PROTEASE VARIANTS AND USES THEREOF

Abstract

Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.

Claims

1-58. (canceled)

59. A polypeptide comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, wherein the positions correspond to the numbering as set forth in SEQ ID NO: 35.

60. The polypeptide of claim 59, wherein the polypeptide comprises a cysteine (C) at position 94; and/or has, at the positions in said variant sequence which correspond to positions 84, 262, 284 and 286 of SEQ ID NO: 35, a lysine (K), a histidine (H), an aspartic acid (D) and/or an aspartic acid (D), respectively, wherein the positions correspond to the numbering as set forth in SEQ ID NO: 35.

61. The polypeptide of claim 60, wherein the polypeptide further comprises: a positively charged amino acid at a position 130, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and/or a positively charged amino acid at a position 131, optionally wherein said positively charged amino acid is arginine (R) or lysine (K), wherein the positions correspond to the numbering as set forth in SEQ ID NO: 35.

62. The polypeptide of claim 59, wherein the polypeptide does not include the contiguous amino acid sequence of NQTN (SEQ ID NO: 1355) at the C-terminus of the polypeptide.

63. The polypeptide of claim 59, wherein the polypeptide does not include the contiguous amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351) in its entirety, or the dipeptide of VT at the N-terminus of the polypeptide.

64. The polypeptide of claim 59, wherein the polypeptide has at least 95% identity to an amino acid sequence of SEQ ID NO: 1303.

65. The polypeptide of claim 59, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 1303.

66. The polypeptide of claim 59, wherein the polypeptide is linked to a polypeptide having an amino acid sequence of SEQ ID NO: 23.

67. The polypeptide of claim 66, wherein the polypeptide is linked to the amino acid sequence of SEQ ID NO: 23 with a peptide linker.

68. The polypeptide of claim 67, wherein the peptide linker is a charged peptide linker.

69. The polypeptide of claim 67, wherein the peptide linker comprises the amino acid sequence of SEQ ID NO: 1330.

70. The polypeptide of claim 65, wherein the polypeptide is linked to a polypeptide comprising the amino acid sequence of SEQ ID NO: 23.

71. The polypeptide of claim 70, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO: 1318.

72. The polypeptide of claim 59, wherein the polypeptide is less immunogenic than a polypeptide comprising the amino acid sequence of SEQ ID NO: 35 or SEQ ID NO: 36.

73. A pharmaceutical composition comprising the polypeptide of claim 59.

74. A pharmaceutical composition comprising the polypeptide of claim 64.

75. A pharmaceutical composition comprising the polypeptide of claim 65.

76. A pharmaceutical composition comprising the polypeptide of claim 71.

77. The pharmaceutical composition of claim 76, wherein the pharmaceutical composition comprises a dimer of the polypeptide.

78. The pharmaceutical composition of claim 77, wherein the dimer comprises a first polypeptide comprising the amino acid sequence of SEQ ID NO: 1318 and a second polypeptide comprising the amino acid sequence of SEQ ID NO: 1318.

79. A method of reducing immunoglobulins in a subject, the method comprising administering to the subject the polypeptide of claim 59, or a pharmaceutical composition comprising the same.

80. The method of claim 79, wherein the polypeptide comprises the polypeptide of claim 56.

81. The method of claim 79, wherein the polypeptide comprises the polypeptide of claim 57.

82. The method of claim 79, wherein the polypeptide comprises the polypeptide of claim 63.

83. The method of claim 79, wherein the pharmaceutical composition comprises a dimer of the polypeptide.

84. The method of claim 83, wherein the dimer comprises a first polypeptide comprising the amino acid sequence of SEQ ID NO: 1318 and a second polypeptide comprising the amino acid sequence of SEQ ID NO: 1318.

Description

BRIEF DESCRIPTION OF DRAWINGS

[0005] FIG. 1 illustrates performance of IdeS-Fc polypeptide against IdeS.

[0006] FIG. 2A illustrates PK measurements.

[0007] FIG. 2B illustrates PD measurements.

[0008] FIG. 3 illustrates PK and PD measurements.

[0009] FIG. 4A illustrates urine protein scores.

[0010] FIG. 4B illustrates urine protein scores.

[0011] FIG. 4C illustrates blood urea nitrogen levels.

[0012] FIG. 4D illustrates analysis of in vivo kidney injury.

[0013] FIG. 4E illustrates analysis of in vivo kidney injury.

[0014] FIG. 4F illustrates analysis of in vivo kidney injury.

[0015] FIG. 5A illustrates analysis of B cell receptor kappa cleavage.

[0016] FIG. 5B illustrates analysis of B cell receptor lambda cleavage.

[0017] FIG. 6 shows results of a human plasma cleavage assay.

[0018] FIGS. 7A and 7B show results of a human plasma cleavage assay.

[0019] FIG. 8 shows decreased levels of pre-formed IgG binding to protease variants relative to wild-type Fc-IdeS.

[0020] FIG. 9 illustrates the alignment of non-limiting protease variant to wild-type protease sequence.

DETAILED DESCRIPTION

[0021] As used herein and in the appended claims, the singular forms a, an and the include plural reference unless the context clearly dictates otherwise.

[0022] As used herein, the term about means that the numerical value is approximate and small variations would not significantly affect the practice of the disclosed embodiments. Where a numerical limitation is used, unless indicated otherwise by the context, about means the numerical value can vary by ?5% and remain within the scope of the disclosed embodiments. Thus, about 100 means 95 to 105.

[0023] As used herein, the term animal includes, but is not limited to, humans and non-human vertebrates such as wild, domestic, and farm animals. As used herein, the term mammal means a rodent (i.e., a mouse, a rat, or a guinea pig), a monkey, a cat, a dog, a cow, a horse, a pig, or a human. In some embodiments, the mammal is a human.

[0024] As used herein, the term contacting means bringing together of two elements in an in vitro system or an in vivo system. For example, contacting a therapeutic compound with an individual or patient or cell includes the administration of the compound to an individual or patient, such as a human, as well as, for example, introducing a compound into a sample containing a cellular or purified preparation containing target.

[0025] As used herein, the terms comprising (and any form of comprising, such as comprise, comprises, and comprised), having (and any form of having, such as have and has), including (and any form of including, such as includes and include), or containing (and any form of containing, such as contains and contain), are inclusive or open-ended and do not exclude additional, unrecited elements or method steps. Any composition or method that recites the term comprising should also be understood to also describe such compositions as consisting, consisting of, or consisting essentially of the recited components or elements.

[0026] As used herein, the term fused or linked when used in reference to a protein or molecule having different domains or heterologous sequences means that the protein domains are part of the same peptide chain that are connected to one another with either peptide bonds or other covalent bonding. The domains or section can be linked or fused directly to one another or another domain or peptide sequence can be between the two domains or sequences and such sequences would still be considered to be fused or linked to one another.

[0027] As used herein, the term individual, subject, or patient, used interchangeably, means any animal, including mammals, such as mice, rats, other rodents, rabbits, dogs, cats, swine, cattle, sheep, horses, or primates, such as humans.

[0028] As used herein, the term inhibit refers to a result, symptom, or activity being reduced as compared to the activity or result in the absence of the compound that is inhibiting the result, symptom, or activity. In some embodiments, the result, symptom, or activity, is inhibited by about, or, at least, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, or 99%. An result, symptom, or activity can also be inhibited if it is completely elimination or extinguished.

[0029] As used herein, the phrase in need thereof means that the subject has been identified as having a need for the particular method or treatment. In some embodiments, the identification can be by any means of diagnosis. In any of the methods and treatments described herein, the subject can be in need thereof. In some embodiments, the subject is in an environment or will be traveling to an environment in which a particular disease, disorder, or condition is prevalent.

[0030] As used herein, the phrase integer from X to Y means any integer that includes the endpoints. For example, the phrase integer from 1 to 5 means 1, 2, 3, 4, or 5.

[0031] As used herein, the phrase ophthalmically acceptable means having no persistent detrimental effect on the treated eye or the functioning thereof, or on the general health of the subject being treated. However, it will be recognized that transient effects such as minor irritation or a stinging sensation are common with topical ophthalmic administration of drugs and the existence of such transient effects is not inconsistent with the composition, formulation, or ingredient (e.g., excipient) in question being ophthalmically acceptable as herein defined.

[0032] In some embodiments, the pharmaceutical compositions can be ophthalmically acceptable or suitable for ophthalmic administration.

[0033] In some embodiments, the term therapeutic molecule can be used interchangeably with therapeutic compound, molecule, or therapeutic, and refers to any polypeptide, or protein described herein.

[0034] As used herein, the term position, is meant to refer to a location in the sequence of a polypeptide. Positions may be numbered sequentially, or according to an established format, for example the EU numbering system based on Kabat's amino acid positions. For example, position 298 is a position in the human antibody IgG1.

[0035] Specific binding or specifically binds to or is specific for a particular antigen, target, or an epitope means binding that is measurably different from a non-specific interaction. Specific binding can be measured, for example, by determining binding of a molecule compared to binding of a control molecule, which generally is a molecule of similar structure that does not have binding activity. For example, specific binding can be determined by competition with a control molecule that is similar to the target.

[0036] Specific binding for a particular antigen, target, or an epitope can be exhibited, for example, by an antibody having a K.sub.D for an antigen or epitope of at least about 10.sup.?4M, at least about 10.sup.?5M, at least about 10.sup.?6M, at least about 10.sup.?7M, at least about 10.sup.?8M, at least about 10.sup.?9M, alternatively at least about 10.sup.?10M at least about 10.sup.?11M at least about 10.sup.?12M, or greater, where K.sub.D refers to a dissociation rate of a particular antibody-target interaction. Typically, an antibody that specifically binds an antigen or target will have a K.sub.D that is, or at least, 2-, 4-, 5-, 10-, 20-, 50-, 100-, 500-, 1000-, 5,000-, 10,000-, or more times greater for a control molecule relative to the antigen or epitope.

[0037] In some embodiments, specific binding for a particular antigen, target, or an epitope can be exhibited, for example, by an antibody having a K.sub.A or K.sub.a for a target, antigen, or epitope of at least 2-, 4-, 5-, 20-, 50-, 100-, 500-, 1000-, 5,000-, 10,000- or more times greater for the target, antigen, or epitope relative to a control, where K.sub.A or K.sub.a refers to an association rate of a particular antibody-antigen interaction.

[0038] As provided herein, the compounds and compositions provided for herein can be used in methods of treatment as provided herein. As used herein, the terms treat, treated, or treating mean both therapeutic treatment and prophylactic measures wherein the object is to slow down (lessen) an undesired physiological condition, disorder or disease, or obtain beneficial or desired clinical results. For purposes of these embodiments, beneficial or desired clinical results include, but are not limited to, alleviation of symptoms; diminishment of extent of condition, disorder or disease; stabilized (i.e., not worsening) state of condition, disorder or disease; delay in onset or slowing of condition, disorder or disease progression; amelioration of the condition, disorder or disease state or remission (whether partial or total), whether detectable or undetectable; an amelioration of at least one measurable physical parameter, not necessarily discernible by the patient; or enhancement or improvement of condition, disorder or disease. Treatment includes eliciting a clinically significant response without excessive levels of side effects. Treatment also includes prolonging survival, as applicable for a specific disease, as compared to expected survival if not receiving treatment. Thus, treatment of an autoimmune condition or treating autoimmunity means an activity that alleviates or ameliorates any of the primary phenomena or secondary symptoms associated with the autoimmune condition other condition described herein when the terms treat, treated, or treating are used in conjunction with such condition.

[0039] As used herein, terms variant, molecule, therapeutic, therapeutic compound, compound, polypeptide, or protein can be used interchangeably and relate to the variants, molecules, therapeutics, therapeutic compounds, compounds, polypeptides, and proteins disclosed herein.

Variant Fc Molecules

[0040] As used herein, isotype refers to the immunoglobulin class (e.g., IgG1, IgG2, IgG3, IgG4, IgM, IgA1, IgA2, IgD, and IgE antibody) that is encoded by the heavy chain constant domain genes. The full-length amino acid sequence of each wild type human IgG constant region (including all domains, i.e., CH1 domain, hinge, CH2 domain, and CH3 domain) is cataloged in the UniProt database available on-line, e.g., as P01857 (IgG1), P01859 (IgG2), P01860 (IgG3), and P01861 (IgG4), or different allotypes thereof (SEQ ID NOs: 1, 2, 3, and 4, respectively). As used herein, a domain of a heavy chain constant region, e.g., the hinge, is of an IgG1 isotype, IgG2 isotype, IgG3 isotype, or IgG4 isotype, if the domain comprises the amino acid sequence of the corresponding domain of the respective isotype, or a variant thereof (that has a higher homology to the corresponding domain of the respective isotype than it does to that of the other isotypes).

[0041] Allotype refers to naturally occurring variants within a specific isotype group, which variants differ in a few amino acids (see, e.g., Jefferies et al. (2009) mAbs 1:1). Molecules described herein may be of any allotype.

[0042] A wild-type protein or portion thereof is a version of the protein as it is found in nature. An amino acid sequence of a wild-type protein, e.g., a heavy chain constant region, is the amino acid sequence of the protein as it occurs in nature. Due to allotypic differences, there can be more than one amino acid sequence for a wild-type protein. For example, there are several allotypes of naturally occurring human IGg1 heavy chain constant regions (e.g., Jeffries et al. (2009) mAbs 1:1).

[0043] As used herein, the term chemical liabilities is meant to refer to factors that impact a molecule's immunogenicity. Thus, in some embodiments, chemical liabilities is meant to refer to, without limitation, post-translational modifications, aggregation, glycosylation, impurities, or formulation components.

[0044] An immunoglobulin may be from any of the commonly known isotypes, including but not limited to IgA, secretory IgA, IgG and IgM. The IgG isotype is divided in subclasses in certain species: IgG1, IgG2, IgG3 and IgG4 in humans, and IgG1, IgG2a, IgG2b and IgG3 in mice. In certain embodiments, the antibodies described herein are of the human IgG1 or IgG2 subtype. Immunoglobulins, e.g., human IgG1, exist in several allotypes, which differ from each other in at most a few amino acids.

[0045] In some embodiments, the IgG proteins (hinge region underlined) are as provided in Table 1.

TABLE-US-00001 TABLE1 Isotype Sequence IgG1 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVD KSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:1) IgG2 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS NFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQP REPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDISVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRW QQGNVFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:2) IgG3 ASTKGPSVFPLAPCSRSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYTCNVNHKPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPK SCDTPPPCPRCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFKWYVDGVEVHNAKTKPR EEQYNSTFRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQVSLT CLVKGFYPSDIAVEWESSGQPENNYNTTPPMLDSDGSFFLYSKLTVDKSRWQQGNIFSCSVMHEALHNRFTQKS LSLSPGK(SEQIDNO:3) IgG4 ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQ EDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQ PREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSR WQEGNVFSCSVMHEALHNHYTQKSLSLSLGK(SEQIDNO:4)

[0046] An Fc region (fragment crystallizable region) or Fc polypeptide or Fc refers to the C-terminal region of the heavy chain of an antibody that mediates the binding of the immunoglobulin to host tissues or factors, including binding to Fc receptors located on various cells of the immune system (e.g., effector cells) or to the first component (C1q) of the classical complement system. Thus, an Fc region of an antibody of isotype IgG comprises the heavy chain constant region of the antibody excluding the first constant region immunoglobulin domain (CH1). In IgG, IgA and IgD antibody isotypes, the Fc region comprises CH2 and CH3 constant domains in each of the antibody's two heavy chains; IgM and IgE Fc regions comprise three heavy chain constant domains (CH domains 2-4) in each polypeptide chain. For IgG, the Fc region comprises immunoglobulin domains consisting of the hinge, CH2 and CH3. For purposes herein, the Fc region is defined as starting at amino acid 216 and ending at amino acid 447, wherein the numbering is according to the EU index as in Kabat. Kabat et al. (1991) Sequences of Proteins of Immunological Interest, National Institutes of Health, Bethesda, MD, and according to FIGS. 3c-3f of U.S. Pat. App. Pub. No. 2008/0248028. In some embodiments, the Fc region comprises the hinge region. The Fc may be a native (or naturally-occurring or wild-type) Fc, including any allotypic variant, or a variant Fc (e.g., a non-naturally occurring Fc), comprising, e.g., 1, 2, 3, 4, 5, 1-5, 1-10 or 5-10 or more amino acid mutations, e.g., substitutions, additions or deletions. For example, a variant Fc may comprise an amino acid sequence that is at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% identical to a wild-type Fc. Modified or mutated Fcs may have enhanced or reduced effector function and/or half-life. Fc may refer to this region in isolation or in the context of an Fc-comprising protein polypeptide such as a binding protein comprising an Fc region, also referred to as an Fc fusion protein (e.g., an antibody or immunoadhesin). In some embodiments, modified or variant Fc molecules have enhanced binding to Fc?RIIb.

[0047] A hinge, hinge domain or hinge region or antibody hinge region refers to the domain of a heavy chain constant region that joins the CH1 domain to the CH2 domain and includes the upper, middle, and lower portions of the hinge (Roux et al. J. Immunol. 1998 161:4083). The hinge provides varying levels of flexibility between the binding and effector regions of an antibody and also provides sites for intermolecular disulfide bonding between the two heavy chain constant regions. The term hinge includes wild-type hinges (such as those set forth in Table 3), as well as variants thereof (e.g., non-naturally-occurring hinges or modified hinges). For example, the term IgG1 hinge includes wild-type IgG1 hinge, as shown below, and variants having 1, 2, 3, 4, 5, 1-3, 1-5, 3-5 and/or at most 5, 4, 3, 2, or 1 mutations, e.g., substitutions, deletions or additions. In some embodiments, the hinge regions are as provided in Table 2.

TABLE-US-00002 TABLE2 Isotype HingeSequence IgG1 EPKSCDKTHTCPPCPAPELLGGP(SEQIDNO:5) IgG2 ELKTPLGDTTHTCPRCPAPELLGGP(SEQIDNO:6) IgG3 ELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPEL LGGP(SEQIDNO:7) IgG4 ESKYGPPCPSCPAPEFLGGP(SEQIDNO:8)

[0048] The term CH1 domain refers to the heavy chain constant region linking the variable domain to the hinge in a heavy chain constant domain. As used herein, a CH1 domain includes wild type CH1 domains, as well as variants thereof (e.g., non-naturally-occurring CH1 domains or modified CH1 domains). For example, the term CH1 domain includes wild-type CH1 domains and variants thereof having 1, 2, 3, 4, 5, 1-3, 1-5, 3-5 and/or at most 5, 4, 3, 2, or 1 mutations, e.g., substitutions, deletions or additions.

[0049] The term CH2 domain refers to the heavy chain constant region linking the hinge to the CH3 domain in a heavy chain constant domain. As used herein, a CH2 domain includes wild-type CH2 domains, as well as variants thereof (e.g., non-naturally-occurring CH2 domains or modified CH2 domains). For example, the term CH2 domain includes wild-type CH2 domains and variants thereof having 1, 2, 3, 4, 5, 1-3, 1-5, 3-5 and/or at most 5, 4, 3, 2, or 1 mutations, e.g., substitutions, deletions or additions.

[0050] The term CH3 domain refers to the heavy chain constant region that is C-terminus to the CH2 domain in a heavy chain constant domain. As used herein, a CH3 domain includes wild-type CH3 domains, as well as variants thereof (e.g., non-naturally-occurring CH3 domains or modified CH3 domains). For example, the term CH3 domain includes wild-type CH3 domains and variants thereof having 1, 2, 3, 4, 5, 1-3, 1-5, 3-5 and/or at most 5, 4, 3, 2, or 1 mutations, e.g., substitutions, deletions or additions.

[0051] Provided herein are variant Fc polypeptides comprising variant Fc polypeptides, e.g., Fc polypeptides that have a mutated sequence region, relative to wild-type Fc polypeptide. Exemplary variant Fc molecules comprising variant Fc polypeptides include an IgG1 hinge, a CH1 domain, a CH2 domain and a CH3 domain, wherein at least one of these constant domains has residues that are not wild-type residues, as compared to SEQ ID NO: 1, 2, 3, or 4. A variant Fc polypeptide may have effector function similar to that of wild-type IgG, or may be engineered to have enhanced effector function relative to that of the wild-type IgG. A variant Fc polypeptide may comprise a wild-type CH1, hinge, CH2 and/or CH3 domain, or a variant thereof, e.g., a CH1, hinge, CH2 and/or CH3 domain having one or more amino acid substitutions, deletions or additions relative to the corresponding wild-type domain, and/or having an amino acid sequence that is at least 70%, at least 75&, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical, or more, to the corresponding wild-type sequence.

[0052] In some embodiments, a variant Fc polypeptide comprises one or more mutations that confers resistance to recognition by a protease. In some embodiments, a variant Fc polypeptide comprises one or more mutations that confers resistance to proteolytic cleavage. In some embodiments, a variant Fc polypeptide comprises one or more mutations that confer resistance to recognition by a protease and proteolytic cleavage.

[0053] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises an amino acid mutation at any one, or more, position between positions 234 and 329, as compared to SEQ ID NO: 1, wherein the mutation comprises an insertion, a deletion or a substitution.

[0054] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation corresponding to L234A mutation, as compared to SEQ ID NO: 1.

[0055] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation corresponding to L235A mutation, as compared to SEQ ID NO: 1.

[0056] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation corresponding to G237A mutation, as compared to SEQ ID NO: 1.

[0057] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation corresponding to Y296Q mutation, as compared to SEQ ID NO: 1.

[0058] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation corresponding to P329K mutation, as compared to SEQ ID NO: 1.

[0059] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a set of mutations corresponding to L234A, L235A, and G237A mutations, as compared to SEQ ID NO: 1.

[0060] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a set of mutations corresponding to Y296Q and P329K mutations, as compared to SEQ ID NO: 1.

[0061] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a set of mutations corresponding to L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 1.

[0062] In some embodiments, a variant Fc polypeptide comprises a mutation set of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1, wherein the variant Fc polypeptide further comprises at least, about, or exactly 1-10, 1-20, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 mutations in addition to the mutation set as compared to SEQ ID NO: 1.

TABLE-US-00003 TABLE3 ID FcSeq VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 1 KTKPREEQQNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:19) VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA 2 KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:20) VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVKVSHSDPEVKENWYVDGVEVHNA 3 KTKPREEQQNSTYRVVSVLIVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:21) VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVKVSHSDPEVKENWYVDGVEVHNA 4 KTKPREEQQNKTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:22) VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 5 KTKPREEQQNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO:23) VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 6 KTKPREEQQNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO:24) VFC- DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNA 7 KTKPREEQQNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO:25) VFC- DKTHTSPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 8 KTKPREEQQNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:42) VFC- DKTHTSPPSPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 9 KTKPREEQQNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:43) VFC- DKTHTCPPCPAPELLGDSGVFLFPPKPKDTLMISRTPEVTCVVVDVSHDEPEVKENWYVDGVEVHNA 10 KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPRPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:44) VFC- DKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSDEDGEVKENWYVDGVEVHNA 11 KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALAAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:45) VFC- DKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNA 12 KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPSSIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:46) VFC- DKTHTCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSDEDGEVQFNWYVDGVEVHNA 13 KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALASSIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:47) VFC- DKTHISPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 14 KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:48) VFC- DKTHISPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKENWYVDGVEVHNA 15 KTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPS RDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGN VFSCSVMHEALHNHYTQKSLSLSPGK(SEQIDNO:49)

[0063] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23.

[0064] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, provided that the variant Fc polypeptide comprises one or more mutations at position 234, 235, 237, 265, 269, 296, 298, 329, or any combination thereof. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, provided that the variant Fc polypeptide comprises one or more mutations at position 234, 235, 237, 265, 269, 296, 298, 329, or any combination thereof. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises one or more mutations at position 234, 235, 237, 265, 269, 296, 298, 329, or any combination thereof.

[0065] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, provided that the variant Fc polypeptide comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0066] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, provided that the variant Fc polypeptide comprises a set of mutations corresponding to L234A, L235A, G237A, Y296Q, and P329K mutations. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of mutations corresponding to L234A, L235A, G237A, Y296Q, and P329K mutations.

[0067] In some embodiments, a variant Fc polypeptide comprises a mutation set of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, wherein the variant Fc polypeptide further comprises at least, about, or exactly 1-10, 1-20, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 mutations in addition to the L234A, L235A, G237A, Y296Q, and P329K mutation set as compared to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25. In some embodiments, a variant Fc polypeptide comprises a mutation set of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 23, wherein the variant Fc polypeptide further comprises at least, about, or exactly 1-10, 1-20, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 mutations in addition to the L234A, L235A, G237A, Y296Q, and P329K mutation set as compared to SEQ ID NO: 23.

[0068] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence as provided in Table 3. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 20. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 21. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 22. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 24. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 25. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 42. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 43. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 44. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 45. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 46. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 47. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 48. In some embodiments, a variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 49.

[0069] In some embodiments, a variant Fc polypeptide comprises an amino acid sequence having a C-terminal lysine (K). In some embodiments, a variant Fc polypeptide comprises an amino acid sequence not having a C-terminal lysine (K).

[0070] In some embodiments, the variant Fc polypeptide, such as those provided herein, is conjugated to another polypeptide. In some embodiments, the another polypeptide is an antibody. In some embodiments, the variant Fc polypeptide, such as those provided herein, is conjugated to an effector binding/modulating polypeptide or a tissue targeting polypeptide. In some embodiments, the variant Fc polypeptide, such as those provided herein, is conjugated to an antibody, or antigen-binding fragment thereof. In some embodiments, the variant Fc polypeptide, such as those, is conjugated to another polypeptide via a linker or a covalent bond. In some embodiments, the linker is a protein linker, such as those provided herein.

Protease Variants

[0071] The present disclosure provides for polypeptides, molecules, compounds, therapeutics, and compositions comprising a polypeptide having protease activity, which can be covalently or non-covalently connected to a Fc polypeptide domain, such as those provided for herein. In some embodiments, the polypeptide having protease activity is IdeS, IdeSsuis, IdeZ, IdeE, IdeE2, IdeZ2, or IdeC.

[0072] Streptococcus pyogenes is a significant bacterial pathogen that secretes two enzymes showing remarkable specificity for IgG; EndoS and IdeS. EndoS (Endoglycosidase in Streptococcus pyogenes) specifically hydrolyzes the functionally important N-linked glycan of IgG, and treatment with EndoS abrogates the pathogenic activity of IgG in mouse models of autoimmune disease. (Collin M, Ols?n A. EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG. Embo J. 2001; 20:3046-3055; Nandakumar K S, Collin M, Ols?n A, Nimmerjahn F, Blom A M, et al. Endoglycosidase treatment abrogates IgG arthritogenicity: importance of IgG glycosylation in arthritis. Eur J Immunol. 2007; 37:2973-2982) IdeS (Immunoglobulin G-degrading enzyme of Streptococcus pyogenes) is a cysteine proteinase which cleaves IgG with a unique degree of specificity in the hinge region. (Wenig K, Chatwell L, von Pawel-Rammingen U, Bj?rck L, Huber R, et al. Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Proc Natl Acad Sci USA. 2004; 101:17371-17376) IdeS is extremely specific for IgG, which is hydrolyzed in the hinge region after glycine residue 236 in both heavy chains, which generates one F(ab)2 and two monomeric Fc fragments. IdeE is a homolog of the secreted IgG-specific protease IdeS/Mac of Streptococcus pyogenes. The activity of IdeE is comparable with the activity of IdeZ, the corresponding enzyme of the closely related S. equi ssp. zooepidemicus.

[0073] The full sequence of IdeS is publicly available as NCBI Reference Sequence no. WP_010922160.1 and is provided herein as SEQ ID NO: 35:

TABLE-US-00004 (SEQIDNO:35) MRKRCYSTSAAVLAAVTLFVLSVDRGVIADSFSANQEIRYSEVTPYHVT SVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQ LDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHGPTPV KEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTE GKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMK KYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN.

[0074] This sequence includes an N-terminus methionine followed by a 28 amino acid secretion signal sequence. The N-terminus methionine and the signal sequence (a total of 29 amino acids at the N terminus) are typically removed to form the mature IdeS protein, the amino acid sequence of which is publicly available as UniProt Identifier Q9F1R7_STRPY and is provided herein as SEQ ID NO: 36. Another variant of an IdeS protease that can be used as a reference sequence can be as illustrated in SEQ ID NO: 1349, which is similar to the amino acid sequence of SEQ ID NO: 36, but has an additional 4 amino acid residues at the N-terminus, which are DSFS (SEQ ID NO: 1350).

[0075] IdeZ is an IgG cysteine protease produced by Streptococcus equi ssp. zooepidemicus, a bacterium predominantly found in horses. As IdeZ is not a human pathogen, human subjects do not typically have antibodies against this protein in their plasma. However, IdeZ has a level of IgG cysteine protease activity against human IgG which is considerably lower than that of IdeS. The full sequence of IdeZ is publicly available as UniProt Identifier QOPIW1 and is provided herein as SEQ ID NO: 1331 below:

TABLE-US-00005 (SEQIDNO:1331) MKTIAYPNKPHSLSAGLLTAIAIFSLASSNITYADDYQRNAAEVYAKEV PHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKVFDGKD NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKA AIDTKDSQINSQLENYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDI STIIKQELTEGRALALSHTYANVSISHVINLWGADFNAEGNLEAIYVID SDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGKD IWQKLS.

[0076] In some embodiments, IdeZ is publicly available as NCBI Reference Sequence no WP_014622780.1 and is provided herein as SEQ ID NO: 1332 below:

TABLE-US-00006 (SEQIDNO:1332) MKTIAYPNKPHSLSAGLLTAIAIFSLASSNITYADDYQRNATEAYAKEV PHQITSVWTKGVIPLIPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKD NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKA AIDTKDSQINSQLENYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKIQSTDVNRPYQDKDKRGGIFDAVFIRGDQTILLTARHDLKNKGLNDI STIIKQELTEGRALALSHIYANVSISHVINLWGADFNAEGNLEAIYVID SDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGKD IWQKLS.

[0077] The mature sequence of IdeZ is publicly available as UniProt Identifier A0A0D0YKS5_STRSZ and is provided herein as SEQ ID NO: 38.

[0078] In some embodiments, the polypeptide having protease activity is IdeS, IdeSsuis, IdeZ, IdeE, IdeE2, IdeZ2, Ide85, or IdeC. In some embodiments, the IdeS, IdeZ, IdeE, IdeE2, IdeZ2, Ide85, or IdeC protease has an amino acid sequence such as those provided herein. The mature sequence of IdeSsuis is publicly available as UniProt Identifier C5W022 and is provided herein as SEQ ID NO: 55. The mature sequence of IdeE is publicly available as UniProt Identifier COM8U6_STRE4 and is provided herein as SEQ ID NO: 37. The mature sequence of IdeE2 is publicly available as UniProt Identifier C7B615_9STRE and is provided herein as SEQ ID NO: 39. The mature sequence of IdeZ2 is publicly available as UniProt Identifier B4U2F7_STREM and is provided herein as SEQ ID NO: 40. The mature sequence of IdeC is publicly available as UniProt Identifier A0A3P5YAY8_STRCB and is provided herein as SEQ ID NO: 41. In some embodiments, the protease is an IgG degrading protease. In some embodiments, the protease is an IgM degrading protease.

TABLE-US-00007 TABLE4 ID PolypeptidehavingproteaseactivitySeq IdeS ANQEIRYSEVTPYHVISVWTKGVTPPAQFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPY LSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDEK EKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGM KKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:26) IdeS- ANQEIRYSEVTPYHVTSVWTKNVTPPAQFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT Glycan AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGSQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY LSTKHLGVFPDHVIDMFINGYRLSLNNSGPTPVKNGSKDPRGGIFDAVFTRGDQSKLLTSRHDFK NKSLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGTLKAIYVTDSDSNASIGM KKYFVGVNNATKVAISAKEIKENNTGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:28) IdeS- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT NAQ AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY LSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFK EKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNAQIGM KKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:29) IdeS- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT NAQ- AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY G/S LSTKHLGVFPDHVIDMFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFK Linker EKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNAQIGM KKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTNGGGGS(C-terminus) (SEQIDNO:31) IdeS ANQEIRYSEVTPYHVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTENGKDDLLCGAAT variant AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY LSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFK EKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGM KKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:36) IdeS DSFSANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLC variant GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEK AFPYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSR HDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNA SIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO: 1349) IdeS- ANQEIRYSNVTPYHVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT GlycanN42 AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY LSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDEK EKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGM KKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:50) IdeS- ANQEIRYSEVTPYHNTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAAT Glycan AGNMLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY N47N274 LSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFK EKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGSLKAIYVTDSDSNASIGM KKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:51) IdeSsuis DTVVTGVNEIIEESQVKDEVSIESEKNESLDGSNIEIVEEIADNIPSPVIAEGEVAVEMKVDRGT ENVVSRNDTEVTTSEQNQIEVTETKEILNQTSYQTESGEQRQIIWAHGITPPAMEQSGGFVKEKY GDYLNYTAPFEAGKGYYDTNKSLNASFIDLNLCFAAVSSNMVHWWLEQNSSYVERYLKEKKGTVN VEENYAITDLRRYINSFQNQQNSRVFDMFKTYYGYRINGFVSDALVDLFINGYKPKAQGGVNLED SQLVPDSRGGFFYDVFKEKKLTNRIFSGSYERFGEDVRTVLESKGLLGLTYRTLGYATHIVTVWG AEYDNQGKIKAVYITDSDDQQEQIGLKRMGITRDASGNPRLNNHMKNNSAGALLDYVHTIRLGQD LWEEYFNPLAKAKETASQTLADTKKALDLSIQGQSELPESMRLIYLEKLNNLYNQGILSIQKAES SEMLSGALENGLNSLKSLDFPISEVGNALAPDLPVGDRSTVSDVDSLSSQETSSTNLEADTENAG IIADGTNQLHFPVEAQTTSSVEAEGDNVFEQEADTLPIIIENKDEFGSELSRNMQTSETDSLVVA VEEDVKNDEVAQVEELLESEKVENQSSELLSDTLIVESANDKEEDRVEAVVSEQPDSIPHQNVEI SLVEPTNVETETVVTPINDAATPHGSPTYIDNSVTESVATPLEKDSIQAGETEIAEPTSSESTNV ETETVVTPVNDVATPHGSPTYIDNSVTESVATPLEKDSIQAGETEIAEPTSSESTNVETETVVTP VNDVATPHGSPTYIDNSVTESVATPLEKDSIQAGETEIAEPTSSESTSVEAELVDNSEIHAATSS VTPCGSSAYADGSTTESVATPLEKDSIQTGNTEIAEPTSSKSTNVEAASVDNSEIHADASLTAVS SVNLDNPVIEPVAISLIGSKRDTNAEVEVSSLSKREVRKTNTDGLISVQSKVIKKELLESSLAEA GSPLLEATIAQSSNSNSTEIGMSYQNTVLLESNNTERQVSKAEIVMEHKETELVETVSSASEPVV LVENISQTSNNTIESGKNMGVQSQAGAKQILGVEQSSKVSTPTSRQIMGVGLLTLVLGSALGLLK KRRK(SEQIDNO:55) IdeE DDYQRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDN LLCGAATAGNMLHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYF RDKAFPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTT LLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVSISHVINLWGADENAEGNLEAIYVTD SDANASIGMKKYFVGINAHRHVAISAKKIEGENIGAQVLGLFTLSSGKDIWQKLS(SEQID NO:37) IdeZ DDYQRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDN LLCGAATAGNMLHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYF RDKAFPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTT LLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTD SDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGKDIWQKLS(SEQID NO:38) IdeZ- RNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCG V2 AATAGNMLHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKA FPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTA RHDLKNKGLNDISTIIKQELTEGRALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDAN ASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGKDIWQKLS(SEQIDNO: 52) IdeE2 EVVEVWPNGQNPNGKIEILSQTEHSEHLQKLRDIEDFQAQKQADHVRYTKWLDGVTVDEHEFRKI KEYDTEYYVTPLLSGKGYYDINKDFNQDSDKCAAAVAANMFHYWFDRNRDSINRFLSQSPGENGV IKLENEKTIEVSKFLETYRSDGDYLDKSPFFDLISNSFKGPVWANKLLDAYINGYGYIHKFAKNT PHSKNNNSKFNFFKKVFDGNLLTDIHQIFDYNTFSDKLSEALYTGKAIGLAYGPGDLRRSLGHII SVWGADLDDQNRVVAIYVTDSDDKKLTIGNERVGLKRYKVSSDDQGRARLITRDKDNTGGEIRSI ETLDMGTQEWADYENKTEK(SEQIDNO:39) IdeZ2 EVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKI VDGNIAYYATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGI IELPDGQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIE DPTKNTSKINFFKEVFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIIS VWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLTAYEETHNTGGQIRGL WTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:40) IdeC RNQITTYSEATPSHITSIWTKGVTPPTNFIEGTDGSHAPYIANQGWYDITKTFNGKDDLLCAAAT AGNMLHWWFDQNKNQIEGYLTEHPEKQAIIFNGEKMFDVKEAISTKDRQLDSKLFEYFKEKAFPT LSARRRGVFPDHVIDMFINGYRLSLDNYDKTPVKEGNKDLRGGIFDQVFTRGDQSKLLINRYNLR TKTINEISQLIKQELIAGKALAISHTYNNIGISHVINLWGADENSEGNLEAIYVTDSDSNASIGM KKYYVGVNSAGEVAVSSKKIDSEHLGAAALGLYTLSAGQGIWHQTN(SEQIDNO:41) Ide85 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTENGKDDLLCGAA (wt TAGNMLHWWFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFP residues GLSARRIGVMPDLVLDMFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRH 34-341) DFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNAS IGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:57)

[0079] In some embodiments, a polypeptide having protease activity comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 4. In some embodiments, the polypeptide having protease activity is IdeS. In some embodiments, the polypeptide having protease activity is IdeSsuis. In some embodiments, the polypeptide having protease activity is IdeE. In some embodiments, the polypeptide having protease activity is IdeZ. In some embodiments, the polypeptide having protease activity is IdeE2. In some embodiments, the polypeptide having protease activity is IdeZ2. In some embodiments, the polypeptide having protease activity is Ide85. In some embodiments, the polypeptide having protease activity is IdeC. In some embodiments, a polypeptide having protease activity comprises an amino acid sequence having at least 50%, 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, or 55.

[0080] In some embodiments, a polypeptide having protease activity comprises an amino acid sequence as provided in Table 4. In some embodiments, the polypeptide having protease activity is IdeS. In some embodiments, the polypeptide having protease activity is IdeSsuis. In some embodiments, the polypeptide having protease activity is IdeE. In some embodiments, the polypeptide having protease activity is IdeZ. In some embodiments, the polypeptide having protease activity is IdeE2. In some embodiments, the polypeptide having protease activity is IdeZ2. In some embodiments, the polypeptide having protease activity is Ide85. In some embodiments, the polypeptide having protease activity is IdeC. In some embodiments, a polypeptide having protease activity comprises an amino acid sequence of SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, or 55.

[0081] In some embodiments, the protease comprises an amino acid sequence that comprises a signal sequence. In some embodiments, the protease comprises an amino acid sequence that does not comprise a signal sequence. In some embodiments, the signal sequence can have the amino acid sequence of METDTLLLWVLLLWVPGSTG (SEQ ID NO: 53), or MNIQERFSLRKSAVGLVSVSLLCAIYTSTVAA (SEQ ID NO: 54).

[0082] In some embodiments the protease has a sequence selected from Table 5.

