TOOTH GEL AND TOOTH STRIP WITH REMINERALIZATION CAPABILITY AND PREPARATION METHOD OF TOOTH GEL

Abstract

The present application discloses a tooth gel and a tooth strip with remineralization capability, and a preparation method of the tooth gel. The tooth gel includes the following raw material components by mass: 1-35% of active ingredients, 20-60% of thickening agent, 20-70% of solvent, 5-25% of solid dispersant, 0.1-0.8% of essence, 0.1-1.0% of sweetener and 0.1-1.0% of pH regulator; the raw materials for preparing the active ingredients include calcium phosphate and/or bioactive glass; and the tooth strip includes a three-layer structure: an anti-sticking liner, a dental gel layer and a peel-off backing layer, where the anti-sticking liner is adhered to one surface of the dental gel layer, the other surface of the dental gel layer is adhered to the a peel-off backing layer, and the dental gel layer is a tooth gel.

Claims

1. A tooth gel with remineralization capability, comprising the following raw material components by mass: 1-35% of active ingredient; 20-60% of thickening agent; 20-70% of solvent; 5-25% of solid dispersant; 0.1-0.8% of essence; 0.1-1.0% of sweetener; 0.1-1.0% of pH regulator, the raw material for preparing the active ingredient comprises calcium phosphate, bioactive glass, or a combination thereof in any proportion.

2. The tooth gel with remineralization capability according to claim 1, wherein the raw material components further comprise, by mass, 0.1-1% of stabilizer.

3. The tooth gel with remineralization capability according to claim 1, wherein the calcium phosphate is amorphous calcium phosphate, casein phosphopeptide-calcium phosphate complex, brushite, octacalcium phosphate, ?-tricalcium phosphate, an apatite-like phase, or any combination thereof in any proportion; wherein the apatite-like phase is one or more of hydroxyapatite, fluorapatite, chlorapatite and composite apatite.

4. The tooth gel with remineralization capability according to claim 2, wherein the calcium phosphate is amorphous calcium phosphate, casein phosphopeptide-calcium phosphate complex, brushite, octacalcium phosphate, ?-tricalcium phosphate, an apatite-like phase, or any combination thereof in any proportion; wherein the apatite-like is one or more of hydroxyapatite, fluorapatite, chlorapatite and composite apatite.

5. The tooth gel with remineralization capability according to claim 1, wherein the raw material components of the bioactive glass comprise: SiO.sub.2, P.sub.2O.sub.5, and one or more selected from Li.sub.2O, Na.sub.2O, CaO, SrO, MgO, SnO, K.sub.2O, CaF.sub.2, SrF.sub.2, SrCl.sub.2, NaF, LaF.sub.3, KF, CaCl.sub.2), LaCl.sub.3, KCl, MgCl.sub.2, CuO and ZnO, and a content of P.sub.2O.sub.5 in the raw material components of the bioactive glass is more than 2.0 mol %; when a metal fluoride is contained, a total content of the metal fluoride in the raw material components of the bioactive glass is less than 9.3 mol %; the contents of the raw material components of the bioactive glass enable a network connectivity, NC of the bioactive glass to satisfy: 1.5?NC?3.2, wherein NC is calculated by a formula: $\mathrm{NC}=\left[4?M_{{\mathrm{SiO}}_2}-2?\left(M_{\mathrm{MO}}+M_{N_{2}O}\right)+6?M_{P_2{O}_5}\right]/M_{{\mathrm{SiO}}_2},$ and in the formula: $M_{{\mathrm{SiO}}_2}$ is a molar percentage content of SiO.sub.2 in the bioactive glass; M.sub.MO is a molar percentage content of alkaline earth metal oxide in the bioactive glass, $M_{N_{2}O}$ is a molar percentage content of alkali metal oxide in the bioactive glass, and $M_{P_2{O}_5}$ is a molar percentage content of P.sub.2O.sub.5 in the bioactive glass; and the bioactive glass is prepared by a high-temperature melting-cold quenching method.

6. The tooth gel with remineralization capability according to claim 5, wherein the raw material components of the bioactive glass comprise: SiO.sub.2, P.sub.2O.sub.5 and the following four classes of substances, wherein a first substance is an alkali metal or alkaline-earth metal oxide selected from at least one of Li.sub.2O, Na.sub.2O, CaO, SrO, MgO and K.sub.2O; a second substance is a fluoride selected from at least one of CaF.sub.2, SrF.sub.2, NaF, LaF.sub.3 and KF; a third substance is a chloride selected from at least one of SrCl.sub.2, CaCl.sub.2, LaCl.sub.3, KCl and MgCl.sub.2, and a fourth substance is a functional metal oxide selected from at least one of SnO, CuO and ZnO.

