oil. MS ESI calculated for C.sub.9H.sub.13BrNOP [M+H].sup.+, 261.99, 263.99 found 262.15, 264.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.61 (d, J=2.3 Hz, 1H), 7.91-7.74 (m, 1H), 7.30 (d, J=8.5 Hz, 1H), 3.50-3.29 (m, 1H), 1.70-1.56 (m, 3H), 1.52-1.40 (m, 6H). .sup.31P NMR (162 MHz, Chloroform-d) ? 46.21.

Example 116: (7R,14R)-1-(difluoromethoxy)-11-(6-(1-(dimethylphosphoryl)ethyl)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0788] ##STR00489##

[0789] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol) and 5-bromo-2-[1-(dimethylphosphoryl)ethyl]pyridine (45 mg, 0.174 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (92 mg, 0.435 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (12 mg, 0.014 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was concentrated under reduces pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) followed by Prep-HPLC with the following conditions (Column: XBridge Shield RP18 OBD Column 30*150 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 12% B to 32% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 10.97) to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(1-(dimethylphosphoryl)ethyl)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (38 mg, 49%) as white solid. MS ESI calculated for C.sub.28H.sub.24D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 540.20, found 540.35. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.78 (s, 1H), 8.50 (d, J=8.3 Hz, 1H), 8.10-8.00 (m, 1H), 7.83 (d, J=8.4 Hz, 1H), 7.70 (s, 1H), 7.66-7.57 (m, 1H), 7.49-7.42 (m, 2H), 7.33 (d, J=8.4 Hz, 1H), 6.88 (t, J=72.8 Hz, 1H), 6.30 (d, J=7.2 Hz, 1H), 5.00 (d, J=7.0 Hz, 1H), 3.73-3.59 (m, 1H), 3.56-3.42 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 1.79-1.67 (m, 3H), 1.61-1.45 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.37, ?80.81, ?80.83, ?80.86, ?81.29. .sup.31P NMR (162 MHz, Chloroform-d) ? 46.13.

Example 117: (7R,14R)-11-(3-chloro-4-(dimethylphosphoryl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0790] ##STR00490## ##STR00491##

Preparation 117A: 4-bromo-2-chloro-1-(dimethylphosphoryl)benzene

[0791] ##STR00492##

[0792] To a stirred mixture of 4-bromo-2-chloro-1-iodobenzene (1.00 g, 3.151 mmol) and (methylphosphonoyl)methane (246 mg, 3.151 mmol) in 1,4-dioxane (20 mL) were added K.sub.3PO.sub.4 (2.0 g, 9.453 mmol), XantPhos (182 mg, 0.315 mmol) and Pd.sub.2(dba).sub.3 (144 mg, 0.158 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 70? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 4-bromo-2-chloro-1-(dimethylphosphoryl)benzene (500 mg, 59%) as a white solid. MS ESI calculated for C.sub.8H.sub.9BrClOP [M+H].sup.+, 266.93 268.93, found 267.05 269.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.07-7.99 (m, 1H), 7.65-7.59 (m, 2H), 1.92 (s, 3H), 1.88 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 34.20.

Example 117: (7R,14R)-11-(3-chloro-4-(dimethylphosphoryl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0793] ##STR00493##

[0794] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol) and 4-bromo-2-chloro-1-(dimethylphosphoryl)benzene (58 mg, 0.217 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added K.sub.3PO.sub.4 (92 mg, 0.435 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (12 mg, 0.014 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-11-(3-chloro-4-(dimethylphosphoryl)phenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (64 mg, 81%) as a white solid. MS ESI calculated for C.sub.27H.sub.20D.sub.3ClF.sub.2N.sub.3O.sub.3P [M+H].sup.+, 545.13, found 545.15. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.34-8.21 (m, 1H), 8.06-7.95 (m, 1H), 7.90-7.56 (m, 6H), 7.54-7.47 (m, 2H), 6.31 (d, J=7.1 Hz, 1H), 5.24 (d, J=7.1 Hz, 1H), 3.59-3.47 (m, 1H), 2.84 (d, J=13.8 Hz, 1H), 1.85 (s, 3H), 1.81 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.65, ?82.10, ?82.23, ?82.68. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 31.72.

Example 118 and 119: (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0795] ##STR00494## ##STR00495##

Preparation 118A: 1-(4-bromo-2-fluoro-5-methylphenyl)ethan-1-ol

[0796] ##STR00496##

[0797] Into a 250 mL round-bottom flask were added 4-bromo-2-fluoro-5-methylbenzaldehyde (3.00 g, 13.823 mmol) and THF (100 mL) at room temperature under nitrogen atmosphere. The mixture was allowed to cool down to 0? C. To the above mixture was added CH.sub.3MgBr (15.2 mL, 15.205 mmol) dropwise at 0? C. The resulting mixture was stirred for additional 5 h at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The aqueous layer was extracted with EtOAc (3?100 mL). The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (10:1) to afford 1-(4-bromo-2-fluoro-5-methylphenyl)ethan-1-ol (580 mg, 18%) as a light yellow oil. MS ESI calculated for C.sub.9H.sub.10BrFO [M+H].sup.+, 232.99 234.99, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.35 (d, J=7.8 Hz, 1H), 7.22 (d, J=9.7 Hz, 1H), 5.13 (q, J=6.5 Hz, 1H), 2.36 (s, 3H), 1.49 (d, J=6.5 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?122.57.

Preparation 118B: 1-bromo-4-(1-bromoethyl)-5-fluoro-2-methylbenzene

[0798] ##STR00497##

[0799] To a stirred solution of 1-(4-bromo-2-fluoro-5-methylphenyl)ethanol (500 mg, 2.145 mmol) in DCM (8 mL) was added PBr.sub.3 (0.3 mL, 3.218 mmol) dropwise at 0? C. The resulting mixture was stirred for 3 h at room temperature. The reaction was quenched with Water/Ice at 0? C. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?30 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (12:1) to afford 1-bromo-4-(1-bromoethyl)-5-fluoro-2-methylbenzene (270 mg, 42%) as a colorless oil. MS ESI calculated for C.sub.9H.sub.9Br.sub.2F [M+H].sup.+, 294.91 296.91 298.91, found N/A. .sup.1H NMR (300 MHz, Chloroform-d) ? 7.37 (d, J=7.7 Hz, 1H), 7.23 (s, 1H), 5.45-5.32 (q, J=7.0 Hz, 1H), 2.37 (s, 3H), 2.02 (d, J=7.0 Hz, 3H). .sup.19F NMR (282 MHz, Chloroform-d) ? ?119.67.

Preparation 118C: (1-(4-bromo-2-fluoro-5-methylphenyl)ethyl)dimethylphosphine oxide

[0800] ##STR00498##

[0801] To a stirred solution of (methylphosphonoyl)methane (71 mg, 0.912 mmol) in THF (6 mL) was added NaHMDS (0.91 mL, 0.912 mmol, 1M in THF) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at room temperature under nitrogen atmosphere. To the above mixture was added 1-bromo-4-(1-bromoethyl)-5-fluoro-2-methylbenzene (270 mg, 0.912 mmol) dropwise at 0? C. The resulting mixture was stirred for additional overnight at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at 0? C. The aqueous layer was extracted with EtOAc (3?20 mL). The organic layers were dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (1-(4-bromo-2-fluoro-5-methylphenyl)ethyl)dimethylphosphine oxide (58 mg, 21%) as a yellow oil. MS ESI calculated for C.sub.11H.sub.15BrFOP [M+H].sup.+, 293.00 295.00, found 292.90 294.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.32 (d, J=7.7 Hz, 1H), 7.29 (s, 1H), 2.37 (s, 3H), 1.93-1.86 (m, 6H), 1.34 (d, J=11.6 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?120.07. .sup.31P NMR (162 MHz, Chloroform-d) ? 46.63.

Preparation 118D: (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0802] ##STR00499##

[0803] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.165 mmol) and 1-bromo-4-[1-(dimethylphosphoryl)ethyl]-5-fluoro-2-methylbenzene (58 mg, 0.198 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (105 mg, 0.495 mmol) and Pd(dppf)Cl.sub.2 (14 mg, 0.017 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 60% gradient in 30 min; detector, 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (65 mg, 68%) as a white solid. MS ESI calculated for C.sub.30H.sub.26D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 571.21, found 571.20.

Example 118 and 119: (7R,14R)-1-(difluoromethoxy)-11-(4-((R or S)-1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and (7R,14R)-1-(difluoromethoxy)-11-(4-((S or R)-1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0804] ##STR00500##

[0805] (7R,14R)-1-(difluoromethoxy)-11-(4-(1-(dimethylphosphoryl)ethyl)-5-fluoro-2-methylphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (65 mg) was separated by SFC with the following conditions (Column: CHIRALPAK IH 3*25 cm, 5 ?m; Mobile Phase A: CO.sub.2, Mobile Phase B: MeOH (20 mM NH.sub.3); Flow rate: 100 mL/min; Gradient: isocratic 20% B; Wave Length: 230/210 nm; RT1 (min); 10.1; RT2 (min); 11.82). The first peak afforded 22 mg (34%) as a white solid. MS ESI calculated for C.sub.30H.sub.26D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 571.21, found 571.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.46 (m, 1H), 7.74 (d, J=8.4 Hz, 1H), 7.46-7.39 (m, 2H), 7.36-7.28 (m, 2H), 7.20-7.15 (m, 1H), 6.97-6.59 (m, 2H), 6.24 (d, J=7.2 Hz, 1H), 4.98 (d, J=7.1 Hz, 1H), 3.55-3.36 (m, 2H), 2.88 (d, J=13.5 Hz, 1H), 2.20 (s, 3H), 1.70-1.64 (m, 3H), 1.57 (d, J=12.3 Hz, 3H), 1.39 (d, J=12.3 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.21, ?80.65, ?81.00, ?81.44, ?122.35, ?122.36. .sup.31P NMR (162 MHz, Chloroform-d) ? 45.79.

[0806] The second peak afforded 19 mg (29%) as a white solid. MS ESI calculated for C.sub.30H.sub.26D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 571.21, found 571.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.45 (m, 1H), 7.81-7.72 (m, 1H), 7.46-7.39 (m, 2H), 7.35-7.28 (m, 2H), 7.24-7.17 (m, 1H), 6.98-6.60 (m, 2H), 6.31-6.22 (m, 1H), 5.15-4.95 (m, 1H), 3.57-3.36 (m, 2H), 2.96-2.84 (m, 1H), 2.20 (s, 3H), 1.71-1.63 (m, 3H), 1.57 (d, J=12.2 Hz, 3H), 1.39 (d, J=12.3 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.29, ?80.74, ?80.97, ?81.41, ?122.20, ?122.26. .sup.31P NMR (162 MHz, Chloroform-d) ? 45.60.

Example 120: (7R,14R)-1-(difluoromethoxy)-11-(6-(2-(dimethylphosphoryl)propan-2-yl)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0807] ##STR00501## ##STR00502##

Preparation 120A: 1-(5-bromopyridin-2-yl)-1-(dimethylphosphoryl)ethanol

[0808] ##STR00503##

[0809] A mixture of 1-(5-bromopyridin-2-yl)ethanone (2.00 g, 9.998 mmol) and (methylphosphonoyl)methane (0.94 g, 11.998 mmol) was stirred for overnight at 80? C. under nitrogen atmosphere. The mixture was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) to afford 1-(5-bromopyridin-2-yl)-1-(dimethylphosphoryl)ethanol (2.10 g, 75%) as a white solid. MS ESI calculated for C.sub.9H.sub.3BrNO.sub.2P [M+H].sup.+, 277.99 279.99, found 278.05 280.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.61 (d, J=2.4 Hz, 1H), 7.94-7.88 (m, 1H), 7.70-7.64 (m, 1H), 5.31 (s, 1H), 1.79 (d, J=12.4 Hz, 3H), 1.62 (d, J=12.8 Hz, 3H), 1.15 (d, J=12.4 Hz, 3H).

Preparation 120B: 1-(5-bromopyridin-2-yl)-1-(dimethylphosphoryl)ethyl methanesulfonate

[0810] ##STR00504##

[0811] To a solution of 1-(5-bromopyridin-2-yl)-1-(dimethylphosphoryl)ethanol (600 mg, 2.158 mmol) in THF (10 mL) was added NaH (104 mg, 2.590 mmol, 60%) at 0 degrees C. The mixture was stirred for 15 min. MsCl (0.20 mL, 2.590 mmol) was added and the mixture was allowed to warm to room temperature and stirred for overnight. The reaction was quenched with water (20 mL) at 0? C. and was extracted with DCM (2?20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 1-(5-bromopyridin-2-yl)-1-(dimethylphosphoryl)ethyl methanesulfonate (150 mg, 19%) as a light yellow solid. MS ESI calculated for C.sub.10H.sub.15BrNO.sub.4PS [M+H].sup.+, 355.96 357.96, found 356.05 358.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.68 (d, J=2.3 Hz, 1H), 7.96-7.89 (m, 1H), 7.48 (d, J=8.6 Hz, 1H), 3.29 (s, 3H), 2.40-2.33 (m, 3H), 1.63 (d, J=12.6 Hz, 3H), 1.48 (d, J=12.9 Hz, 3H). .sup.31P NMR (162 MHz, Chloroform-d)) ? 50.19.

