SIRNA TARGETING TMPRSS6 FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS

Abstract

The invention relates to a Matriptase-2 (MT2) and/or TMPRSS6 inhibitor for the prevention, decrease of the risk of suffering from or treatment of a myeloproliferative disorder.

Claims

1. A double-stranded nucleic acid that is capable of inhibiting expression of TMPRSS6, for use in the prevention, decrease of the risk of suffering from or treatment of a myeloproliferative disorder, wherein the nucleic acid comprises a first strand and a second strand, wherein the first strand sequence comprises a sequence of at least 15 nucleotides differing by no more than 3 nucleotides from any one of the sequences selected from SEQ ID NO: 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34 and 36.

2. The nucleic acid for use according to claim 1, wherein said first strand comprises a sequence of SEQ ID NO: 6.

3. The nucleic acid for use according to claim 1 or claim 2, wherein the second strand comprises a sequence of SEQ ID NO: 7.

4. The nucleic acid for use according to any of the preceding claims, wherein the first strand and the second strand form a duplex region of 17-25 nucleotides in length.

5. The nucleic acid for use according to any of the preceding claims, wherein at least one nucleotide of the first and/or second strand is a modified nucleotide.

6. The nucleic acid for use according to any of the preceding claims, wherein the nucleic acid comprises a phosphorothioate linkage between the terminal two or three 3 nucleotides and/or 5 nucleotides of the first and/or the second strand and optionally wherein the linkages between the remaining nucleotides are phosphodiester linkages.

7. The nucleic acid for use according to any of the preceding claims, wherein the first strand comprises a sequence of SEQ ID NO: 3.

8. The nucleic acid for use according to any of the preceding claims, wherein the second strand comprises a sequence of SEQ ID No: 1386 or of SEQ ID NO: 1387.

9. The nucleic acid for use according to any of the preceding claims, wherein the nucleic acid is conjugated to a ligand.

10. The nucleic acid for use according to claim 9, wherein the ligand comprises (i) one or more N-acetyl galactosamine (GalNAc) moieties or derivatives thereof, and (ii) a linker, wherein the linker conjugates the at least one GalNAc moiety or derivative thereof to the nucleic acid.

11. The nucleic acid for use according to claim 9 or claim 10, wherein the nucleic acid is conjugated to a ligand. of the following structure ##STR00058## wherein the terminal phosphorothioate group of the ligand moiety is bonded to the 5position of the 5terminal nucleotide of the second strand of the nucleic acid (denoted by Z) or to the 3 position of the 3terminal nucleotide of the second strand of the nucleic acid (denoted by Z).

12. A composition for use in the prevention, decrease of the risk of suffering from or treatment of a myeloproliferative disorder comprising a nucleic acid defined in any of claims 1-11 and a solvent and/or a delivery vehicle and/or a physiologically acceptable excipient and/or a carrier and/or a salt and/or a diluent and/or a buffer and/or a preservative and/or a further therapeutic agent selected from an oligonucleotide, a small molecule, a monoclonal antibody, a polyclonal antibody and a peptide.

13. A method of preventing, decreasing the risk of suffering from, or treating a myeloproliferative disorder comprising administering a pharmaceutically effective amount of a nucleic acid defined in any of claims 1-11, or of a composition defined in claim 12 to an individual in need of treatment.

14. The nucleic acid for use according to any of claims 1-9, or the composition for use according to claim 12, or the method according to claim 13, wherein the myeloproliferative disorder is: a) a Philadelphia chromosome (BCR-ABL) negative myeloproliferative neoplasm; b) one or several of polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF); or c) polycythemia vera (PV).

15. The nucleic acid for use according to any of claims 1-9, or the composition for use according to claim 12, or the method according to claim 13, wherein the myeloproliferative disorder is polycythaemia vera.

16. The nucleic acid for use according to any of claims 1-9, or the composition for use according to claim 12, or the method according to claim 13, wherein the myeloproliferative disorder is JAK2 positive polycythaemia vera.

Description

BRIEF DESCRIPTION OF THE FIGURES

[0621] FIG. 1 shows the effect on different parameters of treating polycythaemia vera mice models or control mice with a TMPRSS6 siRNA GalNAc conjugate.

[0622] FIG. 2 shows the effect on different parameters of treating polycythaemia vera mice models or control mice with a TMPRSS6 siRNA GalNAc conjugate.

[0623] FIG. 3 shows SEQ ID NO: 1385: the TMPRSS6 mRNA sequence: NM_153609.4 Homo sapiens transmembrane serine protease 6 (TMPRSS6), transcript variant 2, mRNA.

[0624] FIG. 4 shows a dose dependent reduction of TMPRSS6 mRNA levels in primary hepatocytes by TMPRSS6 siRNA conjugates EU401 and EU402 by receptor mediated uptake.

EXAMPLES

Example 1Synthesis of Building Blocks

[0625] Synthesis of (vp)-mU-phos was performed as described in Prakash, Nucleic Acids Res. 2015, 43(6), 2993-3011 and Haraszti, Nucleic Acids Res. 2017, 45(13), 7581-7592. Synthesis of the phosphoramidite derivatives of ST41 (ST41-phos), ST43 (ST43-phos) as well as ST23 (ST23-phos) and similar can be performed as described in WO2017/174657.

Example 2Oligonucleotide Synthesis

[0626] Example compounds were synthesised according to methods described below and known to the person skilled in the art. Assembly of the oligonucleotide chain and linker building blocks was performed by solid phase synthesis applying phosphoramidite methodology.

[0627] Downstream cleavage, deprotection and purification followed standard procedures that are known in the art.

[0628] Oligonucleotide syntheses was performed on an AKTA oligopilot 10 using commercially available 2O-Methyl RNA and 2Fluoro-2Deoxy RNA base loaded CPG solid support and phosphoramidites (all standard protection, ChemGenes, LinkTech) were used.

[0629] Ancillary reagents were purchased from EMP Biotech. Synthesis was performed using a 0.1 M solution of the phosphoramidite in dry acetonitrile (<20 ppm H.sub.2O) and benzylthiotetrazole (BTT) was used as activator (0.3M in acetonitrile). Coupling time was 10 min. A Cap/OX/Cap or Cap/Thio/Cap cycle was applied (Cap: AC.sub.2O/NMI/Lutidine/Acetonitrile, Oxidizer: 0.05M 12 in pyridine/H.sub.2O). Phosphorothioates were introduced using commercially available thiolation reagent 50 mM EDITH in acetonitrile (Link technologies). DMT cleavage was achieved by treatment with 3% dichloroacetic acid in toluene. Upon completion of the programmed synthesis cycles a diethylamine (DEA) wash was performed. All oligonucleotides were synthesized in DMT-off mode.

[0630] Tri-antennary GalNAc clusters (ST23/ST43 or ST23/ST41) were introduced by successive coupling of the branching trebler amidite derivative (ST43-phos or ST41-phos) followed by the GalNAc amidite (ST23-phos). Attachment of (vp)-mU moiety was achieved by use of (vp)-mU-phos in the last synthesis cycle. The (vp)-mU-phos does not provide a hydroxy group suitable for further synthesis elongation and therefore, does not possess an DMT-group. Hence coupling of (vp)-mU-phos results in synthesis termination.

[0631] For the removal of the methyl esters masking the vinylphosphonate, the CPG carrying the fully assembled oligonucleotide was dried under reduced pressure and transferred into a 20 ml PP syringe reactor for solid phase peptide synthesis equipped with a disc frit (Carl Roth GmbH). The CPG was then brought into contact with a solution of 250 ?L TMSBr and 177 L pyridine in CH.sub.2Cl.sub.2 (0.5 ml/?mol solid support bound oligonucleotide) at room temperature and the reactor was sealed with a Luer cap. The reaction vessels were slightly agitated over a period of 2?15 min, the excess reagent discarded, and the residual CPG washed 2? with 10 ml acetonitrile. Further downstream processing did not alter from any other example compound.

[0632] The single strands were cleaved off the CPG by 40% aq. methylamine treatment (90 min, RT). The resulting crude oligonucleotide was purified by ion exchange chromatography (Resource Q, 6 ml, GE Healthcare) on a AKTA Pure HPLC System using a sodium chloride gradient. Product containing fractions were pooled, desalted on a size exclusion column (Zetadex, EMP Biotech) and lyophilised until further use.

[0633] All final single-stranded products were analysed by AEX-HPLC to prove their purity. Identity of the respective single-stranded products was proved by LC-MS analysis.

Example 3Double-Strand Formation

[0634] Individual single strands were dissolved in a concentration of 60 OD/ml in H.sub.2O. Both individual oligonucleotide solutions were added together in a reaction vessel. For easier reaction monitoring a titration was performed. The first strand was added in 25% excess over the second strand as determined by UV-absorption at 260 nm. The reaction mixture was heated to 80? C. for 5 min and then slowly cooled to RT. Double-strand formation was monitored by ion pairing reverse phase HPLC. From the UV-area of the residual single strand the needed amount of the second strand was calculated and added to the reaction mixture. The reaction was heated to 80? C. again and slowly cooled to RT. This procedure was repeated until less than 10% of residual single strand was detected.

Example 4

[0635] Inhibition of TMPRSS6 expression by TMPRSS6 siRNA treatment in a rodent model for polycythaemia vera (PV) leads to an increase of hepcidin levels and a reduction of serum iron levels.

[0636] A rodent model for polycythemia vera (PV) was established by transplantation of murine haematopoietic stem cells that carry one inducible human JAK2V617F allele and a Cre recombinase transgene under the control of the Tamoxifen inducible promoter (CreERT2) into preconditioned wild type Ly5.1/J recipient mice. Control animals received haematopoietic stem cells that carry only the JAK2V617F knock-in allele (JAK2 KI control). 46 days after transplantation, engraftment was confirmed by blood analysis. 49 days after transplantation, expression of the JAK2V617F transgene was activated in the PV mouse model by administration of Tamoxifen (4.2 mg by oral gavage in 10% ethanol/90% corn oil) on two consecutive days. The different genotypes (JAK2 KI control and PV) were each randomized into three groups and treated on Day 56, Day 77 and Day 98 after transplantation with either the vehicle (PBS), 5 mg GalNAc conjugated TMPRSS6 siRNA (EU401) or 5 mg non-targeting control siRNA molecule (EU400) per kg body weight. On Day 105 after transplantation all animals were humanely euthanized and tissue and blood samples collected for analyses. Liver tissue samples were stored in nucleic acid preserving media (RNAlater) and total RNA extracted to measure target gene expression by qRT-PCR. Serum samples were prepared from terminal blood samples and hepcidin levels were determined by ELISA assay and serum iron levels were determined using an Abbott ARCHITECT analyzer with the MULTIGENT Iron assay. Tissue non-haem iron levels were determined by the Ferrozine method from shock-frozen liver samples.

[0637] Treatment with EU401 reduces hepatic Tmprss6 mRNA expression in the control mice as well as in the rodent model for polycythaemia vera (PV). EU401 treatment also raises hepatic Hamp1 mRNA levels and serum hepcidin levels and reduces serum iron levels in control mice and in the PV mouse model. Hepatic iron levels were not significantly affected by the treatment with EU401.

[0638] Statistics: Experimental data are presented as bar chart with median?95% CI. Distribution-free Mann-Whitney U tests were used for the pairwise comparisons. Data was considered statistically significant, if the P-value was ? 0.05 (ns: P >0.05; * P? 0.05; ** P? 0.01; *** P? 0.001, *** P? 0.0001). The test statistics were not corrected for multiple testing.

[0639] Results are shown in FIG. 1A) Tmprss6 mRNA levels in liver, B) Hamp1 mRNA level in liver, C) Hepcidin level in serum, D) Iron levels in serum, E) Iron levels in liver tissue. Tmprss6 and Hamp1 mRNA levels are depicted normalized to the house keeping gene Hprt and presented as fold change vs PBS treated JAK2 KI control (set to 1). siRNAs are listed in Table 2.

[0640] Similar results to those obtained with EU401 are expected with EU402 and possibly other inhibitors of MP2 function or expression.

Example 5

[0641] Reduction of haemoglobin and haematocrit by GalNAc-conjugated TMPRSS6 siRNA in an animal model for polycythaemia vera.

[0642] A rodent model for polycythaemia vera (PV) was set up and treated with vehicle (PBS), EU401 and EU400 as described in Example 4. At the end of the study, terminal blood samples and bone marrow were collected. Full blood cell counts were determined by automatic haemocytometer (Advia 2120i) and red blood cell maturation was assessed in the bone marrow by flow cytometry as previously described (Chen et al., 2009, PNAS, 106(41): 17413-17418).

[0643] Treatment with EU401 reduces haemoglobin and haematocrit in the blood of the rodent model for polycythaemia vera (PV) and in the control mice. EU401 treatment also reduces the mean corpuscular volume in the PV model and in the control mice, when compared to the corresponding control group of the same genotype that received either the vehicle or EU400. EU401 resets red blood cell maturation in the bone marrow of the PV mouse model by normalizing the mature red cell population and expanding progenitor populations.

[0644] Statistics: Experimental data are presented as bar chart with median+95% CI. Distribution-free Mann-Whitney U tests were used for the pairwise comparisons. Data was considered statistically significant, if the P-value was ? 0.05 (ns: P >0.05; * P? 0.05; ** P? 0.01; *** P? 0.001, *** P? 0.0001). The test statistics were not corrected for multiple testing. The proportion of erythroid progenitor populations are presented by stacked bar chart with mean?SD.

[0645] Results are shown in FIG. 2A) Haemoglobin (HGB), B) Haematocrit (HCT), C) Mean corpuscular volume (MCV) in red blood cells, D) Red blood cell maturation in the bone marrow. siRNAs are listed in Table 2.

[0646] Similar results to those obtained with EU401 are expected with EU402 and possibly other inhibitors of MP2 function or expression.

Example 6

[0647] Reduction of TMPRSS6 mRNA levels in primary hepatocytes

[0648] Primary mouse hepatocytes were seeded in a 96 well plate at a density of 25,000 cells per well. After plating, cells were incubated with the TMPRSS6 siRNA conjugates EU401 and EU402 in the cell culture medium at different concentrations (100 nM, 33 nM, 11 nM, 3.7, 1.2 nM, 0.41 nM and 0.14 nM). The following day cells were lysed for RNA extraction and TMPRSS6 and Actin mRNA levels were determined by Taqman qRT-PCR. Values obtained for TMPRSS6 mRNA were normalized to values generated for the house keeping gene, Actin, and related to mean of untreated sample (ut) set at 1-fold target gene expression. Each bar represents mean+/?SD from three biological replicates. siRNA conjugates EU401 and EU402 used in this study are further described in Table 2 and Table 4.

[0649] The results shown in FIG. 4 demonstrate a dose dependent reduction of TMPRSS6 mRNA levels in primary hepatocytes by TMPRSS6 siRNA conjugates EU401 and EU402 by receptor mediated uptake.

Summary Tables

Summary Duplex Table

[0650]