7. The tooth gel with remineralization capability according to claim 1, wherein the raw material components of the bioactive glass comprise: SiO.sub.2, P.sub.2O.sub.5, and one or more selected from Li.sub.2O, CaO, SrO, MgO, SnO, K.sub.2O, CaF.sub.2, SrF.sub.2, SrCl.sub.2, NaF, LaF.sub.3, KF, CaCl.sub.2), LaCl.sub.3, KCl, MgCl.sub.2, CuO and ZnO, and a content of P.sub.2O.sub.5 in the raw material components of the bioactive glass is more than 2.0 mol %; when a metal fluoride is contained, a total content of the metal fluoride in the raw material components of the bioactive glass is less than 9.3 mol %; the contents of the raw material components of the bioactive glass enable a network connectivity, NC of the bioactive glass to satisfy: 1.5?NC?3.2, wherein NC is calculated by a formula: $\mathrm{NC}=\left[4?M_{{\mathrm{SiO}}_2}-2?\left(M_{\mathrm{MO}}+M_{N_{2}O}\right)+6?M_{P_2{O}_5}\right]/M_{{\mathrm{SiO}}_2},$ and in the formula: $M_{{\mathrm{SiO}}_2}$ is a molar percentage content of SiO.sub.2 in the bioactive glass; M.sub.MO is a molar percentage content of alkaline earth metal oxide in the bioactive glass, $M_{N_{2}O}$ is a molar percentage content of alkali metal oxide in the bioactive glass, and $M_{p_2{O}_5}$ is a molar percentage content of P.sub.2O.sub.5 in the bioactive glass; and the bioactive glass is prepared by a high-temperature melting-cold quenching method.

8. The tooth gel with remineralization capability according to claim 7, wherein the raw material components of the bioactive glass comprise: SiO.sub.2, P.sub.2O.sub.5 and the following four classes of substances, wherein a first substance is an alkali metal or alkaline-earth metal selected from at least one of Li.sub.2O, CaO, SrO, MgO and K.sub.2O; a second substance is a fluoride selected from at least one of CaF.sub.2, SrF.sub.2, NaF, LaF.sub.3 and KF; a third substance is a chloride selected from at least one of SrCl.sub.2, CaCl.sub.2, LaCl.sub.3, KCl and MgCl.sub.2, and a fourth substance is a functional metal oxide selected from at least one of SnO, CuO and ZnO.

9. The tooth gel with remineralization capability according to claim 5, wherein when the raw material components of the bioactive glass comprise at least one of functional metal oxides SnO, CuO and ZnO, a content of each functional metal oxide in the raw material components of the bioactive glass is less than 5.0 mol %; and a content of P.sub.2O.sub.5 in the raw material components of the bioactive glass is more than 3.5 mol %; when the metal fluoride is contained, a total content of the metal fluoride in the raw material components of the bioactive glass is less than 6.0 mol %; the contents of the raw material components of the bioactive glass satisfy: $1.5?NC?2.4.$

10. The tooth gel with remineralization capability according to claim 7, wherein when the raw material components of the bioactive glass comprise at least one of functional metal oxides SnO, CuO and ZnO, a content of each functional metal oxide in the raw material components of the bioactive glass is less than 5.0 mol %; and a content of P.sub.2O.sub.5 in the raw material components of the bioactive glass is more than 3.5 mol %; when the metal fluoride is contained, a total content of the metal fluoride in the raw material components of the bioactive glass is less than 6.0 mol %; the contents of the raw material components of the bioactive glass satisfy: $1.5?NC?2.4.$

11. The tooth gel with remineralization capability according to claim 1, wherein the raw material for preparing the active ingredient further comprises one or more of desensitizer, whitening agent, antibacterial agent, and anti-caries ingredient.

12. The tooth gel with remineralization capability according to claim 11, wherein the desensitizer is one of potassium nitrate, oxalic acid, calcium oxalate, tea polyphenol, catechol, glyceryl linoleate and glyceryl oleate, or any combination thereof in any proportion; the whitening agent is one of carbamide peroxide, hydrogen peroxide and sodium hypochlorite, or any combination thereof in any proportion; the antibacterial agent is one of compound or complexes that release silver ions, copper ions, strontium ion, cobalt ions and zinc ions, or any combination thereof in any proportion; the anti-caries ingredient is one of fluorine-containing bioactive glass capable of releasing fluoride ions and soluble fluoride such as sodium fluoride, potassium fluoride, fluorine-containing ammonium salt, sodium monofluorophosphate, lanthanum, or any combination thereof in any proportion.

13. The tooth gel with remineralization capability according to claim 1, wherein the thickening agent is selected from one of sodium polyacrylate, cellulose, N-vinyl amide polymer, carbomer, sodium alginate, and gelatin, or from any combination thereof in any proportion; the solvent is selected from one of glycerol, absolute ethanol and water, or from any combination thereof in any proportion; the solid dispersant is selected from polyethylene glycol 400; the sweetener is selected from acesulfame potassium; the essence is selected from essence such as menthol; the pH regulator is selected from one of NaOH, KOH, NaHCO.sub.3 and H.sub.3PO.sub.4.