TABLE-US-00008 TABLE5 ID PolypeptidehavingproteaseactivitySeq PRT-1 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:56) PRT-2 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQIN(SEQIDNO:57) PRT-3 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:58) PRT-4 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTENGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALAL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:59) PRT-5 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:60) PRT-6 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:61) PRT-7 MANQEIRYSEETPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWEQTN(SEQIDNO:62) PRT-8 MANQEIRYSEVTPYHVISVWTKGVTPPTNFTQGEDVFHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMFDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKDDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:63) PRT-9 MANQEIRYSEETPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALAL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSSGQDIWNQTN(SEQIDNO:64) PRT-10 MANQEIRYSEVTPYTVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQLDSELFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALAL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:65) PRT-11 MANQEIRYSEETPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIEKYLKEHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKKELSEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:66) PRT-12 MANQEIRYSEVTPYHVISVWTKGVTPPADFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWEQTN(SEQIDNO:67) PRT-13 MANQEIRYSEETPYHVISVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIEAYLKEHPEKQKINFNGEQMFDVKEAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:68) PRT-14 MANQEIRYSEVTPYTVTSVWTKGVTPPADFTQGEDVFHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSELFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLSEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:69) PRT-15 MANQEIRYSEVTPYTITSVWTKGVTPPTNFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDEIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNSNGNLKAIYVTDSDSNASIGMKKYFVGVNKAGKVAISAKEIKGDNIGAQVLG LFTLSTGQDIWEQTN(SEQIDNO:70) PRT-16 MANQEIRYSEETPYHITSVWTKGVTPPTDFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVLD MFINGYRLNLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELQEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEEDNIGAQVLG LFTLSLGQDIWNQTN(SEQIDNO:71) PRT-17 MANQEIRYSEVTPYHITSVWTKGVTPPTNFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIERYLKEHPEKQKINFNGEQMFDVKEAIDTKGSQTDSKLENYFKDKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEQSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKGDNIGAQVLG LFTLSTGQDIWEKTN(SEQIDNO:72) PRT-18 MANQEIRYSEETPYHVISVWTKGVTPPTNFTQGEDVFHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIEKYLEEHPEKQKINFNGEQMFDVKEVIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLNLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTERHDFKEKTLKEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADEDSEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQVLG LFTLSTGQDIWEQTN(SEQIDNO:73) PRT-19 MANQEIRYSEESPSVVTSVWTKGVTPPANFTYGEDVFHAPYIANQGWYDITKTENGKDDLLCGAATAGNMLHW WFDQNKDEIEAYLKKHPEKQKINFNGEQMFDVKEAIDTKDDQTNSKLFNYFKDKAFPYLSTKHLGVFPDHVLD MFINGYRLNLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLKAIYVTDSDSNASIGMKKYFVGVNAAGKVAISAKEIKDDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:74) PRT-20 MANQEIRYSEATPYHITSVWTKGVTPPANFTQGEDVFHAPYVPNQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLENYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEQSKDPRGGIFDAVFTRGDQSTLLTSRHDFKEKTLKEISDLIKKELQEGKALGI SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEQTN(SEQIDNO:75) PRT-21 MANQEIRYSEVSPSTVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGI SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:76) PRT-22 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:77) PRT-23 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMFDVKEAIDTKNSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:78) PRT-24 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:79) PRT-25 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:80) PRT-26 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:81) PRT-27 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:82) PRT-28 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKDHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:83) PRT-29 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:84) PRT-30 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:85) PRT-31 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:86) PRT-32 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDIWNQTN(SEQIDNO:87) PRT-33 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLKEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:88) PRT-34 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:89) PRT-35 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKDHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:90) PRT-36 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQIN(SEQIDNO:91) PRT-37 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:92) PRT-38 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:93) PRT-39 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:94) PRT-40 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:95) PRT-41 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDYIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:96) PRT-42 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKQKINFNGEQMFDVKEAIDTKNDQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:97) PRT-43 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKQKINFNGEQMFDVKEAIDTKNDQTDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQIN(SEQIDNO:98) PRT-44 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTENGGDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQTDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLINHGPTPVKEGSKDPRGGFFDDVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:99) PRT-45 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTENGGDDLLCGAATAGNMLHW WFDQNKEQIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQTDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLEEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:100) PRT-46 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKAKINFNGEQMFDVKEAIDTKNDQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKRYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:101) PRT-47 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGGDDLLCGAATAGNMLHW WFDQNKDQIDRYLKEHPEKAKINFNGEQMEDVKEAIDTKNDQTNSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:102) PRT-48 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYKANQGWYDINKTENGGDDLLCGAATAGNMLHW WFDQNKDYIDRYLEEHPEKQKINFNGEQMFDVKEAIDTKNNQTDSKLFEYFKEKAFPYLSTKHLGVFPDRVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDDVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELKEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYRVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:103) PRT-49 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDYIDRYLEEHPEKAKINFNGEQMFDVKEAIDTKNDQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDDVFGRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:104) PRT-50 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKGKINFNGEQMFDVKEAIDTKNNQTDSKLFEYFKEKAFPYLSTKHLGVFPDRVLD MFINGYRLSLINHGPTPVKEGSKDPRGGFFDDVFGRGDQSKLLTSRHDFKEKNLEEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:105) PRT-51 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGKDDLLCGAATAGNMLHW WFDQNKDYIDRYLKKHPEKAKINFNGEQMFDVKEAIDTKNDQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDDVFTRGDQSKLLTSRHDFKEKNLEEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDENGNLKAIYVTDSDSNASIGMKRYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:106) PRT-52 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGGDDLLCGAATAGNMLHW WFDQNKEYIDRYLKEHPEKQKINFNGEQMEDVKEAIDTKNSQTDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNYNEISDLIKKELKEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQIN(SEQIDNO:107) PRT-53 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNDQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:108) PRT-54 MANQEIRYSEVTPYHVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:109) PRT-55 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKAKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFGRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:110) PRT-56 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTENGKDDLLCGAATAGNMLHW WFDQNKEYIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:111) PRT-57 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGKDDLLCGAATAGNMLHW WFDQNKDYIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFGRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:112) PRT-58 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGKDDLLCGAATAGNMLHW WFDQNKEYIDRYLKEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDDVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:113) PRT-59 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGFFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:114) PRT-60 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKAKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFGRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:115) PRT-61 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGKDDLLCGAATAGNMLHW WFDQNKEYIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASVGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:116) PRT-62 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFGRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:117) PRT-63 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIKRYLKEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVLD MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDDVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:118) PRT-64 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIDRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:119) PRT-65 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDLVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:120) PRT-66 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDYIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:121) PRT-67 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDINKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:122) PRT-68 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDDVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQIN(SEQIDNO:123) PRT-69 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNDQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:124) PRT-70 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:125) PRT-71 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIEAYLKKHPEKQKIMFGDQELLDVRKVINTKGSQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:126) PRT-72 MANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEYIEAYLKKHPEKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPYLSARRLGVMPDLVLD MFINGYYLNVTKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:127) PRT-73 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVTKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:128) PRT-74 MANQEIRYSEVTPSHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHW WFDQNKEEIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSELFNYERDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:129) PRT-75 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYRLNVTKTQTTDVNETYQTKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKDDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:130) PRT-76 MANQEIRYSEVTPYHITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDFKEKTLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:131) PRT-77 MANQEIRYSEVTPYHVISVWTKGVTPPTNFTQGEDVFHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHW WFDQNKEEIERYLKKHPEKQKIMFGDQELLDVRKVINTKDDQKNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVGKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:132) PRT-78 MANQEIRYSEETPYHVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEYIEAYLKKHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLD MFINGYYLNVTKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:133) PRT-79 MANQEIRYSEVTPKTITSVWTKGVTPPAKFTQNEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFKDKAFPNLSARRLGVMPDLVLD MFINGYRLNVGKTQTTDVNRTYQDKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADEDSEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQV LGLFTLSTGQDIWEQTN(SEQIDNO:134) PRT-80 MANQEIRYSEVTPKHITSVWTKGVTPPTQFIQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIEAYLKKHPEKQKIMFGDQELLDVRKAINTKDDQTNSELFNYERDKAFPNLSARRLGVMPDHVLD MFINGYYLNVNKTQTTDVNRTYQEKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSDASIGMKKYFVGVNSAGKVAISAKEIKGDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:135) PRT-81 MANQEIRYSEVTPSHVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFRDKAFPNLSARRLGVMPDLVLD MFINGYYLNLTKTQTTDVNRTYQTKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEITEDNIGAQV LGLFTLSTGKDQWNQTN(SEQIDNO:136) PRT-82 MANQEIRYSEVTPSTITSVWTKGVTPPAQFIQNEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSALFNYFKDKAFPNLSARRLGVMPDLVLD MFINGYYLNVGKTQTTDVNRTYQNKDRRGGIFDAVETRGDQSKLLTARHDFKEKNLNEISDLIKQELTEGKAL ALSHTYANVSINHVINLWGADFDANGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQV LGLFTLSTGQDIWNKIN(SEQIDNO:137) PRT-83 MANQEIRYSEETPYHVISVWTKGVTPPEKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIEAYLSKHPEKQKIMFGDQELLDVRKAINTKDSQTNSELFNYERDKAFPNLSARRLGVMPDLVLD MFINGYRLNVTKTQTTDVNETYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKKELTEGKAL GISHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEENIGAQV LGLFTLSTGQDIWQQTN(SEQIDNO:138) PRT-84 MANQEIRYSEETPYTVTSVWTKGVTPPTQFIQGEDVFHAPYKANQGWYDITKTFNGKDNLLCGAATAGNMLHW WFDQNKEYIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTDSKLENYFKDKAFPNLSARRLGVMPDLVLD MFINGYYLNVGKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKSLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSDASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQV LGLFTLSSGQDIWNQIN(SEQIDNO:139) PRT-85 MANQEIRYSEVTPKTITSVWTKGVTPPADFTQGEDVFHAPYKPNQGWYDINKTFNGKDNLLCGAATAGNMLHW WFDQNKEQIEAYLKKHPEKQKIMFGDQELLDVRKAINTKDDQTDSKLFNYFKDKAFPNLSARRLGVMPDHVLD MFINGYRLNVTKTQTTDVNRTYQTKDKRGGFFDAVFTRGDQSKLLTNRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIKGENIGAQV LGLYTLSTGQDIWNQTN(SEQIDNO:140) PRT-86 MANQEIRYSEEDPKHVTSVWTKGVTPPTDFTQGEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSKLFNYFREKAFPNLSARRLGVMPDLVLD MFINGYYLNVTKTQTTDVNRTYQTKDKRGGIFDAVFTRGDQTKLLTNRHDFKEKTLNEISDLIKQELQEGKAL GLSHTYANVRINHVINLWGADFDSNGNLEAIYVTDSDANASIGMKKYFVGKNSAGKVAISAKEIKDDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:141) PRT-87 MANQEIRYSEVTPYHITSVWTKGVTPPEQFTQGEDVFHAPYIANQGWYDITKTFNGKDNLLCGAATAGNMLHW WFDQNKEEIERYLKKYPEKQKIMFGDQELLDVRKVINTKDSQTNSKLFEYFRDKAFPNLSARRLGVMPDLVLD MFINGYYLSVTKTQTTDVNRTYGNKDNRGGIFDAVFTRGDQSKLLTNRHDFKEKNLKEISQLIKQELQEGKAL ALSHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQV LGLFTLSTGQDIWEQTN(SEQIDNO:142) PRT-88 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKGDQTNSELFNYERDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQIN(SEQIDNO:143) PRT-89 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:144) PRT-90 MANQEIRYSEETPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:145) PRT-91 MANQEIRYSEETPYHITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFRDKAFPNLSARRLGVMPDLVLD MFINGYYLNVGKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:146) PRT-92 MANQEIRYSEVTPYTITSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKAINTKDDQTNSELFNYFRDKAFPNLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:147) PRT-93 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKDDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:148) PRT-94 MANQEIRYSEETPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:149) PRT-95 MANQEIRYSEVTPYHITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLD MFINGYYLNVGKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:150) PRT-96 MANQEIRYSEVTPYTVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKAINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:151) PRT-97 MANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPEKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:152) PRT-98 MANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:153) PRT-99 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQTN(SEQIDNO:154) PRT-100 MANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:155) PRT-101 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:156) PRT-102 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:157) PRT-103 MANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGSQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:158) PRT-104 MANQEIRYSEVTPYHVISVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEKIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLD MFINGYYLNVTKTQTTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:159) PRT-105 MANQEIRYSEVTPYHVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIEAYLKKHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYERDKAFPGLSARRIGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:160) PRT-106 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTLIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINASGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:161) PRT-107 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQTKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:162) PRT-108 MRNATEAYAKEVPHQITSVWTKGVTPPTPEQFRYNNEDVIHAPYTAHQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTLIKQELTEG RALALSHTYANVSISHVINLWGADENAEGNLEAIYVIDSDANASIGMKKYFVGINAAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:163) PRT-109 MRNATEAYAKEVPHTITSVWTKGVTPLTPEQFRYNNEDVIHAPYVAHQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISTLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDDNASIGMKKYFVGVNAAGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:164) PRT-110 MRNATEAYAKEVPHQITSVWTKGVTPPTPEQFRYNNEDVFHAPYTAHQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKTLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNASGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:165) PRT-111 MRNATEAYAKEVPHQITSVWTKGVTPPTPEQFRYNNEDVFHAPYLAHQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTNRHDLKNKGLNDISTLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINSAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:166) PRT-112 MRNATEAYAKEVPHKITSVWTKGVTPLTPEQFRYNGEDVIHAPYLANQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYFKDKAFPNLSARQLGVMPDH VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTKLLTARHDLKNKGLNEISTLIKQELTEG KALALSHTYANVSISHVINLWGADENAEGNLEAIYVTDSDANASIGMKKYFVGVNASGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:167) PRT-113 MRNATEAYAKEVPHTITSVWTKGVTPPTPEQFTYYNEDVFHAPYLAHQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFKDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTKLLTARHDLKNKGLNDISDLIKQELTEG KALALSHTYANVSINHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINASGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:168) PRT-114 MRNATEAYNEETPHQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLANQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFREKAFPNLSARQLGVMPDL VLDMFINGYYLNVTKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTKLLTARHDLKNKTLNEISTLIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:169) PRT-115 MRNATEAYAKETPKTITSVWTKGVTPPTPEQFRYNGEDVIHAPYLAHQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIERYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVTKTQSTDVNRPYQTKDKRGGIFDAVFTRGDQTKLLTARHDLKNKTLNDISTLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNAAGKVAISAKKIKGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:170) PRT-116 MRNATEAYNKATPTTITSVWTKGVTPPTPEQFRYNNEDVFHAPYKAHQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTKLLTARHDLKDKGLNEISDLIKQELTEG KALALSHTYANVRISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNSSGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:171) PRT-117 MRNATEAYAKEVPHTITSVWTKGVTPPTPEQFTYQNEDVFHAPYLANQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKEEIERYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISDLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNTAGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWEQLS(SEQIDNO:172) PRT-118 MRNATEAYNKETPKTITSVWTKGVTPPTPEQFTKQNEDVFHAPYVANQGWYDITKTENGKDNLLCGAATAGNM LHWWFDQNKTEIENYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDH VLDMFINGYYLNVNKTQSTDVNRPYDDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNEISTLIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGKNASGKVAISAKKIEGDNIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:173) PRT-119 MRNATEAYAKETPKQITSVWTKGVTPPTPEQFRYNNEDVFHAPYVANQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEKYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVTKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTKLLTARHDLGNKSLNEISQLIKQELQEG KALALSHTYANVRISHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:174) PRT-120 MRNATEAYNEETPKQITSVWTKGVTPLTPEDFRYNNEDVFHAPYLANQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKEEIEAYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFKDKAFPNLSARQLGVMPDL VLDMFINGYYLNVNKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTKLLTERHDLKNKGLNDISTLIKQELTEG KALALSHTYANVSINHVINLWGADFDAEGNLEAIYVTDSDSNESIGMKKYFVGINAAGKVAISAKKIEDENIG AQVLGLFTLSSGKDIWQQLS(SEQIDNO:175) PRT-121 MRNATEAYNEDTPKQITSVWTKGVTPPTPEQFRKYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNM LHWWFDQNKTEIEAYLSKYPEKQKIIFNNQELFDLRAAIDTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVTKTQSTDVNRPYQTKDKRGGIFDAVFTRGDQTTLLTSRHDLKNKTLNEISDLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAAGKVAISAKKIEGENIG AQVLGLFTLSTGKDIWEKLS(SEQIDNO:176) PRT-122 MRNATEAYAKEVPKKITSVWTKGVTPLTPEQFIYQNEDVFHAPYLAHQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKEEIERYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVTKTQSTDVNRPYQTKDKRGGIFDAVETRGDQTKLLTERHDLKNKTLEEISQLIKQELTEG KALGLSHTYANVRISHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNASGKVAISAKKIEDDNIG AQVLGLFTLSSGKDIWEKLS(SEQIDNO:177) PRT-123 MRNATEAYNKESPHTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKEEIERYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEG KALALSHTYANVRINHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIG AQVLGLFTLSTGQDIWQKLS(SEQIDNO:178) PRT-124 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG KALALSHTYANVSISHVINLWGADENAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:179) PRT-125 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVFHAPYLANQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTKLLTARHDLKNKGLNDISTLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:180) PRT-126 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISDLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNAAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:181) PRT-127 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYDITKTENGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISTLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNAHGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:182) PRT-128 MRNATEAYAKEVPKQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLANQGWYDITKTFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKTLNDISTLIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:183) PRT-129 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVFHAPYLANQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTKLLTARHDLKNKGLNDISTLIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:184) PRT-130 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISDIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGINAAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:185) PRT-131 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:186) PRT-132 MRNATEAYAKEVPKQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKTLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADENAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:187) PRT-133 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:188) PRT-134 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTLIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:189) PRT-135 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG KALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:190) PRT-136 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:191) PRT-137 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVIDSDANASIGMKKYFVGINAHGKVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:192) PRT-138 MRNATEAYAKEVPHQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADENAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:193) PRT-139 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:194) PRT-140 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFNGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:195) PRT-141 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAAGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:196) PRT-142 MRNATEAYAKEVPHQITSVWTKGVTPLTPEQFRYNNEDVFHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNM LHWWFDQNKTEIEAYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDL VLDMFINGYYLNVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEG RALALSHTYANVSISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIG AQVLGLFTLSSGKDIWQKLS(SEQIDNO:197) PRT-143 MANQEIRYSEVTPYHITSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:198) PRT-144 MANQEIRYSEVTPYHITSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNDISQLIKQELQSGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGKNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:199) PRT-145 MANQEIRYSEVTPYHITSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNTISQLIKQELQSGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGKNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:200) PRT-146 MANQEIRYSEVTPYHIKTVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNDISQLIKQELQSGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGKNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:201) PRT-147 MANQEIRYSEVTPYHIKIVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNDISQLIKQELQSGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGKNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:202) PRT-148 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNKIN(SEQIDNO:203) PRT-149 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRQTKDPRGGIFDAVFGRGDQTKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQKSWNKTN(SEQIDNO:204) PRT-150 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQEKDPRGGIFDAVEGRGDQTKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQKSWNKIN(SEQIDNO:205) PRT-151 MANQEIRYSEVTPYHVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPDKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRQTKDPRGGIFDAVFGRGDSTKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQKSWNKIN(SEQIDNO:206) PRT-152 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGKDSWEKTN(SEQIDNO:207) PRT-153 MANQEIRYSEVTPYHVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGKDSWKKIN(SEQIDNO:208) PRT-154 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIEAYLKKHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGKKSWEKTN(SEQIDNO:209) PRT-155 MANQEIRYSEVTPYHVISVWTDGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNSTQIEAYLKKHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGKKSWEKIN(SEQIDNO:210) PRT-156 MANQEIRYSEVTPYHVISVWTKGVTPPTDFTQGEDVFHAPYKANQGWYDITKTENGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINENGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:211) PRT-157 MANQEIRYSEVTPYHVTSVWTKGVTPPEDFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:212) PRT-158 MANQEIRYSEVTPYHVISVWTKGVTPPTDFIKGEDVFHAPYKAHQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELQEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:213) PRT-159 MANQEIRYSEVTPYHVISVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELQEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:214) PRT-160 MANQEIRYSEVTPYHVITVWTDGVKPPTDFIKGEDVFHAPYKAHQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELQEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:215) PRT-161 MANQEIRYSEVTPYHVTIVWTDGVKPPTDFIKGEDVFHAPYKAHQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELQEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:216) PRT-162 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:217) PRT-163 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:218) PRT-164 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNSQENSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:219) PRT-165 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTENGGDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:220) PRT-166 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKAFDGGDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:221) PRT-167 MANQEIRYSEVTPYHVISVWTKGVTPPTDFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:222) PRT-168 MANQEIRYSEVTPYHVISVWTKGVTPPEDFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:223) PRT-169 MANQEIRYSEVTPYHVISVWTKGVTPPTDFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNDQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:224) PRT-170 MANQEIRYSEVTPYHVISVWTKGVTPPTDFIKGEDVFHAPYKAHQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:225) PRT-171 MANQEIRYSEVTPYHVISVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:226) PRT-172 MANQEIRYSEVTPYHVISVWTKGVKPPTDFIKGEDVFHAPYKAHQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQIN(SEQIDNO:227) PRT-173 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGKNASGKVAISAKEIEGENIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:228) PRT-174 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGKNASGKVAISAKEIEDENIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:229) PRT-175 MANQEIRYSEVTPYHITSVWTKGVTPPTDFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKNSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGKDSWEKIN(SEQIDNO:230) PRT-176 MANQEIRYSEVTPYHITSVWTKGVTPPTDFIKGEDVFHAPYKAHQGWYDITKTENGGDDLLCGAATAGNMLHW WFDQNKTQIEAYLKKHPEKQKINFNGEQMFDVKEAIDTKNSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVFGRGDQTKLLTSRHDFKEKTLNDISQLIKQELQSGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGKNASGKVAISAKEIEDENIGAQVLG LFTLSTGKKSWEKIN(SEQIDNO:231) PRT-177 MANQEIRYSEVTPYHIKTVWTDGVKPPTDFIKGEDVFHAPYKAHQGWYDITKAFDGGDDLLCGAATAGNMLHW WFDQNSTQIEAYLKKHPDKQKINFNGEQMEDVKEAIDTKNSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVFGRGDSTKLLTSRHDFKEKTLNDISQLIKQELQSGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGKNASGKVAISAKEIEDENIGAQVLG LFTLSTGKKSWEKTN(SEQIDNO:232) PRT-178 MANQEIRYSEVTPYHVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKIIFNNQELFDLKAAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:233) PRT-179 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSARQLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:234) PRT-180 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNTQSTDVNEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:235) PRT-181 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:236) PRT-182 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKKIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:237) PRT-183 MRNATEAYAKEVPHQVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWNQTN(SEQIDNO:238) PRT-184 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLG LFTLSTGQDSWQKLS(SEQIDNO:239) PRT-185 MANQEIRYSEVTPYHVISVWTKGVTPPANFrQGEDVFaAPYVANQGWYDITKTENGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEIntyesdhgyrdkskLFEYFKEKAFPYLSTKHLGVFPDH VIDMFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKA LGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDdkkltigderIGMKKYFVGVNSAGKVAISAKEIKE DNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:240) PRT-186 MANQEIRYSEVTPYHVISVWTKGVTPPANFrkivdgniayyHAPYVANQGWYDITKTFNGKDDLLCGAATAGN MLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPD HVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGK ALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGA QVLGLFTLSTGQDSWNQTN(SEQIDNO:241) PRT-187 MANQEIRYSEVTPYHVISVWTKGVTPPADFTYGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIEKYLKKHPEKQKIMFGDQELLDVRKVINTKGSQTNSELFNYFRDKAFPGLSARRLGVMPDLVLD MFINGYYLNVYKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKQELTEGKAL GLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDIWNQIN(SEQIDNO:242) PRT-188 MANQEIRYSEVTPYHVISVWTKGVTPPANFrkivdgniayyaAPYVANQGWYDITKTFNGKDDLLCGAATAGN MLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKElntyesdhgyrdkskLFEYFKEKAFPYLSTKHLGV FPDHVIDMFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELT EGKALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDdkkltigderIGMKKYFVGVNSAGKVAISAK EIKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:243) PRT-189 MANQEIRYSEVTPYHVTSVWTKGVTPPDHDFANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGN MLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPD HVIDMFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGK ALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGA QVLGLFTLSTGQDSWNQTN(SEQIDNO:244) PRT-190 MANQEIRYSEVTPYHVTSVWTKGVTPPDHDFRKIVDGEDVFHAPYVANQGWYDITKTENGKDDLLCGAATAGN MLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPD HVIDMFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGK ALGLSHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGA QVLGLFTLSTGQDSWNQTN(SEQIDNO:245) PRT-191 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRHSINHVINLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQV LGLFTLSTGQDSWNQTN(SEQIDNO:246) PRT-192 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDDKKLTISNASIGMKKYFVGVNSAGKVAISAKEIKEDNI GAQVLGLFTLSTGQDSWNQTN(SEQIDNO:247) PRT-193 MANQEIRYSEVTPYHVISVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFDSNGNLKAIYVTDSDDKKLTIGDERIGMKKYFVGVNSAGKVAISAKEIKEDNI GAQVLGLFTLSTGQDSWNQTN(SEQIDNO:248) PRT-194 MANQEIRYSEVTPYHVTSVWTKGVTPPDHDFANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGN MLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPD HVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGK ALGLSHTYANVRHSINHVINLWGADFDSNGNLKAIYVTDSDDKKLTISNASIGMKKYFVGVNSAGKVAISAKE IKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:249) PRT-195 MANQEIRYSEVTPYHVISVWTKGVTPPDHDFRKIVDGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGN MLHWWFDQNKDQIKRYLEEHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPYLSTKHLGVFPD HVIDMFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGK ALGLSHTYANVRHSINHVINLWGADFDSNGNLKAIYVTDSDDKKLTIGDERIGMKKYFVGVNSAGKVAISAKE IKEDNIGAQVLGLFTLSTGQDSWNQTN(SEQIDNO:250) PRT-196 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:251) PRT-197 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNENGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRARLTAYEETDNTGGQIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:252) PRT-198 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQGVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILIN NHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:253) PRT-199 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRLRLTAYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:254) PRT-200 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILIN NHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRARLTAYEETDNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:255) PRT-201 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIKDGNIEY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYEETHNTGGQIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:256) PRT-202 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDYGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKKVFNEKILTN IHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRLRLTAYEETDNTGGEIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:257) PRT-203 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIKDGNIEY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:258) PRT-204 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVTVKDHDFRKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLSQNPEKHGIIELPDGQLKLSDFLN TYESDNGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTN IHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYEETDNTGGQIRGLETLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:259) PRT-205 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKEGVVYTKWLDGVDVDDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLKQNPEKHGIIELPDGQLKLSDFLN TYESDNGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILIN NHSIRNYNTFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSSDDENRLRLTAYEETHNTGGQIRGIYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:260) PRT-206 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKENVVYTKWLDGVTVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKEVENEKILTD NHSIRDQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISYDDEGRARLTAYEEKDNTGGQIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:261) PRT-207 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKEGVVYTKWLDGVDVDDHDFRKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDRNRDNVDRFLKQNPEKHGIIELPDGQLKLSDFLN TYESDNGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILIN NHSIRNYNTFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSSDDENRLRLTAYEETHNTGGQIRGIWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:262) PRT-208 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKENVVYTKWLDGVTVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNENGPVWTDKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKEVENEKILTD NHSIRDQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISYDDEGRARLTAYEEKDNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:263) PRT-209 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQGVVYTKWLDGVDVDDHDERKIVDGNIAY YATPLLNGKGFYDINKDENRDSDKCAAAVAANMFHYWLDQNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDNGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKDVFNEKILIN IHSIRNYNTFSNLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYEENDNTGGEIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:264) PRT-210 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVTVDDHDFRKITDGNTAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDQNRDNVDRFLKQNPEKHGIIELPDGQLKLSDELN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKLLTN NHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADFDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISSDDEGRARLTAYTEKHNTGGQIRGLYTLDTGKQEWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:265) PRT-211 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQGVVYTKWLDGVDVDDHDERKIVDGNIAY YATPLLNGKGFYDINKDENRDSDKCAAAVAANMFHYWLDQNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDNGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKDVENEKILIN IHSIRNYNTFSNLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYEENDNTGGEIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:266) PRT-212 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKEGVVYTKWLDGVDVKDHDFRKIVDGNIEY YATPLLNGRGFYDINKDFNQDSDKCAAAVAANMFHYWLDRNRDNVDRFLSQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDLISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN IHSIRNQNEFSDKLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSTDDEGRLRLTAYEETDNTGGEIRGIWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:267) PRT-213 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKEGVVYTKWLDGVTVKDHDERKIVDGNIEY YATPLLNGRGWYDINKDENRDSDKCAAAVAANMFHYWLDRNRDNVDRELKQNPEKHGIIELPDGQLKLSDELN TYESDNGYRDKSKLFDFISKNFNGPVWTDKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKKVFNEKILTD IHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADEDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSTDDEGRARLTAYTETDNTGGQVRGLYTLDTGTQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:268) PRT-214 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKEGVVYTKWLDGVDVDDHDFRKITDGDIEY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDRNRDNVDRFLKQNPEKHGIIELPDGQLKLSDFLN TYESDYGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVEDEKLLTN NHSIRNYNEFSELLREALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSSDDENRARLTAYEEKDNTGGEIRGLYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:269) PRT-215 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKEGVVYTKWLDGVTVKDHDERKIVDGNIEY YATPLLNGRGWYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLKQNPEKHGIIELPDGQLKLSDFLN TYESDNGYRDKSKLFDFISKNFNGPVWTDKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKKVFNEKILTD IHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADFDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSTDDEGRARLTAYTETDNTGGQVRGLWTLDTGTQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:270) PRT-216 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKENVVYTKWLDGVDVDDHDFRKIVDGNTEY YATPLLNGRGWYDINKDFNRDSDKCAAAVAANMFHYWLDQNRDNIDRFLRQSPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYGYNYKYGRTIEDPTKNNSKINFFKKVENGKILTD NHSIRNYNTFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISYDDENRARLTAYEENDNTGGQIRGLETLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:271) PRT-217 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVTVDDSDERKIKDGNTEY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDRNRDNVDRFLKQNPEKHGIIELPDGQLKLSDFLN TYESDNNYRDKSKLFDFISKNFNGPVWTNKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKKVFNEKILTN VHQIFNYNEFSTLLSEALYTGKAIGLSYGPGGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYTETDNTGGQVRGIYTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:272) PRT-218 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQGVVYTKWLDGVNVDDHEFRKITDGNTEY YATPLLNGRGYYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPDKHGIIELPDGQLKLSDFLN TYESDHDYRDKSKLFDFISNNFNGPVWINKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKEVENGKLLTD NHSIRNKNEFSSKLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSYDDEGRARLTAYEETDNTGGEIRGLYTLDTGKQYWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:273) PRT-219 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVTVDDSDERKIKDGNTEY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLKQNPEKHGIIELPDGQLKLSDFLN TYESDNNYRDKSKLFDFISKNFNGPVWINKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKKVENEKILTN VHQIFNYNEFSTLLSEALYTGKAIGLSYGPGGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYTETDNTGGQVRGIWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:274) PRT-220 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQGVVYTKWLDGVNVDDHEFRKITDGNTEY YATPLLNGRGYYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPDKHGIIELPDGQLKLSDFLN TYESDHDYRDKSKLFDFISNNFNGPVWINKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKEVENGKLLTD NHSIRNKNEFSSKLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDEDGNVVAIYVTDSDDKKLTIGDER VGLKRYKVSYDDEGRARLTAYEETDNTGGEIRGLWTLDTGKQYWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:275) PRT-221 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:276) PRT-222 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDINRDNVDRELRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:277) PRT-223 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKENVVYTKWLDGVDVKDHDFRKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:278) PRT-224 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRLRLTAYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:279) PRT-225 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKENVVYTKWLDGVDVKDHDERKIVDGNIEY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRARLTAYEETDNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:280) PRT-226 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVDDHDERKIVDGNTEY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTNKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDEGRARLTAYEETDNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:281) PRT-227 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLYTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:282) PRT-228 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSDLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:283) PRT-229 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:284) PRT-230 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDNGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:285) PRT-231 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRARLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:286) PRT-232 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKEAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:287) PRT-233 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWILDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:288) PRT-234 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIVDGNIAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDDGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:289) PRT-235 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETDNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:290) PRT-236 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVDDHDERKIVDGNIAY YATPLLNGRGFYDINKDENRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:291) PRT-237 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNIEY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDFISNNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILTN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWILDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:292) PRT-238 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIVDGGIAY YATPLLNGRGFYDINKDENRDSDLCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDYISNNFNGPVWTDKLLDNYINGYGYNYKYGRTIEDPTKNTSKINFFKEVFNEKILIN NHSIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDENRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:293) PRT-239 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIVDGGTAY YATPLLNGRGFYDINKDENRDSLLCSAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLN TYESDHGYRDKSKLFDYISNNENGGLWTDKLLDNYINGYGYNKKYGRTIEDPTKNTSKINFFKEVENEKILIN NHQIRNQNEFSVLLSEALYTGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDNNRLRLTAYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:294) PRT-240 MEVVEVWPYGQNPNGKTEILSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGDYAY YATPLLNGRGFYDINKDFNRDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDELN TYESDHGYRDKSKLFDFISNAFNGPVWADKLLDNYINGYGYNKKYGRTIEDPTKNTSKFNFFKEVFNEKILTN NHQIRNQNEFSVLLSEALYTGKAIGLAYGPGGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDER VGLKRYKISTDDNNRLRLTTYEETHNTGAQIRGLETLDTGKYAWADYFDKTEQTGTDQAEQLEHHHHHH (SEQIDNO:295) PRT-241 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVIN LWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:296) PRT-242 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVIN LWGADFDSNGNLKAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:297) PRT-243 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANGRINHVIN LWGADFDSNGNLKAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:298) PRT-244 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVIN LWGADFDSNGNLKAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:299) PRT-245 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANGRINHVIN LWGADFDSNGNLKAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:300) PRT-246 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMFDVKEAIDTKNHQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVIN LWGADFDSNGNLKAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:301) PRT-247 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLE EHPEKQKINFNGEQMEDVKEAIDTKNHQLDSKLFEYFLEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRINHVIN LWGADFDSNGNLKAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWNQT N(SEQIDNO:302) PRT-248 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:303) PRT-249 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:304) PRT-250 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:305) PRT-251 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:306) PRT-252 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:307) PRT-253 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNKSIGMKKYFVGVNSDGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:308) PRT-254 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNKSIGMKKYPVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:309) PRT-255 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVGINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:310) PRT-256 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVGINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:311) PRT-257 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:312) PRT-258 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFLEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:313) PRT-259 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFEYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:314) PRT-260 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:315) PRT-261 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIYVTDSDTNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:316) PRT-262 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:317) PRT-263 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIAVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:318) PRT-264 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDINPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:319) PRT-265 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFEYFLEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:320) PRT-266 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:321) PRT-267 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:322) PRT-268 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:323) PRT-269 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:324) PRT-270 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:325) PRT-271 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:326) PRT-272 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFLEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:327) PRT-273 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:328) PRT-274 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:329) PRT-275 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFDYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIYVTDSDTNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:330) PRT-276 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:331) PRT-277 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFLEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIAVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:332) PRT-278 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:333) PRT-279 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFLEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDTNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:334) PRT-280 MVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVGINHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:335) PRT-281 MVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRIGHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:336) PRT-282 MVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRLNHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:337) PRT-283 MVTSVWTKGVTPPAKFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYERDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRISHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:338) PRT-284 MVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRLNHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:339) PRT-285 MVTSVWTKGVTPPAKFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPGLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRISHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:340) PRT-286 MVTSVWTKGVTPPAKFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYERDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRISHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:341) PRT-287 MVTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRIGHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:342) PRT-288 MVTSVWTKGVTPPAKFTQGEDVFHAPYDANQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLK KHPDKQKIMFGDQELLDVRKVINTKGDQTNSELFNYERDKAFPNLSARRIGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQEKDRRGGIFDAVETRGDQSKLLTSRHDFKEKNLKEISDLIKKELTEGKALGLSHTYANVRIGHV INLWGADFDSNGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN QTN(SEQIDNO:343) PRT-289 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVGINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:344) PRT-290 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:345) PRT-291 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRLNHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:346) PRT-292 MVTSVWTKGVTPPADFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYERDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:347) PRT-293 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRLNHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:348) PRT-294 MVTSVWTKGVTPPADFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYERDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:349) PRT-295 MVTSVWTKGVTPPADFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:350) PRT-296 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:351) PRT-297 MVTSVWTKGVTPPADFTQGEDVFHAPYDANQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:352) PRT-298 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYERDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVGINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:353) PRT-299 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:354) PRT-300 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRLNHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:355) PRT-301 MVTSVWTKGVTPPTDFIKGEDVFHAPYDAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:356) PRT-302 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRLNHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:357) PRT-303 MVTSVWTKGVTPPTDFIKGEDVFHAPYDAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:358) PRT-304 MVTSVWTKGVTPPTDFIKGEDVFHAPYDAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:359) PRT-305 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYERDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:360) PRT-306 MVTSVWTKGVTPPTDFIKGEDVFHAPYDAGQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYERDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:361) PRT-307 MQITSVWTKGVTPLTPEQFRKNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTILLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLS(SEQIDNO:362) PRT-308 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSLGK DIWQKLS(SEQIDNO:363) PRT-309 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFGNQELFDLKAAIDTKDSQTNSQLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DQWQKLS(SEQIDNO:364) PRT-310 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DQWQKLS(SEQIDNO:365) PRT-311 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQEWFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV PKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYAVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLS(SEQIDNO:366) PRT-312 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFGNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANPSIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLS(SEQIDNO:367) PRT-313 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFGNQELFDLKAAIDTKDSQTNSQLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGELEAIYVTDSDANPSIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLS(SEQIDNO:368) PRT-314 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFGNQELFDLKAAIDTKDSQTNSQLFDYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGELEAIYVTDSDANPSIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DQWQKLS(SEQIDNO:369) PRT-315 MQITSVWTKGVTPLTPEQFRENNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGELEAIYVTDSDANPSIGMKKYFVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLS(SEQIDNO:370) PRT-316 MTITSVWTKGVTPPTPEDFRKNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:371) PRT-317 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLENYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSLGQ DIWQKLS(SEQIDNO:372) PRT-318 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSLGQ DIWQKLS(SEQIDNO:373) PRT-319 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSLGQ DIWQKLS(SEQIDNO:374) PRT-320 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:375) PRT-321 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL PKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYAVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:376) PRT-322 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:377) PRT-323 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL PKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYAVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:378) PRT-324 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:379) PRT-325 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:380) PRT-326 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:381) PRT-327 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:382) PRT-328 MTITSVWTKGVTPPTPEDFRKNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLENYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:383) PRT-329 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSLGQ DIWQKLS(SEQIDNO:384) PRT-330 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:385) PRT-331 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:386) PRT-332 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFNYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL PKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYAVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:387) PRT-333 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:388) PRT-334 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:389) PRT-335 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLEDYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:390) PRT-336 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPGLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANPSIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:391) PRT-337 MTITSVWTKGVTPPTPEDERKNNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:392) PRT-338 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSLGQ DIWQKLS(SEQIDNO:393) PRT-339 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:394) PRT-340 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:395) PRT-341 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNL PKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGNLEAIYVTDSDANASIGMKKYAVGVNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:396) PRT-342 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGNLEAIYVTDSDANPSIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:397) PRT-343 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGELEAIYVTDSDANPSIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:398) PRT-344 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGELEAIYVTDSDANPSIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:399) PRT-345 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFDAEGELEAIYVTDSDANPSIGMKKYFVGRNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:400) PRT-346 MSQTEDSESLQRLRDIEDFQAEKEMQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQVRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:401) PRT-347 MSQTEDSESLQRLRDIEDFQAEKEMQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQVRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:402) PRT-348 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQVRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:403) PRT-349 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGLYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQVRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:404) PRT-350 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQVRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:405) PRT-351 MSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQIRGLWILDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:406) PRT-352 MSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNSKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQIRGLWILDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:407) PRT-353 MSQTEDSESLQRLRDIEDFQAEKEMQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNSKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQVRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:408) PRT-354 MSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQIRGLWILDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:409) PRT-355 MSQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDHGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRLIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGTRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDENRLRLT AYEETHNTGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQAEQ(SEQIDNO:410) PRT-356 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:411) PRT-357 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:412) PRT-358 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:413) PRT-359 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGLYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:414) PRT-360 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:415) PRT-361 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:416) PRT-362 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNSKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:417) PRT-363 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGWYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNSKYGRTIEDPTKNTSKINFFKEVFNEKILTNNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:418) PRT-364 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRELRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:419) PRT-365 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRELRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRLIEDPTKNTSKINFFKEVENEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGTRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:420) PRT-366 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGFYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRELRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:421) PRT-367 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGWYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:422) PRT-368 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGWYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:423) PRT-369 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGLYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:424) PRT-370 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGWYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:425) PRT-371 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGFYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:426) PRT-372 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNSAYYATPLLNGRGFYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNSKYGRTIEDSTKNTSKINFFKEVFNEKILTNNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:427) PRT-373 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGWYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNSKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQVRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:428) PRT-374 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:429) PRT-375 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRLIEDSTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGTRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:430) PRT-376 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:431) PRT-377 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFLEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:432) PRT-378 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPSLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:433) PRT-379 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLLNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:434) PRT-380 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANARINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:435) PRT-381 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:436) PRT-382 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYVVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:437) PRT-383 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:438) PRT-384 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPNLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:439) PRT-385 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:440) PRT-386 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIAVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:441) PRT-387 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:442) PRT-388 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDTLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:443) PRT-389 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFKGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:444) PRT-390 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:445) PRT-391 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:446) PRT-392 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:447) PRT-393 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:448) PRT-394 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSEASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT N(SEQIDNO:449) PRT-395 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPTLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:450) PRT-396 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTTANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:451) PRT-397 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVGINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:452) PRT-398 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYDVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:453) PRT-399 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYVVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:454) PRT-400 MVTSVWTKGVTPPADFTQGEDVFHAPYDANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:455) PRT-401 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKEFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:456) PRT-402 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRLNHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:457) PRT-403 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRISHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:458) PRT-404 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRIGHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:459) PRT-405 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYGVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:460) PRT-406 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNRKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:461) PRT-407 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIIFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:462) PRT-408 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVFPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:463) PRT-409 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGVQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:464) PRT-410 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:465) PRT-411 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSRASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:466) PRT-412 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNAAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTN(SEQIDNO:467) PRT-413 MTITSVWTKGVTPPTPEDFRENNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:468) PRT-414 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:469) PRT-415 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFLDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:470) PRT-416 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL PKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:471) PRT-417 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGELIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:472) PRT-418 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYAVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:473) PRT-419 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DQWQKLS(SEQIDNO:474) PRT-420 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:475) PRT-421 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:476) PRT-422 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANPSIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:477) PRT-423 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGRNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:478) PRT-424 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSLGQ DIWQKLS(SEQIDNO:479) PRT-425 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPGLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:480) PRT-426 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYERDKAFPNLSARQLGVFPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:481) PRT-427 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:482) PRT-428 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDTNASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:483) PRT-429 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDARASIGMKKYFVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLS(SEQIDNO:484) PRT-430 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNSAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILTNNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:485) PRT-431 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS ENFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:486) PRT-432 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNSKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:487) PRT-433 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLIEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:488) PRT-434 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHGLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:489) PRT-435 MSQTEDSESLQRLRDIEDFQAEKEKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:490) PRT-436 MSQTEDSESLQRLRDIEDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:491) PRT-437 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNEAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:492) PRT-438 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGLYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:493) PRT-439 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRLIEDPTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:494) PRT-440 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNELSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:495) PRT-441 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGTRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:496) PRT-442 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGFYDINKDEN RDNDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:497) PRT-443 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDERKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDEQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWILDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:498) PRT-444 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLFDFIS NNFNKPVWTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKEVFNEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:499) PRT-445 MSQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIVDGNIAYYATPLLNGRGFYDINKDEN RDSDKCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIELPDGQLKLSDFLNTYESDDGYRDKSKLEDFIS NNFNGPVWTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKEVENEKILINNHSIRNQNEFSVLLSEALY TGKAIGLSYGPAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKLTIGDERVGLKRYKISTDDEGRLRLT AYEETHNTGGQIRGLWTLDTGKQAWADYFDKTEQTGTDQAEQ(SEQIDNO:500) PRT-446 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMFDVKEAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:501) PRT-447 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMEDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLTNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:502) PRT-448 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMFDVKEAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:503) PRT-449 MVTSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIE AYLKEHPEKQKINFNGEQMFDVKEAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALALSHTYANVRIN HVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:504) PRT-450 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIE AYLKEHPEKQKINFNGEQMFDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRIN HVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:505) PRT-451 MVTSVWTKGVTPPANFRKIVDGNIAYYHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIE AYLKEHPEKQKINFNGEQMFDVKEAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRIN HVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:506) PRT-452 MVTSVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMEDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:507) PRT-453 MVTSVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMEDVKEAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLTNHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:508) PRT-454 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMFDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTSRHDFKEKTLNEISQLIKQELTEGKALALSHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:509) PRT-455 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMFDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTSRHDLKNKTLNEISQLIKQELTEGKALALSHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:510) PRT-456 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMFDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLNEISQLIKQELTEGKALALSHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:511) PRT-457 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKINFNGEQMFDVKEAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVEGRGDQTKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:512) PRT-458 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:513) PRT-459 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:514) PRT-460 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:515) PRT-461 MVTSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYDITKTENGKDDLLCGAATAGNMLHWWFDQNKDQIE RYLKEHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRIN HVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:516) PRT-462 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIE RYLKEHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRIN HVINLWGADEDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:517) PRT-463 MVTSVWTKGVTPPANFRKIVDGNIAYYHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIE RYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRIN HVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:518) PRT-464 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:519) PRT-465 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVETRGDQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:520) PRT-466 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTSRHDFKEKTLNEISQLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:521) PRT-467 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTSRHDLKNKTLNEISQLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:522) PRT-468 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDLKNKTLNEISQLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:523) PRT-469 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKINFNGEQMEDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVEGRGDQTKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:524) PRT-470 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:525) PRT-471 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:526) PRT-472 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:527) PRT-473 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIE NYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSL TNHGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRIN HVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:528) PRT-474 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIE NYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSL TNHGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRIN HVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:529) PRT-475 MVTSVWTKGVTPPTNFRKIVDGNIAYYHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIE NYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSL TNHGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRIN HVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:530) PRT-476 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:531) PRT-477 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:532) PRT-478 MITSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTNRHDFKEKTLNEISQLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:533) PRT-479 MITSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTNRHDLKNKTLNEISQLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:534) PRT-480 MITSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMEDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTNHG PTPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLNEISQLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:535) PRT-481 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRQEKDPRGGIFDAVFGRGDQTKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQKIWNKT NLEHHHHHH(SEQIDNO:536) PRT-482 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKIIFNNQELFDLKAAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLTNHG PTPVKEGSKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:537) PRT-483 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKIIFNNQELFDLKAAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDKRGGIFDAVETRGVQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:538) PRT-484 MVTSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKDQIE AYLKEHPEKQKIIFNNQELFDLKAAIDTKDDQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRIN HVINLWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:539) PRT-485 MVTSVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKDQIEAYLK EHPEKQKIIFNNQELFDLKAAIDTKDDQTNSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALALSHTYANVRINHVIN LWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIEDDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:540) PRT-486 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKIIFNNQELFDLKAAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDKRGGIFDAVETRGVQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:541) PRT-487 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKIIFNNQELFDLKAAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDKRGGIFDAVETRGVQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:542) PRT-488 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKDQIE RYLKEHPEKQKIIFNNQELFDLKAAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSL TNHGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRIN HVINLWGADFDSEGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:543) PRT-489 MVTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKDQIERYLK EHPEKQKIIFNNQELFDLKAAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVLDMFINGYRLSLINHG PTPVKEGSKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHVIN LWGADFDSEGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:544) PRT-490 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:545) PRT-491 MVTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:546) PRT-492 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKEQIE NYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSELFNYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSL TNHGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRIN HVINLWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDI WNQTNLEHHHHHH(SEQIDNO:547) PRT-493 MVTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLK KHPEKQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLINHG PTPVKRGSKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISDLIKQELTEGKALGISHTYANVRINHVIN LWGADFDAEGNLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQT NLEHHHHHH(SEQIDNO:548) PRT-494 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:549) PRT-495 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:550) PRT-496 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:551) PRT-497 MVTSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIE AYLKKHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNV TKTQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:552) PRT-498 MVTSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIE AYLKKHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNV TKTQTTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:553) PRT-499 MVTSVWTKGVTPPADFRKIVDGNIAYYHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIE AYLKKHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNV TKTQTTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:554) PRT-500 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:555) PRT-501 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGDQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:556) PRT-502 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRQEQEKDKRGGIFDAVFGRGDQTKLLTSRHDFKEKGLNEISQLIKQELTEGKALGLSHTYANVRINHV INLWGADFDADGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWN KTNLEHHHHHH(SEQIDNO:557) PRT-503 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRQEQEKDKRGGIFDAVFGRGDQTKLLTSRHDLKNKGLNEISQLIKQELTEGKALGLSHTYANVRINHV INLWGADFDADGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWN KTNLEHHHHHH(SEQIDNO:558) PRT-504 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGDQSKLLTSRHDLKNKGLNEISQLIKQELTEGKALGLSHTYANVRINHV INLWGADFDADGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:559) PRT-505 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAFPNLSARRLGVMPDLVLDMFINGYYLNVTKTQ TTDVNRQEQEKDKRGGIFDAVFGRGDQTKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWN KTNLEHHHHHH(SEQIDNO:560) PRT-506 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:561) PRT-507 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:562) PRT-508 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:563) PRT-509 MITSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNV YKTQTTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:564) PRT-510 MITSVWTKGVTPPTDERKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNV YKTQTTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:565) PRT-511 MITSVWTKGVTPPAKFRKIVDGNIAYYHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNV YKTQTTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:566) PRT-512 MITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:567) PRT-513 MITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:568) PRT-514 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRQEQTKDRRGGIFDAVFGRGDQTKLLTERHDFKEKTLNEISQLIKQELTEGKALGLSHTYANVRINHV INLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWN KTNLEHHHHHH(SEQIDNO:569) PRT-515 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRQEQTKDRRGGIFDAVFGRGDQTKLLTERHDLKNKTLNEISQLIKQELTEGKALGLSHTYANVRINHV INLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWN KINLEHHHHHH(SEQIDNO:570) PRT-516 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGDQSKLLTERHDLKNKTLNEISQLIKQELTEGKALGLSHTYANVRINHV INLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:571) PRT-517 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKAFDGGDDLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAFPNLSARRLGVMPDLVLDMFINGYYLNVYKTQ TTDVNRQEQTKDRRGGIFDAVFGRGDQTKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQKIWN KTNLEHHHHHH(SEQIDNO:572) PRT-518 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIIFNNQELFDLKAAINTKGSQKNSELFNYFRDKAFPNLSARRLGVFPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:573) PRT-519 MVTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIIFNNQELFDLKAAINTKGSQKNSELFNYFRDKAFPNLSARRLGVFPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVETRGVQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:574) PRT-520 MVTSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKEYIE AYLKKHPEKQKIIFNNQELFDLKAAINTKGSQKNSELFNYFRDKAFPNLSARRLGVFPDLVLDMFINGYYLNV TKTQTTDVNRTYQEKDKRGGIFDAVETRGVQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSDGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:575) PRT-521 MVTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEYIEAYLK KHPEKQKIIFNNQELFDLKAAINTKGSQKNSELFNYERDKAFPNLSARRLGVFPDLVLDMFINGYYLNVTKTQ TTDVNRTYQEKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKGLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSDGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:576) PRT-522 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIIFNNQELFDLKAVINTKDSQTNSALFNYFKDKAFPNLSARRLGVFPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGVQSKLLTERHDFKEKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:577) PRT-523 MITSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIIFNNQELFDLKAVINTKDSQTNSALFNYFKDKAFPNLSARRLGVFPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGVQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:578) PRT-524 MITSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIIFNNQELFDLKAVINTKDSQTNSALFNYFKDKAFPNLSARRLGVFPDLVLDMFINGYYLNV YKTQTTDVNRTYQTKDRRGGIFDAVFTRGVQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVR INHVINLWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQ DIWNQTNLEHHHHHH(SEQIDNO:579) PRT-525 MITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEEIEAYLK KHPEKQKIIFNNQELFDLKAVINTKDSQTNSALFNYFKDKAFPNLSARRLGVFPDLVLDMFINGYYLNVYKTQ TTDVNRTYQTKDRRGGIFDAVFTRGVQSKLLTERHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVRINHV INLWGADFDSNGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEIKEDNIGAQVLGLFTLSTGQDIWN QTNLEHHHHHH(SEQIDNO:580) PRT-526 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPNLSTKHLGVMPDHVLD MFINGYYLSLGKHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:581) PRT-527 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPNLSTKHLGVMPDLVLD MFINGYYLSLGKHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADFNSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:582) PRT-528 MANQEIRYSEETPKTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPNLSTKHLGVMPDLVLD MFINGYYLSLGKHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:583) PRT-529 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINENGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPNLSTKHLGVMPDLVLD MFINGYYLSLGKHGPTPVKRGTKDPRGGIFDAVFTRGDQTKLLTARHDFKEKTLNEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:584) PRT-530 MANQEIRYSEETPKTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVMPDLVLD MFINGYYLSVGKHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:585) PRT-531 MANQEIRYSEDTPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIEAYLKKYPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFNYERDKAFPNLSTKHLGVMPDHVID MFINGYRLNLGNHGPTPVKNQTKDLRGGIFDAVFTRGDQSKLLTARHDFKEKTLKEISQLIKQELTEGKALAL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSSGQDIWQQTNLEHHHHHH(SEQIDNO:586) PRT-532 MANQEIRYSEETPKTITSIWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVMPDLVLD MFINGYYLSLGKHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:587) PRT-533 MANQEIRYSSDSEWANKKVWVYGITPPEEGAWKYSTYYLPWKKEYGWYDCNKRNPTADGMMCWAATASNLLHW WIAQNKEYIDLYGDKYKGPDKINFNGEQMFDVKEYIDPLDKPQESDIFQCFIDKSFADLSTKHEAGYGDAGIN WFIHGIIPSSPAHGPTPVKLDYPYNPAGYFKDVFPRGDGVVLLGNNGDFKELSKERFNETIKDALKNKKAIGL SIGPVNVRSSHVVTIWGAEFDENGDVSYIYMADNNDRWGVGCIRYQIVYEEGGTYTCYKTEIIPSDRPIPINR LVTLELGEEYWKQTNLEHHHHHH(SEQIDNO:588) PRT-534 MANQEIRYSSDSEWANKKVWVYGITPPEEGAWKYSTYYLPWKKEYGWYDCNKRNPTADGMMCWAATASNLLHW WIAQNKEYIDLYGDKYKGPDKINFNGEQMFDVKEYIDPLDKPQESDIFQCFIDKSFADLSTKHEAGYGDAGIN WFIHGIIPSSPAHGPTPVKLDYPYNPAGYFKDVFPRGDGVVLLGNNGDFKELSKERFNETIKDALKNKKAIGL SIGPVNVRSSHVVTIWGAEFDENGDVSYIYMADNNDNWGVGCIRYQIVYEEGGTYTCYKTEIIPSDRPIPINR LVTLELGEEYWKQTNLEHHHHHH(SEQIDNO:589) PRT-535 MANQEIRYSGDSEWANKKVWVYGITPPEEKAWFYSTYYLPWKKEYGWYDCNKRNPTADGMMCWAATASNLMHW WIAQNKEYIDLYGDKYKGPDKINFNGEQMFDVKEYIDPLDKPQESDIFQCFIDKAFADLSTKHEAGKGDEGIN WFIHGIIPSYPAHGPTPVKLRYPYNPAGYFKDVFPRGDGVVLLGNNGDFKELGKERFNETIKDALANKKGIGL SIGPVNVRSSHVVTMWGAEFDENGDVSYIYMADNNDRWGVGCIRYQIVYVEGGTYTCYKTEIIGSDRPIPINR LVTLELGEEYWKQTNLEHHHHHH(SEQIDNO:590) PRT-536 MANQEIRYSGDSEWANKKVWVYGITPAEEGAWLYSTYYLPWKKEYGWYDCNKRNPTADGMMCWAASASNLMHW WIAQNKRYIDLYGDRYKGPDKINFNGEQMFDVKEYIDPLDKPQESDIFQCFIDKSFADLSTKHEAGKGDEGIN WFIHGIIPSYPAHGPTPVKLRYPYNPAGYFKDVFPRGDGVVLGGNNGDFKELGKERFNETIKDALANKKGIGL SIGPVNVRKSHVETMWGAEFDENGDVSYIYMADNNDRWGVGCIRLQIVYVEGATYTCYKTEIIPSDRPIPINR LVTVELGEEYWKQTNLEHHHHHH(SEQIDNO:591) PRT-537 MANQEIRYSSDSEWANKKVWVYGITPPEEGAWFYSTYYLPWKKEYGWYDCNKRNPTADGMMCWAASASNLLHW WIAQNKEYIDLYGDKYKGPDKINFNGEQMFDVKEYIDPLDKPQESDIFQCFIDKSFADLSTKHEAGKGDAGIN WFIHGIIPSSPAHGPTPVKLRYPYNPAGYFKDVFPRGDGVVLLGNNGDFKELGKERFNETIKDALANKKGIGL SIGPVNVRSSHVVTIWGAEFDENGDVSYIYMADNNDRWGVGCIRYQIVYEEGGTYTCYKTEIIPSDRPIPINR LVTLELGEEYWKQTNLEHHHHHH(SEQIDNO:592) PRT-538 MANQEIRYSSDSEWANKKVWVYGITPPEEGAWKYSTYYLPWKKEYGWYDCNKRNPTADGMMCWAATASNLLHW WIAQNKEYIDLYGDKYKGPDKINFNGEQMFDVKEYIDPLDKPQESDIFQCFIDKSFADLSTKHEAGYGDEGIN WFIHGIIPSSPAHGPTPVKLRKPYNPAGYFKDVFPRGDGVKLLSNNGDFKELGKERFNETIKDALKNKKGIGL SIGPVNVRSGHVVTMWGAEFDENGDVSYIYIADNNDRWGVGCIRYQIVYEEGGTYTCYKTEIINEDRPIPINR LVTLELGEEYWKQTNLEHHHHHH(SEQIDNO:593) PRT-539 MANQEIRYSKNENPNVTIKWVHGIGEPTQAEKEKIEFYWYETNTTKFFNNRKVTHLGDSNQCWAKTASNMLHW WFEQNKENINKYIEKKNITGKINFNGEQMFDVKEGIDDNQEKEKSYIANTFRTKKAHNLSTKHKGDYIISGLA WYLYGLNNFKNAHGPTPVKKKPKFYGPALFKDVFNRGDGNTPIKEETDFKEYTKKEFEDILKEALDSKKAIGI NIYGSNVGYGHAITLWGAAFDEDNNIIAIYVVDNNFKFENRIFPYGIWYEKEGRPYLFNYEINSFVKNRYVGE ITTLDKGEAQWQETNLEHHHHHH(SEQIDNO:594) PRT-540 MANQEIRYSKNENPNVTIKWVHGIGEPTQAEKEKIEFYWYETNTTKFFNNRKVTHLGDSNQCWAKTASNMLHW WFVQNKENINKYIEKKNITGKINFNGEQMFDVKEGIDDNQEKEKSYIANTFRTKKAHNLSTKHKGDYIINGLA WYLYGLNNFKNAHGPTPVKKKPKFYGPALFKDVFNRGDGNTPIIEETDFKEYTKKEFEDTLSEALDSKKAIGI NIYGSNVDYGHAITLWGAAFDEDENIIAIYVVDNNFKFENRIFPYGIWYEKEGRPYLFNYEINSFVKNRYVGE ITTLDKGEAQWQETNLEHHHHHH(SEQIDNO:595) PRT-541 MANQEIRYSKNENPNVTIKWVHGIGEPTQAEKEKIEFWWYETTTTKFFNNRKVDHLGDGNQCWAKTDSNMLHW WFVQNEENINQYIAKKNITGKINFNGEQMFDVKEGIDDNQEKEKSYIANTFRTKKAHNLSTKHKGDYIINGLS WYLYGLNNFKIAHGPTPVKKKPKFYGPALFKDVFSRGDGNTPIIVETDFKEYTKKEFEDTLSAALDSKKAIGI NIYGSNVDYQHAITLWGAAFDEEENIIAIYVVDNNFKFENRIFPYGIWYQKEGRPYLFNYEINSFVKNRYVGE VTTLDKGEAQWQETNLEHHHHHH(SEQIDNO:596) PRT-542 MANQEIRYSKNENPNVTIKWVHGIGEPTQAEKEKIEFWWYETTTTKFFNNRKVDHLGDGNQCWAKTDSNMLHW WFVQNEENINQYIEKKNITGKINFNGEQMFDVKEGIDDNQEPEKSYIANTERTKKAHNLSTKHKGDYIINGLS WYLYGLNNFKNAHGPTPVKKKPKFYGPALFKDVFNRGDGNTPIIVETDFKEYTKKEFEDTLSAALDSKKAVGI NIYGSNVDYQHAITLWGAAFDEEENIIAIYVVDNNFKFENRIFPYGIWYQKEGRPYLFNYEINSFVKNRYVGE ITTLDKGEAQWQETNLEHHHHHH(SEQIDNO:597) PRT-543 MANQEIRYSKNENPNVTIKWVHGIGEPTQSEKEKIEFWWYETTTTKFFNNRKVDPLGDGNQCWAKTDSNMLHW WFVQNEENINQYIEKKNITGKINFNGEQMEDVKEGIDDNQEPEKSYIANTFRTKKAHNLSTKHKGDYIINGLS WYLYGLNNFKNAHGPTPVKKKPKFYGPALFKDVFNRGDGNTPIIVETDFKEYTKKEFEDTLSAALDSKKAIGI NIYGSNVDYQHAITLWGAAFDEEENIIAIYVVDNNFKFENRIFPYGIWYEKEGRPYLFNYEINSFVKNRYVGE ITTLDKGEAQWQETNLEHHHHHH(SEQIDNO:598) PRT-544 MANQEIRYSKNENPNVTIKWVHGIGEPTQAEKEKIEFWWYETTTTKFFNNRKVDHLGDGNQCWAKTDSNMLHW WFVQNEENINQYIAKKNITGKINFNGEQMEDVKEGIDDNQEKEKSYIANTFRTKKAHNLSTKHKGDYIINGLS WYLYGLNNFKIAHGPTPVKKKPKFYGPALFKDVENRGDGNTPIIVETDFKEYTKKEFEDTLSAALDSKKAIGI NIYGSNVDYQHAITLWGAAFDEEENIIAIYVVDNNEKFENRIFPYGIWYQKEGRPYLFNYEINSFVKNRYVGE VITLDKGEAQWQETNLEHHHHHH(SEQIDNO:599) PRT-545 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:600) PRT-546 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:601) PRT-547 MANQEIRYSEETPKTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:602) PRT-548 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQTKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:603) PRT-549 MANQEIRYSEDTPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIEAYLKKYPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFNYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKNQTKDPRGGIFDAVETRGDQSKLLTARHDFKEKTLKEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:604) PRT-550 MANQEIRYSEETPKTITSIWTKGVTPPTDFIKNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:605) PRT-551 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:606) PRT-552 MANQEIRYSEETPKTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:607) PRT-553 MANQEIRYSEETPKTITSIWTKGVTPPTDFIKNEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQTKLLTERHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:608) PRT-554 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFNYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKDGTKDPRGGIFDAVFTRGDQTKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEDDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:609) PRT-555 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELQEGKALGL SHTYANVRINHVINLWGADFDSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:610) PRT-556 MANQEIRYSKAKPKVITSVWTKGVTPPTQFTYNEDVFHAPYLPNQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLFNYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEQNKDPRGGIFDDVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELKEGKALGL SHTYANVRINHVINLWGADFDAEGNLVAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEKTNLEHHHHHH(SEQIDNO:611) PRT-557 MANQEIRYSEEDGKTITSVWTKGVTPPTDFQKNEDVYHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKDGTKDPRGGIFDAVFTRGDQTKLLTERHDFKEKTLNEISDLIKQELQEGKALGL SHTYANVRINHVINLWGADEDSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:612) PRT-558 MANQEIRYSEETPSTITSIWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTEIENYLTKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQTKLLTARHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:613) PRT-559 MANQEIRYSEETPKTITSIWTKGVTPPTDFIKTEDVLHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKDGTKDPRGGIFDAVFTRGDQTKLLTERHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEDDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:614) PRT-560 MANQEIRYSEETPKTITSVWTKGVTPPTDFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:615) PRT-561 MANQEIRYSEETPSTITSVWTKGVTPPTQFIYNEDVFHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLENYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:616) PRT-562 MANQEIRYSKATPSHITSVWTKGVTPPEQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:617) PRT-563 MANQEIRYSEATPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVFTRGDQSKLLTARHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:618) PRT-564 MANQEIRYSEATPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:619) PRT-565 MANQEIRYSEATPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:620) PRT-566 MANQEIRYSEETPSTITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:621) PRT-567 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:622) PRT-568 MANQEIRYSEATPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKTQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVETRGDQSKLLTARHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGHVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:623) PRT-569 MANQEIRYSKATPSHITSVWTKGVTPPEQFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:624) PRT-570 MANQEIRYSEATPSHITSVWTKGVTPPEQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIEAYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFNYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:625) PRT-571 MANQEIRYSEETPSTITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTENGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENAEGNLEAIYVTDSDSNASIGMKKYYVGVNAAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:626) PRT-572 MANQEIRYSEATPSHITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:627) PRT-573 MANQEIRYSEETPSTITSVWTKGVTPPTQFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFSYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:628) PRT-574 MANQEIRYSEETPKTITSVWTKGVTPPTDFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:629) PRT-575 MANQEIRYSEETPKTITSVWTKGVTPPTDFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:630) PRT-576 MANQEIRYSKATPSTITSVWTKGVIPPENFIYNEDVLHAPYLANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:631) PRT-577 MANQEIRYSKATPSTITSVWTKGVTPPENFIYNEDVLHAPYLANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:632) PRT-578 MANQEIRYSKATPKVITSVWTKGVTPPEDFTYNEDVFHAPYLPNQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQNKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELKEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:633) PRT-579 MANQEIRYSKATPSHITSVWTKGVTPPENFIYNEDVLHAPYLPNQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQNKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLNEISQLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:634) PRT-580 MANQEIRYSEETPKTITSVWTKGVTPPTDFIKNEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEEIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELQEGKALGL SHTYANVRINHVINLWGADEDSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:635) PRT-581 MANQEIRYSKATPKTITSVWTKGVIPPENFIYNEDVLHAPYLANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKEHPEKQKINFNGEQMEDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:636) PRT-582 MANQEIRYSKAKPKVITSVWTKGVTPPTQFTKNEDVFHAPYLANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLFNYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQNKDPRGGIFDDVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELKEGKALGL SHTYANVRINHVINLWGADEDAEGNLVAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEKTNLEHHHHHH(SEQIDNO:637) PRT-583 MANQEIRYSKAKPKVITSVWTKGVTPPTQFTKNEDVFHAPYLANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTNSKLENYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKEQNKDPRGGIFDDVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELKEGKALGL SHTYANVRINHVINLWGADFDAEGNLIAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEDDNIGAQVLG LFTLSTGKDIWEKTNLEHHHHHH(SEQIDNO:638) PRT-584 MANQEIRYSEETPKTITSVWTKGVTPPTNFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:639) PRT-585 MANQEIRYSKATPSTITSVWTKGVTPPEQFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTNSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEQTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:640) PRT-586 MANQEIRYSEETPKTITSVWTKGVTPPTDFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWEQTNLEHHHHHH(SEQIDNO:641) PRT-587 MANQEIRYSEETPKTITSVWTKGVTPPTDFIYNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIERYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADENSEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGKDIWEQTNLEHHHHHH(SEQIDNO:642) PRT-588 MRNQTTTYSEVTPSHITSVWTKGVTPPEQFIQGEDVFHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKIMFNNEEMFDLREAINTKDSQTDSALFSYFKDKAFPNLSARRLGVMPDHVLD MFINGYYLNVGNTDKTDVNRGTKDLRGGIFDAVETRGDQSKLLTARHDLKNKTLKEISDLIKQELTEGKALAL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKKIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:643) PRT-589 MRNQTTTYSEVTPSHITSVWTKGVTPPEQFIQGEDVFHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINENNEEMFDVREAINTKDSQTDSALFSYFKDKAFPYLSAKHLGVFPDHVID MFINGYRLSLTNHDKTDVNRGTKDPRGGIFDAVFTRGDQSKLLTARHDFKNKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKKIEGDNIGAQVLG LFTLSTGQDIWQQTNLEHHHHHH(SEQIDNO:644) PRT-590 MANQEIRYSEETPSTVTSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:645) PRT-591 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIKNYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:646) PRT-592 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKNSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:647) PRT-593 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDHQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:648) PRT-594 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQLDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:649) PRT-595 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMFDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVETRGDQSKLLTSRHDFKEKNLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:650) PRT-596 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:651) PRT-597 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNANGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:652) PRT-598 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:653) PRT-599 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIKGDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:654) PRT-600 MANQEIRYSEETPSTITSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIENYLKKHPEKQKINFNGEQMEDVKEAIDTKDSQTDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLNEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEGDNIGAQVLG LFTLSTGQDSWNQTNLEHHHHHH(SEQIDNO:655) PRT-601 MANQEIRYSEETPSTVTSVWTKGVTPPTDFIQNEDVLHAPYIANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKEQIKNYLKKHPEKQKINFNGEQMEDVKEAIDTKNHQLDSALFEYFKDKAFPYLSTKHLGVFPDHVID MFINGYRLSLINHGPTPVKRGTKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLNEISDLIKKELTEGKALGL SHTYANVRINHVINLWGADFNANGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEIKGDNIGAQVLG LFTLSTGQDSWNQTNLEHHHHHH(SEQIDNO:656) PRT-602 MANQEIRYSEVTPYHITSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHW WFDQNKDQIERYLEEHPEKQKINFNGEQMEDVKEAIDTKDSQTDSKLFEYFKEKAFPYLSTKHLGVFPDHVID MFINGYRLSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISDLIKQELTEGKALGL SHTYANVRINHVINLWGADFDSEGNLKAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKEIEEDNIGAQVLG LFTLSTGQDIWNQTNLEHHHHHH(SEQIDNO:657) PRT-603 MQITTVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNGGLNDISTIIKQELQSGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:658) PRT-604 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDDVFGKGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:659) PRT-605 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFEQNKTEIE AYLSKYGDTQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:660) PRT-606 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPDKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:661) PRT-607 MQITSVWTYGVKPLTPEQFRYNNEDVIHAPYLEHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:662) PRT-608 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDADEKIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:663) PRT-609 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDRGDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQGGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDADEKIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:664) PRT-610 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGINAHGHVAISAYKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:665) PRT-611 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARYDLYNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:666) PRT-612 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRAAINSKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:667) PRT-613 MQITTVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAISTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDDVFTRGDQTTLLTARHDLKNGGLNDISTIIKQELTNGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANARIGMKKYGVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:668) PRT-614 MQITSVWTKGVKPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDDVFTRGDQTTLLTARHDLKNGGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVIDSDANASIGMKKYKVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:669) PRT-615 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVENRGDQTTLLTARHDLKNKGLNDISTIIKQELSSGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANSNIGMKKYKVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:670) PRT-616 MQITTVWTKGVTPLTPEQFRYNNEDVIHAPYLPHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDRDKRGGIFDAVENRGDQTTLLTARHDLKNKGLNDISTIIKQELSSGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:671) PRT-617 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLPHQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINSKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDPDKRGGIFDDVFKEGDQTTLLTARHDLKNGGLNDISTIIKQELQSGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANQSIGMKKYKVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:672) PRT-618 MQITSVWTKGVIPLTPEQFRYNNEDVIHAPYLPHQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDRDKRGGIFDHVFGRGDQTTLLTARHDLKNGGLNDISTIIKQELQSGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANSSIGMKKYYVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:673) PRT-619 MQITTVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNGGLEDISTIIKQELKNGRALALSHTYANVS ISHVINLWGADFNAEGNLSAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:674) PRT-620 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKTLKEISDIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:675) PRT-621 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKTLNEISQIIKQELSSGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:676) PRT-622 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKTLKEISDIIKQELQSGRALALSHTYANVS ISHVINLWGADENSEGNLIAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:677) PRT-623 MQITTVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNGTLNEISQIIKQELQSGRALALSHTYANVS ISHVINLWGADFNAEGNLIAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:678) PRT-624 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRDYDDKDKRGGIFDDVFGKGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:679) PRT-625 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPEDDKDKRGGIFDHVFTRGDQSTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:680) PRT-626 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPPDDKDKRGGIFDHVFNRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:681) PRT-627 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKYGETQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVIDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:682) PRT-628 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGQ DIWQQLSLEHHHHHH(SEQIDNO:683) PRT-629 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKYPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:684) PRT-630 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE NYLKKYPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGQ EIWEQLSLEHHHHHH(SEQIDNO:685) PRT-631 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEID NYLKKYPDKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWKKLSLEHHHHHH(SEQIDNO:686) PRT-632 MQITSVWTYGVTPLTPEQFRYNNYEVIHAPYKEGQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADENAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:687) PRT-633 MQITSVWTKGVTPLTPEQFINNNEDVIHAPYKANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:688) PRT-634 MQITSVWTKGVTPLTPEQFRYNNYDVIHAPYKPNQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:689) PRT-635 MQITSVWTKGVTPLTPDQFTNQGEDVIHAPYTPNQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:690) PRT-636 MQITSVWTKGVTPLIMDQFRNYNYDVIHAPYKPGQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:691) PRT-637 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGGDGLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQKGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDAGNGIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:692) PRT-638 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKLNDTGDGLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQKGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSNAGNGIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:693) PRT-639 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDADASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:694) PRT-640 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDADEKIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:695) PRT-641 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTMNGKDDLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQRGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDARENIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:696) PRT-642 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFNRGDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQGGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDADEKIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:697) PRT-643 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYKVGYNKDGRVAISAYKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:698) PRT-644 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGKNASGHVAISAKKIEDENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:699) PRT-645 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADENAEGNLEAIYVTDSDANASIGMKKYYVGYNKSGRVAISAYKITDENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:700) PRT-646 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTETTDLYGKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:701) PRT-647 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTNRYDLYDKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:702) PRT-648 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQYLFDLKAAIDTKDSQTNSQLFNYFRDKAFGNLSARQLGVMPDLVLDMFINGYYLNV NKTQSTDVNRPYQKPDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:703) PRT-649 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQYLFDLKAAIDTKDSQTNSQLFNYFRDKAFGNLSARQLGVMPDLVLDMFINGYKLKV NKTQSTDVNRPYQKPDNFGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:704) PRT-650 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQKLFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV TKTQSTDVNRPYQTKDPRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:705) PRT-651 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFGNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQTRDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:706) PRT-652 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHGTANGG YSHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENKGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:707) PRT-653 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYGNVR SSHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENVGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:708) PRT-654 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTTGNVS YSHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENVGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:709) PRT-655 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHKTGNGG SSHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGEDVGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:710) PRT-656 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKRAINDKDSQQNSELFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:711) PRT-657 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLREAINTKDSQTDSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:712) PRT-658 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRKAINTKDSQTNSALFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:713) PRT-659 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLREAINTKDDQKDSKLFNYFREKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:714) PRT-660 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRKAINTKDDQKESALFNYFRKKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:715) PRT-661 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKKAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGINAAGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:716) PRT-662 MQITSVWTKGVTPLTPEQFRYNNEDVFHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTLIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINASGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:717) PRT-663 MQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLAHQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKEAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTKLLTARHDLKNKGLNEISTLIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGINASGHVAISAKKIEGENIGAQVLGLFTLSTGK DIWQKLSLEHHHHHH(SEQIDNO:718) PRT-664 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLPHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRAAINTKDSQTNSALFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNDISTLIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDSDASIGMKKYYVGINASGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:719) PRT-665 MQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLSNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYYVGINASGHVAISAKKIEGEVIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:720) PRT-666 MQITSVWTKGVTPPTPEQFRNNNEDVFHAPYLANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKTEIE AYLKKHPEKQKIIFNNQELFDLKKAIDTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV TKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTSRHDLKNKGLNEISDLIKQELTEGKALALSHTYANVS INHVINLWGADFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNASGKVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:721) PRT-667 MQITSVWTKGVTPLTPEQFRYNNEDVFHAPYLAHQGWYDITKAFNGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIIFNNQELFDLRKAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL NKTQSTDVNRPYQDKDKRGGIFDHVFTRGDQTTLLTARHDLKNKTLNDISQLIKQELQEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDSDASIGMKKYFVGKNASGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:722) PRT-668 MQITSVWTKGVTPLTPEQFRYNNYDVFHAPYLAGQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRKAINTKDSQTNSELFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFNRGDQTKLLTARHDLKNKGLNDISTLIKQELSSGRALALSHTTANVS ISHVINLWGADFNAEGNLEAIYVTDSDDDSNIGMKKYKVGINASGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:723) PRT-669 MQITSVWTKGVTPPTPEQFINNNEDVFHAPYLANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKEQIE AYLKKHPEKQKIIFNNQEMFDLKKAIDTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQTKDKRGGIFDAVFTRGDQTKLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFNAEGNLIAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKKIEGDNIGAQVLGLFTLSSGQ DIWQKLSLEHHHHHH(SEQIDNO:724) PRT-670 MQITSVWTKGVTPLTPEQFRNNNEDVFHAPYLPNQGWYDITKAFNGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKYPEKQKIIFNNQELFDLRKAINTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDHVLDMFINGYYLNV GKTQSTDVNRPYQDKDKRGGIFDHVFNRGDQTKLLTARHDLKNKTLNDISTLIKQELSSGKALALSHTYANVG ISHVINLWGADFNAEGNLEAIYVTDSDDRASIGMKKYYVGRNASGHVAISAKKIEGENLGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:725) PRT-671 MQITTVWTKGVTPPTPEQFRNNNEDVFHAPYLPHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKYPEKQKIIFNNQELFDLRKAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDHVLDMFINGYYLNV FKTQSTDVNRPYQTRDKRGGIFDAVENRGDQTTLLTERHDLYNKGLDDISTLIKQELSSGKALGLSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDDDASIGMKKYYVGKNASGHVRISAKKIEGENIGAQVLGLFTLSTGK DIWQKLSLEHHHHHH(SEQIDNO:726) PRT-672 MQITSVWTKGVTPPTPEQFTYQNEDVFHAPYIANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE NYLKKHPEKQKIIFNNQEMFDLRKAINTKDSQTNSALFEYFRDKAFPNLSARQLGVMPDHVLDMFINGYYLNV TKTQSTDVNRPYQTKDKRGGIFDHVFTRGDQSKLLTARHDLKNKTLNEISDLIKQELTEGKALALSHTYANVR INHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYFVGVNSSGKVAISAKKIEDDNIGAQVLGLFTLSSGQ DIWEQLSLEHHHHHH(SEQIDNO:727) PRT-673 MQITSVWTKGVTPPTPEQFRYYNEDVLHAPYKPHQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTQIE AYLKKYPEKQKIIFNNQKMFDLRKAINTKDSQTNSALFSYFKDKAFPNLSARQRGVMPDLVLDMFINGYYLNV GKTQSTDVNRPYQTRDKRGGIFDHVFGRGDQTKLLTARHDLKNKTLNEISQLIKQELSEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDSDAKIGMKKYYVGKNASGKVAISAKKIEGENIGAQVLGLYTLSTGK DIWQKLSLEHHHHHH(SEQIDNO:728) PRT-674 MQITSVWTKGVTPPTMEQFRYNNYDVFHAPYLPGQGWYDITKAFDGGDNLLCGAATAGNMLHWWFDQNKEEIE AYLSKYPEKQKIIFNNQELFDLRKAINSKDSQTNSELFNYFRDKAFGNLSARQKGVMPDLVLDMFINGYYLNL NKTQSTDVNRPYQDPDKRGGIFDDVFKEGDQTKLLTARHDLSNGGLDDISTIIKQELQSGRALALSHTYANVS YSHVINLWGADFDAEGNLEAIYVTDSDDDQSIGMKKYKVGKNASGHVRISAKKIEDENIGAQVLGLFTLSLGK EIWQKLSLEHHHHHH(SEQIDNO:729) PRT-675 MQITSVWTKGVTPPTMDDFTINGEDVFHAPYVANQGWYDITKTFNGKDDLLCGAATAGNMLHWWFDQNKEQIE RYLKKHPEKQKIIFNNQEMFDLKEAINTKDSQTDSKLENYFRDKAFPNLSARQLGVMPDHVLDMFINGYYLNL TKTQSTDVNRPEDTKDLRGGIFDHVFTRGDQSKLLTARHDLKNKTLKEISDLIKQELTEGKALGLSHTYANVR ISHVINLWGADFDAEGNLEAIYVTDSDSNASIGMKKYYVGVNSAGKVAISAKKIEGDNIGAQVLGLYTLSTGK DIWQKLSLEHHHHHH(SEQIDNO:730) PRT-676 MQITSVWTKGVTPPTMDQFTNYNYDVFHAPYKPGQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE NYLKKHPEKQKIIFNNQKMFDLRKAINTKDSQTNSALFNYFKDKAFPNLSARQKGVMPDLVLDMFINGYYLNL GKTQSTDVNREYQTKDSRGGIFDDVFGRGDQTKLLTARHDLYNGGLNDISQLIKQELSSGKALGLSHTYANVR YSHVINLWGADFDEEGNLEAIYVTDSDDDASIGMKKYYVGKNASGKVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:731) PRT-677 MQITSVWTKGVIPPTMDQFRYNNYDVFHAPYLPHQGWYDITKTFDGGDNLLCGAATAGNMLHWWFDQNKEYIE NYLKKYPEKQKIIFNNQELFDLRKAINTKDSQTNSELFNYFRDKAFGNLSARQKGVMPDLVLDMFINGYYLNL FKTQSTDVNRPNDTRDKRGGFFDHVFGRGDQTKLLTARHDLYNGGLSDISQLIKQELQSGKALAISHTYGNVS SSHVINLWGADFDAEGNLEAIYVTDSDDRSSIGMKKYYVGINASGKVAISAKKIEGENVGAQVLGLFTLSSGK EIWKKLSLEHHHHHH(SEQIDNO:732) PRT-678 MQITTVWTKGVTPLTPEQFRYNNEEVIHAPYKAGQGWYDITKVFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKRAIDDKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDPDKRGGIFDDVFGKGDQTTLLTARHDLKNLGLEDISTIIKQELRNGRALALSHTYANVS ISHVINLWGADENAEGNLSAIYVTDSDANNSIGMKKYKVGYNAHGRVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:733) PRT-679 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLKEAINTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISTIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVIDSDANASIGMKKYFVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:734) PRT-680 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLPHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKHPEKQKIIFNNQELFDLRAAINTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTTLLTARHDLKNKGLNDISTIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:735) PRT-681 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVETRGDQTILLTARHDLKNKGLNDISTIIKQELTEGRALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVIDSDANASIGMKKYYVGINAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:736) PRT-682 MQITSVWTKGVTPLTPEQFRNNNEDVIHAPYLANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLKKHPEKQKIIFNNQELFDLKKAIDTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTSRHDLKNKGLNEISDIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:737) PRT-683 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYDITKAFNGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIIFNNQELFDLRKAINTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDHVFTRGDQTTLLTARHDLKNKTLNDISQIIKQELQEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGKNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:738) PRT-684 MQITSVWTKGVTPLTPEQFTNNNEDVIHAPYLANQGWYDITKTENGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKHPEKQKIIFNNQELFDLKKAIDTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQTKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLIAIYVTDSDANASIGMKKYFVGVNSHGKVAISAKKIEGENIGAQVLGLFTLSSGQ DIWQKLSLEHHHHHH(SEQIDNO:739) PRT-685 MQITSVWTKGVTPLTPEQFRNNNEDVIHAPYLPNQGWYDITKAFNGKDNLLCGAATAGNMLHWWFDQNKEEIE AYLKKYPEKQKIIFNNQELFDLRKAINTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDHVENRGDQTTLLTARHDLKNKILNDISTIIKQELSSGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGRNAHGHVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:740) PRT-686 MQITSVWTKGVTPLTPEQFTYNNEDVIHAPYIANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE NYLKKHPEKQKIIFNNQELFDLRKAINTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQTKDKRGGIFDHVFTRGDQSTLLTARHDLKNKTLNEISDIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYFVGVNSHGKVAISAKKIEDENIGAQVLGLFTLSSGQ DIWEQLSLEHHHHHH(SEQIDNO:741) PRT-687 MQITSVWTKGVTPLTPEQFRYNNEDVIHAPYKPHQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLKKYPEKQKIIFNNQKLFDLRKAINTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQTRDKRGGIFDHVFGRGDQTTLLTARHDLKNKTLNEISQIIKQELSEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANAKIGMKKYYVGKNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:742) PRT-688 MQITSVWTKGVTPLIMDDFTINNEDVIHAPYVANQGWYDITKTENGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKHPEKQKIIFNNQELFDLKEAINTKDSQTDSKLENYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYDTKDKRGGIFDHVFTRGDQSTLLTARHDLKNKTLKEISDIIKQELTEGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGVNSHGKVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:743) PRT-689 MQITSVWTKGVTPLTMDQFINNNEDVIHAPYKPGQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE NYLKKHPEKQKIIFNNQKLFDLRKAINTKDSQTNSALFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNREYQTKDKRGGIFDDVFGRGDQTTLLTARHDLKNGGLNDISQIIKQELSSGKALALSHTYANVS ISHVINLWGADFNEEGNLEAIYVTDSDANASIGMKKYYVGKNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:744) PRT-690 MQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLANQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDKDKRGGIFDAVENRGDQTTLLTARHDLKNKTLNDISTLIKQELSSGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVIDSDANSNIGMKKYKVGVNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:745) PRT-691 MQITTVWTKGVTPPTPEQFRYNNEDVIHAPYLPNQGWYDITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDRDKRGGIFDAVENRGDQTTLLTARHDLKNKTLNDISTLIKQELSSGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANASIGMKKYYVGVNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK DIWQKLSLEHHHHHH(SEQIDNO:746) PRT-692 MQITSVWTKGVTPPTPEQFRYNNEDVIHAPYLPNQGWYDITKTENGGDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINSKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDPDKRGGIFDDVFKEGDQTTLLTARHDLKNGTLNDISTLIKQELQSGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANQSIGMKKYKVGVNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:747) PRT-693 MQITSVWTKGVIPPTPEQFRYNNEDVIHAPYLPNQGWYDITKTENGGDNLLCGAATAGNMLHWWFDQNKTEIE AYLSKYPEKQKIIFNNQELFDLRAAINTKDSQTNSQLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNV FKTQSTDVNRPYQDRDKRGGIFDHVFGRGDQTTLLTARHDLKNGTLNDISTLIKQELQSGKALALSHTYANVS ISHVINLWGADFNAEGNLEAIYVTDSDANSSIGMKKYYVGVNAHGKVAISAKKIEGENIGAQVLGLFTLSSGK EIWQKLSLEHHHHHH(SEQIDNO:748) PRT-694 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKYPEKQKIIFNNQELFDVRAAINTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDKDKRGGIFDAVFNRGDQTTLLTARHDLKNKGLNEISDLIKQELSSGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANSNIGMKKYKVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLSLEHHHHHH(SEQIDNO:749) PRT-695 MTITTVWTKGVTPPTPEDFRYNNEDVLHAPYVPNQGWYDITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKYPEKQKIIFNNQELFDVRAAINTKDSQTNSKLFNYERDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDRDKRGGIFDAVENRGDQTTLLTARHDLKNKGLNEISDLIKQELSSGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANASIGMKKYYVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ DIWQKLSLEHHHHHH(SEQIDNO:750) PRT-696 MTITSVWTKGVTPPTPEDFRYNNEDVLHAPYVPNQGWYDITKTFDGGDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKYPEKQKIIFNNQELFDVRAAINSKDSQTNSKLENYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDPDKRGGIFDDVFKEGDQTTLLTARHDLKNGGLNEISDLIKQELQSGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANQSIGMKKYKVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ EIWQKLSLEHHHHHH(SEQIDNO:751) PRT-697 MTITSVWTKGVIPPTPEDFRYNNEDVLHAPYVPNQGWYDITKTFDGGDNLLCGAATAGNMLHWWFDQNKEEIE RYLKKYPEKQKIIFNNQELFDVRAAINTKDSQTNSKLFNYFRDKAFPNLSARQLGVMPDLVLDMFINGYYLNL GKTQSTDVNRPYQDRDKRGGIFDHVFGRGDQTTLLTARHDLKNGGLNEISDLIKQELQSGKALALSHTYANVR INHVINLWGADFDAEGNLIAIYVTDSDANSSIGMKKYYVGVNANGKVAISAKKIEGDNIGAQVLGLFTLSTGQ EIWQKLSLEHHHHHH(SEQIDNO:752) PRT-698 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1290) PRT-699 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIKNYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLINRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQTN (SEQIDNO:1291) PRT-700 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIKNYLKK YPEKQKINFGGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVETRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQIN (SEQIDNO:1292) PRT-701 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVTNSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1293) PRT-702 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVTDSNSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1294) PRT-703 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1295) PRT-704 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIKNYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQTN (SEQIDNO:1296) PRT-705 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIKNYLKK YPEKQKINFGGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQTN (SEQIDNO:1297) PRT-706 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTNSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1298) PRT-707 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLINRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTDSNSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1299) PRT-708 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLINRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVINSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1300) PRT-709 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRINHVINL WGADFDAEGNLEAIYVTDSNSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1301) PRT-710 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIKNYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQTN (SEQIDNO:1302) PRT-711 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIKNYLKK YPEKQKINFGGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWNQTN (SEQIDNO:1303) PRT-712 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVTNSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1304) PRT-713 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVTDSNSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1305) PRT-714 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVINSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1306) PRT-715 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVTDSNSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1307) PRT-716 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTNSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1308) PRT-717 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFNGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANGRINHVINL WGADFDAEGNLEAIYVTDSNSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1309) PRT-718 VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKLFNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKK YPEKQKINFKGEQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTDHGP TPVKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDLKEKTLKEISDLIKQELTEGKALGISHTYANVRIGHVINL WGADFDAEGNLEAIYVTDSDSNPSIGMKKYFVGVNSSGKVAISAKEIEEDNIGAQVLGLFTLSTGQDIWQQTN (SEQIDNO:1310) PRT-719 TITSVWTKGVTPPTPEDFRENNEDVLHAPYLANQGWYDITKAFDGKDNLLCGAATAGNMLHWWFDQNKEEIER YLKKHPEKQKIIFGNQELFDVKAAIDTKDSQTNSKLFDYFRDKAFPNLSARQLGVFPDLVLDMFINGYYLNGG KTQSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKGLNEISDLIKQELTEGKALALSHTYANVRI NHVINLWGADFDAEGNLEAIYVTDSDANPSIGMKKYFVGVNAHGKVAISAKKIEGDNIGAQVLGLFTLSTGQD QWQKLS(SEQIDNO:1333)

[0083] In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one amino acid sequence selected from SEQ ID NO: 55-1019, 1290-1310 and 1333. Additional support for specific embodiments of proteases having an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one amino acid sequence selected from SEQ ID NO: 55-1019, 1290-1310 and 1333 may be found in U.S. Provisional Application No. 63/478,789, filed Jan. 6, 2023, U.S. Provisional Application No. 63/483,142, filed Feb. 3, 2023, U.S. Provisional Application No. 63/493,142, filed Mar. 31, 2023, U.S. Provisional Application No. 63/506,539, filed Jun. 6, 2023, and/or U.S. Provisional Application No. 63/600,157, filed Nov. 17, 2023, each of which is hereby incorporated by reference in its entirety.