TABLE-US-00002 TABLE 2 Single Single Single Duplex Strands Duplex Strands Duplex Strands EU400 EU400A AL1-214 AL1-214A AL2-222 AL2-222A EU400B AL1-214B AL2-222B EU401 EU401A AL1-215 AL1-215A AL2-223 AL2-223A EU401B AL1-215B AL2-223B EU402 EU401A AL1-216 AL1-216A AL2-224 AL2-224A EU402B AL1-216B AL2-224B TMPRSS6-hc-1 TMPRSS6-hc-1A AL1-217 AL1-217A AL2-225 AL2-225A TMPRSS6-hc-1B AL1-217B AL2-225B TMPRSS6-h-2 TMPRSS6-h-2A AL1-218 AL1-218A AL2-226 AL2-226A TMPRSS6-h-2B AL1-218B AL2-226B TMPRSS6-h-3 TMPRSS6-h-3A AL1-219 AL1-219A AL2-227 AL2-227A TMPRSS6-h-3B AL1-219B AL2-227B TMPRSS6-hc-4 TMPRSS6-hc-4A AL1-220 AL1-220A AL2-228 AL2-228A TMPRSS6-hc-4B AL1-220B AL2-228B TMPRSS6-h-5 TMPRSS6-h-5A AL1-221 AL1-221A AL2-229 AL2-229A TMPRSS6-h-5B AL1-221B AL2-229B TMPRSS6-h-6 TMPRSS6-h-6A AL1-222 AL1-222A AL2-230 AL2-230A TMPRSS6-h-6B AL1-222B AL2-230B TMPRSS6-h-7 TMPRSS6-h-7A AL1-223 AL1-223A AL2-231 AL2-231A TMPRSS6-h-7B AL1-223B AL2-231B TMPRSS6-hcmr-8 TMPRSS6-hcmr-8A AL2-1 AL2-1A AL2-232 AL2-232A TMPRSS6-hcmr-8B AL2-1B AL2-232B TMPRSS6-hcm-9 TMPRSS6-hcm-9A AL2-2 AL2-2A AL2-233 AL2-233A TMPRSS6-hcm-9B AL2-2B AL2-233B TMPRSS6-hc-10 TMPRSS6-hc-10A AL2-3 AL2-3A AL2-234 AL2-234A TMPRSS6-hc-10B AL2-3B AL2-234B TMPRSS6-hc-11 TMPRSS6-hc-11A AL2-4 AL2-4A AL2-235 AL2-235A TMPRSS6-hc-11B AL2-4B AL2-235B TMPRSS6-hcm-12 TMPRSS6-hcm-12A AL2-5 AL2-5A AL2-236 AL2-236A TMPRSS6-hcm-12B AL2-5B AL2-236B TMPRSS6-hc-13 TMPRSS6-hc-13A AL2-6 AL2-6A AL2-237 AL2-237A TMPRSS6-hc-13B AL2-6B AL2-237B TMPRSS6-hcmr-14 TMPRSS6-hcmr-14A AL2-7 AL2-7A AL2-238 AL2-238A TMPRSS6-hcmr-14B AL2-7B AL2-238B TMPRSS6-hcmr-15 TMPRSS6-hcmr-15A AL2-8 AL2-8A AL2-239 AL2-239A TMPRSS6-hcmr-15B AL2-8B AL2-239B AL1-1 AL1-1A AL2-9 AL2-9A AL2-240 AL2-240A AL1-1B AL2-9B AL2-240B AL1-2 AL1-2A AL2-10 AL2-10A AL2-241 AL2-241A AL1-2B AL2-10B AL2-241B AL1-3 AL1-3A AL2-11 AL2-11A AL2-242 AL2-242A AL1-3B AL2-11B AL2-242B AL1-4 AL1-4A AL2-12 AL2-12A AL2-243 AL2-243A AL1-4B AL2-12B AL2-243B AL1-5 AL1-5A AL2-13 AL2-13A AL2-244 AL2-244A AL1-5B AL2-13B AL2-244B AL1-6 AL1-6A AL2-14 AL2-14A AL2-245 AL2-245A AL1-6B AL2-14B AL2-245B AL1-7 AL1-7A AL2-15 AL2-15A AL2-246 AL2-246A AL1-7B AL2-15B AL2-246B AL1-8 AL1-8A AL2-16 AL2-16A AL2-247 AL2-247A AL1-8B AL2-16B AL2-247B AL1-9 AL1-9A AL2-17 AL2-17A AL2-248 AL2-248A AL1-9B AL2-17B AL2-248B AL1-10 AL1-10A AL2-18 AL2-18A AL2-249 AL2-249A AL1-10B AL2-18B AL2-249B AL1-11 AL1-11A AL2-19 AL2-19A AL2-250 AL2-250A AL1-11B AL2-19B AL2-250B AL1-12 AL1-12A AL2-20 AL2-20A AL2-251 AL2-251A AL1-12B AL2-20B AL2-251B AL1-13 AL1-13A AL2-21 AL2-21A AL2-252 AL2-252A AL1-13B AL2-21B AL2-252B AL1-14 AL1-14A AL2-22 AL2-22A AL2-253 AL2-253A AL1-14B AL2-22B AL2-253B AL1-15 AL1-15A AL2-23 AL2-23A AL2-254 AL2-254A AL1-15B AL2-23B AL2-254B AL1-16 AL1-16A AL2-24 AL2-24A AL2-255 AL2-255A AL1-16B AL2-24B AL2-255B AL1-17 AL1-17A AL2-25 AL2-25A AL2-256 AL2-256A AL1-17B AL2-25B AL2-256B AL1-18 AL1-18A AL2-26 AL2-26A AL2-257 AL2-257A AL1-18B AL2-26B AL2-257B AL1-19 AL1-19A AL2-27 AL2-27A AL2-258 AL2-258A AL1-19B AL2-27B AL2-258B AL1-20 AL1-20A AL2-28 AL2-28A AL2-259 AL2-259A AL1-20B AL2-28B AL2-259B AL1-21 AL1-21A AL2-29 AL2-29A AL2-260 AL2-260A AL1-21B AL2-29B AL2-260B AL1-22 AL1-22A AL2-30 AL2-30A AL2-261 AL2-261A AL1-22B AL2-30B AL2-261B AL1-23 AL1-23A AL2-31 AL2-31A AL2-262 AL2-262A AL1-23B AL2-31B AL2-262B AL1-24 AL1-24A AL2-32 AL2-32A AL2-263 AL2-263A AL1-24B AL2-32B AL2-263B AL1-25 AL1-25A AL2-33 AL2-33A AL2-264 AL2-264A AL1-25B AL2-33B AL2-264B AL1-26 AL1-26A AL2-34 AL2-34A AL2-265 AL2-265A AL1-26B AL2-34B AL2-265B AL1-27 AL1-27A AL2-35 AL2-35A AL2-266 AL2-266A AL1-27B AL2-35B AL2-266B AL1-28 AL1-28A AL2-36 AL2-36A AL2-267 AL2-267A AL1-28B AL2-36B AL2-267B AL1-29 AL1-29A AL2-37 AL2-37A AL2-268 AL2-268A AL1-29B AL2-37B AL2-268B AL1-30 AL1-30A AL2-38 AL2-38A AL2-269 AL2-269A AL1-30B AL2-38B AL2-269B AL1-31 AL1-31A AL2-39 AL2-39A AL2-270 AL2-270A AL1-31B AL2-39B AL2-270B AL1-32 AL1-32A AL2-40 AL2-40A AL2-271 AL2-271A AL1-32B AL2-40B AL2-271B AL1-33 AL1-33A AL2-41 AL2-41A AL2-272 AL2-272A AL1-33B AL2-41B AL2-272B AL1-34 AL1-34A AL2-42 AL2-42A AL2-273 AL2-273A AL1-34B AL2-42B AL2-273B AL1-35 AL1-35A AL2-43 AL2-43A AL2-274 AL2-274A AL1-35B AL2-43B AL2-274B AL1-36 AL1-36A AL2-44 AL2-44A AL2-275 AL2-275A AL1-36B AL2-44B AL2-275B AL1-37 AL1-37A AL2-45 AL2-45A AL2-276 AL2-276A AL1-37B AL2-45B AL2-276B AL1-38 AL1-38A AL2-46 AL2-46A AL2-277 AL2-277A AL1-38B AL2-46B AL2-277B AL1-39 AL1-39A AL2-47 AL2-47A AL2-278 AL2-278A AL1-39B AL2-47B AL2-278B AL1-40 AL1-40A AL2-48 AL2-48A AL2-279 AL2-279A AL1-40B AL2-48B AL2-279B AL1-41 AL1-41A AL2-49 AL2-49A AL2-280 AL2-280A AL1-41B AL2-49B AL2-280B AL1-42 AL1-42A AL2-50 AL2-50A AL2-281 AL2-281A AL1-42B AL2-50B AL2-281B AL1-43 AL1-43A AL2-51 AL2-51A AL2-282 AL2-282A AL1-43B AL2-51B AL2-282B AL1-44 AL1-44A AL2-52 AL2-52A AL2-283 AL2-283A AL1-44B AL2-52B AL2-283B AL1-45 AL1-45A AL2-53 AL2-53A AL2-284 AL2-284A AL1-45B AL2-53B AL2-284B AL1-46 AL1-46A AL2-54 AL2-54A AL2-285 AL2-285A AL1-46B AL2-54B AL2-285B AL1-47 AL1-47A AL2-55 AL2-55A AL2-286 AL2-286A AL1-47B AL2-55B AL2-286B AL1-48 AL1-48A AL2-56 AL2-56A AL2-287 AL2-287A AL1-48B AL2-56B AL2-287B AL1-49 AL1-49A AL2-57 AL2-57A AL2-288 AL2-288A AL1-49B AL2-57B AL2-288B AL1-50 AL1-50A AL2-58 AL2-58A AL2-289 AL2-289A AL1-50B AL2-58B AL2-289B AL1-51 AL1-51A AL2-59 AL2-59A AL2-290 AL2-290A AL1-51B AL2-59B AL2-290B AL1-52 AL1-52A AL2-60 AL2-60A AL2-291 AL2-291A AL1-52B AL2-60B AL2-291B AL1-53 AL1-53A AL2-61 AL2-61A AL2-292 AL2-292A AL1-53B AL2-61B AL2-292B AL1-54 AL1-54A AL2-62 AL2-62A AL2-293 AL2-293A AL1-54B AL2-62B AL2-293B AL1-55 AL1-55A AL2-63 AL2-63A AL2-294 AL2-294A AL1-55B AL2-63B AL2-294B AL1-56 AL1-56A AL2-64 AL2-64A AL2-295 AL2-295A AL1-56B AL2-64B AL2-295B AL1-57 AL1-57A AL2-65 AL2-65A AL2-296 AL2-296A AL1-57B AL2-65B AL2-296B AL1-58 AL1-58A AL2-66 AL2-66A AL2-297 AL2-297A AL1-58B AL2-66B AL2-297B AL1-59 AL1-59A AL2-67 AL2-67A AL2-298 AL2-298A AL1-59B AL2-67B AL2-298B AL1-60 AL1-60A AL2-68 AL2-68A AL2-299 AL2-299A AL1-60B AL2-68B AL2-299B AL1-61 AL1-61A AL2-69 AL2-69A AL2-300 AL2-300A AL1-61B AL2-69B AL2-300B AL1-62 AL1-62A AL2-70 AL2-70A AL2-301 AL2-301A AL1-62B AL2-70B AL2-301B AL1-63 AL1-63A AL2-71 AL2-71A AL2-302 AL2-302A AL1-63B AL2-71B AL2-302B AL1-64 AL1-64A AL2-72 AL2-72A AL2-303 AL2-303A AL1-64B AL2-72B AL2-303B AL1-65 AL1-65A AL2-73 AL2-73A AL2-304 AL2-304A AL1-65B AL2-73B AL2-304B AL1-66 AL1-66A AL2-74 AL2-74A AL2-305 AL2-305A AL1-66B AL2-74B AL2-305B AL1-67 AL1-67A AL2-75 AL2-75A AL2-306 AL2-306A AL1-67B AL2-75B AL2-306B AL1-68 AL1-68A AL2-76 AL2-76A AL2-307 AL2-307A AL1-68B AL2-76B AL2-307B AL1-69 AL1-69A AL2-77 AL2-77A AL2-308 AL2-308A AL1-69B AL2-77B AL2-308B AL1-70 AL1-70A AL2-78 AL2-78A AL2-309 AL2-309A AL1-70B AL2-78B AL2-309B AL1-71 AL1-71A AL2-79 AL2-79A AL2-310 AL2-310A AL1-71B AL2-79B AL2-310B AL1-72 AL1-72A AL2-80 AL2-80A AL2-311 AL2-311A AL1-72B AL2-80B AL2-311B AL1-73 AL1-73A AL2-81 AL2-81A AL2-312 AL2-312A AL1-73B AL2-81B AL2-312B AL1-74 AL1-74A AL2-82 AL2-82A AL2-313 AL2-313A AL1-74B AL2-82B AL2-313B AL1-75 AL1-75A AL2-83 AL2-83A AL2-314 AL2-314A AL1-75B AL2-83B AL2-314B AL1-76 AL1-76A AL2-84 AL2-84A AL2-315 AL2-315A AL1-76B AL2-84B AL2-315B AL1-77 AL1-77A AL2-85 AL2-85A AL2-316 AL2-316A AL1-77B AL2-85B AL2-316B AL1-78 AL1-78A AL2-86 AL2-86A AL2-317 AL2-317A AL1-78B AL2-86B AL2-317B AL1-79 AL1-79A AL2-87 AL2-87A AL2-318 AL2-318A AL1-79B AL2-87B AL2-318B AL1-80 AL1-80A AL2-88 AL2-88A AL2-319 AL2-319A AL1-80B AL2-88B AL2-319B AL1-81 AL1-81A AL2-89 AL2-89A AL2-320 AL2-320A AL1-81B AL2-89B AL2-320B AL1-82 AL1-82A AL2-90 AL2-90A AL2-321 AL2-321A AL1-82B AL2-90B AL2-321B AL1-83 AL1-83A AL2-91 AL2-91A AL2-322 AL2-322A AL1-83B AL2-91B AL2-322B AL1-84 AL1-84A AL2-92 AL2-92A AL2-323 AL2-323A AL1-84B AL2-92B AL2-323B AL1-85 AL1-85A AL2-93 AL2-93A AL2-324 AL2-324A AL1-85B AL2-93B AL2-324B AL1-86 AL1-86A AL2-94 AL2-94A AL2-325 AL2-325A AL1-86B AL2-94B AL2-325B AL1-87 AL1-87A AL2-95 AL2-95A AL2-326 AL2-326A AL1-87B AL2-95B AL2-326B AL1-88 AL1-88A AL2-96 AL2-96A AL2-327 AL2-327A AL1-88B AL2-96B AL2-327B AL1-89 AL1-89A AL2-97 AL2-97A AL2-328 AL2-328A AL1-89B AL2-97B AL2-328B AL1-90 AL1-90A AL2-98 AL2-98A AL2-329 AL2-329A AL1-90B AL2-98B AL2-329B AL1-91 AL1-91A AL2-99 AL2-99A AL2-330 AL2-330A AL1-91B AL2-99B AL2-330B AL1-92 AL1-92A AL2-100 AL2-100A AL2-331 AL2-331A AL1-92B AL2-100B AL2-331B AL1-93 AL1-93A AL2-101 AL2-101A AL2-332 AL2-332A AL1-93B AL2-101B AL2-332B AL1-94 AL1-94A AL2-102 AL2-102A AL2-333 AL2-333A AL1-94B AL2-102B AL2-333B AL1-95 AL1-95A AL2-103 AL2-103A AL2-334 AL2-334A AL1-95B AL2-103B AL2-334B AL1-96 AL1-96A AL2-104 AL2-104A AL2-335 AL2-335A AL1-96B AL2-104B AL2-335B AL1-97 AL1-97A AL2-105 AL2-105A AL2-336 AL2-336A AL1-97B AL2-105B AL2-336B AL1-98 AL1-98A AL2-106 AL2-106A AL2-337 AL2-337A AL1-98B AL2-106B AL2-337B AL1-99 AL1-99A AL2-107 AL2-107A AL2-338 AL2-338A AL1-99B AL2-107B AL2-338B AL1-100 AL1-100A AL2-108 AL2-108A AL2-339 AL2-339A AL1-100B AL2-108B AL2-339B AL1-101 AL1-101A AL2-109 AL2-109A AL2-340 AL2-340A AL1-101B AL2-109B AL2-340B AL1-102 AL1-102A AL2-110 AL2-110A AL2-341 AL2-341A AL1-102B AL2-110B AL2-341B AL1-103 AL1-103A AL2-111 AL2-111A AL2-342 AL2-342A AL1-103B AL2-111B AL2-342B AL1-104 AL1-104A AL2-112 AL2-112A AL2-343 AL2-343A AL1-104B AL2-112B AL2-343B AL1-105 AL1-105A AL2-113 AL2-113A AL2-344 AL2-344A AL1-105B AL2-113B AL2-344B AL1-106 AL1-106A AL2-114 AL2-114A AL2-345 AL2-345A AL1-106B AL2-114B AL2-345B AL1-107 AL1-107A AL2-115 AL2-115A AL2-346 AL2-346A AL1-107B AL2-115B AL2-346B AL1-108 AL1-108A AL2-116 AL2-116A AL2-347 AL2-347A AL1-108B AL2-116B AL2-347B AL1-109 AL1-109A AL2-117 AL2-117A AL2-348 AL2-348A AL1-109B AL2-117B AL2-348B AL1-110 AL1-110A AL2-118 AL2-118A AL2-349 AL2-349A AL1-110B AL2-118B AL2-349B AL1-111 AL1-111A AL2-119 AL2-119A AL2-350 AL2-350A AL1-111B AL2-119B AL2-350B AL1-112 AL1-112A AL2-120 AL2-120A AL2-351 AL2-351A AL1-112B AL2-120B AL2-351B AL1-113 AL1-113A AL2-121 AL2-121A AL2-352 AL2-352A AL1-113B AL2-121B AL2-352B AL1-114 AL1-114A AL2-122 AL2-122A AL2-353 AL2-353A AL1-114B AL2-122B AL2-353B AL1-115 AL1-115A AL2-123 AL2-123A AL2-354 AL2-354A AL1-115B AL2-123B AL2-354B AL1-116 AL1-116A AL2-124 AL2-124A AL2-355 AL2-355A AL1-116B AL2-124B AL2-355B AL1-117 AL1-117A AL2-125 AL2-125A AL2-356 AL2-356A AL1-117B AL2-125B AL2-356B AL1-118 AL1-118A AL2-126 AL2-126A AL2-357 AL2-357A AL1-118B AL2-126B AL2-357B AL1-119 AL1-119A AL2-127 AL2-127A AL2-358 AL2-358A AL1-119B AL2-127B AL2-358B AL1-120 AL1-120A AL2-128 AL2-128A AL2-359 AL2-359A AL1-120B AL2-128B AL2-359B AL1-121 AL1-121A AL2-129 AL2-129A AL2-360 AL2-360A AL1-121B AL2-129B AL2-360B AL1-122 AL1-122A AL2-130 AL2-130A AL2-361 AL2-361A AL1-122B AL2-130B AL2-361B AL1-123 AL1-123A AL2-131 AL2-131A AL2-362 AL2-362A AL1-123B AL2-131B AL2-362B AL1-124 AL1-124A AL2-132 AL2-132A AL2-363 AL2-363A AL1-124B AL2-132B AL2-363B AL1-125 AL1-125A AL2-133 AL2-133A AL2-364 AL2-364A AL1-125B AL2-133B AL2-364B AL1-126 AL1-126A AL2-134 AL2-134A AL2-365 AL2-365A AL1-126B AL2-134B AL2-365B AL1-127 AL1-127A AL2-135 AL2-135A AL2-366 AL2-366A AL1-127B AL2-135B AL2-366B AL1-128 AL1-128A AL2-136 AL2-136A AL2-367 AL2-367A AL1-128B AL2-136B AL2-367B AL1-129 AL1-129A AL2-137 AL2-137A AL2-368 AL2-368A AL1-129B AL2-137B AL2-368B AL1-130 AL1-130A AL2-138 AL2-138A AL2-369 AL2-369A AL1-130B AL2-138B AL2-369B AL1-131 AL1-131A AL2-139 AL2-139A AL2-370 AL2-370A AL1-131B AL2-139B AL2-370B AL1-132 AL1-132A AL2-140 AL2-140A AL2-371 AL2-371A AL1-132B AL2-140B AL2-371B AL1-133 AL1-133A AL2-141 AL2-141A AL2-372 AL2-372A AL1-133B AL2-141B AL2-372B AL1-134 AL1-134A AL2-142 AL2-142A AL2-373 AL2-373A AL1-134B AL2-142B AL2-373B AL1-135 AL1-135A AL2-143 AL2-143A AL2-374 AL2-374A AL1-135B AL2-143B AL2-374B AL1-136 AL1-136A AL2-144 AL2-144A AL2-375 AL2-375A AL1-136B AL2-144B AL2-375B AL1-137 AL1-137A AL2-145 AL2-145A AL2-376 AL2-376A AL1-137B AL2-145B AL2-376B AL1-138 AL1-138A AL2-146 AL2-146A AL2-377 AL2-377A AL1-138B AL2-146B AL2-377B AL1-139 AL1-139A AL2-147 AL2-147A AL2-378 AL2-378A AL1-139B AL2-147B AL2-378B AL1-140 AL1-140A AL2-148 AL2-148A AL2-379 AL2-379A AL1-140B AL2-148B AL2-379B AL1-141 AL1-141A AL2-149 AL2-149A AL2-380 AL2-380A AL1-141B AL2-149B AL2-380B AL1-142 AL1-142A AL2-150 AL2-150A AL2-381 AL2-381A AL1-142B AL2-150B AL2-381B AL1-143 AL1-143A AL2-151 AL2-151A AL2-382 AL2-382A AL1-143B AL2-151B AL2-382B AL1-144 AL1-144A AL2-152 AL2-152A AL2-383 AL2-383A AL1-144B AL2-152B AL2-383B AL1-145 AL1-145A AL2-153 AL2-153A AL2-384 AL2-384A AL1-145B AL2-153B AL2-384B AL1-146 AL1-146A AL2-154 AL2-154A AL2-385 AL2-385A AL1-146B AL2-154B AL2-385B AL1-147 AL1-147A AL2-155 AL2-155A AL2-386 AL2-386A AL1-147B AL2-155B AL2-386B AL1-148 AL1-148A AL2-156 AL2-156A AL2-387 AL2-387A AL1-148B AL2-156B AL2-387B AL1-149 AL1-149A AL2-157 AL2-157A AL2-388 AL2-388A AL1-149B AL2-157B AL2-388B AL1-150 AL1-150A AL2-158 AL2-158A AL2-389 AL2-389A AL1-150B AL2-158B AL2-389B AL1-151 AL1-151A AL2-159 AL2-159A AL2-390 AL2-390A AL1-151B AL2-159B AL2-390B AL1-152 AL1-152A AL2-160 AL2-160A AL2-391 AL2-391A AL1-152B AL2-160B AL2-391B AL1-153 AL1-153A AL2-161 AL2-161A AL2-392 AL2-392A AL1-153B AL2-161B AL2-392B AL1-154 AL1-154A AL2-162 AL2-162A AL2-393 AL2-393A AL1-154B AL2-162B AL2-393B AL1-155 AL1-155A AL2-163 AL2-163A AL2-394 AL2-394A AL1-155B AL2-163B AL2-394B AL1-156 AL1-156A AL2-164 AL2-164A AL2-395 AL2-395A AL1-156B AL2-164B AL2-395B AL1-157 AL1-157A AL2-165 AL2-165A AL2-396 AL2-396A AL1-157B AL2-165B AL2-396B AL1-158 AL1-158A AL2-166 AL2-166A AL2-397 AL2-397A AL1-158B AL2-166B AL2-397B AL1-159 AL1-159A AL2-167 AL2-167A AL2-398 AL2-398A AL1-159B AL2-167B AL2-398B AL1-160 AL1-160A AL2-168 AL2-168A AL2-399 AL2-399A AL1-160B AL2-168B AL2-399B AL1-161 AL1-161A AL2-169 AL2-169A AL2-400 AL2-400A AL1-161B AL2-169B AL2-400B AL1-162 AL1-162A AL2-170 AL2-170A AL2-401 AL2-401A AL1-162B AL2-170B AL2-401B AL1-163 AL1-163A AL2-171 AL2-171A AL2-402 AL2-402A AL1-163B AL2-171B AL2-402B AL1-164 AL1-164A AL2-172 AL2-172A AL2-403 AL2-403A AL1-164B AL2-172B AL2-403B AL1-165 AL1-165A AL2-173 AL2-173A AL2-404 AL2-404A AL1-165B AL2-173B AL2-404B AL1-166 AL1-166A AL2-174 AL2-174A AL2-405 AL2-405A AL1-166B AL2-174B AL2-405B AL1-167 AL1-167A AL2-175 AL2-175A AL2-406 AL2-406A AL1-167B AL2-175B AL2-406B AL1-168 AL1-168A AL2-176 AL2-176A AL2-407 AL2-407A AL1-168B AL2-176B AL2-407B AL1-169 AL1-169A AL2-177 AL2-177A AL2-408 AL2-408A AL1-169B AL2-177B AL2-408B AL1-170 AL1-170A AL2-178 AL2-178A AL2-409 AL2-409A AL1-170B AL2-178B AL2-409B AL1-171 AL1-171A AL2-179 AL2-179A AL2-410 AL2-410A AL1-171B AL2-179B AL2-410B AL1-172 AL1-172A AL2-180 AL2-180A AL2-411 AL2-411A AL1-172B AL2-180B AL2-411B AL1-173 AL1-173A AL2-181 AL2-181A AL2-412 AL2-412A AL1-173B AL2-181B AL2-412B AL1-174 AL1-174A AL2-182 AL2-182A AL2-413 AL2-413A AL1-174B AL2-182B AL2-413B AL1-175 AL1-175A AL2-183 AL2-183A AL2-414 AL2-414A AL1-175B AL2-183B AL2-414B AL1-176 AL1-176A AL2-184 AL2-184A AL2-415 AL2-415A AL1-176B AL2-184B AL2-415B AL1-177 AL1-177A AL2-185 AL2-185A AL2-416 AL2-416A AL1-177B AL2-185B AL2-416B AL1-178 AL1-178A AL2-186 AL2-186A AL2-417 AL2-417A AL1-178B AL2-186B AL2-417B AL1-179 AL1-179A AL2-187 AL2-187A AL2-418 AL2-418A AL1-179B AL2-187B AL2-418B AL1-180 AL1-180A AL2-188 AL2-188A AL2-419 AL2-419A AL1-180B AL2-188B AL2-419B AL1-181 AL1-181A AL2-189 AL2-189A AL2-420 AL2-420A AL1-181B AL2-189B AL2-420B AL1-182 AL1-182A AL2-190 AL2-190A AL2-421 AL2-421A AL1-182B AL2-190B AL2-421B AL1-183 AL1-183A AL2-191 AL2-191A AL2-422 AL2-422A AL1-183B AL2-191B AL2-422B AL1-184 AL1-184A AL2-192 AL2-192A AL2-423 AL2-423A AL1-184B AL2-192B AL2-423B AL1-185 AL1-185A AL2-193 AL2-193A AL2-424 AL2-424A AL1-185B AL2-193B AL2-424B AL1-186 AL1-186A AL2-194 AL2-194A AL2-425 AL2-425A AL1-186B AL2-194B AL2-425B AL1-187 AL1-187A AL2-195 AL2-195A AL2-426 AL2-426A AL1-187B AL2-195B AL2-426B AL1-188 AL1-188A AL2-196 AL2-196A AL2-427 AL2-427A AL1-188B AL2-196B AL2-427B AL1-189 AL1-189A AL2-197 AL2-197A AL2-428 AL2-428A AL1-189B AL2-197B AL2-428B AL1-190 AL1-190A AL2-198 AL2-198A AL2-429 AL2-429A AL1-190B AL2-198B AL2-429B AL1-191 AL1-191A AL2-199 AL2-199A AL2-430 AL2-430A AL1-191B AL2-199B AL2-430B AL1-192 AL1-192A AL2-200 AL2-200A AL2-431 AL2-431A AL1-192B AL2-200B AL2-431B AL1-193 AL1-193A AL2-201 AL2-201A AL2-432 AL2-432A AL1-193B AL2-201B AL2-432B AL1-194 AL1-194A AL2-202 AL2-202A AL2-433 AL2-433A AL1-194B AL2-202B AL2-433B AL1-195 AL1-195A AL2-203 AL2-203A AL2-434 AL2-434A AL1-195B AL2-203B AL2-434B AL1-196 AL1-196A AL2-204 AL2-204A AL2-435 AL2-435A AL1-196B AL2-204B AL2-435B AL1-197 AL1-197A AL2-205 AL2-205A AL2-436 AL2-436A AL1-197B AL2-205B AL2-436B AL1-198 AL1-198A AL2-206 AL2-206A AL2-437 AL2-437A AL1-198B AL2-206B AL2-437B AL1-199 AL1-199A AL2-207 AL2-207A AL2-438 AL2-438A AL1-199B AL2-207B AL2-438B AL1-200 AL1-200A AL2-208 AL2-208A AL2-439 AL2-439A AL1-200B AL2-208B AL2-439B AL1-201 AL1-201A AL2-209 AL2-209A AL2-440 AL2-440A AL1-201B AL2-209B AL2-440B AL1-202 AL1-202A AL2-210 AL2-210A AL2-441 AL2-441A AL1-202B AL2-210B AL2-441B AL1-203 AL1-203A AL2-211 AL2-211A AL2-442 AL2-442A AL1-203B AL2-211B AL2-442B AL1-204 AL1-204A AL2-212 AL2-212A AL2-443 AL2-443A AL1-204B AL2-212B AL2-443B AL1-205 AL1-205A AL2-213 AL2-213A AL2-444 AL2-444A AL1-205B AL2-213B AL2-444B AL1-206 AL1-206A AL2-214 AL2-214A AL2-445 AL2-445A AL1-206B AL2-214B AL2-445B AL1-207 AL1-207A AL2-215 AL2-215A AL2-446 AL2-446A AL1-207B AL2-215B AL2-446B AL1-208 AL1-208A AL2-216 AL2-216A AL2-447 AL2-447A AL1-208B AL2-216B AL2-447B AL1-209 AL1-209A AL2-217 AL2-217A AL2-448 AL2-448A AL1-209B AL2-217B AL2-448B AL1-210 AL1-210A AL2-218 AL2-218A AL2-449 AL2-449A AL1-210B AL2-218B AL2-449B AL1-211 AL1-211A AL2-219 AL2-219A AL2-450 AL2-450A AL1-211B AL2-219B AL2-450B AL1-212 AL1-212A AL2-220 AL2-220A AL2-451 AL2-451A AL1-212B AL2-220B AL2-451B AL1-213 AL1-213A AL2-221 AL2-221A AL1-213B AL2-221B

Summary Abbreviations Table

[0651]

TABLE-US-00003 TABLE 3 Abbreviation Meaning mA, mU, mC, 2-O-Methyl RNA nucleotides mG 2-OMe 2-O-Methyl modification fA, fU, fC, fG 2 deoxy-2-F RNA nucleotides 2-F 2-fluoro modification (ps) phosphorothioate (ps2) phosphorodithioate (vp) Vinyl-(E)-phosphonate (vp)-mU [00047] (vp)-mU-phos [00048] ivA, ivC, ivU, inverted RNA (3-3) nucleotides ivG ST23 [00049] ST23-phos [00050] ST43 (or C6XLT) [00051] ST43-phos (or C6XLT-phos) [00052] Ser (GN) (when at the end of a chain, one of the O is OH) [00053] [ST23 (ps)]3 ST43 (ps) [00054] [ST23]3 ST43 [00055] [ST23(ps)]3 ST41(ps) [00056] [ST23]3 ST41 [00057]

[0652] The abbreviations as shown in the above abbreviation table may be used herein. The list of abbreviations may not be exhaustive and further abbreviations and their meaning may be found throughout this document.

Summary Sequence Table

[0653]