Preparation 120C: 5-bromo-2-[2-(dimethylphosphoryl)propan-2-yl]pyridine

[0812] ##STR00505##

[0813] To a stirred solution of 1-(5-bromopyridin-2-yl)-1-(dimethylphosphoryl)ethyl methanesulfonate (150 mg, 0.421 mmol) in DCM (3 mL) was added AlMe.sub.3 (1.7 mL, 3.368 mmol, 2M in Toluene) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for overnight at room temperature. The reaction was quenched with sat. NaHCO.sub.3 (aq.) at 0? C. and extracted with DCM (2?20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford 5-bromo-2-[2-(dimethylphosphoryl)propan-2-yl]pyridine (60 mg, 51%) as a light yellow solid. MS ESI calculated for C.sub.10H.sub.15BrNOP [M+H].sup.+, 276.01 278.01, found 275.85 277.85. .sup.1H-NMR (400 MHz, Chloroform-d) ? 8.67-8.56 (m, 1H), 7.85-7.73 (m, 1H), 7.43 (d, J=8.5 Hz, 1H), 1.67 (s, 3H), 1.63 (s, 3H), 1.40 (s, 3H), 1.37 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 51.91.

Example 120: (7R,14R)-1-(difluoromethoxy)-11-(6-(2-(dimethylphosphoryl)propan-2-yl)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0814] ##STR00506##

[0815] To a solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (70 mg, 0.145 mmol) and 5-bromo-2-[2-(dimethylphosphoryl)propan-2-yl]pyridine (48 mg, 0.174 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (92 mg, 0.434 mmol) and Pd(dppf)Cl.sub.2 (12 mg, 0.014 mmol). After stirring for 3 h at 80? C. under a nitrogen atmosphere, the mixture was allowed to cool down to room temperature. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.1% NH.sub.3.Math.H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min mL/min; Gradient: 17% B to 32% B in 10 min; Wave Length: 254 nm/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(2-(dimethylphosphoryl)propan-2-yl)pyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (51 mg, 63%) as a white solid. MS ESI calculated for C.sub.29H.sub.26D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 554.21, found 554.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.81 (d, J=2.4 Hz, 1H), 8.52-8.44 (m, 1H), 7.93-7.87 (m, 1H), 7.81 (d, J=8.5 Hz, 1H), 7.70 (d, J=1.7 Hz, 1H), 7.64-7.58 (m, 1H), 7.51-7.47 (m, 1H), 7.43 (t, J=8.2 Hz, 1H), 7.36-7.31 (m, 1H), 6.86 (t, J=72.8 Hz, 1H), 6.30 (d, J=7.2 Hz, 1H), 5.01 (d, J=7.1 Hz, 1H), 3.55-3.42 (m, 1H), 2.90 (d, J=13.6 Hz, 1H), 1.75 (s, 3H), 1.72 (s, 3H), 1.46 (s, 3H), 1.43 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.30, ?80.74, ?80.91, ?81.36. .sup.31P NMR (162 MHz, Chloroform-d) ? 52.68.

Example 121: (7R,14R)-11-(6-chloro-5-(dimethylphosphoryl)pyridin-2-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0816] ##STR00507## ##STR00508##

Preparation 121A: 6-bromo-2-chloro-3-(dimethylphosphoryl)pyridine

[0817] ##STR00509##

[0818] To a stirred solution of 6-bromo-2-chloro-3-iodopyridine (2.00 g, 6.283 mmol) and (methylphosphonoyl)methane (441 mg, 5.655 mmol) in 1,4-dioxane (20 mL) were added K.sub.3PO.sub.4 (4.00 g, 18.849 mmol), XantPhos (364 mg, 0.628 mmol) and Pd.sub.2(dba).sub.3 (288 mg, 0.314 mmol) at room temperature. The resulting mixture was stirred for 2 h at 70? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford 6-bromo-2-chloro-3-(dimethylphosphoryl)pyridine (150 mg, 9%) as a brown solid. MS ESI calculated for C.sub.7H.sub.8BrClNOP [M+H].sup.+, 267.92 269.92, found 267.95 269.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.38-8.30 (m, 1H), 7.67-7.61 (m, 1H), 1.95 (s, 3H), 1.91 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 33.10.

Example 121: (7R,14R)-11-(6-chloro-5-(dimethylphosphoryl)pyridin-2-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0819] ##STR00510##

[0820] To a stirred mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and 6-bromo-2-chloro-3-(dimethylphosphoryl)pyridine (53 mg, 0.198 mmol) in 1,4-dioxane (1.5 mL) and H.sub.2O (0.3 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-11-(6-chloro-5-(dimethylphosphoryl)pyridin-2-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (42 mg, 62%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3ClF.sub.2N.sub.4O.sub.3P [M+H].sup.+, 546.13, found 546.10. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.37-8.31 (m, 1H), 8.30-8.21 (m, 2H), 8.12-8.04 (m, 1H), 7.99-7.89 (m, 1H), 7.83-7.42 (m, 4H), 6.42-6.28 (m, 1H), 5.35-5.16 (m, 1H), 3.55-3.51 (m, 1H), 2.84 (d, J=13.7 Hz, 1H), 1.88 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?81.44, ?81.89, ?81.96, ?82.41. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 31.52.

Example 122: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-(trifluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0821] ##STR00511## ##STR00512##

Preparation 122A: (4-bromo-2-(trifluoromethyl)phenyl)dimethylphosphine oxide

[0822] ##STR00513##

[0823] To a stirred solution of dimethylphosphine oxide (667 mg, 8.549 mmol) and 4-bromo-1-iodo-2-(trifluoromethyl)benzene (3.00 g, 8.549 mmol) in 1,4-dioxane (15 mL) were added K.sub.3PO.sub.4 (2.72 g, 12.823 mmol) and Pd.sub.2(dba).sub.3 (391 mg, 0.427 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was filtered, the filter cake was washed with CH.sub.2Cl.sub.2 (3?10 mL). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0%?10%) to afford 4-bromo-1-(dimethylphosphoryl)-2-(trifluoromethyl)benzene (500 mg, 19%) as a yellow solid. MS ESI calculated for C.sub.9H.sub.9BrF.sub.3OP [M+H].sup.+, 300.95, found 300.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.42-8.32 (m, 1H), 7.99-7.83 (m, 2H), 1.88 (s, 3H), 1.84 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?56.61. .sup.31P NMR (162 MHz, Chloroform-d) ? 34.82.

Example 122: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-(trifluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0824] ##STR00514##

[0825] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.124 mmol) and 4-bromo-1-(dimethylphosphoryl)-2-(trifluoromethyl)benzene (60 mg, 0.149 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (105 mg, 0.372 mmol) and Pd(dppf)Cl.sub.2 (14 mg, 0.012 mmol) at room temperature. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford followed by Prep-HPLC with the following conditions (Column. YMC-Actus Triart C18 ExRS 30*150 mm, 5 ?m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 20% B to 38% B in 10 min; Wave Length: 254/220 nm; RT1 (min); 12) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-(trifluoromethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (57 mg, 79%) as a white solid. MS ESI calculated for C.sub.28H.sub.20D.sub.3F.sub.5N.sub.3O.sub.3P [M+H].sup.+, 579.16, found 579.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.66-8.46 (m, 2H), 8.12-7.82 (m, 4H), 7.62 (d, J=8.5 Hz, 1H), 7.46 (t, J=8.3 Hz, 1H), 7.32 (d, J=8.3 Hz, 1H), 6.88 (t, J=72.8 Hz, 1H), 6.38 (d, J=6.7 Hz, 1H), 5.17 (d, J=6.7 Hz, 1H), 3.62-3.47 (m, 1H), 2.96 (d, J=13.4 Hz, 1H), 1.92 (s, 3H), 1.88 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?56.40, ?80.41, ?80.86, ?81.07, ?81.52. .sup.31P NMR (162 MHz, Chloroform-d) ? 34.42.

Example 123: (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-4-fluoro-6-methylpyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0826] ##STR00515## ##STR00516##

Preparation 123A: 6-chloro-3-iodo-2-methylpyridin-4-amine

[0827] ##STR00517##

[0828] To a stirred solution of 2-chloro-6-methylpyridin-4-amine (9.50 g, 66.625 mmol) in EtOH (280 mL) were added Ag.sub.2SO.sub.4 (20.77 g, 66.625 mmol) and I.sub.2 (16.91 g, 66.625 mmol) at room temperature. The resulting mixture was stirred for overnight at room temperature. To the above mixture were added EtOAc (100 mL) and TEA (9.26 mL, 66.625 mmol). The resulting mixture was stirred for additional 10 min at room temperature. The resulting mixture was filtered, the filter cake was washed with EtOAc (3?50 mL). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (4/1) to afford 6-chloro-3-iodo-2-methylpyridin-4-amine (5.10 g, 28%) as a white solid. MS ESI calculated for C.sub.6H.sub.6ClIN.sub.2 [M+H].sup.+, 268.93, found 268.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 6.43 (s, 1H), 4.80 (s, 2H), 2.65 (s, 3H).

Preparation 123B: 6-chloro-4-fluoro-3-iodo-2-methylpyridine

[0829] ##STR00518##

[0830] To a cold solution (0? C.) of 6-chloro-3-iodo-2-methylpyridin-4-amine (2.00 g, 7.449 mmol) in anhydrous hydrogen fluoride-pyridine solution (70%, w/w, 12 mL) in a Teflon round-bottom flask, was added NaNO.sub.2 (0.77 g, 11.174 mmol) in port. The reaction mixture was stirred at 0? C. for 1 h. After warming to room temperature, the flask was equipped with a Teflon water-cooled condenser and the reaction mixture was heated at 70? C. until no gas evolution was observed. After cooling to room temperature, crushed ice (100 g) and dichloromethane (100 mL) were added. After decantation, the aqueous layer was extracted with dichloromethane (3?100 mL). The combined organic layers were dried over Na.sub.2SO.sub.4, filtered and evaporated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (3:1) to afford 6-chloro-4-fluoro-3-iodo-2-methylpyridine (1.60 g, 79%) as a yellow oil. MS ESI calculated for C.sub.6H.sub.4ClFIN [M+H].sup.+, 271.91, found 272.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 6.90 (d, J=6.7 Hz, 1H), 2.77 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?78.18.

Preparation 123C: (6-chloro-4-fluoro-2-methylpyridin-3-yl)dimethylphosphine oxide

[0831] ##STR00519##

[0832] To a stirred solution of 6-chloro-4-fluoro-3-iodo-2-methylpyridine (1.60 g, 5.894 mmol) and (methylphosphonoyl)methane (0.51 g, 6.483 mmol) in 1,4-dioxane (10 mL) were added K.sub.3PO.sub.4 (1.88 g, 8.841 mmol) and Pd.sub.2(dba).sub.3 (0.27 g, 0.295 mmol) at room temperature. The resulting mixture was stirred for 2 h at 90? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. The resulting mixture was filtered, the filter cake was washed with DCM (3?5 mL). The filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (6-chloro-4-fluoro-2-methylpyridin-3-yl)dimethylphosphine oxide (280 mg, 21%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.10ClFNOP [M+H].sup.+, 222.02, found 221.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.02-6.95 (m, 1H), 2.97 (s, 3H), 1.87 (d, J=2.5 Hz, 3H), 1.84 (d, J=2.5 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?90.81. .sup.31P NMR (162 MHz, Chloroform-d) 32.60.

Example 123: (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-4-fluoro-6-methylpyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0833] ##STR00520##

[0834] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and (6-chloro-4-fluoro-2-methylpyridin-3-yl)dimethylphosphine oxide (28 mg, 0.124 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min; detector, 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-4-fluoro-6-methylpyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-on (48 mg, 71%) as a white solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 544.17, found 544.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.44 (m, 2H), 7.97-7.82 (m, 2H), 7.46 (t, J=8.2 Hz, 1H), 7.38-7.31 (m, 2H), 6.96 (t, J=72.7 Hz, 1H), 6.47-6.39 (m, 1H), 5.28-5.11 (m, 1H), 3.65-3.49 (m, 1H), 3.09 (s, 3H), 2.96 (d, J=12.0 Hz, 1H), 1.91 (s, 3H), 1.88 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.23, ?80.68, ?80.78, ?81.23, ?92.66. .sup.31P NMR (162 MHz, Chloroform-d) ? 32.94.

Example 124: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-fluoropyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0835] ##STR00521##

[0836] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and (5-bromo-3-fluoropyridin-2-yl)dimethylphosphine oxide (31 mg, 0.124 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (79 mg, 0.372 mmol) and Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) at room temperature. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min; detector, 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-fluoropyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (7 mg, 10%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 530.16, found 530.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.81 (s, 1H), 8.50 (d, J=8.2 Hz, 1H), 7.85 (d, J=8.5 Hz, 1H), 7.75 (s, 1H), 7.69-7.63 (m, 1H), 7.53-7.39 (m, 2H), 7.33 (d, J=8.1 Hz, 1H), 6.87 (t, J=72.8 Hz, 1H), 6.32 (d, J=6.9 Hz, 1H), 5.06-4.98 (m, 1H), 3.55-3.43 (m, 1H), 2.92 (d, J=13.5 Hz, 1H), 1.96 (s, 3H), 1.93 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.33, ?80.78, ?80.80, ?81.25, ?116.89. .sup.31P NMR (162 MHz, Chloroform-d) ? 35.22.