[0084] In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1290. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1291. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1292. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1293. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1294. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1295. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1296. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1297. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1298. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1299. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1300. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1301. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1302. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1303. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1304. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1305. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1306. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1307. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1308. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1309. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1310. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of SEQ ID NO: 1333.

[0085] In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of any one of SEQ ID NO: 56-752, and optionally does not comprise the methionine (M) residue at the N-terminus of any one of SEQ ID NO: 56-752. For example, the protease having an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of any one of SEQ ID NO: 56-752, and optionally not comprising the methionine (M) residue at the N-terminus of any one of SEQ ID NO: 56-752, comprises the amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of any one of SEQ ID NO: 56-752, wherein the amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to the amino acid sequence of any one of SEQ ID NO: 56-752 does not comprise the methionine (M) residue at the N-terminus.

[0086] In some embodiments, the protease has an amino acid sequence selected from SEQ ID NO: 55-1019, 1290-1310 and 1333. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 56. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 57. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 58. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 59. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 60. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 61. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 62. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 63. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 64. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 65. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 66. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 67. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 68. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 69. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 70. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 71. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 72. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 73. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 74. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 75. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 76. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 77. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 78. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 79. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 80. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 81. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 82. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 83. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 84. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 85. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 86. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 87. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 88. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 89. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 90. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 91. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 92. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 93. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 94. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 95. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 96. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 97. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 98. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 99. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 100. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 101. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 102. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 103. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 104. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 105. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 106. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 107. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 108. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 109. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 110. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 111. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 112. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 113. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 114. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 115. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 116. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 117. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 118. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 119. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 120. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 121. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 122. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 123. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 124. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 125. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 126. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 127. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 128. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 129. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 130. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 131. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 132. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 133. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 134. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 135. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 136. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 137. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 138. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 139. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 140. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 141. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 142. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 143. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 144. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 145. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 146. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 147. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 148. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 149. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 150. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 151. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 152. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 153. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 154. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 155. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 156. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 157. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 158. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 159. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 160. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 161. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 162. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 163. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 164. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 165. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 166. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 167. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 168. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 169. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 170. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 171. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 172. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 173. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 174. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 175. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 176. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 177. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 178. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 179. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 180. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 181. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 182. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 183. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 184. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 185. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 186. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 187. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 188. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 189. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 190. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 191. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 192. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 193. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 194. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 195. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 196. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 197. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 198. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 199. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 200. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 201. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 202. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 203. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 204. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 205. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 206. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 207. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 208. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 209. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 210. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 211. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 212. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 213. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 214. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 215. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 216. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 217. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 218. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 219. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 220. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 221. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 222. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 223. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 224. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 225. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 226. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 227. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 228. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 229. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 230. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 231. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 232. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 233. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 234. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 235. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 236. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 237. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 238. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 239. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 240. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 241. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 242. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 243. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 244. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 245. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 246. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 247. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 248. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 249. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 250. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 251. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 252. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 253. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 254. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 255. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 256. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 257. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 258. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 259. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 260. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 261. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 262. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 263. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 264. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 265. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 266. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 267. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 268. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 269. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 270. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 271. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 272. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 273. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 274. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 275. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 276. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 277. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 278. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 279. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 280. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 281. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 282. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 283. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 284. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 285. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 286. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 287. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 288. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 289. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 290. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 291. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 292. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 293. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 294. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 295. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 296. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 297. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 298. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 299. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 300. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 301. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 302. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 303. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 304. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 305. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 306. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 307. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 308. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 309. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 310. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 311. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 312. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 313. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 314. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 315. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 316. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 317. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 318. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 319. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 320. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 321. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 322. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 323. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 324. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 325. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 326. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 327. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 328. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 329. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 330. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 331. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 332. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 333. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 334. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 335. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 336. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 337. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 338. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 339. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 340. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 341. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 342. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 343. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 344. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 345. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 346. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 347. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 348. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 349. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 350. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 351. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 352. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 353. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 354. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 355. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 356. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 357. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 358. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 359. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 360. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 361. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 362. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 363. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 364. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 365. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 366. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 367. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 368. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 369. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 370. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 371. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 372. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 373. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 374. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 375. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 376. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 377. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 378. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 379. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 380. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 381. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 382. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 383. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 384. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 385. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 386. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 387. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 388. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 389. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 390. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 391. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 392. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 393. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 394. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 395. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 396. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 397. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 398. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 399. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 400. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 401. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 402. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 403. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 404. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 405. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 406. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 407. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 408. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 409. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 410. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 411. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 412. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 413. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 414. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 415. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 416. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 417. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 418. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 419. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 420. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 421. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 422. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 423. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 424. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 425. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 426. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 427. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 428. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 429. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 430. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 431. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 432. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 433. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 434. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 435. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 436. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 437. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 438. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 439. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 440. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 441. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 442. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 443. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 444. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 445. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 446. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 447. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 448. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 449. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 450. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 451. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 452. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 453. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 454. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 455. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 456. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 457. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 458. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 459. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 460. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 461. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 462. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 463. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 464. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 465. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 466. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 467. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 468. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 469. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 470. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 471. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 472. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 473. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 474. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 475. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 476. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 477. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 478. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 479. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 480. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 481. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 482. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 483. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 484. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 485. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 486. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 487. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 488. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 489. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 490. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 491. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 492. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 493. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 494. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 495. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 496. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 497. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 498. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 499. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 500. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 501. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 502. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 503. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 504. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 505. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 506. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 507. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 508. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 509. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 510. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 511. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 512. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 513. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 514. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 515. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 516. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 517. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 518. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 519. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 520. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 521. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 522. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 523. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 524. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 525. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 526. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 527. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 528. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 529. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 530. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 531. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 532. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 533. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 534. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 535. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 536. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 537. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 538. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 539. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 540. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 541. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 542. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 543. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 544. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 545. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 546. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 547. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 548. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 549. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 550. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 551. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 552. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 553. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 554. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 555. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 556. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 557. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 558. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 559. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 560. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 561. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 562. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 563. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 564. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 565. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 566. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 567. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 568. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 569. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 570. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 571. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 572. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 573. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 574. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 575. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 576. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 577. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 578. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 579. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 580. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 581. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 582. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 583. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 584. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 585. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 586. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 587. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 588. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 589. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 590. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 591. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 592. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 593. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 594. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 595. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 596. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 597. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 598. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 599. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 600. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 601. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 602. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 603. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 604. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 605. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 606. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 607. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 608. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 609. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 610. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 611. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 612. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 613. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 614. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 615. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 616. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 617. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 618. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 619. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 620. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 621. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 622. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 623. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 624. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 625. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 626. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 627. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 628. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 629. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 630. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 631. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 632. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 633. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 634. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 635. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 636. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 637. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 638. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 639. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 640. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 641. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 642. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 643. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 644. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 645. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 646. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 647. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 648. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 649. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 650. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 651. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 652. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 653. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 654. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 655. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 656. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 657. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 658. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 659. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 660. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 661. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 662. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 663. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 664. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 665. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 666. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 667. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 668. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 669. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 670. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 671. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 672. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 673. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 674. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 675. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 676. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 677. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 678. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 679. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 680. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 681. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 682. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 683. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 684. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 685. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 686. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 687. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 688. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 689. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 690. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 691. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 692. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 693. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 694. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 695. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 696. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 697. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 698. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 699. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 700. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 701. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 702. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 703. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 704. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 705. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 706. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 707. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 708. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 709. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 710. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 711. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 712. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 713. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 714. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 715. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 716. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 717. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 718. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 719. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 720. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 721. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 722. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 723. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 724. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 725. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 726. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 727. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 728. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 729. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 730. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 731. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 732. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 733. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 734. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 735. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 736. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 737. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 738. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 739. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 740. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 741. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 742. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 743. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 744. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 745. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 746. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 747. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 748. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 749. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 750. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 751. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 752. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 753. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 754. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 755. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 756. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 757. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 758. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 759. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 760. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 761. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 762. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 763. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 764. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 765. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 766. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 767. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 768. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 769. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 770. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 771. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 772. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 773. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 774. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 775. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 776. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 777. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 778. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 779. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 780. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 781. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 782. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 783. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 784. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 785. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 786. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 787. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 788. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 789. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 790. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 791. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 792. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 793. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 794. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 795. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 796. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 797. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 798. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 799. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 800. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 801. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 802. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 803. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 804. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 805. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 806. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 807. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 808. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 809. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 810. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 811. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 812. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 813. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 814. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 815. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 816. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 817. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 818. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 819. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 820. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 821. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 822. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 823. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 824. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 825. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 826. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 827. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 828. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 829. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 830. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 831. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 832. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 833. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 834. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 835. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 836. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 837. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 838. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 839. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 840. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 841. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 842. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 843. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 844. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 845. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 846. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 847. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 848. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 849. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 850. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 851. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 852. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 853. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 854. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 855. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 856. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 857. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 858. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 859. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 860. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 861. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 862. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 863. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 864. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 865. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 866. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 867. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 868. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 869. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 870. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 871. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 872. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 873. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 874. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 875. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 876. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 877. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 878. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 879. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 880. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 881. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 882. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 883. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 884. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 885. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 886. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 887. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 888. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 889. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 890. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 891. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 892. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 893. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 894. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 895. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 896. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 897. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 898. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 899. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 900. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 901. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 902. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 903. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 904. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 905. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 906. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 907. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 908. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 909. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 910. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 911. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 912. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 913. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 914. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 915. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 916. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 917. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 918. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 919. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 920. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 921. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 922. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 923. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 924. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 925. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 926. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 927. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 928. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 929. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 930. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 931. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 932. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 933. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 934. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 935. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 936. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 937. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 938. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 939. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 940. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 941. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 942. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 943. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 944. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 945. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 946. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 947. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 948. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 949. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 950. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 951. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 952. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 953. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 954. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 955. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 956. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 957. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 958. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 959. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 960. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 961. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 962. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 963. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 964. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 965. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 966. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 967. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 968. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 969. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 970. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 971. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 972. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 973. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 974. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 975. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 976. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 977. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 978. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 979. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 980. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 981. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 982. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 983. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 984. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 985. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 986. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 987. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 988. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 989. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 990. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 991. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 992. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 993. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 994. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 995. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 996. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 997. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 998. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 999. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1000. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1001. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1002. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1003. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1004. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1005. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1006. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1007. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1008. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1009. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1010. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1011. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1012. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1013. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1014. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1015. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1016. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1017. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1018. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1019. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1290. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1291. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1292. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1293. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1294. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1295. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1296. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1297. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1298. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1299. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1300. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1301. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1302. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1303. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1304. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1305. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1306. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1307. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1308. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1309. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1310. In some embodiments, the protease has an amino acid sequence of SEQ ID NO: 1333.

[0087] In some embodiments, the protease has an amino acid sequence of any one of SEQ ID NO: 56-752, and optionally does not comprise the methionine (M) residue at the N-terminus of any one of SEQ ID NO: 56-752. For example, the protease having an amino acid sequence of any one of SEQ ID NO: 56-752, and optionally not comprising the methionine (M) residue at the N-terminus of any one of SEQ ID NO: 56-752, comprises the amino acid sequence of any one of SEQ ID NO: 56-752, wherein the amino acid sequence of any one of SEQ ID NO: 56-752 does not comprise the methionine (M) residue at the N-terminus.

[0088] In some embodiments, the protease and polypeptides provided for herein comprise a leader sequence that is present at the N-terminus of the polypeptide. Without being bound to any particular theory, leader sequences can facilitate the expression of polypeptides in eukaryotic cells. Any suitable leader sequence can be utilized. For example, leader sequences comprising the sequence of METDTLLLWVLLLWVPGSTG (SEQ ID NO: 1357), or MGWSCIILFLVATATGVHS (SEQ ID NO: 1358) be used. These are non-limiting examples of leader sequences. The leader sequences are processed (removed) from the polypeptide as it is being translated and expressed in the cell leaving the polypeptides provided for herein. Thus, in some embodiments, when present in a pharmaceutical composition or as an isolated polypeptide, the polypeptides provided for herein do not comprise a leader sequence. In some embodiments, polypeptides provided for herein comprise an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one amino acid sequence selected from SEQ ID NO: 55-1019, 1290-1310 and 1333, and further comprises a leader amino acid sequence. In some embodiments, the protease has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one amino acid sequence selected from SEQ ID NO: 55-1019, 1290-1310 and 1333, and further comprises a leader amino acid sequence having an amino acid sequence of METDTLLLWVLLLWVPGSTG (SEQ ID NO: 1357), or MGWSCIILFLVATATGVHS (SEQ ID NO: 1358). In some embodiments, the leader amino acid sequence is N-terminal to the protease. In some embodiments, the leader amino acid sequence facilitates expression of the protease. In some embodiments, the leader amino acid sequence is processed and removed from the protease during expression ex vivo or in vivo.

[0089] In some embodiments, the protease comprises the polypeptide. In some embodiments, the polypeptide comprises a mutation at any position as compared to SEQ ID NO: 35. In some embodiments, the mutation is a substitution, a deletion, or an insertion. In some embodiments, the mutation is a substitution. Non-limiting examples of positions that may comprise mutations, as compared to SEQ ID NO: 35, are provided in Table 20 below.

[0090] In some embodiments, the polypeptide comprises a mutation at any position provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a set of mutations at any set of positions provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an amino acid sequence having a mutation at any position provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an amino acid sequence having a set of mutations at any set of positions provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 51%, at least 52%, at least 53%, at least 54%, at least 55%, at least 56%, at least 57%, at least 58%, at least 59%, at least 60%, at least 61%, at least 62%, at least 63%, at least 64%, at least 65%, at least 66%, at least 67%, at least 68%, at least 69%, at least 70%, at least 71%, at least 72%, at least 73%, at least 74%, at least 75%, at least 76%, at least 77%, at least 78%, at least 79%, at least 80%, at least 81%, at least 82%, at least 83%, at least 84%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the amino acid sequence comprises a mutation at any position, or any set of mutations at any set of positions, provided in Table 20, as compared to SEQ ID NO: 35.