TABLE-US-00004 TABLE4 SEQ Name ID (A=1.sup.ststrand; Unmodifiedsequence5-3 NO: B=2.sup.ndstrand) Sequence5-3 counterpart 1 EU400A mU(ps)fC(ps)mGfAmAfGmUfAmUfUmCfCmG UCGAAGUAUUCCGCGUACG fCmGfUmA(ps)fC(ps)mG 2 EU400B [ST23(ps)]3ST43(ps)mCmGmUmAmCmGFCfGfG CGUACGCGGAAUACUUCGA mAmAmUmAmCmUmUmC(ps)mG(ps)mA 3 EU401A mA(ps)fA(ps)mCfCmAfGmAfAmGfAmAfGmC AACCAGAAGAAGCAGGUGA fAmGfGmU(ps)fG(ps)mA 4 EU401B [ST23(ps)]3ST43(ps)mUmCmAmCmCmUfGfCfU UCACCUGCUUCUUCUGGUU mUmCmUmUmCmUmGmG(ps)mU(ps)mU 5 EU402B [ST23(ps)]3ST41(ps)fUmCfAmCfCmUfGmCfU UCACCUGCUUCUUCUGGUU mUfCmUfUmCfUmGfG(ps)mU(ps)fU 6 EU401Aun AACCAGAAGAAGCAGGUGA AACCAGAAGAAGCAGGUGA 7 EU401Bun UCACCUGCUUCUUCUGGUU UCACCUGCUUCUUCUGGUU 8 TMPRSS6-hc-1A AUGUCUUUCACACUGGCUU AUGUCUUUCACACUGGCUU 9 TMPRSS6-hc-1B AAGCCAGUGUGAAAGACAU AAGCCAGUGUGAAAGACAU 10 TMPRSS6-h-2A AUUGAGUACACGCAGACUG AUUGAGUACACGCAGACUG 11 TMPRSS6-h-2B CAGUCUGCGUGUACUCAAU CAGUCUGCGUGUACUCAAU 12 TMPRSS6-h-3A AAGUUGAUGGUGAUCCCGG AAGUUGAUGGUGAUCCCGG 13 TMPRSS6-h-3B CCGGGAUCACCAUCAACUU CCGGGAUCACCAUCAACUU 14 TMPRSS6-hc-4A UUCUGGAUCGUCCACUGGC UUCUGGAUCGUCCACUGGC 15 TMPRSS6-hc-4B GCCAGUGGACGAUCCAGAA GCCAGUGGACGAUCCAGAA 16 TMPRSS6-h-5A AUUCACAGAACAGAGGAAC AUUCACAGAACAGAGGAAC 17 TMPRSS6-h-5B GUUCCUCUGUUCUGUGAAU GUUCCUCUGUUCUGUGAAU 18 TMPRSS6-h-6A GUAGUCAUGGCUGUCCUCU GUAGUCAUGGCUGUCCUCU 19 TMPRSS6-h-6B AGAGGACAGCCAUGACUAC AGAGGACAGCCAUGACUAC 20 TMPRSS6-h-7A AGUUGUAGUAAGUUCCCAG AGUUGUAGUAAGUUCCCAG 21 TMPRSS6-h-7B CUGGGAACUUACUACAACU CUGGGAACUUACUACAACU 22 TMPRSS6-hcmr-8A UUGUACCCUAGGAAAUACC UUGUACCCUAGGAAAUACC 23 TMPRSS6-hcmr-8B GGUAUUUCCUAGGGUACAA GGUAUUUCCUAGGGUACAA 24 TMPRSS6-hcm-9A AACCAGAAGAAGCAGGUGA AACCAGAAGAAGCAGGUGA 25 TMPRSS6-hcm-9B UCACCUGCUUCUUCUGGUU UCACCUGCUUCUUCUGGUU 26 TMPRSS6-hc-10A UAACAACCCAGCGUGGAAU UAACAACCCAGCGUGGAAU 27 TMPRSS6-hc-10B AUUCCACGCUGGGUUGUUA AUUCCACGCUGGGUUGUUA 28 TMPRSS6-hc-11A GUUUCUCUCAUCCAGGCCG GUUUCUCUCAUCCAGGCCG 29 TMPRSS6-hc-11B CGGCCUGGAUGAGAGAAAC CGGCCUGGAUGAGAGAAAC 30 TMPRSS6-hcm-12A GCAUCUUCUGGGCUUUGGC GCAUCUUCUGGGCUUUGGC 31 TMPRSS6-hcm-12B GCCAAAGCCCAGAAGAUGC GCCAAAGCCCAGAAGAUGC 32 TMPRSS6-hc-13A UCACACUGGAAGGUGAAUG UCACACUGGAAGGUGAAUG 33 TMPRSS6-hc-13B CAUUCACCUUCCAGUGUGA CAUUCACCUUCCAGUGUGA 34 TMPRSS6-hcmr-14A CACAGAUGUGUCGACCCCG CACAGAUGUGUCGACCCCG 35 TMPRSS6-hcmr-14B CGGGGUCGACACAUCUGUG CGGGGUCGACACAUCUGUG 36 TMPRSS6-hcmr-15A UGUACCCUAGGAAAUACCA UGUACCCUAGGAAAUACCA 37 TMPRSS6-hcmr-15B UGGUAUUUCCUAGGGUACA UGGUAUUUCCUAGGGUACA 38 AL1-1A AGGUCAGCUCGCACCAGAG AGGUCAGCUCGCACCAGAG 39 AL1-1B CUCUGGUGCGAGCUGACCU CUCUGGUGCGAGCUGACCU 40 AL1-2A AGUGCAUCUCAGGUCAGCU AGUGCAUCUCAGGUCAGCU 41 AL1-2B AGCUGACCUGAGAUGCACU AGCUGACCUGAGAUGCACU 42 AL1-3A UGCCGAGACAGCUCACAGA UGCCGAGACAGCUCACAGA 43 AL1-3B UCUGUGAGCUGUCUCGGCA UCUGUGAGCUGUCUCGGCA 44 AL1-4A AGUGGGUGCCGAGACAGCU AGUGGGUGCCGAGACAGCU 45 AL1-4B AGCUGUCUCGGCACCCACU AGCUGUCUCGGCACCCACU 46 AL1-5A AAGUGGGUGCCGAGACAGC AAGUGGGUGCCGAGACAGC 47 AL1-5B GCUGUCUCGGCACCCACUU GCUGUCUCGGCACCCACUU 48 AL1-6A ACAUCAGGCGGCAGUGACU ACAUCAGGCGGCAGUGACU 49 AL1-6B AGUCACUGCCGCCUGAUGU AGUCACUGCCGCCUGAUGU 50 AL1-7A AACAACAUCAGGCGGCAGU AACAACAUCAGGCGGCAGU 51 AL1-7B ACUGCCGCCUGAUGUUGUU ACUGCCGCCUGAUGUUGUU 52 AL1-8A UAACAACAUCAGGCGGCAG UAACAACAUCAGGCGGCAG 53 AL1-8B CUGCCGCCUGAUGUUGUUA CUGCCGCCUGAUGUUGUUA 54 AL1-9A AGUAACAACAUCAGGCGGC AGUAACAACAUCAGGCGGC 55 AL1-9B GCCGCCUGAUGUUGUUACU GCCGCCUGAUGUUGUUACU 56 AL1-10A AAGAGUAACAACAUCAGGC AAGAGUAACAACAUCAGGC 57 AL1-10B GCCUGAUGUUGUUACUCUU GCCUGAUGUUGUUACUCUU 58 AL1-11A UCCUUUUGGAGUGGAAGAG UCCUUUUGGAGUGGAAGAG 59 AL1-11B CUCUUCCACUCCAAAAGGA CUCUUCCACUCCAAAAGGA 60 AL1-12A ACGGGCAUCCUUUUGGAGU ACGGGCAUCCUUUUGGAGU 61 AL1-12B ACUCCAAAAGGAUGCCCGU ACUCCAAAAGGAUGCCCGU 62 AL1-13A UUUCUCUUGGAGUCCUCAC UUUCUCUUGGAGUCCUCAC 63 AL1-13B GUGAGGACUCCAAGAGAAA GUGAGGACUCCAAGAGAAA 64 AL1-14A AGUAGCACCCCCGCCGAAG AGUAGCACCCCCGCCGAAG 65 AL1-14B CUUCGGCGGGGGUGCUACU CUUCGGCGGGGGUGCUACU 66 AL1-15A AGAGUAGCACCCCCGCCGA AGAGUAGCACCCCCGCCGA 67 AL1-15B UCGGCGGGGGUGCUACUCU UCGGCGGGGGUGCUACUCU 68 AL1-16A ACCAGAGUAGCACCCCCGC ACCAGAGUAGCACCCCCGC 69 AL1-16B GCGGGGGUGCUACUCUGGU GCGGGGGUGCUACUCUGGU 70 AL1-17A AUACCAGAGUAGCACCCCC AUACCAGAGUAGCACCCCC 71 AL1-17B GGGGGUGCUACUCUGGUAU GGGGGUGCUACUCUGGUAU 72 AL1-18A AAUACCAGAGUAGCACCCC AAUACCAGAGUAGCACCCC 73 AL1-18B GGGGUGCUACUCUGGUAUU GGGGUGCUACUCUGGUAUU 74 AL1-19A UACCCUAGGAAAUACCAGA UACCCUAGGAAAUACCAGA 75 AL1-19B UCUGGUAUUUCCUAGGGUA UCUGGUAUUUCCUAGGGUA 76 AL1-20A UGUACCCUAGGAAAUACCA UGUACCCUAGGAAAUACCA 77 AL1-20B UGGUAUUUCCUAGGGUACA UGGUAUUUCCUAGGGUACA 78 AL1-21A UUGUACCCUAGGAAAUACC UUGUACCCUAGGAAAUACC 79 AL1-21B GGUAUUUCCUAGGGUACAA GGUAUUUCCUAGGGUACAA 80 AL1-22A UGAGUACACCUGGCUGACC UGAGUACACCUGGCUGACC 81 AL1-22B GGUCAGCCAGGUGUACUCA GGUCAGCCAGGUGUACUCA 82 AL1-23A UGCCUGAGUACACCUGGCU UGCCUGAGUACACCUGGCU 83 AL1-23B AGCCAGGUGUACUCAGGCA AGCCAGGUGUACUCAGGCA 84 AL1-24A ACGCAGACUGCCUGAGUAC ACGCAGACUGCCUGAGUAC 85 AL1-24B GUACUCAGGCAGUCUGCGU GUACUCAGGCAGUCUGCGU 86 AL1-25A ACACGCAGACUGCCUGAGU ACACGCAGACUGCCUGAGU 87 AL1-25B ACUCAGGCAGUCUGCGUGU ACUCAGGCAGUCUGCGUGU 88 AL1-26A AGUACACGCAGACUGCCUG AGUACACGCAGACUGCCUG 89 AL1-26B CAGGCAGUCUGCGUGUACU CAGGCAGUCUGCGUGUACU 90 AL1-27A UGAGUACACGCAGACUGCC UGAGUACACGCAGACUGCC 91 AL1-27B GGCAGUCUGCGUGUACUCA GGCAGUCUGCGUGUACUCA 92 AL1-28A UUGAGUACACGCAGACUGC UUGAGUACACGCAGACUGC 93 AL1-28B GCAGUCUGCGUGUACUCAA GCAGUCUGCGUGUACUCAA 94 AL1-29A AUUGAGUACACGCAGACUG AUUGAGUACACGCAGACUG 95 AL1-29B CAGUCUGCGUGUACUCAAU CAGUCUGCGUGUACUCAAU 96 AL1-30A UGGCGAUUGAGUACACGCA UGGCGAUUGAGUACACGCA 97 AL1-30B UGCGUGUACUCAAUCGCCA UGCGUGUACUCAAUCGCCA 98 AL1-31A AGUGGCGAUUGAGUACACG AGUGGCGAUUGAGUACACG 99 AL1-31B CGUGUACUCAAUCGCCACU CGUGUACUCAAUCGCCACU 100 AL1-32A AAGUGGCGAUUGAGUACAC AAGUGGCGAUUGAGUACAC 101 AL1-32B GUGUACUCAAUCGCCACUU GUGUACUCAAUCGCCACUU 102 AL1-33A AGAAGUGGCGAUUGAGUAC AGAAGUGGCGAUUGAGUAC 103 AL1-33B GUACUCAAUCGCCACUUCU GUACUCAAUCGCCACUUCU 104 AL1-34A UAAGAUCCUGGGAGAAGUG UAAGAUCCUGGGAGAAGUG 105 AL1-34B CACUUCUCCCAGGAUCUUA CACUUCUCCCAGGAUCUUA 106 AL1-35A AUUCCCGGCGGGUAAGAUC AUUCCCGGCGGGUAAGAUC 107 AL1-35B GAUCUUACCCGCCGGGAAU GAUCUUACCCGCCGGGAAU 108 AL1-36A AGAUUCCCGGCGGGUAAGA AGAUUCCCGGCGGGUAAGA 109 AL1-36B UCUUACCCGCCGGGAAUCU UCUUACCCGCCGGGAAUCU 110 AL1-37A UAGAUUCCCGGCGGGUAAG UAGAUUCCCGGCGGGUAAG 111 AL1-37B CUUACCCGCCGGGAAUCUA CUUACCCGCCGGGAAUCUA 112 AL1-38A ACUAGAUUCCCGGCGGGUA ACUAGAUUCCCGGCGGGUA 113 AL1-38B UACCCGCCGGGAAUCUAGU UACCCGCCGGGAAUCUAGU 114 AL1-39A AGGCACUAGAUUCCCGGCG AGGCACUAGAUUCCCGGCG 115 AL1-39B CGCCGGGAAUCUAGUGCCU CGCCGGGAAUCUAGUGCCU 116 AL1-40A AAGGCACUAGAUUCCCGGC AAGGCACUAGAUUCCCGGC 117 AL1-40B GCCGGGAAUCUAGUGCCUU GCCGGGAAUCUAGUGCCUU 118 AL1-41A UUGGCGGUUUCACUGCGGA UUGGCGGUUUCACUGCGGA 119 AL1-41B UCCGCAGUGAAACCGCCAA UCCGCAGUGAAACCGCCAA 120 AL1-42A UUUGGCGGUUUCACUGCGG UUUGGCGGUUUCACUGCGG 121 AL1-42B CCGCAGUGAAACCGCCAAA CCGCAGUGAAACCGCCAAA 122 AL1-43A UGUAGUAAGUUCCCAGGCG UGUAGUAAGUUCCCAGGCG 123 AL1-43B CGCCUGGGAACUUACUACA CGCCUGGGAACUUACUACA 124 AL1-44A UUGUAGUAAGUUCCCAGGC UUGUAGUAAGUUCCCAGGC 125 AL1-44B GCCUGGGAACUUACUACAA GCCUGGGAACUUACUACAA 126 AL1-45A AGUUGUAGUAAGUUCCCAG AGUUGUAGUAAGUUCCCAG 127 AL1-45B CUGGGAACUUACUACAACU CUGGGAACUUACUACAACU 128 AL1-46A AGACGGAGCUGGAGUUGUA AGACGGAGCUGGAGUUGUA 129 AL1-46B UACAACUCCAGCUCCGUCU UACAACUCCAGCUCCGUCU 130 AL1-47A UAGACGGAGCUGGAGUUGU UAGACGGAGCUGGAGUUGU 131 AL1-47B ACAACUCCAGCUCCGUCUA ACAACUCCAGCUCCGUCUA 132 AL1-48A AAUAGACGGAGCUGGAGUU AAUAGACGGAGCUGGAGUU 133 AL1-48B AACUCCAGCUCCGUCUAUU AACUCCAGCUCCGUCUAUU 134 AL1-49A UGAGGGGUCCCUCCCCAAA UGAGGGGUCCCUCCCCAAA 135 AL1-49B UUUGGGGAGGGACCCCUCA UUUGGGGAGGGACCCCUCA 136 AL1-50A AGAAGCAGGUGAGGGGUCC AGAAGCAGGUGAGGGGUCC 137 AL1-50B GGACCCCUCACCUGCUUCU GGACCCCUCACCUGCUUCU 138 AL1-51A AGAAUGAACCAGAAGAAGC AGAAUGAACCAGAAGAAGC 139 AL1-51B GCUUCUUCUGGUUCAUUCU GCUUCUUCUGGUUCAUUCU 140 AL1-52A UGGAGAAUGAACCAGAAGA UGGAGAAUGAACCAGAAGA 141 AL1-52B UCUUCUGGUUCAUUCUCCA UCUUCUGGUUCAUUCUCCA 142 AL1-53A AGCAUCAGCCGGCGGUGCU AGCAUCAGCCGGCGGUGCU 143 AL1-53B AGCACCGCCGGCUGAUGCU AGCACCGCCGGCUGAUGCU 144 AL1-54A UACUCGGCCCUGUAGGGGA UACUCGGCCCUGUAGGGGA 145 AL1-54B UCCCCUACAGGGCCGAGUA UCCCCUACAGGGCCGAGUA 146 AL1-55A UCGUACUCGGCCCUGUAGG UCGUACUCGGCCCUGUAGG 147 AL1-55B CCUACAGGGCCGAGUACGA CCUACAGGGCCGAGUACGA 148 AL1-56A ACUUCGUACUCGGCCCUGU ACUUCGUACUCGGCCCUGU 149 AL1-56B ACAGGGCCGAGUACGAAGU ACAGGGCCGAGUACGAAGU 150 AL1-57A UCCACUUCGUACUCGGCCC UCCACUUCGUACUCGGCCC 151 AL1-57B GGGCCGAGUACGAAGUGGA GGGCCGAGUACGAAGUGGA 152 AL1-58A AGGAUCACUAGGCCCUCGG AGGAUCACUAGGCCCUCGG 153 AL1-58B CCGAGGGCCUAGUGAUCCU CCGAGGGCCUAGUGAUCCU 154 AL1-59A AGCUAUGUCUUUCACACUG AGCUAUGUCUUUCACACUG 155 AL1-59B CAGUGUGAAAGACAUAGCU CAGUGUGAAAGACAUAGCU 156 AL1-60A ACAACCCAGCGUGGAAUUC ACAACCCAGCGUGGAAUUC 157 AL1-60B GAAUUCCACGCUGGGUUGU GAAUUCCACGCUGGGUUGU 158 AL1-61A AACAACCCAGCGUGGAAUU AACAACCCAGCGUGGAAUU 159 AL1-61B AAUUCCACGCUGGGUUGUU AAUUCCACGCUGGGUUGUU 160 AL1-62A AGCGGUAACAACCCAGCGU AGCGGUAACAACCCAGCGU 161 AL1-62B ACGCUGGGUUGUUACCGCU ACGCUGGGUUGUUACCGCU 162 AL1-63A UAGCGGUAACAACCCAGCG UAGCGGUAACAACCCAGCG 163 AL1-63B CGCUGGGUUGUUACCGCUA CGCUGGGUUGUUACCGCUA 164 AL1-64A UGUAGCGGUAACAACCCAG UGUAGCGGUAACAACCCAG 165 AL1-64B CUGGGUUGUUACCGCUACA CUGGGUUGUUACCGCUACA 166 AL1-65A AGCUGUAGCGGUAACAACC AGCUGUAGCGGUAACAACC 167 AL1-65B GGUUGUUACCGCUACAGCU GGUUGUUACCGCUACAGCU 168 AL1-66A ACGUAGCUGUAGCGGUAAC ACGUAGCUGUAGCGGUAAC 169 AL1-66B GUUACCGCUACAGCUACGU GUUACCGCUACAGCUACGU 170 AL1-67A AGUUUGAGCAUGAGGUCCU AGUUUGAGCAUGAGGUCCU 171 AL1-67B AGGACCUCAUGCUCAAACU AGGACCUCAUGCUCAAACU 172 AL1-68A AGCCGGAGUUUGAGCAUGA AGCCGGAGUUUGAGCAUGA 173 AL1-68B UCAUGCUCAAACUCCGGCU UCAUGCUCAAACUCCGGCU 174 AL1-69A AGCCGUACACCGAGGUGAU AGCCGUACACCGAGGUGAU 175 AL1-69B AUCACCUCGGUGUACGGCU AUCACCUCGGUGUACGGCU 176 AL1-70A UGCAGCCGUACACCGAGGU UGCAGCCGUACACCGAGGU 177 AL1-70B ACCUCGGUGUACGGCUGCA ACCUCGGUGUACGGCUGCA 178 AL1-71A UCCAGACGACCGCCAUGAU UCCAGACGACCGCCAUGAU 179 AL1-71B AUCAUGGCGGUCGUCUGGA AUCAUGGCGGUCGUCUGGA 180 AL1-72A UUCCAGACGACCGCCAUGA UUCCAGACGACCGCCAUGA 181 AL1-72B UCAUGGCGGUCGUCUGGAA UCAUGGCGGUCGUCUGGAA 182 AL1-73A ACGAAGGGGUCGUAGUAGC ACGAAGGGGUCGUAGUAGC 183 AL1-73B GCUACUACGACCCCUUCGU GCUACUACGACCCCUUCGU 184 AL1-74A AAGACCACCGGCUGCACGG AAGACCACCGGCUGCACGG 185 AL1-74B CCGUGCAGCCGGUGGUCUU CCGUGCAGCCGGUGGUCUU 186 AL1-75A ACUUCACAGGCCUGGAAGA ACUUCACAGGCCUGGAAGA 187 AL1-75B UCUUCCAGGCCUGUGAAGU UCUUCCAGGCCUGUGAAGU 188 AL1-76A UCAGGUUCACUUCACAGGC UCAGGUUCACUUCACAGGC 189 AL1-76B GCCUGUGAAGUGAACCUGA GCCUGUGAAGUGAACCUGA 190 AL1-77A AGCGUCAGGUUCACUUCAC AGCGUCAGGUUCACUUCAC 191 AL1-77B GUGAAGUGAACCUGACGCU GUGAAGUGAACCUGACGCU 192 AL1-78A UCGAGCCUGUUGUCCAGCG UCGAGCCUGUUGUCCAGCG 193 AL1-78B CGCUGGACAACAGGCUCGA CGCUGGACAACAGGCUCGA 194 AL1-79A AGUCGAGCCUGUUGUCCAG AGUCGAGCCUGUUGUCCAG 195 AL1-79B CUGGACAACAGGCUCGACU CUGGACAACAGGCUCGACU 196 AL1-80A AGUACGGGGUGCUGAGGAC AGUACGGGGUGCUGAGGAC 197 AL1-80B GUCCUCAGCACCCCGUACU GUCCUCAGCACCCCGUACU 198 AL1-81A AAGUACGGGGUGCUGAGGA AAGUACGGGGUGCUGAGGA 199 AL1-81B UCCUCAGCACCCCGUACUU UCCUCAGCACCCCGUACUU 200 AL1-82A UGGGGAAGUACGGGGUGCU UGGGGAAGUACGGGGUGCU 201 AL1-82B AGCACCCCGUACUUCCCCA AGCACCCCGUACUUCCCCA 202 AL1-83A UUGGGGCGAGUAGUAGCUG UUGGGGCGAGUAGUAGCUG 203 AL1-83B CAGCUACUACUCGCCCCAA CAGCUACUACUCGCCCCAA 204 AL1-84A UUUGGGGCGAGUAGUAGCU UUUGGGGCGAGUAGUAGCU 205 AL1-84B AGCUACUACUCGCCCCAAA AGCUACUACUCGCCCCAAA 206 AL1-85A UGGGUUUGGGGCGAGUAGU UGGGUUUGGGGCGAGUAGU 207 AL1-85B ACUACUCGCCCCAAACCCA ACUACUCGCCCCAAACCCA 208 AL1-86A AGCAGUGGGUUUGGGGCGA AGCAGUGGGUUUGGGGCGA 209 AL1-86B UCGCCCCAAACCCACUGCU UCGCCCCAAACCCACUGCU 210 AL1-87A ACCGUGAGGUGCCAGGAGC ACCGUGAGGUGCCAGGAGC 211 AL1-87B GCUCCUGGCACCUCACGGU GCUCCUGGCACCUCACGGU 212 AL1-88A AGCCGUAGUCCAGAGAGGG AGCCGUAGUCCAGAGAGGG 213 AL1-88B CCCUCUCUGGACUACGGCU CCCUCUCUGGACUACGGCU 214 AL1-89A AACCAGAGGGCCAAGCCGU AACCAGAGGGCCAAGCCGU 215 AL1-89B ACGGCUUGGCCCUCUGGUU ACGGCUUGGCCCUCUGGUU 216 AL1-90A AAACCAGAGGGCCAAGCCG AAACCAGAGGGCCAAGCCG 217 AL1-90B CGGCUUGGCCCUCUGGUUU CGGCUUGGCCCUCUGGUUU 218 AL1-91A UCAAACCAGAGGGCCAAGC UCAAACCAGAGGGCCAAGC 219 AL1-91B GCUUGGCCCUCUGGUUUGA GCUUGGCCCUCUGGUUUGA 220 AL1-92A AUAGGCAUCAAACCAGAGG AUAGGCAUCAAACCAGAGG 221 AL1-92B CCUCUGGUUUGAUGCCUAU CCUCUGGUUUGAUGCCUAU 222 AL1-93A ACGGCAAAUCAUACUUCUG ACGGCAAAUCAUACUUCUG 223 AL1-93B CAGAAGUAUGAUUUGCCGU CAGAAGUAUGAUUUGCCGU 224 AL1-94A UGCACGGCAAAUCAUACUU UGCACGGCAAAUCAUACUU 225 AL1-94B AAGUAUGAUUUGCCGUGCA AAGUAUGAUUUGCCGUGCA 226 AL1-95A UGGGUGCACGGCAAAUCAU UGGGUGCACGGCAAAUCAU 227 AL1-95B AUGAUUUGCCGUGCACCCA AUGAUUUGCCGUGCACCCA 228 AL1-96A UCGUCCACUGGCCCUGGGU UCGUCCACUGGCCCUGGGU 229 AL1-96B ACCCAGGGCCAGUGGACGA ACCCAGGGCCAGUGGACGA 230 AL1-97A UGGAUCGUCCACUGGCCCU UGGAUCGUCCACUGGCCCU 231 AL1-97B AGGGCCAGUGGACGAUCCA AGGGCCAGUGGACGAUCCA 232 AL1-98A UCUGGAUCGUCCACUGGCC UCUGGAUCGUCCACUGGCC 233 AL1-98B GGCCAGUGGACGAUCCAGA GGCCAGUGGACGAUCCAGA 234 AL1-99A UUCUGGAUCGUCCACUGGC