14. A tooth strip with remineralization capability, comprising a three-layer structure: an anti-sticking liner, a dental gel layer, and a peel-off backing layer, wherein the anti-sticking liner is adhered to one side of the dental gel layer, and the other side of the dental gel layer is adhered to the peel-off backing layer; and the dental gel layer is formed from the tooth gel with remineralization capability according to claim 1, and has a thickness of 100-300 um; the anti-sticking liner is selected from one of a polymer, a fabric and a film, one side of the anti-sticking liner is attached with a dental gel layer, and the other side of the anti-sticking liner is subjected to an anti-sticking treatment to prevent lips from being adhered; the peel-off backing layer is selected from one of a PET sheet, a foil, a plastic sheet and a paper sheet.

15. A method for preparing the tooth gel with remineralization capability according to claim 1, comprising the following steps: 1) accurately weighing each kind of raw materials based on a formula; 2) adding a thickening agent, a solid dispersant and active ingredient into a solvent, and performing homogeneous emulsification to obtain uniformly dispersed and completely mixed and dissolved materials; 3) keeping the material obtained in the step 2) at a temperature of 60? C., adding a stabilizer, an essence and a sweetener, and uniformly stirring; 4) slowly adding a pH regulator into the materials obtained in the step 3), and uniformly stirring; and 5) allowing the materials obtained in the step 4) to stand for 24 hours to obtain the tooth gel with remineralization capability.

16. The preparation method of the tooth gel with remineralization ability according to claim 15, wherein the uniformly stirring in step 3) comprises setting a rotation speed of a stirrer to 25-35 rpm and stirring for 10 minutes; in step 4), when a temperature of the materials obtained in the step 3) is reduced to 40-45? C., adding a whitening agent to prepare a whitening tooth gel or a tooth strip; the uniformly stirring in step 4) comprises setting a rotation speed of a stirrer to be 15-25 rpm, and stirring to obtain a uniform mixture.

Description

BRIEF DESCRIPTION OF DRAWINGS

[0057] These and/or other aspects and advantages of the present application will become more apparent and more readily appreciated from the following detailed description of embodiments of the present application taken in conjunction with the accompanying drawings, in which:

[0058] FIG. 1 is X-ray diffraction patterns of the products obtained after soaking a bioactive glass containing different contents of phosphorus in a buffer solution for one week, of which figure (a) belongs to low-phosphorus bioactive glass, and figure (b) belongs to high-phosphorus bioactive glass.

[0059] FIG. 2 is a scanning electron micrograph of the distribution of bioactive glass in a tooth strip with remineralization capability obtained in Example 1 of the present application.

[0060] FIG. 3 is a diagram showing the whitening efficacy of a tooth strip with remineralization capability obtained in Example 1 of the present application on in vitro model of stained-teeth caused by different substances, after 3 days, 7 days and 14 days of use, in which the substance in figure (a) is coffee, and the substance in figure (b) is black tea.

[0061] FIG. 4 is a diagram showing the whitening efficacy of the tooth strip with remineralization capability obtained in Example 2 of the present application on in vitro model of stained-teeth caused by (a) coffee and (b) black tea, after 3 days, 7 days and 14 days of use.

[0062] FIG. 5 is a diagram showing that the tooth strips obtained in Examples and Comparative Examples of the present application have equally good whitening efficacy after use.

[0063] FIG. 6 is a diagram showing the formation of a remineralization layer on the enamel surface of the in vitro teeth after 7 days of treatment with each of the tooth strips obtained in Example 1 and Comparative Example 1 of the present application.

[0064] FIG. 7 is a graph comparing the effects of the tooth strips of Examples and Comparative Example of the present application on coffee-stained enamel hardness.

[0065] FIG. 8 is a diagram showing the repair-remineralization capability of the tooth strips obtained in Example 3 and Comparative Example 1 of the present application.

[0066] FIG. 9 is a structural diagram of the tooth strip with remineralization capability obtained in Example 1 of the present application (in the figure: 1. peel-off backing layer; 2. dental gel layer; 3. anti-sticking liner).

DESCRIPTION OF EMBODIMENTS

[0067] The present application is further described in detail through embodiments, however, those embodiments should not be considered as a limitation of the present application.

Example 1

[0068] A tooth strip with remineralization capability was prepared by a three-layer structure: an anti-sticking liner, a dental gel layer, and a peel-off backing layer, where the anti-sticking liner was tightly adhered to one side of the dental gel layer, the dental gel layer had a thickness of 100 um, active ingredients were dispersed in the dental gel layer, and the other side of the dental gel layer was tightly adhered to the peel-off backing layer.

[0069] The anti-sticking liner was a transparent soft film adhesive attachment layer and was made from natural polymers.

[0070] The peel-off backing layer was a transparent film and was a sheet made from PET material.

[0071] The dental gel layer was a water-insoluble film layer and was prepared from the following components in percentage by mass: [0072] 35% of active ingredient; [0073] 20% of thickening agent; [0074] 25% of solvent; [0075] 19% of solid dispersant; [0076] 0.2% of essence; [0077] 0.3% of sweetener; [0078] 0.5% of pH regulator.