TABLE-US-00009 TABLE 20 Non-limiting examples of positions that may comprise a mutation, or a set of mutations [as compared to SEQ ID NO: 35] 60 61 63 64 74 76 146 227 229 121 130 134 154 190 225 229 258 289 303 336 85 and 121 85 and 130 85 and 134 85 and 154 85 and 190 85 and 225 85 and 229 85 and 258 85 and 289 85 and 303 85 and 336 121 and 130 121 and 134 121 and 154 121 and 190 121 and 225 121 and 229 121 and 258 121 and 289 121 and 303 121 and 336 130 and 134 130 and 154 130 and 190 130 and 225 130 and 229 130 and 258 130 and 289 130 and 303 130 and 336 134 and 154 134 and 190 134 and 225 134 and 229 134 and 258 134 and 289 134 and 303 134 and 336 154 and 190 154 and 225 154 and 229 154 and 258 154 and 289 154 and 303 154 and 336 190 and 225 190 and 229 190 and 258 190 and 289 190 and 303 190 and 336 225 and 229 225 and 258 225 and 289 225 and 303 225 and 336 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 60 and 61 60 and 63 60 and 64 60 and 74 60 and 76 60 and 146 60 and 227 60 and 229 61 and 63 61 and 64 61 and 74 61 and 76 61 and 146 61 and 227 61 and 229 63 and 64 63 and 74 63 and 76 63 and 146 63 and 227 63 and 229 64 and 74 64 and 76 64 and 146 64 and 227 64 and 229 74 and 76 74 and 146 74 and 227 74 and 229 76 and 146 76 and 227 76 and 229 146 and 227 146 and 229 227 and 229 60, 61 and 63 60, 61 and 64 60, 61 and 74 60, 61 and 76 60, 61 and 146 60, 61 and 227 60, 61 and 229 60, 63 and 64 60, 63 and 74 60, 63 and 76 60, 63 and 146 60, 63 and 227 60, 63 and 229 60, 64 and 74 60, 64 and 76 60, 64 and 146 60, 64 and 227 60, 64 and 229 60, 74 and 76 60, 74 and 146 60, 74 and 227 60, 74 and 229 60, 76 and 146 60, 76 and 227 60, 76 and 229 60, 146 and 227 60, 146 and 229 60, 227 and 229 61, 63 and 64 61, 63 and 74 61, 63 and 76 61, 63 and 146 61, 63 and 227 61, 63 and 229 61, 64 and 74 61, 64 and 76 61, 64 and 146 61, 64 and 227 61, 64 and 229 61, 74 and 76 61, 74 and 146 61, 74 and 227 61, 74 and 229 61, 76 and 146 61, 76 and 227 61, 76 and 229 61, 146 and 227 61, 146 and 229 61, 227 and 229 63, 64 and 74 63, 64 and 76 63, 64 and 146 63, 64 and 227 63, 64 and 229 63, 74 and 76 63, 74 and 146 63, 74 and 227 63, 74 and 229 63, 76 and 146 63, 76 and 227 63, 76 and 229 63, 146 and 227 63, 146 and 229 63, 227 and 229 64, 74 and 76 64, 74 and 146 64, 74 and 227 64, 74 and 229 64, 76 and 146 64, 76 and 227 64, 76 and 229 64, 146 and 227 64, 146 and 229 64, 227 and 229 74, 76 and 146 74, 76 and 227 74, 76 and 229 74, 146 and 227 74, 146 and 229 74, 227 and 229 76, 146 and 227 76, 146 and 229 76, 227 and 229 146, 227 and 229 85, 121 and 134 85, 121 and 154 85, 121 and 190 85, 121 and 225 85, 121 and 229 85, 121 and 258 85, 121 and 289 85, 121 and 303 85, 121 and 336 85, 130 and 134 85, 130 and 154 85, 130 and 190 85, 130 and 225 85, 130 and 229 85, 130 and 258 85, 130 and 289 85, 130 and 303 85, 130 and 336 85, 134 and 154 85, 134 and 190 85, 134 and 225 85, 134 and 229 85, 134 and 258 85, 134 and 289 85, 134 and 303 85, 134 and 336 85, 154 and 190 85, 154 and 225 85, 154 and 229 85, 154 and 258 85, 154 and 289 85, 154 and 303 85, 154 and 336 85, 190 and 225 85, 190 and 229 85, 190 and 258 85, 190 and 289 85, 190 and 303 85, 190 and 336 85, 225 and 229 85, 225 and 258 85, 225 and 289 85, 225 and 303 85, 225 and 336 85, 229 and 258 85, 229 and 289 85, 229 and 303 85, 229 and 336 85, 258 and 289 85, 258 and 303 85, 258 and 336 85, 289 and 303 85, 289 and 336 85, 303 and 336 121, 130 and 134 121, 130 and 154 121, 130 and 190 121, 130 and 225 121, 130 and 229 121, 130 and 258 121, 130 and 289 121, 130 and 303 121, 130 and 336 121, 134 and 154 121, 134 and 190 121, 134 and 225 121, 134 and 229 121, 134 and 258 121, 134 and 289 121, 134 and 303 121, 134 and 336 121, 154 and 190 121, 154 and 225 121, 154 and 229 121, 154 and 258 121, 154 and 289 121, 154 and 303 121, 154 and 336 121, 190 and 225 121, 190 and 229 121, 190 and 258 121, 190 and 289 121, 190 and 303 121, 190 and 336 121, 225 and 229 121, 225 and 258 121, 225 and 289 121, 225 and 303 121, 225 and 336 121, 229 and 258 121, 229 and 289 121, 229 and 303 121, 229 and 336 121, 258 and 289 121, 258 and 303 121, 258 and 336 121, 289 and 303 121, 289 and 336 121, 303 and 336 130, 134 and 154 130, 134 and 190 130, 134 and 225 130, 134 and 229 130, 134 and 258 130, 134 and 289 130, 134 and 303 130, 134 and 336 130, 154 and 190 130, 154 and 225 130, 154 and 229 130, 154 and 258 130, 154 and 289 130, 154 and 303 130, 154 and 336 130, 190 and 225 130, 190 and 229 130, 190 and 258 130, 190 and 289 130, 190 and 303 130, 190 and 336 130, 225 and 229 130, 225 and 258 130, 225 and 289 130, 225 and 303 130, 225 and 336 130, 229 and 258 130, 229 and 289 130, 229 and 303 130, 229 and 336 130, 258 and 289 130, 258 and 303 130, 258 and 336 130, 289 and 303 130, 289 and 336 130, 303 and 336 134, 154 and 190 134, 154 and 225 134, 154 and 229 134, 154 and 258 134, 154 and 289 134, 154 and 303 134, 154 and 336 134, 190 and 225 134, 190, and 229 134, 190 and 258 134, 190 and 289 134, 190 and 303 134, 190 and 336 134, 225 and 229 134, 225 and 258 134, 225 and 289 134, 225 and 303 134, 225 and 336 134, 229 and 258 134, 229 and 289 134, 229 and 303 134, 229 and 336 134, 258 and 289 134, 258 and 303 134, 258 and 336 134, 289 and 303 134, 289 and 336 134, 303 and 336 154, 190 and 225 154, 190 and 229 154, 190 and 258 154, 190 and 289 154, 190 and 303 154, 190 and 336 154, 225 and 229 154, 225 and 258 154, 225 and 289 154, 225 and 303 154, 225 and 336 154, 229 and 258 154, 229 and 289 154, 229 and 303 154, 229 and 336 154, 258 and 289 154, 258 and 303 154, 258 and 336 154, 289 and 303 154, 289 and 336 154, 303 and 336 190, 225 and 229 190, 225 and 258 190, 225 and 289 190, 225 and 303 190, 225 and 336 190, 229 and 258 190, 229 and 289 190, 229 and 303 190, 229 and 336 190, 258 and 289 190, 258 and 303 190, 258 and 336 190, 289 and 303 190, 289 and 336 190, 303 and 336 225, 229 and 258 225, 229 and 289 225, 229 and 303 225, 229 and 336 225, 258 and 289 225, 258 and 303 225, 258 and 336 225, 289 and 303 225, 289 and 336 225, 303 and 336 229, 258 and 289 229, 258 and 303 229, 258 and 336 229, 289 and 303 229, 289 and 336 229, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 85, 121, 130 and 85, 121, 130 and 85, 121, 130 and 85, 121, 130 and 85, 121, 130 and 134 154 190 225 229 85, 121, 130 and 85, 121, 130 and 85, 121, 130 and 85, 121, 130 and 85, 121, 134 and 258 289 303 336 154 85, 121, 134 and 85, 121, 134 and 85, 121, 134 and 85, 121, 134 and 85, 121, 134 and 190 225 229 258 289 85, 121, 134 and 85, 121, 134 and 85, 121, 154 and 85, 121, 154 and 85, 121, 154 and 303 336 190 225 229 85, 121, 154 and 85, 121, 154 and 85, 121, 154 and 85, 121, 154 and 85, 121, 190 and 258 289 303 336 225 85, 121, 190 and 85, 121, 190 and 85, 121, 190 and 85, 121, 190 and 85, 121, 190 and 229 258 289 303 336 85, 121, 225 and 85, 121, 225 and 85, 121, 225 and 85, 121, 225 and 85, 121, 225 and 229 258 289 303 336 85, 121, 229 and 85, 121, 229 and 85, 121, 229 and 85, 121, 229 and 85, 121, 258 and 258 289 303 336 289 85, 121, 258 and 85, 121, 258 and 85, 121, 289 and 85, 121, 289 and 85, 121, 303 and 303 336 303 336 336 85, 130, 134 and 85, 130, 134 and 85, 130, 134 and 85, 130, 134 and 85, 130, 134 and 154 190 225 229 258 85, 130, 134 and 85, 130, 134 and 85, 130, 134 and 85, 130, 154 and 85, 130, 154 and 289 303 336 190 225 85, 130, 154 and 85, 130, 154 and 85, 130, 154 and 85, 130, 154 and 85, 130, 154 and 229 258 289 303 336 85, 130, 190 and 85, 130, 190 and 85, 130, 190 and 85, 130, 190 and 85, 130, 190 and 225 229 258 289 303 85, 130, 190 and 85, 130, 225 and 85, 130, 225 and 85, 130, 225 and 85, 130, 225 and 336 229 258 289 303 85, 130, 225 and 85, 130, 229 and 85, 130, 229 and 85, 130, 229 and 85, 130, 229 and 336 258 289 303 336 85, 130, 258 and 85, 130, 258 and 85, 130, 258 and 85, 130, 289 and 85, 130, 289 and 289 303 336 303 336 85, 130, 303 and 85, 134, 154 and 85, 134, 154 and 85, 134, 154 and 85, 134, 154 and 336 190 225 229 258 85, 134, 154 and 85, 134, 154 and 85, 134, 154 and 85, 134, 190 and 85, 134, 190 and 289 303 336 225 229 85, 134, 190 and 85, 134, 190 and 85, 134, 190 and 85, 134, 190 and 85, 134, 225 and 258 289 303 336 229 85, 134, 225 and 85, 134, 225 and 85, 134, 225 and 85, 134, 225 and 85, 134, 229 and 258 289 303 336 258 85, 134, 229 and 85, 134, 229 and 85, 134, 229 and 85, 134, 258 and 85, 134, 258 and 289 303 336 289 303 85, 134, 258 and 85, 134, 289 and 85, 134, 289 and 85, 134, 303 and 85, 154, 190 and 336 303 336 336 225 85, 154, 190 and 85, 154, 190 and 85, 154, 190 and 85, 154, 190 and 85, 154, 190 and 229 258 289 303 336 85, 154, 225 and 85, 154, 225 and 85, 154, 225 and 85, 154, 225 and 85, 154, 225 and 229 258 289 303 336 85, 154, 229 and 85, 154, 229 and 85, 154, 229 and 85, 154, 229 and 85, 154, 258 and 258 289 303 336 289 85, 154, 258 and 85, 154, 258 and 85, 154, 289 and 85, 154, 289 and 85, 154, 303 and 303 336 303 336 336 85, 190, 225 and 85, 190, 225 and 85, 190, 225 and 85, 190, 225 and 85, 190, 225 and 229 258 289 303 336 85, 190, 229 and 85, 190, 229 and 85, 190, 229 and 85, 190, 229 and 85, 190, 258 and 258 289 303 336 289 85, 190, 258 and 85, 190, 258 and 85, 190, 289 and 85, 190, 289 and 85, 190, 303 and 303 336 303 336 336 85, 225, 229 and 85, 225, 229 and 85, 225, 229 and 85, 225, 229 and 85, 225, 258 and 258 289 303 336 289 85, 225, 258 and 85, 225, 258 and 85, 225, 289 and 85, 225, 289 and 85, 225, 303 and 303 336 303 336 336 85, 229, 258 and 85, 229, 258 85, 229, 258 and 85, 229, 289 and 85, 229, 289 and 289 and 303 336 303 336 85, 229, 303 and 85, 258, 289 85, 258, 289 and 85, 258, 303 and 85, 289, 303 and 336 and 303 336 336 336 121, 130, 134 121, 130, 134 121, 130, 134 121, 130, 134 121, 130, 134 and 154 and 190 and 225 and 229 and 258 121, 130, 134 121, 130, 134 121, 130, 134 121, 130, 154 121, 130, 154 and 289 and 303 and 336 and 190 and 225 121, 130, 154 121, 130, 154 121, 130, 154 121, 130, 154 121, 130, 154 and 229 and 258 and 289 and 303 and 336 121, 130, 190 121, 130, 190 121, 130, 190 121, 130, 190 121, 130, 190 and 225 and 229 and 258 and 289 and 303 121, 130, 190 121, 130, 225 121, 130, 225 121, 130, 225 121, 130, 225 and 336 and 229 and 258 and 289 and 303 121, 130, 225 121, 130, 229 121, 130, 229 121, 130, 229 121, 130, 229 and 336 and 258 and 289 and 303 and 336 121, 130, 258 121, 130, 258 121, 130, 258 121, 130, 289 121, 130, 289 and 289 and 303 and 336 and 303 and 336 121, 130, 303 121, 134, 154 121, 134, 154 121, 134, 154 121, 134, 154 and 336 and 190 and 225 and 229 and 258 121, 134, 154 121, 134, 154 121, 134, 154 121, 134, 190 121, 134, 190 and 289 and 303 and 336 and 225 and 229 121, 134, 190 121, 134, 190 121, 134, 190 121, 134, 190 121, 134, 225 and 258 and 289 and 303 and 336 and 229 121, 134, 225 121, 134, 225 121, 134, 225 121, 134, 225 121, 134, 229 and 258 and 289 and 303 and 336 and 258 121, 134, 229 121, 134, 229 121, 134, 229 121, 134, 258 121, 134, 258 and 289 and 303 and 336 and 289 and 303 121, 134, 258 121, 134, 289 121, 134, 289 121, 134, 303 121, 154, 190 and 336 and 303 and 336 and 336 and 225 121, 154, 190 121, 154, 190 121, 154, 190 121, 154, 190 121, 154, 190 and 229 and 258 and 289 and 303 and 336 121, 154, 225 121, 154, 225 121, 154, 225 121, 154, 225 121, 154, 225 and 229 and 258 and 289 and 303 and 336 121, 154, 229 121, 154, 229 121, 154, 229 121, 154, 229 121, 154, 258 and 258 and 289 and 303 and 336 and 289 121, 154, 258 121, 154, 258 121, 154, 289 121, 154, 289 121, 154, 303 and 303 and 336 and 303 and 336 and 336 121, 190, 225 121, 190, 225 121, 190, 225 121, 190, 225 121, 190, 225 and 229 and 258 and 289 and 303 and 336 121, 190, 229 121, 190, 229 121, 190, 229 121, 190, 229 121, 190, 258 and 258 and 289 and 303 and 336 and 289 121, 190, 258 121, 190, 258 121, 190, 289 121, 190, 289 121, 190, 303 and 303 and 336 and 303 and 336 and 336 121, 225, 229 121, 225, 229 121, 225, 229 121, 225, 229 121, 225, 258 and 258 and 289 and 303 and 336 and 289 121, 225, 258 121, 225, 258 121, 225, 289 121, 225, 289 121, 225, 303 and 303 and 336 and 303 and 336 and 336 121, 229, 258 121, 229, 258 121, 229, 258 121, 229, 289 121, 229, 289 and 289 and 303 and 336 and 303 and 336 121, 229, 303 121, 258, 289 121, 258, 289 121, 258, 303 121, 289, 303 and 336 and 303 and 336 and 336 and 336 130, 134, 154 130, 134, 154 130, 134, 154 130, 134, 154 130, 134, 154 and 190 and 225 and 229 and 258 and 289 130, 134, 154 130, 134, 154 130, 134, 190 130, 134, 190 130, 134, 190 and 303 and 336 and 225 and 229 and 258 130, 134, 190 130, 134, 190 130, 134, 190 130, 134, 225 130, 134, 225 and 289 and 303 and 336 and 229 and 258 130, 134, 225 130, 134, 225 130, 134, 225 130, 134, 229 130, 134, 229 and 289 and 303 and 336 and 258 and 289 130, 134, 229 130, 134, 229 130, 134, 258 130, 134, 258 130, 134, 258 and 303 and 336 and 289 and 303 and 336 130, 134, 289 130, 134, 289 130, 134, 303 130, 154, 190 130, 154, 190 and 303 and 336 and 336 and 225 and 229 130, 154, 190 130, 154, 190 130, 154, 190 130, 154, 190 130, 154, 225 and 258 and 289 and 303 and 336 and 229 130, 154, 225 130, 154, 225 130, 154, 225 130, 154, 225 130, 154, 229 and 258 and 289 and 303 and 336 and 258 130, 154, 229 130, 154, 229 130, 154, 229 130, 154, 258 130, 154, 258 and 289 and 303 and 336 and 289 and 303 130, 154, 258 130, 154, 289 130, 154, 289 130, 154, 303 130, 190, 225 and 336 and 303 and 336 and 336 and 229 130, 190, 225 130, 190, 225 130, 190, 225 130, 190, 225 130, 190, 229 and 258 and 289 and 303 and 336 and 258 130, 190, 229 130, 190, 229 130, 190, 229 130, 190, 258 130, 190, 258 and 289 and 303 and 336 and 289 and 303 130, 190, 258 130, 190, 289 130, 190, 289 130, 190, 303 130, 225, 229 and 336 and 303 and 336 and 336 and 258 130, 225, 229 130, 225, 229 130, 225, 229 130, 225, 258 130, 225, 258 and 289 and 303 and 336 and 289 and 303 130, 225, 258 130, 225, 289 130, 225, 289 130, 225, 303 130, 229, 258 and 336 and 303 and 336 and 336 and 289 130, 229, 258 130, 229, 258 130, 229, 289 130, 229, 289 130, 229, 303 and 303 and 336 and 303 and 336 and 336 130, 258, 289 130, 258, 289 130, 258, 303 130, 289, 303 134, 154, 190 and 303 and 336 and 336 and 336 and 225 134, 154, 190 134, 154, 190 134, 154, 190 134, 154, 190 134, 154, 190 and 229 and 258 and 289 and 303 and 336 134, 154, 225 134, 154, 225 134, 154, 225 134, 154, 225 134, 154, 225 and 229 and 258 and 289 and 303 and 336 134, 154, 229 134, 154, 229 134, 154, 229 134, 154, 229 134, 154, 258 and 258 and 289 and 303 and 336 and 289 134, 154, 258 134, 154, 258 134, 154, 289 134, 154, 289 134, 154, 303 and 303 and 336 and 303 and 336 and 336 134, 190, 225 134, 190, 225 134, 190, 225 134, 190, 225 134, 190, 225 and 229 and 258 and 289 and 303 and 336 134, 190, 229 134, 190, 229 134, 190, 229 134, 190, 229 134, 190, 258 and 258 and 289 and 303 and 336 and 289 134, 190, 258 134, 190, 258 134, 190, 289 134, 190, 289 134, 190, 303 and 303 and 336 and 303 and 336 and 336 134, 225, 229 134, 225, 229 134, 225, 229 134, 225, 229 134, 225, 258 and 258 and 289 and 303 and 336 and 289 134, 225, 258 134, 225, 258 134, 225, 289 134, 225, 289 134, 225, 303 and 303 and 336 and 303 and 336 and 336 134, 229, 258 134, 229, 258 134, 229, 258 134, 229, 289 134, 229, 289 and 289 and 303 and 336 and 303 and 336 134, 229, 303 134, 258, 289 134, 258, 289 134, 258, 303 134, 289, 303 and 336 and 303 and 336 and 336 and 336 154, 190, 225 154, 190, 225 154, 190, 225 154, 190, 225 154, 190, 225 and 229 and 258 and 289 and 303 and 336 154, 190, 229 154, 190, 229 154, 190, 229 154, 190, 229 154, 190, 258 and 258 and 289 and 303 and 336 and 289 154, 190, 258 154, 190, 258 154, 190, 289 154, 190, 289 154, 190, 303 and 303 and 336 and 303 and 336 and 336 154, 225, 229 154, 225, 229 154, 225, 229 154, 225, 229 154, 225, 258 and 258 and 289 and 303 and 336 and 289 154, 225, 258 154, 225, 258 154, 225, 289 154, 225, 289 154, 225, 303 and 303 and 336 and 303 and 336 and 336 154, 229, 258 154, 229, 258 154, 229, 258 154, 229, 289 154, 229, 289 and 289 and 303 and 336 and 303 and 336 154, 229, 303 154, 258, 289 154, 258, 289 154, 258, 303 154, 289, 303 and 336 and 303 and 336 and 336 and 336 190, 225, 229 190, 225, 229 190, 225, 229 190, 225, 229 190, 225, 258 and 258 and 289 and 303 and 336 and 289 190, 225, 258 190, 225, 258 190, 225, 289 190, 225, 289 190, 225, 303 and 303 and 336 and 303 and 336 and 336 190, 229, 258 190, 229, 258 190, 229, 258 190, 229, 289 190, 229, 289 and 289 and 303 and 336 and 303 and 336 190, 229, 303 190, 258, 289 190, 258, 289 190, 258, 303 190, 289, 303 and 336 and 303 and 336 and 336 and 336 225, 229, 258 225, 229, 258 225, 229, 258 225, 229, 289 225, 229, 289 and 289 and 303 and 336 and 303 and 336 225, 229, 303 225, 258, 289 225, 258, 289 225, 258, 303 225, 289, 303 and 336 and 303 and 336 and 336 and 336 229, 258, 289 229, 258, 289 229, 258, 303 229, 289, 303 258, 289, 303 and 303 and 336 and 336 and 336 and 336 60, 61, 63 and 60, 61, 63 and 60, 61, 63 and 60, 61, 63 and 60, 61, 63 and 64 74 76 146 227 60, 61, 63 and 60, 61, 64 and 60, 61, 64 and 60, 61, 64 and 60, 61, 64 and 229 74 76 146 227 60, 61, 64 and 60, 61, 74 and 60, 61, 74 and 60, 61, 74 and 60, 61, 74 and 229 76 146 227 229 60, 61, 76 and 60, 61, 76 and 60, 61, 76 and 60, 61, 146 60, 61, 146 146 227 229 and 227 and 229 60, 61, 227 and 60, 63, 64 and 60, 63, 64 and 60, 63, 64 and 60, 63, 64 and 229 74 76 146 227 60, 63, 64 and 60, 63, 74 and 60, 63, 74 and 60, 63, 74 and 60, 63, 74 and 229 76 146 227 229 60, 63, 76 and 60, 63, 76 and 60, 63, 76 and 60, 63, 146 60, 63, 146 146 227 229 and 227 and 229 60, 63, 227 and 60, 64, 74 and 60, 64, 74 and 60, 64, 74 and 60, 64, 74 and 229 76 146 227 229 60, 64, 76 and 60, 64, 76 and 60, 64, 76 and 60, 64, 146 60, 64, 146 146 227 229 and 227 and 229 60, 64, 227 and 60, 74, 76 and 60, 74, 76 and 60, 74, 76 and 60, 74, 146 and 229 146 227 229 227 60, 74, 146 and 60, 74, 227 60, 76, 146 60, 76, 146 60, 76, 227 and 229 and 229 and 227 and 229 229 60, 146, 227 61, 63, 64 and 61, 63, 64 and 61, 63, 64 and 61, 63, 64 and and 229 74 76 146 227 61, 63, 64 and 61, 63, 74 and 61, 63, 74 and 61, 63, 74 and 61, 63, 74 and 229 76 146 227 229 61, 63, 76 and 61, 63, 76 and 61, 63, 76 and 61, 63, 146 61, 63, 146 and 146 227 229 and 227 229 61, 63, 227 and 61, 64, 74 and 61, 64, 74 and 61, 64, 74 and 61, 64, 74 and 229 76 146 227 229 61, 64, 76 and 61, 64, 76 and 61, 64, 76 and 61, 64, 146 61, 64, 146 and 146 227 229 and 227 229 61, 64, 227 and 61, 74, 76 and 61, 74, 76 and 61, 74, 76 61, 74, 146 and 229 146 227 and 229 227 61, 74, 146 and 61, 74, 227 61, 76, 146 61, 76, 146 61, 76, 227 and 229 and 229 and 227 and 229 229 61, 146, 227 63, 64, 74 and 63, 64, 74 63, 64, 74 63, 64, 74 and and 229 76 and 146 and 227 229 63, 64, 76 and 63, 64, 76 and 63, 64, 76 63, 64, 146 63, 64, 146 and 146 227 and 229 and 227 229 63, 64, 227 and 63, 74, 76 and 63, 74, 76 63, 74, 76 63, 74, 146 and 229 146 and 227 and 229 227 63, 74, 146 and 63, 74, 227 63, 76, 146 63, 76, 146 63, 76, 227 and 229 and 229 and 227 and 229 229 63, 146, 227 64, 74, 76 and 64, 74, 76 64, 74, 76 64, 74, 146 and and 229 146 and 227 and 229 227 64, 74, 146 and 64, 74, 227 64, 76, 146 64, 76, 146 64, 76, 227 and 229 and 229 and 227 and 229 229 64, 146, 227 74, 76, 146 and 74, 76, 146 74, 76, 227 74, 146, 227 and and 229 227 and 229 and 229 229 76, 146, 227 60, 61, 63, 64 60, 61, 63, 64 60, 61, 63, 60, 61, 63, 64 and 229 and 74 and 76 64 and 146 and 227 60, 61, 63, 64 60, 61, 63, 74 60, 61, 63, 74 60, 61, 63, 60, 61, 63, 74 and 229 and 76 and 146 74 and 227 and 229 60, 61, 63, 76 60, 61, 63, 76 60, 61, 63, 76 60, 61, 63, 60, 61, 63, 146 and 146 and 227 and 229 146 and 227 and 229 60, 61, 63, 227 60, 61, 64, 74 60, 61, 64, 74 60, 61, 64, 74 60, 61, 64, 74 and 229 and 76 and 146 and 227 and 229 60, 61, 64, 76 60, 61, 64, 76 60, 61, 64, 76 60, 61, 64, 146 60, 61, 64, 146 and 146 and 227 and 229 and 227 and 229 60, 61, 64, 227 60, 61, 74, 76 60, 61, 74, 76 60, 61, 74, 76 60, 61, 74, 146 and 229 and 146 and 227 and 229 and 227 60, 61, 74, 146 60, 61, 74, 227 60, 61, 76, 146 60, 61, 76, 146 60, 61, 76, 227 and 229 and 229 and 227 and 229 and 229 60, 61, 146, 227 60, 63, 64, 74 60, 63, 64, 74 60, 63, 64, 74 60, 63, 64, 74 and 229 and 76 and 146 and 227 and 229 60, 63, 64, 76 60, 63, 64, 76 60, 63, 64, 76 60, 63, 64, 146 60, 63, 64, 146 and 146 and 227 and 229 and 227 and 229 60, 63, 64, 227 60, 63, 74, 76 60, 63, 74, 76 60, 63, 74, 76 60, 63, 74, 146 and 229 and 146 and 227 and 229 and 227 60, 63, 74, 146 60, 63, 74, 227 60, 63, 76, 146 60, 63, 76, 146 60, 63, 76, 227 and 229 and 229 and 227 and 229 and 229 60, 63, 146, 227 60, 64, 74, 76 60, 64, 74, 76 60, 64, 74, 76 60, 64, 74, 146 and 229 and 146 and 227 and 229 and 227 60, 64, 74, 146 60, 64, 74, 227 60, 64, 76, 146 60, 64, 76, 146 60, 64, 76, 227 and 229 and 229 and 227 and 229 and 229 60, 64, 146, 227 60, 74, 76, 146 60, 74, 76, 146 60, 74, 76, 227 60, 74, 146, 227 and 229 and 227 and 229 and 229 and 229 60, 76, 146, 227 61, 63, 64, 74 61, 63, 64, 74 61, 63, 64, 74 61, 63, 64, 74 and 229 and 76 and 146 and 227 and 229 61, 63, 64, 76 61, 63, 64, 76 61, 63, 64, 76 61, 63, 64, 146 61, 63, 64, 146 and 146 and 227 and 229 and 227 and 229 61, 63, 64, 227 61, 63, 74, 76 61, 63, 74, 76 61, 63, 74, 76 61, 63, 74, 146 and 229 and 146 and 227 and 229 and 227 61, 63, 74, 146 61, 63, 74, 227 61, 63, 76, 146 61, 63, 76, 146 61, 63, 76, 227 and 229 and 229 and 227 and 229 and 229 61, 63, 146, 227 61, 64, 74, 76 61, 64, 74, 76 61, 64, 74, 76 61, 64, 74, 146 and 229 and 146 and 227 and 229 and 227 61, 64, 74, 146 61, 64, 74, 227 61, 64, 76, 146 61, 64, 76, 146 61, 64, 76, 227 and 229 and 229 and 227 and 229 and 229 61, 64, 146, 227 61, 74, 76, 146 61, 74, 76, 146 61, 74, 76, 227 61, 74, 146, 227 and 229 and 227 and 229 and 229 and 229 61, 76, 146, 227 63, 64, 74, 76 63, 64, 74, 76 63, 64, 74, 76 63, 64, 74, 146 and 229 and 146 and 227 and 229 and 227 63, 64, 74, 146 63, 64, 74, 227 63, 64, 76, 146 63, 64, 76, 146 63, 64, 76, 227 and 229 and 229 and 227 and 229 and 229 63, 64, 146, 227 63, 74, 76, 146 63, 74, 76, 146 63, 74, 76, 227 63, 74, 146, 227 and 229 and 227 and 229 and 229 and 229 63, 76, 146, 227 64, 74, 76, 146 64, 74, 76, 146 64, 74, 76, 227 64, 74, 146, 227 and 229 and 227 and 229 and 229 and 229 64, 76, 146, 227 74, 76, 146, 227 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, and 229 and 229 74 and 76 74 and 146 74 and 227 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 74 and 229 76 and 146 76 and 227 76 and 229 146 and 227 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 74, 60, 61, 63, 74, 60, 61, 63, 74, 146 and 229 227 and 229 76 and 146 76 and 227 76 and 229 60, 61, 63, 74, 60, 61, 63, 74, 60, 61, 63, 74, 60, 61, 63, 76, 60, 61, 63, 76, 146 and 227 146 and 229 227 and 229 146 and 227 146 and 229 60, 61, 63, 76, 60, 61, 63, 146, 60, 61, 64, 74, 60, 61, 64, 74, 60, 61, 64, 74, 227 and 229 227 and 229 76 and 146 76 and 227 76 and 229 60, 61, 64, 74, 60, 61, 64, 74, 60, 61, 64, 74, 60, 61, 64, 76, 60, 61, 64, 76, 146 and 227 146 and 229 227 and 229 146 and 227 146 and 229 60, 61, 64, 76, 60, 61, 64, 146, 60, 61, 74, 76, 60, 61, 74, 76, 60, 61, 74, 76, 227 and 229 227 and 229 146 and 227 146 and 229 227 and 229 60, 61, 74, 146, 60, 61, 76, 146, 60, 63, 64, 74, 60, 63, 64, 74, 60, 63, 64, 74, 227 and 229 227 and 229 76 and 146 76 and 227 76 and 229 60, 63, 64, 74, 60, 63, 64, 74, 60, 63, 64, 74, 60, 63, 64, 76, 60, 63, 64, 76, 146 and 227 146 and 229 227 and 229 146 and 227 146 and 229 60, 63, 64, 76, 60, 63, 64, 146, 60, 63, 74, 76, 60, 63, 74, 76, 60, 63, 74, 76, 227 and 229 227 and 229 146 and 227 146 and 229 227 and 229 60, 63, 74, 146, 60, 63, 76, 146, 60, 64, 74, 76, 60, 64, 74, 76, 60, 64, 74, 76, 227 and 229 227 and 229 146 and 227 146 and 229 227 and 229 60, 64, 74, 146, 60, 64, 76, 146, 60, 74, 76, 146, 61, 63, 64, 74, 61, 63, 64, 74, 227 and 229 227 and 229 227 and 229 76 and 146 76 and 227 61, 63, 64, 74, 61, 63, 64, 74, 61, 63, 64, 74, 61, 63, 64, 74, 61, 63, 64, 76, 76 and 229 146 and 227 146 and 229 227 and 229 146 and 227 61, 63, 64, 76, 61, 63, 64, 76, 61, 63, 64, 146, 61, 63, 74, 76, 61, 63, 74, 76, 146 and 229 227 and 229 227 and 229 146 and 227 146 and 229 61, 63, 74, 76, 61, 63, 74, 146, 61, 63, 76, 146, 61, 64, 74, 76, 61, 64, 74, 76, 227 and 229 227 and229 227 and 229 146 and 227 146 and 229 61, 64, 74, 76, 61, 64, 74, 146, 61, 64, 76, 146, 61, 74, 76, 146, 63, 64, 74, 76, 227 and 229 227 and229 227 and 229 227 and 229 146 and 227 63, 64, 74, 76, 63, 64, 74, 76, 63, 64, 74, 146, 63, 64, 76, 146, 63, 74, 76, 146, 146 and 229 227 and 229 227 and 229 227 and 229 227 and 229 64, 74, 76, 146, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 227 and 229 74, 76 and 146 74, 76 and 227 74, 76 and 229 74, 146 and 227 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 74, 146 and 229 74, 227 and 229 76, 146 and 227 76, 146 and 229 76, 227 and 229 60, 61, 63, 64, 60, 61, 63, 74, 60, 61, 63, 74, 60, 61, 63, 74, 60, 61, 63, 74, 146, 227 and 229 76, 146 and 227 76, 146 and 229 76, 227 and 229 146, 227 and 229 60, 61, 63, 76, 60, 61, 64, 74, 60, 61, 64, 74, 60, 61, 64, 74, 60, 61, 64, 74, 146, 227 and 229 76, 146 and 227 76, 146 and 229 76, 227 and 229 146, 227 and 229 60, 61, 64, 76, 60, 61, 74, 76, 60, 63, 64, 74, 60, 63, 64, 74, 60, 63, 64, 74, 146, 227 and 229 146, 227 and 229 76, 146 and 227 76, 146 and 229 76, 227 and 229 60, 63, 64, 74, 60, 63, 64, 76, 60, 63, 74, 76, 60, 64, 74, 76, 61, 63, 64, 74, 146, 227 and 229 146, 227 and 229 146, 227 and 229 146, 227 and 229 76, 146 and 227 61, 63, 64, 74, 61, 63, 64, 74, 61, 63, 64, 74, 61, 63, 64, 76, 61, 63, 74, 76, 76, 146 and 229 76, 227 and 229 146, 227 and 229 146, 227 and 229 146, 227 and 229 61, 64, 74, 76, 63, 64, 74, 76, 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 64, 146, 227 and 229 146, 227 and 229 74, 76, 146 and 227 74, 76, 146 and 229 74, 76, 227 and 229 60, 61, 63, 64, 60, 61, 63, 64, 60, 61, 63, 74, 60, 61, 64, 74, 60, 63, 64, 74, 74, 146, 227 and 229 76, 146, 227 and 229 76, 146, 227 and 229 76, 146, 227 and 229 76, 146, 227 and 229 61, 63, 64, 74, 60, 61, 63, 64, 85, 121 and 130 76, 146, 227 and 229 74, 76, 146, 227 and 229 85, 121, 130, 134 85, 121, 130, 134 85, 121, 130, 134 85, 121, 130, 134 85, 121, 130, 134 and 154 and 190 and 225 and 229 and 258 85, 121, 130, 134 85, 121, 130, 134 85, 121, 130, 134 85, 121, 130, 154 85, 121, 130, 154 and 289 and 303 and 336 and 190 and 225 85, 121, 130, 154 85, 121, 130, 154 85, 121, 130, 154 85, 121, 130, 154 85, 121, 130, 154 and 229 and 258 and 289 and 303 and 336 85, 121, 130, 190 85, 121, 130, 190 85, 121, 130, 190 85, 121, 130, 190 85, 121, 130, 190 and 225 and 229 and 258 and 289 and 303 85, 121, 130, 190 85, 121, 130, 225 85, 121, 130, 225 85, 121, 130, 225 85, 121, 130, 225 and 336 and 229 and 258 and 289 and 303 85, 121, 130, 225 85, 121, 130, 229 85, 121, 130, 229 85, 121, 130, 229 85, 121, 130, 229 and 336 and 258 and 289 and 303 and 336 85, 121, 130, 258 85, 121, 130, 258 85, 121, 130, 258 85, 121, 130, 289 85, 121, 130, 289 and 289 and 303 and 336 and 303 and 336 85, 121, 130, 303 85, 121, 134, 154 85, 121, 134, 154 85, 121, 134, 154 85, 121, 134, 154 and 336 and 190 and 225 and 229 and 258 85, 121, 134, 154 85, 121, 134, 154 85, 121, 134, 154 85, 121, 134, 190 85, 121, 134, 190 and 289 and 303 and 336 and 225 and 229 85, 121, 134, 190 85, 121, 134, 190 85, 121, 134, 190 85, 121, 134, 190 85, 121, 134, 225 and 258 and 289 and 303 and 336 and 229 85, 121, 134, 225 85, 121, 134, 225 85, 121, 134, 225 85, 121, 134, 225 85, 121, 134, 229 and 258 and 289 and 303 and 336 and 258 85, 121, 134, 229 85, 121, 134, 229 85, 121, 134, 229 85, 121, 134, 258 85, 121, 134, 258 and 289 and 303 and 336 and 289 and 303 85, 121, 134, 258 85, 121, 134, 289 85, 121, 134, 289 85, 121, 134, 303 85, 121, 154, 190 and 336 and 303 and 336 and 336 and 225 85, 121, 154, 190 85, 121, 154, 190 85, 121, 154, 190 85, 121, 154, 190 85, 121, 154, 190 and 229 and 258 and 289 and 303 and 336 85, 121, 154, 225 85, 121, 154, 225 85, 121, 154, 225 85, 121, 154, 225 85, 121, 154, 225 and 229 and 258 and 289 and 303 and 336 85, 121, 154, 229 85, 121, 154, 229 85, 121, 154, 229 85, 121, 154, 229 85, 121, 154, 258 and 258 and 289 and 303 and 336 and 289 85, 121, 154, 258 85, 121, 154, 258 85, 121, 154, 289 85, 121, 154, 289 85, 121, 154, 303 and 303 and 336 and 303 and 336 and 336 85, 121, 190, 225 85, 121, 190, 225 85, 121, 190, 225 85, 121, 190, 225 85, 121, 190, 225 and 229 and 258 and 289 and 303 and 336 85, 121, 190, 229 85, 121, 190, 229 85, 121, 190, 229 85, 121, 190, 229 85, 121, 190, 258 and 258 and 289 and 303 and 336 and 289 85, 121, 190, 258 85, 121, 190, 258 85, 121, 190, 289 85, 121, 190, 289 85, 121, 190, 303 and 303 and 336 and 303 and 336 and 336 85, 121, 225, 229 85, 121, 225, 229 85, 121, 225, 229 85, 121, 225, 229 85, 121, 225, 258 and 258 and 289 and 303 and 336 and 289 85, 121, 225, 258 85, 121, 225, 258 85, 121, 225, 289 85, 121, 225, 289 85, 121, 225, 303 and 303 and 336 and 303 and 336 and 336 85, 121, 229, 258 85, 121, 229, 258 85, 121, 229, 258 85, 121, 229, 289 85, 121, 229, 289 and 289 and 303 and 336 and 303 and 336 85, 121, 229, 303 85, 121, 258, 289 85, 121, 258, 289 85, 121, 258, 303 85, 121, 289, 303 and 336 and 303 and 336 and 336 and 336 85, 130, 134, 154 85, 130, 134, 154 85, 130, 134, 154 85, 130, 134, 154 85, 130, 134, 154 and 190 and 225 and 229 and 258 and 289 85, 130, 134, 154 85, 130, 134, 154 85, 130, 134, 190 85, 130, 134, 190 85, 130, 134, 190 and 303 and 336 and 225 and 229 and 258 85, 130, 134, 190 85, 130, 134, 190 85, 130, 134, 190 85, 130, 134, 225 85, 130, 134, 225 and 289 and 303 and 336 and 229 and 258 85, 130, 134, 225 85, 130, 134, 225 85, 130, 134, 225 85, 130, 134, 229 85, 130, 134, 229 and 289 and 303 and 336 and 258 and 289 85, 130, 134, 229 85, 130, 134, 229 85, 130, 134, 258 85, 130, 134, 258 85, 130, 134, 258 and 303 and 336 and 289 and 303 and 336 85, 130, 134, 289 85, 130, 134, 289 85, 130, 134, 303 85, 130, 154, 190 85, 130, 154, 190 and 303 and 336 and 336 and 225 and 229 85, 130, 154, 190 85, 130, 154, 190 85, 130, 154, 190 85, 130, 154, 190 85, 130, 154, 225 and 258 and 289 and 303 and 336 and 229 85, 130, 154, 225 85, 130, 154, 225 85, 130, 154, 225 85, 130, 154, 225 85, 130, 154, 229 and 258 and 289 and 303 and 336 and 258 85, 130, 154, 229 85, 130, 154, 229 85, 130, 154, 229 85, 130, 154, 258 85, 130, 154, 258 and 289 and 303 and 336 and 289 and 303 85, 130, 154, 258 85, 130, 154, 289 85, 130, 154, 289 85, 130, 154, 303 85, 130, 190, 225 and 336 and 303 and 336 and 336 and 229 85, 130, 190, 225 85, 130, 190, 225 85, 130, 190, 225 85, 130, 190, 225 85, 130, 190, 229 and 258 and 289 and 303 and 336 and 258 85, 130, 190, 229 85, 130, 190, 229 85, 130, 190, 229 85, 130, 190, 258 85, 130, 190, 258 and 289 and 303 and 336 and 289 and 303 85, 130, 190, 258 85, 130, 190, 289 85, 130, 190, 289 85, 130, 190, 303 85, 130, 225, 229 and 336 and 303 and 336 and 336 and 258 85, 130, 225, 229 85, 130, 225, 229 85, 130, 225, 229 85, 130, 225, 258 85, 130, 225, 258 and 289 and 303 and 336 and 289 and 303 85, 130, 225, 258 85, 130, 225, 289 85, 130, 225, 289 85, 130, 225, 303 85, 130, 229, 258 and 336 and 303 and 336 and 336 and 289 85, 130, 229, 258 85, 130, 229, 258 85, 130, 229, 289 85, 130, 229, 289 85, 130, 229, 303 and 303 and 336 and 303 and 336 and 336 85, 130, 258, 289 85, 130, 258, 289 85, 130, 258, 303 85, 130, 289, 303 85, 134, 154, 190 and 303 and 336 and 336 and 336 and 225 85, 134, 154, 190 85, 134, 154, 190 85, 134, 154, 190 85, 134, 154, 190 85, 134, 154, 190 and 229 and 258 and 289 and 303 and 336 85, 134, 154, 225 85, 134, 154, 225 85, 134, 154, 225 85, 134, 154, 225 85, 134, 154, 225 and 229 and 258 and 289 and 303 and 336 85, 134, 154, 229 85, 134, 154, 229 85, 134, 154, 229 85, 134, 154, 229 85, 134, 154, 258 and 258 and 289 and 303 and 336 and 289 85, 134, 154, 258 85, 134, 154, 258 85, 134, 154, 289 85, 134, 154, 289 85, 134, 154, 303 and 303 and 336 and 303 and 336 and 336 85, 134, 190, 225 85, 134, 190, 225 85, 134, 190, 225 85, 134, 190, 225 85, 134, 190, 225 and 229 and 258 and 289 and 303 and 336 85, 134, 190, 229 85, 134, 190, 229 85, 134, 190, 229 85, 134, 190, 229 85, 134, 190, 258 and 258 and 289 and 303 and 336 and 289 85, 134, 190, 258 85, 134, 190, 258 85, 134, 190, 289 85, 134, 190, 289 85, 134, 190, 303 and 303 and 336 and 303 and 336 and 336 85, 134, 225, 229 85, 134, 225, 229 85, 134, 225, 229 85, 134, 225, 229 85, 134, 225, 258 and 258 and 289 and 303 and 336 and 289 85, 134, 225, 258 85, 134, 225, 258 85, 134, 225, 289 85, 134, 225, 289 85, 134, 225, 303 and 303 and 336 and 303 and 336 and 336 85, 134, 229, 258 85, 134, 229, 258 85, 134, 229, 258 85, 134, 229, 289 85, 134, 229, 289 and 289 and 303 and 336 and 303 and 336 85, 134, 229, 303 85, 134, 258, 289 85, 134, 258, 289 85, 134, 258, 303 85, 134, 289, 303 and 336 and 303 and 336 and 336 and 336 85, 154, 190, 225 85, 154, 190, 225 85, 154, 190, 225 85, 154, 190, 225 85, 154, 190, 225 and 229 and 258 and 289 and 303 and 336 85, 154, 190, 229 85, 154, 190, 229 85, 154, 190, 229 85, 154, 190, 229 85, 154, 190, 258 and 258 and 289 and 303 and 336 and 289 85, 154, 190, 258 85, 154, 190, 258 85, 154, 190, 289 85, 154, 190, 289 85, 154, 190, 303 and 303 and 336 and 303 and 336 and 336 85, 154, 225, 229 85, 154, 225, 229 85, 154, 225, 229 85, 154, 225, 229 85, 154, 225, 258 and 258 and 289 and 303 and 336 and 289 85, 154, 225, 258 85, 154, 225, 258 85, 154, 225, 289 85, 154, 225, 289 85, 154, 225, 303 and 303 and 336 and 303 and 336 and 336 85, 154, 229, 258 85, 154, 229, 258 85, 154, 229, 258 85, 154, 229, 289 85, 154, 229, 289 and 289 and 303 and 336 and 303 and 336 85, 154, 229, 303 85, 154, 258, 289 85, 154, 258, 289 85, 154, 258, 303 85, 154, 289, 303 and 336 and 303 and 336 and 336 and 336 85, 190, 225, 229 85, 190, 225, 229 85, 190, 225, 229 85, 190, 225, 229 85, 190, 225, 258 and 258 and 289 and 303 and 336 and 289 85, 190, 225, 258 85, 190, 225, 258 85, 190, 225, 289 85, 190, 225, 289 85, 190, 225, 303 and 303 and 336 and 303 and 336 and 336 85, 190, 229, 258 85, 190, 229, 258 85, 190, 229, 258 85, 190, 229, 289 85, 190, 229, 289 and 289 and 303 and 336 and 303 and 336 85, 190, 229, 303 85, 190, 258, 289 85, 190, 258, 289 85, 190, 258, 303 85, 190, 289, 303 and 336 and 303 and 336 and 336 and 336 85, 225, 229, 258 85, 225, 229, 258 85, 225, 229, 258 85, 225, 229, 289 85, 225, 229, 289 and 289 and 303 and 336 and 303 and 336 85, 225, 229, 303 85, 225, 258, 289 85, 225, 258, 289 85, 225, 258, 303 85, 225, 289, 303 and 336 and 303 and 336 and 336 and 336 85, 229, 258, 289 85, 229, 258, 289 85, 229, 258, 303 85, 229, 289, 303 85, 258, 289, 303 and 303 and 336 and 336 and 336 and 336 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 154 and 190 154 and 225 154 and 229 154 and 258 154 and 289 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 154 and 303 154 and 336 190 and 225 190 and 229 190 and 258 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 190 and 289 190 and 303 190 and 336 225 and 229 225 and 258 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 225 and 289 225 and 303 225 and 336 229 and 258 229 and 289 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 134, 229 and 303 229 and 336 258 and 289 258 and 303 258 and 336 121, 130, 134, 121, 130, 134, 121, 130, 134, 121, 130, 154, 121, 130, 154, 289 and 303 289 and 336 303 and 336 190 and 225 190 and 229 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 190 and 258 190 and 289 190 and 303 190 and 336 225 and 229 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 225 and 258 225 and 289 225 and 303 225 and 336 229 and 258 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 154, 121, 130, 190, 258 and 336 289 and 303 289 and 336 303 and 336 225 and 229 121, 130, 190, 121, 130, 190, 121, 130, 190, 121, 130, 190, 121, 130, 190, 225 and 258 225 and 289 225 and 303 225 and 336 229 and 258 121, 130, 190, 121, 130, 190, 121, 130, 190, 121, 130, 190, 121, 130, 190, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 121, 130, 190, 121, 130, 190, 121, 130, 190, 121, 130, 190, 121, 130, 225, 258 and 336 289 and 303 289 and 336 303 and 336 229 and 258 121, 130, 225, 121, 130, 225, 121, 130, 225, 121, 130, 225, 121, 130, 225, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 121, 130, 225, 121, 130, 225, 121, 130, 225, 121, 130, 225, 121, 130, 229, 258 and 336 289 and 303 289 and 336 303 and 336 258 and 289 121, 130, 229, 121, 130, 229, 121, 130, 229, 121, 130, 229, 121, 130, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 130, 258, 121, 130, 258, 121, 130, 258, 121, 130, 289, 121, 134, 154, 289 and 303 289 and 336 303 and 336 303 and 336 190 and 225 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 190 and 229 190 and 258 190 and 289 190 and 303 190 and 336 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 225 and 229 225 and 258 225 and 289 225 and 303 225 and 336 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 121, 134, 154, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 134, 190, 121, 134, 190, 121, 134, 190, 121, 134, 190, 121, 134, 190, 225 and 229 225 and 258 225 and 289 225 and 303 225 and 336 121, 134, 190, 121, 134, 190, 121, 134, 190, 121, 134, 190, 121, 134, 190, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 121, 134, 190, 121, 134, 190, 121, 134, 190, 121, 134, 190, 121, 134, 190, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 134, 225, 121, 134, 225, 121, 134, 225, 121, 134, 225, 121, 134, 225, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 121, 134, 225, 121, 134, 225, 121, 134, 225, 121, 134, 225, 121, 134, 225, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 134, 229, 121, 134, 229, 121, 134, 229, 121, 134, 229, 121, 134, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 121, 134, 229, 121, 134, 258, 121, 134, 258, 121, 134, 258, 121, 134, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 121, 154, 190, 121, 154, 190, 121, 154, 190, 121, 154, 190, 121, 154, 190, 225 and 229 225 and 258 225 and 289 225 and 303 225 and 336 121, 154, 190, 121, 154, 190, 121, 154, 190, 121, 154, 190, 121, 154, 190, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 121, 154, 190, 121, 154, 190, 121, 154, 190, 121, 154, 190, 121, 154, 190, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 154, 225, 121, 154, 225, 121, 154, 225, 121, 154, 225, 121, 154, 225, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 121, 154, 225, 121, 154, 225, 121, 154, 225, 121, 154, 225, 121, 154, 225, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 154, 229, 121, 154, 229, 121, 154, 229, 121, 154, 229, 121, 154, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 121, 154, 229, 121, 154, 258, 121, 154, 258, 121, 154, 258, 121, 154, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 121, 190, 225, 121, 190, 225, 121, 190, 225, 121, 190, 225, 121, 190, 225, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 121, 190, 225, 121, 190, 225, 121, 190, 225, 121, 190, 225, 121, 190, 225, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 121, 190, 229, 121, 190, 229, 121, 190, 229, 121, 190, 229, 121, 190, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 121, 190, 229, 121, 190, 258, 121, 190, 258, 121, 190, 258, 121, 190, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 121, 225, 229, 121, 225, 229, 121, 225, 229, 121, 225, 229, 121, 225, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 121, 225, 229, 121, 225, 258, 121, 225, 258, 121, 225, 258, 121, 225, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 121, 229, 258, 121, 229, 258, 121, 229, 258, 121, 229, 289, 121, 258, 289, 289 and 303 289 and 336 303 and 336 303 and 336 303 and 336 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 190 and 225 190 and 229 190 and 258 190 and 289 190 and 303 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 190 and 336 225 and 229 225 and 258 225 and 289 225 and 303 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 225 and 336 229 and 258 229 and 289 229 and 303 229 and 336 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 130, 134, 154, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 130, 134, 154, 130, 134, 190, 130, 134, 190, 130, 134, 190, 130, 134, 190, 303 and 336 225 and 229 225 and 258 225 and 289 225 and 303 130, 134, 190, 130, 134, 190, 130, 134, 190, 130, 134, 190, 130, 134, 190, 225 and 336 229 and 258 229 and 289 229 and 303 229 and 336 130, 134, 190, 130, 134, 190, 130, 134, 190, 130, 134, 190, 130, 134, 190, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 130, 134, 190, 130, 134, 225, 130, 134, 225, 130, 134, 225, 130, 134, 225, 303 and 336 229 and 258 229 and 289 229 and 303 229 and 336 130, 134, 225, 130, 134, 225, 130, 134, 225, 130, 134, 225, 130, 134, 225, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 130, 134, 225, 130, 134, 229, 130, 134, 229, 130, 134, 229, 130, 134, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 130, 134, 229, 130, 134, 229, 130, 134, 258, 130, 134, 258, 130, 134, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 130, 134, 289, 130, 154, 190, 130, 154, 190, 130, 154, 190, 130, 154, 190, 303 and 336 225 and 229 225 and 258 225 and 289 225 and 303 130, 154, 190, 130, 154, 190, 130, 154, 190, 130, 154, 190, 130, 154, 190, 225 and 336 229 and 258 229 and 289 229 and 303 229 and 336 130, 154, 190, 130, 154, 190, 130, 154, 190, 130, 154, 190, 130, 154, 190, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 130, 154, 190, 130, 154, 225, 130, 154, 225, 130, 154, 225, 130, 154, 225, 303 and 336 229 and 258 229 and 289 229 and 303 229 and 336 130, 154, 225, 130, 154, 225, 130, 154, 225, 130, 154, 225, 130, 154, 225, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 130, 154, 225, 130, 154, 229, 130, 154, 229, 130, 154, 229, 130, 154, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 130, 154, 229, 130, 154, 229, 130, 154, 258, 130, 154, 258, 130, 154, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 130, 154, 289, 130, 190, 225, 130, 190, 225, 130, 190, 225, 130, 190, 225, 303 and 336 229 and 258 229 and 289 229 and 303 229 and 336 130, 190, 225, 130, 190, 225, 130, 190, 225, 130, 190, 225, 130, 190, 225, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 130, 190, 225, 130, 190, 229, 130, 190, 229, 130, 190, 229, 130, 190, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 130, 190, 229, 130, 190, 229, 130, 190, 258, 130, 190, 258, 130, 190, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 130, 190, 289, 130, 225, 229, 130, 225, 229, 130, 225, 229, 130, 225, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 130, 225, 229, 130, 225, 229, 130, 225, 258, 130, 225, 258, 130, 225, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 130, 225, 289, 130, 229, 258, 130, 229, 258, 130, 229, 258, 130, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 130, 258, 289, 134, 154, 190, 134, 154, 190, 134, 154, 190, 134, 154, 190, 303 and 336 225 and 229 225 and 258 225 and 289 225 and 303 134, 154, 190, 134, 154, 190, 134, 154, 190, 134, 154, 190, 134, 154, 190, 225 and 336 229 and 258 229 and 289 229 and 303 229 and 336 134, 154, 190, 134, 154, 190, 134, 154, 190, 134, 154, 190, 134, 154, 190, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 134, 154, 190, 134, 154, 225, 134, 154, 225, 134, 154, 225, 134, 154, 225, 303 and 336 229 and 258 229 and 289 229 and 303 229 and 336 134, 154, 225, 134, 154, 225, 134, 154, 225, 134, 154, 225, 134, 154, 225, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 134, 154, 225, 134, 154, 229, 134, 154, 229, 134, 154, 229, 134, 154, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 134, 154, 229, 134, 154, 229, 134, 154, 258, 134, 154, 258, 134, 154, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 134, 154, 289, 134, 190, 225, 134, 190, 225, 134, 190, 225, 134, 190, 225, 303 and 336 229 and 258 229 and 289 229 and 303 229 and 336 134, 190, 225, 134, 190, 225, 134, 190, 225, 134, 190, 225, 134, 190, 225, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 134, 190, 225, 134, 190, 229, 134, 190, 229, 134, 190, 229, 134, 190, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 134, 190, 229, 134, 190, 229, 134, 190, 258, 134, 190, 258, 134, 190, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 134, 190, 289, 134, 225, 229, 134, 225, 229, 134, 225, 229, 134, 225, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 134, 225, 229, 134, 225, 229, 134, 225, 258, 134, 225, 258, 134, 225, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 134, 225, 289, 134, 229, 258, 134, 229, 258, 134, 229, 258, 134, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 134, 258, 289, 154, 190, 225, 154, 190, 225, 154, 190, 225, 154, 190, 225, 303 and 336 229 and 258 229 and 289 229 and 303 229 and 336 154, 190, 225, 154, 190, 225, 154, 190, 225, 154, 190, 225, 154, 190, 225, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 154, 190, 225, 154, 190, 229, 154, 190, 229, 154, 190, 229, 154, 190, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 154, 190, 229, 154, 190, 229, 154, 190, 258, 154, 190, 258, 154, 190, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 154, 190, 289, 154, 225, 229, 154, 225, 229, 154, 225, 229, 154, 225, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 154, 225, 229, 154, 225, 229, 154, 225, 258, 154, 225, 258, 154, 225, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 154, 225, 289, 154, 229, 258, 154, 229, 258, 154, 229, 258, 154, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 154, 258, 289, 190, 225, 229, 190, 225, 229, 190, 225, 229, 190, 225, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 190, 225, 229, 190, 225, 229, 190, 225, 258, 190, 225, 258, 190, 225, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 190, 225, 289, 190, 229, 258, 190, 229, 258, 190, 229, 258, 190, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 190, 258, 289, 225, 229, 258, 225, 229, 258, 225, 229, 258, 225, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 225, 258, 289, 229, 258, 289, 303 and 336 303 and 336 85, 121, 130, 134, 154 and 85, 121, 130, 134, 154 and 85, 121, 130, 134, 154 and 85, 121, 130, 134, 154 and 85, 121, 130, 134, 154 and 190 225 229 258 289 85, 121, 130, 134, 154 and 85, 121, 130, 134, 154 and 85, 121, 130, 134, 190 and 85, 121, 130, 134, 190 and 85, 121, 130, 134, 190 and 303 336 225 229 258 85, 121, 130, 134, 190 and 85, 121, 130, 134, 190 and 85, 121, 130, 134, 190 and 85, 121, 130, 134, 225 and 85, 121, 130, 134, 225 and 289 303 336 229 258 85, 121, 130, 134, 225 and 85, 121, 130, 134, 225 and 85, 121, 130, 134, 225 and 85, 121, 130, 134, 229 and 85, 121, 130, 134, 229 and 289 303 336 258 289 85, 121, 130, 134, 229 and 85, 121, 130, 134, 229 and 85, 121, 130, 134, 258 and 85, 121, 130, 134, 258 and 85, 121, 130, 134, 258 and 303 336 289 303 336 85, 121, 130, 134, 289 and 85, 121, 130, 134, 289 and 85, 121, 130, 134, 303 and 85, 121, 130, 154, 190 and 85, 121, 130, 154, 190 and 303 336 336 225 229 85, 121, 130, 154, 190 and 85, 121, 130, 154, 190 and 85, 121, 130, 154, 190 and 85, 121, 130, 154, 190 and 85, 121, 130, 154, 225 and 258 289 303 336 229 85, 121, 130, 154, 225 and 85, 121, 130, 154, 225 and 85, 121, 130, 154, 225 and 85, 121, 130, 154, 225 and 85, 121, 130, 154, 229 and 258 289 303 336 258 85, 121, 130, 154, 229 and 85, 121, 130, 154, 229 and 85, 121, 130, 154, 229 and 85, 121, 130, 154, 258 and 85, 121, 130, 154, 258 and 289 303 336 289 303 85, 121, 130, 154, 258 and 85, 121, 130, 154, 289 and 85, 121, 130, 154, 289 and 85, 121, 130, 154, 303 and 85, 121, 130, 190, 225 and 336 303 336 336 229 85, 121, 130, 190, 225 and 85, 121, 130, 190, 225 and 85, 121, 130, 190, 225 and 85, 121, 130, 190, 225 and 85, 121, 130, 190, 229 and 258 289 303 336 258 85, 121, 130, 190, 229 and 85, 121, 130, 190, 229 and 85, 121, 130, 190, 229 and 85, 121, 130, 190, 258 and 85, 121, 130, 190, 258 and 289 303 336 289 303 85, 121, 130, 190, 258 and 85, 121, 130, 190, 289 and 85, 121, 130, 190, 289 and 85, 121, 130, 190, 303 and 85, 121, 130, 225, 229 and 336 303 336 336 258 85, 121, 130, 225, 229 and 85, 121, 130, 225, 229 and 85, 121, 130, 225, 229 and 85, 121, 130, 225, 258 and 85, 121, 130, 225, 258 and 289 303 336 289 303 85, 121, 130, 225, 258 and 85, 121, 130, 225, 289 and 85, 121, 130, 225, 289 and 85, 121, 130, 225, 303 and 85, 121, 130, 229, 258 and 336 303 336 336 289 85, 121, 130, 229, 258 and 85, 121, 130, 229, 258 and 85, 121, 130, 229, 289 and 85, 121, 130, 229, 289 and 85, 121, 130, 229, 303 and 303 336 303 336 336 85, 121, 130, 258, 289 and 85, 121, 130, 258, 289 and 85, 121, 130, 258, 303 and 85, 121, 130, 289, 303 and 85, 121, 134, 154, 190 and 303 336 336 336 225 85, 121, 134, 154, 190 and 85, 121, 134, 154, 190 and 85, 121, 134, 154, 190 and 85, 121, 134, 154, 190 and 85, 121, 134, 154, 190 and 229 258 289 303 336 85, 121, 134, 154, 225 and 85, 121, 134, 154, 225 and 85, 121, 134, 154, 225 and 85, 121, 134, 154, 225 and 85, 121, 134, 154, 225 and 229 258 289 303 336 85, 121, 134, 154, 229 and 85, 121, 134, 154, 229 and 85, 121, 134, 154, 229 and 85, 121, 134, 154, 229 and 85, 121, 134, 154, 258 and 258 289 303 336 289 85, 121, 134, 154, 258 and 85, 121, 134, 154, 258 and 85, 121, 134, 154, 289 and 85, 121, 134, 154, 289 and 85, 121, 134, 154, 303 and 303 336 303 336 336 85, 121, 134, 190, 225 and 85, 121, 134, 190, 225 and 85, 121, 134, 190, 225 and 85, 121, 134, 190, 225 and 85, 121, 134, 190, 225 and 229 258 289 303 336 85, 121, 134, 190, 229 and 85, 121, 134, 190, 229 and 85, 121, 134, 190, 229 and 85, 121, 134, 190, 229 and 85, 121, 134, 190, 258 and 258 289 303 336 289 85, 121, 134, 190, 258 and 85, 121, 134, 190, 258 and 85, 121, 134, 190, 289 and 85, 121, 134, 190, 289 and 85, 121, 134, 190, 303 and 303 336 303 336 336 85, 121, 134, 225, 229 and 85, 121, 134, 225, 229 and 85, 121, 134, 225, 229 and 85, 121, 134, 225, 229 and 85, 121, 134, 225, 258 and 258 289 303 336 289 85, 121, 134, 225, 258 and 85, 121, 134, 225, 258 and 85, 121, 134, 225, 289 and 85, 121, 134, 225, 289 and 85, 121, 134, 225, 303 and 303 336 303 336 336 85, 121, 134, 229, 258 and 85, 121, 134, 229, 258 and 85, 121, 134, 229, 258 and 85, 121, 134, 229, 289 and 85, 121, 134, 229, 289 and 289 303 336 303 336 85, 121, 134, 229, 303 and 85, 121, 134, 258, 289 and 85, 121, 134, 258, 289 and 85, 121, 134, 258, 303 and 85, 121, 134, 289, 303 and 336 303 336 336 336 85, 121, 154, 190, 225 and 85, 121, 154, 190, 225 and 85, 121, 154, 190, 225 and 85, 121, 154, 190, 225 and 85, 121, 154, 190, 225 and 229 258 289 303 336 85, 121, 154, 190, 229 and 85, 121, 154, 190, 229 and 85, 121, 154, 190, 229 and 85, 121, 154, 190, 229 and 85, 121, 154, 190, 258 and 258 289 303 336 289 85, 121, 154, 190, 258 and 85, 121, 154, 190, 258 and 85, 121, 154, 190, 289 and 85, 121, 154, 190, 289 and 85, 121, 154, 190, 303 and 303 336 303 336 336 85, 121, 154, 225, 229 and 85, 121, 154, 225, 229 and 85, 121, 154, 225, 229 and 85, 121, 154, 225, 229 and 85, 121, 154, 225, 258 and 258 289 303 336 289 85, 121, 154, 225, 258 and 85, 121, 154, 225, 258 and 85, 121, 154, 225, 289 and 85, 121, 154, 225, 289 and 85, 121, 154, 225, 303 and 303 336 303 336 336 85, 121, 154, 229, 258 and 85, 121, 154, 229, 258 and 85, 121, 154, 229, 258 and 85, 121, 154, 229, 289 and 85, 121, 154, 229, 289 and 289 303 336 303 336 85, 121, 154, 229, 303 and 85, 121, 154, 258, 289 and 85, 121, 154, 258, 289 and 85, 121, 154, 258, 303 and 85, 121, 154, 289, 303 and 336 303 336 336 336 85, 121, 190, 225, 229 and 85, 121, 190, 225, 229 and 85, 121, 190, 225, 229 and 85, 121, 190, 225, 229 and 85, 121, 190, 225, 258 and 258 289 303 336 289 85, 121, 190, 225, 258 and 85, 121, 190, 225, 258 and 85, 121, 190, 225, 289 and 85, 121, 190, 225, 289 and 85, 121, 190, 225, 303 and 303 336 303 336 336 85, 121, 190, 229, 258 and 85, 121, 190, 229, 258 and 85, 121, 190, 229, 258 and 85, 121, 190, 229, 289 and 85, 121, 190, 229, 289 and 289 303 336 303 336 85, 121, 190, 229, 303 and 85, 121, 190, 258, 289 and 85, 121, 190, 258, 289 and 85, 121, 190, 258, 303 and 85, 121, 190, 289, 303 and 336 303 336 336 336 85, 121, 225, 229, 258 and 85, 121, 225, 229, 258 and 85, 121, 225, 229, 258 and 85, 121, 225, 229, 289 and 85, 121, 225, 229, 289 and 289 303 336 303 336 85, 121, 225, 229, 303 and 85, 121, 225, 258, 289 and 85, 121, 225, 258, 289 and 85, 121, 225, 258, 303 and 85, 121, 225, 289, 303 and 336 303 336 336 336 85, 121, 229, 258, 289 and 85, 121, 229, 258, 289 and 85, 121, 229, 258, 303 and 85, 121, 229, 289, 303 and 85, 121, 258, 289, 303 and 303 336 336 336 336 85, 130, 134, 154, 190 and 85, 130, 134, 154, 190 and 85, 130, 134, 154, 190 and 85, 130, 134, 154, 190 and 85, 130, 134, 154, 190 and 225 229 258 289 303 85, 130, 134, 154, 190 and 85, 130, 134, 154, 225 and 85, 130, 134, 154, 225 and 85, 130, 134, 154, 225 and 85, 130, 134, 154, 225 and 336 229 258 289 303 85, 130, 134, 154, 225 and 85, 130, 134, 154, 229 and 85, 130, 134, 154, 229 and 85, 130, 134, 154, 229 and 85, 130, 134, 154, 229 and 336 258 289 303 336 85, 130, 134, 154, 258 and 85, 130, 134, 154, 258 and 85, 130, 134, 154, 258 and 85, 130, 134, 154, 289 and 85, 130, 134, 154, 289 and 289 303 336 303 336 85, 130, 134, 154, 303 and 85, 130, 134, 190, 225 and 85, 130, 134, 190, 225 and 85, 130, 134, 190, 225 and 85, 130, 134, 190, 225 and 336 229 258 289 303 85, 130, 134, 190, 225 and 85, 130, 134, 190, 229 and 85, 130, 134, 190, 229 and 85, 130, 134, 190, 229 and 85, 130, 134, 190, 229 and 336 258 289 303 336 85, 130, 134, 190, 258 and 85, 130, 134, 190, 258 and 85, 130, 134, 190, 258 and 85, 130, 134, 190, 289 and 85, 130, 134, 190, 289 and 289 303 336 303 336 85, 130, 134, 190, 303 and 85, 130, 134, 225, 229 and 85, 130, 134, 225, 229 and 85, 130, 134, 225, 229 and 85, 130, 134, 225, 229 and 336 258 289 303 336 85, 130, 134, 225, 258 and 85, 130, 134, 225, 258 and 85, 130, 134, 225, 258 and 85, 130, 134, 225, 289 and 85, 130, 134, 225, 289 and 289 303 336 303 336 85, 130, 134, 225, 303 and 85, 130, 134, 229, 258 and 85, 130, 134, 229, 258 and 85, 130, 134, 229, 258 and 85, 130, 134, 229, 289 and 336 289 303 336 303 85, 130, 134, 229, 289 and 85, 130, 134, 229, 303 and 85, 130, 134, 258, 289 and 85, 130, 134, 258, 289 and 85, 130, 134, 258, 303 and 336 336 303 336 336 85, 130, 134, 289, 303 and 85, 130, 154, 190, 225 and 85, 130, 154, 190, 225 and 85, 130, 154, 190, 225 and 85, 130, 154, 190, 225 and 336 229 258 289 303 85, 130, 154, 190, 225 and 85, 130, 154, 190, 229 and 85, 130, 154, 190, 229 and 85, 130, 154, 190, 229 and 85, 130, 154, 190, 229 and 336 258 289 303 336 85, 130, 154, 190, 258 and 85, 130, 154, 190, 258 and 85, 130, 154, 190, 258 and 85, 130, 154, 190, 289 and 85, 130, 154, 190, 289 and 289 303 336 303 336 85, 130, 154, 190, 303 and 85, 130, 154, 225, 229 and 85, 130, 154, 225, 229 and 85, 130, 154, 225, 229 and 85, 130, 154, 225, 229 and 336 258 289 303 336 85, 130, 154, 225, 258 and 85, 130, 154, 225, 258 and 85, 130, 154, 225, 258 and 85, 130, 154, 225, 289 and 85, 130, 154, 225, 289 and 289 303 336 303 336 85, 130, 154, 225, 303 and 85, 130, 154, 229, 258 and 85, 130, 154, 229, 258 and 85, 130, 154, 229, 258 and 85, 130, 154, 229, 289 and 336 289 303 336 303 85, 130, 154, 229, 289 and 85, 130, 154, 229, 303 and 85, 130, 154, 258, 289 and 85, 130, 154, 258, 289 and 85, 130, 154, 258, 303 and 336 336 303 336 336 85, 130, 154, 289, 303 and 85, 130, 190, 225, 229 and 85, 130, 190, 225, 229 and 85, 130, 190, 225, 229 and 85, 130, 190, 225, 229 and 336 258 289 303 336 85, 130, 190, 225, 258 and 85, 130, 190, 225, 258 and 85, 130, 190, 225, 258 and 85, 130, 190, 225, 289 and 85, 130, 190, 225, 289 and 289 303 336 303 336 85, 130, 190, 225, 303 and 85, 130, 190, 229, 258 and 85, 130, 190, 229, 258 and 85, 130, 190, 229, 258 and 85, 130, 190, 229, 289 and 336 289 303 336 303 85, 130, 190, 229, 289 and 85, 130, 190, 229, 303 and 85, 130, 190, 258, 289 and 85, 130, 190, 258, 289 and 85, 130, 190, 258, 303 and 336 336 303 336 336 85, 130, 190, 289, 303 and 85, 130, 225, 229, 258 and 85, 130, 225, 229, 258 and 85, 130, 225, 229, 258 and 85, 130, 225, 229, 289 and 336 289 303 336 303 85, 130, 225, 229, 289 and 85, 130, 225, 229, 303 and 85, 130, 225, 258, 289 and 85, 130, 225, 258, 289 and 85, 130, 225, 258, 303 and 336 336 303 336 336 85, 130, 225, 289, 303 and 85, 130, 229, 258, 289 and 85, 130, 229, 258, 289 and 85, 130, 229, 258, 303 and 85, 130, 229, 289, 303 and 336 303 336 336 336 85, 130, 258, 289, 303 and 85, 134, 154, 190, 225 and 85, 134, 154, 190, 225 and 85, 134, 154, 190, 225 and 85, 134, 154, 190, 225 and 336 229 258 289 303 85, 134, 154, 190, 225 and 85, 134, 154, 190, 229 and 85, 134, 154, 190, 229 and 85, 134, 154, 190, 229 and 85, 134, 154, 190, 229 and 336 258 289 303 336 85, 134, 154, 190, 258 and 85, 134, 154, 190, 258 and 85, 134, 154, 190, 258 and 85, 134, 154, 190, 289 and 85, 134, 154, 190, 289 and 289 303 336 303 336 85, 134, 154, 190, 303 and 85, 134, 154, 225, 229 and 85, 134, 154, 225, 229 and 85, 134, 154, 225, 229 and 85, 134, 154, 225, 229 and 336 258 289 303 336 85, 134, 154, 225, 258 and 85, 134, 154, 225, 258 and 85, 134, 154, 225, 258 and 85, 134, 154, 225, 289 and 85, 134, 154, 225, 289 and 289 303 336 303 336 85, 134, 154, 225, 303 and 85, 134, 154, 229, 258 and 85, 134, 154, 229, 258 and 85, 134, 154, 229, 258 and 85, 134, 154, 229, 289 and 336 289 303 336 303 85, 134, 154, 229, 289 and 85, 134, 154, 229, 303 and 85, 134, 154, 258, 289 and 85, 134, 154, 258, 289 and 85, 134, 154, 258, 303 and 336 336 303 336 336 85, 134, 154, 289, 303 and 85, 134, 190, 225, 229 and 85, 134, 190, 225, 229 and 85, 134, 190, 225, 229 and 85, 134, 190, 225, 229 and 336 258 289 303 336 85, 134, 190, 225, 258 and 85, 134, 190, 225, 258 and 85, 134, 190, 225, 258 and 85, 134, 190, 225, 289 and 85, 134, 190, 225, 289 and 289 303 336 303 336 85, 134, 190, 225, 303 and 85, 134, 190, 229, 258 and 85, 134, 190, 229, 258 and 85, 134, 190, 229, 258 and 85, 134, 190, 229, 289 and 336 289 303 336 303 85, 134, 190, 229, 289 and 85, 134, 190, 229, 303 and 85, 134, 190, 258, 289 and 85, 134, 190, 258, 289 and 85, 134, 190, 258, 303 and 336 336 303 336 336 85, 134, 190, 289, 303 and 85, 134, 225, 229, 258 and 85, 134, 225, 229, 258 and 85, 134, 225, 229, 258 and 85, 134, 225, 229, 289 and 336 289 303 336 303 85, 134, 225, 229, 289 and 85, 134, 225, 229, 303 and 85, 134, 225, 258, 289 and 85, 134, 225, 258, 289 and 85, 134, 225, 258, 303 and 336 336 303 336 336 85, 134, 225, 289, 303 and 85, 134, 229, 258, 289 and 85, 134, 229, 258, 289 and 85, 134, 229, 258, 303 and 85, 134, 229, 289, 303 and 336 303 336 336 336 85, 134, 258, 289, 303 and 85, 154, 190, 225, 229 and 85, 154, 190, 225, 229 and 85, 154, 190, 225, 229 and 85, 154, 190, 225, 229 and 336 258 289 303 336 85, 154, 190, 225, 258 and 85, 154, 190, 225, 258 and 85, 154, 190, 225, 258 and 85, 154, 190, 225, 289 and 85, 154, 190, 225, 289 and 289 303 336 303 336 85, 154, 190, 225, 303 and 85, 154, 190, 229, 258 and 85, 154, 190, 229, 258 and 85, 154, 190, 229, 258 and 85, 154, 190, 229, 289 and 336 289 303 336 303 85, 154, 190, 229, 289 and 85, 154, 190, 229, 303 and 85, 154, 190, 258, 289 and 85, 154, 190, 258, 289 and 85, 154, 190, 258, 303 and 336 336 303 336 336 85, 154, 190, 289, 303 and 85, 154, 225, 229, 258 and 85, 154, 225, 229, 258 and 85, 154, 225, 229, 258 and 85, 154, 225, 229, 289 and 336 289 303 336 303 85, 154, 225, 229, 289 and 85, 154, 225, 229, 303 and 85, 154, 225, 258, 289 and 85, 154, 225, 258, 289 and 85, 154, 225, 258, 303 and 336 336 303 336 336 85, 154, 225, 289, 303 and 85, 154, 229, 258, 289 and 85, 154, 229, 258, 289 and 85, 154, 229, 258, 303 and 85, 154, 229, 289, 303 and 336 303 336 336 336 85, 154, 258, 289, 303 and 85, 190, 225, 229, 258 and 85, 190, 225, 229, 258 and 85, 190, 225, 229, 258 and 85, 190, 225, 229, 289 and 336 289 303 336 303 85, 190, 225, 229, 289 and 85, 190, 225, 229, 303 and 85, 190, 225, 258, 289 and 85, 190, 225, 258, 289 and 85, 190, 225, 258, 303 and 336 336 303 336 336 85, 190, 225, 289, 303 and 85, 190, 229, 258, 289 and 85, 190, 229, 258, 289 and 85, 190, 229, 258, 303 and 85, 190, 229, 289, 303 and 336 303 336 336 336 85, 190, 258, 289, 303 and 85, 225, 229, 258, 289 and 85, 225, 229, 258, 289 and 85, 225, 229, 258, 303 and 85, 225, 229, 289, 303 and 336 303 336 336 336 85, 225, 258, 289, 303 and 85, 229, 258, 289, 303 and 121, 130, 134, 154, 190 and 121, 130, 134, 154, 190 and 121, 130, 134, 154, 190 336 336 225 229 and 258 121, 130, 134, 154, 190 121, 130, 134, 154, 190 121, 130, 134, 154, 190 121, 130, 134, 154, 225 121, 130, 134, 154, 225 and 289 and 303 and 336 and 229 and 258 121, 130, 134, 154, 225 121, 130, 134, 154, 225 121, 130, 134, 154, 225 121, 130, 134, 154, 229 121, 130, 134, 154, 229 and 289 and 303 and 336 and 258 and 289 121, 130, 134, 154, 229 121, 130, 134, 154, 229 121, 130, 134, 154, 258 121, 130, 134, 154, 258 121, 130, 134, 154, 258 and 303 and 336 and 289 and 303 and 336 121, 130, 134, 154, 289 121, 130, 134, 154, 289 121, 130, 134, 154, 303 121, 130, 134, 190, 225 121, 130, 134, 190, 225 and 303 and 336 and 336 and 229 and 258 121, 130, 134, 190, 225 121, 130, 134, 190, 225 121, 130, 134, 190, 225 121, 130, 134, 190, 229 121, 130, 134, 190, 229 and 289 and 303 and 336 and 258 and 289 121, 130, 134, 190, 229 121, 130, 134, 190, 229 121, 130, 134, 190, 258 121, 130, 134, 190, 258 121, 130, 134, 190, 258 and 303 and 336 and 289 and 303 and 336 121, 130, 134, 190, 289 121, 130, 134, 190, 289 121, 130, 134, 190, 303 121, 130, 134, 225, 229 121, 130, 134, 225, 229 and 303 and 336 and 336 and 258 and 289 121, 130, 134, 225, 229 121, 130, 134, 225, 229 121, 130, 134, 225, 258 121, 130, 134, 225, 258 121, 130, 134, 225, 258 and 303 and 336 and 289 and 303 and 336 121, 130, 134, 225, 289 121, 130, 134, 225, 289 121, 130, 134, 225, 303 121, 130, 134, 229, 258 121, 130, 134, 229, 258 and 303 and 336 and 336 and 289 and 303 121, 130, 134, 229, 258 121, 130, 134, 229, 289 121, 130, 134, 229, 289 121, 130, 134, 229, 303 121, 130, 134, 258, 289 and 336 and 303 and 336 and 336 and 303 121, 130, 134, 258, 289 121, 130, 134, 258, 303 121, 130, 134, 289, 303 121, 130, 154, 190, 225 121, 130, 154, 190, 225 and 336 and 336 and 336 and 229 and 258 121, 130, 154, 190, 225 121, 130, 154, 190, 225 121, 130, 154, 190, 225 121, 130, 154, 190, 229 121, 130, 154, 190, 229 and 289 and 303 and 336 and 258 and 289 121, 130, 154, 190, 229 121, 130, 154, 190, 229 121, 130, 154, 190, 258 121, 130, 154, 190, 258 121, 130, 154, 190, 258 and 303 and 336 and 289 and 303 and 336 121, 130, 154, 190, 289 121, 130, 154, 190, 289 121, 130, 154, 190, 303 121, 130, 154, 225, 229 121, 130, 154, 225, 229 and 303 and 336 and 336 and 258 and 289 121, 130, 154, 225, 229 121, 130, 154, 225, 229 121, 130, 154, 225, 258 121, 130, 154, 225, 258 121, 130, 154, 225, 258 and 303 and 336 and 289 and 303 and 336 121, 130, 154, 225, 289 121, 130, 154, 225, 289 121, 130, 154, 225, 303 121, 130, 154, 229, 258 121, 130, 154, 229, 258 and 303 and 336 and 336 and 289 and 303 121, 130, 154, 229, 258 121, 130, 154, 229, 289 121, 130, 154, 229, 289 121, 130, 154, 229, 303 121, 130, 154, 258, 289 and 336 and 303 and 336 and 336 and 303 121, 130, 154, 258, 289 121, 130, 154, 258, 303 121, 130, 154, 289, 303 121, 130, 190, 225, 229 121, 130, 190, 225, 229 and 336 and 336 and 336 and 258 and 289 121, 130, 190, 225, 229 121, 130, 190, 225, 229 121, 130, 190, 225, 258 121, 130, 190, 225, 258 121, 130, 190, 225, 258 and 303 and 336 and 289 and 303 and 336 121, 130, 190, 225, 289 121, 130, 190, 225, 289 121, 130, 190, 225, 303 121, 130, 190, 229, 258 121, 130, 190, 229, 258 and 303 and 336 and 336 and 289 and 303 121, 130, 190, 229, 121, 130, 190, 229, 121, 130, 190, 229, 121, 130, 190, 229, 121, 130, 190, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 130, 190, 258, 121, 130, 190, 258, 121, 130, 190, 289, 121, 130, 225, 229, 121, 130, 225, 229, 289 and 336 303 and 336 303 and 336 258 and 289 258 and 303 121, 130, 225, 229, 121, 130, 225, 229, 121, 130, 225, 229, 121, 130, 225, 229, 121, 130, 225, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 130, 225, 258, 121, 130, 225, 258, 121, 130, 225, 289, 121, 130, 229, 258, 121, 130, 229, 258, 289 and 336 303 and 336 303 and 336 289 and 303 289 and 336 121, 130, 229, 258, 121, 130, 229, 289, 121, 130, 258, 289, 121, 134, 154, 190, 121, 134, 154, 190, 303 and 336 303 and 336 303 and 336 225 and 229 225 and 258 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 225 and 289 225 and 303 225 and 336 229 and 258 229 and 289 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 229 and 303 229 and 336 258 and 289 258 and 303 258 and 336 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 190, 121, 134, 154, 225, 121, 134, 154, 225, 289 and 303 289 and 336 303 and 336 229 and 258 229 and 289 121, 134, 154, 225, 121, 134, 154, 225, 121, 134, 154, 225, 121, 134, 154, 225, 121, 134, 154, 225, 229 and 303 229 and 336 258 and 289 258 and 303 258 and 336 121, 134, 154, 225, 121, 134, 154, 225, 121, 134, 154, 225, 121, 134, 154, 229, 121, 134, 154, 229, 289 and 303 289 and 336 303 and 336 258 and 289 258 and 303 121, 134, 154, 229, 121, 134, 154, 229, 121, 134, 154, 229, 121, 134, 154, 229, 121, 134, 154, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 134, 154, 258, 121, 134, 154, 258, 121, 134, 154, 289, 121, 134, 190, 225, 121, 134, 190, 225, 289 and 336 303 and 336 303 and 336 229 and 258 229 and 289 121, 134, 190, 225, 121, 134, 190, 225, 121, 134, 190, 225, 121, 134, 190, 225, 121, 134, 190, 225, 229 and 303 229 and 336 258 and 289 258 and 303 258 and 336 121, 134, 190, 225, 121, 134, 190, 225, 121, 134, 190, 225, 121, 134, 190, 229, 121, 134, 190, 229, 289 and 303 289 and 336 303 and 336 258 and 289 258 and 303 121, 134, 190, 229, 121, 134, 190, 229, 121, 134, 190, 229, 121, 134, 190, 229, 121, 134, 190, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 134, 190, 258, 121, 134, 190, 258, 121, 134, 190, 289, 121, 134, 225, 229, 121, 134, 225, 229, 289 and 336 303 and 336 303 and 336 258 and 289 258 and 303 121, 134, 225, 229, 121, 134, 225, 229, 121, 134, 225, 229, 121, 134, 225, 229, 121, 134, 225, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 134, 225, 258, 121, 134, 225, 258, 121, 134, 225, 289, 121, 134, 229, 258, 121, 134, 229, 258, 289 and 336 303 and 336 303 and 336 289 and 303 289 and 336 121, 134, 229, 258, 121, 134, 229, 289, 121, 134, 258, 289, 121, 154, 190, 225, 121, 154, 190, 225, 303 and 336 303 and 336 303 and 336 229 and 258 229 and 289 121, 154, 190, 225, 121, 154, 190, 225, 121, 154, 190, 225, 121, 154, 190, 225, 121, 154, 190, 225, 229 and 303 229 and 336 258 and 289 258 and 303 258 and 336 121, 154, 190, 225, 121, 154, 190, 225, 121, 154, 190, 225, 121, 154, 190, 229, 121, 154, 190, 229, 289 and 303 289 and 336 303 and 336 258 and 289 258 and 303 121, 154, 190, 229, 121, 154, 190, 229, 121, 154, 190, 229, 121, 154, 190, 229, 121, 154, 190, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 154, 190, 258, 121, 154, 190, 258, 121, 154, 190, 289, 121, 154, 225, 229, 121, 154, 225, 229, 289 and 336 303 and 336 303 and 336 258 and 289 258 and 303 121, 154, 225, 229, 121, 154, 225, 229, 121, 154, 225, 229, 121, 154, 225, 229, 121, 154, 225, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 154, 225, 258, 121, 154, 225, 258, 121, 154, 225, 289, 121, 154, 229, 258, 121, 154, 229, 258, 289 and 336 303 and 336 303 and 336 289 and 303 289 and 336 121, 154, 229, 258, 121, 154, 229, 289, 121, 154, 258, 289, 121, 190, 225, 229, 121, 190, 225, 229, 303 and 336 303 and 336 303 and 336 258 and 289 258 and 303 121, 190, 225, 229, 121, 190, 225, 229, 121, 190, 225, 229, 121, 190, 225, 229, 121, 190, 225, 258, 258 and 336 289 and 303 289 and 336 303 and 336 289 and 303 121, 190, 225, 258, 121, 190, 225, 258, 121, 190, 225, 289, 121, 190, 229, 258, 121, 190, 229, 258, 289 and 336 303 and 336 303 and 336 289 and 303 289 and 336 121, 190, 229, 258, 121, 190, 229, 289, 121, 190, 258, 289, 121, 225, 229, 258, 121, 225, 229, 258, 303 and 336 303 and 336 303 and 336 289 and 303 289 and 336 121, 225, 229, 258, 121, 225, 229, 289, 121, 225, 258, 289, 121, 229, 258, 289, 130, 134, 154, 190, 303 and 336 303 and 336 303 and 336 303 and 336 225 and 229 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 225 and 258 225 and 289 225 and 303 225 and 336 229 and 258 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 190, 130, 134, 154, 225, 258 and 336 289 and 303 289 and 336 303 and 336 229 and 258 130, 134, 154, 225, 130, 134, 154, 225, 130, 134, 154, 225, 130, 134, 154, 225, 130, 134, 154, 225, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 130, 134, 154, 225, 130, 134, 154, 225, 130, 134, 154, 225, 130, 134, 154, 225, 130, 134, 154, 229, 258 and 336 289 and 303 289 and 336 303 and 336 258 and 289 130, 134, 154, 229, 130, 134, 154, 229, 130, 134, 154, 229, 130, 134, 154, 229, 130, 134, 154, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 130, 134, 154, 258, 130, 134, 154, 258, 130, 134, 154, 258, 130, 134, 154, 289, 130, 134, 190, 225, 289 and 303 289 and 336 303 and 336 303 and 336 229 and 258 130, 134, 190, 225, 130, 134, 190, 225, 130, 134, 190, 225, 130, 134, 190, 225, 130, 134, 190, 225, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 130, 134, 190, 225, 130, 134, 190, 225, 130, 134, 190, 225, 130, 134, 190, 225, 130, 134, 190, 229, 258 and 336 289 and 303 289 and 336 303 and 336 258 and 289 130, 134, 190, 229, 130, 134, 190, 229, 130, 134, 190, 229, 130, 134, 190, 229, 130, 134, 190, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 130, 134, 190, 258, 130, 134, 190, 258, 130, 134, 190, 258, 130, 134, 190, 289, 130, 134, 225, 229, 289 and 303 289 and 336 303 and 336 303 and 336 258 and 289 130, 134, 225, 229, 130, 134, 225, 229, 130, 134, 225, 229, 130, 134, 225, 229, 130, 134, 225, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 130, 134, 225, 258, 130, 134, 225, 258, 130, 134, 225, 258, 130, 134, 225, 289, 130, 134, 229, 258, 289 and 303 289 and 336 303 and 336 303 and 336 289 and 303 130, 134, 229, 258, 130, 134, 229, 258, 130, 134, 229, 289, 130, 134, 258, 289, 130, 154, 190, 225, 289 and 336 303 and 336 303 and 336 303 and 336 229 and 258 130, 154, 190, 225, 130, 154, 190, 225, 130, 154, 190, 225, 130, 154, 190, 225, 130, 154, 190, 225, 229 and 289 229 and 303 229 and 336 258 and 289 258 and 303 130, 154, 190, 225, 130, 154, 190, 225, 130, 154, 190, 225, 130, 154, 190, 225, 130, 154, 190, 229, 258 and 336 289 and 303 289 and 336 303 and 336 258 and 289 130, 154, 190, 229, 130, 154, 190, 229, 130, 154, 190, 229, 130, 154, 190, 229, 130, 154, 190, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 130, 154, 190, 258, 130, 154, 190, 258, 130, 154, 190, 258, 130, 154, 190, 289, 130, 154, 225, 229, 289 and 303 289 and 336 303 and 336 303 and 336 258 and 289 130, 154, 225, 229, 130, 154, 225, 229, 130, 154, 225, 229, 130, 154, 225, 229, 130, 154, 225, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 130, 154, 225, 258, 130, 154, 225, 258, 130, 154, 225, 258, 130, 154, 225, 289, 130, 154, 229, 258, 289 and 303 289 and 336 303 and 336 303 and 336 289 and 303 130, 154, 229, 258, 130, 154, 229, 258, 130, 154, 229, 289, 130, 154, 258, 289, 130, 190, 225, 229, 289 and 336 303 and 336 303 and 336 303 and 336 258 and 289 130, 190, 225, 229, 130, 190, 225, 229, 130, 190, 225, 229, 130, 190, 225, 229, 130, 190, 225, 229, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 130, 190, 225, 258, 130, 190, 225, 258, 130, 190, 225, 258, 130, 190, 225, 289, 130, 190, 229, 258, 289 and 303 289 and 336 303 and 336 303 and 336 289 and 303 130, 190, 229, 258, 130, 190, 229, 258, 130, 190, 229, 289, 130, 190, 258, 289, 130, 225, 229, 258, 289 and 336 303 and 336 303 and 336 303 and 336 289 and 303 130, 225, 229, 258, 130, 225, 229, 258, 130, 225, 229, 289, 130, 225, 258, 289, 130, 229, 258, 289, 289 and 336 303 and 336 303 and 336 303 and 336 303 and 336 134, 154, 190, 225, 134, 154, 190, 225, 134, 154, 190, 225, 134, 154, 190, 225, 134, 154, 190, 225, 229 and 258 229 and 289 229 and 303 229 and 336 258 and 289 134, 154, 190, 225, 134, 154, 190, 225, 134, 154, 190, 225, 134, 154, 190, 225, 134, 154, 190, 225, 258 and 303 258 and 336 289 and 303 289 and 336 303 and 336 134, 154, 190, 229, 134, 154, 190, 229, 134, 154, 190, 229, 134, 154, 190, 229, 134, 154, 190, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 134, 154, 190, 229, 134, 154, 190, 258, 134, 154, 190, 258, 134, 154, 190, 258, 134, 154, 190, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 134, 154, 225, 229, 134, 154, 225, 229, 134, 154, 225, 229, 134, 154, 225, 229, 134, 154, 225, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 134, 154, 225, 229, 134, 154, 225, 258, 134, 154, 225, 258, 134, 154, 225, 258, 134, 154, 225, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 134, 154, 229, 258, 134, 154, 229, 258, 134, 154, 229, 258, 134, 154, 229, 289, 134, 154, 258, 289, 289 and 303 289 and 336 303 and 336 303 and 336 303 and 336 134, 190, 225, 229, 134, 190, 225, 229, 134, 190, 225, 229, 134, 190, 225, 229, 134, 190, 225, 229, 258 and 289 258 and 303 258 and 336 289 and 303 289 and 336 134, 190, 225, 229, 134, 190, 225, 258, 134, 190, 225, 258, 134, 190, 225, 258, 134, 190, 225, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 134, 190, 229, 258, 134, 190, 229, 258, 134, 190, 229, 258, 134, 190, 229, 289, 134, 190, 258, 289, 289 and 303 289 and 336 303 and 336 303 and 336 303 and 336 134, 225, 229, 258, 134, 225, 229, 258, 134, 225, 229, 258, 134, 225, 229, 289, 134, 225, 258, 289, 289 and 303 289 and 336 303 and 336 303 and 336 303 and 336 134, 229, 258, 289, 154, 190, 225, 229, 154, 190, 225, 229, 154, 190, 225, 229, 154, 190, 225, 229, 303 and 336 258 and 289 258 and 303 258 and 336 289 and 303 154, 190, 225, 229, 154, 190, 225, 229, 154, 190, 225, 258, 154, 190, 225, 258, 154, 190, 225, 258, 289 and 336 303 and 336 289 and 303 289 and 336 303 and 336 154, 190, 225, 289, 154, 190, 229, 258, 154, 190, 229, 258, 154, 190, 229, 258, 154, 190, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 154, 190, 258, 289, 154, 225, 229, 258, 154, 225, 229, 258, 154, 225, 229, 258, 154, 225, 229, 289, 303 and 336 289 and 303 289 and 336 303 and 336 303 and 336 154, 225, 258, 289, 154, 229, 258, 289, 190, 225, 229, 258, 190, 225, 229, 258, 190, 225, 229, 258, 303 and 336 303 and 336 289 and 303 289 and 336 303 and 336 190, 225, 229, 289, 190, 225, 258, 289, 190, 229, 258, 289, 225, 229, 258, 289, 85, 121, 130, 134, 303 and 336 303 and 336 303 and 336 303 and 336 154, 190 and 225 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 154, 190 and 229 154, 190 and 258 154, 190 and 289 154, 190 and 303 154, 190 and 336 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 154, 225 and 229 154, 225 and 258 154, 225 and 289 154, 225 and 303 154, 225 and 336 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 154, 229 and 258 154, 229 and 289 154, 229 and 303 154, 229 and 336 154, 258 and 289 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 154, 258 and 303 154, 258 and 336 154, 289 and 303 154, 289 and 336 154, 303 and 336 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 190, 225 and 229 190, 225 and 258 190, 225 and 289 190, 225 and 303 190, 225 and 336 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 190, 229 and 258 190, 229 and 289 190, 229 and 303 190, 229 and 336 190, 258 and 289 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 190, 258 and 303 190, 258 and 336 190, 289 and 303 190, 289 and 336 190, 303 and 336 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 85, 121, 130, 134, 225, 229 and 258 225, 229 and 289 225, 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154, 85, 121, 130, 154, 85, 121, 130, 154, 190, 258 and 303 190, 258 and 336 190, 289 and 303 190, 289 and 336 190, 303 and 336 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 225, 229 and 258 225, 229 and 289 225, 229 and 303 225, 229 and 336 225, 258 and 289 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 225, 258 and 303 225, 258 and 336 225, 289 and 303 225, 289 and 336 225, 303 and 336 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 229, 258 and 289 229, 258 and 303 229, 258 and 336 229, 289 and 303 229, 289 and 336 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 85, 121, 130, 154, 229, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 85, 121, 130, 190, 85, 121, 130, 190, 85, 121, 130, 190, 85, 121, 130, 190, 85, 121, 130, 190, 225, 229 and 258 225, 229 and 289 225, 229 and 303 225, 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154, 225, 121, 130, 134, 154, 225, 121, 130, 134, 154, 225, 121, 130, 134, 154, 225, 225, 229, 289 and 336 229, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 121, 130, 134, 154, 121, 130, 134, 154, 229, 121, 130, 134, 154, 229, 121, 130, 134, 154, 229, 121, 130, 134, 154, 229, 225, 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 121, 130, 134, 154, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 258, 289, 303 and 336 229, 258 and 289 229, 258 and 303 229, 258 and 336 229, 289 and 303 121, 130, 134, 190, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 225, 229, 289 and 336 229, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 121, 130, 134, 190, 121, 130, 134, 190, 229, 121, 130, 134, 190, 229, 121, 130, 134, 190, 229, 121, 130, 134, 190, 229, 225, 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 121, 130, 134, 190, 121, 130, 134, 225, 229, 121, 130, 134, 225, 229, 121, 130, 134, 225, 229, 121, 130, 134, 225, 229, 258, 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 121, 130, 134, 225, 121, 130, 134, 229, 258, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 258, 289, 303 and 336 289, 303 and 336 229, 258 and 289 229, 258 and 303 229, 258 and 336 121, 130, 154, 190, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 225, 229, 289 and 303 229, 289 and 336 229, 303 and 336 258, 289 and 303 258, 289 and 336 121, 130, 154, 190, 121, 130, 154, 190, 225, 121, 130, 154, 190, 229, 121, 130, 154, 190, 229, 121, 130, 154, 190, 229, 225, 258, 303 and 336 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 121, 130, 154, 190, 121, 130, 154, 190, 258, 121, 130, 154, 225, 229, 121, 130, 154, 225, 229, 121, 130, 154, 225, 229, 229, 289, 303 and 336 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 121, 130, 154, 225, 121, 130, 154, 225, 258, 121, 130, 154, 229, 258, 121, 130, 190, 225, 229, 121, 130, 190, 225, 229, 229, 289, 303 and 336 289, 303 and 336 289, 303 and 336 258, 289 and 303 258, 289 and 336 121, 130, 190, 225, 121, 130, 190, 225, 229, 121, 130, 190, 225, 258, 121, 130, 190, 229, 258, 121, 130, 225, 229, 258, 229, 258, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 121, 134, 154, 190, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 225, 229, 258 and 289 229, 258 and 303 229, 258 and 336 229, 289 and 303 229, 289 and 336 121, 134, 154, 190, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 225, 229, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 121, 134, 154, 190, 121, 134, 154, 190, 229, 121, 134, 154, 190, 229, 121, 134, 154, 190, 229, 121, 134, 154, 190, 258, 229, 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 289, 303 and 336 121, 134, 154, 225, 121, 134, 154, 225, 229, 121, 134, 154, 225, 229, 121, 134, 154, 225, 229, 121, 134, 154, 225, 258, 229, 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 289, 303 and 336 121, 134, 154, 229, 121, 134, 190, 225, 229, 121, 134, 190, 225, 229, 121, 134, 190, 225, 229, 121, 134, 190, 225, 229, 258, 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 121, 134, 190, 225, 121, 134, 190, 229, 258, 121, 134, 225, 229, 258, 121, 154, 190, 225, 229, 121, 154, 190, 225, 229, 258, 289, 303 and 336 289, 303 and 336 289, 303 and 336 258, 289 and 303 258, 289 and 336 121, 154, 190, 225, 121, 154, 190, 225, 229, 121, 154, 190, 225, 258, 121, 154, 190, 229, 258, 121, 154, 225, 229, 258, 229, 258, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 121, 190, 225, 229, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 258, 289, 303 and 336 229, 258 and 289 229, 258 and 303 229, 258 and 336 229, 289 and 303 130, 134, 154, 190, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 225, 229, 289 and 336 229, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 130, 134, 154, 190, 130, 134, 154, 190, 229, 130, 134, 154, 190, 229, 130, 134, 154, 190, 229, 130, 134, 154, 190, 229, 225, 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 130, 134, 154, 190, 130, 134, 154, 225, 229, 130, 134, 154, 225, 229, 130, 134, 154, 225, 229, 130, 134, 154, 225, 229, 258, 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 289, 303 and 336 130, 134, 154, 225, 130, 134, 154, 229, 258, 130, 134, 190, 225, 229, 130, 134, 190, 225, 229, 130, 134, 190, 225, 229, 258, 289, 303 and 336 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 130, 134, 190, 225, 130, 134, 190, 225, 258, 130, 134, 190, 229, 258, 130, 134, 225, 229, 258, 130, 154, 190, 225, 229, 229, 289, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 258, 289 and 303 130, 154, 190, 225, 130, 154, 190, 225, 229, 130, 154, 190, 225, 229, 130, 154, 190, 225, 258, 130, 154, 190, 229, 258, 229, 258, 289 and 336 258, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 130, 154, 225, 229, 130, 190, 225, 229, 258, 134, 154, 190, 225, 229, 134, 154, 190, 225, 229, 134, 154, 190, 225, 229, 258, 289, 303 and 336 289, 303 and 336 258, 289 and 303 258, 289 and 336 258, 303 and 336 134, 154, 190, 225, 134, 154, 190, 225, 258, 134, 154, 190, 229, 258, 134, 154, 225, 229, 258, 134, 190, 225, 229, 258, 229, 289, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 289, 303 and 336 154, 190, 225, 229, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 258, 289, 303 and 336 190, 225, 229 and 258 190, 225, 229 and 289 190, 225, 229 and 303 190, 225, 229 and 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 225, 258 and 289 190, 225, 258 and 303 190, 225, 258 and 336 190, 225, 289 and 303 190, 225, 289 and 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 225, 303 and 336 190, 229, 258 and 289 190, 229, 258 and 303 190, 229, 258 and 336 190, 229, 289 and 303 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 229, 289 and 336 190, 229, 303 and 336 190, 258, 289 and 303 190, 258, 289 and 336 190, 258, 303 and 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 289, 303 and 336 225, 229, 258 and 289 225, 229, 258 and 303 225, 229, 258 and 336 225, 229, 289 and 303 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 225, 229, 289 and 336 225, 229, 303 and 336 225, 258, 289 and 303 225, 258, 289 and 336 225, 258, 303 and 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 225, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 258, 289, 303 and 336 225, 229, 258 and 289 225, 229, 258 and 303 225, 229, 258 and 336 225, 229, 289 and 303 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 225, 229, 289 and 336 225, 229, 303 and 336 225, 258, 289 and 303 225, 258, 289 and 336 225, 258, 303 and 336 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 225, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 85, 121, 130, 134, 190, 85, 121, 130, 134, 225, 85, 121, 130, 134, 225, 85, 121, 130, 134, 225, 85, 121, 130, 134, 225, 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 85, 121, 130, 134, 225, 85, 121, 130, 134, 229, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 258, 289, 303 and 336 258, 289, 303 and 336 225, 229, 258 and 289 225, 229, 258 and 303 225, 229, 258 and 336 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 225, 229, 289 and 303 225, 229, 289 and 336 225, 229, 303 and 336 225, 258, 289 and 303 225, 258, 289 and 336 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 225, 258, 303 and 336 225, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 225, 85, 121, 130, 154, 225, 85, 121, 130, 154, 225, 229, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 85, 121, 130, 154, 225, 85, 121, 130, 154, 225, 85, 121, 130, 154, 229, 85, 121, 130, 190, 225, 85, 121, 130, 190, 225, 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 85, 121, 130, 190, 225, 85, 121, 130, 190, 225, 85, 121, 130, 190, 225, 85, 121, 130, 190, 229, 85, 121, 130, 225, 229, 229, 258, 303 and 336 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 225, 229, 258 and 289 225, 229, 258 and 303 225, 229, 258 and 336 225, 229, 289 and 303 225, 229, 289 and 336 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 225, 229, 303 and 336 225, 258, 289 and 303 225, 258, 289 and 336 225, 258, 303 and 336 225, 289, 303 and 336 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 258, 289, 303 and 336 85, 121, 134, 154, 225, 85, 121, 134, 154, 225, 85, 121, 134, 154, 225, 85, 121, 134, 154, 225, 85, 121, 134, 154, 225, 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 258, 289, 303 and 336 85, 121, 134, 154, 229, 85, 121, 134, 190, 225, 85, 121, 134, 190, 225, 85, 121, 134, 190, 225, 85, 121, 134, 190, 225, 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 85, 121, 134, 190, 225, 85, 121, 134, 190, 229, 85, 121, 134, 225, 229, 85, 121, 154, 190, 225, 85, 121, 154, 190, 225, 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 85, 121, 154, 190, 225, 85, 121, 154, 190, 225, 85, 121, 154, 190, 225, 85, 121, 154, 190, 229, 85, 121, 154, 225, 229, 229, 258, 303 and 336 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 85, 121, 190, 225, 229, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 258, 289, 303 and 336 225, 229, 258 and 289 225, 229, 258 and 303 225, 229, 258 and 336 225, 229, 289 and 303 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 225, 229, 289 and 336 225, 229, 303 and 336 225, 258, 289 and 303 225, 258, 289 and 336 225, 258, 303 and 336 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 225, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 85, 130, 134, 154, 190, 85, 130, 134, 154, 225, 85, 130, 134, 154, 225, 85, 130, 134, 154, 225, 85, 130, 134, 154, 225, 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 85, 130, 134, 154, 225, 85, 130, 134, 154, 229, 85, 130, 134, 190, 225, 85, 130, 134, 190, 225, 85, 130, 134, 190, 225, 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 85, 130, 134, 190, 225, 85, 130, 134, 190, 225, 85, 130, 134, 190, 229, 85, 130, 134, 225, 229, 85, 130, 154, 190, 225, 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 85, 130, 154, 190, 225, 85, 130, 154, 190, 225, 85, 130, 154, 190, 225, 85, 130, 154, 190, 225, 85, 130, 154, 190, 229, 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 85, 130, 154, 225, 229, 85, 130, 190, 225, 229, 85, 134, 154, 190, 225, 85, 134, 154, 190, 225, 85, 134, 154, 190, 225, 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 85, 134, 154, 190, 225, 85, 134, 154, 190, 225, 85, 134, 154, 190, 229, 85, 134, 154, 225, 229, 85, 134, 190, 225, 229, 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 85, 154, 190, 225, 229, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 258, 289, 303 and 336 225, 229, 258 and 289 225, 229, 258 and 303 225, 229, 258 and 336 225, 229, 289 and 303 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 225, 229, 289 and 336 225, 229, 303 and 336 225, 258, 289 and 303 225, 258, 289 and 336 225, 258, 303 and 336 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 225, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 121, 130, 134, 154, 190, 121, 130, 134, 154, 225, 121, 130, 134, 154, 225, 121, 130, 134, 154, 225, 121, 130, 134, 154, 225, 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 121, 130, 134, 154, 225, 121, 130, 134, 154, 229, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 121, 130, 134, 190, 225, 121, 130, 134, 190, 225, 121, 130, 134, 190, 229, 121, 130, 134, 225, 229, 121, 130, 154, 190, 225, 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 121, 130, 154, 190, 225, 121, 130, 154, 190, 229, 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 121, 130, 154, 225, 229, 121, 130, 190, 225, 229, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 258, 289, 303 and 336 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 121, 134, 154, 190, 225, 121, 134, 154, 190, 225, 121, 134, 154, 190, 229, 121, 134, 154, 225, 229, 121, 134, 190, 225, 229, 229, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 121, 154, 190, 225, 229, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 130, 134, 154, 190, 225, 258, 289, 303 and 336 229, 258, 289 and 303 229, 258, 289 and 336 229, 258, 303 and 336 229, 289, 303 and 336 130, 134, 154, 190, 225, 130, 134, 154, 190, 229, 130, 134, 154, 225, 229, 130, 134, 190, 225, 229, 130, 154, 190, 225, 229, 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 258, 289, 303 and 336 134, 154, 190, 225, 229, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 258, 289, 303 and 336 190, 225, 229, 258 190, 225, 229, 258 190, 225, 229, 258 190, 225, 229, 289 and 289 and 303 and 336 and 303 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 225, 229, 289 190, 225, 229, 303 190, 225, 258, 289 190, 225, 258, 289 190, 225, 258, 303 and and 336 and 336 and 303 and 336 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 225, 289, 303 190, 229, 258, 289 190, 229, 258, 289 190, 229, 258, 303 190, 229, 289, 303 and and 336 and 303 and 336 and 336 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 190, 258, 289, 303 225, 229, 258, 289 225, 229, 258, 289 225, 229, 258, 303 225, 229, 289, 303 and and 336 and 303 and 336 and 336 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 225, 258, 289, 303 229, 258, 289, 303 225, 229, 258, 289 225, 229, 258, 289 225, 229, 258, 303 and and 336 and 336 and 303 and 336 336 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 190, 85, 121, 130, 134, 225, 85, 121, 130, 154, 190, 225, 229, 289, 303 225, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 225, 229, 258, 289 and and 336 and 336 and 336 and 336 303 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 190, 85, 121, 130, 154, 225, 229, 258, 289 225, 229, 258, 303 225, 229, 289, 303 225, 258, 289, 303 190, 229, 258, 289, and 336 and 336 and 336 and 336 303 and 336 85, 121, 130, 154, 225, 85, 121, 130, 190, 225, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 229, 258, 289, 303 229, 258, 289, 303 225, 229, 258, 289 225, 229, 258, 289 190,225, 229, 258, and 336 and 336 and 303 and 336 303 and 336 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 190, 85, 121, 134, 154, 225, 85, 121, 134, 190, 225, 225, 229, 289, 303 225, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 and and 336 and 336 and 336 and 336 336 85, 121, 154, 190, 225, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 229, 258, 289, 303 225, 229, 258, 289 225, 229, 258, 289 225, 229, 258, 303 225, 229, 289, 303 and and 336 and 303 and 336 and 336 336 85, 130, 134, 154, 190, 85, 130, 134, 154, 190, 85, 130, 134, 154, 225, 85, 130, 134, 190, 225, 85, 130, 154, 190, 225, 225, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 and and 336 and 336 and 336 and 336 336 85, 134, 154, 190, 225, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 229, 258, 289, 303 225, 229, 258, 289 225, 229, 258, 289 225, 229, 258, 303 225, 229, 289, 303 and and 336 and 303 and 336 and 336 336 121, 130, 134, 154, 190, 121, 130, 134, 154, 190, 121, 130, 134, 154, 225, 121, 130, 134, 190, 225, 121, 130, 154, 190, 225, 225, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 229, 258, 289, 303 and and 336 and 336 and 336 and 336 336 121, 134, 154, 190, 225, 130, 134, 154, 190, 225, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 229, 258, 289, 303 229, 258, 289, 303 190, 225, 229, 258, 289 190, 225, 229, 258, 289 190, 225, 229, 258, 303 and 336 and 336 and 303 and 336 and 336 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 154, 85, 121, 130, 134, 190, 190, 225, 229, 289, 303 190, 225, 258, 289, 303 190, 229, 258, 289, 303 225, 229, 258, 289, 303 225, 229, 258, 289, 303 and 336 and 336 and 336 and 336 and 336 85, 121, 130, 154, 190, 85, 121, 134, 154, 190, 85, 130, 134, 154, 190, 121, 130, 134, 154, 190, 85, 121, 130, 134, 154, 225, 229, 258, 289, 303 225, 229, 258, 289, 303 225, 229, 258, 289, 303 225, 229, 258, 289, 303 190, 225, 229, 258, 289, and 336 and 336 and 336 and 336 303 and 336 60, 64, 69, 112, 115, 60, 61, 63, 64, 69, 116, 119, 120, 145, 74, 76, 85, 112, 115, 146, 198, 223, 231, 116, 119, 120, 121, 241, 251, 273, 274, 130, 134, 145, 146, 278, 303, 314, 154, 190, 198, 223, and 334 225, 227, 229, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336

[0091] In some embodiments, the polypeptide comprises a mutation as compared to SEQ ID NO: 35. In some embodiments, the mutation is a substitution, a deletion, or an insertion. In some embodiments, the mutation is a substitution. Non-limiting examples of mutations, as compared to SEQ ID NO: 35, are provided in Table 21 below.

[0092] In some embodiments, the polypeptide comprises any mutation provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises any set of mutations provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an amino acid sequence having any mutation provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an amino acid sequence having any set of mutations provided in Table 21, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 51%, at least 52%, at least 53%, at least 54%, at least 55%, at least 56%, at least 57%, at least 58%, at least 59%, at least 60%, at least 61%, at least 62%, at least 63%, at least 64%, at least 65%, at least 66%, at least 67%, at least 68%, at least 69%, at least 70%, at least 71%, at least 72%, at least 73%, at least 74%, at least 75%, at least 76%, at least 77%, at least 78%, at least 79%, at least 80%, at least 81%, at least 82%, at least 83%, at least 84%, at least 85%, at least 86%, at least 87%, at least 88%, at least 89%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the amino acid sequence comprises any mutation, or any set of mutations, provided in Table 21, as compared to SEQ ID NO: 35.

[0093] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, 1295, 1301, 1303, or 1310, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.

[0094] In some embodiments, the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. In some embodiments, a molecule comprises an Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35, wherein the polypeptide is linked or conjugated to N- or C-terminus of the Fc polypeptide.

[0095] In some embodiments, a molecule comprises an Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, 1295, 1301, 1303, or 1310, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35, wherein the polypeptide is linked or conjugated to N- or C-terminus of the Fc polypeptide.

[0096] In some embodiments, a molecule comprises an Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; and a polypeptide having an amino acid sequence of any one of SEQ ID NOs: 1290, 1295, 1301, 1303, or 1310, wherein the polypeptide is linked or conjugated to N- or C-terminus of the Fc polypeptide.

[0097] In some embodiments, a molecule comprises, from N- to C-terminus, the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290. In some embodiments, a molecule comprises, from N- to C-terminus, the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295. In some embodiments, a molecule comprises, from N- to C-terminus, the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301. In some embodiments, a molecule comprises, from N- to C-terminus, the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303. In some embodiments, a molecule comprises, from N- to C-terminus, the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310. In some embodiments, a molecule comprises, from N- to C-terminus, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23. In some embodiments, a molecule comprises, from N- to C-terminus, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23. In some embodiments, a molecule comprises, from N- to C-terminus, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23. In some embodiments, a molecule comprises, from N- to C-terminus, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23. In some embodiments, a molecule comprises, from N- to C-terminus, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23.

[0098] In some embodiments, any one mutation, or set of mutations, selected from A60T, N61D, T63I, Q64K, Q64Y, F69L, V74K, N76G, D112E, K115E, R116N, E119K, E120K, N145D, H146S, E198R, S223N, F227L, E229N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I, as compared to SEQ ID NO: 35, increases stability of the polypeptide, and reduces, or prevents anti-drug antibody binding to the polypeptide. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from A60T, N61D, T63I, Q64K, Q64Y, F69L, V74K, N76G, D112E, K115E, R116N, E119K, E120K, N145D, H146S, E198R, S223N, F227L, E229N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I, as compared to SEQ ID NO: 35, has increased stability, and/or reduced, or no binding to an anti-drug antibody.

[0099] In some embodiments, the polypeptide comprises a mutation or a set of mutations selected from any one, or any combination of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.

[0100] In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.

[0101] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 1303, 1290, 1291, 1292, 1293, 1294, 1295, 1296, 1297, 1298, 1299, 1300, 1301, 1302, 1304, 1305, 1306, 1307, 1308, 1309, 1310, and 1333, provided that the polypeptide comprises any one of, or any combination of, a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, an asparagine (N) at position 286, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and glutamine (Q) at position 336, as compared to SEQ ID NO: 35.

[0102] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, as compared to SEQ ID NO: 35.

[0103] As used herein, the language corresponds to a position, compared to a reference sequence or similar language means when the two sequences are aligned the residues line up. For example, FIG. 9 illustrates the alignment of a non-limiting polypeptide (e.g., SEQ ID NO: 1303) provided for herein to SEQ ID NO: 35 to illustrate how the positions correspond to/align with those in SEQ ID NO: 35. The alignment was done with clustal omega and default settings.