Example 125: (7R,14R)-11-(4-(diethylphosphoryl)-3-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0837] ##STR00522##

Preparation 125A: (4-bromo-2-fluorophenyl)diethylphosphine oxide

[0838] ##STR00523##

[0839] A mixture of 4-bromo-2-fluoro-1-iodobenzene (200 mg, 0.665 mmol), (ethylphosphonoyl)ethane (74 mg, 0.698 mmol), Pd.sub.2(dba).sub.3 (30 mg, 0.033 mmol), XantPhos (39 mg, 0.067 mmol) and K.sub.3PO.sub.4 (423 mg, 1.995 mmol) in 1,4-dioxane (2 mL) was stirred for 2 h at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford (4-bromo-2-fluorophenyl)diethylphosphine oxide (167 mg, 90%) as brown oil. MS ESI calculated for C.sub.10H.sub.13BrFOP [M+H].sup.+, 278.99 280.99, found 279.10 281.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.90-7.78 (m, 1H), 7.53-7.46 (m, 1H), 7.34-7.28 (m, 1H), 2.13-1.89 (m, 4H), 1.20-1.04 (m, 6H). .sup.191F NMR (377 MHz, Chloroform-d) ? ?103.28, ?103.31. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.53, 42.47.

Example 125: (7R,14R)-11-(4-(diethylphosphoryl)-3-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0840] ##STR00524##

[0841] A mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol), 4-bromo-1-(diethylphosphoryl)-2-fluorobenzene (35 mg, 0.124 mmol), K.sub.3PO.sub.4 (44 mg, 0.206 mmol) and Pd(dppf)Cl.sub.2 (8 mg, 0.010 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.1 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed purified by Prep-HPLC with the following conditions (Column: YMC-Actus Triart C18 ExRS 30*150 mm, 5 ?m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.05% NH.sub.3H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min mL/min; Gradient: 27% B to 44.2% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 9.85) to afford (7R,14R)-11-(4-(diethylphosphoryl)-3-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (13 mg, 22%) as a white solid. MS ESI calculated for C.sub.29H.sub.24D.sub.3F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 557.19, found 557.25. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.49 (d, J=8.2 Hz, 1H), 8.08-7.97 (m, 1H), 7.81 (d, J=8.5 Hz, 1H), 7.79-7.73 (m, 1H), 7.59-7.50 (m, 2H), 7.47-7.39 (m, 1H), 7.37-7.28 (m, 2H), 6.87 (t, J=72.8 Hz, 1H), 6.32 (d, J=7.1 Hz, 1H), 5.06 (d, J=7.0 Hz, 1H), 3.56-3.45 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 2.21-1.96 (m, 4H), 1.22-1.09 (m, 6H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.38, ?80.83, ?80.85, ?81.30, ?105.29, ?105.31. .sup.31P NMR (162 MHz, Chloroform-d) ? 42.52, 42.47.

Example 126: (7R,14R)-11-(6-(diethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0842] ##STR00525##

Preparation 126A: (5-bromopyridin-2-yl)diethylphosphine oxide

[0843] ##STR00526##

[0844] A mixture of 5-bromo-2-iodopyridine (200 mg, 0.704 mmol), (ethylphosphonoyl)ethane (78 mg, 0.739 mmol), Pd.sub.2(dba).sub.3 (65 mg, 0.070 mmol), XantPhos (41 mg, 0.070 mmol) and K.sub.3PO.sub.4 (299 mg, 1.408 mmol) in 1,4-dioxane (2 mL) was stirred for 2 h at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford (5-bromopyridin-2-yl)diethylphosphine oxide (140 mg, 76%) as brown oil. MS ESI calculated for C.sub.9H.sub.13BrNOP [M+H].sup.+, 261.99 263.99, found 262.10 264.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.76-8.70 (m, 1H), 7.99-7.90 (m, 2H), 2.04-1.93 (m, 4H), 1.11-0.97 (m, 6H). .sup.31P NMR (162 MHz, Chloroform-d) ? 46.00.

Example 126: (7R,14R)-11-(6-(diethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0845] ##STR00527##

[0846] A mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol), 5-bromo-2-(diethylphosphoryl)pyridine (33 mg, 0.124 mmol), Pd(dppf)Cl.sub.2 (8 mg, 0.010 mmol) and K.sub.3PO.sub.4 (44 mg, 0.206 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.1 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed purified by Prep-HPLC with the following conditions (Column: YMC-Actus Triart C18 ExRS 30*150 mm, 5 ?m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.05% NH.sub.3H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min mL/min; Gradient: 20% B to 37.5% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 10.38) to afford (7R,14R)-11-(6-(diethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (28 mg, 50%) as a white solid. MS ESI calculated for C.sub.28H.sub.24D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 540.20, found 540.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.98-8.93 (m, 1H), 8.55-8.48 (m, 1H), 8.23-8.17 (m, 1H), 8.05-8.01 (m, 1H), 7.91-7.83 (m, 1H), 7.80-7.73 (m, 1H), 7.58-7.53 (m, 1H), 7.48-7.39 (m, 1H), 7.38-7.31 (m, 1H), 6.87 (t, J=72.8 Hz, 1H), 6.35 (d, J=7.0 Hz, 1H), 5.14-5.07 (m, 1H), 3.61-3.46 (m, 1H), 2.97-2.87 (m, 1H), 2.17-2.01 (m, 4H), 1.22-1.07 (m, 6H). .sup.19F NMR (376 MHz, Chloroform-d) ? ?80.83, ?80.84. .sup.31P NMR (162 MHz, Chloroform-d) 45.54.

Example 127: (7R,14R)-11-(6-(diethylphosphoryl)-5-fluoropyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0847] ##STR00528##

Preparation 127A: (5-bromo-3-fluoropyridin-2-yl)diethylphosphine oxide

[0848] ##STR00529##

[0849] A mixture of 2,5-dibromo-3-fluoropyridine (200 mg, 0.785 mmol), (ethylphosphonoyl)ethane (87 mg, 0.824 mmol), XantPhos (45 mg, 0.079 mmol), K.sub.3PO.sub.4 (499 mg, 2.355 mmol) and Pd.sub.2(dba).sub.3 (72 mg, 0.079 mmol) in 1,4-dioxane (2 mL) was stirred for 2 h at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford (5-bromo-3-fluoropyridin-2-yl)diethylphosphine oxide (143 mg, 65%) as brown oil. MS ESI calculated for C.sub.9H.sub.12BrFNOP [M+H].sup.+, 279.98 281.98, found 280.05 282.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.61 (s, 1H), 7.71-7.63 (m, 1H), 2.23-1.92 (m, 4H), 1.24-1.06 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?113.07, ?113.10. .sup.31P NMR (162 MHz, Chloroform-d) ? 46.42, 46.34.

Example 127: (7R,14R)-11-(6-(diethylphosphoryl)-5-fluoropyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0850] ##STR00530##

[0851] A mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol), (5-bromo-3-fluoropyridin-2-yl)diethylphosphine oxide (35 mg, 0.124 mmol), Pd(dppf)Cl.sub.2 (8 mg, 0.010 mmol) and K.sub.3PO.sub.4 (44 mg, 0.206 mmol) in 1,4-dioxane (0.9 mL) and H.sub.2O (0.1 mL) was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel, mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min; detector, 254 nm. This resulted in (7R,14R)-11-(6-(diethylphosphoryl)-5-fluoropyridin-3-yl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (26 mg, 45%) as a white solid. MS ESI calculated for C.sub.28H.sub.23D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 558.19, found 558.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.88-8.76 (m, 1H), 8.58-8.46 (m, 1H), 7.93-7.85 (m, 1H), 7.80-7.77 (m, 1H), 7.68-7.62 (m, 1H), 7.56-7.51 (m, 1H), 7.49-7.42 (m, 1H), 7.37-7.32 (m, 1H), 6.89 (t, J=72.8 Hz, 1H), 6.36 (d, J=7.1 Hz, 1H), 5.12 (d, J=7.1 Hz, 1H), 3.60-3.46 (m, 1H), 2.99-2.92 (m, JH), 2.34-2.09 (m, 4H), 1.30-1.16 (m, 6H). .sup.19F NMR (376 MHz, Chloroform) ? ?80.41, ?80.86, ?80.90, ?81.35, ?116.46, ?116.49. .sup.31P NMR (162 MHz, Chloroform-d) ? 45.69, 45.62.

Example 128: (7R,14R)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-1-(trifluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0852] ##STR00531##

[0853] Preparation 128A: (7R,14R)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

##STR00532##

[0854] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (140 mg, 0.265 mmol) in THF (2 mL) was added KHMDS (1.32 mL, 1.325 mmol, 1 M in THF) dropwise at 0? C. under nitrogen atmosphere. The mixture was stirred for 2 h at room temperature. The reaction was quenched by the addition of sat. NH.sub.4Cl (aq.) (50 mL) at 0? C. and extracted with CH.sub.2Cl.sub.2 (3?50 mL). The combined organic layers were washed with brine (3?80 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) to afford (7R,14R)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 47%) as a white solid. MS ESI calculated for C.sub.26H.sub.20D.sub.3FN.sub.3O.sub.3P [M+H].sup.+, 479.16, found 479.20. .sup.1H NMR (400 MHz, Methanol-da) ? 8.07-8.02 (m, 1H), 7.96 (d, J=8.2 Hz, 1H), 7.93-7.82 (m, 1H), 7.75-7.50 (m, 4H), 7.25-7.16 (m, 1H), 7.12-7.06 (m, 1H), 6.56 (d, J=6.9 Hz, 1H), 5.22 (d, J=7.0 Hz, 1H), 3.58-3.46 (m, 1H), 2.86 (d, J=13.7 Hz, 1H), 1.89 (s, 3H), 1.86 (s, 3H). .sup.19F NMR (377 MHz, Methanol-d.sub.4) ? ?106.70. .sup.31P NMR (162 MHz, Methanol-d.sub.4) ? 36.70.

Example 128: (7R,14R)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-1-(trifluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0855] ##STR00533##

[0856] To a stirred solution of (7R,14R)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-1-hydroxy-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (100 mg, 0.209 mmol) and trimethyl(trifluoromethyl)silane (297 mg, 2.090 mmol) in Toluene (2 mL) and (trifluoromethyl)benzene (2 mL) were added Selectfluor (370 mg, 1.045 mmol), CsF (317 mg, 2.090 mmol), NFSI (329 mg, 1.045 mmol), silver trifluoromethanesulfonate (537 mg, 2.090 mmol) and 2-fluoropyridine (203 mg, 2.090 mmol) at room temperature. The resulting mixture was stirred for 36 h at 50? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min. This resulted in (7R,14R)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-1-(trifluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (5 mg, 4%) as a white solid. MS ESI calculated for C.sub.22H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.62-8.56 (m, 1H), 8.09-7.99 (m, 1H), 7.84 (d, J=8.5 Hz, 1H), 7.67 (s, 1H), 7.58-7.43 (m, 4H), 7.35-7.28 (m, 1H), 6.24 (d, J=6.8 Hz, 1H), 5.13 (d, J=6.5 Hz, 1H), 3.63-3.51 (m, 1H), 2.96 (d, J=13.4 Hz, 1H), 1.86 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?56.87, ?105.58. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.54.

Example 129: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-5-methoxyphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0857] ##STR00534##

Preparation 129A: (4-bromo-2-fluoro-6-methoxyphenyl)dimethylphosphine oxide

[0858] ##STR00535##

[0859] To a stirred solution of 5-bromo-1-fluoro-2-iodo-3-methoxybenzene (450 mg, 1.360 mmol) and (methylphosphonoyl)methane (106 mg, 1.360 mmol) in 1,4-dioxane (10 mL) were added K.sub.3PO.sub.4 (866 mg, 4.080 mmol), Pd.sub.2(dba).sub.3 (62 mg, 0.068 mmol) and XantPhos (79 mg, 0.136 mmol) at room temperature. The resulting mixture was stirred for overnight at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduce pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) to afford (4-bromo-2-fluoro-6-methoxyphenyl)dimethylphosphine oxide (75 mg, 19%) as yellow oil. MS ESI calculated for C.sub.9H.sub.11BrFO.sub.2P [M+H].sup.+, 280.97 282.97 found 281.00 282.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.00-6.86 (m, 2H), 3.93 (d, J=1.5 Hz, 3H), 1.89 (s, 3H), 1.86 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?101.28, ?109.46, ?109.48. .sup.31P NMR (162 MHz, Chloroform-d) ? 33.19.

Example 129: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-5-methoxyphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0860] ##STR00536##

[0861] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and (4-bromo-2-fluoro-6-methoxyphenyl)dimethylphosphine oxide (42 mg, 0.149 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.1 mL) were added K.sub.3PO.sub.4 (79 mg, 0.372 mmol) and Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was concentrated under reduce pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (9/1) followed by Prep-HPLC with the following conditions (Column: XBridge Shield RP18 OBD Column 30*150 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3+0.05% NH.sub.3.Math.H.sub.2O), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 15% B to 35% B in 10 min; Wave Length: 254 nm/220 nm; RT1 (min); 11.33) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluoro-5-methoxyphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (35 mg, 51%) as white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.4P [M+H].sup.+, 559.17 found 559.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53-8.43 (m, 1H), 7.83 (d, J=8.5 Hz, 1H), 7.76 (d, J=1.7 Hz, 1H), 7.54-7.50 (m, J H), 7.45 (t, J=8.2 Hz, 1H), 7.31 (d, J=8.2 Hz, 1H), 7.08-6.67 (m, 3H), 6.35 (d, J=7.1 Hz, 1H), 5.11 (d, J=7.1 Hz, 1H), 4.00 (s, 3H), 3.57-3.47 (m, 1H), 2.93 (d, J=13.6 Hz, 1H), 1.94 (d, J=2.4 Hz, 3H), 1.90 (d, J=2.4 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.84, ?80.29, ?80.81, ?81.26, ?102.40. .sup.31P NMR (162 MHz, Chloroform-d) ? 32.38.