[0079] The active ingredient was prepared from a bioactive ingredient, a desensitizer, a whitening agent, an antibacterial agent and an anti-caries ingredient, with a mass ratio of 6:1:1:1:1.

[0080] The bioactive ingredient was a bioactive glass.

[0081] The bioactive glass was a bioactive glass-ceramic containing a small amount of crystalline phase in its matrix, and is prepared from SiO.sub.2, P.sub.2O.sub.5, CaF.sub.2, CaO and Na.sub.2O by a high-temperature melting cold-quenching (melt-quench) method, where P.sub.2O.sub.5 had a content of 5.5 mol %; a fluoride CaF.sub.2 was included in a content of 6.0 mol %; in addition, the contents of the components of the bioactive glass satisfied: NC is 2.0.

[0082] The desensitizer was an equal-mass mixture of potassium nitrate and glyceryl oleate.

[0083] The whitening agent was an equal-mass mixture of carbamide peroxide, hydrogen peroxide and hypochlorous acid.

[0084] The antibacterial agent was a mixture of compounds that can release silver ions and copper ions respectively, in a mass ratio of 1:2.

[0085] The anti-caries ingredient was a mixture of sodium fluoride, potassium fluoride, fluoride-containing ammonium salt, sodium monofluorophosphate and lanthanum fluoride in any proportion.

[0086] The thickening agent was selected from sodium polyacrylate.

[0087] The solvent was selected from a mixture of glycerol and absolute ethanol in equal volume.

[0088] The solid dispersant was selected from polyethylene glycol 400.

[0089] The sweetener was selected from acesulfame potassium.

[0090] The pH regulator was selected from NaOH.

[0091] A method for preparing the above mentioned tooth strip with remineralization capability included the following steps: [0092] 1) accurately weighing each kind of raw materials according to a proportion of components of the dental gel layer; [0093] 2) adding the weighed thickening agent, solid dispersant and active ingredients into a solvent, performing homogeneous emulsification in a stirrer until these components are uniformly dispersed, completely mixed and dissolved; [0094] 3) keeping the materials in the step 2) at a temperature of 60? C., adding a stabilizer and an essence, setting a rotation speed of the stirrer to be 30 rpm, and stirring for 10 minutes; [0095] 4) preparing a whitening tooth strip: adding a whitening agent when the temperature of the materials in the step 3) is reduced to 40-45? C.; [0096] 5) slowly adding a pH regulator into the above-mentioned materials, and simultaneously starting the stirrer and stirring at a rotation speed of 20 rpm until the materials are uniformly mixed; [0097] 6) allowing a mixture obtained in step 5) to stand for 24 hours, then inspecting, coating the qualified mixture uniformly on a plastic film, and laminating; [0098] 7) machine-cutting and molding the laminated semi-finished product according to the shape of the tooth strip, and packaging.

[0099] The use method of the tooth strip included tearing the tooth strip off from the peel-off backing layer, sticking one side of the dental gel layer on a buccal side of a dental crown, placing a long edge of the dental gel layer to be flush with a gingival margin, and gently pressing the tooth strip to make it fully adhered to the teeth for 30-60 minutes, tearing off the tooth strip, and gargling properly to clean the teeth as required.

[0100] The formula of the dental gel layer in this Example can be separately used or packaged as a tooth gel product. It was a gel-like gel, which was used in combination with a thermoset resin denture sheet, that was to say, the thermoset resin denture sheet was placed in hot water of 70-80? C. for 10-30 seconds to be softened and then taken out, and the softened denture sheet was sleeved on the teeth and pressed and shaped by a finger and removed; a proper amount of the tooth gel was introduced into the removed shaped denture sheet; and then the denture was put on and kept for 15-30 minutes and removed, and mouth was rinsed properly to clean the teeth as required. During use of the gel, it was not allowed for eating, drinking and smoking.

[0101] Similarly, the dental gel layer formula in other Examples can also be prepared according to the composition and contents of the formula to obtain a separate tooth gel product, which can be packaged as a commodity, or used in combination with an orthodontic denture, or used separately for minimally invasive tooth whitening, prevention of dental caries and prevention of periodontal disease.

Example 2

[0102] A tooth strip with remineralization capability, which was prepared by a three-layer structure: an anti-sticking liner, a dental gel layer, and a peel-off backing layer, where the anti-sticking liner was tightly adhered to one side of the dental gel layer, the dental gel layer had a thickness of 300 um, active ingredients were dispersed in the dental gel layer, and the other side of the dental gel layer was tightly adhered to the peel-off backing layer.

[0103] The anti-sticking liner was an opaque soft film adhesive attachment layer and was made from fabric.

[0104] The peel-off backing layer was a transparent film and was made from a foil of PET material.