UUCUGGAUCGUCCACUGGC 235 AL1-99B GCCAGUGGACGAUCCAGAA GCCAGUGGACGAUCCAGAA 236 AL1-100A UCCUCUCGGCGUAGGGCUG UCCUCUCGGCGUAGGGCUG 237 AL1-100B CAGCCCUACGCCGAGAGGA CAGCCCUACGCCGAGAGGA 238 AL1-101A AUAGUGCACCCGCACACCG AUAGUGCACCCGCACACCG 239 AL1-101B CGGUGUGCGGGUGCACUAU CGGUGUGCGGGUGCACUAU 240 AL1-102A AGCCAUAGUGCACCCGCAC AGCCAUAGUGCACCCGCAC 241 AL1-102B GUGCGGGUGCACUAUGGCU GUGCGGGUGCACUAUGGCU 242 AL1-103A AAGCCAUAGUGCACCCGCA AAGCCAUAGUGCACCCGCA 243 AL1-103B UGCGGGUGCACUAUGGCUU UGCGGGUGCACUAUGGCUU 244 AL1-104A UACAAGCCAUAGUGCACCC UACAAGCCAUAGUGCACCC 245 AL1-104B GGGUGCACUAUGGCUUGUA GGGUGCACUAUGGCUUGUA 246 AL1-105A UUGUACAAGCCAUAGUGCA UUGUACAAGCCAUAGUGCA 247 AL1-105B UGCACUAUGGCUUGUACAA UGCACUAUGGCUUGUACAA 248 AL1-106A AGAGGAACUCUCCAGGGCA AGAGGAACUCUCCAGGGCA 249 AL1-106B UGCCCUGGAGAGUUCCUCU UGCCCUGGAGAGUUCCUCU 250 AL1-107A ACGCAGUUUCUCUCAUCCA ACGCAGUUUCUCUCAUCCA 251 AL1-107B UGGAUGAGAGAAACUGCGU UGGAUGAGAGAAACUGCGU 252 AL1-108A UGAGAUGCAUGUGCUGUCC UGAGAUGCAUGUGCUGUCC 253 AL1-108B GGACAGCACAUGCAUCUCA GGACAGCACAUGCAUCUCA 254 AL1-109A AGUGAGAUGCAUGUGCUGU AGUGAGAUGCAUGUGCUGU 255 AL1-109B ACAGCACAUGCAUCUCACU ACAGCACAUGCAUCUCACU 256 AL1-110A UGCCCAUCACAGACCUUGG UGCCCAUCACAGACCUUGG 257 AL1-110B CCAAGGUCUGUGAUGGGCA CCAAGGUCUGUGAUGGGCA 258 AL1-111A AGACAAUCAGGCUGCCCAU AGACAAUCAGGCUGCCCAU 259 AL1-111B AUGGGCAGCCUGAUUGUCU AUGGGCAGCCUGAUUGUCU 260 AL1-112A UUGAGACAAUCAGGCUGCC UUGAGACAAUCAGGCUGCC 261 AL1-112B GGCAGCCUGAUUGUCUCAA GGCAGCCUGAUUGUCUCAA 262 AL1-113A UGCCGUUGAGACAAUCAGG UGCCGUUGAGACAAUCAGG 263 AL1-113B CCUGAUUGUCUCAACGGCA CCUGAUUGUCUCAACGGCA 264 AL1-114A UUCGUCGCUGCCGUUGAGA UUCGUCGCUGCCGUUGAGA 265 AL1-114B UCUCAACGGCAGCGACGAA UCUCAACGGCAGCGACGAA 266 AL1-115A AUGGCACCCCUUCCUGGCA AUGGCACCCCUUCCUGGCA 267 AL1-115B UGCCAGGAAGGGGUGCCAU UGCCAGGAAGGGGUGCCAU 268 AL1-116A AUGUCCCACAUGGCACCCC AUGUCCCACAUGGCACCCC 269 AL1-116B GGGGUGCCAUGUGGGACAU GGGGUGCCAUGUGGGACAU 270 AL1-117A UGAAUGUCCCACAUGGCAC UGAAUGUCCCACAUGGCAC 271 AL1-117B GUGCCAUGUGGGACAUUCA GUGCCAUGUGGGACAUUCA 272 AL1-118A AAGGUGAAUGUCCCACAUG AAGGUGAAUGUCCCACAUG 273 AL1-118B CAUGUGGGACAUUCACCUU CAUGUGGGACAUUCACCUU 274 AL1-119A AGCUCCGGUCCUCACACUG AGCUCCGGUCCUCACACUG 275 AL1-119B CAGUGUGAGGACCGGAGCU CAGUGUGAGGACCGGAGCU 276 AL1-120A UGCGGGUUGGGCUUCUUCA UGCGGGUUGGGCUUCUUCA 277 AL1-120B UGAAGAAGCCCAACCCGCA UGAAGAAGCCCAACCCGCA 278 AL1-121A ACACUGCGGGUUGGGCUUC ACACUGCGGGUUGGGCUUC 279 AL1-121B GAAGCCCAACCCGCAGUGU GAAGCCCAACCCGCAGUGU 280 AL1-122A AACAAUGCGGCUGGAGGGG AACAAUGCGGCUGGAGGGG 281 AL1-122B CCCCUCCAGCCGCAUUGUU CCCCUCCAGCCGCAUUGUU 282 AL1-123A UGUGUCGACCCCGAACCUG UGUGUCGACCCCGAACCUG 283 AL1-123B CAGGUUCGGGGUCGACACA CAGGUUCGGGGUCGACACA 284 AL1-124A AUGUGUCGACCCCGAACCU AUGUGUCGACCCCGAACCU 285 AL1-124B AGGUUCGGGGUCGACACAU AGGUUCGGGGUCGACACAU 286 AL1-125A AGAUGUGUCGACCCCGAAC AGAUGUGUCGACCCCGAAC 287 AL1-125B GUUCGGGGUCGACACAUCU GUUCGGGGUCGACACAUCU 288 AL1-126A UAUCACCCAGCGGUCAGCG UAUCACCCAGCGGUCAGCG 289 AL1-126B CGCUGACCGCUGGGUGAUA CGCUGACCGCUGGGUGAUA 290 AL1-127A UUAUCACCCAGCGGUCAGC UUAUCACCCAGCGGUCAGC 291 AL1-127B GCUGACCGCUGGGUGAUAA GCUGACCGCUGGGUGAUAA 292 AL1-128A UGUUAUCACCCAGCGGUCA UGUUAUCACCCAGCGGUCA 293 AL1-128B UGACCGCUGGGUGAUAACA UGACCGCUGGGUGAUAACA 294 AL1-129A AGCUGUUAUCACCCAGCGG AGCUGUUAUCACCCAGCGG 295 AL1-129B CCGCUGGGUGAUAACAGCU CCGCUGGGUGAUAACAGCU 296 AL1-130A AGGAACACGGUCCACAGCA AGGAACACGGUCCACAGCA 297 AL1-130B UGCUGUGGACCGUGUUCCU UGCUGUGGACCGUGUUCCU 298 AL1-131A AGCGCGAGUUCUGCCACAC AGCGCGAGUUCUGCCACAC 299 AL1-131B GUGUGGCAGAACUCGCGCU GUGUGGCAGAACUCGCGCU 300 AL1-132A UCGUGGUACGGGUGCAGGA UCGUGGUACGGGUGCAGGA 301 AL1-132B UCCUGCACCCGUACCACGA UCCUGCACCCGUACCACGA 302 AL1-133A UUCGUGGUACGGGUGCAGG UUCGUGGUACGGGUGCAGG 303 AL1-133B CCUGCACCCGUACCACGAA CCUGCACCCGUACCACGAA 304 AL1-134A UCUUCGUGGUACGGGUGCA UCUUCGUGGUACGGGUGCA 305 AL1-134B UGCACCCGUACCACGAAGA UGCACCCGUACCACGAAGA 306 AL1-135A UCGAAGAAGUGGGAGCGCG UCGAAGAAGUGGGAGCGCG 307 AL1-135B CGCGCUCCCACUUCUUCGA CGCGCUCCCACUUCUUCGA 308 AL1-136A UAAUCCAGCAGUGCAGGCC UAAUCCAGCAGUGCAGGCC 309 AL1-136B GGCCUGCACUGCUGGAUUA GGCCUGCACUGCUGGAUUA 310 AL1-137A AGCCCGUAAUCCAGCAGUG AGCCCGUAAUCCAGCAGUG 311 AL1-137B CACUGCUGGAUUACGGGCU CACUGCUGGAUUACGGGCU 312 AL1-138A UGGGAUCAACUGCACAUCC UGGGAUCAACUGCACAUCC 313 AL1-138B GGAUGUGCAGUUGAUCCCA GGAUGUGCAGUUGAUCCCA 314 AL1-139A AGCGAUAGACCUCGCUGCA AGCGAUAGACCUCGCUGCA 315 AL1-139B UGCAGCGAGGUCUAUCGCU UGCAGCGAGGUCUAUCGCU 316 AL1-140A UAGCGAUAGACCUCGCUGC UAGCGAUAGACCUCGCUGC 317 AL1-140B GCAGCGAGGUCUAUCGCUA GCAGCGAGGUCUAUCGCUA 318 AL1-141A UGGUAGCGAUAGACCUCGC UGGUAGCGAUAGACCUCGC 319 AL1-141B GCGAGGUCUAUCGCUACCA GCGAGGUCUAUCGCUACCA 320 AL1-142A UCACCUGGUAGCGAUAGAC UCACCUGGUAGCGAUAGAC 321 AL1-142B GUCUAUCGCUACCAGGUGA GUCUAUCGCUACCAGGUGA 322 AL1-143A AGCAUGCGUGGCGUCACCU AGCAUGCGUGGCGUCACCU 323 AL1-143B AGGUGACGCCACGCAUGCU AGGUGACGCCACGCAUGCU 324 AL1-144A ACAGCAUGCGUGGCGUCAC ACAGCAUGCGUGGCGUCAC 325 AL1-144B GUGACGCCACGCAUGCUGU GUGACGCCACGCAUGCUGU 326 AL1-145A ACACAGCAUGCGUGGCGUC ACACAGCAUGCGUGGCGUC 327 AL1-145B GACGCCACGCAUGCUGUGU GACGCCACGCAUGCUGUGU 328 AL1-146A AGUUAGGCCGGCCACAGCC AGUUAGGCCGGCCACAGCC 329 AL1-146B GGCUGUGGCCGGCCUAACU GGCUGUGGCCGGCCUAACU 330 AL1-147A UAGUUAGGCCGGCCACAGC UAGUUAGGCCGGCCACAGC 331 AL1-147B GCUGUGGCCGGCCUAACUA GCUGUGGCCGGCCUAACUA 332 AL1-148A AGUAGUUAGGCCGGCCACA AGUAGUUAGGCCGGCCACA 333 AL1-148B UGUGGCCGGCCUAACUACU UGUGGCCGGCCUAACUACU 334 AL1-149A ACGCCGAAGUAGUUAGGCC ACGCCGAAGUAGUUAGGCC 335 AL1-149B GGCCUAACUACUUCGGCGU GGCCUAACUACUUCGGCGU 336 AL1-150A AGACGCCGAAGUAGUUAGG AGACGCCGAAGUAGUUAGG 337 AL1-150B CCUAACUACUUCGGCGUCU CCUAACUACUUCGGCGUCU 338 AL1-151A UAGACGCCGAAGUAGUUAG UAGACGCCGAAGUAGUUAG 339 AL1-151B CUAACUACUUCGGCGUCUA CUAACUACUUCGGCGUCUA 340 AL1-152A UGUAGACGCCGAAGUAGUU UGUAGACGCCGAAGUAGUU 341 AL1-152B AACUACUUCGGCGUCUACA AACUACUUCGGCGUCUACA 342 AL1-153A ACACCUGUGAUGCGGGUGU ACACCUGUGAUGCGGGUGU 343 AL1-153B ACACCCGCAUCACAGGUGU ACACCCGCAUCACAGGUGU 344 AL1-154A UGAUCACACCUGUGAUGCG UGAUCACACCUGUGAUGCG 345 AL1-154B CGCAUCACAGGUGUGAUCA CGCAUCACAGGUGUGAUCA 346 AL1-155A ACCACUUGCUGGAUCCAGC ACCACUUGCUGGAUCCAGC 347 AL1-155B GCUGGAUCCAGCAAGUGGU GCUGGAUCCAGCAAGUGGU 348 AL1-156A UUUGCAGGGGGGCAGUUCC UUUGCAGGGGGGCAGUUCC 349 AL1-156B GGAACUGCCCCCCUGCAAA GGAACUGCCCCCCUGCAAA 350 AL1-157A AGACAAGAUGCCACCUCCU AGACAAGAUGCCACCUCCU 351 AL1-157B AGGAGGUGGCAUCUUGUCU AGGAGGUGGCAUCUUGUCU 352 AL1-158A ACGAGACAAGAUGCCACCU ACGAGACAAGAUGCCACCU 353 AL1-158B AGGUGGCAUCUUGUCUCGU AGGUGGCAUCUUGUCUCGU 354 AL1-159A AGGGACGAGACAAGAUGCC AGGGACGAGACAAGAUGCC 355 AL1-159B GGCAUCUUGUCUCGUCCCU GGCAUCUUGUCUCGUCCCU 356 AL1-160A UCAGGGACGAGACAAGAUG UCAGGGACGAGACAAGAUG 357 AL1-160B CAUCUUGUCUCGUCCCUGA CAUCUUGUCUCGUCCCUGA 358 AL1-161A AUCAGGGACGAGACAAGAU AUCAGGGACGAGACAAGAU 359 AL1-161B AUCUUGUCUCGUCCCUGAU AUCUUGUCUCGUCCCUGAU 360 AL1-162A ACGUCUUGACCCCCAGCUG ACGUCUUGACCCCCAGCUG 361 AL1-162B CAGCUGGGGGUCAAGACGU CAGCUGGGGGUCAAGACGU 362 AL1-163A AGGGGACGUCUUGACCCCC AGGGGACGUCUUGACCCCC 363 AL1-163B GGGGGUCAAGACGUCCCCU GGGGGUCAAGACGUCCCCU 364 AL1-164A UCAGGGGACGUCUUGACCC UCAGGGGACGUCUUGACCC 365 AL1-164B GGGUCAAGACGUCCCCUGA GGGUCAAGACGUCCCCUGA 366 AL1-165A UUGCAUUAGGCAGCAGUGG UUGCAUUAGGCAGCAGUGG 367 AL1-165B CCACUGCUGCCUAAUGCAA CCACUGCUGCCUAAUGCAA 368 AL1-166A UGCCUUGCAUUAGGCAGCA UGCCUUGCAUUAGGCAGCA 369 AL1-166B UGCUGCCUAAUGCAAGGCA UGCUGCCUAAUGCAAGGCA 370 AL1-167A AGCCACUGCCUUGCAUUAG AGCCACUGCCUUGCAUUAG 371 AL1-167B CUAAUGCAAGGCAGUGGCU CUAAUGCAAGGCAGUGGCU 372 AL1-168A AGAACCAGCAUUCUUGCUG AGAACCAGCAUUCUUGCUG 373 AL1-168B CAGCAAGAAUGCUGGUUCU CAGCAAGAAUGCUGGUUCU 374 AL1-169A ACAGAGUGGGGCGCACCUC ACAGAGUGGGGCGCACCUC 375 AL1-169B GAGGUGCGCCCCACUCUGU GAGGUGCGCCCCACUCUGU 376 AL1-170A AGACCAGGGGCUUCCGAAG AGACCAGGGGCUUCCGAAG 377 AL1-170B CUUCGGAAGCCCCUGGUCU CUUCGGAAGCCCCUGGUCU 378 AL1-171A UUAGACCAGGGGCUUCCGA UUAGACCAGGGGCUUCCGA 379 AL1-171B UCGGAAGCCCCUGGUCUAA UCGGAAGCCCCUGGUCUAA 380 AL1-172A AGUUAGACCAGGGGCUUCC AGUUAGACCAGGGGCUUCC 381 AL1-172B GGAAGCCCCUGGUCUAACU GGAAGCCCCUGGUCUAACU 382 AL1-173A AAGUUAGACCAGGGGCUUC AAGUUAGACCAGGGGCUUC 383 AL1-173B GAAGCCCCUGGUCUAACUU GAAGCCCCUGGUCUAACUU 384 AL1-174A AUCCCAAGUUAGACCAGGG AUCCCAAGUUAGACCAGGG 385 AL1-174B CCCUGGUCUAACUUGGGAU CCCUGGUCUAACUUGGGAU 386 AL1-175A AGAUCCCAAGUUAGACCAG AGAUCCCAAGUUAGACCAG 387 AL1-175B CUGGUCUAACUUGGGAUCU CUGGUCUAACUUGGGAUCU 388 AL1-176A UUCCCAGAUCCCAAGUUAG UUCCCAGAUCCCAAGUUAG 389 AL1-176B CUAACUUGGGAUCUGGGAA CUAACUUGGGAUCUGGGAA 390 AL1-177A UGAGGGUCCCCUCCGAUGG UGAGGGUCCCCUCCGAUGG 391 AL1-177B CCAUCGGAGGGGACCCUCA CCAUCGGAGGGGACCCUCA 392 AL1-178A UACAGUGGCAGCAGGCCCA UACAGUGGCAGCAGGCCCA 393 AL1-178B UGGGCCUGCUGCCACUGUA UGGGCCUGCUGCCACUGUA 394 AL1-179A UUACAGUGGCAGCAGGCCC UUACAGUGGCAGCAGGCCC 395 AL1-179B GGGCCUGCUGCCACUGUAA GGGCCUGCUGCCACUGUAA 396 AL1-180A UUUGGCUUACAGUGGCAGC UUUGGCUUACAGUGGCAGC 397 AL1-180B GCUGCCACUGUAAGCCAAA GCUGCCACUGUAAGCCAAA 398 AL1-181A ACCUUUUGGCUUACAGUGG ACCUUUUGGCUUACAGUGG 399 AL1-181B CCACUGUAAGCCAAAAGGU CCACUGUAAGCCAAAAGGU 400 AL1-182A AGUCAGGACUUCCCCACCU AGUCAGGACUUCCCCACCU 401 AL1-182B AGGUGGGGAAGUCCUGACU AGGUGGGGAAGUCCUGACU 402 AL1-183A UGAUCAGGCAGCUUUAUUC UGAUCAGGCAGCUUUAUUC 403 AL1-183B GAAUAAAGCUGCCUGAUCA GAAUAAAGCUGCCUGAUCA 404 AL1-184A UUGAUCAGGCAGCUUUAUU UUGAUCAGGCAGCUUUAUU 405 AL1-184B AAUAAAGCUGCCUGAUCAA AAUAAAGCUGCCUGAUCAA 406 AL1-185A UUUUUUUGAUCAGGCAGCU UUUUUUUGAUCAGGCAGCU 407 AL1-185B AGCUGCCUGAUCAAAAAAA AGCUGCCUGAUCAAAAAAA 408 AL1-186A UUCGUACUCGGCCCUGUAG UUCGUACUCGGCCCUGUAG 409 AL1-186B CUACAGGGCCGAGUACGAA CUACAGGGCCGAGUACGAA 410 AL1-187A AGUCCUUGACCCCAUCACA AGUCCUUGACCCCAUCACA 411 AL1-187B UGUGAUGGGGUCAAGGACU UGUGAUGGGGUCAAGGACU 412 AL1-188A UUGAAGGACACCUCUCCAG UUGAAGGACACCUCUCCAG 413 AL1-188B CUGGAGAGGUGUCCUUCAA CUGGAGAGGUGUCCUUCAA 414 AL1-189A AUACAUGGCCAGUCGGUCC AUACAUGGCCAGUCGGUCC 415 AL1-189B GGACCGACUGGCCAUGUAU GGACCGACUGGCCAUGUAU 416 AL1-190A AGGUCCUGUGGGAUCAACU AGGUCCUGUGGGAUCAACU 417 AL1-190B AGUUGAUCCCACAGGACCU AGUUGAUCCCACAGGACCU 418 AL1-191A UUCUGGGCUUUGGCGGUUU UUCUGGGCUUUGGCGGUUU 419 AL1-191B AAACCGCCAAAGCCCAGAA AAACCGCCAAAGCCCAGAA 420 AL1-192A UUGCGGUAGCCGGCACACA UUGCGGUAGCCGGCACACA 421 AL1-192B UGUGUGCCGGCUACCGCAA UGUGUGCCGGCUACCGCAA 422 AL1-193A UAACAACCCAGCGUGGAAU UAACAACCCAGCGUGGAAU 423 AL1-193B AUUCCACGCUGGGUUGUUA AUUCCACGCUGGGUUGUUA 424 AL1-194A AUCACCCAGCGGUCAGCGA AUCACCCAGCGGUCAGCGA 425 AL1-194B UCGCUGACCGCUGGGUGAU UCGCUGACCGCUGGGUGAU 426 AL1-195A AUACUUGUCCCCCUGCUUG AUACUUGUCCCCCUGCUUG 427 AL1-195B CAAGCAGGGGGACAAGUAU CAAGCAGGGGGACAAGUAU 428 AL1-196A AUCACUGGAGCAGACAUCA AUCACUGGAGCAGACAUCA 429 AL1-196B UGAUGUCUGCUCCAGUGAU UGAUGUCUGCUCCAGUGAU 430 AL1-197A UCACCUUGAAGGACACCUC UCACCUUGAAGGACACCUC 431 AL1-197B GAGGUGUCCUUCAAGGUGA GAGGUGUCCUUCAAGGUGA 432 AL1-198A AAUACUUGUCCCCCUGCUU AAUACUUGUCCCCCUGCUU 433 AL1-198B AAGCAGGGGGACAAGUAUU AAGCAGGGGGACAAGUAUU 434 AL1-199A UCCAUUCCCAGAUCCCAAG UCCAUUCCCAGAUCCCAAG 435 AL1-199B CUUGGGAUCUGGGAAUGGA CUUGGGAUCUGGGAAUGGA 436 AL1-200A UUGUACCCUAGGAAAUACC UUGUACCCUAGGAAAUACC 437 AL1-200B GGUAUUUCCUAGGGUACAA GGUAUUUCCUAGGGUACAA 438 AL1-201A UCUUGCCCUUGCGGUAGCC UCUUGCCCUUGCGGUAGCC 439 AL1-201B GGCUACCGCAAGGGCAAGA GGCUACCGCAAGGGCAAGA 440 AL1-202A AGAAUACUUGUCCCCCUGC AGAAUACUUGUCCCCCUGC 441 AL1-202B GCAGGGGGACAAGUAUUCU GCAGGGGGACAAGUAUUCU 442 AL1-203A AGCAUUCUUGCUGCUGAGC AGCAUUCUUGCUGCUGAGC 443 AL1-203B GCUCAGCAGCAAGAAUGCU GCUCAGCAGCAAGAAUGCU 444 AL1-204A UUCCAUUCCCAGAUCCCAA UUCCAUUCCCAGAUCCCAA 445 AL1-204B UUGGGAUCUGGGAAUGGAA UUGGGAUCUGGGAAUGGAA 446 AL1-205A AGCAUCUUCUGGGCUUUGG AGCAUCUUCUGGGCUUUGG 447 AL1-205B CCAAAGCCCAGAAGAUGCU CCAAAGCCCAGAAGAUGCU 448 AL1-206A UUCUUGCCCUUGCGGUAGC UUCUUGCCCUUGCGGUAGC 449 AL1-206B GCUACCGCAAGGGCAAGAA GCUACCGCAAGGGCAAGAA 450 AL1-207A UUCCAAAGGGCAGCUGAGC UUCCAAAGGGCAGCUGAGC 451 AL1-207B GCUCAGCUGCCCUUUGGAA GCUCAGCUGCCCUUUGGAA 452 AL1-208A AUGCCACCUCCUGCCACCA AUGCCACCUCCUGCCACCA 453 AL1-208B UGGUGGCAGGAGGUGGCAU UGGUGGCAGGAGGUGGCAU 454 AL1-209A AGCCUCUGUACAGAGUGGG AGCCUCUGUACAGAGUGGG 455 AL1-209B CCCACUCUGUACAGAGGCU CCCACUCUGUACAGAGGCU 456 AL1-210A UGAGGGUCUGGGCUGUGAG UGAGGGUCUGGGCUGUGAG 457 AL1-210B CUCACAGCCCAGACCCUCA CUCACAGCCCAGACCCUCA 458 AL1-211A AAGCCGUAGUCCAGAGAGG AAGCCGUAGUCCAGAGAGG 459 AL1-211B CCUCUCUGGACUACGGCUU CCUCUCUGGACUACGGCUU 460 AL1-212A AGAUGCCACCUCCUGCCAC AGAUGCCACCUCCUGCCAC 461 AL1-212B GUGGCAGGAGGUGGCAUCU GUGGCAGGAGGUGGCAUCU 462 AL1-213A UAGACCAGGGGCUUCCGAA UAGACCAGGGGCUUCCGAA 463 AL1-213B UUCGGAAGCCCCUGGUCUA UUCGGAAGCCCCUGGUCUA 464 AL1-214A UCCAAAGGGCAGCUGAGCU UCCAAAGGGCAGCUGAGCU 465 AL1-214B AGCUCAGCUGCCCUUUGGA AGCUCAGCUGCCCUUUGGA 466 AL1-215A AGUUUCUCUCAUCCAGGCC AGUUUCUCUCAUCCAGGCC 467 AL1-215B GGCCUGGAUGAGAGAAACU GGCCUGGAUGAGAGAAACU 468 AL1-216A AAGAUGCCACCUCCUGCCA AAGAUGCCACCUCCUGCCA 469 AL1-216B UGGCAGGAGGUGGCAUCUU UGGCAGGAGGUGGCAUCUU 470 AL1-217A UGGAGGCCACAGUCACAGU UGGAGGCCACAGUCACAGU 471 AL1-217B