Example 130: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-5-fluoro-2-methoxyphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0862] ##STR00537## ##STR00538##

Preparation 130A: (4-bromo-2-fluoro-5-methoxyphenyl)dimethylphosphine oxide

[0863] ##STR00539##

[0864] To a stirred solution of dimethylphosphine oxide (117 mg, 1.496 mmol) and 1-bromo-5-fluoro-4-iodo-2-methoxybenzene (450 mg, 1.360 mmol) in 1,4-dioxane (1 mL) were added XantPhos (79 mg, 0.136 mmol), Pd.sub.2(dba).sub.3 (62 mg, 0.068 mmol) and K.sub.3PO.sub.4 (433 mg, 2.040 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (4-bromo-2-fluoro-5-methoxyphenyl)dimethylphosphine oxide (110 mg, 37%) as a white solid. MS ESI calculated for C.sub.9H.sub.11BrFO.sub.2P [M+H].sup.+, 280.97 282.97, found 281.00 283.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.49-7.41 (m, 1H), 7.40-7.34 (m, 1H), 3.96 (s, 3H), 1.83 (s, 3H), 1.80 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?115.46. .sup.31P NMR (162 MHz, Chloroform-d) ? 32.07.

Example 130: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-5-fluoro-2-methoxyphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0865] ##STR00540##

[0866] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and (4-bromo-2-fluoro-5-methoxyphenyl)dimethylphosphine oxide (35 mg, 0.124 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 21% B to 36% B in 10 min; Wave Length: 254/220 nm) to afford (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-5-fluoro-2-methoxyphenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (54 mg, 77%) as a white solid. MS ESI calculated for C.sub.29H.sub.22D.sub.3F.sub.3N.sub.3O.sub.4P [M+H].sup.+, 559.17, found 559.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.3, 1.3 Hz, 1H), 7.83-7.75 (m, 2H), 7.57-7.49 (m, 1H), 7.46-7.38 (m, 2H), 7.30 (d, J=8.2 Hz, 1H), 7.14-7.07 (m, 1H), 6.79 (t, J=72.9 Hz, 1H), 6.30 (d, J=7.1 Hz, 1H), 5.04 (d, J=7.0 Hz, 1H), 3.87 (s, 3H), 3.55-3.43 (m, 1H), 2.90 (d, J=13.5 Hz, 1H), 1.86 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.05, ?80.50, ?80.62, ?81.07, ?116.71, ?116.72. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.91, 30.88.

Example 131: (7R,14R)-11-(3-amino-4-(dimethylphosphoryl)-5-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0867] ##STR00541## ##STR00542##

Preparation 131A: (2-amino-4-bromo-6-fluorophenyl)dimethylphosphine oxide

[0868] ##STR00543##

[0869] To a stirred solution of dimethylphosphine oxide (272 mg, 3.482 mmol) and 5-bromo-3-fluoro-2-iodoaniline (1.00 g, 3.165 mmol) in 1,4-dioxane (10 mL) were added XantPhos (183 mg, 0.317 mmol), Pd.sub.2(dba).sub.3 (145 mg, 0.158 mmol) and K.sub.3PO.sub.4 (1.01 g, 4.748 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (2-amino-4-bromo-6-fluorophenyl)dimethylphosphine oxide (250 mg, 29%) as a yellow solid. MS ESI calculated for C.sub.8H.sub.10BrFNOP [M+H].sup.+, 265.97 267.97, found 266.00 268.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 6.80 (d, J=2.2 Hz, 1H), 6.35-6.26 (m, 1H), 3.62 (s, 2H), 1.90 (d, J=3.6 Hz, 3H), 1.87 (d, J=3.6 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?98.61. .sup.31P NMR (162 MHz, Chloroform-d) ? 34.88.

Example 131: (7R,14R)-11-(3-amino-4-(dimethylphosphoryl)-5-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0870] ##STR00544##

[0871] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.124 mmol) and (2-amino-4-bromo-6-fluorophenyl)dimethylphosphine oxide (40 mg, 0.149 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (10 mg, 0.012 mmol) and K.sub.3PO.sub.4 (79 mg, 0.372 mmol) at room temperature. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 15% B to 20% B in 10 min; Wave Length: 254/220 nm) to afford (7R,14R)-11-(3-amino-4-(dimethylphosphoryl)-5-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (35 mg, 52%) as a white solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 544.17, found 544.05. .sup.1H NMR (400 MHz, DMSO-d.sub.6) ? 8.27 (d, J=7.9 Hz, 1H), 7.78-7.55 (m, 2H), 7.51-7.36 (m, 3H), 7.16 (d, J=8.4 Hz, 1H), 6.38-6.30 (m, 1H), 6.21 (d, J=7.2 Hz, 2H), 6.04 (s, 2H), 5.22 (d, J=7.1 Hz, 1H), 3.60-3.47 (m, 1H), 2.80 (d, J=13.8 Hz, 1H), 1.37-0.76 (m, 6H). .sup.19F NMR (377 MHz, DMSO-d.sub.6) ? ?79.39, ?79.85, ?81.81, ?83.43, ?83.88, ?102.07. .sup.31P NMR (162 MHz, DMSO-d.sub.6) ? 28.63.

Example 132: (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-6-fluoro-4-methylpyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0872] ##STR00545## ##STR00546##

Preparation 132A: 6-chloro-2-fluoro-4-methylpyridin-3-amine

[0873] ##STR00547##

[0874] A solution of 2-fluoro-4-methylpyridin-3-amine (10.00 g, 79.281 mmol) and NCS (11.64 g, 87.209 mmol) in ACN (200 mL) was stirred for 3 h at room temperature. The reaction was quenched by the addition of water (50 mL) at room temperature. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?300 mL). The combined organic layers were washed with brine (3?300 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (4/1) to afford 6-chloro-2-fluoro-4-methylpyridin-3-amine (10.91 g, 86%) as an orange solid. MS ESI calculated for C.sub.6H.sub.6ClFN.sub.2 [M+H].sup.+, 161.02, found 160.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 6.92 (s, 1H), 3.61 (s, 2H), 2.21 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?87.75.

Preparation 132B: 6-chloro-2-fluoro-3-iodo-4-methylpyridine

[0875] ##STR00548##

[0876] A solution of 6-chloro-2-fluoro-4-methylpyridin-3-amine (8.00 g, 49.819 mmol) in conc. H.sub.2SO.sub.4 (132 mL) was stirred for 10 min at room temperature. To the above mixture was added NaNO.sub.2 (3.61 g, 52.310 mmol) at 0? C. The resulting mixture was stirred for additional 1 h at room temperature. To a stirred solution of KI (8.7 g, 52.310 mmol) in H.sub.2O (103 mL) was added above solution dropwise at 0? C. The resulting mixture was stirred for 2 h at room temperature. The resulting mixture was extracted with EtOAc (3?200 mL). The combined organic layers were washed with brine (3?300 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (5/1) to afford 6-chloro-2-fluoro-3-iodo-4-methylpyridine (5.13 g, 38%) as a light yellow liquid. MS ESI calculated for C.sub.6H.sub.4ClFIN [M+H].sup.+, 271.91, found 271.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.11 (s, 1H), 2.48 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?52.37.

Preparation 132C: 3-(1-aminoethyl)-1-methylpyridin-2-one

[0877] ##STR00549##

[0878] To a stirred solution of 6-chloro-2-fluoro-3-iodo-4-methylpyridine (1.00 g, 3.684 mmol) and (methylphosphonoyl)methane (316 mg, 4.052 mmol) in 1,4-dioxane (10 mL) were added Pd.sub.2(dba).sub.3 (337 mg, 0.368 mmol), XantPhos (426 mg, 0.737 mmol) and K.sub.3PO.sub.4 (1.6 g, 7.368 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 100? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 6-chloro-3-(dimethylphosphoryl)-2-fluoro-4-methylpyridine (450 mg, 55%) as a red solid. MS ESI calculated for C.sub.8H.sub.10ClFNOP [M+H].sup.+, 222.02, found 221.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.16 (s, 1H), 2.83 (s, 3H), 1.89 (s, 3H), 1.85 (s, 3H).

Example 132: (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-6-fluoro-4-methylpyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0879] ##STR00550##

[0880] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.165 mmol) and 6-chloro-3-(dimethylphosphoryl)-2-fluoro-4-methylpyridine (55 mg, 0.247 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2 (13 mg, 0.017 mmol) and K.sub.3PO.sub.4 (105 mg, 0.495 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with DCM/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions: Column: C18 Column 120 g; Mobile Phase A: water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: CH.sub.3CN; Flow rate: 60 mL/min; Gradient: 30% B to 70% B in 20 min; 254/220 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(5-(dimethylphosphoryl)-6-fluoro-4-methylpyridin-2-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (58 mg, 64%) as a white solid. MS ESI calculated for C.sub.27H.sub.21D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 544.17, found 544.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.48 (d, J=8.2 Hz, 1H), 8.22 (s, 1H), 7.93 (d, J=8.6 Hz, 1H), 7.78 (d, J=8.6 Hz, 1H), 7.54 (s, 1H), 7.42 (t, J=8.2 Hz, 1H), 7.32 (d, J=8.1 Hz, 1H), 6.96 (t, J=72.8 Hz, 1H), 6.33 (d, J=7.1 Hz, 1H), 4.99 (d, J=7.0 Hz, 1H), 3.54-3.42 (m, 1H), 2.91 (d, J=8.8 Hz, 4H), 1.92 (s, 3H), 1.88 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?55.75, ?55.79, ?80.07, ?80.52, ?80.97, ?81.42. .sup.31P NMR (162 MHz, Chloroform-d) 36.01.

Example 133: 5-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)-2-(dimethylphosphoryl)-3-fluorobenzonitrile

[0881] ##STR00551## ##STR00552##

Preparation 133A: 2-amino-5-bromo-3-fluorobenzonitrile

[0882] ##STR00553##

[0883] A solution of 2-amino-3-fluorobenzonitrile (3.00 g, 22.038 mmol) and NBS (3.92 g, 22.038 mmol) in DCM (60 mL) was stirred for 3 h at room temperature. The reaction was quenched by the addition of sat. sodium thiosulfate (aq.) (50 mL) at 0? C. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?150 mL). The combined organic layers were washed with brine (2?100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford 2-amino-5-bromo-3-fluorobenzonitrile (4.60 g, 98%) as purple solid. MS ESI calculated for C.sub.7H.sub.4BrFN.sub.2 [M?H].sup.?, 212.95 214.95, found 212.75 214.75. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.35-7.29 (m, 2H), 4.53 (s, 2H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?129.90.

Preparation 133B: 5-bromo-3-fluoro-2-iodobenzonitrile

[0884] ##STR00554##

[0885] To a stirred solution of 2-amino-5-bromo-3-fluorobenzonitrile (4.77 g, 22.183 mmol) and CH.sub.2I.sub.2 (29.71 g, 110.915 mmol) in ACN (100 mL) was added tert-butyl nitrite (4.58 g, 44.366 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at 0? C. and then for 2 h at 50? C. The mixture was allowed to cool down to room temperature and concentrated under reduce pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (3:1) to afford 5-bromo-3-fluoro-2-iodobenzonitrile (410 mg, 6%) as pink solid. MS ESI calculated for C.sub.7H.sub.2BrFIN [M+H].sup.+, 325.84 327.84, found N/A. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.58 (s, 1H), 7.47-7.40 (m, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?85.09.

Preparation 133C: 5-bromo-2-(dimethylphosphoryl)-3-fluorobenzonitrile

[0886] ##STR00555##

[0887] To a stirred solution of 5-bromo-3-fluoro-2-iodobenzonitrile (280 mg, 0.859 mmol) and dimethylphosphine oxide (81 mg, 1.031 mmol) in 1,4-dioxane (3 mL) were added K.sub.3PO.sub.4 (219 mg, 1.031 mmol), XantPhos (50 mg, 0.086 mmol) and Pd.sub.2(dba).sub.3 (39 mg, 0.043 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 60? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford 5-bromo-2-(dimethylphosphoryl)-3-fluorobenzonitrile (35 mg, 15%) as a white solid. MS ESI calculated for C.sub.9H.sub.8BrFNOP [M+H].sup.+, 275.95 277.95, found 275.85 277.85. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.85 (s, 1H), 7.63-7.52 (m, 1H), 1.93 (d, J=2.1 Hz, 3H), 1.90 (d, J=2.1 Hz, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?98.56. .sup.31P NMR (162 MHz, Chloroform-d) ? 31.63.