[0105] The dental gel layer was a water-insoluble film layer and was prepared from the following components in percentage by mass: [0106] 20% of active ingredient; [0107] 41% of thickening agent; [0108] 20% of solvent; [0109] 17.8% of solid dispersant; [0110] 0.1% of essence; [0111] 1.0% of sweetener; [0112] 0.1% of pH regulator.

[0113] The active ingredient was prepared from a bioactive ingredient, a whitening agent, an antibacterial agent and an anti-caries ingredient, with a mass ratio of 6:1:1:2;

[0114] The bioactive ingredient was a bioactive glass.

[0115] The bioactive glass was an amorphous bioactive glass, and prepared from SiO.sub.2, P.sub.2O.sub.5, Li.sub.2O, SrO, MgO, SnO, SrF.sub.2, SrCl.sub.2 and KCl by a high-temperature melting cold-quenching (melt-quench) method, where P.sub.2O.sub.5 had a content of 4.0 mol %; a fluoride SrF.sub.2 was included in a content of 9.0 mol %; in addition, the contents of the components of the bioactive glass satisfied: NC is 2.4.

[0116] The whitening agent was hydrogen peroxide.

[0117] The antibacterial agent was a mixture of compounds that can release silver ions, copper ions and strontium ion respectively, in a mass ratio of 1:2:1.

[0118] The anti-caries ingredient was sodium fluoride.

[0119] The thickening agent was selected from cellulose.

[0120] The solvent was selected from a mixture of glycerol and water in a volume ratio of 1:2.

[0121] The solid dispersant was selected from polyethylene glycol 400.

[0122] The sweetener was selected from acesulfame potassium.

[0123] The pH regulator was selected from KOH.

[0124] A method for preparing the above mentioned tooth strip with remineralization capability included the following steps: [0125] 1) accurately weighing each kind of raw materials according to a proportion of components of the dental gel layer; [0126] 2) adding the weighed thickening agent, solid dispersant and active ingredients into a solvent, performing homogeneous emulsification in a stirrer until these components are uniformly dispersed, completely mixed and dissolved; [0127] 3) keeping the materials in the step 2) at a temperature of 60? C., adding a stabilizer and an essence, setting a rotation speed of the stirrer to be 30 rpm, and stirring for 10 minutes; [0128] 4) preparing a whitening tooth strip: adding a whitening agent when the temperature of the materials in the step 3) is reduced to 40-45? C.; [0129] 5) slowly adding a pH regulator into the above-mentioned materials, and simultaneously starting the stirrer and stirring at a rotation speed of 20 rpm until the materials are uniformly mixed; [0130] 6) allowing a mixture obtained in step 5) to stand for 24 hours, then inspecting, coating the qualified mixture uniformly on a plastic film, and laminating; [0131] 7) machine-cutting and molding the laminated semi-finished product according to the shape of the tooth strip, and packaging.

[0132] The use method of the tooth strip included tearing the tooth strip off from the peel-off backing layer, sticking one side of the dental gel layer on a buccal side of a dental crown, placing a long edge of the dental gel layer to be flush with a gingival margin, and gently pressing the tooth strip to make it fully adhered to the teeth for 30-60 minutes, tearing off the tooth strip, and gargling properly to clean the teeth as required.

Example 3

[0133] A tooth strip with remineralization capability was prepared by a three-layer structure: an anti-sticking liner, a dental gel layer, and a peel-off backing layer, where the anti-sticking liner was tightly adhered to one side of the dental gel layer, the dental gel layer had a thickness of 200 um, active ingredients were dispersed in the dental gel layer, and the other side of the dental gel layer was tightly adhered to the peel-off backing layer.

[0134] The anti-sticking liner was a transparent soft film adhesive attachment layer and was made from a film.

[0135] The peel-off backing layer was an opaque film and was made from paper of PET material.

[0136] The dental gel layer was a water-insoluble film layer and prepared from the following components in percentage by mass: [0137] 3.1% of active ingredient; [0138] 20% of thickening agent; [0139] 70% of solvent; [0140] 5% of solid dispersant; [0141] 0.6% of essence; [0142] 1.0% of sweetener; [0143] 0.3% of pH regulator.

[0144] The active ingredient was prepared from a bioactive ingredient, an antibacterial agent and an anti-caries ingredient, with a mass ratio of 6:1:1.

[0145] The bioactive ingredient was a bioactive glass.

[0146] The bioactive glass was a bioactive glass-ceramic containing a small amount of crystalline phase in its matrix, and was prepared from SiO.sub.2, P.sub.2O.sub.5, CaO, K.sub.2O, CuO and CaCl.sub.2 by a high-temperature melting cold-quenching (melt-quench) method, where P.sub.2O.sub.5 had a content of 2.5 mol %, and CuO had a content of 2.0 mol %; in addition, the contents of the components of the bioactive glass satisfied: NC is 3.2.

[0147] The antibacterial agent was a mixture of compounds that can release copper ions and strontium ions respectively in a mass ratio of 1:2.

[0148] The anti-caries ingredient was lanthanum fluoride.