[0104] Clustal omega can be accessed, for example, at wwwdotebidotacdotuk/Tools/msa/clustalo/. Thus, in some embodiments, the mutations A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q, are as compared to SEQ ID NO: 35, which is the amino acid of wild-type full length IdeS. In some embodiments, the mutations are as compared to the polypeptides disclosed herein, which may be variants and/or truncations of the wild-type full-length IdeS having the amino acid sequence of SEQ ID NO: 35. In some embodiments, the mutations A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q, as compared to SEQ ID NO: 35, may be provided as A13T, N14T, T16I, Q17Y, F22L, V27K, N29G, T38L, D65E, K68E, R69N, E72K, E73K, H74Y, N83K, N83G, M87L, N98D, H99S, E107D, N143D, E151R, S176N, H178Y, F180L, N184T, K194Q, L204I, V211G, N214G, S226A, N227E, K231E, D239N, A242P, A256S, K267E, S287I, and N289Q, as compared to, for example, SEQ ID NO: 1303, respectively. Thus, in some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations of A13T, N14T, T16I, Q17Y, F22L, V27K, N29G, T38L, D65E, K68E, R69N, E72K, E73K, H74Y, N83K, N83G, M87L, N98D, H99S, E107D, N143D, E151R, S176N, H178Y, F180L, N184T, K194Q, L204I, V211G, N214G, S226A, N227E, K231E, D239N, A242P, A256S, K267E, S287I, and N289Q, as compared to, SEQ ID NO: 1303.

[0105] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises a threonine (T) at position 13, an aspartic acid (D) at position 14, an isoleucine (I) at position 16, a tyrosine (Y) at position 17, a leucine (L) at position 22, a lysine (K) at position 27, a glycine (G) at position 29, a leucine (L) at position 38, a glutamic acid (E) at position 65, an asparagine (N) at position 69, a lysine (K) at position 72, a lysine (K) at position 73, a tyrosine (Y) at position 74, a glycine (G) at position 83, a leucine (L) at position 87, an aspartic acid (D) at position 98, a serine (S) at position 99, an aspartic acid (D) at position 107, an aspartic acid (D) at position 143, an arginine (R) at position 151, an asparagine (N) at position 176, a tyrosine (Y) at position 178, a leucine (L) at position 180, a threonine (T) at position 184, a glutamine (Q) at position 194, an isoleucine (I) at position 204, a glycine (G) at position 214, an alanine (A) at position 226, a glutamic acid (E) at position 227, a glutamic acid (E) at position 231, a proline (P) at position 242, a serine (S) at position 256, a glutamic acid (E) at position 267, and an isoleucine (I) at position 287, as compared to SEQ ID NO: 1303.

[0106] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 1290, 1291, 1292, 1293, 1294, 1295, 1296, 1297, 1298, 1299, 1300, 1301, 1302, 1304, 1305, 1306, 1307, 1308, 1309, 1310, and 1333, provided that the polypeptide comprises any one of sets selected from: a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 258, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, an asparagine (N) at position 286, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, as compared to SEQ ID NO: 35; or a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336 as compared to SEQ ID NO: 35.

[0107] In some embodiments, a polypeptide comprises any one of sets selected from: a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 258, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, an asparagine (N) at position 286, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, as compared to SEQ ID NO: 35; or a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336 as compared to SEQ ID NO: 35.

[0108] In some embodiments, a polypeptide is provided that is at least 50%, 60%, 70%, 75%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, provided that the polypeptide comprises one or more of, or all of the following: a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, wherein the positions correspond to the positions as in SEQ ID NO: 35. In some embodiments, the polypeptide is at least 80% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 81% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 82% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 83% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 84% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 85% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 86% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 87% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 88% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 89% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide is at least 90% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, with the provisos described in this paragraph. In some embodiments, the polypeptide does not comprises the amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351). In some embodiments, the polypeptide does not include the amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351). In some embodiments, the polypeptide does not include the contiguous amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351) in its entirety. In some embodiments, the polypeptide does not include the contiguous amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351) in its entirety, or the dipeptide of VT at the N-terminus of the polypeptide. As used herein, the N-terminus of the polypeptide in reference to the contiguous amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351), or the dipeptide of VT means the N-terminus of the protease, which may be C-terminal to a linker or another polypeptide if the protease is linked to another polypeptide, such as the Fc domains provided for herein. In some embodiments, the polypeptide does not include the dipeptide of VT at the N-terminus of the polypeptide. In some embodiments, the polypeptide does not comprises the amino acid sequence of DSFSANQEIRYSEVTPYH (SEQ ID NO: 1352). In some embodiments, the polypeptide does not comprises the amino acid sequence of ANQEIRYSEVTPYHVT (SEQ ID NO: 1353).

[0109] In some embodiments, the polypeptide does not comprises the amino acid sequence of ANQEIRYSEVTPYH (SEQ ID NO: 1354). In some embodiments, the polypeptide does not comprise the amino acid sequence of NQTN (SEQ ID NO: 1355). In some embodiments, the polypeptide does not comprise the contiguous amino acid sequence of NQTN (SEQ ID NO: 1355). In some embodiments, the polypeptide does not comprise the contiguous amino acid sequence of NQTN (SEQ ID NO: 1355) at the C-terminus of the polypeptide. As used herein, the C-terminus of the polypeptide in reference to the contiguous amino acid sequence of NQTN (SEQ ID NO: 1355) means the C-terminus of the protease, which may be N-terminal to a linker or another polypeptide if the protease is linked to another polypeptide, such as the Fc domains provided for herein. In some embodiments, the polypeptide comprises the sequence of QQTN (SEQ ID NO: 1356) at the C-terminus of the polypeptide instead of the sequence of NQTN (SEQ ID NO: 1355).

[0110] In some embodiments, the polypeptide has a cysteine (C) at the position in said polypeptide which corresponds to position 94 of SEQ ID NO: 35. In some embodiments, the polypeptide has, at the positions in said variant sequence which correspond to positions 84, 262, 284 and 286 of SEQ ID NO: 35, a lysine (K), a histidine (H), an aspartic acid (D) and an aspartic acid (D), respectively. In some embodiments, the polypeptide has Ig protease activity. In some embodiments, the polypeptide has IgG protease activity. In some embodiments, the polypeptide is wherein is less immunogenic than an IdeS polypeptide, such as an IdeS polypeptide that comprises the amino acid sequence of SEQ ID NO: 35, SEQ ID NO: 36 or SEQ ID NO: 1349. In some embodiments, the polypeptide produces greater quantity of IgG cleavage fragments than IdeS (e.g., SEQ ID NO: 35, SEQ ID NO: 36, or SEQ ID NO: 1349). In some embodiments, the polypeptide has a positively charged amino acid at the position in said variant which corresponds to position 130 of SEQ ID NO: 35, such as, arginine (R) or lysine (K). In some embodiments, the polypeptide has a positively charged amino acid at the position in said variant which corresponds to position 131 of SEQ ID NO: 35, such as arginine (R) or lysine (K).

[0111] In some embodiments, the polypeptide is linked to a protease resistant Fc domain. In some embodiments, the protease resistant Fc domain is linked to the N-terminus or the C-terminus of the polypeptide. In some embodiments, the protease resistant Fc domain is linked to the N-terminus of the polypeptide. In some embodiments, the protease resistant Fc domain is linked to the C-terminus of the polypeptide. In some embodiments, the protease resistant Fc domain is linked to the polypeptide through a linker. In some embodiments, the protease resistant Fc domain is linked to the polypeptide through a peptide linker. In some embodiments, the peptide linker is a charged peptide linker. As used herein, charged peptide linker is meant to refer to a peptide linker having at least one positively charged amino acid residue, such as, but not limited to, a lysine (K), an arginine (R), or a histidine (H). In some embodiments, the peptide linker comprises the amino acid sequence of SEQ ID NO: 1330. In some embodiments, the protease resistant Fc domain is as provided for herein. In some embodiments, the protease resistant Fc domain comprises the amino acid sequence of any one of SEQ ID NOs: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49. In some embodiments, the protease resistant Fc domain comprises the amino acid sequence of SEQ ID NO: 23. In some embodiments, the polypeptide comprises a polypeptide from N-terminus to C-terminus a protease resistant Fc domain, a peptide linker, and a polypeptide, wherein the C-terminus of the protease resistant Fc domain is linked to the N-terminus of the peptide linker and the C-terminus of the peptide linker is linked to the N-terminus of the polypeptide.

[0112] In some embodiments, the polypeptide comprises the amino acid sequence as set forth in Table 7 in the column labeled Full length sequence of VRT-1 through VRT-319. In some embodiments, the polypeptide has Ig protease activity, such as IgG protease activity. In some embodiments, the polypeptide is less immunogenic than an IdeS polypeptide, wherein the IdeS polypeptide optionally comprises the amino acid sequence of SEQ ID NO: 35, SEQ ID NO: 36 or SEQ ID NO: 1349. In some embodiments, the polypeptide produces greater quantity of IgG cleavage fragments than IdeS (e.g., SEQ ID NO: 35, SEQ ID NO: 36, or SEQ ID NO: 1349). In some embodiments, the polypeptide of SEQ ID NO: 1349 produces greater quantity of IgG cleavage fragments than IdeS.

[0113] In some embodiments, a mutation of H225Y, as compared to SEQ ID NO: 35, increases expression of the polypeptide. In some embodiments, the polypeptide comprising a mutation of H225Y, as compared to SEQ ID NO: 35, has increased expression. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, E154D, N190D, A289P, and N303S, as compared to SEQ ID NO: 35, removes the T-cell binding epitope. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, E154D, N190D, A289P, and N303S, as compared to SEQ ID NO: 35, reduces, or prevents T-cell binding to the polypeptide. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, E154D, N190D, A289P, and N303S, as compared to SEQ ID NO: 35, has no T-cell binding epitope. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, E154D, N190D, A289P, and N303S, as compared to SEQ ID NO: 35, does not bind to a T-cell. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, E154D, N190D, A289P, and N303S, as compared to SEQ ID NO: 35, removes the T-cell binding epitope. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, E154D, N190D, A289P, and N303S, as compared to SEQ ID NO: 35, reduces, or prevents T-cell binding to the polypeptide. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, E154D, N190D, V258G, A289P, and N303S, as compared to SEQ ID NO: 35, has no T-cell binding epitope. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, E154D, N190D, V258G, A289P, and N303S, as compared to SEQ ID NO: 35, does not bind to a T-cell.

[0114] In some embodiments, any one mutation, or set of mutations, selected from M134L, N190D, N229E, A289P, and N336Q, as compared to SEQ ID NO: 35, removes the chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from M134L, N190D, N229E, A289P, and N336Q, as compared to SEQ ID NO: 35, has no chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from N130K, M134L, N190D, N229E, A289P, and N336Q, as compared to SEQ ID NO: 35, removes the chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from N130K, M134L, N190D, N229E, A289P, and N336Q, as compared to SEQ ID NO: 35, has no chemical liabilities.

[0115] In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, removes the T-cell binding epitope, and removes the chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, reduces, or prevents T-cell binding to the polypeptide, and/or removes the chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, does not bind to a T-cell, and/or has no chemical liabilities.

[0116] In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, removes the T-cell binding epitope, and removes the chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, reduces, or prevents T-cell binding to the polypeptide, and/or removes the chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, does not bind to a T-cell, and/or has no chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, removes the T-cell binding epitope, and removes the chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, reduces, or prevents T-cell binding to the polypeptide, and/or removes the chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, N130K, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, does not bind to a T-cell, and/or has no chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, removes the T-cell binding epitope, and removes the chemical liabilities. In some embodiments, any one mutation, or set of mutations, selected from T85L, H121Y, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, increases stability of the polypeptide, reduces, or prevents anti-drug antibody binding to the polypeptide, reduces, or prevents T-cell binding to the polypeptide, and/or removes the chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities. In some embodiments, the polypeptide comprising any one, or any set, of mutations selected from T85L, H121Y, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, as compared to SEQ ID NO: 35, has increased stability, reduced, or no binding to an anti-drug antibody, does not bind to a T-cell, and/or has no chemical liabilities.