Example 133: 5-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)-2-(dimethylphosphoryl)-3-fluorobenzonitrile

[0888] ##STR00556##

[0889] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (61 mg, 0.127 mmol) and 5-bromo-2-(dimethylphosphoryl)-3-fluorobenzonitrile (35 mg, 0.127 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (81 mg, 0.381 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (21 mg, 0.025 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 18% B to 33% B in 10 min; Wave Length: 254/220 nm) to afford 5-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)-2-(dimethylphosphoryl)-3-fluorobenzonitrile (34 mg, 45%) as a white solid. MS ESI calculated for C.sub.28H.sub.19D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 554.16, found 554.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.2 Hz, 1H), 7.90 (d, J=1.8 Hz, 1H), 7.86 (d, J=8.6 Hz, 1H), 7.76 (s, JH), 7.59-7.43 (m, 3H), 7.34 (d, J=8.2 Hz, 1H), 6.92 (t, J=72.9 Hz, 1H), 6.34 (d, J=7.1 Hz, 1H), 5.08 (d, J=7.0 Hz, 1H), 3.59-3.47 (m, 1H), 2.94 (d, J=13.6 Hz, 1H), 1.98 (s, 3H), 1.94 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.38, ?80.83, ?81.18, ?81.63, ?100.05. .sup.31P NMR (162 MHz, Chloroform-d) ? 31.63.

Example 134: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0890] ##STR00557##

Preparation 134: (5-bromo-3-methylpyridin-2-yl)dimethylphosphine oxide

[0891] ##STR00558##

[0892] A mixture of 5-bromo-2-iodo-3-methylpyridine (500 mg, 1.678 mmol), (methylphosphonoyl)methane (137 mg, 1.762 mmol), XantPhos (97 mg, 0.168 mmol), Pd.sub.2(dba).sub.3 (154 mg, 0.168 mmol) and K.sub.3PO.sub.4 (1.10 g, 5.034 mmol) in 1,4-dioxane (5 mL) was stirred for overnight at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (0.1% FA), 5% to 35% gradient in 20 min; detector, 254 nm. This resulted in (5-bromo-3-methylpyridin-2-yl)dimethylphosphine oxide (280 mg, 67%) as a colorless oil. MS ESI calculated for C.sub.8H.sub.11BrNOP [M+H].sup.+, 247.98 249.98, found 247.80 249.75. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.56 (s, 1H), 7.74-7.68 (m, 1H), 2.73 (s, 3H), 1.81 (s, 3H), 1.78 (s, 3H). .sup.31P NMR (162 MHz, Chloroform-d) ? 42.57.

Example 134: (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0893] ##STR00559##

[0894] A mixture of (7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 0.103 mmol), (5-bromo-3-methylpyridin-2-yl)dimethylphosphine oxide (31 mg, 0.124 mmol), K.sub.2CO.sub.3 (28 mg, 0.206 mmol) and Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (8 mg, 0.010 mmol) in 1,4-dioxane (0.9 mL) and H.sub.2O (0.1 mL) was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0?10%) followed by reversed-phase flash chromatography with the following conditions, column, C18 silica gel, mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 20% to 45% gradient in 20 min; detector, 254 nm to afford (7R,14R)-1-(difluoromethoxy)-11-(6-(dimethylphosphoryl)-5-methylpyridin-3-yl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (38 mg, 69%) as a white solid. MS ESI calculated for C.sub.27H.sub.22D.sub.3F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 526.18, found 526.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.73 (d, J=2.1 Hz, 1H), 8.57-8.45 (m, 1H), 7.85 (d, J=8.5 Hz, 1H), 7.76 (d, J=1.7 Hz, 1H), 7.74-7.69 (m, 1H), 7.56-7.52 (m, 1H), 7.45 (t, J=8.2 Hz, 1H), 7.37-7.29 (m, 1H), 6.87 (t, J=72.8 Hz, 1H), 6.35 (d, J=7.1 Hz, 1H), 5.10 (d, J=7.1 Hz, 1H), 3.57-3.47 (m, 1H), 2.93 (d, J=13.7 Hz, 1H), 2.84 (s, 3H), 1.88 (s, 3H), 1.85 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.34, ?80.78, ?80.84, ?81.28. .sup.31P NMR (162 MHz, Chloroform-d) ? 41.63.

Example 135: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0895] ##STR00560## ##STR00561##

Preparation 135A: tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-{[(S)-2-methylpropane-2-sulfinyl]amino}propanoate

[0896] ##STR00562##

[0897] A mixture of Zn powder (36.92 g, 564.635 mmol) and CuCl (11.18 g, 112.927 mmol) in THF (400 mL) was stirred for 2 h at 60? C. under nitrogen atmosphere. The mixture was allowed to cool down to room temperature. To the above mixture was added tert-butyl 2-bromoacetate (55.07 g, 282.317 mmol) dropwise over 15 min at 25? C. The resulting mixture was stirred for additional 2 h at 60? C. The mixture was allowed to cool down to room temperature again. To the above mixture was added a solution of (S)N-{[2-bromo-6-(difluoromethoxy)phenyl]methylidene}-2-methylpropane-2-sulfinamide (40.00 g, 112.927 mmol) in THF (40 mL) dropwise over 15 min at 10? C. The resulting mixture was stirred for additional 3 h at room temperature. The resulting mixture was filtered, the filter cake was washed with MTBE (3?100 mL). To the above filtrate were added MTBE (200 mL) and saturated citric acid solution (500 mL). The aqueous layer was extracted with MTBE (2?500 mL) and the combined organic layers were washed with saturated NaHCO.sub.3 solution (500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. This resulted in tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-{[(S)-2-methylpropane-2-sulfinyl]amino}propanoate (51.00 g, 96%) as a yellow oil. MS ESI calculated for C.sub.18H.sub.26BrF.sub.2NO.sub.4S [M+H].sup.+, 470.07 472.07, found 470.05 472.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.50-7.38 (m, 1H), 7.15 (t, J=8.1 Hz, 1H), 7.10-6.98 (m, 1H), 6.81-6.39 (m, 1H), 5.62-5.49 (m, 1H), 4.34-4.11 (m, 1H), 3.29-3.07 (m, 1H), 3.06-2.82 (m, 1H), 1.33 (s, 9H), 1.12 (s, 9H).

Preparation 135B: tert-butyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate

[0898] ##STR00563##

[0899] To a stirred solution of tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-{[(S)-2-methylpropane-2-sulfinyl]amino}propanoate (51.00 g, 108.425 mmol) in THF (500 mL) and H.sub.2O (100 mL) was added I.sub.2 (5.50 g, 21.685 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for overnight at 50? C. The reaction was quenched by the addition of sat. NaHCO.sub.3 (aq.) (1 L) at 0? C. The resulting mixture was extracted with EtOAc (3?800 mL). The combined organic layers were washed with brine (1 L), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford the crude product. The crude product (48 g) was dissolved in ACN (320 mL), (2S)-2-hydroxy-2-phenylacetic acid (16.50 g, 108.425 mmol) in ACN (80 mL) was added to above solution at room temperature. The resulting mixture was stirred for additional 15 min at room temperature. The precipitated solids were collected by filtration and washed with ACN (50 mL). To the above solids was added CH.sub.2Cl.sub.2 (500 mL) and sat. NaHCO.sub.3 (aq.) (500 mL). The mixture was stirred for additional 15 min at room temperature and extracted with CH.sub.2Cl.sub.2 (3?300 mL). The combined organic layers were washed with brine (400 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford tert-butyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate (29.00 g, 73%, ee>98%) as a colorless oil. MS ESI calculated for C.sub.14H.sub.18BrF.sub.2NO.sub.3 [M+H].sup.+, 366.04 368.04, found 366.05 368.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.46-7.38 (m, 1H), 7.16-7.01 (m, 2H), 6.83-6.42 (m, 1H), 5.06-4.97 (m, 1H), 2.98-2.86 (m, 1H), 2.82-2.70 (m, 1H), 1.38 (d, J=1.9 Hz, 9H).

Preparation 135C: tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propanoate

[0900] ##STR00564##

[0901] A solution of tert-butyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate (17.00 g, 46.422 mmol), TEA (9.7 mL, 69.633 mmol) and 5-chloro-1,3-difluoro-2-nitrobenzene (11.14 g, 57.563 mmol) in ACN (300 mL) was stirred for overnight at room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (5/1) to afford tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propanoate (25 g, 99%) as a dark yellow oil. MS ESI calculated for C.sub.20H.sub.19BrClF.sub.3N.sub.2O.sub.5 [M+H].sup.+ 539.01 541.01, found 538.90 540.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.06 (d, J=8.9 Hz, 1H), 7.49-7.34 (m, 1H), 7.23-7.17 (m, 1H), 7.16-7.13 (m, 1H), 6.83 (d, J=6.2 Hz, 1H), 6.65 (t, J=73.2 Hz, 1H), 6.50-6.32 (m, 1H), 5.78-5.56 (m, 1H), 3.25-2.92 (m, 1H), 2.87-2.64 (m, 1H), 1.40 (s, 9H).

Preparation 135D: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propanal

[0902] ##STR00565##

[0903] To a stirred solution of tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propanoate (26.00 g, 48.172 mmol) in DCM (350 mL) was added DIBAL-H (53 mL, 52.989 mmol, 1M in THF) dropwise at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 3 h at ?78? C. under nitrogen atmosphere. The reaction was quenched with 1M HCl (aq.) at ?78? C. The resulting mixture was extracted with DCM (3?300 mL). The combined organic layers were washed with brine (3?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford the crude (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propanal (23.00 g) as a yellow oil. MS ESI calculated for C.sub.16H.sub.11BrClF.sub.3N.sub.2O.sub.4 [M+H].sup.+ 466.95 468.95, found 466.90 468.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.79 (s, 1H), 8.03 (d, J=9.1 Hz, 1H), 7.50-7.42 (m, 1H), 7.21-7.18 (m, 1H), 7.16-7.14 (m, 1H), 6.89-6.83 (m, 1H), 6.69 (t, J=76.0 Hz, 1H), 6.51-6.45 (m, 1H), 5.89-5.78 (m, 1H), 3.50-3.37 (m, 1H), 3.15-2.90 (m, 1H).

Preparation 135E: (R)N-[(1E,3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propylidene]-2-methylpropane-2-sulfinamide

[0904] ##STR00566##

[0905] To a stirred solution of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propanal (23.00 g, 49.185 mmol) and (R)-2-methylpropane-2-sulfinamide (6.56 g, 54.104 mmol) in DCM (230 mL) was added Cs.sub.2CO.sub.3 (16.03 g, 49.185 mmol) at room temperature. The resulting mixture was stirred for 6 h at room temperature under nitrogen atmosphere. The resulting mixture was diluted with H.sub.2O (300 mL) and extracted with DCM (3?300 mL). The combined organic layers were washed with brine (3?200 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure to afford the crude (R)N-[(1E,3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propylidene]-2-methylpropane-2-sulfinamide (26.00 g, 92%) as an orange red oil. MS ESI calculated for C.sub.20H.sub.20BrClF.sub.3N.sub.3O.sub.4S [M+Na].sup.+, 592.00 594.00, found 591.95 573.90.

Preparation 135F: (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]-1-cyanopropyl]-2-methylpropane-2-sulfinamide

[0906] ##STR00567##

[0907] To a stirred solution of (R)N-[(1E,3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]propylidene]-2-methylpropane-2-sulfinamide (26.00 g, 45.549 mmol) and CsF (13.84 g, 91.110 mmol) in THF (260 mL) was added TMSCN (9.04 g, 91.098 mmol) at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for overnight at room temperature under nitrogen atmosphere. The reaction was quenched with sat. NaHCO.sub.3 (aq.) at room temperature and extracted with EtOAc (3?300 mL). The combined organic layers were washed with brine (3?200 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (1/1) to afford (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]-1-cyanopropyl]-2-methylpropane-2-sulfinamide (5.40 g, 19%) as a yellow solid. MS ESI calculated for C.sub.21H.sub.21BrClF.sub.3N.sub.4O.sub.4S [M+H].sup.+, 597.01 599.01 found 597.00 599.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.13-7.79 (m, 1H), 7.47 (d, J=7.9 Hz, 1H), 7.25-7.07 (m, 2H), 6.94-6.58 (m, 2H), 6.58-6.40 (m, 1H), 5.66-5.40 (m, 1H), 4.38-4.25 (m, 1H), 4.12-4.05 (m, 1H), 2.91-2.65 (m, J H), 2.53-2.27 (m, 1H), 1.32-1.11 (m, 9H).

Preparation 135G: (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-9-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine

[0908] ##STR00568##

[0909] A mixture of TiCl.sub.3 (65.55 g, 72.264 mmol, 17% in HCl) and EtOH (40 mL) was stirred for 5 min at 75? C. under nitrogen atmosphere. To the above mixture was added a solution of (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(5-chloro-3-fluoro-2-nitrophenyl)amino]-1-cyanopropyl]-2-methylpropane-2-sulfinamide (5.40 g, 9.033 mmol) in EtOH (20 mL) dropwise over 10 min at ?78? C. The resulting mixture was stirred for additional 5 h at 80? C. The mixture was allowed to cool down to room temperature and concentrated under vacuum and then basified to pH-9 with saturated Na.sub.2CO.sub.3 (aq.). The mixture was extracted with EtOAc (3?150 mL). The combined organic layers were washed with brine (300 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (19/1) to afford (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-9-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (3.10 g, 74%) as a brown solid. MS ESI calculated for C.sub.17H.sub.12BrClF.sub.3N.sub.3O [M+H].sup.+ 445.98 447.98, found 445.95 447.95.