[0149] The thickening agent was a mixture of N-vinyl amide polymer and sodium alginate in a mass ratio of 1:1.

[0150] The solvent was selected from glycerol.

[0151] The solid dispersant was selected from polyethylene glycol 400.

[0152] The sweetener was selected from acesulfame potassium.

[0153] The pH regulator was selected from NaHCO.sub.3.

[0154] A method for preparing the above mentioned tooth strip with remineralization capability included the following steps: [0155] 1) accurately weighing each kind of raw materials according to a proportion of components of the tooth strip; [0156] 2) adding the weighed thickening agent, solid dispersant and active ingredient into a solvent, and performing homogeneous emulsification in a stirrer until these components are uniformly dispersed, completely mixed and dissolved; [0157] 3) keeping the materials in the step 2) at a temperature of 60? C., adding a stabilizer and an essence, setting a rotation speed of the stirrer to be 30 rpm, and stirring for 10 minutes; [0158] 4) slowly adding a pH regulator into the above-mentioned materials, and simultaneously starting the stirrer and stirring at a rotation speed of 20 rpm until the materials are uniformly mixed; [0159] 5) allowing a mixture obtained in step 4) to stand for 24 hours, then inspecting, coating the qualified mixture uniformly on a plastic film, and laminating; [0160] 6) machine-cutting and molding the laminated semi-finished product according to the shape of the tooth strip, and packaging.

[0161] The use method of the tooth strip included tearing the tooth strip off from the peel-off backing layer, sticking one side of the dental gel layer on a buccal side of a dental crown, placing a long edge of the dental gel layer to be flush with a gingival margin, and gently pressing the tooth strip to make it fully adhered to the teeth for 30-60 minutes, tearing off the tooth strip, and gargling properly to clean the teeth as required.

Example 4

[0162] A tooth gel with remineralization capability was provided.

[0163] The tooth gel was prepared from the following components in percentage by mass: [0164] 15% of active ingredient; [0165] 30% of thickening agent; [0166] 32.7% of solvent; [0167] 20% of solid dispersant; [0168] 0.8% of essence; [0169] 0.5% of sweetener; [0170] 1.0% of pH regulator.

[0171] The active ingredient was prepared from a bioactive ingredient and a desensitizer, with a mass ratio of 6:1.

[0172] The bioactive glass was a casein phosphopeptide-calcium-phosphorus complex.

[0173] The desensitizer was an equal-mass mixture of oxalic acid, calcium oxalate, catechol, and glyceryl linoleate.

[0174] The thickening agent was selected from N-vinyl amides polymer.

[0175] The solvent was an equal-volume mixture of absolute ethanol and water.

[0176] The solid dispersant was selected from polyethylene glycol 400.

[0177] The sweetener was selected from acesulfame potassium.

[0178] The pH regulator was selected from NaHCO.sub.3.

[0179] A method for preparing the above mentioned tooth gel with remineralization capability included the following steps: [0180] 1) accurately weighing each kind of raw materials according to a proportion of components of the tooth gel; [0181] 2) adding the weighed thickening agent, solid dispersant and active ingredient into a solvent, and performing homogeneous emulsification in a stirrer until these components are uniformly dispersed, completely mixed and dissolved; [0182] 3) keeping the materials in the step 2) at a temperature of 60? C., adding a stabilizer and an essence, setting a rotation speed of the stirrer to be 30 rpm, and stirring for 10 minutes; [0183] 4) slowly adding a pH regulator into the above-mentioned materials, and simultaneously starting the stirrer and stirring at a rotation speed of 20 rpm until the materials are uniformly mixed; [0184] 5) sealing and packaging after the resulting product is inspected to be qualified.

[0185] The use method of the tooth gel included taking a proper amount of the tooth gel and evenly smearing it on the tooth surface to form a thin layer of tooth gel with a thickness of about 0.5 mm; taking a proper amount of matched anti-sticking liner film to cover an outer side of the tooth gel so as to prevent the tooth gel from being adhered to lips, keeping for 15-30 minutes; wiping or tearing off the thin layer of tooth gel, and gargling properly to clean the teeth as required. During use of the gel, it was not allowed for eating, drinking and smoking.

Example 5

[0186] A whitening tooth gel with remineralization capability was provided.

[0187] The tooth gel was prepared from the following components in percentage by mass: [0188] 1% of active ingredient; [0189] 60% of thickening agent; [0190] 26.7% of solvent; [0191] 10% of solid dispersant; [0192] 0.8% of essence; [0193] 0.5% of sweetener; [0194] 1.0% of pH regulator.

[0195] The active ingredient was a bioactive ingredient.

[0196] The bioactive ingredient was a mixture of amorphous calcium phosphate and a bioactive glass, with a mass ratio of 1:1.