TABLE-US-00010 TABLE 21 Non-limiting examples of mutations [as compared to SEQ ID NO: 35] A60T N61D T63I Q64K V74K N76G H146S F227L E229NT85L H121Y N130K M134L E154D N190D H225Y N229E V258G A289P N303S N336Q T85L and H121Y T85L and N130K T85L and M134L T85L and E154D T85L and N190D T85L and H225Y T85L and N229E T85L and V258G T85L and A289P T85L and N303S T85L and N336Q H121Y and N130K H121Y and M134L H121Y and E154D H121Y and N190D H121Y and H225Y H121Y and N229E H121Y and V258G H121Y and A289P H121Y and N303S H121Y and N336Q N130K and M134L N130K and E154D N130K and N190D N130K and H225Y N130K and N229E N130K and V258G N130K and A289P N130K and N303S N130K and N336Q M134L and E154D M134L and N190D M134L and H225Y M134L and N229E M134L and V258G M134L and A289P M134L and N303S M134L and N336Q E154D and N190D E154D and H225Y E154D and N229E E154D and V258G E154D and A289P E154D and N303S E154D and N336Q N190D and H225Y N190D and N229E N190D and V258G N190D and A289P N190D and N303S N190D and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q A60T and N61D A60T and T63I A60T and Q64K A60T and V74K A60T and N76G A60T and H146S A60T and F227L A60T and E229N N61D and T63I N61D and Q64K N61D and V74K N61D and N76G N61D and H146S N61D and F227L N61D and E229N T63I and Q64K T63I and V74K T63I and N76G T63I and H146S T63I and F227L T63I and E229N Q64K and V74K Q64K and N76G Q64K and H146S Q64K and F227L Q64K and E229N V74K and N76G V74K and H146S V74K and F227L V74K and E229N N76G and H146S N76G and F227L N76G and E229N H146S and F227L H146S and E229N F227L and E229N A60T, N61D and T63I A60T, N61D and Q64K A60T, N61D and V74K A60T, N61D and N76G A60T, N61D and H146S A60T, N61D and F227L A60T, N61D and E229N A60T, T63I and Q64K A60T, T63I and V74K A60T, T63I and N76G A60T, T63I and H146S A60T, T63I and F227L A60T, T63I and E229N A60T, Q64K and V74K A60T, Q64K and N76G A60T, Q64K and H146S A60T, Q64K and F227L A60T, Q64K and E229N A60T, V74K and N76G A60T, V74K and H146S A60T, V74K and F227L A60T, V74K and E229N A60T, N76G and H146S A60T, N76G and F227L A60T, N76G and E229N A60T, H146S and F227L A60T, H146S and E229N A60T, F227L and E229N N61D, T63I and Q64K N61D, T63I and V74K N61D, T63I and N76G N61D, T63I and H146S N61D, T63I and F227L N61D, T63I and E229N N61D, Q64K and V74K N61D, Q64K and N76G N61D, Q64K and H146S N61D, Q64K and F227L N61D, Q64K and E229N N61D, V74K and N76G N61D, V74K and H146S N61D, V74K and F227L N61D, V74K and E229N N61D, N76G and H146S N61D, N76G and F227L N61D, N76G and E229N N61D, H146S and F227L N61D, H146S and E229N N61D, F227L and E229N T63I, Q64K and V74K T63I, Q64K and N76G T63I, Q64K and H146S T63I, Q64K and F227L T63I, Q64K and E229N T63I, V74K and N76G T63I, V74K and H146S T63I, V74K and F227L T63I, V74K and E229N T63I, N76G and H146S T63I, N76G and F227L T63I, N76G and E229N T63I, H146S and F227L T63I, H146S and E229N T63I, F227L and E229N Q64K, V74K and N76G Q64K, V74K and H146S Q64K, V74K and F227L Q64K, V74K and E229N Q64K, N76G and H146S Q64K, N76G and F227L Q64K, N76G and E229N Q64K, H146S and F227L Q64K, H146S and E229N Q64K, F227L and E229N V74K, N76G and H146S V74K, N76G and F227L V74K, N76G and E229N V74K, H146S and F227L V74K, H146S and E229N V74K, F227L and E229N N76G, H146S and F227L N76G, H146S and E229N N76G, F227L and E229N H146S, F227L and T85L, H121Y and M134L T85L, H121Y and E154D T85L, H121Y and N190D T85L, H121Y and H225Y E229NT85L, H121Y and N130K T85L, H121Y and N229E T85L, H121Y and V258G T85L, H121Y and A289P T85L, H121Y and N303S T85L, H121Y and N336Q T85L, N130K and M134L T85L, N130K and E154D T85L, N130K and N190D T85L, N130K and H225Y T85L, N130K and N229E T85L, N130K and V258G T85L, N130K and A289P T85L, N130K and N303S T85L, N130K and N336Q T85L, M134L and E154D T85L, M134L and N190D T85L, M134L and H225Y T85L, M134L and N229E T85L, M134L and V258G T85L, M134L and A289P T85L, M134L and N303S T85L, M134L and N336Q T85L, E154D and N190D T85L, E154D and H225Y T85L, E154D and N229E T85L, E154D and V258G T85L, E154D and A289P T85L, E154D and N303S T85L, E154D and N336Q T85L, N190D and H225Y T85L, N190D and N229E T85L, N190D and V258G T85L, N190D and A289P T85L, N190D and N303S T85L, N190D and N336Q T85L, H225Y and N229E T85L, H225Y and V258G T85L, H225Y and A289P T85L, H225Y and N303S T85L, H225Y and N336Q T85L, N229E and V258G T85L, N229E and A289P T85L, N229E and N303S T85L, N229E and N336Q T85L, V258G and A289P T85L, V258G and N303S T85L, V258G and N336Q T85L, A289P and N303S T85L, A289P and N336Q T85L, N303S and N336Q H121Y, N130K and M134L H121Y, N130K and H121Y, N130K and H121Y, N130K and H225Y H121Y, N130K and E154D N190D N229E H121Y, N130K and V258G H121Y, N130K and H121Y, N130K and H121Y, N130K and N336Q H121Y, M134L and A289P N303S E154D H121Y, M134L and N190D H121Y, M134L and H121Y, M134L and H121Y, M134L and H121Y, M134L and H225Y N229E V258G A289P H121Y, M134L and N303S H121Y, M134L and H121Y, E154D and H121Y, E154D and H225Y H121Y, E154D and N336Q N190D N229E H121Y, E154D and V258G H121Y, E154D and H121Y, E154D and H121Y, E154D and N336Q H121Y, N190D and A289P N303S H225Y H121Y, N190D and N229E H121Y, N190D and H121Y, N190D and H121Y, N190D and N303S H121Y, N190D and V258G A289P N336Q H121Y, H225Y and N229E H121Y, H225Y and H121Y, H225Y and H121Y, H225Y and N303S H121Y, H225Y and V258G A289P N336Q H121Y, N229E and V258G H121Y, N229E and H121Y, N229E and H121Y, N229E and N336Q H121Y, V258G and A289P N303S A289P H121Y, V258G and N303S H121Y, V258G and H121Y, A289P and H121Y, A289P and N336Q H121Y, N303S and N336Q N303S N336Q N130K, M134L and E154D N130K, M134L and N130K, M134L and N130K, M134L and N229E N130K, M134L and N190D H225Y V258G N130K, M134L and A289P N130K, M134L and N130K, M134L and N130K, E154D and N190D N130K, E154D and N303S N336Q H225Y N130K, E154D and N229E N130K, E154D and N130K, E154D and N130K, E154D and N303S N130K, E154D and V258G A289P N336Q N130K, N190D and H225Y N130K, N190D and N130K, N190D and N130K, N190D and A289P N130K, N190D and N229E V258G N303S N130K, N190D and N336Q N130K, H225Y and N130K, H225Y and N130K, H225Y and A289P N130K, H225Y and N229E V258G N303S N130K, H225Y and N336Q N130K, N229E and N130K, N229E and N130K, N229E and N303S N130K, N229E and V258G A289P N336Q N130K, V258G and A289P N130K, V258G and N130K, V258G and N130K, A289P and N303S N130K, A289P and N303S N336Q N336Q N130K, N303S and N336Q M134L, E154D and M134L, E154D and M134L, E154D and N229E M134L, E154D and N190D H225Y V258G M134L, E154D and A289P M134L, E154D and M134L, E154D and M134L, N190D and M134L, N190D and N303S N336Q H225Y N229E M134L, N190D and V258G M134L, N190D and M134L, N190D and M134L, N190D and M134L, H225Y and A289P N303S N336Q N229E M134L, H225Y and V258G M134L, H225Y and M134L, H225Y and M134L, H225Y and M134L, N229E and A289P N303S N336Q V258G M134L, N229E and A289P M134L, N229E and M134L, N229E and M134L, V258G and A289P M134L, V258G and N303S N336Q N303S M134L, V258G and N336Q M134L, A289P and M134L, A289P and M134L, N303S and N336Q E154D, N190D and N303S N336Q H225Y E154D, N190D and N229E E154D, N190D and E154D, N190D and E154D, N190D and N303S E154D, N190D and V258G A289P N336Q E154D, H225Y and N229E E154D, H225Y and E154D, H225Y and E154D, H225Y and N303S E154D, H225Y and V258G A289P N336Q E154D, N229E and V258G E154D, N229E and E154D, N229E and E154D, N229E and N336Q E154D, V258G and A289P N303S A289P E154D, V258G and N303S E154D, V258G and E154D, A289P and E154D, A289P and N336Q E154D, N303S and N336Q N303S N336Q N190D, H225Y and N229E N190D, H225Y and N190D, H225Y and N190D, H225Y and N303S N190D, H225Y and V258G A289P N336Q N190D, N229E and V258G N190D, N229E and N190D, N229E and N190D, N229E and N336Q N190D, V258G and A289P N303S A289P N190D, V258G and N303S N190D, V258G and N190D, A289P and N190D, A289P and N336Q N190D, N303S and N336Q N303S N336Q H225Y, N229E and V258G H225Y, N229E and H225Y, N229E and H225Y, N229E and N336Q H225Y, V258G and A289P N303S A289P H225Y, V258G and N303S H225Y, V258G and H225Y, A289P and H225Y, A289P and N336Q H225Y, N303S and N336Q N303S N336Q N229E, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, N130K and T85L, H121Y, N130K T85L, H121Y, N130K T85L, H121Y, N130K and T85L, H121Y, N130K M134L and E154D and N190D H225Y and N229E T85L, H121Y, N130K and T85L, H121Y, N130K T85L, H121Y, N130K T85L, H121Y, N130K and T85L, H121Y, M134L V258G and A289P and N303S N336Q and E154D T85L, H121Y, M134L and T85L, H121Y, M134L T85L, H121Y, M134L T85L, H121Y, M134L and T85L, H121Y, M134L N190D and H225Y and N229E V258G and A289P T85L, H121Y, M134L and T85L, H121Y, M134L T85L, H121Y, E154D and T85L, H121Y, E154D and T85L, H121Y, E154D and N303S and N336Q N190D H225Y N229E T85L, H121Y, E154D and T85L, H121Y, E154D and T85L, H121Y, E154D and T85L, H121Y, E154D and T85L, H121Y, N190D V258G A289P N303S N336Q and H225Y T85L, H121Y, N190D and T85L, H121Y, N190D T85L, H121Y, N190D T85L, H121Y, N190D and T85L, H121Y, N190D N229E and V258G and A289P N303S and N336Q T85L, H121Y, H225Y and T85L, H121Y, H225Y T85L, H121Y, H225Y T85L, H121Y, H225Y and T85L, H121Y, H225Y N229E and V258G and A289P N303S and N336Q T85L, H121Y, N229E and T85L, H121Y, N229E and T85L, H121Y, N229E and T85L, H121Y, N229E and T85L, H121Y, V258G V258G A289P N303S N336Q and A289P T85L, H121Y, V258G and T85L, H121Y, V258G T85L, H121Y, A289P and T85L, H121Y, A289P and T85L, H121Y, N303S and N303S and N336Q N303S N336Q N336Q T85L, N130K, M134L and T85L, N130K, M134L T85L, N130K, M134L T85L, N130K, M134L and T85L, N130K, M134L E154D and N190D and H225Y N229E and V258G T85L, N130K, M134L and T85L, N130K, M134L T85L, N130K, M134L T85L, N130K, E154D and T85L, N130K, E154D and A289P and N303S and N336Q N190D H225Y T85L, N130K, E154D and T85L, N130K, E154D and T85L, N130K, E154D and T85L, N130K, E154D and T85L, N130K, E154D and N229E V258G A289P N303S N336Q T85L, N130K, N190D and T85L, N130K, N190D T85L, N130K, N190D T85L, N130K, N190D and T85L, N130K, N190D H225Y and N229E and V258G A289P and N303S T85L, N130K, N190D and T85L, N130K, H225Y T85L, N130K, H225Y T85L, N130K, H225Y and T85L, N130K, H225Y N336Q and N229E and V258G A289P and N303S T85L, N130K, H225Y and T85L, N130K, N229E and T85L, N130K, N229E and T85L, N130K, N229E and T85L, N130K, N229E and N336Q V258G A289P N303S N336Q T85L, N130K, V258G and T85L, N130K, V258G T85L, N130K, V258G T85L, N130K, A289P and T85L, N130K, A289P and A289P and N303S and N336Q N303S N336Q T85L, N130K, N303S and T85L, M134L, E154D and T85L, M134L, E154D and T85L, M134L, E154D and T85L, M134L, E154D and N336Q N190D H225Y N229E V258G T85L, M134L, E154D and T85L, M134L, E154D and T85L, M134L, E154D and T85L, M134L, N190D and T85L, M134L, N190D A289P N303S N336Q H225Y and N229E T85L, M134L, N190D and T85L, M134L, N190D T85L, M134L, N190D T85L, M134L, N190D and T85L, M134L, H225Y V258G and A289P and N303S N336Q and N229E T85L, M134L, H225Y and T85L, M134L, H225Y T85L, M134L, H225Y T85L, M134L, H225Y and T85L, M134L, N229E and V258G and A289P and N303S N336Q V258G T85L, M134L, N229E and T85L, M134L, N229E and T85L, M134L, N229E and T85L, M134L, V258G and T85L, M134L, V258G A289P N303S N336Q A289P and N303S T85L, M134L, V258G and T85L, M134L, A289P and T85L, M134L, A289P and T85L, M134L, N303S and T85L, E154D, N190D and N336Q N303S N336Q N336Q H225Y T85L, E154D, N190D and T85L, E154D, N190D and T85L, E154D, N190D and T85L, E154D, N190D and T85L, E154D, N190D and N229E V258G A289P N303S N336Q T85L, E154D, H225Y and T85L, E154D, H225Y and T85L, E154D, H225Y and T85L, E154D, H225Y and T85L, E154D, H225Y and N229E V258G A289P N303S N336Q T85L, E154D, N229E and T85L, E154D, N229E and T85L, E154D, N229E and T85L, E154D, N229E and T85L, E154D, V258G and V258G A289P N303S N336Q A289P T85L, E154D, V258G and T85L, E154D, V258G and T85L, E154D, A289P and T85L, E154D, A289P and T85L, E154D, N303S and N303S N336Q N303S N336Q N336Q T85L, N190D, H225Y and T85L, N190D, H225Y T85L, N190D, H225Y T85L, N190D, H225Y and T85L, N190D, H225Y N229E and V258G and A289P N303S and N336Q T85L, N190D, N229E and T85L, N190D, N229E and T85L, N190D, N229E and T85L, N190D, N229E and T85L, N190D, V258G V258G A289P N303S N336Q and A289P T85L, N190D, V258G and T85L, N190D, V258G T85L, N190D, A289P and T85L, N190D, A289P and T85L, N190D, N303S and N303S and N336Q N303S N336Q N336Q T85L, H225Y, N229E and T85L, H225Y, N229E and T85L, H225Y, N229E and T85L, H225Y, N229E and T85L, H225Y, V258G V258G A289P N303S N336Q and A289P T85L, H225Y, V258G and T85L, H225Y, V258G T85L, H225Y, A289P and T85L, H225Y, A289P and T85L, H225Y, N303S and N303S and N336Q N303S N336Q N336Q T85L, N229E, V258G and T85L, N229E, V258G and T85L, N229E, V258G and T85L, N229E, A289P and T85L, N229E, A289P and A289P N303S N336Q N303S N336Q T85L, N229E, N303S and T85L, V258G, A289P and T85L, V258G, A289P and T85L, V258G, N303S and T85L, A289P, N303S and N336Q N303S N336Q N336Q N336Q H121Y, N130K, M134L and H121Y, N130K, M134L H121Y, N130K, M134L H121Y, N130K, M134L H121Y, N130K, M134L E154D and N190D and H225Y and N229E and V258G H121Y, N130K, M134L and H121Y, N130K, M134L H121Y, N130K, M134L H121Y, N130K, E154D H121Y, N130K, E154D A289P and N303S and N336Q and N190D and H225Y H121Y, N130K, E154D and H121Y, N130K, E154D H121Y, N130K, E154D H121Y, N130K, E154D H121Y, N130K, E154D N229E and V258G and A289P and N303S and N336Q H121Y, N130K, N190D and H121Y, N130K, N190D H121Y, N130K, N190D H121Y, N130K, N190D H121Y, N130K, N190D H225Y and N229E and V258G and A289P and N303S H121Y, N130K, N190D and H121Y, N130K, H225Y H121Y, N130K, H225Y H121Y, N130K, H225Y H121Y, N130K, H225Y N336Q and N229E and V258G and A289P and N303S H121Y, N130K, H225Y and H121Y, N130K, N229E H121Y, N130K, N229E H121Y, N130K, N229E H121Y, N130K, N229E N336Q and V258G and A289P and N303S and N336Q H121Y, N130K, V258G and H121Y, N130K, V258G H121Y, N130K, V258G H121Y, N130K, A289P H121Y, N130K, A289P A289P and N303S and N336Q and N303S and N336Q H121Y, N130K, N303S and H121Y, M134L, E154D H121Y, M134L, E154D H121Y, M134L, E154D H121Y, M134L, E154D N336Q and N190D and H225Y and N229E and V258G H121Y, M134L, E154D and H121Y, M134L, E154D H121Y, M134L, E154D H121Y, M134L, N190D H121Y, M134L, N190D A289P and N303S and N336Q and H225Y and N229E H121Y, M134L, N190D and H121Y, M134L, N190D H121Y, M134L, N190D H121Y, M134L, N190D H121Y, M134L, H225Y V258G and A289P and N303S and N336Q and N229E H121Y, M134L, H225Y and H121Y, M134L, H225Y H121Y, M134L, H225Y H121Y, M134L, H225Y H121Y, M134L, N229E V258G and A289P and N303S and N336Q and V258G H121Y, M134L, N229E and H121Y, M134L, N229E H121Y, M134L, N229E H121Y, M134L, V258G H121Y, M134L, V258G A289P and N303S and N336Q and A289P and N303S H121Y, M134L, V258G and H121Y, M134L, A289P H121Y, M134L, A289P H121Y, M134L, N303S H121Y, E154D, N190D N336Q and N303S and N336Q and N336Q and H225Y H121Y, E154D, N190D and H121Y, E154D, N190D H121Y, E154D, N190D H121Y, E154D, N190D H121Y, E154D, N190D N229E and V258G and A289P and N303S and N336Q H121Y, E154D, H225Y and H121Y, E154D, H225Y H121Y, E154D, H225Y H121Y, E154D, H225Y H121Y, E154D, H225Y N229E and V258G and A289P and N303S and N336Q H121Y, E154D, N229E and H121Y, E154D, N229E H121Y, E154D, N229E H121Y, E154D, N229E H121Y, E154D, V258G V258G and A289P and N303S and N336Q and A289P H121Y, E154D, V258G and H121Y, E154D, V258G H121Y, E154D, A289P H121Y, E154D, A289P and H121Y, E154D, N303S N303S and N336Q and N303S N336Q and N336Q H121Y, N190D, H225Y and H121Y, N190D, H225Y H121Y, N190D, H225Y H121Y, N190D, H225Y H121Y, N190D, H225Y N229E and V258G and A289P and N303S and N336Q H121Y, N190D, N229E and H121Y, N190D, N229E H121Y, N190D, N229E H121Y, N190D, N229E H121Y, N190D, V258G V258G and A289P and N303S and N336Q and A289P H121Y, N190D, V258G and H121Y, N190D, V258G H121Y, N190D, A289P H121Y, N190D, A289P H121Y, N190D, N303S N303S and N336Q and N303S and N336Q and N336Q H121Y, H225Y, N229E and H121Y, H225Y, N229E H121Y, H225Y, N229E H121Y, H225Y, N229E H121Y, H225Y, V258G V258G and A289P and N303S and N336Q and A289P H121Y, H225Y, V258G and H121Y, H225Y, V258G H121Y, H225Y, A289P H121Y, H225Y, A289P H121Y, H225Y, N303S N303S and N336Q and N303S and N336Q and N336Q H121Y, N229E, V258G and H121Y, N229E, V258G H121Y, N229E, V258G H121Y, N229E, A289P and H121Y, N229E, A289P A289P and N303S and N336Q N303S and N336Q H121Y, N229E, N303S and H121Y, V258G, A289P H121Y, V258G, A289P H121Y, V258G, N303S H121Y, A289P, N303S N336Q and N303S and N336Q and N336Q and N336Q N130K, M134L, E154D and N130K, M134L, E154D N130K, M134L, E154D N130K, M134L, E154D N130K, M134L, E154D N190D and H225Y and N229E and V258G and A289P N130K, M134L, E154D and N130K, M134L, E154D N130K, M134L, N190D N130K, M134L, N190D N130K, M134L, N190D N303S and N336Q and H225Y and N229E and V258G N130K, M134L, N190D and N130K, M134L, N190D N130K, M134L, N190D N130K, M134L, H225Y N130K, M134L, H225Y A289P and N303S and N336Q and N229E and V258G N130K, M134L, H225Y and N130K, M134L, H225Y N130K, M134L, H225Y N130K, M134L, N229E N130K, M134L, N229E A289P and N303S and N336Q and V258G and A289P N130K, M134L, N229E and N130K, M134L, N229E N130K, M134L, V258G N130K, M134L, V258G N130K, M134L, V258G N303S and N336Q and A289P and N303S and N336Q N130K, M134L, A289P and N130K, M134L, A289P N130K, M134L, N303S N130K, E154D, N190D N130K, E154D, N190D N303S and N336Q and N336Q and H225Y and N229E N130K, E154D, N190D and N130K, E154D, N190D N130K, E154D, N190D N130K, E154D, N190D N130K, E154D, H225Y V258G and A289P and N303S and N336Q and N229E N130K, E154D, H225Y and N130K, E154D, H225Y N130K, E154D, H225Y N130K, E154D, H225Y N130K, E154D, N229E V258G and A289P and N303S and N336Q and V258G N130K, E154D, N229E and N130K, E154D, N229E N130K, E154D, N229E N130K, E154D, V258G N130K, E154D, V258G A289P and N303S and N336Q and A289P and N303S N130K, E154D, V258G and N130K, E154D, A289P N130K, E154D, A289P N130K, E154D, N303S and N130K, N190D, H225Y N336Q and N303S and N336Q N336Q and N229E N130K, N190D, H225Y and N130K, N190D, H225Y N130K, N190D, H225Y N130K, N190D, H225Y N130K, N190D, N229E V258G and A289P and N303S and N336Q and V258G N130K, N190D, N229E and N130K, N190D, N229E N130K, N190D, N229E N130K, N190D, V258G N130K, N190D, V258G A289P and N303S and N336Q and A289P and N303S N130K, N190D, V258G and N130K, N190D, A289P N130K, N190D, A289P N130K, N190D, N303S N130K, H225Y, N229E N336Q and N303S and N336Q and N336Q and V258G N130K, H225Y, N229E and N130K, H225Y, N229E N130K, H225Y, N229E N130K, H225Y, V258G N130K, H225Y, V258G A289P and N303S and N336Q and A289P and N303S N130K, H225Y, V258G and N130K, H225Y, A289P N130K, H225Y, A289P N130K, H225Y, N303S N130K, N229E, V258G N336Q and N303S and N336Q and N336Q and A289P N130K, N229E, V258G and N130K, N229E, V258G N130K, N229E, A289P N130K, N229E, A289P and N130K, N229E, N303S N303S and N336Q and N303S N336Q and N336Q N130K, V258G, A289P and N130K, V258G, A289P N130K, V258G, N303S N130K, A289P, N303S and M134L, E154D, N190D N303S and N336Q and N336Q N336Q and H225Y M134L, E154D, N190D and M134L, E154D, N190D M134L, E154D, N190D M134L, E154D, N190D M134L, E154D, N190D N229E and V258G and A289P and N303S and N336Q M134L, E154D, H225Y and M134L, E154D, H225Y M134L, E154D, H225Y M134L, E154D, H225Y M134L, E154D, H225Y N229E and V258G and A289P and N303S and N336Q M134L, E154D, N229E and M134L, E154D, N229E M134L, E154D, N229E M134L, E154D, N229E M134L, E154D, V258G V258G and A289P and N303S and N336Q and A289P M134L, E154D, V258G and M134L, E154D, V258G M134L, E154D, A289P M134L, E154D, A289P M134L, E154D, N303S N303S and N336Q and N303S and N336Q and N336Q M134L, N190D, H225Y and M134L, N190D, H225Y M134L, N190D, H225Y M134L, N190D, H225Y M134L, N190D, H225Y N229E and V258G and A289P and N303S and N336Q M134L, N190D, N229E and M134L, N190D, N229E M134L, N190D, N229E M134L, N190D, N229E M134L, N190D, V258G V258G and A289P and N303S and N336Q and A289P M134L, N190D, V258G and M134L, N190D, V258G M134L, N190D, A289P M134L, N190D, A289P M134L, N190D, N303S N303S and N336Q and N303S and N336Q and N336Q M134L, H225Y, N229E and M134L, H225Y, N229E M134L, H225Y, N229E M134L, H225Y, N229E M134L, H225Y, V258G V258G and A289P and N303S and N336Q and A289P M134L, H225Y, V258G and M134L, H225Y, V258G M134L, H225Y, A289P M134L, H225Y, A289P M134L, H225Y, N303S N303S and N336Q and N303S and N336Q and N336Q M134L, N229E, V258G and M134L, N229E, V258G M134L, N229E, V258G M134L, N229E, A289P M134L, N229E, A289P A289P and N303S and N336Q and N303S and N336Q M134L, N229E, N303S and M134L, V258G, A289P M134L, V258G, A289P M134L, V258G, N303S M134L, A289P, N303S N336Q and N303S and N336Q and N336Q and N336Q E154D, N190D, H225Y and E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y N229E and V258G and A289P and N303S and N336Q E154D, N190D, N229E and E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, V258G V258G and A289P and N303S and N336Q and A289P E154D, N190D, V258G and E154D, N190D, V258G E154D, N190D, A289P E154D, N190D, A289P and E154D, N190D, N303S N303S and N336Q and N303S N336Q and N336Q E154D, H225Y, N229E and E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, V258G V258G and A289P and N303S and N336Q and A289P E154D, H225Y, V258G and E154D, H225Y, V258G E154D, H225Y, A289P E154D, H225Y, A289P and E154D, H225Y, N303S N303S and N336Q and N303S N336Q and N336Q E154D, N229E, V258G and E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, A289P and E154D, N229E, A289P A289P and N303S and N336Q N303S and N336Q E154D, N229E, N303S and E154D, V258G, A289P E154D, V258G, A289P E154D, V258G, N303S and E154D, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q N190D, H225Y, N229E and N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, V258G V258G and A289P and N303S and N336Q and A289P N190D, H225Y, V258G and N190D, H225Y, V258G N190D, H225Y, A289P N190D, H225Y, A289P N190D, H225Y, N303S N303S and N336Q and N303S and N336Q and N336Q N190D, N229E, V258G and N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, A289P and N190D, N229E, A289P A289P and N303S and N336Q N303S and N336Q N190D, N229E, N303S and N190D, V258G, A289P N190D, V258G, A289P N190D, V258G, N303S N190D, A289P, N303S N336Q and N303S and N336Q and N336Q and N336Q H225Y, N229E, V258G and H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, A289P and H225Y, N229E, A289P A289P and N303S and N336Q N303S and N336Q H225Y, N229E, N303S and H225Y, V258G, A289P H225Y, V258G, A289P H225Y, V258G, N303S H225Y, A289P, N303S N336Q and N303S and N336Q and N336Q and N336Q N229E, V258G, A289P and N229E, V258G, A289P N229E, V258G, N303S N229E, A289P, N303S and V258G, A289P, N303S N303S and N336Q and N336Q N336Q and N336Q A60T, N61D, T63I and Q64K A60T, N61D, T63I and A60T, N61D, T63I and A60T, N61D, T63I and A60T, N61D, T63I and V74K N76G H146S F227L A60T, N61D, T63I and E229N A60T, N61D, Q64K and A60T, N61D, Q64K and A60T, N61D, Q64K and A60T, N61D, Q64K and V74K N76G H146S F227L A60T, N61D, Q64K and A60T, N61D, V74K and A60T, N61D, V74K and A60T, N61D, V74K and A60T, N61D, V74K and E229N N76G H146S F227L E229N A60T, N61D, N76G and A60T, N61D, N76G and A60T, N61D, N76G and A60T, N61D, H146S and A60T, N61D, H146S and H146S F227L E229N F227L E229N A60T, N61D, F227L and A60T, T63I, Q64K and A60T, T63I, Q64K and A60T, T63I, Q64K and A60T, T63I, Q64K and E229N V74K N76G H146S F227L A60T, T63I, Q64K and E229N A60T, T63I, V74K and A60T, T63I, V74K and A60T, T63I, V74K and A60T, T63I, V74K and N76G H146S F227L E229N A60T, T63I, N76G and H146S A60T, T63I, N76G and A60T, T63I, N76G and A60T, T63I, H146S and A60T, T63I, H146S and F227L E229N F227L E229N A60T, T63I, F227L and E229N A60T, Q64K, V74K and A60T, Q64K, V74K and A60T, Q64K, V74K and A60T, Q64K, V74K and N76G H146S F227L E229N A60T, Q64K, N76G and A60T, Q64K, N76G and A60T, Q64K, N76G and A60T, Q64K, H146S and A60T, Q64K, H146S and H146S F227L E229N F227L E229N A60T, Q64K, F227L and A60T, V74K, N76G and A60T, V74K, N76G and A60T, V74K, N76G and A60T, V74K, H146S and E229N H146S F227L E229N F227L A60T, V74K, H146S and A60T, V74K, F227L and A60T, N76G, H146S and A60T, N76G, H146S and A60T, N76G, F227L and E229N E229N F227L E229N E229N A60T, H146S, F227L and N61D, T63I, Q64K and N61D, T63I, Q64K and N61D, T63I, Q64K and N61D, T63I, Q64K and E229N V74K N76G H146S F227L N61D, T63I, Q64K and E229N N61D, T63I, V74K and N61D, T63I, V74K and N61D, T63I, V74K and N61D, T63I, V74K and N76G H146S F227L E229N N61D, T63I, N76G and H146S N61D, T63I, N76G and N61D, T63I, N76G and N61D, T63I, H146S and N61D, T63I, H146S and F227L E229N F227L E229N N61D, T63I, F227L and N61D, Q64K, V74K and N61D, Q64K, V74K and N61D, Q64K, V74K and N61D, Q64K, V74K and E229N N76G H146S F227L E229N N61D, Q64K, N76G and N61D, Q64K, N76G and N61D, Q64K, N76G and N61D, Q64K, H146S and N61D, Q64K, H146S and H146S F227L E229N F227L E229N N61D, Q64K, F227L and N61D, V74K, N76G and N61D, V74K, N76G and N61D, V74K, N76G and N61D, V74K, H146S and E229N H146S F227L E229N F227L N61D, V74K, H146S and N61D, V74K, F227L and N61D, N76G, H146S and N61D, N76G, H146S and N61D, N76G, F227L and E229N E229N F227L E229N E229N N61D, H146S, F227L and T63I, Q64K, V74K and T63I, Q64K, V74K and T63I, Q64K, V74K and T63I, Q64K, V74K and E229N N76G H146S F227L E229N T63I, Q64K, N76G and H146S T63I, Q64K, N76G and T63I, Q64K, N76G and T63I, Q64K, H146S and T63I, Q64K, H146S and F227L E229N F227L E229N T63I, Q64K, F227L and T63I, V74K, N76G and T63I, V74K, N76G and T63I, V74K, N76G and T63I, V74K, H146S and E229N H146S F227L E229N F227L T63I, V74K, H146S and T63I, V74K, F227L and T63I, N76G, H146S and T63I, N76G, H146S and T63I, N76G, F227L and E229N E229N F227L E229N E229N T63I, H146S, F227L and Q64K, V74K, N76G and Q64K, V74K, N76G and Q64K, V74K, N76G and Q64K, V74K, H146S and E229N H146S F227L E229N F227L Q64K, V74K, H146S and Q64K, V74K, F227L and Q64K, N76G, H146S and Q64K, N76G, H146S and Q64K, N76G, F227L and E229N E229N F227L E229N E229N Q64K, H146S, F227L and V74K, N76G, H146S and V74K, N76G, H146S and V74K, N76G, F227L and V74K, H146S, F227L and E229N F227L E229N E229N E229N N76G, H146S, F227L and A60T, N61D, T63I, Q64K A60T, N61D, T63I, Q64K A60T, N61D, T63I, Q64K A60T, N61D, T63I, Q64K E229N and V74K and N76G and H146S and F227L A60T, N61D, T63I, Q64K and A60T, N61D, T63I, V74K A60T, N61D, T63I, V74K A60T, N61D, T63I, V74K A60T, N61D, T63I, V74K E229N and N76G and H146S and F227L and E229N A60T, N61D, T63I, N76G and A60T, N61D, T63I, N76G A60T, N61D, T63I, N76G A60T, N61D, T63I, H146S A60T, N61D, T63I, H146S and F227L and E229N and F227L H146S and E229N A60T, N61D, T63I, F227L and A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, V74K A60T, N61D, Q64K, E229N V74K and N76G V74K and H146S and F227L V74K and E229N A60T, N61D, Q64K, N76G A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, and H146S N76G and F227L N76G and E229N H146S and F227L H146S and E229N A60T, N61D, Q64K, F227L A60T, N61D, V74K, A60T, N61D, V74K, A60T, N61D, V74K, N76G A60T, N61D, V74K, and E229N N76G and H146S N76G and F227L and E229N H146S and F227L A60T, N61D, V74K, H146S A60T, N61D, V74K, A60T, N61D, N76G, A60T, N61D, N76G, A60T, N61D, N76G, and E229N F227L and E229N H146S and F227L H146S and E229N F227L and E229N A60T, N61D, H146S, F227L A60T, T63I, Q64K, V74K A60T, T63I, Q64K, V74K A60T, T63I, Q64K, V74K A60T, T63I, Q64K, V74K and E229N and N76G and H146S and F227L and E229N A60T, T63I, Q64K, N76G and A60T, T63I, Q64K, N76G A60T, T63I, Q64K, N76G A60T, T63I, Q64K, H146S A60T, T63I, Q64K, H146S and F227L and E229N and F227L H146S and E229N A60T, T63I, Q64K, F227L and A60T, T63I, V74K, N76G A60T, T63I, V74K, N76G A60T, T63I, V74K, N76G A60T, T63I, V74K, E229N and H146S and F227L and E229N H146S and F227L A60T, T63I, V74K, H146S and A60T, T63I, V74K, A60T, T63I, N76G, A60T, T63I, N76G, H146S A60T, T63I, N76G, E229N F227L and E229N H146S and F227L and E229N F227L and E229N A60T, T63I, H146S, F227L A60T, Q64K, V74K, A60T, Q64K, V74K, A60T, Q64K, V74K, N76G A60T, Q64K, V74K, and E229N N76G and H146S N76G and F227L and E229N H146S and F227L A60T, Q64K, V74K, H146S A60T, Q64K, V74K, A60T, Q64K, N76G, A60T, Q64K, N76G, A60T, Q64K, N76G, and E229N F227L and E229N H146S and F227L H146S and E229N F227L and E229N A60T, Q64K, H146S, F227L A60T, V74K, N76G, A60T, V74K, N76G, A60T, V74K, N76G, A60T, V74K, H146S, and E229N H146S and F227L H146S and E229N F227L and E229N F227L and E229N A60T, N76G, H146S, F227L N61D, T63I, Q64K, V74K N61D, T63I, Q64K, V74K N61D, T63I, Q64K, V74K N61D, T63I, Q64K, V74K and E229N and N76G and H146S and F227L and E229N N61D, T63I, Q64K, N76G and N61D, T63I, Q64K, N76G N61D, T63I, Q64K, N76G N61D, T63I, Q64K, H146S N61D, T63I, Q64K, H146S and F227L and E229N and F227L H146S and E229N N61D, T63I, Q64K, F227L and N61D, T63I, V74K, N76G N61D, T63I, V74K, N76G N61D, T63I, V74K, N76G N61D, T63I, V74K, E229N and H146S and F227L and E229N H146S and F227L N61D, T63I, V74K, H146S N61D, T63I, V74K, N61D, T63I, N76G, N61D, T63I, N76G, H146S N61D, T63I, N76G, and E229N F227L and E229N H146S and F227L and E229N F227L and E229N N61D, T63I, H146S, F227L N61D, Q64K, V74K, N61D, Q64K, V74K, N61D, Q64K, V74K, N76G N61D, Q64K, V74K, and E229N N76G and H146S N76G and F227L and E229N H146S and F227L N61D, Q64K, V74K, H146S N61D, Q64K, V74K, N61D, Q64K, N76G, N61D, Q64K, N76G, N61D, Q64K, N76G, and E229N F227L and E229N H146S and F227L H146S and E229N F227L and E229N N61D, Q64K, H146S, F227L N61D, V74K, N76G, N61D, V74K, N76G, N61D, V74K, N76G, N61D, V74K, H146S, and E229N H146S and F227L H146S and E229N F227L and E229N F227L and E229N N61D, N76G, H146S, F227L T63I, Q64K, V74K, N76G T63I, Q64K, V74K, N76G T63I, Q64K, V74K, N76G T63I, Q64K, V74K, and E229N and H146S and F227L and E229N H146S and F227L T63I, Q64K, V74K, H146S T63I, Q64K, V74K, T63I, Q64K, N76G, T63I, Q64K, N76G, H146S T63I, Q64K, N76G, and E229N F227L and E229N H146S and F227L and E229N F227L and E229N T63I, Q64K, H146S, F227L T63I, V74K, N76G, T63I, V74K, N76G, T63I, V74K, N76G, F227L T63I, V74K, H146S, and E229N H146S and F227L H146S and E229N and E229N F227L and E229N T63I, N76G, H146S, F227L Q64K, V74K, N76G, Q64K, V74K, N76G, Q64K, V74K, N76G, Q64K, V74K, H146S, and E229N H146S and F227L H146S and E229N F227L and E229N F227L and E229N Q64K, N76G, H146S, F227L V74K, N76G, H146S, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and E229N F227L and E229NT85L, M134L and N190D M134L and H225Y M134L and N229E H121Y, N130K, M134L and E154D T85L, H121Y, N130K, M134L T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and V258G M134L and A289P M134L and N303S M134L and N336Q E154D and N190D T85L, H121Y, N130K, E154D T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and H225Y E154D and N229E E154D and V258G E154D and A289P E154D and N303S T85L, H121Y, N130K, E154D T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and N336Q N190D and H225Y N190D and N229E N190D and V258G N190D and A289P T85L, H121Y, N130K, N190D T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and N303S N190D and N336Q H225Y and N229E H225Y and V258G H225Y and A289P T85L, H121Y, N130K, H225Y T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and N303S H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S T85L, H121Y, N130K, N229E T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, H121Y, N130K, A289P T85L, H121Y, N130K, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, and N336Q N303S and N336Q E154D and N190D E154D and H225Y E154D and N229E T85L, H121Y, M134L, E154D T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, and V258G E154D and A289P E154D and N303S E154D and N336Q N190D and H225Y T85L, H121Y, M134L, N190D T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, and N229E N190D and V258G N190D and A289P N190D and N303S N190D and N336Q T85L, H121Y, M134L, H225Y T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, and N229E H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q T85L, H121Y, M134L, N229E T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P T85L, H121Y, M134L, V258G T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, H121Y, E154D, N190D T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, and H225Y N190D and N229E N190D and V258G N190D and A289P N190D and N303S T85L, H121Y, E154D, N190D T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S T85L, H121Y, E154D, H225Y T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, H121Y, E154D, V258G T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, H121Y, E154D, N303S T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S T85L, H121Y, N190D, H225Y T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, H121Y, N190D, V258G T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, H121Y, N190D, N303S T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, H121Y, H225Y, V258G T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, H121Y, H225Y, N303S T85L, H121Y, N229E, T85L, H121Y, N229E, T85L, H121Y, N229E, T85L, H121Y, N229E, and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, H121Y, N229E, A289P T85L, H121Y, N229E, T85L, H121Y, V258G, T85L, H121Y, V258G, T85L, H121Y, V258G, and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, H121Y, A289P, N303S T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, and N336Q E154D and N190D E154D and H225Y E154D and N229E E154D and V258G T85L, N130K, M134L, E154D T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, and A289P E154D and N303S E154D and N336Q N190D and H225Y N190D and N229E T85L, N130K, M134L, N190D T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, and V258G N190D and A289P N190D and N303S N190D and N336Q H225Y and N229E T85L, N130K, M134L, H225Y T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, and V258G H225Y and A289P H225Y and N303S H225Y and N336Q N229E and V258G T85L, N130K, M134L, N229E T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, and A289P N229E and N303S N229E and N336Q V258G and A289P V258G and N303S T85L, N130K, M134L, V258G T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, E154D, and N336Q A289P and N303S A289P and N336Q N303S and N336Q N190D and H225Y T85L, N130K, E154D, N190D T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, and N229E N190D and V258G N190D and A289P N190D and N303S N190D and N336Q T85L, N130K, E154D, H225Y T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, and N229E H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q T85L, N130K, E154D, N229E T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P T85L, N130K, E154D, V258G T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, N130K, N190D, H225Y T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, and N229E H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q T85L, N130K, N190D, N229E T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P T85L, N130K, N190D, V258G T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, N130K, H225Y, N229E T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P T85L, N130K, H225Y, V258G T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, N130K, N229E, V258G T85L, N130K, N229E, T85L, N130K, N229E, T85L, N130K, N229E, T85L, N130K, N229E, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, N130K, N229E, N303S T85L, N130K, V258G, T85L, N130K, V258G, T85L, N130K, V258G, T85L, N130K, A289P, and N336Q A289P and N303S A289P and N336Q N303S and N336Q N303S and N336Q T85L, M134L, E154D, N190D T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, and H225Y N190D and N229E N190D and V258G N190D and A289P N190D and N303S T85L, M134L, E154D, N190D T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S T85L, M134L, E154D, H225Y T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, M134L, E154D, V258G T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, M134L, E154D, N303S T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S T85L, M134L, N190D, H225Y T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, M134L, N190D, V258G T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, M134L, N190D, N303S T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, M134L, H225Y, V258G T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, M134L, H225Y, N303S T85L, M134L, N229E, T85L, M134L, N229E, T85L, M134L, N229E, T85L, M134L, N229E, and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, M134L, N229E, A289P T85L, M134L, N229E, T85L, M134L, V258G, T85L, M134L, V258G, T85L, M134L, V258G, and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, M134L, A289P, N303S T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S T85L, E154D, N190D, H225Y T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, E154D, N190D, V258G T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, E154D, N190D, N303S T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, E154D, H225Y, V258G T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, E154D, H225Y, N303S T85L, E154D, N229E, T85L, E154D, N229E, T85L, E154D, N229E, T85L, E154D, N229E, and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, E154D, N229E, A289P T85L, E154D, N229E, T85L, E154D, V258G, T85L, E154D, V258G, T85L, E154D, V258G, and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, E154D, A289P, N303S T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q T85L, N190D, H225Y, V258G T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q T85L, N190D, H225Y, N303S T85L, N190D, N229E, T85L, N190D, N229E, T85L, N190D, N229E, T85L, N190D, N229E, and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, N190D, N229E, A289P T85L, N190D, N229E, T85L, N190D, V258G, T85L, N190D, V258G, T85L, N190D, V258G, and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, N190D, A289P, N303S T85L, H225Y, N229E, T85L, H225Y, N229E, T85L, H225Y, N229E, T85L, H225Y, N229E, and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, H225Y, N229E, A289P T85L, H225Y, N229E, T85L, H225Y, V258G, T85L, H225Y, V258G, T85L, H225Y, V258G, and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, H225Y, A289P, N303S T85L, N229E, V258G, T85L, N229E, V258G, T85L, N229E, V258G, T85L, N229E, A289P, and N336Q A289P and N303S A289P and N336Q N303S and N336Q N303S and N336Q T85L, V258G, A289P, N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, and N336Q E154D and N190D E154D and H225Y E154D and N229E E154D and V258G H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D and A289P E154D and N303S E154D and N336Q N190D and H225Y N190D and N229E H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D and V258G N190D and A289P N190D and N303S N190D and N336Q H225Y and N229E H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q N229E and V258G H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N229E and A289P N229E and N303S N229E and N336Q V258G and A289P V258G and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, E154D, V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q N190D and H225Y H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N190D and N229E N190D and V258G N190D and A289P N190D and N303S N190D and N336Q H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N229E and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S H225Y and N336Q H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, N229E and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, N229E and V258G N229E and A289P N229E and N303S N229E and N336Q V258G and A289P H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, N130K, N229E, H121Y, N130K, N229E, H121Y, N130K, N229E, H121Y, N130K, N229E, H121Y, N130K, N229E, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, N130K, N229E, H121Y, N130K, V258G, H121Y, N130K, V258G, H121Y, N130K, V258G, H121Y, N130K, A289P, N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q N303S and N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D and H225Y N190D and N229E N190D and V258G N190D and A289P N190D and N303S H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, M134L, E154D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, N303S and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, M134L, N190D, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, N303S and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, M134L, H225Y, H121Y, M134L, N229E, H121Y, M134L, N229E, H121Y, M134L, N229E, H121Y, M134L, N229E, N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S H121Y, M134L, N229E, H121Y, M134L, N229E, H121Y, M134L, V258G, H121Y, M134L, V258G, H121Y, M134L, V258G, A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, M134L, A289P, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, N303S and N336Q H225Y and N229E H225Y and V258G H225Y and A289P H225Y and N303S H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, E154D, N190D, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, N303S and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, E154D, H225Y, H121Y, E154D, N229E, H121Y, E154D, N229E, H121Y, E154D, N229E, H121Y, E154D, N229E, N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S H121Y, E154D, N229E, H121Y, E154D, N229E, H121Y, E154D, V258G, H121Y, E154D, V258G, H121Y, E154D, V258G, A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, E154D, A289P, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, N303S and N336Q N229E and V258G N229E and A289P N229E and N303S N229E and N336Q H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, V258G and A289P V258G and N303S V258G and N336Q A289P and N303S A289P and N336Q H121Y, N190D, H225Y, H121Y, N190D, N229E, H121Y, N190D, N229E, H121Y, N190D, N229E, H121Y, N190D, N229E, N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S H121Y, N190D, N229E, H121Y, N190D, N229E, H121Y, N190D, V258G, H121Y, N190D, V258G, H121Y, N190D, V258G, A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, N190D, A289P, H121Y, H225Y, N229E, H121Y, H225Y, N229E, H121Y, H225Y, N229E, H121Y, H225Y, N229E, N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S H121Y, H225Y, N229E, H121Y, H225Y, N229E, H121Y, H225Y, V258G, H121Y, H225Y, V258G, H121Y, H225Y, V258G, A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q H121Y, H225Y, A289P, H121Y, N229E, V258G, H121Y, N229E, V258G, H121Y, N229E, V258G, H121Y, N229E, A289P, N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q N303S and N336Q H121Y, V258G, A289P, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N303S and N336Q N190D and H225Y N190D and N229E N190D and V258G N190D and A289P N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D and N303S N190D and N336Q H225Y and N229E H225Y and V258G H225Y and A289P N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, H225Y and N303S H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, A289P and N336Q N303S and N336Q H225Y and N229E H225Y and V258G H225Y and A289P N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, H225Y and N303S H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, A289P and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, N229E, N130K, M134L, N229E, N130K, M134L, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q N130K, M134L, N229E, N130K, M134L, N229E, N130K, M134L, N229E, N130K, M134L, V258G, N130K, M134L, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N130K, M134L, V258G, N130K, M134L, A289P, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N303S and N336Q N303S and N336Q H225Y and N229E H225Y and V258G H225Y and A289P N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, H225Y and N303S H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, A289P and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, N229E, N130K, E154D, N229E, N130K, E154D, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q N130K, E154D, N229E, N130K, E154D, N229E, N130K, E154D, N229E, N130K, E154D, V258G, N130K, E154D, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N130K, E154D, V258G, N130K, E154D, A289P, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N303S and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, N229E, N130K, N190D, N229E, N130K, N190D, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q N130K, N190D, N229E, N130K, N190D, N229E, N130K, N190D, N229E, N130K, N190D, V258G, N130K, N190D, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N130K, N190D, V258G, N130K, N190D, A289P, N130K, H225Y, N229E, N130K, H225Y, N229E, N130K, H225Y, N229E, N303S and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q N130K, H225Y, N229E, N130K, H225Y, N229E, N130K, H225Y, N229E, N130K, H225Y, V258G, N130K, H225Y, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N130K, H225Y, V258G, N130K, H225Y, A289P, N130K, N229E, V258G, N130K, N229E, V258G, N130K, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q N130K, N229E, A289P, N130K, V258G, A289P, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, N303S and N336Q N303S and N336Q H225Y and N229E H225Y and V258G H225Y and A289P M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y and N303S H225Y and N336Q N229E and V258G N229E and A289P N229E and N303S M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, A289P and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, V258G, M134L, E154D, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q M134L, E154D, V258G, M134L, E154D, A289P, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, N303S and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, V258G, M134L, N190D, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q M134L, N190D, V258G, M134L, N190D, A289P, M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, N229E, N303S and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, V258G, M134L, H225Y, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q M134L, H225Y, V258G, M134L, H225Y, A289P, M134L, N229E, V258G, M134L, N229E, V258G, M134L, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q M134L, N229E, A289P, M134L, V258G, A289P, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N303S and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, V258G, E154D, N190D, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q E154D, N190D, V258G, E154D, N190D, A289P, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, N303S and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, V258G, E154D, H225Y, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q E154D, H225Y, V258G, E154D, H225Y, A289P, E154D, N229E, V258G, E154D, N229E, V258G, E154D, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q E154D, N229E, A289P, N303S E154D, V258G, A289P, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, H225Y, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q N190D, H225Y, V258G, N190D, H225Y, A289P, N190D, N229E, V258G, N190D, N229E, V258G, N190D, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q N190D, N229E, A289P, N190D, V258G, A289P, H225Y, N229E, V258G, H225Y, N229E, V258G, H225Y, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q H225Y, N229E, A289P, H225Y, V258G, A289P, N229E, V258G, A289P, N303S and N336Q N303S and N336Q N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D and N190D M134L, E154D and M134L, E154D and M134L, E154D and V258G M134L, E154D and H225Y N229E A289P T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D and N303S M134L, E154D and M134L, N190D and M134L, N190D and N229E M134L, N190D and N336Q H225Y V258G T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D and A289P M134L, N190D and M134L, N190D and M134L, H225Y and N229E M134L, H225Y and N303S N336Q V258G T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, H225Y and A289P M134L, H225Y and M134L, H225Y and M134L, N229E and V258G M134L, N229E and N303S N336Q A289P T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N229E and N303S M134L, N229E and M134L, V258G and M134L, V258G and N303S M134L, V258G and N336Q A289P N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, A289P and N303S M134L, A289P and M134L, N303S and E154D, N190D and H225Y E154D, N190D and N336Q N336Q N229E T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D and V258G E154D, N190D and E154D, N190D and E154D, N190D and N336Q E154D, H225Y and A289P N303S N229E T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y and V258G E154D, H225Y and E154D, H225Y and E154D, H225Y and N336Q E154D, N229E and A289P N303S V258G T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N229E and A289P E154D, N229E and E154D, N229E and E154D, V258G and A289P E154D, V258G and N303S N336Q N303S T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, V258G and N336Q E154D, A289P and E154D, A289P and E154D, N303S and N336Q N190D, H225Y and N303S N336Q N229E T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y and V258G N190D, H225Y and N190D, H225Y and N190D, H225Y and N336Q N190D, N229E and A289P N303S V258G T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, N229E and A289P N190D, N229E and N190D, N229E and N190D, V258G and A289P N190D, V258G and N303S N336Q N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, V258G and N336Q N190D, A289P and N190D, A289P and N190D, N303S and N336Q H225Y, N229E and N303S N336Q V258G T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, N229E and A289P H225Y, N229E and H225Y, N229E and H225Y, V258G and A289P H225Y, V258G and N303S N336Q N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, V258G and N336Q H225Y, A289P and H225Y, A289P and H225Y, N303S and N336Q N229E, V258G and N303S N336Q A289P T85L, H121Y, N130K, N229E, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, M134L, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q E154D, N190D and N336Q N336Q H225Y T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D and N229E E154D, N190D and E154D, N190D and E154D, N190D and N303S E154D, N190D and V258G A289P N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y and N229E E154D, H225Y and E154D, H225Y and E154D, H225Y and N303S E154D, H225Y and V258G A289P N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N229E and V258G E154D, N229E and E154D, N229E and E154D, N229E and N336Q E154D, V258G and A289P N303S A289P T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, V258G and N303S E154D, V258G and E154D, A289P and E154D, A289P and N336Q E154D, N303S and N336Q N303S N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y and N229E N190D, H225Y and N190D, H225Y and N190D, H225Y and N303S N190D, H225Y and V258G A289P N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, N229E and V258G N190D, N229E and N190D, N229E and N190D, N229E and N336Q N190D, V258G and A289P N303S A289P T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, V258G and N303S N190D, V258G and N190D, A289P and N190D, A289P and N336Q N190D, N303S and N336Q N303S N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, N229E and V258G H225Y, N229E and H225Y, N229E and H225Y, N229E and N336Q H225Y, V258G and A289P N303S A289P T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, V258G and N303S H225Y, V258G and H225Y, A289P and H225Y, A289P and N336Q H225Y, N303S and N336Q N303S N336Q T85L, H121Y, M134L, N229E, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q T85L, H121Y, M134L, N229E, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, H225Y and N229E N190D, H225Y and N190D, H225Y and N190D, H225Y and N303S N190D, H225Y and V258G A289P N336Q T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, N229E and V258G N190D, N229E and N190D, N229E and N190D, N229E and N336Q N190D, V258G and A289P N303S A289P T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, V258G and N303S N190D, V258G and N190D, A289P and N190D, A289P and N336Q N190D, N303S and N336Q N303S N336Q T85L, H121Y, E154D, H225Y, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, N229E and V258G H225Y, N229E and H225Y, N229E and H225Y, N229E and N336Q H225Y, V258G and A289P N303S A289P T85L, H121Y, E154D, H225Y, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, V258G and N303S H225Y, V258G and H225Y, A289P and H225Y, A289P and N336Q H225Y, N303S and N336Q N303S N336Q T85L, H121Y, E154D, N229E, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q T85L, H121Y, E154D, N229E, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, H225Y, N229E and V258G H225Y, N229E and H225Y, N229E and H225Y, N229E and N336Q H225Y, V258G and A289P N303S A289P T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, H225Y, V258G and N303S H225Y, V258G and H225Y, A289P and H225Y, A289P and N336Q H225Y, N303S and N336Q N303S N336Q T85L, H121Y, N190D, N229E, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q T85L, H121Y, N190D, N229E, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, H225Y, N229E, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q T85L, H121Y, H225Y, N229E, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, N229E, V258G, T85L, H121Y, N229E, T85L, H121Y, N229E, T85L, H121Y, N229E, T85L, H121Y, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D and H225Y E154D, N190D and E154D, N190D and E154D, N190D and A289P E154D, N190D and N229E V258G N303S T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D and N336Q E154D, H225Y and E154D, H225Y and E154D, H225Y and A289P E154D, H225Y and N229E V258G N303S T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y and N336Q E154D, N229E and E154D, N229E and E154D, N229E and N303S E154D, N229E and V258G A289P N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, V258G and A289P E154D, V258G and E154D, V258G and E154D, A289P and N303S E154D, A289P and N303S N336Q N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N303S and N336Q N190D, H225Y and N190D, H225Y and N190D, H225Y and A289P N190D, H225Y and N229E V258G N303S T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y and N336Q N190D, N229E and N190D, N229E and N190D, N229E and N303S N190D, N229E and V258G A289P N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, V258G and A289P N190D, V258G and N190D, V258G and N190D, A289P and N303S N190D, A289P and N303S N336Q N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, N303S and N336Q H225Y, N229E and H225Y, N229E and H225Y, N229E and N303S H225Y, N229E and V258G A289P N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, V258G and A289P H225Y, V258G and H225Y, V258G and H225Y, A289P and N303S H225Y, A289P and N303S N336Q N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, N130K, M134L, N229E, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N130K, M134L, A289P, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, N303S and N336Q N190D, H225Y and N190D, H225Y and N190D, H225Y and A289P N190D, H225Y and N229E V258G N303S T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, H225Y and N336Q N190D, N229E and N190D, N229E and N190D, N229E and N303S N190D, N229E and V258G A289P N336Q T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, V258G and A289P N190D, V258G and N190D, V258G and N190D, A289P and N303S N190D, A289P and N303S N336Q N336Q T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, N303S and N336Q H225Y, N229E and H225Y, N229E and H225Y, N229E and N303S H225Y, N229E and V258G A289P N336Q T85L, N130K, E154D, H225Y, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, V258G and A289P H225Y, V258G and H225Y, V258G and H225Y, A289P and N303S H225Y, A289P and N303S N336Q N336Q T85L, N130K, E154D, H225Y, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, N130K, E154D, N229E, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N130K, E154D, A289P, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, N303S and N336Q H225Y, N229E and H225Y, N229E and H225Y, N229E and N303S H225Y, N229E and V258G A289P N336Q T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, H225Y, V258G and A289P H225Y, V258G and H225Y, V258G and H225Y, A289P and N303S H225Y, A289P and N303S N336Q N336Q T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, N130K, N190D, N229E, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N130K, N190D, A289P, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, N130K, H225Y, N229E, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N130K, H225Y, A289P, T85L, N130K, N229E, T85L, N130K, N229E, T85L, N130K, N229E, T85L, N130K, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, N130K, V258G, A289P, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, N303S and N336Q N190D, H225Y and N190D, H225Y and N190D, H225Y and A289P N190D, H225Y and N229E V258G N303S T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, H225Y and N336Q N190D, N229E and N190D, N229E and N190D, N229E and N303S N190D, N229E and V258G A289P N336Q T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, V258G and A289P N190D, V258G and N190D, V258G and N190D, A289P and N303S N190D, A289P and N303S N336Q N336Q T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, N303S and N336Q H225Y, N229E and H225Y, N229E and H225Y, N229E and N303S H225Y, N229E and V258G A289P N336Q T85L, M134L, E154D, H225Y, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, V258G and A289P H225Y, V258G and H225Y, V258G and H225Y, A289P and N303S H225Y, A289P and N303S N336Q N336Q T85L, M134L, E154D, H225Y, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, M134L, E154D, N229E, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, M134L, E154D, A289P, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, N303S and N336Q H225Y, N229E and H225Y, N229E and H225Y, N229E and N303S H225Y, N229E and V258G A289P N336Q T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, H225Y, V258G and A289P H225Y, V258G and H225Y, V258G and H225Y, A289P and N303S H225Y, A289P and N303S N336Q N336Q T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, M134L, N190D, N229E, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, M134L, N190D, A289P, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, M134L, H225Y, N229E, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, H225Y, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, M134L, H225Y, A289P, T85L, M134L, N229E, T85L, M134L, N229E, T85L, M134L, N229E, T85L, M134L, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, M134L, V258G, A289P, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, N303S and N336Q H225Y, N229E and H225Y, N229E and H225Y, N229E and N303S H225Y, N229E and V258G A289P N336Q T85L, E154D, N190D, H225Y, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, V258G and A289P H225Y, V258G and H225Y, V258G and H225Y, A289P and N303S H225Y, A289P and N303S N336Q N336Q T85L, E154D, N190D, H225Y, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, E154D, N190D, N229E, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, E154D, N190D, A289P, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, E154D, H225Y, N229E, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, E154D, H225Y, A289P, T85L, E154D, N229E, T85L, E154D, N229E, T85L, E154D, N229E, T85L, E154D, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, E154D, V258G, A289P, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, N190D, H225Y, N229E, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N190D, H225Y, A289P, T85L, N190D, N229E, T85L, N190D, N229E, T85L, N190D, N229E, T85L, N190D, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, N190D, V258G, A289P, T85L, H225Y, N229E, T85L, H225Y, N229E, T85L, H225Y, N229E, T85L, H225Y, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H225Y, V258G, A289P, T85L, N229E, V258G, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N303S and N336Q A289P, N303S and E154D, N190D and E154D, N190D and N229E E154D, N190D and N336Q H225Y V258G H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D and A289P E154D, N190D and E154D, N190D and E154D, H225Y and N229E E154D, H225Y and N303S N336Q V258G H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, H225Y and A289P E154D, H225Y and E154D, H225Y and E154D, N229E and V258G E154D, N229E and N303S N336Q A289P H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N229E and N303S E154D, N229E and E154D, V258G and E154D, V258G and N303S E154D, V258G and N336Q A289P N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, A289P and N303S E154D, A289P and E154D, N303S and N190D, H225Y and N229E N190D, H225Y and N336Q N336Q V258G H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, H225Y and A289P N190D, H225Y and N190D, H225Y and N190D, N229E and V258G N190D, N229E and N303S N336Q A289P H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, N229E and N303S N190D, N229E and N190D, V258G and N190D, V258G and N303S N190D, V258G and N336Q A289P N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, A289P and N303S N190D, A289P and N190D, N303S and H225Y, N229E and V258G H225Y, N229E and N336Q N336Q A289P H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y, N229E and N303S H225Y, N229E and H225Y, V258G and H225Y, V258G and N303S H225Y, V258G and N336Q A289P N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y, A289P and N303S H225Y, A289P and H225Y, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, E154D, H121Y, N130K, E154D, V258G, A289P and N336Q V258G, N303S and A289P, N303S and N190D, H225Y and N229E N190D, H225Y and N336Q N336Q V258G H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N190D, H225Y and A289P N190D, H225Y and N190D, H225Y and N190D, N229E and V258G N190D, N229E and N303S N336Q A289P H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N190D, N229E and N303S N190D, N229E and N190D, V258G and N190D, V258G and N303S N190D, V258G and N336Q A289P N336Q H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N190D, A289P and N303S N190D, A289P and N190D, N303S and H225Y, N229E and V258G H225Y, N229E and N336Q N336Q A289P H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H225Y, N229E and N303S H225Y, N229E and H225Y, V258G and H225Y, V258G and N303S H225Y, V258G and N336Q A289P N336Q H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H225Y, A289P and N303S H225Y, A289P and H225Y, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, N190D, H121Y, N130K, N190D, V258G, A289P and N336Q V258G, N303S and A289P, N303S and H225Y, N229E and V258G H225Y, N229E and N336Q N336Q A289P H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H225Y, N229E and N303S H225Y, N229E and H225Y, V258G and H225Y, V258G and N303S H225Y, V258G and N336Q A289P N336Q H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H225Y, A289P and N303S H225Y, A289P and H225Y, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, N190D, H121Y, N130K, H225Y, H121Y, N130K, H225Y, V258G, A289P and N336Q V258G, N303S and A289P, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, N229E, H121Y, N130K, N229E, V258G, A289P and N336Q V258G, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, N130K, N229E, H121Y, N130K, N229E, H121Y, N130K, V258G, H121Y, M134L, E154D, H121Y, M134L, E154D, V258G, N303S and N336Q A289P, N303S and A289P, N303S and N190D, H225Y and N229E N190D, H225Y and N336Q N336Q V258G H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, H225Y and A289P N190D, H225Y and N190D, H225Y and N190D, N229E and V258G N190D, N229E and N303S N336Q A289P H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, N229E and N303S N190D, N229E and N190D, V258G and N190D, V258G and N303S N190D, V258G and N336Q A289P N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, A289P and N303S N190D, A289P and N190D, N303S and H225Y, N229E and V258G H225Y, N229E and N336Q N336Q A289P H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H225Y, N229E and N303S H225Y, N229E and H225Y, V258G and H225Y, V258G and N303S H225Y, V258G and N336Q A289P N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H225Y, A289P and N303S H225Y, A289P and H225Y, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, N190D, H121Y, M134L, N190D, V258G, A289P and N336Q V258G, N303S and A289P, N303S and H225Y, N229E and V258G H225Y, N229E and N336Q N336Q A289P H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H225Y, N229E and N303S H225Y, N229E and H225Y, V258G and H225Y, V258G and N303S H225Y, V258G and N336Q A289P N336Q H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H225Y, A289P and N303S H225Y, A289P and H225Y, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, H225Y, H121Y, M134L, H225Y, V258G, A289P and N336Q V258G, N303S and A289P, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, N229E, H121Y, M134L, N229E, V258G, A289P and N336Q V258G, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, M134L, N229E, H121Y, M134L, N229E, H121Y, M134L, V258G, H121Y, E154D, N190D, H121Y, E154D, N190D, V258G, N303S and N336Q A289P, N303S and A289P, N303S and H225Y, N229E and V258G H225Y, N229E and N336Q N336Q A289P H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H225Y, N229E and N303S H225Y, N229E and H225Y, V258G and H225Y, V258G and N303S H225Y, V258G and N336Q A289P N336Q H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H225Y, A289P and N303S H225Y, A289P and H225Y, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, H225Y, H121Y, E154D, H225Y, V258G, A289P and N336Q V258G, N303S and A289P, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, N229E, H121Y, E154D, N229E, V258G, A289P and N336Q V258G, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, E154D, N229E, H121Y, E154D, N229E, H121Y, E154D, V258G, H121Y, N190D, H225Y, H121Y, N190D, H225Y, V258G, N303S and N336Q A289P, N303S and A289P, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, N229E, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, N229E, H121Y, N190D, N229E, V258G, A289P and N336Q V258G, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, N190D, N229E, H121Y, N190D, N229E, H121Y, N190D, V258G, H121Y, H225Y, N229E, H121Y, H225Y, N229E, V258G, N303S and N336Q A289P, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, H225Y, N229E, H121Y, H225Y, N229E, H121Y, H225Y, V258G, H121Y, N229E, V258G, N130K, M134L, E154D, V258G, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q N190D, H225Y and N336Q N336Q N229E N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, H225Y and V258G N190D, H225Y and N190D, H225Y and N190D, H225Y and N336Q N190D, N229E and A289P N303S V258G N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, N229E and A289P N190D, N229E and N190D, N229E and N190D, V258G and A289P N190D, V258G and N303S N336Q N303S N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, V258G and N336Q N190D, A289P and N190D, A289P and N190D, N303S and N336Q H225Y, N229E and N303S N336Q V258G N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, H225Y, N229E and A289P H225Y, N229E and H225Y, N229E and H225Y, V258G and A289P H225Y, V258G and N303S N336Q N303S N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, H225Y, V258G and N336Q H225Y, A289P and H225Y, A289P and H225Y, N303S and N336Q N229E, V258G and N303S N336Q A289P N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N229E, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, N190D, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q H225Y, N229E and N336Q N336Q V258G N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, H225Y, N229E and A289P H225Y, N229E and H225Y, N229E and H225Y, V258G and A289P H225Y, V258G and N303S N336Q N303S N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, H225Y, V258G and N336Q H225Y, A289P and H225Y, A289P and H225Y, N303S and N336Q N229E, V258G and N303S N336Q A289P N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N229E, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, H225Y, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q N229E, V258G and N336Q N336Q A289P N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N229E, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, N229E, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q V258G, A289P and N336Q N336Q N303S N130K, M134L, N229E, N130K, M134L, N229E, N130K, M134L, N229E, N130K, M134L, V258G, N130K, E154D, N190D, V258G, A289P and N336Q V258G, N303S and A289P, N303S and A289P, N303S and N336Q H225Y, N229E and N336Q N336Q V258G N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, H225Y, N229E and A289P H225Y, N229E and H225Y, N229E and H225Y, V258G and A289P H225Y, V258G and N303S N336Q N303S N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, H225Y, V258G and N336Q H225Y, A289P and H225Y, A289P and H225Y, N303S and N336Q N229E, V258G and N303S N336Q A289P N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N229E, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, H225Y, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q N229E, V258G and N336Q N336Q A289P N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N229E, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, N229E, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q V258G, A289P and N336Q N336Q N303S N130K, E154D, N229E, N130K, E154D, N229E, N130K, E154D, N229E, N130K, E154D, V258G, N130K, N190D, H225Y, V258G, A289P and N336Q V258G, N303S and A289P, N303S and A289P, N303S and N336Q N229E, V258G and N336Q N336Q A289P N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N229E, V258G and N303S N229E, V258G and N229E, A289P and N229E, A289P and N336Q N229E, N303S and N336Q N303S N336Q N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, N229E, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q V258G, A289P and N336Q N336Q N303S N130K, N190D, N229E, N130K, N190D, N229E, N130K, N190D, N229E, N130K, N190D, V258G, N130K, H225Y, N229E, V258G, A289P and N336Q V258G, N303S and A289P, N303S and A289P, N303S and N336Q V258G, A289P and N336Q N336Q N303S N130K, H225Y, N229E, N130K, H225Y, N229E, N130K, H225Y, N229E, N130K, H225Y, V258G, N130K, N229E, V258G, V258G, A289P and N336Q V258G, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y, N229E and V258G H225Y, N229E and H225Y, N229E and H225Y, N229E and N336Q H225Y, V258G and A289P N303S A289P M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y, V258G and N303S H225Y, V258G and H225Y, A289P and H225Y, A289P and N336Q H225Y, N303S and N336Q N303S N336Q M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, N229E, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, N229E, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, V258G, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, N229E, V258G and A289P N229E, V258G and N229E, V258G and N229E, A289P and N303S N229E, A289P and N303S N336Q N336Q M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, V258G, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, V258G, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q M134L, N229E, V258G, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N229E, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q E154D, N190D, H225Y, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, A289P, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q E154D, N190D, V258G, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, A289P, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q E154D, H225Y, V258G, E154D, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, A60T, N61D, T63I, A289P, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q Q64K, V74K and N76G N336Q N336Q A60T, N61D, T63I, Q64K, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, Q64K, A60T, N61D, T63I, V74K and H146S Q64K, V74K and F227L Q64K, V74K and E229N N76G and H146S Q64K, N76G and F227L A60T, N61D, T63I, Q64K, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, Q64K, A60T, N61D, T63I, N76G and E229N Q64K, H146S and F227L Q64K, H146S and E229N F227L and E229N V74K, N76G and H146S A60T, N61D, T63I, V74K, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, V74K, A60T, N61D, T63I, N76G and F227L V74K, N76G and E229N V74K, H146S and F227L H146S and E229N V74K, F227L and E229N A60T, N61D, T63I, N76G, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, H146S, A60T, N61D, Q64K, H146S and F227L N76G, H146S and E229N N76G, F227L and E229N F227L and E229N V74K, N76G and H146S A60T, N61D, Q64K, V74K, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, N76G and F227L V74K, N76G and E229N V74K, H146S and F227L V74K, H146S and E229N V74K, F227L and E229N A60T, N61D, Q64K, N76G, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, V74K, H146S and F227L N76G, H146S and E229N N76G, F227L and E229N H146S, F227L and E229N N76G, H146S and F227L A60T, N61D, V74K, N76G, A60T, N61D, V74K, A60T, N61D, V74K, A60T, N61D, N76G, A60T, T63I, Q64K, H146S and E229N N76G, F227L and E229N H146S, F227L and E229N H146S, F227L and E229N V74K, N76G and H146S A60T, T63I, Q64K, V74K, A60T, T63I, Q64K, A60T, T63I, Q64K, A60T, T63I, Q64K, V74K, A60T, T63I, Q64K, N76G and F227L V74K, N76G and E229N V74K, H146S and F227L H146S and E229N V74K, F227L and E229N A60T, T63I, Q64K, N76G, A60T, T63I, Q64K, A60T, T63I, Q64K, A60T, T63I, Q64K, H146S, A60T, T63I, V74K, H146S and F227L N76G, H146S and E229N N76G, F227L and E229N F227L and E229N N76G, H146S and F227L A60T, T63I, V74K, N76G, A60T, T63I, V74K, A60T, T63I, V74K, A60T, T63I, N76G, H146S, A60T, Q64K, V74K, H146S and E229N N76G, F227L and E229N H146S, F227L and E229N F227L and E229N N76G, H146S and F227L A60T, Q64K, V74K, N76G, A60T, Q64K, V74K, A60T, Q64K, V74K, A60T, Q64K, N76G, A60T, V74K, N76G, H146S and E229N N76G, F227L and E229N H146S, F227L and E229N H146S, F227L and E229N H146S, F227L and E229N N61D, T63I, Q64K, V74K, N61D, T63I, Q64K, N61D, T63I, Q64K, N61D, T63I, Q64K, V74K, N61D, T63I, Q64K, N76G and H146S V74K, N76G and F227L V74K, N76G and E229N H146S and F227L V74K, H146S and E229N N61D, T63I, Q64K, V74K, N61D, T63I, Q64K, N61D, T63I, Q64K, N61D, T63I, Q64K, N76G, N61D, T63I, Q64K, F227L and E229N N76G, H146S and F227L N76G, H146S and E229N F227L and E229N H146S, F227L and E229N N61D, T63I, V74K, N76G, N61D, T63I, V74K, N61D, T63I, V74K, N61D, T63I, V74K, N61D, T63I, N76G, H146S and F227L N76G, H146S and E229N N76G, F227L and E229N H146S, F227L and E229N H146S, F227L and E229N N61D, Q64K, V74K, N76G, N61D, Q64K, V74K, N61D, Q64K, V74K, N61D, Q64K, V74K, N61D, Q64K, N76G, H146S and F227L N76G, H146S and E229N N76G, F227L and E229N H146S, F227L and E229N H146S, F227L and E229N N61D, V74K, N76G, H146S, T63I, Q64K, V74K, T63I, Q64K, V74K, T63I, Q64K, V74K, N76G, T63I, Q64K, V74K, F227L and E229N N76G, H146S and F227L N76G, H146S and E229N F227L and E229N H146S, F227L and E229N T63I, Q64K, N76G, H146S, T63I, V74K, N76G, Q64K, V74K, N76G, F227L and E229N H146S, F227L and E229N H146S, F227L and E229N A60T, N61D, T63I, Q64K, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, Q64K, A60T, N61D, T63I, V74K, N76G and H146S Q64K, V74K, N76G and Q64K, V74K, N76G and V74K, H146S and F227L Q64K, V74K, H146S and F227L E229N E229N A60T, N61D, T63I, Q64K, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, Q64K, A60T, N61D, T63I, V74K, F227L and E229N Q64K, N76G, H146S and Q64K, N76G, H146S and N76G, F227L and E229N Q64K, H146S, F227L and F227L E229N E229N A60T, N61D, T63I, V74K, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, V74K, A60T, N61D, T63I, N76G, H146S and F227L V74K, N76G, H146S and V74K, N76G, F227L and H146S, F227L and E229N N76G, H146S, F227L and E229N E229N E229N A60T, N61D, Q64K, V74K, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, A60T, N61D, Q64K, N76G, H146S and F227L V74K, N76G, H146S and V74K, N76G, F227L and V74K, H146S, F227L and N76G, H146S, F227L and E229N E229N E229N E229N A60T, N61D, V74K, N76G, A60T, T63I, Q64K, A60T, T63I, Q64K, A60T, T63I, Q64K, V74K, A60T, T63I, Q64K, H146S, F227L and E229N V74K, N76G, H146S and V74K, N76G, H146S and N76G, F227L and E229N V74K, H146S, F227L and F227L E229N E229N A60T, T63I, Q64K, N76G, A60T, T63I, V74K, A60T, Q64K, V74K, N61D, T63I, Q64K, V74K, N61D, T63I, Q64K, H146S, F227L and E229N N76G, H146S, F227L and N76G, H146S, F227L and N76G, H146S and F227L V74K, N76G, H146S and E229N E229N E229N N61D, T63I, Q64K, V74K, N61D, T63I, Q64K, N61D, T63I, Q64K, N61D, T63I, V74K, N76G, N61D, Q64K, V74K, N76G, F227L and E229N V74K, H146S, F227L and N76G, H146S, F227L and H146S, F227L and E229N N76G, H146S, F227L and E229N E229N E229N T63I, Q64K, V74K, N76G, A60T, N61D, T63I, A60T, N61D, T63I, A60T, N61D, T63I, Q64K, A60T, N61D, T63I, H146S, F227L and E229N Q64K, V74K, N76G, Q64K, V74K, N76G, V74K, N76G, F227L and Q64K, V74K, H146S, H146S and F227L H146S and E229N E229N F227L and E229N A60T, N61D, T63I, Q64K, A60T, N61D, T63I, A60T, N61D, Q64K, A60T, T63I, Q64K, V74K, N61D, T63I, Q64K, N76G, H146S, F227L and V74K, N76G, H146S, V74K, N76G, H146S, N76G, H146S, F227L and V74K, N76G, H146S, E229N F227L and E229N F227L and E229N E229N F227L and E229N A60T, N61D, T63I, Q64K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, V74K, N76G, H146S, F227L M134L, E154D, N190D M134L, E154D, N190D M134L, E154D, N190D M134L, E154D, N190D and E229NT85L, H121Y, and N229E and V258G and A289P and N303S N130K, M134L, E154D, N190D and H225Y T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N190D and M134L, E154D, H225Y M134L, E154D, H225Y M134L, E154D, H225Y M134L, E154D, H225Y N336Q and N229E and V258G and A289P and N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, H225Y and M134L, E154D, N229E M134L, E154D, N229E M134L, E154D, N229E M134L, E154D, N229E N336Q and V258G and A289P and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, V258G and M134L, E154D, V258G M134L, E154D, V258G M134L, E154D, A289P M134L, E154D, A289P A289P and N303S and N336Q and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N303S and M134L, N190D, H225Y M134L, N190D, H225Y M134L, N190D, H225Y M134L, N190D, H225Y N336Q and N229E and V258G and A289P and N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, H225Y and M134L, N190D, N229E M134L, N190D, N229E M134L, N190D, N229E M134L, N190D, N229E N336Q and V258G and A289P and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, V258G and M134L, N190D, V258G M134L, N190D, V258G M134L, N190D, A289P M134L, N190D, A289P A289P and N303S and N336Q and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, N303S and M134L, H225Y, N229E M134L, H225Y, N229E M134L, H225Y, N229E M134L, H225Y, N229E N336Q and V258G and A289P and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, H225Y, V258G and M134L, H225Y, V258G M134L, H225Y, V258G M134L, H225Y, A289P M134L, H225Y, A289P A289P and N303S and N336Q and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, H225Y, N303S and M134L, N229E, V258G M134L, N229E, V258G M134L, N229E, V258G M134L, N229E, A289P N336Q and A289P and N303S and N336Q and N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N229E, A289P and M134L, N229E, N303S M134L, V258G, A289P M134L, V258G, A289P M134L, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, A289P, N303S and E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y N336Q and N229E and V258G and A289P and N303S T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y and N336Q E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E and V258G and A289P and N303S and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, V258G and A289P E154D, N190D, V258G E154D, N190D, V258G E154D, N190D, A289P and E154D, N190D, A289P and N303S and N336Q N303S and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, N303S and N336Q E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E and V258G and A289P and N303S and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, V258G and A289P E154D, H225Y, V258G E154D, H225Y, V258G E154D, H225Y, A289P and E154D, H225Y, A289P and N303S and N336Q N303S and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, N303S and N336Q E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, A289P and A289P and N303S and N336Q and N303S T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N229E, A289P and N336Q E154D, N229E, N303S E154D, V258G, A289P E154D, V258G, A289P and E154D, V258G, N303S and N336Q and N303S N336Q and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, A289P, N303S and N336Q N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E and V258G and A289P and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, V258G and N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N190D, H225Y, A289P A289P and N303S and N336Q and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, N303S and N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, A289P N336Q and A289P and N303S and N336Q and N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, N229E, A289P and N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P N190D, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, A289P, N303S and H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, A289P N336Q and A289P and N303S and N336Q and N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, N229E, A289P and H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P H225Y, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, A289P, N303S and N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q T85L, H121Y, N130K, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, V258G, A289P, N303S and E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y N336Q and N229E and V258G and A289P and N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y and N336Q E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E and V258G and A289P and N303S and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, V258G and A289P E154D, N190D, V258G E154D, N190D, V258G E154D, N190D, A289P and E154D, N190D, A289P and N303S and N336Q N303S and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, N303S and N336Q E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E and V258G and A289P and N303S and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, V258G and A289P E154D, H225Y, V258G E154D, H225Y, V258G E154D, H225Y, A289P and E154D, H225Y, A289P and N303S and N336Q N303S and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, N303S and N336Q E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, A289P and A289P and N303S and N336Q and N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N229E, A289P and N336Q E154D, N229E, N303S E154D, V258G, A289P E154D, V258G, A289P and E154D, V258G, N303S and N336Q and N303S N336Q and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, A289P, N303S and N336Q N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E and V258G and A289P and N303S and N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, V258G and N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N190D, H225Y, A289P A289P and N303S and N336Q and N303S and N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, N303S and N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, A289P N336Q and A289P and N303S and N336Q and N303S T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, N229E, A289P and N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P N190D, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, A289P, N303S and H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, A289P N336Q and A289P and N303S and N336Q and N303S T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, N229E, A289P and H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P H225Y, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, A289P, N303S and N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q T85L, H121Y, M134L, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, V258G, A289P, N303S and N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N336Q and V258G and A289P and N303S and N336Q T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, H225Y, V258G and A289P N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N190D, H225Y, A289P and N303S and N336Q and N303S and N336Q T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, H225Y, N303S and N336Q N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, A289P and A289P and N303S and N336Q and N303S T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, N229E, A289P and N336Q N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P N190D, V258G, N303S and N336Q and N303S and N336Q and N336Q T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, A289P, N303S and N336Q H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, A289P and A289P and N303S and N336Q and N303S T85L, H121Y, E154D, H225Y, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, N229E, A289P and N336Q H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P H225Y, V258G, N303S and N336Q and N303S and N336Q and N336Q T85L, H121Y, E154D, H225Y, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, A289P, N303S and N336Q N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S and N303S and N336Q N336Q and N336Q T85L, H121Y, E154D, V258G, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, A289P, N303S and N336Q H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, A289P and A289P and N303S and N336Q and N303S T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, H225Y, N229E, A289P and H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P H225Y, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, H225Y, A289P, N303S and N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q T85L, H121Y, N190D, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, T85L, H121Y, H225Y, V258G, A289P, N303S and N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q T85L, H121Y, H225Y, T85L, H121Y, N229E, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, V258G, A289P, N303S and V258G, A289P, N303S E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y N336Q and N336Q and N229E and V258G and A289P T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y and N303S E154D, N190D, H225Y E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E and N336Q and V258G and A289P and N303S T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, N229E and N336Q E154D, N190D, V258G E154D, N190D, V258G E154D, N190D, V258G E154D, N190D, A289P and A289P and N303S and N336Q and N303S T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, A289P and N336Q E154D, N190D, N303S E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E and N336Q and V258G and A289P and N303S T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, N229E and N336Q E154D, H225Y, V258G E154D, H225Y, V258G E154D, H225Y, V258G E154D, H225Y, A289P and A289P and N303S and N336Q and N303S T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, A289P and N336Q E154D, H225Y, N303S E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, V258G and N336Q and A289P and N303S and N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N229E, A289P and N303S E154D, N229E, A289P E154D, N229E, N303S E154D, V258G, A289P and E154D, V258G, A289P and N336Q and N336Q N303S and N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, V258G, N303S and N336Q E154D, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E and N336Q and V258G and A289P and N303S T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, N229E and N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N336Q and A289P and N303S and N336Q and N303S T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, A289P and N190D, H225Y, N303S N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, N229E, A289P and N190D, N229E, A289P N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, V258G, N303S and N190D, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, N229E, A289P and H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, V258G, N303S and H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q T85L, N130K, M134L, N229E, T85L, N130K, M134L, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, A289P, N303S and N336Q V258G, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E and N336Q and V258G and A289P and N303S T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, H225Y, N229E and N336Q N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P and A289P and N303S and N336Q and N303S T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, H225Y, A289P and N336Q N190D, H225Y, N303S N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G and N336Q and A289P and N303S and N336Q T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, N229E, A289P and N303S N190D, N229E, A289P N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P and N336Q and N336Q and N303S and N336Q T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, V258G, N303S and N336Q N190D, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G and N336Q and A289P and N303S and N336Q T85L, N130K, E154D, H225Y, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, N229E, A289P and N303S H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P and N336Q and N336Q and N303S and N336Q T85L, N130K, E154D, H225Y, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, V258G, N303S and N336Q H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S and N336Q and N303S N336Q and N336Q T85L, N130K, E154D, N229E, T85L, N130K, E154D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, A289P, N303S and N336Q V258G, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G and N336Q and A289P and N303S and N336Q T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, H225Y, N229E, A289P and H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, T85L, N130K, N190D, H225Y, V258G, N303S and H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q T85L, N130K, N190D, N229E, T85L, N130K, N190D, T85L, N130K, H225Y, T85L, N130K, H225Y, T85L, N130K, H225Y, A289P, N303S and N336Q V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S and N336Q and N303S N336Q and N336Q T85L, N130K, H225Y, N229E, T85L, N130K, H225Y, T85L, N130K, N229E, T85L, M134L, E154D, T85L, M134L, E154D, A289P, N303S and N336Q V258G, A289P, N303S V258G, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E and N336Q and N336Q and V258G and A289P T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, H225Y, N229E and N303S N190D, H225Y, N229E N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G and N336Q and A289P and N303S and N336Q T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, H225Y, A289P and N303S N190D, H225Y, A289P N190D, H225Y, N303S N190D, N229E, V258G N190D, N229E, V258G and N336Q and N336Q and A289P and N303S T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, N229E, V258G and N336Q N190D, N229E, A289P N190D, N229E, A289P N190D, N229E, N303S and N190D, V258G, A289P and N303S and N336Q N336Q and N303S T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, V258G, A289P and N336Q N190D, V258G, N303S N190D, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G and N336Q and N336Q and A289P and N303S T85L, M134L, E154D, H225Y, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, N229E, V258G and N336Q H225Y, N229E, A289P H225Y, N229E, A289P H225Y, N229E, N303S and H225Y, V258G, A289P and N303S and N336Q N336Q and N303S T85L, M134L, E154D, H225Y, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, V258G, A289P and N336Q H225Y, V258G, N303S H225Y, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P and N336Q and N336Q N303S and N336Q T85L, M134L, E154D, N229E, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, N190D, T85L, M134L, N190D, V258G, N303S and N336Q N229E, A289P, N303S V258G, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G and N336Q and N336Q and A289P and N303S T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, H225Y, N229E, V258G and H225Y, N229E, A289P H225Y, N229E, A289P H225Y, N229E, N303S and H225Y, V258G, A289P N336Q and N303S and N336Q N336Q and N303S T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, N190D, H225Y, V258G, A289P and H225Y, V258G, N303S H225Y, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P N336Q and N336Q and N336Q N303S and N336Q T85L, M134L, N190D, N229E, T85L, M134L, N190D, T85L, M134L, N190D, T85L, M134L, H225Y, T85L, M134L, H225Y, V258G, N303S and N336Q N229E, A289P, N303S V258G, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P and N336Q and N336Q N303S and N336Q T85L, M134L, H225Y, N229E, T85L, M134L, H225Y, T85L, M134L, H225Y, T85L, M134L, N229E, T85L, E154D, N190D, V258G, N303S and N336Q N229E, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and H225Y, N229E, V258G and N336Q and N336Q N336Q and A289P T85L, E154D, N190D, H225Y, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, N229E, V258G and N303S H225Y, N229E, V258G H225Y, N229E, A289P H225Y, N229E, A289P and H225Y, N229E, N303S and N336Q and N303S N336Q and N336Q T85L, E154D, N190D, H225Y, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, V258G, A289P and N303S H225Y, V258G, A289P H225Y, V258G, N303S H225Y, A289P, N303S and N229E, V258G, A289P and N336Q and N336Q N336Q and N303S T85L, E154D, N190D, N229E, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, N190D, T85L, E154D, H225Y, V258G, A289P and N336Q N229E, V258G, N303S N229E, A289P, N303S V258G, A289P, N303S and N229E, V258G, A289P and N336Q and N336Q N336Q and N303S T85L, E154D, H225Y, N229E, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, H225Y, T85L, E154D, N229E, V258G, A289P and N336Q N229E, V258G, N303S N229E, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S and N336Q and N336Q N336Q and N336Q T85L, N190D, H225Y, N229E, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, T85L, N190D, H225Y, V258G, A289P and N303S N229E, V258G, A289P N229E, V258G, N303S N229E, A289P, N303S and V258G, A289P, N303S and N336Q and N336Q N336Q and N336Q T85L, N190D, N229E, V258G, T85L, H225Y, N229E, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, A289P, N303S and N336Q V258G, A289P, N303S E154D, N190D, H225Y E154D, N190D, H225Y E154D, N190D, H225Y and N336Q and N229E and V258G and A289P H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, H225Y and E154D, N190D, H225Y E154D, N190D, N229E E154D, N190D, N229E E154D, N190D, N229E N303S and N336Q and V258G and A289P and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, N229E and E154D, N190D, V258G E154D, N190D, V258G E154D, N190D, V258G E154D, N190D, A289P N336Q and A289P and N303S and N336Q and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, A289P and E154D, N190D, N303S E154D, H225Y, N229E E154D, H225Y, N229E E154D, H225Y, N229E N336Q and N336Q and V258G and A289P and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, H225Y, N229E and E154D, H225Y, V258G E154D, H225Y, V258G E154D, H225Y, V258G E154D, H225Y, A289P N336Q and A289P and N303S and N336Q and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, H225Y, A289P and E154D, H225Y, N303S E154D, N229E, V258G E154D, N229E, V258G E154D, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N229E, A289P and E154D, N229E, A289P E154D, N229E, N303S E154D, V258G, A289P and E154D, V258G, A289P N303S and N336Q and N336Q N303S and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, V258G, N303S and E154D, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N336Q and N336Q and V258G and A289P and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, H225Y, N229E and N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N336Q and A289P and N303S and N336Q and N303S H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, H225Y, A289P and N190D, H225Y, N303S N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, N229E, A289P and N190D, N229E, A289P N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, V258G, N303S and N190D, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y, N229E, A289P and H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y, V258G, N303S and H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N229E, A289P, N303S and V258G, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N336Q and N336Q and V258G and A289P and N303S H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N190D, H225Y, N229E and N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N336Q and A289P and N303S and N336Q and N303S H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, 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H121Y, N130K, N190D, H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, H225Y, N229E, A289P, N303S and V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q H121Y, N130K, H225Y, H121Y, N130K, H225Y, H121Y, N130K, N229E, H121Y, M134L, E154D, H121Y, M134L, E154D, N229E, A289P, N303S and V258G, A289P, N303S V258G, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E N336Q and N336Q and N336Q and V258G and A289P H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, H225Y, N229E and N190D, H225Y, N229E N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G N303S and N336Q and A289P and N303S and N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, H225Y, A289P and N190D, H225Y, A289P N190D, H225Y, N303S N190D, N229E, V258G N190D, N229E, V258G N303S and N336Q and N336Q and A289P and N303S 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N336Q N303S and N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, N190D, H121Y, M134L, N190D, N229E, V258G, N303S and N229E, A289P, N303S V258G, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G N336Q and N336Q and N336Q and A289P and N303S H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H225Y, N229E, V258G and H225Y, N229E, A289P H225Y, N229E, A289P H225Y, N229E, N303S and H225Y, V258G, A289P N336Q and N303S and N336Q N336Q and N303S H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H225Y, V258G, A289P and H225Y, V258G, N303S H225Y, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P N336Q and N336Q and N336Q N303S and N336Q H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, N190D, H121Y, M134L, H225Y, H121Y, M134L, H225Y, N229E, V258G, N303S and N229E, A289P, N303S V258G, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P N336Q and N336Q and N336Q N303S and N336Q H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, H225Y, H121Y, M134L, N229E, H121Y, E154D, N190D, N229E, V258G, N303S and N229E, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and H225Y, N229E, V258G N336Q and N336Q and N336Q N336Q and A289P H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H225Y, N229E, V258G and H225Y, N229E, V258G H225Y, N229E, A289P H225Y, N229E, A289P and H225Y, N229E, N303S N303S and N336Q and N303S N336Q and N336Q H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H225Y, V258G, A289P and H225Y, V258G, A289P H225Y, V258G, N303S H225Y, A289P, N303S and N229E, V258G, A289P N303S and N336Q and N336Q N336Q and N303S H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, N190D, H121Y, E154D, H225Y, N229E, V258G, A289P and N229E, V258G, N303S N229E, A289P, N303S V258G, A289P, N303S and N229E, V258G, A289P N336Q and N336Q and N336Q N336Q and N303S H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, H225Y, H121Y, E154D, N229E, N229E, V258G, A289P and N229E, V258G, N303S N229E, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S N336Q and N336Q and N336Q N336Q and N336Q H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, H121Y, N190D, H225Y, N229E, V258G, A289P and N229E, V258G, A289P N229E, V258G, N303S N229E, A289P, N303S and V258G, A289P, N303S N303S and N336Q and N336Q N336Q and N336Q H121Y, N190D, N229E, H121Y, H225Y, N229E, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, V258G, A289P, N303S and V258G, A289P, N303S N190D, H225Y, N229E N190D, H225Y, N229E N190D, H225Y, N229E N336Q and N336Q and V258G and A289P and N303S N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, H225Y, N229E and N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, V258G N190D, H225Y, A289P N336Q and A289P and N303S and N336Q and N303S N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, H225Y, A289P and N190D, H225Y, N303S N190D, N229E, V258G N190D, N229E, V258G N190D, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, N229E, A289P and N190D, N229E, A289P N190D, N229E, N303S N190D, V258G, A289P N190D, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N190D, V258G, N303S and N190D, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, H225Y, N229E, A289P and H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, H225Y, V258G, N303S and H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N229E, A289P, N303S and V258G, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G N336Q and N336Q and A289P and N303S and N336Q N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, H225Y, N229E, A289P and H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, N190D, H225Y, V258G, N303S and H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q N130K, M134L, N190D, N130K, M134L, N190D, N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, H225Y, N229E, A289P, N303S and V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q N130K, M134L, H225Y, N130K, M134L, H225Y, N130K, M134L, N229E, N130K, E154D, N190D, N130K, E154D, N190D, N229E, A289P, N303S and V258G, A289P, N303S V258G, A289P, N303S H225Y, N229E, V258G H225Y, N229E, V258G N336Q and N336Q and N336Q and A289P and N303S N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, H225Y, N229E, V258G and H225Y, N229E, A289P H225Y, N229E, A289P H225Y, N229E, N303S and H225Y, V258G, A289P N336Q and N303S and N336Q N336Q and N303S N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, H225Y, V258G, A289P and H225Y, V258G, N303S H225Y, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P N336Q and N336Q and N336Q N303S and N336Q N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, N190D, N130K, E154D, H225Y, N130K, E154D, H225Y, N229E, V258G, N303S and N229E, A289P, N303S V258G, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P N336Q and N336Q and N336Q N303S and N336Q N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, H225Y, N130K, E154D, N229E, N130K, N190D, H225Y, N229E, V258G, N303S and N229E, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and N229E, V258G, A289P N336Q and N336Q and N336Q N336Q and N303S N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, H225Y, N130K, N190D, N229E, N229E, V258G, A289P and N229E, V258G, N303S N229E, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S N336Q and N336Q and N336Q N336Q and N336Q N130K, H225Y, N229E, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, V258G, A289P, N303S and H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, A289P N336Q and A289P and N303S and N336Q and N303S M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y, N229E, A289P and H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P H225Y, V258G, N303S N336Q and N336Q and N303S and N336Q and N336Q M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y, A289P, N303S and N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q M134L, E154D, N190D, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, V258G, A289P, N303S and N229E, V258G, A289P N229E, V258G, A289P N229E, V258G, N303S and N229E, A289P, N303S N336Q and N303S and N336Q N336Q and N336Q M134L, E154D, H225Y, M134L, E154D, N229E, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, V258G, A289P, N303S and V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, N229E, M134L, H225Y, N229E, E154D, N190D, H225Y, N229E, A289P, N303S and V258G, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and N229E, V258G, A289P N336Q and N336Q and N336Q N336Q and N303S E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, N229E, V258G, A289P and N229E, V258G, N303S N229E, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S N336Q and N336Q and N336Q N336Q and N336Q E154D, H225Y, N229E, N190D, H225Y, N229E, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, V258G, A289P, N303S and V258G, A289P, N303S M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, N336Q and N336Q H225Y and N229E H225Y and V258G H225Y and A289P T85L, H121Y, N130K, T85L, 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E154D, H225Y, M134L, E154D, H225Y, N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q A289P and N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, V258G, M134L, E154D, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, V258G, M134L, E154D, A289P, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, N303S and N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S T85L, H121Y, N130K, T85L, 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E154D, H225Y, N229E, E154D, H225Y, N229E, N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, N229E, A289P and E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, V258G, E154D, H225Y, V258G, N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, V258G, N303S and E154D, H225Y, A289P, E154D, N229E, V258G, E154D, N229E, V258G, E154D, N229E, V258G, N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N229E, A289P, N303S and E154D, V258G, A289P, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, H225Y, V258G, A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, V258G, N190D, H225Y, A289P, N190D, N229E, V258G, N190D, N229E, V258G, N190D, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, N229E, A289P, N190D, V258G, A289P, H225Y, N229E, V258G, H225Y, N229E, V258G, H225Y, N229E, V258G, N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, N229E, A289P, H225Y, V258G, A289P, N229E, V258G, A289P, E154D, N190D, H225Y, E154D, N190D, H225Y, N303S and N336Q N303S and N336Q N303S and N336Q N229E and V258G N229E and A289P T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, N229E and E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N303S N229E and N336Q V258G and A289P V258G and N303S V258G and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, A289P and E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, N190D, N229E, N303S A289P and N336Q N303S and N336Q V258G and A289P V258G and N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, N229E, V258G and E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, V258G, N336Q A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, V258G, A289P and E154D, N190D, V258G, E154D, N190D, A289P, E154D, H225Y, N229E, E154D, H225Y, N229E, N336Q N303S and N336Q N303S and N336Q V258G and A289P V258G and N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, N229E, V258G and E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, V258G, N336Q A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, V258G, A289P and E154D, H225Y, V258G, E154D, H225Y, A289P, E154D, N229E, V258G, E154D, N229E, V258G, N336Q N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N229E, V258G, N303S and E154D, N229E, A289P, E154D, V258G, A289P, N190D, H225Y, N229E, N190D, H225Y, N229E, N336Q N303S and N336Q N303S and N336Q V258G and A289P V258G and N303S T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, V258G and N336Q A289P and N303S A289P and N336Q N303S and N336Q A289P and N303S T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, V258G, N190D, H225Y, V258G, N190D, H225Y, A289P, N190D, N229E, V258G, N190D, N229E, V258G, A289P and N336Q N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, N229E, V258G, N190D, N229E, A289P, N190D, V258G, A289P, H225Y, N229E, V258G, H225Y, N229E, V258G, N303S and N336Q N303S and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, H121Y, M134L, T85L, H121Y, 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N190D, V258G, A289P, H225Y, N229E, V258G, N336Q N303S and N336Q N303S and N336Q N303S and N336Q A289P and N303S T85L, H121Y, E154D, H225Y, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, N229E, V258G, A289P and H225Y, N229E, V258G, H225Y, N229E, A289P, H225Y, V258G, A289P, N229E, V258G, A289P, N336Q N303S and N336Q N303S and N336Q N303S and N336Q N303S and N336Q T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, T85L, H121Y, N190D, H225Y, N229E, V258G, H225Y, N229E, V258G, H225Y, N229E, V258G, H225Y, N229E, A289P, H225Y, V258G, A289P, A289P and N303S A289P and N336Q N303S and N336Q N303S and N336Q N303S and N336Q T85L, H121Y, N190D, N229E, T85L, H121Y, H225Y, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, V258G, A289P, N303S and N229E, V258G, A289P, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N336Q N303S and N336Q N229E and V258G N229E and A289P N229E and N303S T85L, N130K, M134L, E154D, T85L, 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E154D, H225Y, N229E, E154D, H225Y, N229E, N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, N229E, A289P and E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, V258G, E154D, H225Y, V258G, N303S A289P and N336Q N303S and N336Q A289P and N303S A289P and N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, V258G, N303S and E154D, H225Y, A289P, E154D, N229E, V258G, E154D, N229E, V258G, E154D, N229E, V258G, N336Q N303S and N336Q A289P and N303S A289P and N336Q N303S and N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N229E, A289P, N303S and E154D, V258G, A289P, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N336Q N303S and N336Q V258G and A289P V258G and N303S V258G and N336Q T85L, N130K, M134L, T85L, N130K, 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V258G, A289P and N336Q N336Q N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, N229E, M134L, E154D, N229E, M134L, E154D, N229E, V258G, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N229E, M134L, E154D, V258G, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, A289P, N303S and N336Q A289P, N303S and N229E, V258G and N229E, V258G and N303S N229E, V258G and N336Q A289P N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, N229E, A289P and N303S N229E, A289P and N229E, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, N229E, M134L, N190D, N229E, M134L, N190D, N229E, V258G, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, N229E, M134L, N190D, V258G, M134L, H225Y, N229E, M134L, H225Y, N229E, M134L, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, H225Y, N229E, M134L, H225Y, V258G, M134L, N229E, V258G, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P, N303S and N336Q A289P, N303S and A289P, N303S and N229E, V258G and A289P N229E, V258G and N336Q N336Q N303S T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, V258G and N336Q N229E, A289P and N229E, A289P and N229E, N303S and N336Q V258G, A289P and N303S N336Q N303S T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, V258G, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, N190D, N229E, A289P and N336Q V258G, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, N229E, V258G, E154D, N190D, N229E, E154D, N190D, V258G, E154D, H225Y, N229E, E154D, H225Y, N229E, N303S and N336Q A289P, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, N229E, V258G, E154D, H225Y, N229E, E154D, H225Y, V258G, E154D, N229E, V258G, N190D, H225Y, N229E, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q V258G, A289P and N336Q N336Q N303S T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, V258G, A289P and N336Q V258G, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q T85L, H121Y, N130K, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, N229E, V258G, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P, N303S and N336Q N229E, V258G and N229E, V258G and N229E, V258G and N336Q N229E, A289P and A289P N303S N303S T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P and N336Q N229E, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, A289P, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, V258G, A289P, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, N303S and N336Q V258G, A289P and V258G, A289P and V258G, N303S and N336Q A289P, N303S and N303S N336Q N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, H225Y, V258G, A289P, E154D, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, E154D, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, N190D, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q V258G, A289P and N336Q N336Q N303S T85L, H121Y, E154D, N190D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, T85L, H121Y, E154D, H225Y, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, A289P and N336Q V258G, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q T85L, H121Y, E154D, H225Y, T85L, H121Y, N190D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N229E, V258G, A289P, H225Y, N229E, V258G, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N303S and N336Q A289P, N303S and N229E, V258G and N229E, V258G and N303S N229E, V258G and N336Q A289P N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P and N303S N229E, A289P and N229E, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, V258G, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, N229E, A289P, E154D, N190D, V258G, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, H225Y, N229E, A289P, E154D, H225Y, V258G, E154D, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N303S and N336Q A289P, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, V258G, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, T85L, N130K, E154D, H225Y, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q T85L, N130K, E154D, N190D, T85L, N130K, E154D, T85L, N130K, N190D, T85L, M134L, E154D, T85L, M134L, E154D, N229E, V258G, A289P, H225Y, N229E, V258G, H225Y, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N303S and N336Q A289P, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q T85L, M134L, E154D, N190D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, T85L, M134L, E154D, H225Y, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q T85L, M134L, N190D, T85L, E154D, N190D, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y, N229E, V258G, H225Y, N229E, V258G, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P, N303S and N336Q A289P, N303S and N229E, V258G and N229E, V258G and N303S N229E, V258G and N336Q A289P N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N229E, A289P and N303S N229E, A289P and N229E, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, N190D, N229E, E154D, N190D, N229E, V258G, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, N229E, E154D, N190D, V258G, E154D, H225Y, N229E, E154D, H225Y, N229E, E154D, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, H225Y, N229E, E154D, H225Y, V258G, E154D, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, V258G, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, E154D, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, V258G, A289P and N303S V258G, A289P and V258G, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q H121Y, N130K, E154D, H121Y, N130K, E154D, H121Y, N130K, N190D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, N229E, V258G, H225Y, N229E, V258G, H225Y, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and A289P, N303S and V258G, A289P and N303S V258G, A289P and N336Q N336Q N336Q H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, H121Y, M134L, E154D, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, V258G, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q H121Y, M134L, N190D, H121Y, E154D, N190D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, H225Y, N229E, V258G, H225Y, N229E, V258G, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, A289P, N303S and N336Q A289P, N303S and V258G, A289P and V258G, A289P and N336Q V258G, N303S and N336Q N303S N336Q N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, E154D, N130K, M134L, N190D, N190D, H225Y, N229E, N190D, H225Y, V258G, N190D, N229E, V258G, H225Y, N229E, V258G, H225Y, N229E, V258G, A289P, N303S and N336Q A289P, N303S and A289P, N303S and A289P, N303S and N336Q A289P, N303S and N336Q N336Q N336Q N130K, E154D, N190D, M134L, E154D, N190D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, H225Y, N229E, V258G, H225Y, N229E, V258G, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, A289P, N303S and N336Q A289P, N303S and H225Y, N229E, V258G H225Y, N229E, V258G H225Y, N229E, V258G N336Q and A289P and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y, N229E, A289P and H225Y, N229E, A289P H225Y, N229E, N303S H225Y, V258G, A289P H225Y, V258G, A289P N303S and N336Q and N336Q and N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, H225Y, V258G, N303S and H225Y, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, H225Y, N229E, A289P, N303S and V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, H225Y, M134L, E154D, H225Y, M134L, E154D, N229E, M134L, N190D, H225Y, M134L, N190D, H225Y, N229E, A289P, N303S and V258G, A289P, N303S V258G, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P N336Q and N336Q and N336Q N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, H225Y, M134L, N190D, N229E, M134L, H225Y, N229E, N229E, V258G, N303S and N229E, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S N336Q and N336Q and N336Q N336Q and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, V258G, A289P and N303S N229E, V258G, A289P N229E, V258G, N303S N229E, A289P, N303S and V258G, A289P, N303S and N336Q and N336Q N336Q and N336Q T85L, H121Y, N130K, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, N229E, V258G, E154D, H225Y, N229E, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P, N303S and N336Q V258G, A289P, N303S V258G, A289P, N303S N229E, V258G, A289P and N229E, V258G, A289P and N336Q and N336Q N303S and N336Q T85L, H121Y, M134L, E154D, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, T85L, H121Y, M134L, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, H225Y, N229E, V258G, N303S and N336Q N229E, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S and N336Q and N336Q N336Q and N336Q T85L, H121Y, M134L, T85L, H121Y, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, N229E, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, V258G, A289P, N303S and V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S N336Q and N336Q and N303S N336Q and N336Q T85L, N130K, M134L, E154D, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, T85L, N130K, M134L, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, H225Y, N229E, N190D, H225Y, N229E, A289P, N303S and N336Q V258G, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S and N336Q and N336Q N336Q and N336Q T85L, N130K, E154D, N190D, T85L, M134L, E154D, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H225Y, N229E, V258G, N190D, H225Y, N229E, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, A289P, N303S and N336Q V258G, A289P, N303S N229E, V258G, A289P N229E, V258G, A289P and N229E, V258G, N303S and N336Q and N303S N336Q and N336Q H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, H121Y, N130K, M134L, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, N229E, E154D, H225Y, N229E, N190D, H225Y, N229E, N229E, A289P, N303S and V258G, A289P, N303S V258G, A289P, N303S V258G, A289P, N303S and V258G, A289P, N303S N336Q and N336Q and N336Q N336Q and N336Q H121Y, N130K, E154D, H121Y, M134L, E154D, N130K, M134L, E154D, T85L, H121Y, N130K, T85L, H121Y, N130K, N190D, H225Y, N229E, N190D, H225Y, N229E, N190D, H225Y, N229E, M134L, E154D, N190D, M134L, E154D, N190D, V258G, A289P, N303S and V258G, A289P, N303S V258G, A289P, N303S H225Y, N229E, V258G, H225Y, N229E, V258G, N336Q and N336Q and N336Q A289P and N303S A289P and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, N130K, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, N190D, M134L, E154D, H225Y, H225Y, N229E, V258G, H225Y, N229E, A289P, H225Y, V258G, A289P, N229E, V258G, A289P, N229E, V258G, A289P, N303S and N336Q N303S and N336Q N303S and N336Q N303S and N336Q N303S and N336Q T85L, H121Y, N130K, T85L, H121Y, N130K, T85L, H121Y, M134L, T85L, N130K, M134L, H121Y, N130K, M134L, M134L, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, E154D, N190D, H225Y, N229E, V258G, A289P, N229E, V258G, A289P, N229E, V258G, A289P, N229E, V258G, A289P, N229E, V258G, A289P, N303S and N336Q N303S and N336Q N303S and N336Q N303S and N336Q N303S and N336Q T85L, H121Y, N130K, A60T, N61D, T63I, M134L, E154D, N190D, Q64K, Q64Y, F69L, H225Y, N229E, V258G, V74K, N76G, T85L, A289P, N303S and D112E, K115E, R116N, N336QA60T, Q64Y, F69L, E119K, E120K, H121Y, D112E, K115E, R116N, N130K, M134L, N145D, E119K, E120K, N145D, H146S, E154D, N190D, H146S, E198R, S223N, E198R, S223N, H225Y, N231T, K241Q, L251I, S273A, F227L, N229E, E229N, N274E, K278E, A303N, N231T, K241Q, L251I, K314E, and S334IA60T, V258G, S273A, N274E, N61D, T63I, Q64Y, Q64K, K278E, A289P, A303N, F69L, V74K, N76G, D112E, K314E, S334I, and K115E, R116N, E119K, N336Q E120K, N145D, H146S, E198R, S223N, F227L, E229N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I

[0117] In some embodiments, the polypeptides comprise a variant protease provided for herein are 50, 60, 70, 80, 85, 90, 91 92, 93, 94, 95, 96, 97, 98, or 99% identical to the reference protease (SEQ ID NOs: 35, 55-1019, 1290-1310 and 1333; 1023-1289, 1311-1329, or 1334-1336) and comprise a mutation set herein, such as in the table above, or the groupings below. In some embodiments in addition to the mutation set of such reference sequences, the variant protease, comprises a cysteine (C) at the position in said variant sequence which corresponds to position 94 of SEQ ID NO: 35; and/or has, at the positions in said variant sequence which correspond to positions 84, 262, 284 and 286 of SEQ ID NO: 35, a lysine (K), a histidine (H), an aspartic acid (D) and/or an aspartic acid (D), respectively. In some embodiments, the polypeptide comprises a lysine (K) at position 115 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises or further comprises an asparagine (N) at position 130 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an asparagine (N) at position 336 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a glutamine (Q) at position 337 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises threonine (T) at position 338 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an asparagine (N) at position 339 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a glycine (G) at position 130 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an asparagine (N) at position 284 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises an asparagine (N) at position 286 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a lysine (K) at position 130 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a glycine (G) at position 261 as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a glycine (G) at position 258 as compared to SEQ ID NO: 35.

[0118] In some embodiments, the polypeptide comprises any one, or any combination of K115K, N130N, N336N, Q337Q, T338T, N339N, N130G, D284N, D286N, N130K, N261G, and V258G, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises any one set of: K115K, N130N, N336N, Q337Q, T338T, and N339N as compared to SEQ ID NO: 35; K115K, N130G, N336N, Q337Q, T338T, and N339N as compared to SEQ ID NO: 35; D284N as compared to SEQ ID NO: 35; D286N as compared to SEQ ID NO: 35; N130K, and D284N as compared to SEQ ID NO: 35; N130K, and D286N as compared to SEQ ID NO: 35; K115K, N130N, N336N, Q337Q, T338T, N339N, and N261G as compared to SEQ ID NO: 35; K115K, N130G, N336N, Q337Q, T338T, N339N, and N261G as compared to SEQ ID NO: 35; D284N, and N261G as compared to SEQ ID NO: 35; D286N, and N261G as compared to SEQ ID NO: 35; N130K, D284N, and N261G as compared to SEQ ID NO: 35; N130K, D286N, and N261G as compared to SEQ ID NO: 35; K115K, N130N, N336N, Q337Q, T338T, N339N, and V258G as compared to SEQ ID NO: 35; K115K, N130G, N336N, Q337Q, T338T, N339N, and V258G as compared to SEQ ID NO: 35; D284N, and V258G as compared to SEQ ID NO: 35; D286N, and V258G as compared to SEQ ID NO: 35; N130K, D284N, and V258G as compared to SEQ ID NO: 35; N130K, D286N, V258G as compared to SEQ ID NO: 35; or N130K, and N261G as compared to SEQ ID NO: 35.

[0119] In some embodiments, the protease comprises a lysine (K) at position 115 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises an asparagine (N) at position 130 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises an asparagine (N) at position 336 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises a glutamine (Q) at position 337 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises threonine (T) at position 338 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises an asparagine (N) at position 339 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises a glycine (G) at position 130 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises an asparagine (N) at position 284 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises an asparagine (N) at position 286 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises a lysine (K) at position 130 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises a glycine (G) at position 261 as compared to SEQ ID NO: 35. In some embodiments, the protease comprises a glycine (G) at position 258 as compared to SEQ ID NO: 35.

[0120] In some embodiments, the protease comprises any one, or any combination of K115K, N130N, N336N, Q337Q, T338T, N339N, N130G, D284N, D286N, N130K, N261G, and V258G, as compared to SEQ ID NO: 35. In some embodiments, the protease comprises any one set of: K115K, N130N, N336N, Q337Q, T338T, and N339N as compared to SEQ ID NO: 35; K115K, N130G, N336N, Q337Q, T338T, and N339N as compared to SEQ ID NO: 35; D284N as compared to SEQ ID NO: 35; D286N as compared to SEQ ID NO: 35; N130K, and D284N as compared to SEQ ID NO: 35; N130K, and D286N as compared to SEQ ID NO: 35; K115K, N130N, N336N, Q337Q, T338T, N339N, and N261G as compared to SEQ ID NO: 35; K115K, N130G, N336N, Q337Q, T338T, N339N, and N261G as compared to SEQ ID NO: 35; D284N, and N261G as compared to SEQ ID NO: 35; D286N, and N261G as compared to SEQ ID NO: 35; N130K, D284N, and N261G as compared to SEQ ID NO: 35; N130K, D286N, and N261G as compared to SEQ ID NO: 35; K115K, N130N, N336N, Q337Q, T338T, N339N, and V258G as compared to SEQ ID NO: 35; K115K, N130G, N336N, Q337Q, T338T, N339N, and V258G as compared to SEQ ID NO: 35; D284N, and V258G as compared to SEQ ID NO: 35; D286N, and V258G as compared to SEQ ID NO: 35; N130K, D284N, and V258G as compared to SEQ ID NO: 35; N130K, D286N, V258G as compared to SEQ ID NO: 35; or N130K, and N261G as compared to SEQ ID NO: 35.

[0121] In some embodiments, the polypeptide comprises or further comprises a mutation at any one position, or any combination of positions, selected from 130, 131, 198, 216, 302, 119, 244, 142, 115, 241, 245, 316, 333, 139, as compared to SEQ ID NO: 35. In some embodiments, the polypeptide comprises a positively charged amino acid at position 130, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the polypeptide comprises a positively charged amino acid at position 131, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the polypeptide comprises a positively charged amino acid at position 130, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and wherein the polypeptide comprises a positively charged amino acid at position 131, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K).

[0122] In some embodiments, the polypeptide comprises any one mutation, or any set of mutations, selected from N130K, E198R, D216N, N130R, E198K, S302K, E119R, T244D, E119K, D142R, T244E, K115E, K241E, E245K, D316K, D333K, K241S, E245N, E139K. In some embodiments, the polypeptide comprises any set of mutations selected from: [0123] N130K, E198R, and D216N; N130R, E198K, D216N, and S302K; E119R, D216N, and T244D; E119K, D142R, D216N, T244E, and S302K; K115E, D216N, K241E, E245K, D316K, and D333K; E119K, N130R, D142R, D216N, K241S, T244E, E245N, and S302K; E119K, N130R, D142R, E198K, D216N, and T244E; and K115E, N130R, E198K, D216N, K241E, E245K, and D333K.

[0124] In some embodiments, the polypeptide comprises a mutation at any one position, or any combination of positions, selected from 84, 93, 95, 97, 137, 140, 147, 150, 162, 165, 166, 171, 174, 205, 226, 237, 239, 243, 250, 251, 254, 255, 282, 288, 312, 315, 347, 349, as compared to SEQ ID NO: 1331 or 1332. In some embodiments, the polypeptide comprises a positively charged amino acid at position 138, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the polypeptide comprises a positively charged amino acid at position 139, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the polypeptide comprises a positively charged amino acid at position 138, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and wherein the polypeptide comprises a positively charged amino acid at position 139, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K).

[0125] In some embodiments, the polypeptide comprises any one mutation, or any set of mutations, selected from H84N, A93T, D95N, K97A, F137I, Q140E, A147E, D150R, N162E, R165K, D166E, N171Y, A174T, N205K, D226N, L237F, N239E, N243K, K250S, Q251E, T254E, E255K, N282D, E288K, A312K, H315K, K347Q, S349N. In some embodiments, the polypeptide comprises any set of mutations selected from: H84N, N138R, A147E, D150R, N162E, N171Y, N205K, D226N, Q251E, E255K, A312K, and S349N; A93T, D95N, Q140E, R165K, D166E, A174T, D226N, L237F, N239E, N243K, N282D, E288K, H315K, and K347Q; R70T, N72Q, and N73G; R70T, N72Q, N73G, H84N, N138R, N162E, N205K, and D226N; R70T, N72Q, N73G, N138R, and D226N; R70T, N72Q, N73G, K97A, N138R, and D226N; and R70T, N72Q, N73G, N138R, and D226N.

[0126] In some embodiments, the protease comprises a mutation at any one position, or any combination of positions, selected from 130, 131, 198, 216, 302, 119, 244, 142, 115, 241, 245, 316, 333, 139, as compared to SEQ ID NO: 35. In some embodiments, the protease comprises a positively charged amino acid at position 130, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the protease comprises a positively charged amino acid at position 131, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the protease comprises a positively charged amino acid at position 130, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and wherein the protease comprises a positively charged amino acid at position 131, as compared to SEQ ID NO: 35, optionally wherein said positively charged amino acid is arginine (R) or lysine (K).

[0127] In some embodiments, the protease comprises any one mutation, or any set of mutations, selected from N130K, E198R, D216N, N130R, E198K, S302K, E119R, T244D, E119K, D142R, T244E, K115E, K241E, E245K, D316K, D333K, K241S, E245N, E139K. In some embodiments, the protease comprises any set of mutations selected from: N130K, E198R, and D216N; N130R, E198K, D216N, and S302K; E119R, D216N, and T244D; E119K, D142R, D216N, T244E, and S302K; K115E, D216N, K241E, E245K, D316K, and D333K; E119K, N130R, D142R, D216N, K241S, T244E, E245N, and S302K; E119K, N130R, D142R, E198K, D216N, and T244E; and K115E, N130R, E198K, D216N, K241E, E245K, and D333K.