Preparation 135H: (7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0910] ##STR00569##

[0911] To a solution of (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-9-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (2.80 g, 6.269 mmol), PCy.sub.3.Math.HBF.sub.4 (461 mg, 1.254 mmol), pyridine-2-carboxylic acid (385 mg, 3.135 mmol), K.sub.2CO.sub.3 (4.33 g, 31.345 mmol) in 1,4-dioxane (100 mL) was added Pd(OAc).sub.2 (211 mg, 0.940 mmol) in a pressure tank. The mixture was purged with nitrogen for 3 min and then was pressurized to 10 atm. with carbon monoxide at 120? C. for overnight. The reaction mixture was cooled to room temperature and filtered to remove insoluble solids. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/EA (1/5) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (1.30 g, 52%) as a light grey solid. MS ESI calculated for C.sub.18H.sub.11ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+ 394.05, found 393.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.48-8.40 (m, 1H), 7.58 (d, J=6.5 Hz, 1H), 7.48 (t, J=8.2 Hz, 1H), 7.44-7.38 (m, 1H), 7.29 (d, J=1.7 Hz, 1H), 7.06-7.00 (m, 1H), 6.76 (t, J=72.5 Hz, 1H), 6.35 (d, J=7.1 Hz, 1H), 5.18 (t, J=6.5 Hz, 1H), 3.63-3.48 (m, 1H), 2.89 (d, J=13.4 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.42, ?80.86, ?81.06, ?81.50, ?123.85.

Preparation 1351: (7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0912] ##STR00570##

[0913] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (150 mg, 0.381 mmol) in THF (4 mL) was added KHMDS (0.5 mL, 0.457 mmol, 1 M in THF) dropwise at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 30 min at ?78? C. under nitrogen atmosphere. To the above mixture was added a solution of iodomethane-d.sub.3 (72 mg, 0.495 mmol) in THF (0.5 mL) dropwise at ?78? C. The resulting mixture was stirred for additional overnight at room temperature. The reaction was quenched with 0.5 mL sat. NH.sub.4Cl (aq.) at room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (150 mg, 95%) as a light brown solid. MS ESI calculated for C.sub.19H.sub.10D.sub.3ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 411.08, found 410.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.44 (m, 1H), 7.45 (t, J=8.2 Hz, 1H), 7.37-7.31 (m, 1H), 7.27 (d, J=1.8 Hz, 1H), 7.01-6.94 (m, 1H), 6.74 (t, J=72.6 Hz, 1H), 6.21 (d, J=7.2 Hz, 1H), 4.97 (d, J=7.1 Hz, 1H), 3.56-3.40 (m, 1H), 2.88 (d, J=13.6 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.19, ?80.64, ?81.07, ?81.51, ?124.37.

Example 135: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0914] ##STR00571##

[0915] To a solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (130 mg, 0.316 mmol) and 2-[4-(dimethylphosphoryl)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (122 mg, 0.411 mmol) in 1,4-dioxane (5 mL) and H.sub.2O (1 mL) were added SPhos (12 mg, 0.032 mmol), SPhos Pd Gen.3 (24 mg, 0.032 mmol) and K.sub.3PO.sub.4 (201 mg, 0.948 mmol). After stirring for 3 h at 80? C. under a nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure and purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (12/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 35% to 80% gradient in 25 min; detector, 254 nm to afford ((7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-9-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (113 mg, 64%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.1 Hz, 1H), 8.08-7.95 (m, 1H), 7.58-7.48 (m, 2H), 7.47-7.39 (m, 1H), 7.34-7.27 (m, 2H), 7.21 (d, J=11.5 Hz, 1H), 7.05-6.64 (m, 1H), 6.30 (d, J=7.0 Hz, 1H), 5.02 (d, J=6.9 Hz, 1H), 3.63-3.41 (m, 1H), 2.91 (d, J=13.5 Hz, 1H), 1.85 (s, 3H), 1.82 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.37, ?80.82, ?80.89, ?81.34, ?105.50, ?125.70. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.73.

Example 136: Dimethyl (4-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)-2-fluorobenzyl)phosphonate

[0916] ##STR00572##

Preparation 136A: (7R,14R)-1-(difluoromethoxy)-11-(3-fluoro-4-(hydroxymethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0917] ##STR00573##

[0918] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (150 mg, 0.382 mmol) and (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (144 mg, 0.573 mmol) in 1,4-dioxane (1.6 mL) and H.sub.2O (0.4 mL) were added SPhos (31 mg, 0.076 mmol), SPhos Pd Gen.3 (60 mg, 0.076 mmol) and K.sub.2CO.sub.3 (158 mg, 1.146 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (7R,14R)-1-(difluoromethoxy)-11-(3-fluoro-4-(hydroxymethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (180 mg, 97%) as a brown solid. MS ESI calculated for C.sub.26H.sub.17D.sub.3F.sub.3N.sub.3O.sub.3 [M+H].sup.+, 483.16, found 483.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.46 (m, 1H), 7.76 (d, J=8.5 Hz, 1H), 7.68 (d, J=1.8 Hz, 1H), 7.53-7.35 (m, 4H), 7.33-7.28 (m, 2H), 6.84 (t, J=72.9 Hz, 1H), 6.28 (d, J=7.2 Hz, 1H), 4.96 (d, J=7.1 Hz, 1H), 4.81 (s, 2H), 3.48-3.43 (m, 1H), 2.88 (d, J=13.6 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.22, ?80.66, ?80.80, ?81.25, ?119.53.

Preparation 136B: (7R,14R)-11-(4-(chloromethyl)-3-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0919] ##STR00574##

[0920] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(3-fluoro-4-(hydroxymethyl)phenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (180 mg, 0.373 mmol) in Toluene (2 mL) was added SOCl.sub.2 (0.3 mL, 3.730 mmol) dropwise at 0? C. under nitrogen atmosphere. The resulting mixture was stirred for 3 h at 80? C. The resulting mixture was concentrated under vacuum. This result in (7R,14R)-11-(4-(chloromethyl)-3-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (180 mg, 96%) as a yellow solid. MS ESI calculated for C.sub.26H.sub.16D.sub.3ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 501.13, found 501.15. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.53 (d, J=8.2 Hz, 1H), 7.84-7.81 (m, 1H), 7.61 (d, J=8.2 Hz, 1H), 7.57-7.50 (m, 2H), 7.44-7.30 (m, 2H), 7.24 (s, 1H), 7.17 (d, J=8.0 Hz, 1H), 6.91 (t, J=72.4 Hz, 1H), 6.58-6.50 (m, 1H), 5.82-5.65 (m, 1H), 4.69 (s, 2H), 3.96-3.78 (m, 1H), 3.09-2.96 (m, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.55, ?81.00, ?81.30, ?81.75, ?116.31.

Example 136: dimethyl (4-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)-2-fluorobenzyl)phosphonate

[0921] ##STR00575##

[0922] A mixture of (7R,14R)-11-(4-(chloromethyl)-3-fluorophenyl)-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.120 mmol) in trimethyl phosphite (1 mL) was stirred for 16 h at 110? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (0.1% FA), 30% to 60% gradient in 20 min; detector, 254/220 nm to afford dimethyl (4-((7R,14R)-1-(difluoromethoxy)-6-(methyl-d3)-5-oxo-5,6,7,14-tetrahydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-11-yl)-2-fluorobenzyl)phosphonate (21 mg, 31%) as a white solid. MS ESI calculated for C.sub.28H.sub.22D.sub.3F.sub.3N.sub.3O.sub.5P [M+H].sup.+, 575.17, found 575.30. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50 (d, J=8.3 Hz, 1H), 7.79 (d, J=8.5 Hz, 1H), 7.70 (s, 1H), 7.53-7.48 (m, 1H), 7.47-7.40 (m, 2H), 7.37-7.30 (m, 2H), 7.28 (s, 1H), 6.86 (t, J=72.8 Hz, 1H), 6.32 (d, J=6.7 Hz, 1H), 5.09 (d, J=6.5 Hz, 1H), 3.77 (s, 3H), 3.74 (s, 3H), 3.57-3.45 (m, 1H), 3.26 (d, J=21.6 Hz, 2H), 2.91 (d, J=13.3 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.39, ?80.83, ?80.93, ?81.38, ?116.99. .sup.31P NMR (162 MHz, Chloroform-d) ? 27.72.

Example 137: (7R,14R)-11-(6-(diethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0923] ##STR00576##

[0924] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.128 mmol) and (5-bromopyridin-2-yl)diethylphosphine oxide (41 mg, 0.154 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (11 mg, 0.013 mmol) and K.sub.3PO.sub.4 (82 mg, 0.384 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum and purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 16% B to 31% B in 10 min; Wave Length: 254/220 nm) to afford (7R,14R)-11-(6-(diethylphosphoryl)pyridin-3-yl)-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (16 mg, 23%) as a white solid. MS ESI calculated for C.sub.27H.sub.25F.sub.2N.sub.4O.sub.3P [M+H].sup.+, 523.16, found 523.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.01-8.90 (m, 1H), 8.49-8.39 (m, 1H), 8.26-8.17 (m, 1H), 8.05-7.95 (m, 1H), 7.93-7.79 (m, 2H), 7.73 (d, J=1.7 Hz, 1H), 7.58-7.36 (m, 3H), 6.88 (t, J=72.7 Hz, 1H), 6.41 (d, J=7.2 Hz, 1H), 5.07 (t, J=6.9 Hz, 1H), 3.60-3.46 (m, 1H), 2.91 (d, J=13.4 Hz, 1H), 2.14-2.02 (m, 4H), 1.25-1.06 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.43, ?80.67, ?80.88, ?81.34. .sup.31P NMR (162 MHz, Chloroform-d) ? 45.75.

Example 138: (7R,14R)-11-(4-(diethylphosphoryl)-2-fluorophenyl)-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0925] ##STR00577##

Preparation 138A: (4-bromo-3-fluorophenyl)diethylphosphine oxide

[0926] ##STR00578##

[0927] To a stirred solution of 1-bromo-2-fluoro-4-iodobenzene (300 mg, 0.997 mmol) and diethylphosphine oxide (116 mg, 1.097 mmol) in 1,4-dioxane (4 mL) were added Pd.sub.2(dba).sub.3 (91 mg, 0.100 mmol), XantPhos (58 mg, 0.100 mmol) and K.sub.3PO.sub.4 (423 mg, 1.994 mmol) at room temperature. The resulting mixture was stirred for overnight at 90? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) to afford (4-bromo-3-fluorophenyl)diethylphosphine oxide (230 mg, 82%) as a yellow solid. MS ESI calculated for C.sub.10H.sub.13BrFOP [M+H].sup.+, 278.99 280.99, found 279.05 281.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 7.70 (t, 1H), 7.47 (t, J=9.5 Hz, 1H), 7.35 (t, J=9.0 Hz, 1H), 2.11-1.96 (m, 2H), 1.95-1.81 (m, 2H), 1.20-1.07 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?105.16. .sup.31P NMR (162 MHz, Chloroform-d) ? 43.71.

Example 138: (7R,14R)-11-(4-(diethylphosphoryl)-2-fluorophenyl)-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0928] ##STR00579##

[0929] To a stirred solution of (7R,14R)-1-(difluoromethoxy)-11-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.128 mmol) and (4-bromo-3-fluorophenyl)diethylphosphine oxide (43 mg, 0.154 mmol) in 1,4-dioxane (0.8 mL) and H.sub.2O (0.2 mL) were added Pd(dppf)Cl.sub.2.Math.CH.sub.2Cl.sub.2 (11 mg, 0.013 mmol) and K.sub.3PO.sub.4 (82 mg, 0.384 mmol) at room temperature. The resulting mixture was stirred for 2 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under vacuum and purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (0% to 10%) followed by Prep-HPLC with the following conditions (Column: XBridge Prep Phenyl OBD Column 19*250 mm, 5 m; Mobile Phase A: Water (10 mmol/L NH.sub.4HCO.sub.3), Mobile Phase B: ACN; Flow rate: 60 mL/min; Gradient: 20% B to 35% B in 10 min; Wave Length: 254/220 nm) to afford (7R,14R)-11-(4-(diethylphosphoryl)-2-fluorophenyl)-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (35 mg, 51%) as a white solid. MS ESI calculated for C.sub.28H.sub.25F.sub.3N.sub.3O.sub.3P [M+H].sup.+, 540.16, found 540.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.48-8.39 (m, 1H), 7.83 (d, J=8.5 Hz, 1H), 7.75 (s, 1H), 7.63-7.34 (m, 7H), 6.83 (t, J=72.6 Hz, 1H), 6.41 (d, J=7.1 Hz, 1H), 5.10 (t, J=6.6 Hz, 1H), 3.58-3.44 (m, 1H), 2.90 (d, J=13.3 Hz, 1H), 2.16-1.94 (m, 4H), 1.24-1.06 (m, 6H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.17, ?80.61, ?81.24, ?81.68, ?116.89. .sup.31P NMR (162 MHz, Chloroform-d) ? 43.01.