[0197] The bioactive glass was a bioactive glass-ceramic containing a small amount of crystalline phase in its matrix, and was prepared from SiO.sub.2, P.sub.2O.sub.5, CaO, CaF.sub.2, K.sub.2O, ZnO and CaCl.sub.2 by a high-temperature melting cold-quenching (melt-quench) method, where P.sub.2O.sub.5 had a content of 2.5 mol %; a fluoride CaF.sub.2 was included in a content of 3.0 mol %; ZnO had a content of 4 mol %; in addition, the contents of the components of the bioactive glass satisfied: NC is 1.5.

[0198] The thickening agent was a mixture of carbomer and gelatin in a mass ratio of 2:1.

[0199] The solvent was an equal-volume mixture of absolute ethanol and water.

[0200] The solid dispersant was selected from polyethylene glycol 400.

[0201] The sweetener was selected from acesulfame potassium.

[0202] The pH regulator was selected from NaHCO.sub.3.

[0203] A method for preparing the above mentioned whitening tooth gel with remineralization capability included the following steps: [0204] 1) accurately weighing each kind of raw materials according to a proportion of components of the tooth gel; [0205] 2) adding the weighed thickening agent, solid dispersant and active ingredient into a solvent, and performing homogeneous emulsification in a stirrer until these components are uniformly dispersed, completely mixed and dissolved; [0206] 3) keeping the materials in the step 2) at a temperature of 60? C., adding a stabilizer and an essence, setting a rotation speed of the stirrer to be 30 rpm, and stirring for 10 minutes; [0207] 4) preparing a whitening tooth gel: adding a whitening agent when the temperature of the materials in the step 3) is reduced to 45? C.; [0208] 5) slowly adding a pH regulator into the above-mentioned materials, and simultaneously starting the stirrer and stirring at a rotation speed of 20 rpm until the materials are uniformly mixed; [0209] 6) sealing and packaging after the resulting product is inspected to be qualified.

Comparative Example 1

[0210] The difference between this Comparative Example from Example 1 was that in this example, no bioactive glass was contained, and other components and preparation process were the same as those in Example 1.

Comparative Example 2

[0211] Compared with Example 1, the bioactive glass in the tooth strip formula of Comparative Example 2 was the bioactive glass involved in patent CN201910763871.1 (that is, it was composed of SiO.sub.2, CaO, K.sub.2O, P.sub.2O.sub.5, CaF.sub.2 and Na.sub.2O at a weight ratio of 42:21:14:3:12:15), in which a content of P.sub.2O.sub.5 was low (1.29 mol %) and a content of CaF.sub.2 was high (9.38 mol %). A content of P.sub.2O.sub.5 in the bioactive glass involved in Example 1 was greater than 2 mol %, and was greater than the content of P.sub.2O.sub.5 involved in Comparative Example 2; while a content of CaF.sub.2 was 6.0 mol %. The other relevant conditions of Example 1 are the same with those of Comparative Example 2.

[0212] Studies have shown that increasing a content of P.sub.2O.sub.5 in the bioactive glass can increase the rate and yield of apatite formation from the bioactive glass, thereby improving the remineralization capacity of the material (as shown in FIG. 1). In addition, the bioactive glass involved in Example 1 contains CaF.sub.2 with a content of 6.0 mol %, which leads to generation of acid-resistant fluorapatite rather than calcium fluoride crystals after glass degradation, thereby providing better remineralization capacity of material.

EXPERIMENTAL EXAMPLES

[0213] FIG. 1 shows X-ray diffraction patterns of products of two series of bioactive glass with different phosphorus contents, the product being obtained after soaking the bioactive glass in a buffer solution for one week, in which FIG. 1(a) belongs to low-phosphorus bioactive glass (glass number is A-H, and a phosphorus content of the glass is about 1 mol %), FIG. 1(b) belongs to high-phosphorus bioactive glass (glass number is A2-H2, and its phosphorus content is about 5 mol %), and the main difference between two pieces of glass with the same letter number lies in phosphorus content.

[0214] Taking the glass A in FIG. 1(a) and the glass A2 in FIG. 1(b) as examples, the inventors found that X-ray diffraction peaks matched with apatite can be seen in the XRD patterns of both the low-phosphorus bioactive glass (A) and the high-phosphorus bioactive glass (A2). However, the intensity of the X-ray diffraction peak of apatite generated in the glass A2 is much larger than that in the glass A, revealing that the high-phosphorus bioactive glass can produce apatite faster and more than the low-phosphorus bioactive glass.

[0215] FIG. 2 shows scanning electron micrographs of the distribution of bioactive glass in the tooth strip with remineralization capability obtained in Example 1 and Example 2 of the present application, in which, FIG. (a) shows the distribution of bioactive glass in the tooth strip obtained in Example 1; and FIG. (b) shows the distribution of bioactive glass in the tooth strip obtained in Example 2.

[0216] As shown in FIG. 2(a), the bioactive glass was uniformly dispersed in the tooth strip obtained in Example 1 of the present application. As shown in FIG. 2(b), the bioactive ingredient was uniformly dispersed in the tooth strip obtained in Example 2 of the present application. The small white particles in the figures are all bioactive ingredients (as indicated by circles).