ACUGUGACUGUGGCCUCCA ACUGUGACUGUGGCCUCCA 472 AL1-218A UCCCAAGUUAGACCAGGGG UCCCAAGUUAGACCAGGGG 473 AL1-218B CCCCUGGUCUAACUUGGGA CCCCUGGUCUAACUUGGGA 474 AL1-219A UAUUCCAAAGGGCAGCUGA UAUUCCAAAGGGCAGCUGA 475 AL1-219B UCAGCUGCCCUUUGGAAUA UCAGCUGCCCUUUGGAAUA 476 AL1-220A ACAGAUGUGUCGACCCCGA ACAGAUGUGUCGACCCCGA 477 AL1-220B UCGGGGUCGACACAUCUGU UCGGGGUCGACACAUCUGU 478 AL1-221A UGGAGCAGACAUCAGGGAC UGGAGCAGACAUCAGGGAC 479 AL1-221B GUCCCUGAUGUCUGCUCCA GUCCCUGAUGUCUGCUCCA 480 AL1-222A ACCCAGCGGUCAGCGAUGA ACCCAGCGGUCAGCGAUGA 481 AL1-222B UCAUCGCUGACCGCUGGGU UCAUCGCUGACCGCUGGGU 482 AL1-223A UUAUUCCAAAGGGCAGCUG UUAUUCCAAAGGGCAGCUG 483 AL2-1A UUGAAGGACACCUCUCCAGGCCA UUGAAGGACACCUCUCCAGGCCA 484 AL2-1B UGGCCUGGAGAGGUGUCCUUC UGGCCUGGAGAGGUGUCCUUC 485 AL2-2A AGGAAAUACCAGAGUAGCACCCC AGGAAAUACCAGAGUAGCACCCC 486 AL2-2B GGGGUGCUACUCUGGUAUUUC GGGGUGCUACUCUGGUAUUUC 487 AL2-3A AGUUUCUCUCAUCCAGGCCGUUG AGUUUCUCUCAUCCAGGCCGUUG 488 AL2-3B CAACGGCCUGGAUGAGAGAAA CAACGGCCUGGAUGAGAGAAA 489 AL2-4A AAGAUCCUGGGAGAAGUGGCGAU AAGAUCCUGGGAGAAGUGGCGAU 490 AL2-4B AUCGCCACUUCUCCCAGGAUC AUCGCCACUUCUCCCAGGAUC 491 AL2-5A ACAAGAUGCCACCUCCUGCCACC ACAAGAUGCCACCUCCUGCCACC 492 AL2-5B GGUGGCAGGAGGUGGCAUCUU GGUGGCAGGAGGUGGCAUCUU 493 AL2-6A ACGUCAUACAUGGCCAGUCGGUC ACGUCAUACAUGGCCAGUCGGUC 494 AL2-6B GACCGACUGGCCAUGUAUGAC GACCGACUGGCCAUGUAUGAC 495 AL2-7A AAGCCAUAGUGCACCCGCACACC AAGCCAUAGUGCACCCGCACACC 496 AL2-7B GGUGUGCGGGUGCACUAUGGC GGUGUGCGGGUGCACUAUGGC 497 AL2-8A ACGCAGUUUCUCUCAUCCAGGCC ACGCAGUUUCUCUCAUCCAGGCC 498 AL2-8B GGCCUGGAUGAGAGAAACUGC GGCCUGGAUGAGAGAAACUGC 499 AL2-9A UUGUACCCUAGGAAAUACCAGAG UUGUACCCUAGGAAAUACCAGAG 500 AL2-9B CUCUGGUAUUUCCUAGGGUAC CUCUGGUAUUUCCUAGGGUAC 501 AL2-10A AGAUCCCAAGUUAGACCAGGGGC AGAUCCCAAGUUAGACCAGGGGC 502 AL2-10B GCCCCUGGUCUAACUUGGGAU GCCCCUGGUCUAACUUGGGAU 503 AL2-11A ACGGCAAAUCAUACUUCUGCCUC ACGGCAAAUCAUACUUCUGCCUC 504 AL2-11B GAGGCAGAAGUAUGAUUUGCC GAGGCAGAAGUAUGAUUUGCC 505 AL2-12A AGCUAUGUCUUUCACACUGGCUU AGCUAUGUCUUUCACACUGGCUU 506 AL2-12B AAGCCAGUGUGAAAGACAUAG AAGCCAGUGUGAAAGACAUAG 507 AL2-13A AUACAUGGCCAGUCGGUCCCGGC AUACAUGGCCAGUCGGUCCCGGC 508 AL2-13B GCCGGGACCGACUGGCCAUGU GCCGGGACCGACUGGCCAUGU 509 AL2-14A AUGUGUCGACCCCGAACCUGGAG AUGUGUCGACCCCGAACCUGGAG 510 AL2-14B CUCCAGGUUCGGGGUCGACAC CUCCAGGUUCGGGGUCGACAC 511 AL2-15A GAUCCCAAGUUAGACCAGGGGCU GAUCCCAAGUUAGACCAGGGGCU 512 AL2-15B AGCCCCUGGUCUAACUUGGGA AGCCCCUGGUCUAACUUGGGA 513 AL2-16A UAAGAUCCUGGGAGAAGUGGCGA UAAGAUCCUGGGAGAAGUGGCGA 514 AL2-16B UCGCCACUUCUCCCAGGAUCU UCGCCACUUCUCCCAGGAUCU 515 AL2-17A UGUACCCUAGGAAAUACCAGAGU UGUACCCUAGGAAAUACCAGAGU 516 AL2-17B ACUCUGGUAUUUCCUAGGGUA ACUCUGGUAUUUCCUAGGGUA 517 AL2-18A UGUUAUCACCCAGCGGUCAGCGA UGUUAUCACCCAGCGGUCAGCGA 518 AL2-18B UCGCUGACCGCUGGGUGAUAA UCGCUGACCGCUGGGUGAUAA 519 AL2-19A UCUCUCAUCCAGGCCGUUGGGGC UCUCUCAUCCAGGCCGUUGGGGC 520 AL2-19B GCCCCAACGGCCUGGAUGAGA GCCCCAACGGCCUGGAUGAGA 521 AL2-20A GAAUACUUGUCCCCCUGCUUGGC GAAUACUUGUCCCCCUGCUUGGC 522 AL2-20B GCCAAGCAGGGGGACAAGUAU GCCAAGCAGGGGGACAAGUAU 523 AL2-21A UUCGUACUCGGCCCUGUAGGGGA UUCGUACUCGGCCCUGUAGGGGA 524 AL2-21B UCCCCUACAGGGCCGAGUACG UCCCCUACAGGGCCGAGUACG 525 AL2-22A UAGCUGUAGCGGUAACAACCCAG UAGCUGUAGCGGUAACAACCCAG 526 AL2-22B CUGGGUUGUUACCGCUACAGC CUGGGUUGUUACCGCUACAGC 527 AL2-23A UGAAGGACACCUCUCCAGGCCAG UGAAGGACACCUCUCCAGGCCAG 528 AL2-23B CUGGCCUGGAGAGGUGUCCUU CUGGCCUGGAGAGGUGUCCUU 529 AL2-24A UACAAGCCAUAGUGCACCCGCAC UACAAGCCAUAGUGCACCCGCAC 530 AL2-24B GUGCGGGUGCACUAUGGCUUG GUGCGGGUGCACUAUGGCUUG 531 AL2-25A AGACAAGAUGCCACCUCCUGCCA AGACAAGAUGCCACCUCCUGCCA 532 AL2-25B UGGCAGGAGGUGGCAUCUUGU UGGCAGGAGGUGGCAUCUUGU 533 AL2-26A ACUUCGUACUCGGCCCUGUAGGG ACUUCGUACUCGGCCCUGUAGGG 534 AL2-26B CCCUACAGGGCCGAGUACGAA CCCUACAGGGCCGAGUACGAA 535 AL2-27A AGAAUGAACCAGAAGAAGCAGGU AGAAUGAACCAGAAGAAGCAGGU 536 AL2-27B ACCUGCUUCUUCUGGUUCAUU ACCUGCUUCUUCUGGUUCAUU 537 AL2-28A AGUCCUUGACCCCAUCACAGGCA AGUCCUUGACCCCAUCACAGGCA 538 AL2-28B UGCCUGUGAUGGGGUCAAGGA UGCCUGUGAUGGGGUCAAGGA 539 AL2-29A UAGACCAGGGGCUUCCGAAGCUG UAGACCAGGGGCUUCCGAAGCUG 540 AL2-29B CAGCUUCGGAAGCCCCUGGUC CAGCUUCGGAAGCCCCUGGUC 541 AL2-30A CAGAUCCCAAGUUAGACCAGGGG CAGAUCCCAAGUUAGACCAGGGG 542 AL2-30B CCCCUGGUCUAACUUGGGAUC CCCCUGGUCUAACUUGGGAUC 543 AL2-31A UGGAGAAUGAACCAGAAGAAGCA UGGAGAAUGAACCAGAAGAAGCA 544 AL2-31B UGCUUCUUCUGGUUCAUUCUC UGCUUCUUCUGGUUCAUUCUC 545 AL2-32A UUUCUCUCAUCCAGGCCGUUGGG UUUCUCUCAUCCAGGCCGUUGGG 546 AL2-32B CCCAACGGCCUGGAUGAGAGA CCCAACGGCCUGGAUGAGAGA 547 AL2-33A UCGUAGUAGCUGUGCAGGCCCUU UCGUAGUAGCUGUGCAGGCCCUU 548 AL2-33B AAGGGCCUGCACAGCUACUAC AAGGGCCUGCACAGCUACUAC 549 AL2-34A CAUUCCCAGAUCCCAAGUUAGAC CAUUCCCAGAUCCCAAGUUAGAC 550 AL2-34B GUCUAACUUGGGAUCUGGGAA GUCUAACUUGGGAUCUGGGAA 551 AL2-35A UUAGACCAGGGGCUUCCGAAGCU UUAGACCAGGGGCUUCCGAAGCU 552 AL2-35B AGCUUCGGAAGCCCCUGGUCU AGCUUCGGAAGCCCCUGGUCU 553 AL2-36A UGCAGCUAUGUCUUUCACACUGG UGCAGCUAUGUCUUUCACACUGG 554 AL2-36B CCAGUGUGAAAGACAUAGCUG CCAGUGUGAAAGACAUAGCUG 555 AL2-37A AGAUGUGUCGACCCCGAACCUGG AGAUGUGUCGACCCCGAACCUGG 556 AL2-37B CCAGGUUCGGGGUCGACACAU CCAGGUUCGGGGUCGACACAU 557 AL2-38A UAGCGGUAACAACCCAGCGUGGA UAGCGGUAACAACCCAGCGUGGA 558 AL2-38B UCCACGCUGGGUUGUUACCGC UCCACGCUGGGUUGUUACCGC 559 AL2-39A AAUACUUGUCCCCCUGCUUGGCA AAUACUUGUCCCCCUGCUUGGCA 560 AL2-39B UGCCAAGCAGGGGGACAAGUA UGCCAAGCAGGGGGACAAGUA 561 AL2-40A CCACACAGCCUCCUGUUCUGGAU CCACACAGCCUCCUGUUCUGGAU 562 AL2-40B AUCCAGAACAGGAGGCUGUGU AUCCAGAACAGGAGGCUGUGU 563 AL2-41A GUGAGGGAGAUCUGGGAGGUGAA GUGAGGGAGAUCUGGGAGGUGAA 564 AL2-41B UUCACCUCCCAGAUCUCCCUC UUCACCUCCCAGAUCUCCCUC 565 AL2-42A CCAUGGCCACUCACCCUCGGAGG CCAUGGCCACUCACCCUCGGAGG 566 AL2-42B CCUCCGAGGGUGAGUGGCCAU CCUCCGAGGGUGAGUGGCCAU 567 AL2-43A GCCACACAGCCUCCUGUUCUGGA GCCACACAGCCUCCUGUUCUGGA 568 AL2-43B UCCAGAACAGGAGGCUGUGUG UCCAGAACAGGAGGCUGUGUG 569 AL2-44A GGCCACUCACCCUCGGAGGACAC GGCCACUCACCCUCGGAGGACAC 570 AL2-44B GUGUCCUCCGAGGGUGAGUGG GUGUCCUCCGAGGGUGAGUGG 571 AL2-45A CCCACAGAUGUGUCGACCCCGAA CCCACAGAUGUGUCGACCCCGAA 572 AL2-45B UUCGGGGUCGACACAUCUGUG UUCGGGGUCGACACAUCUGUG 573 AL2-46A CCCCACAGAUGUGUCGACCCCGA CCCCACAGAUGUGUCGACCCCGA 574 AL2-46B UCGGGGUCGACACAUCUGUGG UCGGGGUCGACACAUCUGUGG 575 AL2-47A GCCAUGCUGUCCUCCUGGAAGCA GCCAUGCUGUCCUCCUGGAAGCA 576 AL2-47B UGCUUCCAGGAGGACAGCAUG UGCUUCCAGGAGGACAGCAUG 577 AL2-48A UGUACCCUAGGAAAUACCAGAGU UGUACCCUAGGAAAUACCAGAGU 578 AL2-48B UCUGGUAUUUCCUAGGGUACA UCUGGUAUUUCCUAGGGUACA 579 AL2-49A AGGAAAUACCAGAGUAGCACCCC AGGAAAUACCAGAGUAGCACCCC 580 AL2-49B GGUGCUACUCUGGUAUUUCCU GGUGCUACUCUGGUAUUUCCU 581 AL2-50A UGUACCCUAGGAAAUACCAGAGU UGUACCCUAGGAAAUACCAGAGU 582 AL2-50B UCUGGUAUUUCCUAGGGUACA UCUGGUAUUUCCUAGGGUACA 583 AL2-51A UUGUACCCUAGGAAAUACCAGAG UUGUACCCUAGGAAAUACCAGAG 584 AL2-51B CUGGUAUUUCCUAGGGUACAA CUGGUAUUUCCUAGGGUACAA 585 AL2-52A UUUGUACCCUAGGAAAUACCAGA UUUGUACCCUAGGAAAUACCAGA 586 AL2-52B UGGUAUUUCCUAGGGUACAAA UGGUAUUUCCUAGGGUACAAA 587 AL2-53A UCUUGUACCCUAGGAAAUACCAG UCUUGUACCCUAGGAAAUACCAG 588 AL2-53B GGUAUUUCCUAGGGUACAAGA GGUAUUUCCUAGGGUACAAGA 589 AL2-54A UGUACCCUAGGAAAUACCA UGUACCCUAGGAAAUACCA 590 AL2-54B UGGUAUUUCCUAGGGUACA UGGUAUUUCCUAGGGUACA 591 AL2-55A UCCUUGUACCCUAGGAAAUACCA UCCUUGUACCCUAGGAAAUACCA 592 AL2-55B GUAUUUCCUAGGGUACAAGGA GUAUUUCCUAGGGUACAAGGA 593 AL2-56A UCGCCUUGUACCCUAGGAAAUAC UCGCCUUGUACCCUAGGAAAUAC 594 AL2-56B AUUUCCUAGGGUACAAGGCGA AUUUCCUAGGGUACAAGGCGA 595 AL2-57A UCCGCCUUGUACCCUAGGAAAUA UCCGCCUUGUACCCUAGGAAAUA 596 AL2-57B UUUCCUAGGGUACAAGGCGGA UUUCCUAGGGUACAAGGCGGA 597 AL2-58A AAGAUCCUGGGAGAAGUGGCGAU AAGAUCCUGGGAGAAGUGGCGAU 598 AL2-58B CGCCACUUCUCCCAGGAUCUU CGCCACUUCUCCCAGGAUCUU 599 AL2-59A UAAGAUCCUGGGAGAAGUGGCGA UAAGAUCCUGGGAGAAGUGGCGA 600 AL2-59B GCCACUUCUCCCAGGAUCUUA GCCACUUCUCCCAGGAUCUUA 601 AL2-60A AGAAUGAACCAGAAGAAGCAGGU AGAAUGAACCAGAAGAAGCAGGU 602 AL2-60B CUGCUUCUUCUGGUUCAUUCU CUGCUUCUUCUGGUUCAUUCU 603 AL2-61A UGGAGAAUGAACCAGAAGAAGCA UGGAGAAUGAACCAGAAGAAGCA 604 AL2-61B CUUCUUCUGGUUCAUUCUCCA CUUCUUCUGGUUCAUUCUCCA 605 AL2-62A UUCGUACUCGGCCCUGUAGGGGA UUCGUACUCGGCCCUGUAGGGGA 606 AL2-62B CCCUACAGGGCCGAGUACGAA CCCUACAGGGCCGAGUACGAA 607 AL2-63A ACUUCGUACUCGGCCCUGUAGGG ACUUCGUACUCGGCCCUGUAGGG 608 AL2-63B CUACAGGGCCGAGUACGAAGU CUACAGGGCCGAGUACGAAGU 609 AL2-64A AGCUAUGUCUUUCACACUGGCUU AGCUAUGUCUUUCACACUGGCUU 610 AL2-64B GCCAGUGUGAAAGACAUAGCU GCCAGUGUGAAAGACAUAGCU 611 AL2-65A UGCAGCUAUGUCUUUCACACUGG UGCAGCUAUGUCUUUCACACUGG 612 AL2-65B AGUGUGAAAGACAUAGCUGCA AGUGUGAAAGACAUAGCUGCA 613 AL2-66A UAGCGGUAACAACCCAGCGUGGA UAGCGGUAACAACCCAGCGUGGA 614 AL2-66B CACGCUGGGUUGUUACCGCUA CACGCUGGGUUGUUACCGCUA 615 AL2-67A UAGCUGUAGCGGUAACAACCCAG UAGCUGUAGCGGUAACAACCCAG 616 AL2-67B GGGUUGUUACCGCUACAGCUA GGGUUGUUACCGCUACAGCUA 617 AL2-68A AUACAUGGCCAGUCGGUCCCGGC AUACAUGGCCAGUCGGUCCCGGC 618 AL2-68B CGGGACCGACUGGCCAUGUAU CGGGACCGACUGGCCAUGUAU 619 AL2-69A ACGUCAUACAUGGCCAGUCGGUC ACGUCAUACAUGGCCAGUCGGUC 620 AL2-69B CCGACUGGCCAUGUAUGACGU CCGACUGGCCAUGUAUGACGU 621 AL2-70A UCGUAGUAGCUGUGCAGGCCCUU UCGUAGUAGCUGUGCAGGCCCUU 622 AL2-70B GGGCCUGCACAGCUACUACGA GGGCCUGCACAGCUACUACGA 623 AL2-71A ACGGCAAAUCAUACUUCUGCCUC ACGGCAAAUCAUACUUCUGCCUC 624 AL2-71B GGCAGAAGUAUGAUUUGCCGU GGCAGAAGUAUGAUUUGCCGU 625 AL2-72A CCACACAGCCUCCUGUUCUGGAU CCACACAGCCUCCUGUUCUGGAU 626 AL2-72B CCAGAACAGGAGGCUGUGUGG CCAGAACAGGAGGCUGUGUGG 627 AL2-73A GCCACACAGCCUCCUGUUCUGGA GCCACACAGCCUCCUGUUCUGGA 628 AL2-73B CAGAACAGGAGGCUGUGUGGC CAGAACAGGAGGCUGUGUGGC 629 AL2-74A GUGAGGGAGAUCUGGGAGGUGAA GUGAGGGAGAUCUGGGAGGUGAA 630 AL2-74B CACCUCCCAGAUCUCCCUCAC CACCUCCCAGAUCUCCCUCAC 631 AL2-75A UUGAGGGAGAUCUGGGAGGUGAA UUGAGGGAGAUCUGGGAGGUGAA 632 AL2-75B CACCUCCCAGAUCUCCCUCAA CACCUCCCAGAUCUCCCUCAA 633 AL2-76A AAGCCAUAGUGCACCCGCACACC AAGCCAUAGUGCACCCGCACACC 634 AL2-76B UGUGCGGGUGCACUAUGGCUU UGUGCGGGUGCACUAUGGCUU 635 AL2-77A UACAAGCCAUAGUGCACCCGCAC UACAAGCCAUAGUGCACCCGCAC 636 AL2-77B GCGGGUGCACUAUGGCUUGUA GCGGGUGCACUAUGGCUUGUA 637 AL2-78A AGGAACUCUCCAGGGCAGGGGUC AGGAACUCUCCAGGGCAGGGGUC 638 AL2-78B CCCCUGCCCUGGAGAGUUCCU CCCCUGCCCUGGAGAGUUCCU 639 AL2-79A UAGGAACUCUCCAGGGCAGGGGU UAGGAACUCUCCAGGGCAGGGGU 640 AL2-79B CCCUGCCCUGGAGAGUUCCUA CCCUGCCCUGGAGAGUUCCUA 641 AL2-80A AGAGGAACUCUCCAGGGCAGGGG AGAGGAACUCUCCAGGGCAGGGG 642 AL2-80B CCUGCCCUGGAGAGUUCCUCU CCUGCCCUGGAGAGUUCCUCU 643 AL2-81A UAGAGGAACUCUCCAGGGCAGGG UAGAGGAACUCUCCAGGGCAGGG 644 AL2-81B CUGCCCUGGAGAGUUCCUCUA CUGCCCUGGAGAGUUCCUCUA 645 AL2-82A AGUCCUUGACCCCAUCACAGGCA AGUCCUUGACCCCAUCACAGGCA 646 AL2-82B CCUGUGAUGGGGUCAAGGACU CCUGUGAUGGGGUCAAGGACU 647 AL2-83A UCCAGGCCGUUGGGGCAGUCCUU UCCAGGCCGUUGGGGCAGUCCUU 648 AL2-83B GGACUGCCCCAACGGCCUGGA GGACUGCCCCAACGGCCUGGA 649 AL2-84A UAUCCAGGCCGUUGGGGCAGUCC UAUCCAGGCCGUUGGGGCAGUCC 650 AL2-84B ACUGCCCCAACGGCCUGGAUA ACUGCCCCAACGGCCUGGAUA 651 AL2-85A UCAUCCAGGCCGUUGGGGCAGUC UCAUCCAGGCCGUUGGGGCAGUC 652 AL2-85B CUGCCCCAACGGCCUGGAUGA CUGCCCCAACGGCCUGGAUGA 653 AL2-86A UUCAUCCAGGCCGUUGGGGCAGU UUCAUCCAGGCCGUUGGGGCAGU 654 AL2-86B UGCCCCAACGGCCUGGAUGAA UGCCCCAACGGCCUGGAUGAA 655 AL2-87A UCUCAUCCAGGCCGUUGGGGCAG UCUCAUCCAGGCCGUUGGGGCAG 656 AL2-87B GCCCCAACGGCCUGGAUGAGA GCCCCAACGGCCUGGAUGAGA 657 AL2-88A UUCUCAUCCAGGCCGUUGGGGCA UUCUCAUCCAGGCCGUUGGGGCA 658 AL2-88B CCCCAACGGCCUGGAUGAGAA CCCCAACGGCCUGGAUGAGAA 659 AL2-89A UCUCUCAUCCAGGCCGUUGGGGC UCUCUCAUCCAGGCCGUUGGGGC 660 AL2-89B CCCAACGGCCUGGAUGAGAGA CCCAACGGCCUGGAUGAGAGA 661 AL2-90A UUUCUCUCAUCCAGGCCGUUGGG UUUCUCUCAUCCAGGCCGUUGGG 662 AL2-90B CAACGGCCUGGAUGAGAGAAA CAACGGCCUGGAUGAGAGAAA 663 AL2-91A AGUUUCUCUCAUCCAGGCCGUUG AGUUUCUCUCAUCCAGGCCGUUG 664 AL2-91B ACGGCCUGGAUGAGAGAAACU ACGGCCUGGAUGAGAGAAACU 665 AL2-92A ACGCAGUUUCUCUCAUCCAGGCC ACGCAGUUUCUCUCAUCCAGGCC 666 AL2-92B CCUGGAUGAGAGAAACUGCGU CCUGGAUGAGAGAAACUGCGU 667 AL2-93A UUGGAGGCCACAGUCACAGUGCU UUGGAGGCCACAGUCACAGUGCU 668 AL2-93B CACUGUGACUGUGGCCUCCAA CACUGUGACUGUGGCCUCCAA 669 AL2-94A GGCCACUCACCCUCGGAGGACAC GGCCACUCACCCUCGGAGGACAC 670 AL2-94B GUCCUCCGAGGGUGAGUGGCC GUCCUCCGAGGGUGAGUGGCC 671 AL2-95A UAUGGCCACUCACCCUCGGAGGA UAUGGCCACUCACCCUCGGAGGA 672 AL2-95B CUCCGAGGGUGAGUGGCCAUA CUCCGAGGGUGAGUGGCCAUA 673 AL2-96A CCAUGGCCACUCACCCUCGGAGG CCAUGGCCACUCACCCUCGGAGG 674 AL2-96B UCCGAGGGUGAGUGGCCAUGG UCCGAGGGUGAGUGGCCAUGG 675 AL2-97A AUGUGUCGACCCCGAACCUGGAG AUGUGUCGACCCCGAACCUGGAG 676 AL2-97B CCAGGUUCGGGGUCGACACAU CCAGGUUCGGGGUCGACACAU 677 AL2-98A AGAUGUGUCGACCCCGAACCUGG AGAUGUGUCGACCCCGAACCUGG 678 AL2-98B AGGUUCGGGGUCGACACAUCU AGGUUCGGGGUCGACACAUCU 679 AL2-99A CCCACAGAUGUGUCGACCCCGAA CCCACAGAUGUGUCGACCCCGAA 680 AL2-99B CGGGGUCGACACAUCUGUGGG CGGGGUCGACACAUCUGUGGG 681 AL2-100A UCCACAGAUGUGUCGACCCCGAA UCCACAGAUGUGUCGACCCCGAA 682 AL2-100B CGGGGUCGACACAUCUGUGGA CGGGGUCGACACAUCUGUGGA 683 AL2-101A CCCCACAGAUGUGUCGACCCCGA CCCCACAGAUGUGUCGACCCCGA 684 AL2-101B GGGGUCGACACAUCUGUGGGG GGGGUCGACACAUCUGUGGGG 685 AL2-102A UCCCACAGAUGUGUCGACCCCGA UCCCACAGAUGUGUCGACCCCGA 686 AL2-102B GGGGUCGACACAUCUGUGGGA GGGGUCGACACAUCUGUGGGA 687 AL2-103A UCCCCACAGAUGUGUCGACCCCG UCCCCACAGAUGUGUCGACCCCG 688 AL2-103B GGGUCGACACAUCUGUGGGGA GGGUCGACACAUCUGUGGGGA 689 AL2-104A