Example 139: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0930] ##STR00580## ##STR00581##

Preparation 139A: tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propanoate

[0931] ##STR00582##

[0932] A solution of tert-butyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate (35.00 g, 95.575 mmol), 1-chloro-2,3-difluoro-4-nitrobenzene (22.20 g, 114.690 mmol) and TEA (14.51 g, 143.363 mmol) in ACN (350 mL) was stirred for 3 h at 50? C. The resulting mixture was concentrated under reduced pressure and purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/PE (10/1) to afford tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propanoate (48.20 g, 93%) as a yellow oil. MS ESI calculated for C.sub.20H.sub.19BrClF.sub.3N.sub.2O.sub.5 [M+H].sup.+, 539.01 541.01, found 539.05 541.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.51-8.37 (m, 1H), 7.89 (d, J=9.3 Hz, 1H), 7.44 (d, J=7.0 Hz, 1H), 7.19-7.09 (m, 2H), 6.84-6.45 (m, 2H), 6.17-6.07 (m, 1H), 3.12-2.97 (mi, 1H), 2.87-2.76 (m, 1H), 1.34 (s, 9H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?80.14, ?80.60, ?80.94, ?81.38, ?123.07.

Preparation 139B: (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propanal

[0933] ##STR00583##

[0934] To a stirred solution of tert-butyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propanoate (31.00 g, 57.436 mmol) in DCM (465 mL) was added DIBAL-H (63.0 mL, 63.180 mmol) dropwise at ?78? C. The resulting mixture was stirred for 3 h at ?78? C. under nitrogen atmosphere. The reaction was quenched with HCl (1N) at ?78? C. The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?500 mL). The combined organic layers were washed with brine (3?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/PE (1/1) to afford (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propanal (23.80 g, 88%) as a yellow oil. MS ESI calculated for C.sub.16H.sub.11BrClF.sub.3N.sub.2O.sub.4 [M+H].sup.+, 466.95 468.95, found 466.80 468.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.82 (s, 1H), 8.39 (d, J=9.0 Hz, 1H), 7.93-7.84 (m, 1H), 7.46-7.40 (m, 1H), 7.19-7.09 (m, 2H), 6.88-6.47 (m, 2H), 6.34-6.24 (m, 1H), 3.44-3.30 (m, 1H), 3.10-2.98 (m, 1H).

Preparation 139C: (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propylidene]-2-methylpropane-2-sulfinamide

[0935] ##STR00584##

[0936] A solution of (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propanal (23.80 g, 50.896 mmol), (R)-2-methylpropane-2-sulfinamide (12.34 g, 101.792 mmol) and Ti(Oi-Pr).sub.4 (28.93 g, 101.792 mmol) in DCM (240 mL) was stirred for 2 h at room temperature. The resulting mixture was diluted with water (200 mL). The resulting mixture was extracted with CH.sub.2Cl.sub.2 (3?300 mL). The combined organic layers were washed with brine (3?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/PE (1/1) to afford (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propylidene]-2-methylpropane-2-sulfinamide (24.10 g, 82%) as a yellow oil. MS ESI calculated for C.sub.20H.sub.20BrClF.sub.3N.sub.3O.sub.4S [M?H].sup.?, 568.00 570.00, found 567.80 569.80. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47 (d, J=8.0 Hz, 1H), 8.12 (t, J=3.9 Hz, 1H), 7.89 (d, J=9.3 Hz, 1H), 7.44 (d, J=7.5 Hz, 1H), 7.21-7.09 (m, 2H), 6.85-6.44 (m, 2H), 6.30-6.15 (m, 1H), 3.54-3.29 (m, 1H), 3.17-3.03 (m, 1H), 1.11 (s, 9H).

Preparation 139D: (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]-1-cyanopropyl]-2-methylpropane-2-sulfinamide

[0937] ##STR00585##

[0938] A solution of (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]propylidene]-2-methylpropane-2-sulfinamide (24.00 g, 42.046 mmol), CsF (12.77 g, 84.092 mmol) and TMSCN (8.34 g, 84.092 mmol) in THF (240 mL) was stirred for 16 h at room temperature. The reaction was quenched with sat. NaHCO.sub.3 (aq.) at room temperature. The resulting mixture was extracted with EtOAc (3?300 mL). The combined organic layers were washed with brine (3?500 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with PE/EA (1/1) to afford (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]-1-cyanopropyl]-2-methylpropane-2-sulfinamide (21.10 g, 84%) as a yellow solid. MS ESI calculated for C.sub.21H.sub.21BrClF.sub.3N.sub.4O.sub.4S [M+H].sup.+, 597.01 599.01, found 597.05 599.05.

Preparation 139E: (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-12-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine

[0939] ##STR00586##

[0940] To a stirred solution of TiCl.sub.3 (58.96 g, 66.912 mmol, 17% in HCl) in EtOH (65 mL) was added (R)N-[(3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(3-chloro-2-fluoro-6-nitrophenyl)amino]-1-cyanopropyl]-2-methylpropane-2-sulfinamide (5.00 g, 8.364 mmol) in EtOH (35 mL) dropwise at 75? C. The resulting mixture was stirred for 2 h at 75? C. The resulting mixture was concentrated under vacuum. The residue was basified to pH 9 with Na.sub.2CO.sub.3. The resulting mixture was extracted with EtOAc (3?100 mL). The combined organic layers were washed with brine (3?200 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (15/1) to afford (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-12-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (3.08 g, 82%) as a yellow solid. MS ESI calculated for C.sub.17H.sub.12BrClF.sub.3N.sub.3O [M+H].sup.+, 445.98 447.98, found 446.05 448.05.

Preparation 139F: (7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0941] ##STR00587##

[0942] To a solution of (3R,5R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-11-chloro-12-fluoro-2,7-diazatricyclo[6.4.0.0{circumflex over ()}{2,6}]dodeca-1(8),6,9,11-tetraen-5-amine (2.80 g, 6.269 mmol) in 1,4-dioxane (100 mL) was added PCy.sub.3.Math.HBF.sub.4 (461 mg, 1.254 mmol), pyridine-2-carboxylic acid (386 mg, 3.135 mmol), Pd(OAc).sub.2 (141 mg, 0.627 mmol) and K.sub.2CO.sub.3 (4.33 g, 31.345 mmol) in a pressure tank. The mixture was purged with nitrogen for 2 min and then was pressurized to 10 atm. with carbon monoxide at 110? C. for 16 h. The reaction mixture was cooled to room temperature. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford ((7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (850 mg, 34%) as a yellow solid. MS ESI calculated for C.sub.18H.sub.11ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 394.05, found 394.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.47-8.36 (m, 1H), 7.97 (d, J=6.2 Hz, 1H), 7.48-7.36 (m, 3H), 7.23-7.14 (m, 1H), 6.96-6.52 (m, 2H), 4.95 (t, J=6.4 Hz, 1H), 3.57-3.34 (m, 1H), 2.84 (d, J=13.3 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?78.59, ?79.03, ?82.55, ?82.58, ?83.00, ?83.02, ?134.02.

Preparation 139G: (7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0943] ##STR00588##

[0944] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (550 mg, 1.397 mmol) in THF (15 mL) was added KHMDS (2.0 mL, 1.676 mmol, 1 M in THF) dropwise at 0? C. The resulting mixture was stirred for 1 h at 0? C. under nitrogen atmosphere. To the above mixture was added iodomethane-d.sub.3 (263 mg, 1.816 mmol) at room temperature. The resulting mixture was stirred for additional 2 h at room temperature. The reaction was quenched with sat. NH.sub.4Cl (aq.) at room temperature. The resulting mixture was extracted with EtOAc (3?50 mL). The combined organic layers were washed with brine (3?100 mL), dried over anhydrous Na.sub.2SO.sub.4. After filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (460 mg, 80%) as a light yellow solid. MS ESI calculated for C.sub.19H.sub.10D.sub.3ClF.sub.3N.sub.3O.sub.2 [M+H].sup.+, 411.08, found 411.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.43 (d, J=8.0 Hz, 1H), 7.51-7.34 (m, 3H), 7.23-7.13 (m, 1H), 6.96-6.54 (m, 1H), 6.47 (d, J=7.4 Hz, 1H), 4.92 (d, J=7.0 Hz, 1H), 3.51-3.36 (m, 1H), 2.85 (d, J=13.7 Hz, 1H).

Example 139: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0945] ##STR00589##

[0946] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (80 mg, 0.195 mmol) and 2-[4-(dimethylphosphoryl)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (87 mg, 0.292 mmol) in 1,4-dioxane (1 mL) and H.sub.2O (0.2 mL) were added SPhos (8 mg, 0.020 mmol 8), SPhos Pd Gen.3 (8 mg, 0.010 mmol) and K.sub.3PO.sub.4 (83 mg, 0.390 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 1 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure and purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in water (10 mmol/L NH.sub.4HCO.sub.3), 30% to 70% gradient in 20 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-12-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (61 mg, 57%) as a white solid. MS ESI calculated for C.sub.27H.sub.19D.sub.3F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 547.15, found 547.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.48-8.39 (m, 1H), 8.09-7.98 (m, 1H), 7.61 (d, J=8.5 Hz, 1H), 7.52-7.41 (m, 2H), 7.39-7.27 (m, 3H), 6.92-6.49 (m, 2H), 5.05 (d, J=6.7 Hz, 1H), 3.57-3.44 (m, 1H), 2.90 (d, J=13.5 Hz, 1H), 1.86 (s, 3H), 1.82 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?79.15, ?79.60, ?82.36, ?82.78, ?105.78, ?136.56. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.43.

Example 140:(7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-12-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0947] ##STR00590##

[0948] To a stirred solution of (7R,14R)-11-chloro-1-(difluoromethoxy)-12-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (60 mg, 0.20 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.4 mL) were added SPhos Pd G3 (12 mg, 0.0016 mmol), SPhos (12 mg, 0.030 mmol) and K.sub.3PO.sub.4 (96 mg, 0.46 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. under nitrogen atmosphere. The resulting mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10/1) followed by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (20 mmol/L NH.sub.4HCO.sub.3), 30% to 50% gradient in 20 min. This resulted in ((7R,14R)-1-(difluoromethoxy)-1144-(dimethylphosphoryl)-3-fluorophenyl)-12-fluoro-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (30 mg, 35%) as a white solid. MS ESI calculated for C.sub.26H.sub.20F.sub.4N.sub.3O.sub.3P [M+H].sup.+, 530.12, found 530.05.

Example 141: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0949] ##STR00591##

Preparation 141A: tert-butyl (R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propanoate

[0950] ##STR00592##

[0951] To a stirred mixture of tert-butyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate (5.00 g, 13.654 mmol) and 2,6-dichloro-3-nitropyridine (3.43 g, 17.750 mmol) in DCM (50 mL) was added TEA (2.85 mL, 20.481 mmol) at room temperature. The resulting mixture was stirred for 16 h at room temperature. The resulting mixture was concentrated under reduced pressure and purified by silica gel column chromatography, eluted with PE/DCM (1:1) to afford tert-butyl (R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propanoate (6.50 g, 91%) as a yellow oil. MS ESI calculated for C.sub.19H.sub.19BrClF.sub.2N.sub.1O.sub.5 [M+H].sup.+, 522.02 524.02, found 522.05 524.05. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.16 (d, J=8.5 Hz, J H), 8.31 (d, J=8.6 Hz, 1H), 7.46-7.38 (m, 1H), 7.18-7.10 (m, 2H), 6.91-6.68 (m, 1H), 6.61 (d, J=8.6 Hz, 1H), 6.59-6.51 (m, 1H), 3.17-3.05 (m, 1H), 2.90-2.79 (m, 1H), 1.36 (s, 9H).

Preparation 141B: (R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propanal

[0952] ##STR00593##

[0953] To a stirred mixture of tert-butyl (R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propanoate (6.50 g, 12.435 mmol) in DCM (97 mL) was added 1 M of DIBAL-H in THF (13.68 mL, 13.679 mmol) at ?78? C. under nitrogen atmosphere. The resulting mixture was stirred for 3 h at ?78? C. under nitrogen atmosphere. The reaction was quenched with water at ?78? C. The resulting mixture was filtered, the filter cake was washed with DCM (3?100 mL). The filtrate was extracted with CH.sub.2Cl.sub.2 (3?200 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (5:1) to afford (R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propanal (5.00 g, 89%) as a yellow oil. MS ESI calculated for C.sub.15H.sub.11BrClF.sub.2N.sub.3O.sub.4 [M+H].sup.+, 449.96 451.96, found 449.90 451.90. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.82 (s, 1H), 9.17 (d, J=8.7 Hz, 1H), 8.33 (d, J=8.5 Hz, 1H), 7.52-7.44 (m, 1H), 7.23-7.07 (m, 2H), 6.95-6.54 (m, 3H), 3.43-3.28 (m, 1H), 3.16-2.98 (m, 1H).

Preparation 141C: (R)N((R,E)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propylidene)-2-methylpropane-2-sulfinamide

[0954] ##STR00594##

[0955] To a stirred mixture of (R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propanal (5.80 g, 12.871 mmol) and (R)-2-methylpropane-2-sulfinamide (1.87 g, 15.445 mmol) in DCM (59 mL) was added Ti(Oi-Pr).sub.4 (5.49 g, 19.306 mmol) at room temperature. The resulting mixture was stirred for 16 h at room temperature. The reaction was quenched with water at room temperature. The resulting mixture was filtered, the filter cake was washed with DCM (3?50 mL). The filtrate was extracted with CH.sub.2Cl.sub.2 (3?200 mL). The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (5:1) to afford (R)N((R,E)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propylidene)-2-methylpropane-2-sulfinamide (5.00 g, 70%) as a yellow oil. MS ESI calculated for C.sub.19H.sub.20BrClF.sub.2N.sub.4O.sub.4S [M+H].sup.+, 553.00 555.00, found 552.95 554.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.18 (d, J=8.6 Hz, 1H), 8.33-8.28 (m, 1H), 8.12-8.06 (m, 1H), 7.47-7.41 (m, 1H), 7.19-7.05 (m, 2H), 6.93-6.50 (m, 3H), 3.55-3.39 (m, 1H), 3.14-3.05 (m, 1H), 1.12 (s, 9H).