[0128] In some embodiments, the protease comprises a mutation at any one position, or any combination of positions, selected from 84, 93, 95, 97, 137, 140, 147, 150, 162, 165, 166, 171, 174, 205, 226, 237, 239, 243, 250, 251, 254, 255, 282, 288, 312, 315, 347, 349, as compared to SEQ ID NO: 1331 or 1332. In some embodiments, the protease comprises a positively charged amino acid at position 138, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the protease comprises a positively charged amino acid at position 139, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K). In some embodiments, the protease comprises a positively charged amino acid at position 138, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and wherein the protease comprises a positively charged amino acid at position 139, as compared to SEQ ID NO: 1331 or 1332, optionally wherein said positively charged amino acid is arginine (R) or lysine (K).

[0129] In some embodiments, the protease comprises any one mutation, or any set of mutations, selected from H84N, A93T, D95N, K97A, F137I, Q140E, A147E, D150R, N162E, R165K, D166E, N171Y, A174T, N205K, D226N, L237F, N239E, N243K, K250S, Q251E, T254E, E255K, N282D, E288K, A312K, H315K, K347Q, S349N. In some embodiments, the protease comprises any set of mutations selected from: H84N, N138R, A147E, D150R, N162E, N171Y, N205K, D226N, Q251E, E255K, A312K, and S349N; A93T, D95N, Q140E, R165K, D166E, A174T, D226N, L237F, N239E, N243K, N282D, E288K, H315K, and K347Q; R70T, N72Q, and N73G; R70T, N72Q, N73G, H84N, N138R, N162E, N205K, and D226N; R70T, N72Q, N73G, N138R, and D226N; R70T, N72Q, N73G, K97A, N138R, and D226N; and R70T, N72Q, N73G, N138R, and D226N.

[0130] In some embodiments, the polypeptide comprises any mutation, or set of mutation, as provided in PCT Publication Nos. WO2016128558, and WO2016128559, or U.S. Pat. Nos. 10,696,959, 11,214,784, 10,758,597, or 11,524,057, each of which is hereby incorporated by reference in its entirety.

[0131] IdeS (Immunoglobulin G-degrading enzyme of Streptococcus pyogenes) is an enzyme derived from the bacterium Streptococcus pyogenes that cleaves IgG antibodies and has been explored for its potential therapeutic applications, particularly in the field of transplantation immunology. The immunogenicity of IdeS is a significant consideration for its clinical use, as the human immune system can potentially recognize the enzyme as a foreign protein and generate an immune response. This response could lead to the production of anti-drug antibodies (ADAs) that may neutralize the enzymatic activity of IdeS or alter its pharmacokinetics, potentially reducing its efficacy or increasing the risk of adverse effects. Furthermore, repeated administration of IdeS could enhance this immunogenic response, limiting its long-term utility in chronic conditions. Thus, for any given subject, the problems associated with the immunogenicity of IdeS are likely to present a barrier to the use of IdeS as a treatment. These problems may require increases to the dose of IdeS and/or preclude treatment with IdeS entirely, particularly if repeat administrations are required.

[0132] Existing approaches to problems of this type involve, for example, PEGylation of a therapeutic agent to reduce immunogenicity or co-administration of the therapeutic agent with an immune-suppressive agent. Some other approaches involve identification of specific positions within the sequence of IdeS which, when modified, lead to polypeptides for which the problems associated with immunogenicity are reduced as compared to IdeS. Thus, some modifications may increase the efficacy at cleaving IgG of the polypeptide of the disclosure relative to IdeS, thereby indirectly reducing immunogenicity by permitting the use of a lower dose or concentration to achieve the same effect. Alternatively, or in addition, other modifications may directly reduce immunogenicity by reducing the ability of IdeS-specific antibodies to recognise the polypeptide of the disclosure relative to IdeS.

[0133] The present disclosure provides IdeS variants that have, amongst other properties, lower immunogenicity as compared to wild-type IdeS. This can enable the variants to be administered to patients more than one time. The variants provided herein, can also comprises mutations or changes as compared to the wild-type sequence that impact post-translational modifications, aggregation, glycosylation, impurities, and formulation components), reduce B cell epitopes, thereby reducing the likelihood for creating antibody epitopes that would be produce antibodies in vivo against the variants, reduce T cell epitopes (linear peptide sequences that can be displayed on MHCII and lead to de novo immune responses), and reduce the likelihood of ADA (anti-drug antibodies). Thus, in some embodiments, a polypeptide having an IgG protease activity has one more B cell epitopes removed. In some embodiments, a polypeptide having an IgG protease activity has one or more T cell epitopes removed. In some embodiments, a polypeptide having an IgG protease activity does not have, or does not have significant, chemical liabilities. In some embodiments, a polypeptide having an IgG protease activity has one or more B cell epitopes removed, one more T cell epitopes removed, and does not have, or does not have significant, chemical liabilities. Without being bound to any particular theory, a polypeptide having an IgG protease activity, such as those provided herein, can be utilized in a way that can be administered more than once, and thus can be used in a non-dose limiting manner or method.

[0134] In some embodiments, the polypeptide having IgG protease activity is as effective, or more effective at cleaving IgG than the wild-type protease, and/or is less immunogenic as the wild-type protease. In some embodiments, the polypeptide having IgG protease activity is as effective at cleaving IgG as compared to the wild-type protease. In some embodiments, the polypeptide having IgG protease activity is more effective at cleaving IgG than the wild-type protease. In some embodiments, the polypeptide having IgG protease activity is less effective at cleaving IgG than the wild-type protease, but is also less immunogenic and/or has fewer chemical liabilities as compared to the wild-type protease. This properties can be as compared to the wild-type IdeS or the wild-type Ides that is fused to a Fc molecule, such as those provided for herein. In some embodiments, the polypeptide having IgG protease activity is less immunogenic than the wild-type protease. In some embodiments, the polypeptide having IgG protease activity is as immunogenic as the wild-type protease.

[0135] Immunogenicity can be measured by any assay, such as the one the described in Example 15. For example, immunogenicity of a variant, fused to Fc or not, can be compared to wild-type IdeS (fused to Fc or not), provided that the comparison between the variant molecule and the wild-type IdeS molecule is the same type of molecule (fused to Fc or not), by evaluating for pre-existing antibody binding the variant in human donor cells, such as PBMCs, which can be measured through an electrochemiluminescence (ECL) immunoassay. This is one exemplary method and other methods can also be used.

[0136] In some embodiments, the polypeptide having IgG protease activity is as effective, or more effective at cleaving IgG than the wild-type IdeS, and/or is less immunogenic, or as immunogenic, as the wild-type IdeS. In some embodiments, the polypeptide having IgG protease activity is as effective at cleaving IgG than the wild-type IdeS. In some embodiments, the polypeptide having IgG protease activity is more effective at cleaving IgG than the wild-type IdeS. In some embodiments, the polypeptide having IgG protease activity is less immunogenic than the wild-type IdeS. In some embodiments, the polypeptide having IgG protease activity is as immunogenic as the wild-type IdeS.

[0137] In some embodiments, PRT-1 through PRT-719 is as effective, or more effective at cleaving IgG than the wild-type protease, and/or is less immunogenic, or as immunogenic, as the wild-type protease. In some embodiments, PRT-1 through PRT-719 is as effective at cleaving IgG than the wild-type protease. In some embodiments, PRT-1 through PRT-719 is more effective at cleaving IgG than the wild-type protease. In some embodiments, PRT-1 through PRT-719 is less immunogenic than the wild-type protease. In some embodiments, PRT-1 through PRT-719 is as immunogenic as the wild-type protease.

[0138] In some embodiments, PRT-1 through PRT-719 is as effective, or more effective at cleaving IgG than the wild-type protease, and/or is less immunogenic, or as immunogenic, as the wild-type IdeS. In some embodiments, PRT-1 through PRT-719 is as effective at cleaving IgG than the wild-type IdeS. In some embodiments, PRT-1 through PRT-719 is more effective at cleaving IgG than the wild-type IdeS. In some embodiments, PRT-1 through PRT-719 is less immunogenic than the wild-type IdeS. In some embodiments, PRT-1 through PRT-719 is as immunogenic as the wild-type IdeS.

[0139] In some embodiments, VRT-1 through VRT-319 is as effective, or more effective at cleaving IgG than the wild-type protease, and/or is less immunogenic, or as immunogenic, as the wild-type protease. In some embodiments, VRT-1 through VRT-319 is as effective at cleaving IgG than the wild-type protease. In some embodiments, VRT-1 through VRT-319 is more effective at cleaving IgG than the wild-type protease. In some embodiments, VRT-1 through VRT-319 is less immunogenic than the wild-type protease. In some embodiments, VRT-1 through VRT-319 is as immunogenic as the wild-type protease.

[0140] In some embodiments, VRT-1 through VRT-319 is as effective, or more effective at cleaving IgG than the wild-type protease, and/or is less immunogenic, or as immunogenic, as the wild-type IdeS. In some embodiments, VRT-1 through VRT-319 is as effective at cleaving IgG than the wild-type IdeS. In some embodiments, VRT-1 through VRT-319 is more effective at cleaving IgG than the wild-type IdeS. In some embodiments, VRT-1 through VRT-319 is less immunogenic than the wild-type IdeS. In some embodiments, VRT-1 through VRT-319 is as immunogenic as the wild-type IdeS.

Fc Fusion Molecules

[0141] Provided herein are therapeutic compounds, e.g., therapeutic protein molecules, e.g., fusion proteins, including an effector binding/modulating moiety and a polypeptide having protease activity. Also provided are methods of using and making the therapeutic compounds. In some embodiments, the effector binding/modulating moiety is a variant Fc polypeptide, such as, but not limited to, those provided herein.

[0142] The disclosure provides for, for example, a polypeptide comprising a polypeptide having protease activity and a Fc polypeptide domain, wherein the polypeptide having protease activity is covalently or non-covalently connected to the Fc polypeptide domain. In some embodiments, the Fc polypeptide domain is a variant Fc polypeptide, such as those provided herein. Accordingly, in some embodiments, a polypeptide comprising a polypeptide having protease activity and a Fc polypeptide domain is provided, wherein the polypeptide having protease activity is covalently or non-covalently connected to the Fc polypeptide, is provided. The polypeptide having protease activity can be fused or linked (i.e., conjugated) to the Fc polypeptide. In some embodiments, the polypeptide having protease activity is non-covalently associated with the Fc polypeptide domain.

[0143] In some embodiments, the Fc polypeptide domain is an IgG Fc polypeptide, such as a Fc polypeptide that is, or derived from an IgG1, IgG2, IgG3, or IgG4 Fc polypeptide. In some embodiments, the Fc polypeptide domain is a variant Fc polypeptide domain, such as the variants provided for herein. In some embodiments, the Fc polypeptide domain is protease resistant. The Fc polypeptide can be resistant to protease to which it is connected to, thus resistant to protease cleavage and/or binding by the protease. In some embodiments, the variant Fc polypeptide, such as those provided herein, comprises a mutation that renders the IgG Fc polypeptide resistant to cleavage by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, comprises a mutation that renders the IgG Fc polypeptide resistant to binding by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, comprises a set of mutations that render the IgG Fc polypeptide resistant to cleavage by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, comprises a set of mutations that render the IgG Fc polypeptide resistant to binding by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, comprises a mutation that renders the IgG Fc polypeptide resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, comprises a set of mutations that render the IgG Fc polypeptide resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, is resistant to cleavage by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, is resistant to binding by a protease, or a variant thereof. In some embodiments, the variant Fc polypeptide, such as those provided herein, is resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof. It can also be resistant to other proteases that the Fc polypeptide domain is not connected to. Fc polypeptides can self-associate with one another to form a dimer. The dimer can be a homodimer where the Fc polypeptide is the same in each polypeptide molecule or can be a heterodimer where the Fc polypeptide is different in each polypeptide molecule that forms the dimer.

[0144] In some embodiments, the protease resistant Fc domain is resistant to cleavage by an IdeS protease, or variant thereof. In some embodiments, wherein the protease resistant Fc domain is completely resistant to cleavage by an IdeS protease, or a variant thereof. In some embodiments, wherein the protease resistant Fc domain is about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98%, about 99%, or about 100% resistant to cleavage by an IdeS protease, or a variant thereof. In some embodiments, wherein the protease resistant Fc domain is completely resistant to cleavage by an IdeS protease, or a variant thereof. In some embodiments, wherein the protease resistant Fc domain is 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% resistant to cleavage by an IdeS protease, or a variant thereof. In some embodiments, the protease resistant Fc domain is resistant to cleavage by an IdeS protease, or variant thereof, as compared to the wild-type Fc domain. In some embodiments, wherein the protease resistant Fc domain is completely resistant to cleavage by an IdeS protease, or a variant thereof, as compared to the wild-type Fc domain. In some embodiments, wherein the protease resistant Fc domain is about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98%, about 99%, or about 100% resistant to cleavage by an IdeS protease, or a variant thereof, as compared to the wild-type Fc domain. In some embodiments, wherein the protease resistant Fc domain is completely resistant to cleavage by an IdeS protease, or a variant thereof. In some embodiments, wherein the protease resistant Fc domain is 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% resistant to cleavage by an IdeS protease, or a variant thereof, as compared to the wild-type Fc domain. In some embodiments, the protease resistant Fc domain is resistant to cleavage by an IdeS protease, or variant thereof, as compared to an Fc domain that does not comprise any one or all mutations of SEQ ID NO: 23. In some embodiments, wherein the protease resistant Fc domain is completely resistant to cleavage by an IdeS protease, or a variant thereof, as compared to an Fc domain that does not comprise any one or all mutations of SEQ ID NO: 23. In some embodiments, wherein the protease resistant Fc domain is about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 91%, about 92%, about 93%, about 94%, about 95%, about 96%, about 97%, about 98%, about 99%, or about 100% resistant to cleavage by an IdeS protease, or a variant thereof, as compared to an Fc domain that does not comprise any one or all mutations of SEQ ID NO: 23. In some embodiments, wherein the protease resistant Fc domain is completely resistant to cleavage by an IdeS protease, or a variant thereof. In some embodiments, wherein the protease resistant Fc domain is 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% resistant to cleavage by an IdeS protease, or a variant thereof, as compared to an Fc domain that does not comprise any one or all mutations of SEQ ID NO: 23.

[0145] In some embodiments, the variant Fc polypeptide is covalently or non-covalently conjugated to a polypeptide having IgG protease activity, wherein the polypeptide having IgG protease activity can be conjugated to N-terminus or C-terminus of the variant Fc polypeptide. In some embodiments, the variant Fc polypeptide is covalently or non-covalently conjugated to a polypeptide having IgG protease activity, wherein the polypeptide having IgG protease activity can be conjugated to the N-terminus of the variant Fc polypeptide. In some embodiments, the variant Fc polypeptide is covalently or non-covalently conjugated to a polypeptide having IgG protease activity, wherein the polypeptide having IgG protease activity can be conjugated to the C-terminus of the variant Fc polypeptide.

[0146] The Fc polypeptide and the polypeptide having protease activity can be physically tethered, covalently or non-covalently, directly or through a linker entity, to one another, e.g., as a domain of the same linear primary amino acid sequence in a single polypeptide. The polypeptides can associate with one another through the Fc polypeptide, such that a dimer is created having a first and second polypeptide. In some embodiments, the first polypeptide comprises a polypeptide having protease activity linked to a Fc polypeptide domain. In some embodiments, the second polypeptide comprises a Fc polypeptide domain, such as those provided for herein. In some embodiments, the second polypeptide does not comprise a protease domain. In some embodiments, the second polypeptide comprises a protease domain.

[0147] This multi-domain molecule can be referred to as a therapeutic protein molecule. In some embodiments, the protease and the IgG Fc molecule are provided in a therapeutic protein molecule, e.g., a fusion protein.

[0148] In some embodiments, polypeptide comprising the polypeptide having protease activity, the Fc polypeptide domain, which can be a variant Fc polypeptide, or both further comprises a single domain antibody molecule, e.g., a nanobody, a camelid antibody VHH molecule or human soluble VH domain. Without wishing to be bound to any particular theory, the nanobody covalently or non-covalently conjugated to the polypeptide comprising a polypeptide having a protease activity and/or an Fc polypeptide may extend the half-life of the polypeptide. In some embodiments, the single domain antibody molecule, e.g., a nanobody, a camelid antibody VHH molecule or human soluble VH domain is physically tethered, covalently or non-covalently, directly or through a linker entity, to the polypeptide having protease activity, the variant Fc polypeptide, or both. In some embodiments, the variant Fc polypeptide may also contain a single-chain fragment variable (scFv) or a Fab domain. In some embodiments, the therapeutic protein molecule, or a nucleic acid, e.g., an mRNA or DNA, encoding the therapeutic protein molecule, can be administered to a subject. In some embodiments, the polypeptide having protease activity and the variant Fc polypeptide are linked to a third entity, e.g., a carrier, e.g., a polymeric carrier, a dendrimer, or a particle, e.g., a nanoparticle. As used herein, the terms nanobody, and VHH can be used interchangeably.

[0149] Non-limiting examples of nanobodies include those provided in McMahon et al., Nat Struct Mol Biol. 2018 March; 25(3): 289-296. doi:10.1038/s41594-018-0028-6; which is hereby incorporated by reference in its entirety. In some embodiments, the nanobody, or the VHH comprises an amino acid sequence as set in Table 6.

TABLE-US-00011 TABLE6 ID VHHSeq VHH- QVQLQESGGLVQAGGSLRLSCAASGYISDAYYMGWYRQAPGKER 1 EFVATITHGTNTYYADSVKGRFTISRDNAKNTVYLQMNSLKPED TAVYYCAVLETRSYSFRYWGQGTQVTVSSLEGGGGS(SEQID NO:30) VHH- QVQLQESGGGLVQAGGSLRLSCAASGYISDAYYMGWYRQAPGKE 2 REFVATITHGTNTYYADSVKGRFTISRDNAKNTVYLQMNSLKPE DTAVYYCAVLETRSYSFRYWGQGTQVTVSSLEGG(SEQID NO:32) VHH- QVQLQESGGGLVQAGGSLRLSCAASGYISDAYYMGWYRQAPGKE 3 REFVATITHGTNTYYADSVKGRFTISRDNAKNTVYLQMNSLKPE DTAVYYCAVLETRSYSFRYWGQGTQVTVSSLE(SEQIDNO: 33)

[0150] In some embodiments, a nanobody comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to any sequence provided in Table 6. In some embodiments, a nanobody comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 30, 32, or 33. In some embodiments, a nanobody comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 30. In some embodiments, a nanobody comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 32. In some embodiments, a nanobody comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 33.

[0151] In some embodiments, a nanobody comprises an amino acid sequence having an amino acid sequence of SEQ ID NO: 30, 32, or 33. In some embodiments, a nanobody comprises an amino acid sequence having an amino acid sequence of SEQ ID NO: 30. In some embodiments, a nanobody comprises an amino acid sequence having an amino acid sequence of SEQ ID NO: 32. In some embodiments, a nanobody comprises an amino acid sequence having an amino acid sequence of SEQ ID NO: 33.

[0152] In some embodiments, a therapeutic compound or compound comprises a polypeptide comprising a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide. In some embodiments, a therapeutic molecule comprises a fusion protein comprising a polypeptide having protease activity fused, e.g., directly or through a linking moiety comprising one or more amino acid residues, to a variant Fc polypeptide. In some embodiments, a therapeutic compound or compound comprises a polypeptide comprising a polypeptide having protease activity linked by a non-covalent bond or a covalent bond, e.g., a covalent bond other than a peptide bond, e.g., a sulfhydryl bond, to a variant Fc polypeptide.

[0153] In some embodiments, the protease is an IgG cleaving protease. In some embodiments, the IgG cleaving protease is selected from IdeS, IdeSsuis, IdeE, IdeZ, IdeE2, IdeZ2, Ide85, and IdeC. In some embodiments, the IgG cleaving protease is IdeS. In some embodiments, the IgG cleaving protease is IdeSsuis. In some embodiments, the IgG cleaving protease is IdeE. In some embodiments, the IgG cleaving protease is IdeZ. In some embodiments, the IgG cleaving protease is IdeE2. In some embodiments, the IgG cleaving protease is IdeZ2. In some embodiments, the IgG cleaving protease is Ide85. In some embodiments, the IgG cleaving protease is IdeC. The IgG protease can be a variant protease of any of the foregoing. Examples of IgG proteases and variant proteases include, but are not limited to, those that are described in WO2003051914, WO2006131347, WO2016128558, WO2016128559, WO2016012285, WO2008071418, WO2012119983, WO2010057626, WO2015184325, WO2021026264, WO2021021989, WO2018034346, WO2010089126, WO200908027, WO2008136735, WO2015181356, WO2018093868, WO2013037824, WO2017134274, WO2016046220, WO2015040125, WO2009033670, WO2004096157, WO2010123885, WO2010118337, WO2019075360, WO2007019376, and U.S. Pat. No. 10,836,815, each of which are hereby incorporated by reference in their entirety. Non-limiting examples of proteases include, but are not limited to proteases comprise an amino acid sequence having at least 50%, 60%, 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to, or is identical to, a sequence provided in Table 4, Table 5, Table 7, or Table 8.

[0154] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to the N-terminus of a variant Fc polypeptide. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to the C-terminus of a variant Fc polypeptide. In some embodiments, there can be a linker moiety, such as a peptide moiety or a non-peptide linkage, between the polypeptide having protease activity and the N-terminus or the C-terminus of the Fc polypeptide.

[0155] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a nanobody and a variant Fc polypeptide, wherein the C-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of a nanobody, and the N-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the C-terminus of a variant Fc polypeptide. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a nanobody and a variant Fc polypeptide, wherein the N-terminus of a polypeptide having protease activity is covalently or non-covalently conjugated to the C-terminus of a nanobody, and the C-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of a variant Fc polypeptide. In some embodiments, the polypeptide having protease activity is as provided herein. In some embodiments, the variant IgG Fc is as provided herein. In some embodiments, the nanobody is as provided herein.

[0156] In some embodiments, a polypeptide comprising a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide further comprises a tag, such as a purification tag or detection tag. The tag can be used to facilitate the purification, isolation, or detection of the polypeptide. A non-limiting example of such a tag is a histidine tag, which is a plurality of histidines (e.g., 6 or more histidines). In some embodiments, a polypeptide comprising a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide further comprises a histidine tag, wherein the C-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of a variant Fc polypeptide, and wherein the C-terminus of the variant Fc polypeptide is covalently or non-covalently conjugated to the N-terminus of the tag. In some embodiments, a polypeptide comprising a polypeptide having protease activity covalently or non-covalently conjugated to a nanobody and a variant Fc polypeptide further comprises a tag. In some embodiments, a polypeptide comprising a polypeptide having protease activity covalently or non-covalently conjugated to a nanobody and a variant Fc polypeptide further comprises a tag, wherein the N-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the C-terminus of the nanobody, wherein the C-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of a variant Fc polypeptide, and wherein the C-terminus of the variant Fc polypeptide is covalently or non-covalently conjugated to the N-terminus of the tag. In some embodiments, a polypeptide comprising a polypeptide having protease activity covalently or non-covalently conjugated to a nanobody and a variant Fc polypeptide further comprises a histidine tag, wherein the N-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the C-terminus of a variant Fc polypeptide, wherein the C-terminus of the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of the nanobody, and wherein the C-terminus of the nanobody is covalently or non-covalently conjugated to the N-terminus of the tag.

[0157] In some embodiments, the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to a sequence provided in Table 3. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical to SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to, or is identical to, SEQ ID NO: 23.

[0158] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to a sequence provided in Table 3, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0159] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to a sequence provided in Table 3, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0160] As used herein, the positions referenced in the Fc polypeptides as positions for a mutation refer to EU numbering system. The Fc polypeptides can aligned with a wild-type sequence to determine the positions that are mutated according to the numbering system.

[0161] As used herein in reference to a polypeptide that has a % identity to a reference sequence and further comprises a mutation at one or more positions, means a polypeptide that has the recited % identity to the reference sequence and also has one or more of the mutations at the recited positions.

[0162] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0163] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0164] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0165] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0166] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0167] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0168] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0169] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence as provided in Table 3.

[0170] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 47, 48, or 49. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 20. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 21. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 22. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 24. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 25. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 42. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 43. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 44. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 45. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 46. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 47. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 48. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 49.

[0171] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having a C-terminal lysine (K). In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence that does not have (comprise) a C-terminal lysine (K).

[0172] In some embodiments, the protease present in the polypeptides provided for herein comprise an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to, or is identical to, a sequence provided in Table 4, Table 5, Table 7, or Table 8, wherein the protease is covalently or non-covalently conjugated to a variant Fc polypeptide, and wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3.

[0173] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, and wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 47, 48, or 49.

[0174] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, and the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23.

[0175] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0176] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0177] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0178] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0179] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0180] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0181] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 4, Table 5, Table 7, or Table 8, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0182] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0183] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations at position 234, 235, 237, 296, 329, or any combination thereof.

[0184] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 4, Table 5, Table 7, or Table 8, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0185] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0186] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations at position L234, L235, G237, Y296, P329, or any combination thereof.

[0187] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0188] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0189] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 4, Table 5, Table 7, or Table 8, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 3, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0190] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0191] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0192] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23, and further comprises one or more mutations of L234A, L235A, G237A, Y296Q, P329K, or any combination thereof.

[0193] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence as provided in Table 3. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 20. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 21. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 22. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 24. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 25. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 42. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 43. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 44. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 45. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 46. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 47. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 48. In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 49.

[0194] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising any sequence provided in Table 4, Table 5, Table 7, or Table 8, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence as provided in Table 3. In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence of SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49.

[0195] In some embodiments, a polypeptide comprises a polypeptide having protease activity comprising an amino acid sequence of SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23.

[0196] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence having a C-terminal lysine (K).

[0197] In some embodiments, a polypeptide comprises a polypeptide having protease activity covalently or non-covalently conjugated to a variant Fc polypeptide, wherein the variant Fc polypeptide comprises an amino acid sequence not having a C-terminal lysine (K).

[0198] In some embodiments, a histidine tag comprises an amino acid sequence of SEQ ID NO: 27, or 34. In some embodiments, the histidine tag comprises an amino acid sequence of SEQ ID NO: 27. In some embodiments, the histidine tag comprises an amino acid sequence of SEQ ID NO: 34.

[0199] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

P1---variant Fc,

wherein, [0200] P1 comprises a polypeptide having protease activity; and [0201] variant Fc is any variant IgG Fc provided herein.

[0202] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

variant Fc---P1,

wherein, [0203] P1 comprises a polypeptide having protease activity; and [0204] variant Fc is any variant IgG Fc provided herein.

[0205] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

P1---variant Fc,

wherein, [0206] P1 comprises a polypeptide having protease activity; [0207] variant Fc is any variant IgG Fc provided herein; and
optionally wherein the protease is a glycosylation-resistant protease.

[0208] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

variant Fc---P1,

wherein, [0209] P1 comprises a polypeptide having protease activity; [0210] variant Fc is any variant IgG Fc provided herein; and
optionally wherein the protease is a glycosylation-resistant protease.

[0211] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

N1---P1---variant Fc,

wherein, [0212] P1 comprises a polypeptide having protease activity; [0213] N1 comprises a nanobody; and [0214] variant Fc is any variant IgG Fc provided herein.

[0215] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

variant Fc---P1---N1,

wherein, [0216] P1 comprises a polypeptide having protease activity; [0217] N1 comprises a nanobody; and [0218] variant Fc is any variant IgG Fc provided herein.

[0219] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

N1---variant Fc---P1,

wherein, [0220] P1 comprises a polypeptide having protease activity; [0221] N1 comprises a nanobody; and [0222] variant Fc is any variant IgG Fc provided herein.

[0223] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

P1---variant Fc---N1,

wherein, [0224] P1 comprises a polypeptide having protease activity; [0225] N1 comprises a nanobody; and [0226] variant Fc is any variant IgG Fc provided herein.

[0227] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

P1---N1,

wherein, [0228] P1 comprises a polypeptide having protease activity; and [0229] N1 comprises a nanobody.

[0230] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

N1---P1,

wherein, [0231] P1 comprises a polypeptide having protease activity; and [0232] N1 comprises a nanobody.

[0233] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

N1---P1---variant Fc,

wherein, [0234] P1 comprises a polypeptide having protease activity; [0235] N1 comprises a nanobody; and [0236] variant Fc is any variant IgG Fc provided herein; and
optionally wherein the protease is a glycosylation-resistant protease.

[0237] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

variant Fc---P1---N1,

wherein, [0238] P1 comprises a polypeptide having protease activity; [0239] N1 comprises a nanobody; and [0240] variant Fc is any variant IgG Fc provided herein; and
optionally wherein the protease is a glycosylation-resistant protease.

[0241] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

N1---variant Fc---P1,

wherein, [0242] P1 comprises a polypeptide having protease activity; [0243] N1 comprises a nanobody; and [0244] variant Fc is any variant IgG Fc provided herein; and
optionally wherein the protease is a glycosylation-resistant protease.

[0245] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

P1---variant Fc---N1,

wherein, [0246] P1 comprises a polypeptide having protease activity; [0247] N1 comprises a nanobody; and [0248] variant Fc is any variant IgG Fc provided herein; and
optionally wherein the protease is a glycosylation-resistant protease.

[0249] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

P1---N1,

wherein, [0250] P1 comprises a polypeptide having protease activity; and [0251] N1 comprises a nanobody; and
optionally wherein the protease is a glycosylation-resistant protease.

[0252] In some embodiments, a polypeptide has the formula from N-terminus to C-terminus:

N1---P1,

wherein, [0253] P1 comprises a polypeptide having protease activity; and [0254] N1 comprises a nanobody; and
optionally wherein the protease is a glycosylation-resistant protease.

[0255] In some embodiments, P1, and variant Fc are covalently or non-covalently conjugated to each other, as according to the above formulas. In some embodiments, P1, N1, and variant Fc are covalently or non-covalently conjugated to each other, as according to the above formulas.

[0256] In some embodiments, P1 comprises a polypeptide having protease activity. In some embodiments, N1 comprises a nanobody. In some embodiments, P1 comprises a polypeptide having protease activity, and N1 comprises a nanobody.

[0257] In some embodiments, P1 comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any sequence provided in Table 4, Table 5, Table 7, or Table 8. In some embodiments, P1 comprises a polypeptide having protease activity comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333.

[0258] In some embodiments, P1 comprises a polypeptide having protease activity comprising any sequence provided in Table 4, Table 5, Table 7, or Table 8. In some embodiments, P1 comprises a polypeptide having protease activity comprising an amino acid sequence of SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333.

[0259] In some embodiments, P1 comprises an IdeS, IdeSsuis, IdeE, IdeZ, IdeZ2, IdeE2, Ide85, or IdeC protease. In some embodiments, P1 comprises an IdeS, IdeSsuis, IdeE, IdeZ, IdeZ2, IdeE2, Ide85, or IdeC protease variant. In some embodiments, P1 comprises an IdeS, IdeSsuis, IdeE, IdeZ, IdeZ2, IdeE2, Ide85, or IdeC protease variant comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333.

[0260] In some embodiments, P1 comprises an IdeS, IdeSsuis, IdeE, IdeZ, IdeZ2, IdeE2, Ide85, or IdeC protease variant comprising an amino acid sequence of SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, 55-1019, 1290-1310, or 1333.

[0261] In some embodiments, the variant Fc comprises a variant Fc polypeptide. In some embodiments, the variant Fc polypeptide is such as those provided herein. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 47, 48, or 49. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 23.

[0262] In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 47, 48, or 49. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 19. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 20. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 21. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 22. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 24. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 25. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 42. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 43. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 44. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 45. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 46. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 47. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 48. In some embodiments, the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 49.

[0263] In some embodiments, N1 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 30, 32, or 33. In some embodiments, N1 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 30. In some embodiments, N1 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 32. In some embodiments, N1 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 33.

[0264] In some embodiments, N1 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 30, 32, or 33. In some embodiments, N1 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 30. In some embodiments, N1 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 32. In some embodiments, N1 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 33.

[0265] In some embodiments, R4 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 30, 32, or 33. In some embodiments, R4 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 30. In some embodiments, R4 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 32. In some embodiments, R4 comprises a nanobody comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to SEQ ID NO: 33.

[0266] In some embodiments, R4 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 30, 32, or 33. In some embodiments, R4 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 30. In some embodiments, R4 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 32. In some embodiments, R4 comprises a nanobody comprising an amino acid sequence of SEQ ID NO: 33.

[0267] In some embodiments, a polypeptide having the formula from N-terminus to C-terminus:

N1---P1---variant Fc---R2---R4,

further comprises a histidine tag (His-tag), wherein the His-tag is covalently or non-covalently conjugated to the C-terminus of the polypeptide. In some embodiments, the His-tag is such as those provided herein. In some embodiments, the His-tag comprises the sequence of HHHHHH (SEQ ID NO: 34), or HHHHHHHH (SEQ ID NO: 27).

[0268] In some embodiments, a molecule comprises: a) a dimer Fc molecule comprising: a first Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1(WT), provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and a second Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1(WT), provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1, wherein the first Fc polypeptide and the second Fc polypeptide associate with each other to form the dimer Fc molecule; and b) a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide.

[0269] In some embodiments, the Fc dimer molecule is a homodimer. In some embodiments, the Fc dimer molecule is a heterodimer. In some embodiments, the first Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.

[0270] In some embodiments, the second Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.

In some embodiments, the first Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and the second Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.

[0271] In some embodiments, a molecule comprises: a) a dimer Fc molecule comprising: a first Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and a second Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1, wherein the first Fc polypeptide and the second Fc polypeptide associate with each other to form the dimer Fc molecule; and b) a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, 1295, 1301, 1303, or 1310, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide.

[0272] In some embodiments, a molecule comprises a dimer Fc molecule comprising a first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and a second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, wherein the first Fc polypeptide and the second Fc polypeptide associate with each other to form the dimer Fc molecule; and a polypeptide having an amino acid sequence of any one, or any combination of SEQ ID NOs: 1290, 1295, 1301, 1303, and 1310, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide.

[0273] In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide.

[0274] In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide. In some embodiments, the molecule comprises the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide.

[0275] In some embodiments, a polypeptide comprises an amino acid sequence, and N-terminus to C-terminus orientation, as provided in Table 7, Table 8, Table 9, Table 10, Table 11, Table 12, and Table 13. In some embodiments, the polypeptide comprises a protease moiety, wherein the protease moiety is a polypeptide having protease activity, such as those provided herein. In some embodiments, the polypeptide comprises an Fc moiety, wherein the Fc moiety is a Fc variant such as those provided herein.

TABLE-US-00012 TABLE7 N-terminusProtease C-terminusFc ID Moiety Moiety FulllengthSequence VRT-1 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKDQIKRYLEEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKNHQLDSKLFEYFKEKAF IKRYLEEHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKNHQLDSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEI DPRGGIFDAVFTRGDQSKLLTS EKTISKAKGQPREPQV KEDNIGAQVLGLFTLSTGQDSWNQTNDKTHTCPPCPAP RHDFKEKNLKEISDLIKKELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGLSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSNGNLKAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIKEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV SWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 753) PG(SEQIDNO: 1023) 23) VRT-2 VTSVWTKGVTPPAKFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEKIEAYLKKHPD LLCGAATAGNMLHWWFDQNKEK ISRTPEVTCVVVDVSH KQKIMFGDQELLDVRKVINTKGDQTNSELFNYFRDKAF IEAYLKKHPDKQKIMFGDQELL EDPEVKFNWYVDGVEV PGLSARRIGVMPDLVLDMFINGYYLNVYKTQTTDVNRT DVRKVINTKGDQTNSELFNYFR HNAKTKPREEQQNSTY YQEKDRRGGIFDAVFTRGDQSKLLTSRHDFKEKNLKEI DKAFPGLSARRIGVMPDLVLDM RVVSVLTVLHQDWLNG SDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVYKTQTTDVNRTYQ KEYKCKVSNKALKAPI NGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAK EKDRRGGIFDAVFTRGDQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDSWNQTNDKTHTCPPCP TSRHDFKEKNLKEISDLIKKEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSNGNLKAIYVTDSDS WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDSWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 754) PG(SEQIDNO: 1024) 23) VRT-3 QITSVWTKGVTPLTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYD EDVIHAPYLAHQGWYDITKAFD APSVFLFPPKPKDTLM ITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLSKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKG NYFRDKAFPNLSARQLGVMPDL RVVSVLTVLHQDWLNG LNDISTIIKQELTEGRALALSHTYANVSISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVA RPYQDKDKRGGIFDAVFTRGDQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKGLNDISTII YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGRALALSHTYANVSIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDANASIGMKKYFVGINAHGH VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:755) PG(SEQIDNO: NO:1025) 23) VRT-4 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDV KMQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDSD KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIEL INKDFNRDSDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDGQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNGPV YWLDINRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKE IIELPDGQLKLSDFLNTYESDH RVVSVLTVLHQDWLNG VFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNGPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDENRLRLTAYEETHNTGGQIR DPTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKYAWADYFDKTEQTGTDQAEQDKTHTCPPC NNHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEN DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKYAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:756) 23) NO:1026) VRT-5 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKT HAPYKANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKDQIEAYLKEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKDDQTNSKLFEYFKEKAF IEAYLKEHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVLDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKDDQTNSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVLDM RVVSVLTVLHQDWLNG LIKQELTEGKALALSHTYANVRINHVINLWGADFDSNG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEI DPRGGIFDAVFTRGDQSKLLTS EKTISKAKGQPREPQV EDDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALALSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSNGNLEAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEDDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 757) PG(SEQIDNO: 1027) 23) VRT-6 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKDQIERYLKEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKDSQTDSKLFEYFKEKAF IERYLKEHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVLDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKDSQTDSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTSRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVLDM RVVSVLTVLHQDWLNG LIKQELTEGKALGLSHTYANVRINHVINLWGADFDSEG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAKEI DPRGGIFDAVFTRGDQSKLLTS EKTISKAKGQPREPQV KEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGLSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSEGNLKAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIKEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 758) PG(SEQIDNO: 1028) 23) VRT-7 VTSVWTKGVTPPTNFTYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DVKEAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEI DPRGGIFDAVFTRGDQSKLLTN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 759) PG(SEQIDNO: 1029) 23) VRT-8 VTSVWTKGVTPPADFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEY ISRTPEVTCVVVDVSH KQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAF IEAYLKKHPEKQKIMFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVMPDLVLDMFINGYYLNVTKTQTTDVNRT DVRKAINTKGSQKNSELFNYFR HNAKTKPREEQQNSTY YQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEI DKAFPNLSARRLGVMPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVTKTQTTDVNRTYQ KEYKCKVSNKALKAPI DGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAK EKDKRGGIFDAVFTRGDQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TSRHDFKEKGLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSDGNLKAIYVTDSDS WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 760) PG(SEQIDNO: 1030) 23) VRT-9 ITSVWTKGVTPPAKFTQGEDVF DKTHTCPPCPAPEAAG ITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEEIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEE ISRTPEVTCVVVDVSH KQKIMFGDQELLDVRKVINTKDSQTNSALFNYFKDKAF IEAYLKKHPEKQKIMFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVMPDLVLDMFINGYYLNVYKTQTTDVNRT DVRKVINTKDSQTNSALFNYFK HNAKTKPREEQQNSTY YQTKDRRGGIFDAVFTRGDQSKLLTERHDFKEKTLKEI DKAFPNLSARRLGVMPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVYKTQTTDVNRTYQ KEYKCKVSNKALKAPI NGNLEAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAK TKDRRGGIFDAVFTRGDQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TERHDFKEKTLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSNGNLEAIYVTDSDS WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 761) PG(SEQIDNO: 1031) 23) VRT-10 TITSVWTKGVTPPTPEDFRYNN DKTHTCPPCPAPEAAG TITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYD EDVLHAPYVANQGWYDITKTFD APSVFLFPPKPKDTLM ITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIERYLK GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFR NKEEIERYLKKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPNLSARQLGVMPDLVLDMFINGYYLNLGKTQSTD QELFDVKAAIDTKDSQTNSKLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKG NYFRDKAFPNLSARQLGVMPDL RVVSVLTVLHQDWLNG LNEISDLIKQELTEGKALALSHTYANVRINHVINLWGA VLDMFINGYYLNLGKTQSTDVN KEYKCKVSNKALKAPI DFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVA RPYQDKDKRGGIFDAVFTRGDQ EKTISKAKGQPREPQV ISAKKIEGDNIGAQVLGLFTLSTGQDIWQKLSDKTHTC TTLLTARHDLKNKGLNEISDLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIN LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFDAEGNLIAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDANASIGMKKYFVGVNANGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGDNIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSTGQDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:762) PG(SEQIDNO: NO:1032) 23) VRT-11 QITSVWTKGVTPPTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPPTPEQFRYNNEDVIHAPYLANQGWYD EDVIHAPYLANQGWYDITKTFN APSVFLFPPKPKDTLM ITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLSKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKT NYFRDKAFPNLSARQLGVMPDL RVVSVLTVLHQDWLNG LNDISTLIKQELTEGKALALSHTYANVSISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGKVA RPYQDKDKRGGIFDAVFTRGDQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKTLNDISTLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVSIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDANASIGMKKYFVGVNAHGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:763) PG(SEQIDNO: NO:1033) 23) VRT-12 QITSVWTKGVTPLTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYD EDVIHAPYLANQGWYDITKTFN APSVFLFPPKPKDTLM ITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLK GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLKKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKG NYFRDKAFPNLSARQLGVMPDL RVVSVLTVLHQDWLNG LNEISTLIKQELTEGKALALSHTYANVSISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNAHGKVA RPYQDKDKRGGIFDAVFTRGDQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKGLNEISTLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVSIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDSNASIGMKKYFVGVNAHGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:764) PG(SEQIDNO: NO:1034) 23) VRT-13 QITSVWTKGVTPPTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPPTPEQFRYNNEDVFHAPYTAHQGWYD EDVFHAPYTAHQGWYDITKTFD APSVFLFPPKPKDTLM ITKTFDGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYFR NKTEIEAYLSKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPNLSARQLGVMPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSALF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGDQTTLLTARHDLKNKT NYFRDKAFPNLSARQLGVMPDL RVVSVLTVLHQDWLNG LNDISTIIKQELTEGRALALSHTYANVSISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNASGKVA RPYQDKDKRGGIFDAVFTRGDQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKTLNDISTII YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGRALALSHTYANVSIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDSNASIGMKKYFVGVNASGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:765) PG(SEQIDNO: NO:1035) 23) VRT-14 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDV KKQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDSD KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIEL INKDFNRDSDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDGQLKLSDFLNTYESDDGYRDKSKLFDFISNNFNGPV YWLDRNRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKE IIELPDGQLKLSDFLNTYESDD RVVSVLTVLHQDWLNG VFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNGPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDEGRLRLTAYEETHNTGGQIR DPTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKQAWADYFDKTEQTGTDQAEQDKTHTCPPC NNHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEG DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKQAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:766) 23) NO:1036) VRT-15 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDV KKQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDSD KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIEL INKDFNRDSDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDGQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNGPV YWLDINRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDPTKNTSKINFFKE IIELPDGQLKLSDFLNTYESDH RVVSVLTVLHQDWLNG VFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNGPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDEGRLRLTAYEETHNTGGQIR DPTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKQAWADYFDKTEQTGTDQAEQDKTHTCPPC NNHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEG DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKQAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:767) 23) NO:1037) VRT-16 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKDQIKRYLEEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFNGEQLFDVKEAIDTKNHQLDSKLFEYFKEKAF IKRYLEEHPEKQKINFNGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKNHQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKNLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTS EKTISKAKGQPREPQV KEDNIGAQVLGLFTLSTGQDSWNQTNDKTHTCPPCPAP RHDFKEKNLKEISDLIKKELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGLSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSNGNLKAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIKEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV SWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 768) PG(SEQIDNO: 1038) 23) VRT-17 VTSVWTKGVTPPAKFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEKIEAYLKKHPD LLCGAATAGNMLHWWFDQNKEK ISRTPEVTCVVVDVSH KQKIIFGDQELLDVRKVINTKGDQTNSELFNYFRDKAF IEAYLKKHPDKQKIIFGDQELL EDPEVKFNWYVDGVEV PGLSARRIGVFPDLVLDMFINGYYLNVYKTQTTDVNRT DVRKVINTKGDQTNSELFNYFR HNAKTKPREEQQNSTY YQEKDRRGGIFDAVFTRGVQSKLLTSRHDFKEKNLKEI DKAFPGLSARRIGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVYKTQTTDVNRTYQ KEYKCKVSNKALKAPI NGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAK EKDRRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDSWNQTNDKTHTCPPCP TSRHDFKEKNLKEISDLIKKEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSNGNLKAIYVTDSDT WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDSWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 769) PG(SEQIDNO: 1039) 23) VRT-18 QITSVWTKGVTPLTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPLTPEQFRYNNEDVIHAPYLAHQGWYD EDVIHAPYLAHQGWYDITKAFD APSVFLFPPKPKDTLM ITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLSKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKG NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNDISTIIKQELTEGRALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDANASIGMKKYFVGINAHGHVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKGLNDISTII YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGRALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDANASIGMKKYFVGINAHGH VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:770) PG(SEQIDNO: NO:1040) 23) VRT-19 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDV KMQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDND KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIEL INKDFNRDNDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDGQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNGPV YWLDINRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKE IIELPDGQLKLSDFLNTYESDH RVVSVLTVLHQDWLNG VFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNGPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDENRLRLTAYEETHNTGGQIR DSTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKYAWADYFDKTEQTGTDQAEQDKTHTCPPC NNHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEN DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKYAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:771) 23) NO:1041) VRT-20 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKDQIKRYLEEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFKGEQLFDVKEAIDTKNHQLDSKLFEYFKEKAF IKRYLEEHPEKQKINFKGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKNHQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKNLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKKELTEGKALGLSHTYANVRINHVINLWGADFDSNG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLKAIYVTDSDTEASIGMKKYFVGVNKAGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTS EKTISKAKGQPREPQV KEDNIGAQVLGLFTLSTGQDSWNQTNDKTHTCPPCPAP RHDFKEKNLKEISDLIKKELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGLSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSNGNLKAIYVTDSDTEA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNKAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIKEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV SWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 772) PG(SEQIDNO: 1042) 23) VRT-21 VTSVWTKGVTPPAKFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKEKIEAYLKKHPD LLCGAATAGNMLHWWFDQNKEK ISRTPEVTCVVVDVSH KQKIIFGDQELLDVRKVINTKGDQTNSELFNYFRDKAF IEAYLKKHPDKQKIIFGDQELL EDPEVKFNWYVDGVEV PGLSARRIGVFPDLVLDMFINGYYLNVYKTQTTDVNRT DVRKVINTKGDQTNSELFNYFR HNAKTKPREEQQNSTY YQEKDRRGGIFDAVFTRGVQSKLLTSRHDFKEKNLKEI DKAFPGLSARRIGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKKELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVYKTQTTDVNRTYQ KEYKCKVSNKALKAPI NGNLKAIYVTDSDTRASIGMKKYFVGVNAAGKVAISAK EKDRRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDSWNQTNDKTHTCPPCP TSRHDFKEKNLKEISDLIKKEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSNGNLKAIYVTDSDT WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR RASIGMKKYFVGVNAAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDSWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 773) PG(SEQIDNO: 1043) 23) VRT-22 QITSVWTKGVTPLTPEQFRYYN DKTHTCPPCPAPEAAG QITSVWTKGVTPLTPEQFRYYNEDVIHAPYLAHQGWYD EDVIHAPYLAHQGWYDITKAFD APSVFLFPPKPKDTLM ITKAFDGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFKNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLSKHPEKQKIIFKN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKG NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNDISTIIKQELTEGRALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDTRASIGMKKYFVGINAHGHVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKGLNDISTII YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGRALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDTRASIGMKKYFVGINAHGH VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:774) PG(SEQIDNO: NO:1044) 23) VRT-23 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKMQNVVYTKWLDGVDV KMQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDND KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIEL INKDFNRDNDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDEQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNKPV YWLDINRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKE IIELPDEQLKLSDFLNTYESDH RVVSVLTVLHQDWLNG VFNEKILTNIHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNKPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDENRLRLTAYEETHNTGGQIR DSTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKYAWADYFDKTEQTGTDQAEQDKTHTCPPC NIHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEN DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKYAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:775) 23) NO:1045) VRT-24 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKT HAPYKANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKDQIEAYLKEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFNGEQLFDVKEAIDTKDDQTNSKLFEYFKEKAF IEAYLKEHPEKQKINFNGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVLDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKDDQTNSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVLDM RVVSVLTVLHQDWLNG LIKQELTEGKALALSHTYANVRINHVINLWGADFDSNG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTS EKTISKAKGQPREPQV EDDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALALSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSNGNLEAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEDDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 776) PG(SEQIDNO: 1046) 23) VRT-25 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKDQIERYLKEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFNGEQLFDVKEAIDTKDSQTDSKLFEYFKEKAF IERYLKEHPEKQKINFNGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVLDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKDSQTDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVLDM RVVSVLTVLHQDWLNG LIKQELTEGKALGLSHTYANVRINHVINLWGADFDSEG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTS EKTISKAKGQPREPQV KEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGLSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSEGNLKAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIKEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 777) PG(SEQIDNO: 1047) 23) VRT-26 VTSVWTKGVTPPTNFTYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKINFNGEQLFDVKEAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKINFNGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DVKEAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 778) PG(SEQIDNO: 1048) 23) VRT-27 VTSVWTKGVTPPADFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEYIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEY ISRTPEVTCVVVDVSH KQKIIFGDQELLDVRKAINTKGSQKNSELFNYFRDKAF IEAYLKKHPEKQKIIFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVFPDLVLDMFINGYYLNVTKTQTTDVNRT DVRKAINTKGSQKNSELFNYFR HNAKTKPREEQQNSTY YQEKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKGLKEI DKAFPNLSARRLGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVTKTQTTDVNRTYQ KEYKCKVSNKALKAPI DGNLKAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAK EKDKRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TSRHDFKEKGLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSDGNLKAIYVTDSDT WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 779) PG(SEQIDNO: 1049) 23) VRT-28 ITSVWTKGVTPPAKFTQGEDVF DKTHTCPPCPAPEAAG ITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEEIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEE ISRTPEVTCVVVDVSH KQKIIFGDQELLDVRKVINTKDSQTNSALFNYFKDKAF IEAYLKKHPEKQKIIFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVFPDLVLDMFINGYYLNVYKTQTTDVNRT DVRKVINTKDSQTNSALFNYFK HNAKTKPREEQQNSTY YQTKDRRGGIFDAVFTRGVQSKLLTERHDFKEKTLKEI DKAFPNLSARRLGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVYKTQTTDVNRTYQ KEYKCKVSNKALKAPI NGNLEAIYVTDSDTNASIGMKKYFVGVNSAGKVAISAK TKDRRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TERHDFKEKTLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSNGNLEAIYVTDSDT WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 780) PG(SEQIDNO: 1050) 23) VRT-29 TITSVWTKGVTPPTPEDFRYNN DKTHTCPPCPAPEAAG TITSVWTKGVTPPTPEDFRYNNEDVLHAPYVANQGWYD EDVLHAPYVANQGWYDITKTFD APSVFLFPPKPKDTLM ITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIERYLK GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDVKAAIDTKDSQTNSKLFNYFR NKEEIERYLKKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNLGKTQSTD QELFDVKAAIDTKDSQTNSKLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKG NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNEISDLIKQELTEGKALALSHTYANVRINHVINLWGA VLDMFINGYYLNLGKTQSTDVN KEYKCKVSNKALKAPI DFDAEGNLIAIYVTDSDANASIGMKKYFVGVNANGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGDNIGAQVLGLFTLSTGQDIWQKLSDKTHTC TTLLTARHDLKNKGLNEISDLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIN LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFDAEGNLIAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDANASIGMKKYFVGVNANGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGDNIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSTGQDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:781) PG(SEQIDNO: NO:1051) 23) VRT-30 QITSVWTKGVTPPTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPPTPEQFRYNNEDVIHAPYLANQGWYD EDVIHAPYLANQGWYDITKTFN APSVFLFPPKPKDTLM ITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLSKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKT NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNDISTLIKQELTEGKALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDANASIGMKKYFVGVNAHGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKTLNDISTLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDANASIGMKKYFVGVNAHGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:782) PG(SEQIDNO: NO:1052) 23) VRT-31 QITSVWTKGVTPLTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPLTPEQFRYNNEDVIHAPYLANQGWYD EDVIHAPYLANQGWYDITKTFN APSVFLFPPKPKDTLM ITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLK GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLKKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKG NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNEISTLIKQELTEGKALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNAHGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKGLNEISTLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDSNASIGMKKYFVGVNAHGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:783) PG(SEQIDNO: NO:1053) 23) VRT-32 QITSVWTKGVTPPTPEQFRYNN DKTHTCPPCPAPEAAG QITSVWTKGVTPPTPEQFRYNNEDVFHAPYTAHQGWYD EDVFHAPYTAHQGWYDITKTFD APSVFLFPPKPKDTLM ITKTFDGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFNNQELFDLKAAIDTKDSQTNSALFNYFR NKTEIEAYLSKHPEKQKIIFNN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSALF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKT NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNDISTIIKQELTEGRALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDSNASIGMKKYFVGVNASGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKILNDISTII YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGRALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDSNASIGMKKYFVGVNASGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:784) PG(SEQIDNO: NO:1054) 23) VRT-33 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDV KKQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDND KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIEL INKDFNRDNDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDGQLKLSDFLNTYESDDGYRDKSKLFDFISNNFNGPV YWLDRNRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKE IIELPDGQLKLSDFLNTYESDD RVVSVLTVLHQDWLNG VFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNGPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDEGRLRLTAYEETHNTGGQIR DSTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKQAWADYFDKTEQTGTDQAEQDKTHTCPPC NNHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEG DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKQAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:785) 23) NO:1055) VRT-34 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDV KKQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDND KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIEL INKDFNRDNDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDGQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNGPV YWLDINRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKE IIELPDGQLKLSDFLNTYESDH RVVSVLTVLHQDWLNG VFNEKILTNNHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNGPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDEGRLRLTAYEETHNTGGQIR DSTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKQAWADYFDKTEQTGTDQAEQDKTHTCPPC NNHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEG DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKQAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:786) 23) NO:1056) VRT-35 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYKANQGWYDITKT HAPYKANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKDQIEAYLKEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFKGEQLFDVKEAIDTKDDQTNSKLFEYFKEKAF IEAYLKEHPEKQKINFKGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVLDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKDDQTNSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVLDM RVVSVLTVLHQDWLNG LIKQELTEGKALALSHTYANVRINHVINLWGADFDSNG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTEASIGMKKYFVGVNKAGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTS EKTISKAKGQPREPQV EDDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALALSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSNGNLEAIYVTDSDTEA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNKAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEDDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 787) PG(SEQIDNO: 1057) 23) VRT-36 VTSVWTKGVTPPANFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPANFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKDQIERYLKEHPE LLCGAATAGNMLHWWFDQNKDQ ISRTPEVTCVVVDVSH KQKINFKGEQLFDVKEAIDTKDSQTDSKLFEYFKEKAF IERYLKEHPEKQKINFKGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVLDMFINGYRLSLTNHGPTPVKEG DVKEAIDTKDSQTDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVLDM RVVSVLTVLHQDWLNG LIKQELTEGKALGLSHTYANVRINHVINLWGADFDSEG FINGYRLSLTNHGPTPVKEGSK KEYKCKVSNKALKAPI NLKAIYVTDSDTEASIGMKKYFVGVNKAGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTS EKTISKAKGQPREPQV KEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGLSHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDSEGNLKAIYVTDSDTEA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNKAGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIKEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 788) PG(SEQIDNO: 1058) 23) VRT-37 VTSVWTKGVTPPTNFTYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKINFKGEQLFDVKEAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKINFKGEQLF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DVKEAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTEASIGMKKYFVGVNKNGKVAISAKEI DKRGGIFDAVFTRGVQSKLLIN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDTEA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNKNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 789) PG(SEQIDNO: 1059) 23) VRT-38 VTSVWTKGVTPPADFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKEYIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEY ISRTPEVTCVVVDVSH KQKIIFGDQELLDVRKAINTKGSQKNSELFNYFRDKAF IEAYLKKHPEKQKIIFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVFPDLVLDMFINGYYLNVTKTQTTDVNRT DVRKAINTKGSQKNSELFNYFR HNAKTKPREEQQNSTY YQEKDKRGGIFDAVFTRGVQSKLLTSRHDFKEKGLKEI DKAFPNLSARRLGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVTKTQTTDVNRTYQ KEYKCKVSNKALKAPI DGNLKAIYVTDSDTRASIGMKKYFVGVNAAGKVAISAK EKDKRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TSRHDFKEKGLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSDGNLKAIYVTDSDT WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR RASIGMKKYFVGVNAAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 790) PG(SEQIDNO: 1060) 23) VRT-39 ITSVWTKGVTPPAKFTQGEDVF DKTHTCPPCPAPEAAG ITSVWTKGVTPPAKFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNRKDN APSVFLFPPKPKDTLM FNRKDNLLCGAATAGNMLHWWFDQNKEEIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEE ISRTPEVTCVVVDVSH KQKIIFGDQELLDVRKVINTKDSQTNSALFNYFKDKAF IEAYLKKHPEKQKIIFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVFPDLVLDMFINGYYLNVYKTQTTDVNRT DVRKVINTKDSQTNSALFNYFK HNAKTKPREEQQNSTY YQTKDRRGGIFDAVFTRGVQSKLLTERHDFKEKTLKEI DKAFPNLSARRLGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVYKTQTTDVNRTYQ KEYKCKVSNKALKAPI NGNLEAIYVTDSDTRASIGMKKYFVGVNAAGKVAISAK TKDRRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TERHDFKEKTLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSNGNLEAIYVTDSDT WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR RASIGMKKYFVGVNAAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 791) PG(SEQIDNO: 1061) 23) VRT-40 TITSVWTKGVTPPTPEDFRYYN DKTHTCPPCPAPEAAG TITSVWTKGVTPPTPEDFRYYNEDVLHAPYVANQGWYD EDVLHAPYVANQGWYDITKTFD APSVFLFPPKPKDTLM ITKTFDGKDNLLCGAATAGNMLHWWFDQNKEEIERYLK GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFKNQELFDVKAAIDTKDSQTNSKLFNYFR NKEEIERYLKKHPEKQKIIFKN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNLGKTQSTD QELFDVKAAIDTKDSQTNSKLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKG NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNEISDLIKQELTEGKALALSHTYANVRINHVINLWGA VLDMFINGYYLNLGKTQSTDVN KEYKCKVSNKALKAPI DFDAEGNLIAIYVTDSDTRASIGMKKYFVGVNANGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGDNIGAQVLGLFTLSTGQDIWQKLSDKTHTC TTLLTARHDLKNKGLNEISDLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIN LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFDAEGNLIAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDTRASIGMKKYFVGVNANGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGDNIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSTGQDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:792) PG(SEQIDNO: NO:1062) 23) VRT-41 QITSVWTKGVTPPTPEQFRYYN DKTHTCPPCPAPEAAG QITSVWTKGVTPPTPEQFRYYNEDVIHAPYLANQGWYD EDVIHAPYLANQGWYDITKTFN APSVFLFPPKPKDTLM ITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFKNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLSKHPEKQKIIFKN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKT NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNDISTLIKQELTEGKALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDTRASIGMKKYFVGVNAHGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKTLNDISTLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDTRASIGMKKYFVGVNAHGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:793) PG(SEQIDNO: NO:1063) 23) VRT-42 QITSVWTKGVTPLTPEQFRYYN DKTHTCPPCPAPEAAG QITSVWTKGVTPLTPEQFRYYNEDVIHAPYLANQGWYD EDVIHAPYLANQGWYDITKTFN APSVFLFPPKPKDTLM ITKTFNGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLK GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFKNQELFDLKAAIDTKDSQTNSQLFNYFR NKTEIEAYLKKHPEKQKIIFKN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSQLF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKG NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNEISTLIKQELTEGKALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDSRASIGMKKYFVGVNAHGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKGLNEISTLI YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGKALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDSRASIGMKKYFVGVNAHGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:794) PG(SEQIDNO: NO:1064) 23) VRT-43 QITSVWTKGVTPPTPEQFRYYN DKTHTCPPCPAPEAAG QITSVWTKGVTPPTPEQFRYYNEDVFHAPYTAHQGWYD EDVFHAPYTAHQGWYDITKTFD APSVFLFPPKPKDTLM ITKTFDGKDNLLCGAATAGNMLHWWFDQNKTEIEAYLS GKDNLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKIIFKNQELFDLKAAIDTKDSQTNSALFNYFR NKTEIEAYLSKHPEKQKIIFKN EDPEVKFNWYVDGVEV DKAFPGLSARQLGVFPDLVLDMFINGYYLNVFKTQSTD QELFDLKAAIDTKDSQTNSALF HNAKTKPREEQQNSTY VNRPYQDKDKRGGIFDAVFTRGVQTTLLTARHDLKNKT NYFRDKAFPGLSARQLGVFPDL RVVSVLTVLHQDWLNG LNDISTIIKQELTEGRALALSHTYANVRISHVINLWGA VLDMFINGYYLNVFKTQSTDVN KEYKCKVSNKALKAPI DFNAEGNLEAIYVTDSDSRASIGMKKYFVGVNASGKVA RPYQDKDKRGGIFDAVFTRGVQ EKTISKAKGQPREPQV ISAKKIEGENIGAQVLGLFTLSSGKDIWQKLSDKTHTC TTLLTARHDLKNKTLNDISTII YTLPPSRDELTKNQVS PPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVV KQELTEGRALALSHTYANVRIS LTCLVKGFYPSDIAVE DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRV HVINLWGADFNAEGNLEAIYVT WESNGQPENNYKTTPP VSVLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAK DSDSRASIGMKKYFVGVNASGK VLDSDGSFFLYSKLTV GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIA VAISAKKIEGENIGAQVLGLFT DKSRWQQGNVFSCSVM VEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSR LSSGKDIWQKLS(SEQID HEALHNHYTQKSLSLS WQQGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID NO:795) PG(SEQIDNO: NO:1065) 23) VRT-44 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDV KKQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDND KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDRNRDNVDRFLRQNPEKHGIIEL INKDFNRDNDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDEQLKLSDFLNTYESDDGYRDKSKLFDFISNNFNKPV YWLDRNRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKE IIELPDEQLKLSDFLNTYESDD RVVSVLTVLHQDWLNG VFNEKILTNIHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNKPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDEGRLRLTAYEETHNTGGQIR DSTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKQAWADYFDKTEQTGTDQAEQDKTHTCPPC NIHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEG DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKQAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:796) 23) NO:1066) VRT-45 SQTEDSESLQRLRDIEDFQAEK DKTHTCPPCPAPEAAG SQTEDSESLQRLRDIEDFQAEKKKQNVVYTKWLDGVDV KKQNVVYTKWLDGVDVKDHDFR APSVFLFPPKPKDTLM KDHDFRKIVDGNIAYYATPLLNGRGFYDINKDFNRDND KIVDGNIAYYATPLLNGRGFYD ISRTPEVTCVVVDVSH KCAAAVAANMFHYWLDINRDNVDRFLRQNPEKHGIIEL INKDFNRDNDKCAAAVAANMFH EDPEVKFNWYVDGVEV PDEQLKLSDFLNTYESDHGYRDKSKLFDFISNNFNKPV YWLDINRDNVDRFLRQNPEKHG HNAKTKPREEQQNSTY WTDKLLDNYINGYAYNYKYGRTIEDSTKNTSKINFFKE IIELPDEQLKLSDFLNTYESDH RVVSVLTVLHQDWLNG VFNEKILTNIHSIRNQNEFSVLLSEALYTGKAIGLSYG GYRDKSKLFDFISNNFNKPVWT KEYKCKVSNKALKAPI PAGLRHSLGHIISVWGADLDADGNVVAIYVTDSDDKKL DKLLDNYINGYAYNYKYGRTIE EKTISKAKGQPREPQV TIGDERVGLKRYKISTDDEGRLRLTAYEETHNTGGQIR DSTKNTSKINFFKEVFNEKILT YTLPPSRDELTKNQVS GLWTLDTGKQAWADYFDKTEQTGTDQAEQDKTHTCPPC NIHSIRNQNEFSVLLSEALYTG LTCLVKGFYPSDIAVE PAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVS KAIGLSYGPAGLRHSLGHIISV WESNGQPENNYKTTPP HEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSV WGADLDADGNVVAIYVTDSDDK VLDSDGSFFLYSKLTV LTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQP KLTIGDERVGLKRYKISTDDEG DKSRWQQGNVFSCSVM REPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEW RLRLTAYEETHNTGGQIRGLWT HEALHNHYTQKSLSLS ESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ LDTGKQAWADYFDKTEQTGTDQ PG(SEQIDNO: GNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID AEQ(SEQIDNO:797) 23) NO:1067) VRT-46 VTSVWTKGVTPPTDFIYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKT HAPYKAGQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DVKEAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTNRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEI DPRGGIFDAVFTRGDQSKLLIN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 798) PG(SEQIDNO: 1068) 23) VRT-47 VTSVWTKGVTPPTDFIYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKT HAPYKAGQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DVKEAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEI DPRGGIFDAVFTRGDQSKLLTN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDLKNKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 799) PG(SEQIDNO: 1069) 23) VRT-48 VTSVWTKGVTPPTDFRKIVDGN DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFRKIVDGNIAYYHAPYKAGQGWYD IAYYHAPYKAGQGWYDITKAFD APSVFLFPPKPKDTLM ITKAFDGGDDLLCGAATAGNMLHWWFDQNKEQIENYLK GGDDLLCGAATAGNMLHWWFDQ ISRTPEVTCVVVDVSH KHPEKQKINFNGEQMFDVKEAIDTKDSQTNSELFNYFK NKEQIENYLKKHPEKQKINFNG EDPEVKFNWYVDGVEV EKAFPYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTP EQMFDVKEAIDTKDSQTNSELF HNAKTKPREEQQNSTY VKRGSKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLK NYFKEKAFPYLSTKHLGVFPDH RVVSVLTVLHQDWLNG EISDLIKQELTEGKALGISHTYANVRINHVINLWGADF VIDMFINGYRLSLTNHGPTPVK KEYKCKVSNKALKAPI DAEGNLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAIS RGSKDPRGGIFDAVFTRGDQSK EKTISKAKGQPREPQV AKEIEEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPP LLTNRHDLKNKTLKEISDLIKQ YTLPPSRDELTKNQVS CPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDV ELTEGKALGISHTYANVRINHV LTCLVKGFYPSDIAVE SHEDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVS INLWGADFDAEGNLEAIYVTDS WESNGQPENNYKTTPP VLTVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQ DSNASIGMKKYFVGVNSNGKVA VLDSDGSFFLYSKLTV PREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE ISAKEIEEDNIGAQVLGLFTLS DKSRWQQGNVFSCSVM WESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQ TGQDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS QGNVFSCSVMHEALHNHYTQKSLSLSPG(SEQID 800) PG(SEQIDNO: NO:1070) 23) VRT-49 VTSVWTKGVTPPTNFTYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKINFNGEQMFDVKEAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKINFNGEQMF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DVKEAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDPRGGIFDAVFTRGDQSKLLTNRHDLKNKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDSNASIGMKKYFVGVNSNGKVAISAKEI DPRGGIFDAVFTRGDQSKLLTN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDLKNKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDSNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 801) PG(SEQIDNO: 1071) 23) VRT-50 VTSVWTKGVTPPTDFIYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKT HAPYKAGQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKIIFNNQELF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DLKAAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTNRHDFKEKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDFKEKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 802) PG(SEQIDNO: 1072) 23) VRT-51 VTSVWTKGVTPPTDFIYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKT HAPYKAGQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKIIFNNQELF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DLKAAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEI DKRGGIFDAVFTRGVQSKLLIN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDLKNKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 803) PG(SEQIDNO: 1073) 23) VRT-52 VTSVWTKGVTPPTDFIYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIYGEDVLHAPYKAGQGWYDITKA HAPYKAGQGWYDITKAFDGGDN APSVFLFPPKPKDTLM FDGGDNLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKIIFNNQELFDLKAAIDTKDSQTNSELFNYFKEKAF IENYLKKHPEKQKIIFNNQELF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DLKAAIDTKDSQTNSELFNYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEI DKRGGIFDAVFTRGVQSKLLTN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDLKNKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 804) PG(SEQIDNO: 1074) 23) VRT-53 VTSVWTKGVTPPTNFTYGEDVL DKTHTCPPCPAPEAAG VTSVWTKGVTPPTNFTYGEDVLHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEQIENYLKKHPE LLCGAATAGNMLHWWFDQNKEQ ISRTPEVTCVVVDVSH KQKIIFNNQELFDLKAAIDTKDSQLDSKLFEYFKEKAF IENYLKKHPEKQKIIFNNQELF EDPEVKFNWYVDGVEV PYLSTKHLGVFPDHVIDMFINGYRLSLTNHGPTPVKRG DLKAAIDTKDSQLDSKLFEYFK HNAKTKPREEQQNSTY SKDKRGGIFDAVFTRGVQSKLLTNRHDLKNKTLKEISD EKAFPYLSTKHLGVFPDHVIDM RVVSVLTVLHQDWLNG LIKQELTEGKALGISHTYANVRINHVINLWGADFDAEG FINGYRLSLTNHGPTPVKRGSK KEYKCKVSNKALKAPI NLEAIYVTDSDTNASIGMKKYFVGVNSNGKVAISAKEI DKRGGIFDAVFTRGVQSKLLIN EKTISKAKGQPREPQV EEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCPAP RHDLKNKTLKEISDLIKQELTE YTLPPSRDELTKNQVS EAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED GKALGISHTYANVRINHVINLW LTCLVKGFYPSDIAVE PEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVLTV GADFDAEGNLEAIYVTDSDTNA WESNGQPENNYKTTPP LHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPREP SIGMKKYFVGVNSNGKVAISAK VLDSDGSFFLYSKLTV QVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESN EIEEDNIGAQVLGLFTLSTGQD DKSRWQQGNVFSCSVM GQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNV IWNQTN(SEQIDNO: HEALHNHYTQKSLSLS FSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 805) PG(SEQIDNO: 1075) 23) VRT-54 VTSVWTKGVTPPTDFIKGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKT HAPYKAGQGWYDITKTFNGKDD APSVFLFPPKPKDTLM FNGKDDLLCGAATAGNMLHWWFDQNKEYIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEY ISRTPEVTCVVVDVSH KQKIMFGDQELLDVRKAINTKGSQKNSELFNYFRDKAF IEAYLKKHPEKQKIMFGDQELL EDPEVKFNWYVDGVEV PNLSARRLGVMPDLVLDMFINGYYLNVTKTQTTDVNRT DVRKAINTKGSQKNSELFNYFR HNAKTKPREEQQNSTY YQEKDKRGGIFDAVFTRGDQSKLLTSRHDFKEKGLKEI DKAFPNLSARRLGVMPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVTKTQTTDVNRTYQ KEYKCKVSNKALKAPI DGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAK EKDKRGGIFDAVFTRGDQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TSRHDFKEKGLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSDGNLKAIYVTDSDS WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 806) PG(SEQIDNO: 1076) 23) VRT-58 VTSVWTKGVTPPTDFIKGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPTDFIKGEDVFHAPYKAGQGWYDITKT HAPYKAGQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEYIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEY ISRTPEVTCVVVDVSH KQKIIFNNQELFDLKAAINTKGSQKNSELFNYFRDKAF IEAYLKKHPEKQKIIFNNQELF EDPEVKFNWYVDGVEV PNLSARRLGVFPDLVLDMFINGYYLNVTKTQTTDVNRT DLKAAINTKGSQKNSELFNYFR HNAKTKPREEQQNSTY YQEKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKGLKEI DKAFPNLSARRLGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVTKTQTTDVNRTYQ KEYKCKVSNKALKAPI DGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAK EKDKRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TSRHDLKNKGLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSDGNLKAIYVTDSDS WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 810) PG(SEQIDNO: 1080) 23) VRT-59 VTSVWTKGVTPPADFTQGEDVF DKTHTCPPCPAPEAAG VTSVWTKGVTPPADFTQGEDVFHAPYVANQGWYDITKT HAPYVANQGWYDITKTFNGKDN APSVFLFPPKPKDTLM FNGKDNLLCGAATAGNMLHWWFDQNKEYIEAYLKKHPE LLCGAATAGNMLHWWFDQNKEY ISRTPEVTCVVVDVSH KQKIIFNNQELFDLKAAINTKGSQKNSELFNYFRDKAF IEAYLKKHPEKQKIIFNNQELF EDPEVKFNWYVDGVEV PNLSARRLGVFPDLVLDMFINGYYLNVTKTQTTDVNRT DLKAAINTKGSQKNSELFNYFR HNAKTKPREEQQNSTY YQEKDKRGGIFDAVFTRGVQSKLLTSRHDLKNKGLKEI DKAFPNLSARRLGVFPDLVLDM RVVSVLTVLHQDWLNG SDLIKQELTEGKALGLSHTYANVRINHVINLWGADFDS FINGYYLNVTKTQTTDVNRTYQ KEYKCKVSNKALKAPI DGNLKAIYVTDSDSNASIGMKKYFVGVNSAGKVAISAK EKDKRGGIFDAVFTRGVQSKLL EKTISKAKGQPREPQV EIKEDNIGAQVLGLFTLSTGQDIWNQTNDKTHTCPPCP TSRHDLKNKGLKEISDLIKQEL YTLPPSRDELTKNQVS APEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH TEGKALGLSHTYANVRINHVIN LTCLVKGFYPSDIAVE EDPEVKFNWYVDGVEVHNAKTKPREEQQNSTYRVVSVL LWGADFDSDGNLKAIYVTDSDS WESNGQPENNYKTTPP TVLHQDWLNGKEYKCKVSNKALKAPIEKTISKAKGQPR NASIGMKKYFVGVNSAGKVAIS VLDSDGSFFLYSKLTV EPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWE AKEIKEDNIGAQVLGLFTLSTG DKSRWQQGNVFSCSVM SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQG QDIWNQTN(SEQIDNO: HEALHNHYTQKSLSLS NVFSCSVMHEALHNHYTQKSLSLSPG(SEQIDNO: 811) PG(SEQIDNO: 1081) 23)