UGUUAUCACCCAGCGGUCAGCGA UGUUAUCACCCAGCGGUCAGCGA 690 AL2-104B GCUGACCGCUGGGUGAUAACA GCUGACCGCUGGGUGAUAACA 691 AL2-105A GCCAUGCUGUCCUCCUGGAAGCA GCCAUGCUGUCCUCCUGGAAGCA 692 AL2-105B CUUCCAGGAGGACAGCAUGGC CUUCCAGGAGGACAGCAUGGC 693 AL2-106A UGAAGGACACCUCUCCAGGCCAG UGAAGGACACCUCUCCAGGCCAG 694 AL2-106B GGCCUGGAGAGGUGUCCUUCA GGCCUGGAGAGGUGUCCUUCA 695 AL2-107A UUGAAGGACACCUCUCCAGGCCA UUGAAGGACACCUCUCCAGGCCA 696 AL2-107B GCCUGGAGAGGUGUCCUUCAA GCCUGGAGAGGUGUCCUUCAA 697 AL2-108A AAUACUUGUCCCCCUGCUUGGCA AAUACUUGUCCCCCUGCUUGGCA 698 AL2-108B CCAAGCAGGGGGACAAGUAUU CCAAGCAGGGGGACAAGUAUU 699 AL2-109A GAAUACUUGUCCCCCUGCUUGGC GAAUACUUGUCCCCCUGCUUGGC 700 AL2-109B CAAGCAGGGGGACAAGUAUUC CAAGCAGGGGGACAAGUAUUC 701 AL2-110A ACAAGAUGCCACCUCCUGCCACC ACAAGAUGCCACCUCCUGCCACC 702 AL2-110B UGGCAGGAGGUGGCAUCUUGU UGGCAGGAGGUGGCAUCUUGU 703 AL2-111A AGACAAGAUGCCACCUCCUGCCA AGACAAGAUGCCACCUCCUGCCA 704 AL2-111B GCAGGAGGUGGCAUCUUGUCU GCAGGAGGUGGCAUCUUGUCU 705 AL2-112A UAGACCAGGGGCUUCCGAAGCUG UAGACCAGGGGCUUCCGAAGCUG 706 AL2-112B GCUUCGGAAGCCCCUGGUCUA GCUUCGGAAGCCCCUGGUCUA 707 AL2-113A UUAGACCAGGGGCUUCCGAAGCU UUAGACCAGGGGCUUCCGAAGCU 708 AL2-113B CUUCGGAAGCCCCUGGUCUAA CUUCGGAAGCCCCUGGUCUAA 709 AL2-114A GAUCCCAAGUUAGACCAGGGGCU GAUCCCAAGUUAGACCAGGGGCU 710 AL2-114B CCCCUGGUCUAACUUGGGAUC CCCCUGGUCUAACUUGGGAUC 711 AL2-115A AGAUCCCAAGUUAGACCAGGGGC AGAUCCCAAGUUAGACCAGGGGC 712 AL2-115B CCCUGGUCUAACUUGGGAUCU CCCUGGUCUAACUUGGGAUCU 713 AL2-116A CAGAUCCCAAGUUAGACCAGGGG CAGAUCCCAAGUUAGACCAGGGG 714 AL2-116B CCUGGUCUAACUUGGGAUCUG CCUGGUCUAACUUGGGAUCUG 715 AL2-117A CAUUCCCAGAUCCCAAGUUAGAC CAUUCCCAGAUCCCAAGUUAGAC 716 AL2-117B CUAACUUGGGAUCUGGGAAUG CUAACUUGGGAUCUGGGAAUG 717 AL2-118A CUGGACUGGGUCUGGCUCA CUGGACUGGGUCUGGCUCA 718 AL2-118B UGAGCCAGACCCAGUCCAG UGAGCCAGACCCAGUCCAG 719 AL2-119A ACCAGAGCUGGACUGGGUC ACCAGAGCUGGACUGGGUC 720 AL2-119B GACCCAGUCCAGCUCUGGU GACCCAGUCCAGCUCUGGU 721 AL2-120A CAGAGGGCAGGCACCAGAG CAGAGGGCAGGCACCAGAG 722 AL2-120B CUCUGGUGCCUGCCCUCUG CUCUGGUGCCUGCCCUCUG 723 AL2-121A UCAGCUCGCACCAGAGGGC UCAGCUCGCACCAGAGGGC 724 AL2-121B GCCCUCUGGUGCGAGCUGA GCCCUCUGGUGCGAGCUGA 725 AL2-122A UCUCAGGUCAGCUCGCACC UCUCAGGUCAGCUCGCACC 726 AL2-122B GGUGCGAGCUGACCUGAGA GGUGCGAGCUGACCUGAGA 727 AL2-123A GGAAGUGCAUCUCAGGUCA GGAAGUGCAUCUCAGGUCA 728 AL2-123B UGACCUGAGAUGCACUUCC UGACCUGAGAUGCACUUCC 729 AL2-124A CACAGAGGAGGGAAGUGCA CACAGAGGAGGGAAGUGCA 730 AL2-124B UGCACUUCCCUCCUCUGUG UGCACUUCCCUCCUCUGUG 731 AL2-125A GUGCCGAGACAGCUCACAG GUGCCGAGACAGCUCACAG 732 AL2-125B CUGUGAGCUGUCUCGGCAC CUGUGAGCUGUCUCGGCAC 733 AL2-126A UGCAAGUGGGUGCCGAGAC UGCAAGUGGGUGCCGAGAC 734 AL2-126B GUCUCGGCACCCACUUGCA GUCUCGGCACCCACUUGCA 735 AL2-127A CGGCAGUGACUGCAAGUGG CGGCAGUGACUGCAAGUGG 736 AL2-127B CCACUUGCAGUCACUGCCG CCACUUGCAGUCACUGCCG 737 AL2-128A AACAUCAGGCGGCAGUGAC AACAUCAGGCGGCAGUGAC 738 AL2-128B GUCACUGCCGCCUGAUGUU GUCACUGCCGCCUGAUGUU 739 AL2-129A AAGAGUAACAACAUCAGGC AAGAGUAACAACAUCAGGC 740 AL2-129B GCCUGAUGUUGUUACUCUU GCCUGAUGUUGUUACUCUU 741 AL2-130A UUUUGGAGUGGAAGAGUAA UUUUGGAGUGGAAGAGUAA 742 AL2-130B UUACUCUUCCACUCCAAAA UUACUCUUCCACUCCAAAA 743 AL2-131A ACGGGCAUCCUUUUGGAGU ACGGGCAUCCUUUUGGAGU 744 AL2-131B ACUCCAAAAGGAUGCCCGU ACUCCAAAAGGAUGCCCGU 745 AL2-132A GGGGCCUCGGCCACGGGCA GGGGCCUCGGCCACGGGCA 746 AL2-132B UGCCCGUGGCCGAGGCCCC UGCCCGUGGCCGAGGCCCC 747 AL2-133A ACCUGGGGGGCCUCGGCCA ACCUGGGGGGCCUCGGCCA 748 AL2-133B UGGCCGAGGCCCCCCAGGU UGGCCGAGGCCCCCCAGGU 749 AL2-134A CUGCCCGCCAGCCACCUGG CUGCCCGCCAGCCACCUGG 750 AL2-134B CCAGGUGGCUGGCGGGCAG CCAGGUGGCUGGCGGGCAG 751 AL2-135A CCUCCGUCCCCCUGCCCGC CCUCCGUCCCCCUGCCCGC 752 AL2-135B GCGGGCAGGGGGACGGAGG GCGGGCAGGGGGACGGAGG 753 AL2-136A CUCGCCAUCACCUCCGUCC CUCGCCAUCACCUCCGUCC 754 AL2-136B GGACGGAGGUGAUGGCGAG GGACGGAGGUGAUGGCGAG 755 AL2-137A UCCGCUUCCUCGCCAUCAC UCCGCUUCCUCGCCAUCAC 756 AL2-137B GUGAUGGCGAGGAAGCGGA GUGAUGGCGAGGAAGCGGA 757 AL2-138A UCCCCUCCGGCUCCGCUUC UCCCCUCCGGCUCCGCUUC 758 AL2-138B GAAGCGGAGCCGGAGGGGA GAAGCGGAGCCGGAGGGGA 759 AL2-139A CUUGAACAUCCCCUCCGGC CUUGAACAUCCCCUCCGGC 760 AL2-139B GCCGGAGGGGAUGUUCAAG GCCGGAGGGGAUGUUCAAG 761 AL2-140A UCCUCACAGGCCUUGAACA UCCUCACAGGCCUUGAACA 762 AL2-140B UGUUCAAGGCCUGUGAGGA UGUUCAAGGCCUGUGAGGA 763 AL2-141A UCUCUUGGAGUCCUCACAG UCUCUUGGAGUCCUCACAG 764 AL2-141B CUGUGAGGACUCCAAGAGA CUGUGAGGACUCCAAGAGA 765 AL2-142A CGGGCUUUUCUCUUGGAGU CGGGCUUUUCUCUUGGAGU 766 AL2-142B ACUCCAAGAGAAAAGCCCG ACUCCAAGAGAAAAGCCCG 767 AL2-143A GGCGGAGGUAGCCCCGGGC GGCGGAGGUAGCCCCGGGC 768 AL2-143B GCCCGGGGCUACCUCCGCC GCCCGGGGCUACCUCCGCC 769 AL2-144A AGGGGCACCAGGCGGAGGU AGGGGCACCAGGCGGAGGU 770 AL2-144B ACCUCCGCCUGGUGCCCCU ACCUCCGCCUGGUGCCCCU 771 AL2-145A ACAAACAGGGGCACCAGGC ACAAACAGGGGCACCAGGC 772 AL2-145B GCCUGGUGCCCCUGUUUGU GCCUGGUGCCCCUGUUUGU 773 AL2-146A AGGGCCAGCAGCACAAACA AGGGCCAGCAGCACAAACA 774 AL2-146B UGUUUGUGCUGCUGGCCCU UGUUUGUGCUGCUGGCCCU 775 AL2-147A AGCACGAGCAGGGCCAGCA AGCACGAGCAGGGCCAGCA 776 AL2-147B UGCUGGCCCUGCUCGUGCU UGCUGGCCCUGCUCGUGCU 777 AL2-148A CGCCGAAGCCAGCACGAGC CGCCGAAGCCAGCACGAGC 778 AL2-148B GCUCGUGCUGGCUUCGGCG GCUCGUGCUGGCUUCGGCG 779 AL2-149A AGAGUAGCACCCCCGCCGA AGAGUAGCACCCCCGCCGA 780 AL2-149B UCGGCGGGGGUGCUACUCU UCGGCGGGGGUGCUACUCU 781 AL2-150A CAGAGUAGCACCCCCGCCG CAGAGUAGCACCCCCGCCG 782 AL2-150B CGGCGGGGGUGCUACUCUG CGGCGGGGGUGCUACUCUG 783 AL2-151A CCAGAGUAGCACCCCCGCC CCAGAGUAGCACCCCCGCC 784 AL2-151B GGCGGGGGUGCUACUCUGG GGCGGGGGUGCUACUCUGG 785 AL2-152A ACCAGAGUAGCACCCCCGC ACCAGAGUAGCACCCCCGC 786 AL2-152B GCGGGGGUGCUACUCUGGU GCGGGGGUGCUACUCUGGU 787 AL2-153A UACCAGAGUAGCACCCCCG UACCAGAGUAGCACCCCCG 788 AL2-153B CGGGGGUGCUACUCUGGUA CGGGGGUGCUACUCUGGUA 789 AL2-154A AUACCAGAGUAGCACCCCC AUACCAGAGUAGCACCCCC 790 AL2-154B GGGGGUGCUACUCUGGUAU GGGGGUGCUACUCUGGUAU 791 AL2-155A AAAUACCAGAGUAGCACCC AAAUACCAGAGUAGCACCC 792 AL2-155B GGGUGCUACUCUGGUAUUU GGGUGCUACUCUGGUAUUU 793 AL2-156A GAAAUACCAGAGUAGCACC GAAAUACCAGAGUAGCACC 794 AL2-156B GGUGCUACUCUGGUAUUUC GGUGCUACUCUGGUAUUUC 795 AL2-157A GGAAAUACCAGAGUAGCAC GGAAAUACCAGAGUAGCAC 796 AL2-157B GUGCUACUCUGGUAUUUCC GUGCUACUCUGGUAUUUCC 797 AL2-158A UAGGAAAUACCAGAGUAGC UAGGAAAUACCAGAGUAGC 798 AL2-158B GCUACUCUGGUAUUUCCUA GCUACUCUGGUAUUUCCUA 799 AL2-159A CUAGGAAAUACCAGAGUAG CUAGGAAAUACCAGAGUAG 800 AL2-159B CUACUCUGGUAUUUCCUAG CUACUCUGGUAUUUCCUAG 801 AL2-160A CCUAGGAAAUACCAGAGUA CCUAGGAAAUACCAGAGUA 802 AL2-160B UACUCUGGUAUUUCCUAGG UACUCUGGUAUUUCCUAGG 803 AL2-161A CCCUAGGAAAUACCAGAGU CCCUAGGAAAUACCAGAGU 804 AL2-161B ACUCUGGUAUUUCCUAGGG ACUCUGGUAUUUCCUAGGG 805 AL2-162A ACCCUAGGAAAUACCAGAG ACCCUAGGAAAUACCAGAG 806 AL2-162B CUCUGGUAUUUCCUAGGGU CUCUGGUAUUUCCUAGGGU 807 AL2-163A GUACCCUAGGAAAUACCAG GUACCCUAGGAAAUACCAG 808 AL2-163B CUGGUAUUUCCUAGGGUAC CUGGUAUUUCCUAGGGUAC 809 AL2-164A CUUGUACCCUAGGAAAUAC CUUGUACCCUAGGAAAUAC 810 AL2-164B GUAUUUCCUAGGGUACAAG GUAUUUCCUAGGGUACAAG 811 AL2-165A CCUUGUACCCUAGGAAAUA CCUUGUACCCUAGGAAAUA 812 AL2-165B UAUUUCCUAGGGUACAAGG UAUUUCCUAGGGUACAAGG 813 AL2-166A GCCUUGUACCCUAGGAAAU GCCUUGUACCCUAGGAAAU 814 AL2-166B AUUUCCUAGGGUACAAGGC AUUUCCUAGGGUACAAGGC 815 AL2-167A CGCCUUGUACCCUAGGAAA CGCCUUGUACCCUAGGAAA 816 AL2-167B UUUCCUAGGGUACAAGGCG UUUCCUAGGGUACAAGGCG 817 AL2-168A CCGCCUUGUACCCUAGGAA CCGCCUUGUACCCUAGGAA 818 AL2-168B UUCCUAGGGUACAAGGCGG UUCCUAGGGUACAAGGCGG 819 AL2-169A CUCCGCCUUGUACCCUAGG CUCCGCCUUGUACCCUAGG 820 AL2-169B CCUAGGGUACAAGGCGGAG CCUAGGGUACAAGGCGGAG 821 AL2-170A CCUCCGCCUUGUACCCUAG CCUCCGCCUUGUACCCUAG 822 AL2-170B CUAGGGUACAAGGCGGAGG CUAGGGUACAAGGCGGAGG 823 AL2-171A ACCUCCGCCUUGUACCCUA ACCUCCGCCUUGUACCCUA 824 AL2-171B UAGGGUACAAGGCGGAGGU UAGGGUACAAGGCGGAGGU 825 AL2-172A CACCUCCGCCUUGUACCCU CACCUCCGCCUUGUACCCU 826 AL2-172B AGGGUACAAGGCGGAGGUG AGGGUACAAGGCGGAGGUG 827 AL2-173A UCACCUCCGCCUUGUACCC UCACCUCCGCCUUGUACCC 828 AL2-173B GGGUACAAGGCGGAGGUGA GGGUACAAGGCGGAGGUGA 829 AL2-174A AUCACCUCCGCCUUGUACC AUCACCUCCGCCUUGUACC 830 AL2-174B GGUACAAGGCGGAGGUGAU GGUACAAGGCGGAGGUGAU 831 AL2-175A CAUCACCUCCGCCUUGUAC CAUCACCUCCGCCUUGUAC 832 AL2-175B GUACAAGGCGGAGGUGAUG GUACAAGGCGGAGGUGAUG 833 AL2-176A CCAUCACCUCCGCCUUGUA CCAUCACCUCCGCCUUGUA 834 AL2-176B UACAAGGCGGAGGUGAUGG UACAAGGCGGAGGUGAUGG 835 AL2-177A ACCAUCACCUCCGCCUUGU ACCAUCACCUCCGCCUUGU 836 AL2-177B ACAAGGCGGAGGUGAUGGU ACAAGGCGGAGGUGAUGGU 837 AL2-178A GACCAUCACCUCCGCCUUG GACCAUCACCUCCGCCUUG 838 AL2-178B CAAGGCGGAGGUGAUGGUC CAAGGCGGAGGUGAUGGUC 839 AL2-179A UGACCAUCACCUCCGCCUU UGACCAUCACCUCCGCCUU 840 AL2-179B AAGGCGGAGGUGAUGGUCA AAGGCGGAGGUGAUGGUCA 841 AL2-180A CUGACCAUCACCUCCGCCU CUGACCAUCACCUCCGCCU 842 AL2-180B AGGCGGAGGUGAUGGUCAG AGGCGGAGGUGAUGGUCAG 843 AL2-181A UACACCUGGCUGACCAUCA UACACCUGGCUGACCAUCA 844 AL2-181B UGAUGGUCAGCCAGGUGUA UGAUGGUCAGCCAGGUGUA 845 AL2-182A ACUGCCUGAGUACACCUGG ACUGCCUGAGUACACCUGG 846 AL2-182B CCAGGUGUACUCAGGCAGU CCAGGUGUACUCAGGCAGU 847 AL2-183A UUGAGUACACGCAGACUGC UUGAGUACACGCAGACUGC 848 AL2-183B GCAGUCUGCGUGUACUCAA GCAGUCUGCGUGUACUCAA 849 AL2-184A GUGGCGAUUGAGUACACGC GUGGCGAUUGAGUACACGC 850 AL2-184B GCGUGUACUCAAUCGCCAC GCGUGUACUCAAUCGCCAC 851 AL2-185A AUCCUGGGAGAAGUGGCGA AUCCUGGGAGAAGUGGCGA 852 AL2-185B UCGCCACUUCUCCCAGGAU UCGCCACUUCUCCCAGGAU 853 AL2-186A GCGGGUAAGAUCCUGGGAG GCGGGUAAGAUCCUGGGAG 854 AL2-186B CUCCCAGGAUCUUACCCGC CUCCCAGGAUCUUACCCGC 855 AL2-187A ACUAGAUUCCCGGCGGGUA ACUAGAUUCCCGGCGGGUA 856 AL2-187B UACCCGCCGGGAAUCUAGU UACCCGCCGGGAAUCUAGU 857 AL2-188A GAAGGCACUAGAUUCCCGG GAAGGCACUAGAUUCCCGG 858 AL2-188B CCGGGAAUCUAGUGCCUUC CCGGGAAUCUAGUGCCUUC 859 AL2-189A UUUCACUGCGGAAGGCACU UUUCACUGCGGAAGGCACU 860 AL2-189B AGUGCCUUCCGCAGUGAAA AGUGCCUUCCGCAGUGAAA 861 AL2-190A UGGGCUUUGGCGGUUUCAC UGGGCUUUGGCGGUUUCAC 862 AL2-190B GUGAAACCGCCAAAGCCCA GUGAAACCGCCAAAGCCCA 863 AL2-191A CAUCUUCUGGGCUUUGGCG CAUCUUCUGGGCUUUGGCG 864 AL2-191B CGCCAAAGCCCAGAAGAUG CGCCAAAGCCCAGAAGAUG 865 AL2-192A GCUCCUUGAGCAUCUUCUG GCUCCUUGAGCAUCUUCUG 866 AL2-192B CAGAAGAUGCUCAAGGAGC CAGAAGAUGCUCAAGGAGC 867 AL2-193A CUGGUGAUGAGCUCCUUGA CUGGUGAUGAGCUCCUUGA 868 AL2-193B UCAAGGAGCUCAUCACCAG UCAAGGAGCUCAUCACCAG 869 AL2-194A UUCCCAGGCGGGUGCUGGU UUCCCAGGCGGGUGCUGGU 870 AL2-194B ACCAGCACCCGCCUGGGAA ACCAGCACCCGCCUGGGAA 871 AL2-195A UUGUAGUAAGUUCCCAGGC UUGUAGUAAGUUCCCAGGC 872 AL2-195B GCCUGGGAACUUACUACAA GCCUGGGAACUUACUACAA 873 AL2-196A CUGGAGUUGUAGUAAGUUC CUGGAGUUGUAGUAAGUUC 874 AL2-196B GAACUUACUACAACUCCAG GAACUUACUACAACUCCAG 875 AL2-197A AAUAGACGGAGCUGGAGUU AAUAGACGGAGCUGGAGUU 876 AL2-197B AACUCCAGCUCCGUCUAUU AACUCCAGCUCCGUCUAUU 877 AL2-198A UCCCCAAAGGAAUAGACGG UCCCCAAAGGAAUAGACGG 878 AL2-198B CCGUCUAUUCCUUUGGGGA CCGUCUAUUCCUUUGGGGA 879 AL2-199A GUGAGGGGUCCCUCCCCAA GUGAGGGGUCCCUCCCCAA 880 AL2-199B UUGGGGAGGGACCCCUCAC UUGGGGAGGGACCCCUCAC 881 AL2-200A AGAAGAAGCAGGUGAGGGG AGAAGAAGCAGGUGAGGGG 882 AL2-200B CCCCUCACCUGCUUCUUCU CCCCUCACCUGCUUCUUCU 883 AL2-201A AAUGAACCAGAAGAAGCAG AAUGAACCAGAAGAAGCAG 884 AL2-201B CUGCUUCUUCUGGUUCAUU CUGCUUCUUCUGGUUCAUU 885 AL2-202A GAUUUGGAGAAUGAACCAG GAUUUGGAGAAUGAACCAG 886 AL2-202B CUGGUUCAUUCUCCAAAUC CUGGUUCAUUCUCCAAAUC 887 AL2-203A GUGCUCGGGGAUUUGGAGA GUGCUCGGGGAUUUGGAGA 888 AL2-203B UCUCCAAAUCCCCGAGCAC UCUCCAAAUCCCCGAGCAC 889 AL2-204A AUCAGCCGGCGGUGCUCGG AUCAGCCGGCGGUGCUCGG 890 AL2-204B CCGAGCACCGCCGGCUGAU CCGAGCACCGCCGGCUGAU 891 AL2-205A UCGGGGCUCAGCAUCAGCC UCGGGGCUCAGCAUCAGCC 892 AL2-205B GGCUGAUGCUGAGCCCCGA GGCUGAUGCUGAGCCCCGA 893 AL2-206A UGCACCACCUCGGGGCUCA UGCACCACCUCGGGGCUCA 894 AL2-206B UGAGCCCCGAGGUGGUGCA UGAGCCCCGAGGUGGUGCA 895 AL2-207A ACCAGCAGUGCCUGCACCA ACCAGCAGUGCCUGCACCA 896 AL2-207B UGGUGCAGGCACUGCUGGU UGGUGCAGGCACUGCUGGU 897 AL2-208A UCCUCCACCAGCAGUGCCU UCCUCCACCAGCAGUGCCU 898 AL2-208B AGGCACUGCUGGUGGAGGA AGGCACUGCUGGUGGAGGA 899 AL2-209A UGGACAGCAGCUCCUCCAC UGGACAGCAGCUCCUCCAC 900 AL2-209B GUGGAGGAGCUGCUGUCCA GUGGAGGAGCUGCUGUCCA 901 AL2-210A GAGCUGUUGACUGUGGACA GAGCUGUUGACUGUGGACA 902 AL2-210B UGUCCACAGUCAACAGCUC UGUCCACAGUCAACAGCUC 903 AL2-211A ACGGCAGCCGAGCUGUUGA ACGGCAGCCGAGCUGUUGA 904 AL2-211B UCAACAGCUCGGCUGCCGU UCAACAGCUCGGCUGCCGU 905 AL2-212A UGUAGGGGACGGCAGCCGA UGUAGGGGACGGCAGCCGA 906 AL2-212B UCGGCUGCCGUCCCCUACA UCGGCUGCCGUCCCCUACA 907 AL2-213A UAGGCCCUCGGGGUCCACU UAGGCCCUCGGGGUCCACU 908 AL2-213B AGUGGACCCCGAGGGCCUA AGUGGACCCCGAGGGCCUA 909 AL2-214A UCCAGGAUCACUAGGCCCU UCCAGGAUCACUAGGCCCU 910 AL2-214B AGGGCCUAGUGAUCCUGGA AGGGCCUAGUGAUCCUGGA 911 AL2-215A CUGGCUUCCAGGAUCACUA CUGGCUUCCAGGAUCACUA 912 AL2-215B UAGUGAUCCUGGAAGCCAG UAGUGAUCCUGGAAGCCAG 913 AL2-216A AUGUCUUUCACACUGGCUU AUGUCUUUCACACUGGCUU 914 AL2-216B AAGCCAGUGUGAAAGACAU AAGCCAGUGUGAAAGACAU 915 AL2-217A AAUGCAGCUAUGUCUUUCA AAUGCAGCUAUGUCUUUCA 916 AL2-217B UGAAAGACAUAGCUGCAUU UGAAAGACAUAGCUGCAUU 917 AL2-218A CAGCGUGGAAUUCAAUGCA CAGCGUGGAAUUCAAUGCA 918 AL2-218B UGCAUUGAAUUCCACGCUG UGCAUUGAAUUCCACGCUG 919 AL2-219A CUGGCCCACGUAGCUGUAG CUGGCCCACGUAGCUGUAG 920 AL2-219B CUACAGCUACGUGGGCCAG CUACAGCUACGUGGGCCAG 921 AL2-220A CUGGCCCUGGCCCACGUAG CUGGCCCUGGCCCACGUAG 922 AL2-220B CUACGUGGGCCAGGGCCAG CUACGUGGGCCAGGGCCAG 