Preparation 141D: (R)N-((3R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)-1-cyanopropyl)-2-methylpropane-2-sulfinamide

[0956] ##STR00595##

[0957] To a stirred mixture of (R)N((R,E)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)propylidene)-2-methylpropane-2-sulfinamide (4.50 g, 8.126 mmol) and CsF (2.47 g, 16.252 mmol) in THF (45 mL) was added TMSCN (1.61 g, 16.252 mmol) at 0? C. The resulting mixture was stirred for 2 h at room temperature under nitrogen atmosphere. The reaction was quenched with water at room temperature. The aqueous layer was extracted with CH.sub.2Cl.sub.2 (3?100 mL). The combined organic layer was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with PE/EA (1:1) to afford (R)N-((3R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)-1-cyanopropyl)-2-methylpropane-2-sulfinamide (4.50 g, 95%) as a yellow oil. MS ESI calculated for C.sub.20H.sub.21BrClF.sub.2N.sub.5O.sub.4S [M+H].sup.+, 580.02 582.01, found 580.00 582.00. .sup.1H NMR (400 MHz, Chloroform-d) ? 9.46-9.05 (m, 1H), 8.40-8.31 (m, 1H), 7.48-7.41 (m, 1H), 7.22-7.11 (m, 2H), 6.83-6.74 (m, 1H), 6.71-6.65 (m, J H), 6.56-6.44 (m, 1H), 4.35-4.25 (m, 1H), 4.18 (d, J=9.2 Hz, 1H), 2.91-2.72 (m, 1H), 2.48-2.37 (m, 1H), 1.27 (s, 9H).

Preparation 141E: (6R,8R)-8-(2-bromo-6-(difluoromethoxy)phenyl)-2-chloro-7,8-dihydro-6H-pyrrolo[2,1:2,3]imidazo[4,5-b]pyridin-6-amine

[0958] ##STR00596##

[0959] To a stirred mixture of (R)N-((3R)-3-(2-bromo-6-(difluoromethoxy)phenyl)-3-((6-chloro-3-nitropyridin-2-yl)amino)-1-cyanopropyl)-2-methylpropane-2-sulfinamide (4.50 g, 7.748 mmol) in EtOH (45 mL) was added TiCl.sub.3 in 15?20% HCl (47.79 g, 6.888 mmol) at room temperature. The resulting mixture was stirred for 16 h at 80? C. The resulting mixture was diluted with EtOAc (100 mL). The residue was basified to pH 7 with saturated NaHCO.sub.3 (aq.). The resulting mixture was filtered, the filter cake was washed with EtOAc (3?100 mL). The filtrate was washed with 2?100 mL of water. The organic layer was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (6R,8R)-8-(2-bromo-6-(difluoromethoxy)phenyl)-2-chloro-7,8-dihydro-6H-pyrrolo[2,1:2,3]imidazo[4,5-b]pyridin-6-amine (2.00 g, 60/6) as a colorless oil. MS ESI calculated for C.sub.16H.sub.12BrClF.sub.2N.sub.4O [M+H].sup.+, 428.99 430.99, found 428.90 430.90.

Preparation 141F: (7R,14R)-11-chloro-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0960] ##STR00597##

[0961] To a stirred mixture of (6R,8R)-8-(2-bromo-6-(difluoromethoxy)phenyl)-2-chloro-7,8-dihydro-6H-pyrrolo[2,1:2,3]imidazo[4,5-b]pyridin-6-amine (250 mg, 0.582 mmol) and K.sub.2CO.sub.3 (160 mg, 1.164 mmol) in 1,4-dioxane (10 mL) were added XantPhos (34 mg, 0.058 mmol) and Pd(OAc).sub.2 (13 mg, 0.058 mmol) at room temperature under carbon monoxide atmosphere. The resulting mixture was stirred for 16 h at 100? C. under carbon monoxide atmosphere. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (50 mg, 23%) as a yellow solid. MS ESI calculated for C.sub.17H.sub.11ClF.sub.2N.sub.4O.sub.2 [M+H].sup.+, 377.05, found 376.95. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.44-8.37 (m, 1H), 7.94 (d, J=8.5 Hz, 1H), 7.56-7.39 (m, 2H), 7.34-7.27 (m, 1H), 7.23-6.93 (m, 2H), 6.55 (d, J=7.4 Hz, 1H), 4.94 (t, J=6.6 Hz, 1H), 3.56-3.37 (m, 1H), 2.87 (d, J=13.4 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?76.51, ?76.96, ?82.32, ?82.76.

Preparation 141G: (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0962] ##STR00598##

[0963] To a stirred mixture of (7,14R)-11-chloro-1-(difluoromethoxy)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (500 mg, 1.327 mmol) in THF (2.5 mL) was added 1M KHMDS in THF (1.73 mL, 1.725 mmol) at ?78? C. The resulting mixture was stirred for 1 h at ?78? C. under nitrogen atmosphere. To the above mixture was added CD.sub.3I (385 mg, 2.654 mmol) at ?78? C. The resulting mixture was stirred for additional 16 h at room temperature. The resulting mixture was quenched with 2 drops water and concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) to afford (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (400 mg, 77%) as a yellow solid. MS ESI calculated for C.sub.18H.sub.10D.sub.3ClF.sub.2N.sub.4O.sub.2 [M+H].sup.+, 394.09, found 394.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.50-8.44 (m, 1H), 7.97-7.89 (m, 1H), 7.48-7.39 (m, 2H), 7.24-6.89 (m, 2H), 6.50-6.45 (m, 1H), 5.05-4.97 (m, 1H), 3.53-3.38 (m, 1H), 2.89 (d, J=13.7 Hz, 1H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?76.87, ?77.31, ?82.27, ?82.71.

Example 141: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0964] ##STR00599##

[0965] To a stirred mixture of (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (65 mg, 0.166 mmol) and 2-[4-(dimethylphosphoryl)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (80 mg, 0.266 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (106 mg, 0.498 mmol), Sphos Pd Gen.3 (13 mg, 0.017 mmol) and Sphos (7 mg, 0.017 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) following by reversed-phase flash chromatography with the following conditions: column, C18 silica gel; mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (57 mg, 65%) as a white solid. MS ESI calculated for C.sub.26H.sub.19D.sub.3F.sub.3N.sub.4O.sub.3P [M+H].sup.+, 530.16, found 530.20. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.52-8.40 (m, 1H), 8.10-8.00 (m, 2H), 7.94-7.89 (m, 1H), 7.84-7.75 (m, 1H), 7.69 (d, J=8.4 Hz, 1H), 7.44-7.35 (m, 2H), 7.32-6.88 (m, 1H), 6.55 (d, J=7.2 Hz, 1H), 5.00 (d, J=7.0 Hz, 1H), 3.58-3.39 (m, 1H), 2.91 (d, J=13.6 Hz, 1H), 1.87 (s, 3H), 1.83 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?78.12, ?78.56, ?81.58, ?82.03, ?105.87. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.69.

Example 142: (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one

[0966] ##STR00600##

[0967] To a stirred mixture of (7R,14R)-11-chloro-1-(difluoromethoxy)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (65 mg, 0.166 mmol) and 2-[4-(dimethylphosphoryl)-2,5-difluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (85 mg, 0.266 mmol) in 1,4-dioxane (2 mL) and H.sub.2O (0.2 mL) were added K.sub.3PO.sub.4 (106 mg, 0.498 mmol), Sphos Pd Gen.3 (13 mg, 0.017 mmol) and Sphos (7 mg, 0.017 mmol) at room temperature under nitrogen atmosphere. The resulting mixture was stirred for 16 h at 80? C. The resulting mixture was concentrated under vacuum. The residue was purified by silica gel column chromatography, eluted with CH.sub.2Cl.sub.2/MeOH (10:1) following by reversed-phase flash chromatography with the following conditions: column, C18 silica gel, mobile phase, CH.sub.3CN in Water (10 mmol/L NH.sub.4HCO.sub.3), 25% to 55% gradient in 25 min; detector, 254 nm. This resulted in (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-2,5-difluorophenyl)-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]pyrido[3,2:4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one (44 mg, 48%) as a white solid. MS ESI calculated for C.sub.26H.sub.18D.sub.3F.sub.4N.sub.4O.sub.3P [M+H].sup.+, 548.15, found 548.10. .sup.1H NMR (400 MHz, Chloroform-d) ? 8.54-8.43 (m, 1H), 8.12-8.04 (m, 1H), 7.92-7.65 (m, 3H), 7.45-7.35 (m, 2H), 7.30-6.86 (m, 1H), 6.53 (d, J=7.3 Hz, 1H), 5.00 (d, J=7.1 Hz, 1H), 3.59-3.43 (m, 1H), 2.91 (d, J=13.6 Hz, 1H), 1.88 (s, 3H), 1.84 (s, 3H). .sup.19F NMR (377 MHz, Chloroform-d) ? ?78.19, ?78.63, ?81.70, ?82.14, ?112.16, ?120.27. .sup.31P NMR (162 MHz, Chloroform-d) ? 30.14.

[0968] II. Biological Evaluation

[0969] TNF? Induced HEK Blue Cellular Assay

[0970] Test articles were diluted in DMSO and serially diluted into 384 well assay plate (Corning 3765), at final concentrations ranging from 30 mM to 0.5 nM. HEK Blue? TNF? reporter cells were added at a final density of 10,000 cell per well in assay media [DMEM (Gibco, cat #21063-029), 10% fetal bovine serum (ExcelBio, cat #FND500), 1% Penicillin-Streptomycin (Solarbio, cat #P1400-100]. TNF? (R&D 210-TA-020/CF) was then added to the assay plate at a final concentration of 100 ?g/ml. This plate was then incubated for 24 hrs at 37? C. and 5% CO.sub.2. Secreted alkaline phosphatase expression was then measured using QUANTI-Blue? (Invivogen), according to manufacturer instructions and read on an Envision microplate reader at 620 nm.

[0971] Inhibition data for test compound over a range of concentration was plotted as percentage inhibition of the test compound (100%=maximum inhibition). IC.sub.50 values were determined after correcting for background [(sample read-mean of low control)/(mean of high control-mean of low control)] where by the low control is DMSO without stimulation and high control is DMSO with stimulation. The IC.sub.50 is defined as the concentration of test compound which produces 50% inhibition and was quantified using the 4 parameter logistic equation to fit the data.

[0972] Representative data for exemplary compounds is presented in Table 3.

TABLE-US-00003 TABLE 3 Ex. No IC.sub.50 value 1 B 2 A 3 B 4 A 5 A 6 A 7 A 8 B 9 B 10 A 11 C 12 C 13 A 14 A 15 A 16 A 17 A 18 A 19 A 20 A 21 B 22 A 23 A 24 A 25 A 26 A 27 A 28 A 29 A 30 A 31 A 32 A 33 A 34 A 35 B 36 A 37 A 38 A 39 A 40 B 41 A 42 A 43 A 44 A 45 A 46 A 47 A 48 A 49 A 50 A 51 A 52 A 53 A 54 A 55 A 56 A 57 A 58 A 59 A 60 A 61 A 62 A 63 A 64 B 65 A 66 A 67 A 68 A 69 A 70 A 71 D 72 A 73 A 74 B 75 A 76 A 77 A 78 A 79 A 80 A 81 A 82 B 83 A 84 A 85 A 86 A 87 B 88 A 89 D 90 A 91 A 92 A 93 A 94 A 95 A 96 B 97 A 98 A 99 A 100 A 101 A 102 A 103 A 104 B 105 A 106 A 107 A 108 A 109 A 110 A 111 A 112 A 113 A 114 A 115 A 116 A 117 A 118 A 119 A 120 A 121 B 122 B 123 B 124 A 125 A 126 A 127 A 128 A 129 A 130 A 131 D 132 A 133 A 134 A 135 A 136 A 137 A 138 A 139 A 140 A 141 A 142 A Note: IC.sub.50 data are designated within the following ranges: A: ?0.1 ?M B: >0.1 ?M to ?1.0 ?M C: >1.0 ?M to ?10 ?M D: >10 ?M to ?30 ?M

[0973] III. Preparation of Pharmaceutical Dosage Forms

Example 1: Oral Capsule

[0974] The active ingredient is a compound of Table 1, or a pharmaceutically acceptable salt or solvate thereof. A capsule for oral administration is prepared by mixing 1-1000 mg of active ingredient with starch or other suitable powder blend. The mixture is incorporated into an oral dosage unit such as a hard gelatin capsule, which is suitable for oral administration.

Example 2: Solution for Injection

[0975] The active ingredient is a compound of Table 1, or a pharmaceutically acceptable salt or solvate thereof, and is formulated as a solution in sesame oil at a concentration of 50 mg-eq/mL.

[0976] The examples and embodiments described herein are for illustrative purposes only and various modifications or changes suggested to persons skilled in the art are to be included within the spirit and purview of this application and scope of the appended claims.