[0217] FIG. 3 is a diagram showing the whitening efficacy of a tooth strip with remineralization capability on an in-vitro model of teeth staining caused by different substances, the tooth strip being obtained in Example 1 of the present application and used for 3, 7, and 14 days (The substance in FIG. 3a is coffee, from left to right: untreatedafter 14 days of coffee stainingafter 3 days of using the tooth stripafter 7 days of using the tooth stripafter 14 days of using the tooth strip; the substance in FIG. 3b is black tea, from left to right: untreatedafter 14 days of black tea stainingafter 3 days of using the tooth stripafter 7 days of using the tooth stripafter 14 days of using the tooth strip).

[0218] As shown in FIG. 3, the color of the in-vitro teeth becomes darker after 14 days of staining with coffee and black tea respectively. After stained in-vitro teeth treatment of 3 days, 7 days and 14 days with the tooth strip with remineralization capability obtained in Example 1, the color of the in-vitro teeth in both groups gradually becomes lighter. It can be seen that the tooth strip with remineralization capability obtained in Example 1 has a better whitening effect.

[0219] FIG. 4 is a diagram showing the whitening efficacy of a tooth strip with remineralization capability on an in-vitro model of teeth staining caused by different substances, the tooth strip being obtained in Example 2 of the present application and used for 3 days, 7 days and 14 days (The substance in FIG. 4a is coffee, from left to right: untreatedafter 14 days of coffee stainingafter 3 days of using the tooth stripafter 7 days of using the tooth stripafter 14 days of using the tooth strip; the substance in FIG. 4b is black tea, from left to right: untreatedafter 14 days of black tea stainingafter 3 days of using the tooth stripafter 7 days of using the tooth stripafter 14 day of using the tooth strip).

[0220] As shown in FIG. 4, the color of the in-vitro teeth becomes darker after 14 days of staining with coffee and black tea. After stained in-vitro teeth treatment of 3 days, 7 days and 14 days with the tooth strip with remineralization capability obtained in Example 2, the color of the in-vitro teeth in both groups gradually becomes lighter. It can be seen that the tooth strip with remineralization capability obtained in Example 2 has a better whitening effect.

[0221] FIG. 5 is a schematic diagram of the degree of tooth whitening after use of the tooth strip obtained in Example 1, Example 2 and Comparative Example 2 of the present application (from left to right, Comparative Example 2, Example 1 and Example 2, respectively).

[0222] The tooth strips obtained in Examples 1 and 2 have a better whitening efficacy than that of Comparative Example 2 after 3 and 7 days of use. The tooth strips obtained in Examples 1 and 2 have the same good whitening efficacy as that of Comparative Example 2 after 14 days of use.

[0223] FIG. 6 is a graph showing the formation of a remineralization layer on the enamel surface of the in-vitro teeth after 7 days treatment with the tooth strips obtained in Example 1 and Comparative Example 1 of the present application respectively, in which (a) is the result of Comparative Example 1, and (b) is the result of Example 1.

[0224] As shown in FIG. 6, no obvious remineralization layer is formed on the enamel surface of the in-vitro teeth treated with the tooth strip of Comparative Example 1; and an obvious apatite remineralization layer is formed on the enamel surface of the in-vitro teeth treated with the tooth strip of Example 1, which has obvious repair effect on the demineralized enamel.

[0225] FIG. 7 is a graph comparing the effects of the tooth strips of Examples and Comparative Examples of the present application on coffee-stained enamel hardness (Comparative Example 1 is the tooth strip C in the figure, Example 1 is the tooth strip I in the figure, and Example 2 is the tooth strip II in the figure).

[0226] As shown in FIG. 7, a hardness of the tooth enamel is significantly increased after treatment with the tooth strip of Example 1 for 7 days and after treatment with the tooth strip of Example 2 for 14 days as compared to the tooth strip of Comparative Example 1.

[0227] FIG. 8 is a scanning electron micrograph of the tooth strips obtained in Example 3 and Comparative Example 1 of the present application, the tooth strips being immersed in artificial saliva for 7 days, in which (a) is a scanning electron micrograph of the tooth strip obtained in Comparative Example 1 after being immersed in artificial saliva for 7 days, and (b) is a scanning electronic micrograph of the tooth strip obtained in Example 3; as shown in FIG. 8, the tooth strip of Example 3 is able to produce more apatite precipitates than Comparative Example 1 after 7 days of immersion.

[0228] FIG. 9 is a structural diagram of the tooth strip with remineralization capability obtained in Example 1 of the present application. The structure of the tooth strip with remineralization capability obtained in Example 1 of the present application includes a three-layer structure: 1) a peel-off backing layer, 2) a dental gel layer, and 3) an anti-sticking liner.

[0229] The above description is only preferred embodiment of the present application, and it should be noted that, for those of ordinary skill in the art, a number of modification and changes can be made without departing from the inventive concept of the present application, and these modification and changes fall within the scope of protection of this application.