923 AL2-221A AGCCGGAGGACCUGGCCCU AGCCGGAGGACCUGGCCCU 924 AL2-221B AGGGCCAGGUCCUCCGGCU AGGGCCAGGUCCUCCGGCU 925 AL2-222A GUCAGGCCCCUUCAGCCGG GUCAGGCCCCUUCAGCCGG 926 AL2-222B CCGGCUGAAGGGGCCUGAC CCGGCUGAAGGGGCCUGAC 927 AL2-223A AGGCCAGGUGGUCAGGCCC AGGCCAGGUGGUCAGGCCC 928 AL2-223B GGGCCUGACCACCUGGCCU GGGCCUGACCACCUGGCCU 929 AL2-224A GCAGCUGGAGGCCAGGUGG GCAGCUGGAGGCCAGGUGG 930 AL2-224B CCACCUGGCCUCCAGCUGC CCACCUGGCCUCCAGCUGC 931 AL2-225A AGGUGCCACAGGCAGCUGG AGGUGCCACAGGCAGCUGG 932 AL2-225B CCAGCUGCCUGUGGCACCU CCAGCUGCCUGUGGCACCU 933 AL2-226A GGCCCUGCAGGUGCCACAG GGCCCUGCAGGUGCCACAG 934 AL2-226B CUGUGGCACCUGCAGGGCC CUGUGGCACCUGCAGGGCC 935 AL2-227A GGUCCUUGGGGCCCUGCAG GGUCCUUGGGGCCCUGCAG 936 AL2-227B CUGCAGGGCCCCAAGGACC CUGCAGGGCCCCAAGGACC 937 AL2-228A UUGAGCAUGAGGUCCUUGG UUGAGCAUGAGGUCCUUGG 938 AL2-228B CCAAGGACCUCAUGCUCAA CCAAGGACCUCAUGCUCAA 939 AL2-229A UCCAGCCGGAGUUUGAGCA UCCAGCCGGAGUUUGAGCA 940 AL2-229B UGCUCAAACUCCGGCUGGA UGCUCAAACUCCGGCUGGA 941 AL2-230A CAGCGUCCACUCCAGCCGG CAGCGUCCACUCCAGCCGG 942 AL2-230B CCGGCUGGAGUGGACGCUG CCGGCUGGAGUGGACGCUG 943 AL2-231A CCGGCACUCUGCCAGCGUC CCGGCACUCUGCCAGCGUC 944 AL2-231B GACGCUGGCAGAGUGCCGG GACGCUGGCAGAGUGCCGG 945 AL2-232A UCGGUCCCGGCACUCUGCC UCGGUCCCGGCACUCUGCC 946 AL2-232B GGCAGAGUGCCGGGACCGA GGCAGAGUGCCGGGACCGA 947 AL2-233A UCAUACAUGGCCAGUCGGU UCAUACAUGGCCAGUCGGU 948 AL2-233B ACCGACUGGCCAUGUAUGA ACCGACUGGCCAUGUAUGA 949 AL2-234A CCGGCCACGUCAUACAUGG CCGGCCACGUCAUACAUGG 950 AL2-234B CCAUGUAUGACGUGGCCGG CCAUGUAUGACGUGGCCGG 951 AL2-235A UCUCCAGGGGCCCGGCCAC UCUCCAGGGGCCCGGCCAC 952 AL2-235B GUGGCCGGGCCCCUGGAGA GUGGCCGGGCCCCUGGAGA 953 AL2-236A AUGAGCCUCUUCUCCAGGG AUGAGCCUCUUCUCCAGGG 954 AL2-236B CCCUGGAGAAGAGGCUCAU CCCUGGAGAAGAGGCUCAU 955 AL2-237A GAGGUGAUGAGCCUCUUCU GAGGUGAUGAGCCUCUUCU 956 AL2-237B AGAAGAGGCUCAUCACCUC AGAAGAGGCUCAUCACCUC 957 AL2-238A UGCAGCCGUACACCGAGGU UGCAGCCGUACACCGAGGU 958 AL2-238B ACCUCGGUGUACGGCUGCA ACCUCGGUGUACGGCUGCA 959 AL2-239A UCCUGGCGGCUGCAGCCGU UCCUGGCGGCUGCAGCCGU 960 AL2-239B ACGGCUGCAGCCGCCAGGA ACGGCUGCAGCCGCCAGGA 961 AL2-240A ACCACGGGCUCCUGGCGGC ACCACGGGCUCCUGGCGGC 962 AL2-240B GCCGCCAGGAGCCCGUGGU GCCGCCAGGAGCCCGUGGU 963 AL2-241A AGAACCUCCACCACGGGCU AGAACCUCCACCACGGGCU 964 AL2-241B AGCCCGUGGUGGAGGUUCU AGCCCGUGGUGGAGGUUCU 965 AL2-242A CCGACGCCAGAACCUCCAC CCGACGCCAGAACCUCCAC 966 AL2-242B GUGGAGGUUCUGGCGUCGG GUGGAGGUUCUGGCGUCGG 967 AL2-243A AUGAUGGCCCCCGACGCCA AUGAUGGCCCCCGACGCCA 968 AL2-243B UGGCGUCGGGGGCCAUCAU UGGCGUCGGGGGCCAUCAU 969 AL2-244A CAGACGACCGCCAUGAUGG CAGACGACCGCCAUGAUGG 970 AL2-244B CCAUCAUGGCGGUCGUCUG CCAUCAUGGCGGUCGUCUG 971 AL2-245A CCUUCUUCCAGACGACCGC CCUUCUUCCAGACGACCGC 972 AL2-245B GCGGUCGUCUGGAAGAAGG GCGGUCGUCUGGAAGAAGG 973 AL2-246A CUGUGCAGGCCCUUCUUCC CUGUGCAGGCCCUUCUUCC 974 AL2-246B GGAAGAAGGGCCUGCACAG GGAAGAAGGGCCUGCACAG 975 AL2-247A GUCGUAGUAGCUGUGCAGG GUCGUAGUAGCUGUGCAGG 976 AL2-247B CCUGCACAGCUACUACGAC CCUGCACAGCUACUACGAC 977 AL2-248A AGCACGAAGGGGUCGUAGU AGCACGAAGGGGUCGUAGU 978 AL2-248B ACUACGACCCCUUCGUGCU ACUACGACCCCUUCGUGCU 979 AL2-249A UGCACGGAGAGCACGAAGG UGCACGGAGAGCACGAAGG 980 AL2-249B CCUUCGUGCUCUCCGUGCA CCUUCGUGCUCUCCGUGCA 981 AL2-250A AAGACCACCGGCUGCACGG AAGACCACCGGCUGCACGG 982 AL2-250B CCGUGCAGCCGGUGGUCUU CCGUGCAGCCGGUGGUCUU 983 AL2-251A CAGGCCUGGAAGACCACCG CAGGCCUGGAAGACCACCG 984 AL2-251B CGGUGGUCUUCCAGGCCUG CGGUGGUCUUCCAGGCCUG 985 AL2-252A AGGUUCACUUCACAGGCCU AGGUUCACUUCACAGGCCU 986 AL2-252B AGGCCUGUGAAGUGAACCU AGGCCUGUGAAGUGAACCU 987 AL2-253A UCCAGCGUCAGGUUCACUU UCCAGCGUCAGGUUCACUU 988 AL2-253B AAGUGAACCUGACGCUGGA AAGUGAACCUGACGCUGGA 989 AL2-254A GAGCCUGUUGUCCAGCGUC GAGCCUGUUGUCCAGCGUC 990 AL2-254B GACGCUGGACAACAGGCUC GACGCUGGACAACAGGCUC 991 AL2-255A UGGGAGUCGAGCCUGUUGU UGGGAGUCGAGCCUGUUGU 992 AL2-255B ACAACAGGCUCGACUCCCA ACAACAGGCUCGACUCCCA 993 AL2-256A CUGAGGACGCCCUGGGAGU CUGAGGACGCCCUGGGAGU 994 AL2-256B ACUCCCAGGGCGUCCUCAG ACUCCCAGGGCGUCCUCAG 995 AL2-257A UAGCUGGGGAAGUACGGGG UAGCUGGGGAAGUACGGGG 996 AL2-257B CCCCGUACUUCCCCAGCUA CCCCGUACUUCCCCAGCUA 997 AL2-258A GCGAGUAGUAGCUGGGGAA GCGAGUAGUAGCUGGGGAA 998 AL2-258B UUCCCCAGCUACUACUCGC UUCCCCAGCUACUACUCGC 999 AL2-259A UGGGUUUGGGGCGAGUAGU UGGGUUUGGGGCGAGUAGU 1000 AL2-259B ACUACUCGCCCCAAACCCA ACUACUCGCCCCAAACCCA 1001 AL2-260A CAGGAGCAGUGGGUUUGGG CAGGAGCAGUGGGUUUGGG 1002 AL2-260B CCCAAACCCACUGCUCCUG CCCAAACCCACUGCUCCUG 1003 AL2-261A ACCGUGAGGUGCCAGGAGC ACCGUGAGGUGCCAGGAGC 1004 AL2-261B GCUCCUGGCACCUCACGGU GCUCCUGGCACCUCACGGU 1005 AL2-262A AGAGAGGGCACCGUGAGGU AGAGAGGGCACCGUGAGGU 1006 AL2-262B ACCUCACGGUGCCCUCUCU ACCUCACGGUGCCCUCUCU 1007 AL2-263A CAAGCCGUAGUCCAGAGAG CAAGCCGUAGUCCAGAGAG 1008 AL2-263B CUCUCUGGACUACGGCUUG CUCUCUGGACUACGGCUUG 1009 AL2-264A AGAGGGCCAAGCCGUAGUC AGAGGGCCAAGCCGUAGUC 1010 AL2-264B GACUACGGCUUGGCCCUCU GACUACGGCUUGGCCCUCU 1011 AL2-265A UAGGCAUCAAACCAGAGGG UAGGCAUCAAACCAGAGGG 1012 AL2-265B CCCUCUGGUUUGAUGCCUA CCCUCUGGUUUGAUGCCUA 1013 AL2-266A CAGUGCAUAGGCAUCAAAC CAGUGCAUAGGCAUCAAAC 1014 AL2-266B GUUUGAUGCCUAUGCACUG GUUUGAUGCCUAUGCACUG 1015 AL2-267A ACUUCUGCCUCCUCAGUGC ACUUCUGCCUCCUCAGUGC 1016 AL2-267B GCACUGAGGAGGCAGAAGU GCACUGAGGAGGCAGAAGU 1017 AL2-268A AAAUCAUACUUCUGCCUCC AAAUCAUACUUCUGCCUCC 1018 AL2-268B GGAGGCAGAAGUAUGAUUU GGAGGCAGAAGUAUGAUUU 1019 AL2-269A UGGGUGCACGGCAAAUCAU UGGGUGCACGGCAAAUCAU 1020 AL2-269B AUGAUUUGCCGUGCACCCA AUGAUUUGCCGUGCACCCA 1021 AL2-270A UCCACUGGCCCUGGGUGCA UCCACUGGCCCUGGGUGCA 1022 AL2-270B UGCACCCAGGGCCAGUGGA UGCACCCAGGGCCAGUGGA 1023 AL2-271A UUCUGGAUCGUCCACUGGC UUCUGGAUCGUCCACUGGC 1024 AL2-271B GCCAGUGGACGAUCCAGAA GCCAGUGGACGAUCCAGAA 1025 AL2-272A CUCCUGUUCUGGAUCGUCC CUCCUGUUCUGGAUCGUCC 1026 AL2-272B GGACGAUCCAGAACAGGAG GGACGAUCCAGAACAGGAG 1027 AL2-273A AAGCCACACAGCCUCCUGU AAGCCACACAGCCUCCUGU 1028 AL2-273B ACAGGAGGCUGUGUGGCUU ACAGGAGGCUGUGUGGCUU 1029 AL2-274A GGAUGCGCAAGCCACACAG GGAUGCGCAAGCCACACAG 1030 AL2-274B CUGUGUGGCUUGCGCAUCC CUGUGUGGCUUGCGCAUCC 1031 AL2-275A UAGGGCUGCAGGAUGCGCA UAGGGCUGCAGGAUGCGCA 1032 AL2-275B UGCGCAUCCUGCAGCCCUA UGCGCAUCCUGCAGCCCUA 1033 AL2-276A AUCCUCUCGGCGUAGGGCU AUCCUCUCGGCGUAGGGCU 1034 AL2-276B AGCCCUACGCCGAGAGGAU AGCCCUACGCCGAGAGGAU 1035 AL2-277A ACCACGGGGAUCCUCUCGG ACCACGGGGAUCCUCUCGG 1036 AL2-277B CCGAGAGGAUCCCCGUGGU CCGAGAGGAUCCCCGUGGU 1037 AL2-278A CCGGCCGUGGCCACCACGG CCGGCCGUGGCCACCACGG 1038 AL2-278B CCGUGGUGGCCACGGCCGG CCGUGGUGGCCACGGCCGG 1039 AL2-279A AUGGUGAUCCCGGCCGUGG AUGGUGAUCCCGGCCGUGG 1040 AL2-279B CCACGGCCGGGAUCACCAU CCACGGCCGGGAUCACCAU 1041 AL2-280A GUGAAGUUGAUGGUGAUCC GUGAAGUUGAUGGUGAUCC 1042 AL2-280B GGAUCACCAUCAACUUCAC GGAUCACCAUCAACUUCAC 1043 AL2-281A AUCUGGGAGGUGAAGUUGA AUCUGGGAGGUGAAGUUGA 1044 AL2-281B UCAACUUCACCUCCCAGAU UCAACUUCACCUCCCAGAU 1045 AL2-282A CCGGUGAGGGAGAUCUGGG CCGGUGAGGGAGAUCUGGG 1046 AL2-282B CCCAGAUCUCCCUCACCGG CCCAGAUCUCCCUCACCGG 1047 AL2-283A ACACCGGGCCCGGUGAGGG ACACCGGGCCCGGUGAGGG 1048 AL2-283B CCCUCACCGGGCCCGGUGU CCCUCACCGGGCCCGGUGU 1049 AL2-284A AGUGCACCCGCACACCGGG AGUGCACCCGCACACCGGG 1050 AL2-284B CCCGGUGUGCGGGUGCACU CCCGGUGUGCGGGUGCACU 1051 AL2-285A UCCGACUGGUUGUACAAGC UCCGACUGGUUGUACAAGC 1052 AL2-285B GCUUGUACAACCAGUCGGA GCUUGUACAACCAGUCGGA 1053 AL2-286A CAGGGGUCCGACUGGUUGU CAGGGGUCCGACUGGUUGU 1054 AL2-286B ACAACCAGUCGGACCCCUG ACAACCAGUCGGACCCCUG 1055 AL2-287A AACUCUCCAGGGCAGGGGU AACUCUCCAGGGCAGGGGU 1056 AL2-287B ACCCCUGCCCUGGAGAGUU ACCCCUGCCCUGGAGAGUU 1057 AL2-288A AACAGAGGAACUCUCCAGG AACAGAGGAACUCUCCAGG 1058 AL2-288B CCUGGAGAGUUCCUCUGUU CCUGGAGAGUUCCUCUGUU 1059 AL2-289A AGUCCAUUCACAGAACAGA AGUCCAUUCACAGAACAGA 1060 AL2-289B UCUGUUCUGUGAAUGGACU UCUGUUCUGUGAAUGGACU 1061 AL2-290A AGGGACACAGAGUCCAUUC AGGGACACAGAGUCCAUUC 1062 AL2-290B GAAUGGACUCUGUGUCCCU GAAUGGACUCUGUGUCCCU 1063 AL2-291A AUCACAGGCAGGGACACAG AUCACAGGCAGGGACACAG 1064 AL2-291B CUGUGUCCCUGCCUGUGAU CUGUGUCCCUGCCUGUGAU 1065 AL2-292A UUGACCCCAUCACAGGCAG UUGACCCCAUCACAGGCAG 1066 AL2-292B CUGCCUGUGAUGGGGUCAA CUGCCUGUGAUGGGGUCAA 1067 AL2-293A GUUGGGGCAGUCCUUGACC GUUGGGGCAGUCCUUGACC 1068 AL2-293B GGUCAAGGACUGCCCCAAC GGUCAAGGACUGCCCCAAC 1069 AL2-294A CAUCCAGGCCGUUGGGGCA CAUCCAGGCCGUUGGGGCA 1070 AL2-294B UGCCCCAACGGCCUGGAUG UGCCCCAACGGCCUGGAUG 1071 AL2-295A GUUUCUCUCAUCCAGGCCG GUUUCUCUCAUCCAGGCCG 1072 AL2-295B CGGCCUGGAUGAGAGAAAC CGGCCUGGAUGAGAGAAAC 1073 AL2-296A UGCAAACGCAGUUUCUCUC UGCAAACGCAGUUUCUCUC 1074 AL2-296B GAGAGAAACUGCGUUUGCA GAGAGAAACUGCGUUUGCA 1075 AL2-297A UGGAAUGUGGCUCUGCAAA UGGAAUGUGGCUCUGCAAA 1076 AL2-297B UUUGCAGAGCCACAUUCCA UUUGCAGAGCCACAUUCCA 1077 AL2-298A CUUUGCACUGGAAUGUGGC CUUUGCACUGGAAUGUGGC 1078 AL2-298B GCCACAUUCCAGUGCAAAG GCCACAUUCCAGUGCAAAG 1079 AL2-299A UGUGCUGUCCUCUUUGCAC UGUGCUGUCCUCUUUGCAC 1080 AL2-299B GUGCAAAGAGGACAGCACA GUGCAAAGAGGACAGCACA 1081 AL2-300A AGAUGCAUGUGCUGUCCUC AGAUGCAUGUGCUGUCCUC 1082 AL2-300B GAGGACAGCACAUGCAUCU GAGGACAGCACAUGCAUCU 1083 AL2-301A ACCUUGGGCAGUGAGAUGC ACCUUGGGCAGUGAGAUGC 1084 AL2-301B GCAUCUCACUGCCCAAGGU GCAUCUCACUGCCCAAGGU 1085 AL2-302A CCCAUCACAGACCUUGGGC CCCAUCACAGACCUUGGGC 1086 AL2-302B GCCCAAGGUCUGUGAUGGG GCCCAAGGUCUGUGAUGGG 1087 AL2-303A AAUCAGGCUGCCCAUCACA AAUCAGGCUGCCCAUCACA 1088 AL2-303B UGUGAUGGGCAGCCUGAUU UGUGAUGGGCAGCCUGAUU 1089 AL2-304A GUUGAGACAAUCAGGCUGC GUUGAGACAAUCAGGCUGC 1090 AL2-304B GCAGCCUGAUUGUCUCAAC GCAGCCUGAUUGUCUCAAC 1091 AL2-305A UCGUCGCUGCCGUUGAGAC UCGUCGCUGCCGUUGAGAC 1092 AL2-305B GUCUCAACGGCAGCGACGA GUCUCAACGGCAGCGACGA 1093 AL2-306A UGGCACUGCUCUUCGUCGC UGGCACUGCUCUUCGUCGC 1094 AL2-306B GCGACGAAGAGCAGUGCCA GCGACGAAGAGCAGUGCCA 1095 AL2-307A ACCCCUUCCUGGCACUGCU ACCCCUUCCUGGCACUGCU 1096 AL2-307B AGCAGUGCCAGGAAGGGGU AGCAGUGCCAGGAAGGGGU 1097 AL2-308A UCCCACAUGGCACCCCUUC UCCCACAUGGCACCCCUUC 1098 AL2-308B GAAGGGGUGCCAUGUGGGA GAAGGGGUGCCAUGUGGGA 1099 AL2-309A AGGUGAAUGUCCCACAUGG AGGUGAAUGUCCCACAUGG 1100 AL2-309B CCAUGUGGGACAUUCACCU CCAUGUGGGACAUUCACCU 1101 AL2-310A UCACACUGGAAGGUGAAUG UCACACUGGAAGGUGAAUG 1102 AL2-310B CAUUCACCUUCCAGUGUGA CAUUCACCUUCCAGUGUGA 1103 AL2-311A AGCUCCGGUCCUCACACUG AGCUCCGGUCCUCACACUG 1104 AL2-311B CAGUGUGAGGACCGGAGCU CAGUGUGAGGACCGGAGCU 1105 AL2-312A UCUUCACGCAGCUCCGGUC UCUUCACGCAGCUCCGGUC 1106 AL2-312B GACCGGAGCUGCGUGAAGA GACCGGAGCUGCGUGAAGA 1107 AL2-313A GUUGGGCUUCUUCACGCAG GUUGGGCUUCUUCACGCAG 1108 AL2-313B CUGCGUGAAGAAGCCCAAC CUGCGUGAAGAAGCCCAAC 1109 AL2-314A UCACACUGCGGGUUGGGCU UCACACUGCGGGUUGGGCU 1110 AL2-314B AGCCCAACCCGCAGUGUGA AGCCCAACCCGCAGUGUGA 1111 AL2-315A CGGGCCGCCCAUCACACUG CGGGCCGCCCAUCACACUG 1112 AL2-315B CAGUGUGAUGGGCGGCCCG CAGUGUGAUGGGCGGCCCG 1113 AL2-316A GUCCCUGCAGUCGGGCCGC GUCCCUGCAGUCGGGCCGC 1114 AL2-316B GCGGCCCGACUGCAGGGAC GCGGCCCGACUGCAGGGAC 1115 AL2-317A AUCCGAGCCGUCCCUGCAG AUCCGAGCCGUCCCUGCAG 1116 AL2-317B CUGCAGGGACGGCUCGGAU CUGCAGGGACGGCUCGGAU 1117 AL2-318A UGCUCCUCAUCCGAGCCGU UGCUCCUCAUCCGAGCCGU 1118 AL2-318B ACGGCUCGGAUGAGGAGCA ACGGCUCGGAUGAGGAGCA 1119 AL2-319A ACAGUCACAGUGCUCCUCA ACAGUCACAGUGCUCCUCA 1120 AL2-319B UGAGGAGCACUGUGACUGU UGAGGAGCACUGUGACUGU 1121 AL2-320A CUGGAGGCCACAGUCACAG CUGGAGGCCACAGUCACAG 1122 AL2-320B CUGUGACUGUGGCCUCCAG CUGUGACUGUGGCCUCCAG 1123 AL2-321A CUGGAGGGGCCCUGGAGGC CUGGAGGGGCCCUGGAGGC 1124 AL2-321B GCCUCCAGGGCCCCUCCAG GCCUCCAGGGCCCCUCCAG 1125 AL2-322A AACAAUGCGGCUGGAGGGG AACAAUGCGGCUGGAGGGG 1126 AL2-322B CCCCUCCAGCCGCAUUGUU CCCCUCCAGCCGCAUUGUU 1127 AL2-323A AGCUCCACCAACAAUGCGG AGCUCCACCAACAAUGCGG 1128 AL2-323B CCGCAUUGUUGGUGGAGCU CCGCAUUGUUGGUGGAGCU 1129 AL2-324A UCGGAGGACACAGCUCCAC UCGGAGGACACAGCUCCAC 1130 AL2-324B GUGGAGCUGUGUCCUCCGA GUGGAGCUGUGUCCUCCGA 1131 AL2-325A UGGCCACUCACCCUCGGAG UGGCCACUCACCCUCGGAG 1132 AL2-325B CUCCGAGGGUGAGUGGCCA CUCCGAGGGUGAGUGGCCA 1133 AL2-326A CUGCCAUGGCCACUCACCC CUGCCAUGGCCACUCACCC 1134 AL2-326B GGGUGAGUGGCCAUGGCAG GGGUGAGUGGCCAUGGCAG 1135 AL2-327A CUGGAGGCUGGCCUGCCAU CUGGAGGCUGGCCUGCCAU 1136 AL2-327B AUGGCAGGCCAGCCUCCAG AUGGCAGGCCAGCCUCCAG 1137 AL2-328A UCGACCCCGAACCUGGAGG UCGACCCCGAACCUGGAGG 1138 AL2-328B CCUCCAGGUUCGGGGUCGA CCUCCAGGUUCGGGGUCGA 1139 AL2-329A GAUGUGUCGACCCCGAACC GAUGUGUCGACCCCGAACC 1140 AL2-329B GGUUCGGGGUCGACACAUC GGUUCGGGGUCGACACAUC 1141 AL2-330A AGGGCCCCCCCACAGAUGU AGGGCCCCCCCACAGAUGU 1142 AL2-330B ACAUCUGUGGGGGGGCCCU ACAUCUGUGGGGGGGCCCU 1143 AL2-331A GCGAUGAGGGCCCCCCCAC GCGAUGAGGGCCCCCCCAC 1144 AL2-331B GUGGGGGGGCCCUCAUCGC GUGGGGGGGCCCUCAUCGC 1145 AL2-332A UCACCCAGCGGUCAGCGAU UCACCCAGCGGUCAGCGAU 1146 AL2-332B AUCGCUGACCGCUGGGUGA AUCGCUGACCGCUGGGUGA 1147 AL2-333A GCUGUUAUCACCCAGCGGU GCUGUUAUCACCCAGCGGU 1148 AL2-333B ACCGCUGGGUGAUAACAGC ACCGCUGGGUGAUAACAGC 1149 AL2-334A CAGUGGGCAGCUGUUAUCA CAGUGGGCAGCUGUUAUCA 1150 AL2-334B UGAUAACAGCUGCCCACUG UGAUAACAGCUGCCCACUG 1151 AL2-335A UCCUCCUGGAAGCAGUGGG UCCUCCUGGAAGCAGUGGG 1152 AL2-335B CCCACUGCUUCCAGGAGGA CCCACUGCUUCCAGGAGGA 1153 AL2-336A GGCCAUGCUGUCCUCCUGG GGCCAUGCUGUCCUCCUGG 1154 AL2-336B CCAGGAGGACAGCAUGGCC CCAGGAGGACAGCAUGGCC 1155 AL2-337A ACCGUGGAGGCCAUGCUGU ACCGUGGAGGCCAUGCUGU 1156 AL2-337B ACAGCAUGGCCUCCACGGU ACAGCAUGGCCUCCACGGU 1157 AL2-338A ACGGUCCACAGCACCGUGG ACGGUCCACAGCACCGUGG 1158 AL2-338B CCACGGUGCUGUGGACCGU CCACGGUGCUGUGGACCGU 1159 AL2-339A UUGCCCAGGAACACGGUCC UUGCCCAGGAACACGGUCC 1160 AL2-339B GGACCGUGUUCCUGGGCAA GGACCGUGUUCCUGGGCAA 1161 AL2-340A UGCCACACCUUGCCCAGGA UGCCACACCUUGCCCAGGA 1162 AL2-340B UCCUGGGCAAGGUGUGGCA UCCUGGGCAAGGUGUGGCA 1163 AL2-341A AGCGCGAGUUCUGCCACAC AGCGCGAGUUCUGCCACAC 1164 AL2-341B GUGUGGCAGAACUCGCGCU GUGUGGCAGAACUCGCGCU 1165 AL2-342A UCCAGGCCAGCGCGAGUUC UCCAGGCCAGCGCGAGUUC 1166 AL2-342B GAACUCGCGCUGGCCUGGA GAACUCGCGCUGGCCUGGA 1167 AL2-343A AAGGACACCUCUCCAGGCC AAGGACACCUCUCCAGGCC 1168 AL2-343B GGCCUGGAGAGGUGUCCUU GGCCUGGAGAGGUGUCCUU 1169 AL2-344A CUCACCUUGAAGGACACCU CUCACCUUGAAGGACACCU 1170 AL2-344B AGGUGUCCUUCAAGGUGAG AGGUGUCCUUCAAGGUGAG 1171 AL2-345A GAGCAGGCGGCUCACCUUG GAGCAGGCGGCUCACCUUG 1172 AL2-345B CAAGGUGAGCCGCCUGCUC CAAGGUGAGCCGCCUGCUC 1173 AL2-346A UACGGGUGCAGGAGCAGGC UACGGGUGCAGGAGCAGGC 1174 AL2-346B GCCUGCUCCUGCACCCGUA GCCUGCUCCUGCACCCGUA 1175 AL2-347A CUCUUCGUGGUACGGGUGC CUCUUCGUGGUACGGGUGC 1176 AL2-347B GCACCCGUACCACGAAGAG GCACCCGUACCACGAAGAG 1177 AL2-348A AUGGCUGUCCUCUUCGUGG AUGGCUGUCCUCUUCGUGG 1178 AL2-348B CCACGAAGAGGACAGCCAU CCACGAAGAGGACAGCCAU 1179 AL2-349A UCGUAGUCAUGGCUGUCCU UCGUAGUCAUGGCUGUCCU 1180 AL2-349B AGGACAGCCAUGACUACGA AGGACAGCCAUGACUACGA 1181 AL2-350A AGCAGCGCCACGUCGUAGU AGCAGCGCCACGUCGUAGU 1182 AL2-350B ACUACGACGUGGCGCUGCU ACUACGACGUGGCGCUGCU 1183 AL2-351A UCGAGCUGCAGCAGCGCCA UCGAGCUGCAGCAGCGCCA 1184 AL2-351B UGGCGCUGCUGCAGCUCGA UGGCGCUGCUGCAGCUCGA 1185 AL2-352A ACCACCGGGUGGUCGAGCU ACCACCGGGUGGUCGAGCU 1186 AL2-352B AGCUCGACCACCCGGUGGU AGCUCGACCACCCGGUGGU 1187 AL2-353A CGGCCGAGCGCACCACCGG CGGCCGAGCGCACCACCGG 1188 AL2-353B CCGGUGGUGCGCUCGGCCG CCGGUGGUGCGCUCGGCCG 1189 AL2-354A CGCACGGCGGCCGAGCGCA CGCACGGCGGCCGAGCGCA 1190 AL2-354B UGCGCUCGGCCGCCGUGCG UGCGCUCGGCCGCCGUGCG 1191 AL2-355A AGGCAGACGGGGCGCACGG AGGCAGACGGGGCGCACGG 1192 AL2-355B CCGUGCGCCCCGUCUGCCU CCGUGCGCCCCGUCUGCCU 1193 AL2-356A CGCGCGGGCAGGCAGACGG CGCGCGGGCAGGCAGACGG 1194 AL2-356B CCGUCUGCCUGCCCGCGCG CCGUCUGCCUGCCCGCGCG 1195 AL2-357A AAGAAGUGGGAGCGCGCGG AAGAAGUGGGAGCGCGCGG 1196 AL2-357B CCGCGCGCUCCCACUUCUU CCGCGCGCUCCCACUUCUU 1197 AL2-358A CCGGGCUCGAAGAAGUGGG CCGGGCUCGAAGAAGUGGG 1198 AL2-358B CCCACUUCUUCGAGCCCGG CCCACUUCUUCGAGCCCGG 1199 AL2-359A AGCAGUGCAGGCCGGGCUC AGCAGUGCAGGCCGGGCUC 1200 AL2-359B GAGCCCGGCCUGCACUGCU GAGCCCGGCCUGCACUGCU 1201 AL2-360A UAAUCCAGCAGUGCAGGCC UAAUCCAGCAGUGCAGGCC 1202 AL2-360B GGCCUGCACUGCUGGAUUA GGCCUGCACUGCUGGAUUA 1203 AL2-361A CGCCCCAGCCCGUAAUCCA CGCCCCAGCCCGUAAUCCA 1204 AL2-361B UGGAUUACGGGCUGGGGCG UGGAUUACGGGCUGGGGCG 1205 AL2-362A UCGCGCAAGGCGCCCCAGC UCGCGCAAGGCGCCCCAGC 1206 AL2-362B GCUGGGGCGCCUUGCGCGA GCUGGGGCGCCUUGCGCGA 1207 AL2-363A AUGGGGCCGCCCUCGCGCA AUGGGGCCGCCCUCGCGCA 1208 AL2-363B UGCGCGAGGGCGGCCCCAU UGCGCGAGGGCGGCCCCAU 1209 AL2-364A UUGCUGAUGGGGCCGCCCU UUGCUGAUGGGGCCGCCCU 1210 AL2-364B AGGGCGGCCCCAUCAGCAA AGGGCGGCCCCAUCAGCAA 1211 AL2-365A UUCUGCAGAGCGUUGCUGA UUCUGCAGAGCGUUGCUGA 1212 AL2-365B UCAGCAACGCUCUGCAGAA UCAGCAACGCUCUGCAGAA 1213 AL2-366A UGCACAUCCACUUUCUGCA UGCACAUCCACUUUCUGCA 1214 AL2-366B UGCAGAAAGUGGAUGUGCA UGCAGAAAGUGGAUGUGCA 1215 AL2-367A AUCAACUGCACAUCCACUU AUCAACUGCACAUCCACUU 1216 AL2-367B AAGUGGAUGUGCAGUUGAU AAGUGGAUGUGCAGUUGAU 1217 AL2-368A GUCCUGUGGGAUCAACUGC GUCCUGUGGGAUCAACUGC 1218 AL2-368B GCAGUUGAUCCCACAGGAC GCAGUUGAUCCCACAGGAC 1219 AL2-369A UCGCUGCACAGGUCCUGUG UCGCUGCACAGGUCCUGUG 1220 AL2-369B CACAGGACCUGUGCAGCGA CACAGGACCUGUGCAGCGA 1221 AL2-370A UAGCGAUAGACCUCGCUGC UAGCGAUAGACCUCGCUGC 1222 AL2-370B GCAGCGAGGUCUAUCGCUA GCAGCGAGGUCUAUCGCUA 1223 AL2-371A UCACCUGGUAGCGAUAGAC UCACCUGGUAGCGAUAGAC 1224 AL2-371B GUCUAUCGCUACCAGGUGA GUCUAUCGCUACCAGGUGA 1225 AL2-372A CAUGCGUGGCGUCACCUGG CAUGCGUGGCGUCACCUGG 1226 AL2-372B CCAGGUGACGCCACGCAUG CCAGGUGACGCCACGCAUG 1227 AL2-373A CGGCACACAGCAUGCGUGG CGGCACACAGCAUGCGUGG 1228 AL2-373B CCACGCAUGCUGUGUGCCG CCACGCAUGCUGUGUGCCG 1229 AL2-374A UGCGGUAGCCGGCACACAG UGCGGUAGCCGGCACACAG 1230 AL2-374B CUGUGUGCCGGCUACCGCA CUGUGUGCCGGCUACCGCA 1231 AL2-375A UCCUUCUUGCCCUUGCGGU UCCUUCUUGCCCUUGCGGU 1232 AL2-375B ACCGCAAGGGCAAGAAGGA ACCGCAAGGGCAAGAAGGA 1233 AL2-376A UGACAGGCAUCCUUCUUGC UGACAGGCAUCCUUCUUGC 1234 AL2-376B GCAAGAAGGAUGCCUGUCA GCAAGAAGGAUGCCUGUCA 1235 AL2-377A CUGAGUCACCCUGACAGGC CUGAGUCACCCUGACAGGC 1236 AL2-377B GCCUGUCAGGGUGACUCAG GCCUGUCAGGGUGACUCAG 1237 AL2-378A AGCGGACCACCUGAGUCAC AGCGGACCACCUGAGUCAC 1238 AL2-378B GUGACUCAGGUGGUCCGCU GUGACUCAGGUGGUCCGCU 1239 AL2-379A UUGCACACCAGCGGACCAC UUGCACACCAGCGGACCAC 1240 AL2-379B GUGGUCCGCUGGUGUGCAA GUGGUCCGCUGGUGUGCAA 1241 AL2-380A CUGAGUGCCUUGCACACCA CUGAGUGCCUUGCACACCA 1242 AL2-380B UGGUGUGCAAGGCACUCAG UGGUGUGCAAGGCACUCAG 1243 AL2-381A ACCAGCGGCCACUGAGUGC ACCAGCGGCCACUGAGUGC 1244 AL2-381B GCACUCAGUGGCCGCUGGU GCACUCAGUGGCCGCUGGU 1245 AL2-382A CCCGCCAGGAACCAGCGGC CCCGCCAGGAACCAGCGGC 1246 AL2-382B GCCGCUGGUUCCUGGCGGG GCCGCUGGUUCCUGGCGGG 1247 AL2-383A CUGACCAGCCCCGCCAGGA CUGACCAGCCCCGCCAGGA 1248 AL2-383B UCCUGGCGGGGCUGGUCAG UCCUGGCGGGGCUGGUCAG 1249 AL2-384A CAGGCCCCAGCUGACCAGC CAGGCCCCAGCUGACCAGC 1250 AL2-384B GCUGGUCAGCUGGGGCCUG GCUGGUCAGCUGGGGCCUG 1251 AL2-385A CCGGCCACAGCCCAGGCCC CCGGCCACAGCCCAGGCCC 1252 AL2-385B GGGCCUGGGCUGUGGCCGG GGGCCUGGGCUGUGGCCGG 1253 AL2-386A AGUUAGGCCGGCCACAGCC AGUUAGGCCGGCCACAGCC 1254 AL2-386B GGCUGUGGCCGGCCUAACU GGCUGUGGCCGGCCUAACU 1255 AL2-387A UAGACGCCGAAGUAGUUAG UAGACGCCGAAGUAGUUAG 1256 AL2-387B CUAACUACUUCGGCGUCUA CUAACUACUUCGGCGUCUA 1257 AL2-388A GAUGCGGGUGUAGACGCCG GAUGCGGGUGUAGACGCCG 1258 AL2-388B CGGCGUCUACACCCGCAUC CGGCGUCUACACCCGCAUC 1259 AL2-389A ACACCUGUGAUGCGGGUGU ACACCUGUGAUGCGGGUGU 1260 AL2-389B ACACCCGCAUCACAGGUGU ACACCCGCAUCACAGGUGU 1261 AL2-390A UCCAGCUGAUCACACCUGU UCCAGCUGAUCACACCUGU 1262 AL2-390B ACAGGUGUGAUCAGCUGGA ACAGGUGUGAUCAGCUGGA 1263 AL2-391A ACUUGCUGGAUCCAGCUGA ACUUGCUGGAUCCAGCUGA 1264 AL2-391B UCAGCUGGAUCCAGCAAGU UCAGCUGGAUCCAGCAAGU 1265 AL2-392A CUCAGGUCACCACUUGCUG CUCAGGUCACCACUUGCUG 1266 AL2-392B CAGCAAGUGGUGACCUGAG CAGCAAGUGGUGACCUGAG 1267 AL2-393A GGGGCAGUUCCUCAGGUCA GGGGCAGUUCCUCAGGUCA 1268 AL2-393B UGACCUGAGGAACUGCCCC UGACCUGAGGAACUGCCCC 1269 AL2-394A UUUGCAGGGGGGCAGUUCC UUUGCAGGGGGGCAGUUCC 1270 AL2-394B GGAACUGCCCCCCUGCAAA GGAACUGCCCCCCUGCAAA 1271 AL2-395A GGUGGGCCCUGCUUUGCAG GGUGGGCCCUGCUUUGCAG 1272 AL2-395B CUGCAAAGCAGGGCCCACC CUGCAAAGCAGGGCCCACC 1273 AL2-396A UCCAGGAGGUGGGCCCUGC UCCAGGAGGUGGGCCCUGC 1274 AL2-396B GCAGGGCCCACCUCCUGGA GCAGGGCCCACCUCCUGGA 1275 AL2-397A GCUCUCUGAGUCCAGGAGG GCUCUCUGAGUCCAGGAGG 1276 AL2-397B CCUCCUGGACUCAGAGAGC CCUCCUGGACUCAGAGAGC 1277 AL2-398A UUGCCCUGGGCUCUCUGAG UUGCCCUGGGCUCUCUGAG 1278 AL2-398B CUCAGAGAGCCCAGGGCAA CUCAGAGAGCCCAGGGCAA 1279 AL2-399A UGCUUGGCAGUUGCCCUGG UGCUUGGCAGUUGCCCUGG 1280 AL2-399B CCAGGGCAACUGCCAAGCA CCAGGGCAACUGCCAAGCA 1281 AL2-400A CCCGCCAGAAUACUUGUCC CCCGCCAGAAUACUUGUCC 1282 AL2-400B GGACAAGUAUUCUGGCGGG GGACAAGUAUUCUGGCGGG 1283 AL2-401A CUCCCCCACCCCCCGCCAG CUCCCCCACCCCCCGCCAG 1284 AL2-401B CUGGCGGGGGGUGGGGGAG CUGGCGGGGGGUGGGGGAG 1285 AL2-402A CCUGCUCUCUCCCCCACCC CCUGCUCUCUCCCCCACCC 1286 AL2-402B GGGUGGGGGAGAGAGCAGG GGGUGGGGGAGAGAGCAGG 1287 AL2-403A ACCACAGGGCCUGCUCUCU ACCACAGGGCCUGCUCUCU 1288 AL2-403B AGAGAGCAGGCCCUGUGGU AGAGAGCAGGCCCUGUGGU 1289 AL2-404A ACCUCCUGCCACCACAGGG ACCUCCUGCCACCACAGGG 1290 AL2-404B CCCUGUGGUGGCAGGAGGU CCCUGUGGUGGCAGGAGGU 1291 AL2-405A GAGACAAGAUGCCACCUCC GAGACAAGAUGCCACCUCC 1292 AL2-405B GGAGGUGGCAUCUUGUCUC GGAGGUGGCAUCUUGUCUC 1293 AL2-406A UCAGGGACGAGACAAGAUG UCAGGGACGAGACAAGAUG 1294 AL2-406B CAUCUUGUCUCGUCCCUGA CAUCUUGUCUCGUCCCUGA 1295 AL2-407A ACUGGAGCAGACAUCAGGG ACUGGAGCAGACAUCAGGG 1296 AL2-407B CCCUGAUGUCUGCUCCAGU CCCUGAUGUCUGCUCCAGU 1297 AL2-408A CCUGCCAUCACUGGAGCAG CCUGCCAUCACUGGAGCAG 1298 AL2-408B CUGCUCCAGUGAUGGCAGG CUGCUCCAGUGAUGGCAGG 1299 AL2-409A UUCUCCAUCCUCCUGCCAU UUCUCCAUCCUCCUGCCAU 1300 AL2-409B AUGGCAGGAGGAUGGAGAA AUGGCAGGAGGAUGGAGAA 1301 AL2-410A UGCUGGCACUUCUCCAUCC UGCUGGCACUUCUCCAUCC 1302 AL2-410B GGAUGGAGAAGUGCCAGCA GGAUGGAGAAGUGCCAGCA 1303 AL2-411A UGACCCCCAGCUGCUGGCA UGACCCCCAGCUGCUGGCA 1304 AL2-411B UGCCAGCAGCUGGGGGUCA UGCCAGCAGCUGGGGGUCA 1305 AL2-412A GACGUCUUGACCCCCAGCU GACGUCUUGACCCCCAGCU 1306 AL2-412B AGCUGGGGGUCAAGACGUC AGCUGGGGGUCAAGACGUC 1307 AL2-413A UCCUCAGGGGACGUCUUGA UCCUCAGGGGACGUCUUGA 1308 AL2-413B UCAAGACGUCCCCUGAGGA UCAAGACGUCCCCUGAGGA 1309 AL2-414A UGGGCCUGGGUCCUCAGGG UGGGCCUGGGUCCUCAGGG 1310 AL2-414B CCCUGAGGACCCAGGCCCA CCCUGAGGACCCAGGCCCA 1311 AL2-415A AGAAGGGCUGGGUGUGGGC AGAAGGGCUGGGUGUGGGC 1312 AL2-415B GCCCACACCCAGCCCUUCU GCCCACACCCAGCCCUUCU 1313 AL2-416A AUUGGGAGGCAGAAGGGCU AUUGGGAGGCAGAAGGGCU 1314 AL2-416B AGCCCUUCUGCCUCCCAAU AGCCCUUCUGCCUCCCAAU 1315 AL2-417A AGGAGAGAGAAUUGGGAGG AGGAGAGAGAAUUGGGAGG 1316 AL2-417B CCUCCCAAUUCUCUCUCCU CCUCCCAAUUCUCUCUCCU 1317 AL2-418A AAGGGGACGGAGGAGAGAG AAGGGGACGGAGGAGAGAG 1318 AL2-418B CUCUCUCCUCCGUCCCCUU CUCUCUCCUCCGUCCCCUU 1319 AL2-419A AGUGGAGGAAGGGGACGGA AGUGGAGGAAGGGGACGGA 1320 AL2-419B UCCGUCCCCUUCCUCCACU UCCGUCCCCUUCCUCCACU 1321 AL2-420A UAGGCAGCAGUGGAGGAAG UAGGCAGCAGUGGAGGAAG 1322 AL2-420B CUUCCUCCACUGCUGCCUA CUUCCUCCACUGCUGCCUA 1323 AL2-421A ACUGCCUUGCAUUAGGCAG ACUGCCUUGCAUUAGGCAG 1324 AL2-421B CUGCCUAAUGCAAGGCAGU CUGCCUAAUGCAAGGCAGU 1325 AL2-422A UGCUGAGCCACUGCCUUGC UGCUGAGCCACUGCCUUGC 1326 AL2-422B GCAAGGCAGUGGCUCAGCA GCAAGGCAGUGGCUCAGCA 1327 AL2-423A CAUUCUUGCUGCUGAGCCA CAUUCUUGCUGCUGAGCCA 1328 AL2-423B UGGCUCAGCAGCAAGAAUG UGGCUCAGCAGCAAGAAUG 1329 AL2-424A UGUAGAACCAGCAUUCUUG UGUAGAACCAGCAUUCUUG 1330 AL2-424B CAAGAAUGCUGGUUCUACA CAAGAAUGCUGGUUCUACA 1331 AL2-425A UCCUCGGGAUGUAGAACCA UCCUCGGGAUGUAGAACCA 1332 AL2-425B UGGUUCUACAUCCCGAGGA UGGUUCUACAUCCCGAGGA 1333 AL2-426A ACCUCAGACACUCCUCGGG ACCUCAGACACUCCUCGGG 1334 AL2-426B CCCGAGGAGUGUCUGAGGU CCCGAGGAGUGUCUGAGGU 1335 AL2-427A AGUGGGGCGCACCUCAGAC AGUGGGGCGCACCUCAGAC 1336 AL2-427B GUCUGAGGUGCGCCCCACU GUCUGAGGUGCGCCCCACU 1337 AL2-428A CCUCUGUACAGAGUGGGGC CCUCUGUACAGAGUGGGGC 1338 AL2-428B GCCCCACUCUGUACAGAGG GCCCCACUCUGUACAGAGG 1339 AL2-429A CCAAACAGCCUCUGUACAG CCAAACAGCCUCUGUACAG 1340 AL2-429B CUGUACAGAGGCUGUUUGG CUGUACAGAGGCUGUUUGG 1341 AL2-430A GGCAAGGCUGCCCAAACAG GGCAAGGCUGCCCAAACAG 1342 AL2-430B CUGUUUGGGCAGCCUUGCC CUGUUUGGGCAGCCUUGCC 1343 AL2-431A UCUGCUCUCUGGAGGCAAG UCUGCUCUCUGGAGGCAAG 1344 AL2-431B CUUGCCUCCAGAGAGCAGA CUUGCCUCCAGAGAGCAGA 1345 AL2-432A CUGGAAUCUGCUCUCUGGA CUGGAAUCUGCUCUCUGGA 1346 AL2-432B UCCAGAGAGCAGAUUCCAG UCCAGAGAGCAGAUUCCAG 1347 AL2-433A GGCUUCCGAAGCUGGAAUC GGCUUCCGAAGCUGGAAUC 1348 AL2-433B GAUUCCAGCUUCGGAAGCC GAUUCCAGCUUCGGAAGCC 1349 AL2-434A AUGGGAGCACCUUCCAUUC AUGGGAGCACCUUCCAUUC 1350 AL2-434B GAAUGGAAGGUGCUCCCAU GAAUGGAAGGUGCUCCCAU 1351 AL2-435A UCCCCUCCGAUGGGAGCAC UCCCCUCCGAUGGGAGCAC 1352 AL2-435B GUGCUCCCAUCGGAGGGGA GUGCUCCCAUCGGAGGGGA 1353 AL2-436A CUCUGAGGGUCCCCUCCGA CUCUGAGGGUCCCCUCCGA 1354 AL2-436B UCGGAGGGGACCCUCAGAG UCGGAGGGGACCCUCAGAG 1355 AL2-437A GUCUCCAGGGCUCUGAGGG GUCUCCAGGGCUCUGAGGG 1356 AL2-437B CCCUCAGAGCCCUGGAGAC CCCUCAGAGCCCUGGAGAC 1357 AL2-438A AGGCCCACCUGGCAGUCUC AGGCCCACCUGGCAGUCUC 1358 AL2-438B GAGACUGCCAGGUGGGCCU GAGACUGCCAGGUGGGCCU 1359 AL2-439A AGUGGCAGCAGGCCCACCU AGUGGCAGCAGGCCCACCU 1360 AL2-439B AGGUGGGCCUGCUGCCACU AGGUGGGCCUGCUGCCACU 1361 AL2-440A UUUUGGCUUACAGUGGCAG UUUUGGCUUACAGUGGCAG 1362 AL2-440B CUGCCACUGUAAGCCAAAA CUGCCACUGUAAGCCAAAA 1363 AL2-441A CCCACCUUUUGGCUUACAG CCCACCUUUUGGCUUACAG 1364 AL2-441B CUGUAAGCCAAAAGGUGGG CUGUAAGCCAAAAGGUGGG 1365 AL2-442A GGAGUCAGGACUUCCCCAC GGAGUCAGGACUUCCCCAC 1366 AL2-442B GUGGGGAAGUCCUGACUCC GUGGGGAAGUCCUGACUCC 1367 AL2-443A CAAGGACCCUGGAGUCAGG CAAGGACCCUGGAGUCAGG 1368 AL2-443B CCUGACUCCAGGGUCCUUG CCUGACUCCAGGGUCCUUG 1369 AL2-444A AGGGGUGGGGCAAGGACCC AGGGGUGGGGCAAGGACCC 1370 AL2-444B GGGUCCUUGCCCCACCCCU GGGUCCUUGCCCCACCCCU 1371 AL2-445A UGGCAGGCAGGGGUGGGGC UGGCAGGCAGGGGUGGGGC 1372 AL2-445B GCCCCACCCCUGCCUGCCA GCCCCACCCCUGCCUGCCA 1373 AL2-446A UGAGGGCCCAGGUGGCAGG UGAGGGCCCAGGUGGCAGG 1374 AL2-446B CCUGCCACCUGGGCCCUCA CCUGCCACCUGGGCCCUCA 1375 AL2-447A CUGGGCUGUGAGGGCCCAG CUGGGCUGUGAGGGCCCAG 1376 AL2-447B CUGGGCCCUCACAGCCCAG CUGGGCCCUCACAGCCCAG 1377 AL2-448A GUGAGGGUCUGGGCUGUGA GUGAGGGUCUGGGCUGUGA 1378 AL2-448B UCACAGCCCAGACCCUCAC UCACAGCCCAGACCCUCAC 1379 AL2-449A GAGCUCACCUCCCAGUGAG GAGCUCACCUCCCAGUGAG 1380 AL2-449B CUCACUGGGAGGUGAGCUC CUCACUGGGAGGUGAGCUC 1381 AL2-450A AAGGGCAGCUGAGCUCACC AAGGGCAGCUGAGCUCACC 1382 AL2-450B GGUGAGCUCAGCUGCCCUU GGUGAGCUCAGCUGCCCUU 1383 AL2-451A AUCAGGCAGCUUUAUUCCA AUCAGGCAGCUUUAUUCCA 1384 AL2-451B UGGAAUAAAGCUGCCUGAU UGGAAUAAAGCUGCCUGAU 1385 TMPRSS6mRNA SeeFig.3 SeeFig.3 1386 EU401Bwithout mUmCmAmCmCmUfGFCfUmUmCmUmUmCmUmGmG UCACCUGCUUCUUCUGGUU linker (ps)mU(ps)mU 1387 EU402Bwithout fUmCfAmCfCmUfGmCfUmUfCmUfUmCfUmGfG UCACCUGCUUCUUCUGGUU linker (ps)mU(ps)fU