TABLE-US-00013 TABLE8 N-terminusFc C-terminusProtease ID Moiety Linker Moiety FulllengthSequence VRT-60 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDSNASIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 812) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1082) VRT-61 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDSNPSIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 813) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1083) VRT-62 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFDYFKE SDIAVEWESNGQPE NGRINHVINLWGADFDSNG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDSNPSIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 814) GAQVLGLFTLSTGQDSWNQIN(SEQID 23) NO:1084) VRT-63 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIAVTDSDSNASIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIAVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 815) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1085) VRT-64 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFLE SDIAVEWESNGQPE NGRINHVINLWGADFDSNG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIAVTDSDSNASIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDSNGNLKAIAVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 816) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1086) VRT-65 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLIN NNYKTTPPVLDSDG NLKAIYVTDSDSNPSIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQIN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 817) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1087) VRT-66 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLIN NNYKTTPPVLDSDG NLKAIAVTDSDSNASIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIAVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIKEDNI PG(SEQIDNO: 818) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1088) VRT-67 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 819) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1089) VRT-68 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 820) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1090) VRT-69 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 821) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1091) VRT-70 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 822) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1092) VRT-71 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 823) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1093) VRT-72 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNKSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSDGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNKSIGMKKYFVGVNSDGKVAISAKEIEEDNI PG(SEQIDNO: 824) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1094) VRT-73 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNKSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYPVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNKSIGMKKYPVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 825) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1095) VRT-74 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVGINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVGINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 826) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1096) VRT-75 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVGINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVGINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 827) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1097) VRT-76 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 828) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1098) VRT-77 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TYGEDVLHAPYVANQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLIN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 829) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1099) VRT-78 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTENGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 830) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1100) VRT-79 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLEDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTNPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 831) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1101) VRT-80 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDINPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 832) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1102) VRT-81 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 833) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1103) VRT-82 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLEDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 834) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1104) VRT-83 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLEAIYVTDSDTNPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 835) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1105) VRT-84 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLEAIAVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 836) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1106) VRT-85 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 837) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1107) VRT-86 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 838) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1108) VRT-87 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 839) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1109) VRT-88 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 840) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1110) VRT-89 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 841) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1111) VRT-90 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 842) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1112) VRT-91 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS IYGEDVLHAPYKAGQGWYDITKLFNGKDDLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQMFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLEAIAVTDSDSNASIGMK HGPTPVKRGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: SNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 843) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1113) VRT-92 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 844) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1114) VRT-93 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTNPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 845) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1115) VRT-94 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLEDYFKE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDINPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 846) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1116) VRT-95 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 847) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1117) VRT-96 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NGRINHVINLWGADFDAEG KAFPNLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIAVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANGRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 848) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1118) VRT-97 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFDYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLEAIYVTDSDINPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNPSIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 849) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1119) VRT-98 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKLFNGKDNLLC QVYTLPPSRDELTK KLLTNRHDLKNKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLIN NNYKTTPPVLDSDG NLEAIAVTDSDTNASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI NRHDLKNKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIAVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TNASIGMKKYFVGVNSSGKVAISAKEIEEDNI PG(SEQIDNO: 850) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1120) VRT-99 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:851) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1121) VRT-100 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTENGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:852) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1122) VRT-101 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRLNHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRLNHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:853) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1123) VRT-102 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYFVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:854) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1124) VRT-103 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRLNHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRLNHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:855) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1125) VRT-104 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PGLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPGLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:856) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1126) VRT-105 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:857) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1127) VRT-106 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKE ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKEFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:858) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1128) VRT-107 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKE ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRIGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKEFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IMFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRIGVMPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:859) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1129) VRT-108 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:860) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1130) VRT-109 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:861) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1131) VRT-110 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRLNHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRLNHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:862) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1132) VRT-111 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:863) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1133) VRT-112 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRLNHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRLNHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:864) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1134) VRT-113 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:865) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1135) VRT-114 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:866) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1136) VRT-115 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKE ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYVANQGWYDITKEFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:867) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1137) VRT-116 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDANQGWYDITKE ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD TQGEDVFHAPYDANQGWYDITKEFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:868) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1138) VRT-117 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:869) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1139) VRT-118 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:870) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1140) VRT-119 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRLNHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRLNHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:871) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1141) VRT-120 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYDAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:872) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1142) VRT-121 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYKAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRLNHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRLNHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:873) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1143) VRT-122 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYDAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:874) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1144) VRT-123 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYDAGQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRISHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYFVGVNSSGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRISHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYFVGVNSSGKVAISAKEIKED PG(SEQIDNO: NO:875) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1145) VRT-124 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKAGQGWYDITKE ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYKAGQGWYDITKEFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:876) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1146) VRT-125 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIKGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYDAGQGWYDITKE ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIMFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVMPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGD IKGEDVFHAPYDAGQGWYDITKEFNGKDDLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IMFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVRIGHVINLWGADFDS KAFPNLSARRLGVMPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDSNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGDQSKL SFFLYSKLTVDKSR MKKYGVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRIGHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDSNASIGMKKYGVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:877) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1147) VRT-126 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG KNNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVGKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRKNNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFNNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:878) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1148) VRT-127 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVGKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFNNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NVGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSLGKDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:879) IEGENIGAQVLGLFTLSLGKDIWQKLS(SEQ 23) IDNO:1149) VRT-128 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVGKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFD SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NVGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSSGKDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:880) IEGENIGAQVLGLFTLSSGKDQWQKLS(SEQ 23) IDNO:1150) VRT-129 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVFKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFNNQELFDLKAAIDTKDSQTNSQLFD SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSSGKDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:881) IEGENIGAQVLGLFTLSSGKDQWQKLS(SEQ 23) IDNO:1151) VRT-130 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQEWFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFNNQEWFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:882) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1152) VRT-131 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVGKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:883) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1153) VRT-132 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVGKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFD SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGELEAIYVTDSDAN NVGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFNAEGELEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:884) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1154) VRT-133 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVGKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFD SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGELEAIYVTDSDAN NVGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFNAEGELEAI ALHNHYTQKSLSLS TLSSGKDQWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:885) IEGENIGAQVLGLFTLSSGKDQWQKLS(SEQ 23) IDNO:1155) VRT-134 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVFKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFNNQELFDLKAAIDTKDSQTNSQLFD SDIAVEWESNGQPE LSHTYANVSISHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGELEAIYVTDSDAN NVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVSISHVINLWGADFNAEGELEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGHVAISAKK PG(SEQIDNO: IDNO:886) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1156) VRT-135 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG KNNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRKNNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:887) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1157) VRT-136 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSLGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:888) IEGDNIGAQVLGLFTLSLGQDIWQKLS(SEQ 23) IDNO:1158) VRT-137 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG YNNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQEWFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRYNNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSLGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGVNANGKVAISAKK PG(SEQIDNO: IDNO:889) IEGDNIGAQVLGLFTLSLGQDIWQKLS(SEQ 23) IDNO:1159) VRT-138 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSLGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:890) IEGDNIGAQVLGLFTLSLGQDIWQKLS(SEQ 23) IDNO:1160) VRT-139 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:891) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1161) VRT-140 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:892) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1162) VRT-141 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:893) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1163) VRT-142 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQEWFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:894) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1164) VRT-143 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:895) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1165) VRT-144 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DEDAEGELIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:896) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1166) VRT-145 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:897) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1167) VRT-146 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:898) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1168) VRT-147 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG KNNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRKNNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:899) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1169) VRT-148 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSLGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:900) IEGDNIGAQVLGLFTLSLGQDIWQKLS(SEQ 23) IDNO:1170) VRT-149 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:901) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1171) VRT-150 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:902) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1172) VRT-151 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQEWFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:903) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1173) VRT-152 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:904) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1174) VRT-153 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:905) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1175) VRT-154 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:906) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1176) VRT-155 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR PSIGMKKYFVGRNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNANGKVAISAKK PG(SEQIDNO: IDNO:907) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1177) VRT-156 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG KNNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRKNNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:908) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1178) VRT-157 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSLGQDIWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:909) IEGDNIGAQVLGLFTLSLGQDIWQKLS(SEQ 23) IDNO:1179) VRT-158 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:910) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1180) VRT-159 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWING VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:911) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1181) VRT-160 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQEWFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQEWFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR ASIGMKKYAVGVNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNAHGKVAISAKK PG(SEQIDNO: IDNO:912) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1182) VRT-161 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:913) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1183) VRT-162 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGELEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:914) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1184) VRT-163 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGELEAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:915) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1185) VRT-164 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFNNQELFDVKAAIDTKDSQTNSKLFD SDIAVEWESNGQPE LSHTYANVSINHVINLWGA YFRDKAFPNLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELEAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGD SFFLYSKLTVDKSR PSIGMKKYFVGRNAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVSINHVINLWGADFDAEGELEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANPSIGMKKYFVGRNAHGKVAISAKK PG(SEQIDNO: IDNO:916) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1186) VRT-165 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKEMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:917) (SEQIDNO:1187) VRT-166 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKEMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:918) (SEQIDNO:1188) VRT-167 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNIAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:919) (SEQIDNO:1189) VRT-168 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGLYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNIAYYATPLLNGRGLYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:920) (SEQIDNO:1190) VRT-169 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:921) (SEQIDNO:1191) VRT-170 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:922) (SEQIDNO:1192) VRT-171 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:923) (SEQIDNO:1193) VRT-172 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKEMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:924) (SEQIDNO:1194) VRT-173 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNEAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNEAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:925) (SEQIDNO:1195) VRT-174 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNEAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRLIEDPTKNTSKINFFKE DGNEAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGTRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRLI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGTRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:926) (SEQIDNO:1196) VRT-175 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:927) (SEQIDNO:1197) VRT-176 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:928) (SEQIDNO:1198) VRT-177 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNIAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:929) (SEQIDNO:1199) VRT-178 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGLYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNIAYYATPLLNGRGLYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:930) (SEQIDNO:1200) VRT-179 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:931) (SEQIDNO:1201) VRT-180 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWING VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:932) (SEQIDNO:1202) VRT-181 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:933) (SEQIDNO:1203) VRT-182 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQV NO:934) (SEQIDNO:1204) VRT-183 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNEAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDPTKNTSKINFFKE DGNEAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:935) (SEQIDNO:1205) VRT-184 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNEAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDSD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENENGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRLIEDPTKNTSKINFFKE DGNEAYYATPLLNGRGFYDINKDFNRDSDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGTRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRLI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDPTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGTRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:936) (SEQIDNO:1206) VRT-185 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:937) (SEQIDNO:1207) VRT-186 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:938) (SEQIDNO:1208) VRT-187 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNIAYYATPLLNGRGWYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:939) (SEQIDNO:1209) VRT-188 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGLYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNIAYYATPLLNGRGLYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:940) (SEQIDNO:1210) VRT-189 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKDQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKDQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:941) (SEQIDNO:1211) VRT-190 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:942) (SEQIDNO:1212) VRT-191 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:943) (SEQIDNO:1213) VRT-192 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKEKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGWYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKEKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGWYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:944) (SEQIDNO:1214) VRT-193 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNEAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNEAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:945) (SEQIDNO:1215) VRT-194 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNEAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRLIEDSTKNTSKINFFKE DGNEAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEL AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGTRHSLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNYKYGRLI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE ELSVLLSEALYTGKAIGLSYGPAGTRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:946) (SEQIDNO:1216) VRT-195 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PGLSARRIGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGV TQGEDVFHAPYVANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IIFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVRINHVINLWGADFDS KAFPGLSARRIGVFPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDTNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYFVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVRINHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDTNASIGMKKYFVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:947) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1217) VRT-196 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG YNNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFNNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVFKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRYNNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFNNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYFVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYFVGINAHGHVAISAKK PG(SEQIDNO: IDNO:948) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1218) VRT-197 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNIAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNYKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNNHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQI 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:949) (SEQIDNO:1219) VRT-198 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAQFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAQF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLIN NNYKTTPPVLDSDG NLKAIYVTDSDSNASIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: SNASIGMKKYFVGVNSAGKVAISAKEIKEDNI PG(SEQIDNO: 950) GAQVLGLFTLSTGQDSWNQIN(SEQID 23) NO:1220) VRT-199 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAQFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SGGGGSG FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN (SEQID WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK NO: KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS 1021) TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKEG PGGGGSGGGGSGGGGSGGGGSGVTSVWTKGVT EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS PPAQFTQGEDVFHAPYVANQGWYDITKTFNGK QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD DDLLCGAATAGNMLHWWFDQNKDQIKRYLEEH NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA PEKQKINFNGEQMFDVKEAIDTKNHQLDSKLF SDIAVEWESNGQPE NVRINHVINLWGADFDSNG EYFKEKAFPYLSTKHLGVFPDHVIDMFINGYR NNYKTTPPVLDSDG NLKAIYVTDSDSNASIGMK LSLTNHGPTPVKEGSKDPRGGIFDAVFTRGDQ SFFLYSKLTVDKSR KYFVGVNSAGKVAISAKEI SKLLTSRHDFKEKNLKEISDLIKKELTEGKAL WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ GLSHTYANVRINHVINLWGADFDSNGNLKAIY ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: VTDSDSNASIGMKKYFVGVNSAGKVAISAKEI PG(SEQIDNO: 951) KEDNIGAQVLGLFTLSTGQDSWNQTN(SEQ 23) IDNO:1221) VRT-200 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAQFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1022) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKEG PGGGGSGGGGSGVTSVWTKGVTPPAQFTQGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VFHAPYVANQGWYDITKTFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GNMLHWWFDQNKDQIKRYLEEHPEKQKINFNG NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA EQMFDVKEAIDTKNHQLDSKLFEYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDSNG LSTKHLGVFPDHVIDMFINGYRLSLTNHGPTP NNYKTTPPVLDSDG NLKAIYVTDSDSNASIGMK VKEGSKDPRGGIFDAVFTRGDQSKLLTSRHDF SFFLYSKLTVDKSR KYFVGVNSAGKVAISAKEI KEKNLKEISDLIKKELTEGKALGLSHTYANVR WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ INHVINLWGADFDSNGNLKAIYVTDSDSNASI ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: GMKKYFVGVNSAGKVAISAKEIKEDNIGAQVL PG(SEQIDNO: 952) GLFTLSTGQDSWNQTN(SEQIDNO: 23) 1222) VRT-201 DKTHTCPPCPAPEA GGGGSGG ANQEIRYSEVTPYHVTSVW DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG TKGVTPPAQFTQGEDVFHA ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ PYVANQGWYDITKTFNGKD HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: DLLCGAATAGNMLHWWFDQ KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) NKDQIKRYLEEHPEKQKIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS FNGEQMFDVKEAIDTKNHQ WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE LDSKLFEYFKEKAFPYLST DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI KHLGVFPDHVIDMFINGYR PGGGGSGGGGSGGGGSGANQEIRYSEVTPYHV EKTISKAKGQPREP LSLTNHGPTPVKEGSKDPR TSVWTKGVTPPAQFTQGEDVFHAPYVANQGWY QVYTLPPSRDELTK GGIFDAVFTRGDQSKLLTS DITKTFNGKDDLLCGAATAGNMLHWWFDQNKD NQVSLTCLVKGFYP RHDFKEKNLKEISDLIKKE QIKRYLEEHPEKQKINFNGEQMFDVKEAIDTK SDIAVEWESNGQPE LTEGKALGLSHTYANVRIN NHQLDSKLFEYFKEKAFPYLSTKHLGVFPDHV NNYKTTPPVLDSDG HVINLWGADFDSNGNLKAI IDMFINGYRLSLTNHGPTPVKEGSKDPRGGIF SFFLYSKLTVDKSR YVTDSDSNASIGMKKYFVG DAVFTRGDQSKLLTSRHDFKEKNLKEISDLIK WQQGNVFSCSVMHE VNSAGKVAISAKEIKEDNI KELTEGKALGLSHTYANVRINHVINLWGADFD ALHNHYTQKSLSLS GAQVLGLFTLSTGQDSWNQ SNGNLKAIYVTDSDSNASIGMKKYFVGVNSAG PG(SEQIDNO: TN(SEQIDNO:953) KVAISAKEIKEDNIGAQVLGLFTLSTGQDSWN 23) QTN(SEQIDNO:1223) VRT-202 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAQFTQGE DKTHTAPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAQF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLTN NNYKTTPPVLDSDG NLKAIYVTDSDSNASIGMK HGPTPVKEGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQIN(SEQIDNO: SNASIGMKKYFVGVNSAGKVAISAKEIKEDNI PG(SEQIDNO: 954) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1224) VRT-203 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SGGGGSG KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN (SEQID LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK NO: KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS 1021) DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGGGGSGSQTEDSESLQ EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY RLRDIEDFQAEKKMQNVVYTKWLDGVDVKDHD QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE FRKIVDGNIAYYATPLLNGRGFYDINKDFNRD NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF NDKCAAAVAANMFHYWLDINRDNVDRFLRQNP SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG EKHGIIELPDGQLKLSDFLNTYESDHGYRDKS NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL KLFDFISNNFNGPVWTDKLLDNYINGYAYNYK SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL YGRTIEDSTKNTSKINFFKEVFNEKILTNNHS WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE IRNQNEFSVLLSEALYTGKAIGLSYGPAGLRH ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR SLGHIISVWGADLDADGNVVAIYVTDSDDKKL PG(SEQIDNO: GLWILDTGKYAWADYFDKT TIGDERVGLKRYKISTDDENRLRLTAYEETHN 23) EQTGTDQAEQ(SEQID TGGQIRGLWTLDTGKYAWADYFDKTEQTGTDQ NO:955) AEQ(SEQIDNO:1225) VRT-204 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID KDHDFRKIVDGNIAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1022) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGSQTEDSESLQRLRDIEDFQA EKTISKAKGQPREP WTDKLLDNYINGYAYNYKY EKKMQNVVYTKWLDGVDVKDHDFRKIVDGNIA QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE YYATPLLNGRGFYDINKDFNRDNDKCAAAVAA NQVSLTCLVKGFYP VFNEKILTNNHSIRNQNEF NMFHYWLDINRDNVDRFLRQNPEKHGIIELPD SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG GQLKLSDFLNTYESDHGYRDKSKLFDFISNNF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL NGPVWTDKLLDNYINGYAYNYKYGRTIEDSTK SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL NTSKINFFKEVFNEKILTNNHSIRNQNEFSVL WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE LSEALYTGKAIGLSYGPAGLRHSLGHIISVWG ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQIR ADLDADGNVVAIYVTDSDDKKLTIGDERVGLK PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RYKISTDDENRLRLTAYEETHNTGGQIRGLWT 23) EQTGTDQAEQ(SEQID LDTGKYAWADYFDKTEQTGTDQAEQ(SEQ NO:956) IDNO:1226) VRT-205 DKTHTCPPCPAPEA GGGGSGG RDIEDFQAEKKMQNVVYTK DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG WLDGVDVKDHDFRKIVDGN ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SGGGGSG IAYYATPLLNGRGFYDINK HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN (SEQID DFNRDNDKCAAAVAANMFH KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK NO: YWLDINRDNVDRFLRQNPE YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS 1021) KHGIIELPDGQLKLSDFLN WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE TYESDHGYRDKSKLFDFIS DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI NNFNGPVWTDKLLDNYING PGGGGSGGGGSGGGGSGGGGSGRDIEDFQAEK EKTISKAKGQPREP YAYNYKYGRTIEDSTKNTS KMQNVVYTKWLDGVDVKDHDFRKIVDGNIAYY QVYTLPPSRDELTK KINFFKEVFNEKILTNNHS ATPLLNGRGFYDINKDFNRDNDKCAAAVAANM NQVSLTCLVKGFYP IRNQNEFSVLLSEALYTGK FHYWLDINRDNVDRFLRQNPEKHGIIELPDGQ SDIAVEWESNGQPE AIGLSYGPAGLRHSLGHII LKLSDFLNTYESDHGYRDKSKLFDFISNNFNG NNYKTTPPVLDSDG SVWGADLDADGNVVAIYVT PVWTDKLLDNYINGYAYNYKYGRTIEDSTKNT SFFLYSKLTVDKSR DSDDKKLTIGDERVGLKRY SKINFFKEVFNEKILTNNHSIRNQNEFSVLLS WQQGNVFSCSVMHE KISTDDENRLRLTAYEETH EALYTGKAIGLSYGPAGLRHSLGHIISVWGAD ALHNHYTQKSLSLS NTGGQIRGLWTLDTGKYAW LDADGNVVAIYVTDSDDKKLTIGDERVGLKRY PG(SEQIDNO: ADYFDKTEQTGTDQAEQ KISTDDENRLRLTAYEETHNTGGQIRGLWTLD 23) (SEQIDNO:957) TGKYAWADYFDKTEQTGTDQAEQ(SEQID NO:1227) VRT-206 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAQFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQMFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTNHGPTPVKQG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAQF EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS TQGEDVFHAPYVANQGWYDITKTFNGKDDLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKQISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQMFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPYLSTKHLGVFPDHVIDMFINGYRLSLIN NNYKTTPPVLDSDG NLKAIYVTDSDSNASIGMK HGPTPVKQGSKDPRGGIFDAVFTRGDQSKLLT SFFLYSKLTVDKSR KYFVGVNSAGKVAISAKEI SRHDFKEKNLKQISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KQDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS QSWNQTN(SEQIDNO: SNASIGMKKYFVGVNSAGKVAISAKEIKQDNI PG(SEQIDNO: 958) GAQVLGLFTLSTGQQSWNQTN(SEQID 23) NO:1228) VRT-207 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TQGEDVFHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFKGEQLFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDTEASIGMK HGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: TEASIGMKKYVVGVNKAGKVAISAKEIKEDNI PG(SEQIDNO: 959) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1229) VRT-208 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TQGEDVFHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFKGEQLFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NARINHVINLWGADFDSNG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDTEPSIGMK HGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: TEPSIGMKKYVVGVNKAGKVAISAKEIKEDNI PG(SEQIDNO: 960) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1230) VRT-209 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TQGEDVFHAPYVANQGWYDITKLFNGKDTLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFKGEQLFDVKEAIDTKNHQLDSKLFEYFLE SDIAVEWESNGQPE NARINHVINLWGADFDSNG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDTEPSIGMK HGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: TEPSIGMKKYVVGVNKAGKVAISAKEIKEDNI PG(SEQIDNO: 961) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1231) VRT-210 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TQGEDVFHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQLFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDSNG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDTEASIGMK HGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: TEASIGMKKYVVGVNSAGKVAISAKEIKEDNI PG(SEQIDNO: 962) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1232) VRT-211 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TQGEDVFHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQLFDVKEAIDTKNHQLDSKLFEYFKE SDIAVEWESNGQPE NARINHVINLWGADFDSNG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDTEPSIGMK HGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: TEPSIGMKKYVVGVNSAGKVAISAKEIKEDNI PG(SEQIDNO: 963) GAQVLGLFTLSTGQDSWNQIN(SEQID 23) NO:1233) VRT-212 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPANFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKDQIKRYLEEHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKNHQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKEG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPANF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TQGEDVFHAPYVANQGWYDITKLFNGKDTLLC QVYTLPPSRDELTK KLLTSRHDFKEKNLKEISD GAATAGNMLHWWFDQNKDQIKRYLEEHPEKQK NQVSLTCLVKGFYP LIKKELTEGKALGLSHTYA INFNGEQLFDVKEAIDTKNHQLDSKLFEYFLE SDIAVEWESNGQPE NARINHVINLWGADFDSNG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLKAIYVTDSDTEPSIGMK HGPTPVKEGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSAGKVAISAKEI SRHDFKEKNLKEISDLIKKELTEGKALGLSHT WQQGNVFSCSVMHE KEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDSNGNLKAIYVTDSD ALHNHYTQKSLSLS DSWNQTN(SEQIDNO: TEPSIGMKKYVVGVNSAGKVAISAKEIKEDNI PG(SEQIDNO: 964) GAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1234) VRT-213 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PGLSARRIGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IIFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPGLSARRIGVFPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDTNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDTNASIGMKKYVVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:965) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1235) VRT-214 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PTLSARRIGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IIFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE TANVGINHVINLWGADFDS KAFPTLSARRIGVFPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDTNASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNSAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTTANVGINHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDTNASIGMKKYVVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:966) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1236) VRT-215 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNRKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PGLSARRIGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNRKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IIFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPGLSARRIGVFPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDTRASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNAAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDTRASIGMKKYVVGVNAAGKVAISAKEIKED PG(SEQIDNO: NO:967) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1237) VRT-216 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPAKFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNRKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEKIEAYLKKHPD KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKVIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGDQTNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PTLSARRIGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVYKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPAKF EKTISKAKGQPREP YQEKDRRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNRKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKNLKEI GAATAGNMLHWWFDQNKEKIEAYLKKHPDKQK NQVSLTCLVKGFYP SDLIKKELTEGKALGLSHT IIFGDQELLDVRKVINTKGDQTNSELFNYFRD SDIAVEWESNGQPE TANVGINHVINLWGADFDS KAFPTLSARRIGVFPDLVLDMFINGYYLNVYK NNYKTTPPVLDSDG NGNLKAIYVTDSDTRASIG TQTTDVNRTYQEKDRRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNAAGKVAISAK LTSRHDFKEKNLKEISDLIKKELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTTANVGINHVINLWGADFDSNGNLKAIYVTD ALHNHYTQKSLSLS GQDSWNQTN(SEQID SDTRASIGMKKYVVGVNAAGKVAISAKEIKED PG(SEQIDNO: NO:968) NIGAQVLGLFTLSTGQDSWNQTN(SEQID 23) NO:1238) VRT-217 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVFKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFRDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:969) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1239) VRT-218 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFLDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:970) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1240) VRT-219 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFLDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGELEAIYVTDSDAN NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGELEAI ALHNHYTQKSLSLS TLSSGKDQWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:971) IEGENIGAQVLGLFTLSSGKDQWQKLS(SEQ 23) IDNO:1241) VRT-220 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVFKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DENAEGNLEAIYVTDSDAN NVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:972) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1242) VRT-221 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDAN NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:973) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1243) VRT-222 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFRENNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGELEAIYVTDSDAN NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGELEAI ALHNHYTQKSLSLS TLSSGKDQWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:974) IEGENIGAQVLGLFTLSSGKDQWQKLS(SEQ 23) IDNO:1244) VRT-223 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVFKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFREYNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDTR NVFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDTRASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:975) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1245) VRT-224 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFREYNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGNLEAIYVTDSDTR NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGNLEAI ALHNHYTQKSLSLS TLSSGKDIWQKLS(SEQ YVTDSDTRASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:976) IEGENIGAQVLGLFTLSSGKDIWQKLS(SEQ 23) IDNO:1246) VRT-225 DKTHTCPPCPAPEA GGGGSGG QITSVWTKGVTPLTPEQFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVIHAPYLAHQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKTEIEAYLS KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDLK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSQLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNVPKTQSTD PGGGGSGGGGSGGGGSGQITSVWTKGVTPLTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EQFREYNEDVIHAPYLAHQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKTEIEAYLSKHP NQVSLTCLVKGFYP LNDISTIIKQELTEGRALA EKQKIIFGNQELFDLKAAIDTKDSQTNSQLFN SDIAVEWESNGQPE LSHTYANVRISHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFNAEGELEAIYVTDSDTR NVPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGHVA QTTLLTARHDLKNKGLNDISTIIKQELTEGRA WQQGNVFSCSVMHE ISAKKIEGENIGAQVLGLF LALSHTYANVRISHVINLWGADFNAEGELEAI ALHNHYTQKSLSLS TLSSGKDQWQKLS(SEQ YVTDSDTRASIGMKKYAVGINAHGHVAISAKK PG(SEQIDNO: IDNO:977) IEGENIGAQVLGLFTLSSGKDQWQKLS(SEQ 23) IDNO:1247) VRT-226 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:978) (SEQIDNO:1248) VRT-227 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:979) (SEQIDNO:1249) VRT-228 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDEQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNKPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDEQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNKPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:980) (SEQIDNO:1250) VRT-229 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKMQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDINR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDEQLKLSDFLNTYESDHG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENFNKPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKMQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDINRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDEQLKLSDFLNTYESDHGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNKPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS NRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKYAWADYFDKT RVGLKRYKISTDDENRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKYAWADYFDKTEQTGTDQAEQ NO:981) (SEQIDNO:1251) VRT-230 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFKGEQLFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEASIGMKKYVVGVNKNGKVAISAKEIEEDNI PG(SEQIDNO: 982) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1252) VRT-231 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFKGEQLFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNKNGKVAISAKEIEEDNI PG(SEQIDNO: 983) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1253) VRT-232 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKLFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFKGEQLFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNKNGKVAISAKEIEEDNI PG(SEQIDNO: 984) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1254) VRT-233 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEASIGMKKYVVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 985) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1255) VRT-234 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 986) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1256) VRT-235 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTNFTYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYVANQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTNF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS TYGEDVLHAPYVANQGWYDITKLFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA INFNGEQLFDVKEAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 987) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1257) VRT-236 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFKNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFKNQELFDLKAAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEASIGMKKYVVGVNKNGKVAISAKEIEEDNI PG(SEQIDNO: 988) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1258) VRT-237 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFKNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFKNQELFDLKAAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNKNGKVAISAKEIEEDNI PG(SEQIDNO: 989) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1259) VRT-238 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFKNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKLFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFKNQELFDLKAAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNKNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNKNGKVAISAKEIEEDNI PG(SEQIDNO: 990) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1260) VRT-239 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NVRINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEASIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANVRINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEASIGMKKYVVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 991) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1261) VRT-240 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKTFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFKE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 992) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1262) VRT-241 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDTLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEQIENYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFNNQELFDLKAAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFEYFLEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PSLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLLNHGPTPVKRG PGGGGSGGGGSGGGGSGVTSVWTKGVTPPTDF EKTISKAKGQPREP SKDKRGGIFDAVFTRGVQS IYGEDVLHAPYKAGQGWYDITKLFNGKDTLLC QVYTLPPSRDELTK KLLTNRHDFKEKTLKEISD GAATAGNMLHWWFDQNKEQIENYLKKHPEKQK NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA IIFNNQELFDLKAAIDTKDSQLDSKLFEYFLE SDIAVEWESNGQPE NARINHVINLWGADFDAEG KAFPSLSTKHLGVFPDHVIDMFINGYRLSLLN NNYKTTPPVLDSDG NLEAIYVTDSDTEPSIGMK HGPTPVKRGSKDKRGGIFDAVFTRGVQSKLLT SFFLYSKLTVDKSR KYVVGVNSNGKVAISAKEI NRHDFKEKTLKEISDLIKQELTEGKALGISHT WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ YANARINHVINLWGADFDAEGNLEAIYVTDSD ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: TEPSIGMKKYVVGVNSNGKVAISAKEIEEDNI PG(SEQIDNO: 993) GAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1263) VRT-242 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IIFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPNLSARRLGVFPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDTNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDTNASIGMKKYVVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:994) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1264) VRT-243 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNGKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PTLSARRLGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNGKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IIFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE TANVGINHVINLWGADFDS KAFPTLSARRLGVFPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDTNASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNSAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTTANVGINHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDTNASIGMKKYVVGVNSAGKVAISAKEIKED PG(SEQIDNO: NO:995 NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1265) VRT-244 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNRKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PNLSARRLGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNRKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IIFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE YANVGINHVINLWGADFDS KAFPNLSARRLGVFPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDTRASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNAAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTYANVGINHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDTRASIGMKKYVVGVNAAGKVAISAKEIKED PG(SEQIDNO: NO:996) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1266) VRT-245 DKTHTCPPCPAPEA GGGGSGG VTSVWTKGVTPPADFTQGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG DVFHAPYKANQGWYDITKT ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ FNRKDNLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: WWFDQNKEYIEAYLKKHPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KQKIIFGDQELLDVRKAIN YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKGSQKNSELFNYFRDKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PTLSARRLGVFPDLVLDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYYLNVTKTQTTDVNRT PGGGGSGGGGSGGGGSGVTSVWTKGVTPPADF EKTISKAKGQPREP YQEKDKRGGIFDAVFTRGV TQGEDVFHAPYKANQGWYDITKTFNRKDNLLC QVYTLPPSRDELTK QSKLLTSRHDFKEKGLKEI GAATAGNMLHWWFDQNKEYIEAYLKKHPEKQK NQVSLTCLVKGFYP SDLIKQELTEGKALGLSHT IIFGDQELLDVRKAINTKGSQKNSELFNYFRD SDIAVEWESNGQPE TANVGINHVINLWGADFDS KAFPTLSARRLGVFPDLVLDMFINGYYLNVTK NNYKTTPPVLDSDG DGNLKAIYVTDSDTRASIG TQTTDVNRTYQEKDKRGGIFDAVFTRGVQSKL SFFLYSKLTVDKSR MKKYVVGVNAAGKVAISAK LTSRHDFKEKGLKEISDLIKQELTEGKALGLS WQQGNVFSCSVMHE EIKEDNIGAQVLGLFTLST HTTANVGINHVINLWGADFDSDGNLKAIYVTD ALHNHYTQKSLSLS GQDIWNQTN(SEQID SDTRASIGMKKYVVGVNAAGKVAISAKEIKED PG(SEQIDNO: NO:997) NIGAQVLGLFTLSTGQDIWNQTN(SEQID 23) NO:1267) VRT-246 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:998) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1268) VRT-247 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:999) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1269) VRT-248 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1000) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1270) VRT-249 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1001) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1271) VRT-250 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1002) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1272) VRT-251 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1003) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1273) VRT-252 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLGKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFREYNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDTR NLGKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDTRASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1004) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1274) VRT-253 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFREYNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLIAIYVTDSDTR NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLIAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDTRASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1005) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1275) VRT-254 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVLHAPYVANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKTFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFREYNEDVLHAPYVANQGWYDITKTFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELIAIYVTDSDTR NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGVNANGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELIAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDTRASIGMKKYAVGVNANGKVAISAKK PG(SEQIDNO: IDNO:1006) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1276) VRT-255 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLFKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1007) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1277) VRT-256 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1008) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1278) VRT-257 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVMPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVMPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELEAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELEAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1009) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1279) VRT-258 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLFKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DEDAEGNLEAIYVTDSDAN NLFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1010) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1280) VRT-259 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1011) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1281) VRT-260 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFRENNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELEAIYVTDSDAN NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELEAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDANASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1012) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1282) VRT-261 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLFKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFREYNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFRDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDTR NLFKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDTRASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1013) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1283) VRT-262 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFREYNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDTR NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGNLEAI ALHNHYTQKSLSLS TLSTGQDIWQKLS(SEQ YVTDSDTRASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1014) IEGDNIGAQVLGLFTLSTGQDIWQKLS(SEQ 23) IDNO:1284) VRT-263 DKTHTCPPCPAPEA GGGGSGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG EYNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFNYFL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPGLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNLPKTQSTD PGGGGSGGGGSGGGGSGTITSVWTKGVTPPTP EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF EDFREYNEDVLHAPYLANQGWYDITKAFDGKD QVYTLPPSRDELTK TRGVQTTLLTARHDLKNKG NLLCGAATAGNMLHWWFDQNKEEIERYLKKHP NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA EKQKIIFGNQELFDVKAAIDTKDSQTNSKLFN SDIAVEWESNGQPE LSHTYANVRINHVINLWGA YFLDKAFPGLSARQLGVFPDLVLDMFINGYYL NNYKTTPPVLDSDG DFDAEGELEAIYVTDSDTR NLPKTQSTDVNRPYQDKDKRGGIFDAVFTRGV SFFLYSKLTVDKSR ASIGMKKYAVGINAHGKVA QTTLLTARHDLKNKGLNEISDLIKQELTEGKA WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF LALSHTYANVRINHVINLWGADFDAEGELEAI ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ YVTDSDTRASIGMKKYAVGINAHGKVAISAKK PG(SEQIDNO: IDNO:1015) IEGDNIGAQVLGLFTLSTGQDQWQKLS(SEQ 23) IDNO:1285) VRT-264 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:1016) (SEQIDNO:1286) VRT-265 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDGQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENENGPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDGQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNGPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:1017) (SEQIDNO:1287) VRT-266 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDEQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISNNFNKPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLSEALYTGKAIGLSYG IELPDEQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHSLGHIISVWGADL ISNNFNKPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLSEALYTGKAIGLSYGPAGLRHSLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:1018) (SEQIDNO:1288) VRT-267 DKTHTCPPCPAPEA GGGGSGG SQTEDSESLQRLRDIEDFQ DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GGSGGGG AEKKKQNVVYTKWLDGVDV ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV SG(SEQ KDHDFRKIVDGNSAYYATP HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN IDNO: LLNGRGFYDINKDFNRDND KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1020) KCAAAVAANMFHYWLDRNR YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS DNVDRFLRQNPEKHGIIEL WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PDEQLKLSDFLNTYESDDG DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI YRDKSKLFDFISENENKPV PGGGGSGGGGSGGGGSGSQTEDSESLQRLRDI EKTISKAKGQPREP WTDKLLDNYINGYAYNSKY EDFQAEKKKQNVVYTKWLDGVDVKDHDFRKIV QVYTLPPSRDELTK GRTIEDSTKNTSKINFFKE DGNSAYYATPLLNGRGFYDINKDFNRDNDKCA NQVSLTCLVKGFYP VFNEKILTNIHSIRNQNEF AAVAANMFHYWLDRNRDNVDRFLRQNPEKHGI SDIAVEWESNGQPE SVLLIEALYTGKAIGLSYG IELPDEQLKLSDFLNTYESDDGYRDKSKLFDF NNYKTTPPVLDSDG PAGLRHGLGHIISVWGADL ISENFNKPVWTDKLLDNYINGYAYNSKYGRTI SFFLYSKLTVDKSR DADGNVVAIYVTDSDDKKL EDSTKNTSKINFFKEVFNEKILTNIHSIRNQN WQQGNVFSCSVMHE TIGDERVGLKRYKISTDDE EFSVLLIEALYTGKAIGLSYGPAGLRHGLGHI ALHNHYTQKSLSLS GRLRLTAYEETHNTGGQVR ISVWGADLDADGNVVAIYVTDSDDKKLTIGDE PG(SEQIDNO: GLWTLDTGKQAWADYFDKT RVGLKRYKISTDDEGRLRLTAYEETHNTGGQV 23) EQTGTDQAEQ(SEQID RGLWTLDTGKQAWADYFDKTEQTGTDQAEQ NO:1019) (SEQIDNO:1289) VRT-268 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIKNYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIKNYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1291) GLFTLSTGQDIWNQTN(SEQIDNO: 23) 1311) VRT-269 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIKNYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFGGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIKNYLKKYPEKQKINFGG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1292) GLFTLSTGQDIWNQTN(SEQIDNO: 23) 1312) VRT-270 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVINSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVINSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1300) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1313) VRT-271 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSNSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSNSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1301) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1314) VRT-272 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVINSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVINSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1293) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1315) VRT-273 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSNSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSNSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1294) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1316) VRT-274 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIKNYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIKNYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1302) GLFTLSTGQDIWNQTN(SEQIDNO: 23) 1317) VRT-275 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIKNYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFGGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIKNYLKKYPEKQKINFGG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1303) GLFTLSTGQDIWNQTN(SEQIDNO: 23) 1318) VRT-276 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTNSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVINSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1304) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1319) VRT-277 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSNSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVTDSNSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1305) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1320) VRT-278 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVINSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVINSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1306) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1321) VRT-279 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLENGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSNSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVTDSNSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1307) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1322) VRT-280 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIKNYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIKNYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1296) GLFTLSTGQDIWNQTN(SEQIDNO: 23) 1323) VRT-281 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIKNYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFGGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIKNYLKKYPEKQKINFGG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWNQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1297) GLFTLSTGQDIWNQTN(SEQIDNO: 23) 1324) VRT-282 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVINSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVINSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1308) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1325) VRT-283 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFNGEQLEDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINENG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSNSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSNSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1309) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1326) VRT-284 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTNSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVINSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1298) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1327) VRT-285 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSNSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSNSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1299) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1328) VRT-286 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRIGHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLINRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ IGHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1310) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1329) VRT-317 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NVRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANVR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1290) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1334) VRT-318 DKTHTCPPCPAPEA GGGSKGG VTSVWTKGVTPPTDFIYGE DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK DVLHAPYKAGQGWYDITKL ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID FNGKDDLLCGAATAGNMLH HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: WWFDQNKEQIENYLKKYPE KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KQKINFKGEQLFDVKEAID YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS TKDSQLDSKLFDYFKEKAF WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE PYLSTKHLGVFPDHVIDMF DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI INGYRLSLTDHGPTPVKRG PGGGGSKGGGSKVTSVWTKGVTPPTDFIYGED EKTISKAKGQPREP SKDPRGGIFDAVFTRGDQS VLHAPYKAGQGWYDITKLFNGKDDLLCGAATA QVYTLPPSRDELTK KLLTNRYDLKEKTLKEISD GNMLHWWFDQNKEQIENYLKKYPEKQKINFKG NQVSLTCLVKGFYP LIKQELTEGKALGISHTYA EQLFDVKEAIDTKDSQLDSKLFDYFKEKAFPY SDIAVEWESNGQPE NGRINHVINLWGADFDAEG LSTKHLGVFPDHVIDMFINGYRLSLTDHGPTP NNYKTTPPVLDSDG NLEAIYVTDSDSNPSIGMK VKRGSKDPRGGIFDAVFTRGDQSKLLTNRYDL SFFLYSKLTVDKSR KYFVGVNSSGKVAISAKEI KEKTLKEISDLIKQELTEGKALGISHTYANGR WQQGNVFSCSVMHE EEDNIGAQVLGLFTLSTGQ INHVINLWGADFDAEGNLEAIYVTDSDSNPSI ALHNHYTQKSLSLS DIWQQTN(SEQIDNO: GMKKYFVGVNSSGKVAISAKEIEEDNIGAQVL PG(SEQIDNO: 1295) GLFTLSTGQDIWQQTN(SEQIDNO: 23) 1335) VRT-319 DKTHTCPPCPAPEA GGGSKGG TITSVWTKGVTPPTPEDFR DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLM AGAPSVFLFPPKPK GSK ENNEDVLHAPYLANQGWYD ISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEV DTLMISRTPEVTCV (SEQID ITKAFDGKDNLLCGAATAG HNAKTKPREEQQNSTYRVVSVLTVLHQDWLNG VVDVSHEDPEVKFN NO: NMLHWWFDQNKEEIERYLK KEYKCKVSNKALKAPIEKTISKAKGQPREPQV WYVDGVEVHNAKTK 1330) KHPEKQKIIFGNQELFDVK YTLPPSRDELTKNQVSLTCLVKGFYPSDIAVE PREEQQNSTYRVVS AAIDTKDSQTNSKLFDYFR WESNGQPENNYKTTPPVLDSDGSFFLYSKLTV VLTVLHQDWLNGKE DKAFPNLSARQLGVFPDLV DKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS YKCKVSNKALKAPI LDMFINGYYLNGGKTQSTD PGGGGSKGGGSKTITSVWTKGVTPPTPEDFRE EKTISKAKGQPREP VNRPYQDKDKRGGIFDAVF NNEDVLHAPYLANQGWYDITKAFDGKDNLLCG QVYTLPPSRDELTK TRGDQTTLLTARHDLKNKG AATAGNMLHWWFDQNKEEIERYLKKHPEKQKI NQVSLTCLVKGFYP LNEISDLIKQELTEGKALA IFGNQELFDVKAAIDTKDSQTNSKLFDYFRDK SDIAVEWESNGQPE LSHTYANVRINHVINLWGA AFPNLSARQLGVFPDLVLDMFINGYYLNGGKT NNYKTTPPVLDSDG DFDAEGNLEAIYVTDSDAN QSTDVNRPYQDKDKRGGIFDAVFTRGDQTTLL SFFLYSKLTVDKSR PSIGMKKYFVGVNAHGKVA TARHDLKNKGLNEISDLIKQELTEGKALALSH WQQGNVFSCSVMHE ISAKKIEGDNIGAQVLGLF TYANVRINHVINLWGADFDAEGNLEAIYVTDS ALHNHYTQKSLSLS TLSTGQDQWQKLS(SEQ DANPSIGMKKYFVGVNAHGKVAISAKKIEGDN PG(SEQIDNO: IDNO:1333) IGAQVLGLFTLSTGQDQWQKLS(SEQID 23) NO:1336)

TABLE-US-00014 TABLE9 C-terminus ID N-terminusIdes Fc His-tag VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT DKTHTCPPCPAPEAAGAPSVEL HHHHHHHH 287 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV (SEQID CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN NO:27) KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLIV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:26) LSLSPG(SEQIDNO:23) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT DKTHTCPPCPAPEAAGAPSVEL HHHHHHHH 288 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV (SEQID CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN NO:27) KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLIV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLINHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLWCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:26) LSLSPG(SEQIDNO: 24) VRT- ANQEIRYSEVTPYHVTSVWTKNVTPPAQFT DKTHTCPPCPAPEAAGAPSVFL HHHHHHHH 289 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV (SEQID CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN NO:27) KQKINFNGSQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLNNSGPTPVKNGSKDPRGGIFDAVFT PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKNKSLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGTLKAIYVTDSDSNASIGMKKYFVGVNNA VLDSDGSFFLYSKLTVDKSRWQ TKVAISAKEIKENNTGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:28) LSLSPG(SEQIDNO: 23) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT DKTHTCPPCPAPEAAGAPSVEL HHHHHHHH 290 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV (SEQID CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN NO:27) KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNAQIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:29) LSLSPG(SEQIDNO: 23) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT DKTHTCPPCPAPEAAGAPSVFL (N/A) 291 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLIV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:26) LSLSPG(SEQIDNO: 23) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT DKTHTCPPCPAPEAAGAPSVEL (N/A) 292 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLIV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLWCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:26) LSLSPG(SEQIDNO: 24) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT DKTHTCPPCPAPEAAGAPSVFL (N/A) 293 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLIV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLINHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNAQIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:29) LSLSPG(SEQIDNO: 23) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTSPPCPAPEAAGAPSVFL (N/A) 294 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLINHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 42) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTSPPSPAPEAAGAPSVFL (N/A) 295 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 43) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTCPPCPAPELLGDSGVFL (N/A) 296 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHDEPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQYNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALPR YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLWCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 44) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTCPPCPAPEFEGGPSVFL (N/A) 297 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSDEDGEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQYNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALAA YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLSCAVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLVSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 45) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTCPPCPAPEFEGGPSVFL (N/A) 298 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSQEDPEVQFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQFNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALPS YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT SIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLWCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 46 VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTCPPCPAPEFEGGPSVFL (N/A) 299 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSDEDGEVQFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQFNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALAS YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT SIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLSCAVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLVSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 47 VRT- RNATEAYAKEVPHQITSVWTKGVTPLTPEQ DKTHTSPPCPAPEAAGAPSVFL (N/A) 300 FRYNNEDVIHAPYLAHQGWYDITKAFDGKD FPPKPKDTLMISRTPEVTCVVV NLLCGAATAGNMLHWWFDQNKTEIEAYLSK DVSHEDPEVKFNWYVDGVEVHN HPEKQKIIFNNQELFDLKAAIDTKDSQTNS AKTKPREEQQNSTYRVVSVLIV QLFNYFRDKAFPNLSARQLGVMPDLVLDMF LHQDWLNGKEYKCKVSNKALKA INGYYLNVFKTQSTDVNRPYQDKDKRGGIF PIEKTISKAKGQPREPQVYTLP DAVFTRGDQTTLLTARHDLKNKGLNDISTI PSRDELTKNQVSLTCLVKGFYP IKQELTEGRALALSHTYANVSISHVINLWG SDIAVEWESNGQPENNYKTTPP ADFNAEGNLEAIYVIDSDANASIGMKKYFV VLDSDGSFFLYSKLTVDKSRWQ GINAHGHVAISAKKIEGENIGAQVLGLFTL QGNVFSCSVMHEALHNHYTQKS SSGKDIWQKLS(SEQIDNO:52) LSLSPGK(SEQIDNO: 42) VRT- ANQEIRYSNVTPYHVTSVWTKGVTPPANFT DKTHTCPPCPAPEAAGAPSVFL (N/A) 301 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADFDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:50) LSLSPGK(SEQIDNO: 19) VRT- ANQEIRYSEVTPYHNTSVWTKGVTPPANFT DKTHTCPPCPAPEAAGAPSVFL (N/A) 302 QGEDVFHAPYVANQGWYDITKTENGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQQNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALKA YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGSLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:51) LSLSPGK(SEQIDNO: 19) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTSPPCPAPEAAGAPSVFL (N/A) 303 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQYNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALPA YRLSLINHGPTPVKEGSKDPRGGIFDAVET PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 48) VRT- ANQEIRYSEVTPYHVTSVWTKGVTPPANFT DKTHTSPPCPAPELLGGPSVFL (N/A) 304 QGEDVFHAPYVANQGWYDITKTFNGKDDLL FPPKPKDTLMISRTPEVTCVVV CGAATAGNMLHWWFDQNKDQIKRYLEEHPE DVSHEDPEVKFNWYVDGVEVHN KQKINFNGEQMFDVKEAIDTKNHQLDSKLF AKTKPREEQYNSTYRVVSVLTV EYFKEKAFPYLSTKHLGVFPDHVIDMFING LHQDWLNGKEYKCKVSNKALPA YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PIEKTISKAKGQPREPQVYTLP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL PSRDELTKNQVSLTCLVKGFYP TEGKALGLSHTYANVRINHVINLWGADEDS SDIAVEWESNGQPENNYKTTPP NGNLKAIYVTDSDSNASIGMKKYFVGVNSA VLDSDGSFFLYSKLTVDKSRWQ GKVAISAKEIKEDNIGAQVLGLFTLSTGQD QGNVFSCSVMHEALHNHYTQKS SWNQTN(SEQIDNO:36) LSLSPGK(SEQIDNO: 49)

TABLE-US-00015 TABLE10 C-terminus ID Fc C-terminusIdeS His-tag VRT- DKTHTCPPCPAPEAAGAPSVFL ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT HHHHHHHH 305 FPPKPKDTLMISRTPEVTCVVV QGEDVFHAPYVANQGWYDITKTFNGKDDLL (SEQID DVSHEDPEVKFNWYVDGVEVHN CGAATAGNMLHWWFDQNKDQIKRYLEEHPE NO:27) AKTKPREEQQNSTYRVVSVLTV KQKINFNGEQMFDVKEAIDTKNHQLDSKLF LHQDWLNGKEYKCKVSNKALKA EYFKEKAFPYLSTKHLGVFPDHVIDMFING PIEKTISKAKGQPREPQVYTLP YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PSRDELTKNQVSLTCLVKGFYP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL SDIAVEWESNGQPENNYKTTPP TEGKALGLSHTYANVRINHVINLWGADFDS VLDSDGSFFLYSKLTVDKSRWQ NGNLKAIYVTDSDSNASIGMKKYFVGVNSA QGNVFSCSVMHEALHNHYTQKS GKVAISAKEIKEDNIGAQVLGLFTLSTGQD LSLSPG(SEQIDNO: SWNQTN(SEQIDNO:26) 23) VRT- DKTHTCPPCPAPEAAGAPSVFL ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT HHHHHHHH 306 FPPKPKDTLMISRTPEVTCVVV QGEDVFHAPYVANQGWYDITKTFNGKDDLL (SEQID DVSHEDPEVKFNWYVDGVEVHN CGAATAGNMLHWWFDQNKDQIKRYLEEHPE NO:27) AKTKPREEQQNSTYRVVSVLTV KQKINFNGEQMFDVKEAIDTKNHQLDSKLF LHQDWLNGKEYKCKVSNKALKA EYFKEKAFPYLSTKHLGVFPDHVIDMFING PIEKTISKAKGQPREPQVYTLP YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PSRDELTKNQVSLWCLVKGFYP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL SDIAVEWESNGQPENNYKTTPP TEGKALGLSHTYANVRINHVINLWGADEDS VLDSDGSFFLYSKLTVDKSRWQ NGNLKAIYVTDSDSNASIGMKKYFVGVNSA QGNVFSCSVMHEALHNHYTQKS GKVAISAKEIKEDNIGAQVLGLFTLSTGQD LSLSPG(SEQIDNO: SWNQTN(SEQIDNO:26) 24) VRT- DKTHTCPPCPAPEAAGAPSVFL ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT HHHHHHHH 307 FPPKPKDTLMISRTPEVTCVVV QGEDVFHAPYVANQGWYDITKTFNGKDDLL (SEQID DVSHEDPEVKFNWYVDGVEVHN CGAATAGNMLHWWFDQNKDQIKRYLEEHPE NO:27) AKTKPREEQQNSTYRVVSVLTV KQKINFNGEQMFDVKEAIDTKNHQLDSKLF LHQDWLNGKEYKCKVSNKALKA EYFKEKAFPYLSTKHLGVFPDHVIDMFING PIEKTISKAKGQPREPQVYTLP YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PSRDELTKNQVSLTCLVKGFYP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL SDIAVEWESNGQPENNYKTTPP TEGKALGLSHTYANVRINHVINLWGADFDS VLDSDGSFFLYSKLTVDKSRWQ NGNLKAIYVTDSDSNAQIGMKKYFVGVNSA QGNVFSCSVMHEALHNHYTQKS GKVAISAKEIKEDNIGAQVLGLFTLSTGQD LSLSPG(SEQIDNO: SWNQTN(SEQIDNO:29) 23) VRT- DKTHTCPPCPAPEAAGAPSVEL ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT (N/A) 308 FPPKPKDTLMISRTPEVTCVVV QGEDVFHAPYVANQGWYDITKTFNGKDDLL DVSHEDPEVKFNWYVDGVEVHN CGAATAGNMLHWWFDQNKDQIKRYLEEHPE AKTKPREEQQNSTYRVVSVLTV KQKINFNGEQMFDVKEAIDTKNHQLDSKLF LHQDWLNGKEYKCKVSNKALKA EYFKEKAFPYLSTKHLGVFPDHVIDMFING PIEKTISKAKGQPREPQVYTLP YRLSLTNHGPTPVKEGSKDPRGGIFDAVET PSRDELTKNQVSLTCLVKGFYP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL SDIAVEWESNGQPENNYKTTPP TEGKALGLSHTYANVRINHVINLWGADEDS VLDSDGSFFLYSKLTVDKSRWQ NGNLKAIYVTDSDSNASIGMKKYFVGVNSA QGNVFSCSVMHEALHNHYTQKS GKVAISAKEIKEDNIGAQVLGLFTLSTGQD LSLSPG(SEQIDNO: SWNQTN(SEQIDNO:26) 23) VRT- DKTHTCPPCPAPEAAGAPSVFL ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT (N/A) 309 FPPKPKDTLMISRTPEVTCVVV QGEDVFHAPYVANQGWYDITKTFNGKDDLL DVSHEDPEVKFNWYVDGVEVHN CGAATAGNMLHWWFDQNKDQIKRYLEEHPE AKTKPREEQQNSTYRVVSVLTV KQKINFNGEQMFDVKEAIDTKNHQLDSKLF LHQDWLNGKEYKCKVSNKALKA EYFKEKAFPYLSTKHLGVFPDHVIDMFING PIEKTISKAKGQPREPQVYTLP YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PSRDELTKNQVSLWCLVKGFYP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL SDIAVEWESNGQPENNYKTTPP TEGKALGLSHTYANVRINHVINLWGADFDS VLDSDGSFFLYSKLTVDKSRWQ NGNLKAIYVTDSDSNASIGMKKYFVGVNSA QGNVFSCSVMHEALHNHYTQKS GKVAISAKEIKEDNIGAQVLGLFTLSTGQD LSLSPG(SEQIDNO: SWNQTN(SEQIDNO:26) 24) VRT- DKTHTCPPCPAPEAAGAPSVEL ANQEIRYSEVTPYHVTSVWTKGVTPPAQFT (N/A) 310 FPPKPKDTLMISRTPEVTCVVV QGEDVFHAPYVANQGWYDITKTFNGKDDLL DVSHEDPEVKFNWYVDGVEVHN CGAATAGNMLHWWFDQNKDQIKRYLEEHPE AKTKPREEQQNSTYRVVSVLIV KQKINFNGEQMFDVKEAIDTKNHQLDSKLF LHQDWLNGKEYKCKVSNKALKA EYFKEKAFPYLSTKHLGVFPDHVIDMFING PIEKTISKAKGQPREPQVYTLP YRLSLTNHGPTPVKEGSKDPRGGIFDAVFT PSRDELTKNQVSLTCLVKGFYP RGDQSKLLTSRHDFKEKNLKEISDLIKKEL SDIAVEWESNGQPENNYKTTPP TEGKALGLSHTYANVRINHVINLWGADFDS VLDSDGSFFLYSKLTVDKSRWQ NGNLKAIYVTDSDSNAQIGMKKYFVGVNSA QGNVFSCSVMHEALHNHYTQKS GKVAISAKEIKEDNIGAQVLGLFTLSTGQD LSLSPG(SEQIDNO: SWNQTN(SEQIDNO:29) 23)

TABLE-US-00016 TABLE11 C-terminus ID C-terminusIdeS Fc C-terminusIdeS His-tag VRT- ANQEIRYSEVTPYHVTSV DKTHTCPPCPAPEA ANQEIRYSEVTPYHVTSV HHHHHHHH 311 WTKGVTPPAQFTQGEDVF AGAPSVFLFPPKPK WTKGVTPPAQFTQGEDVF (SEQID HAPYVANQGWYDITKTEN DTLMISRTPEVTCV HAPYVANQGWYDITKTEN NO:27) GKDDLLCGAATAGNMLHW VVDVSHEDPEVKFN GKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPE WYVDGVEVHNAKTK WFDQNKDQIKRYLEEHPE KQKINFNGEQMFDVKEAI PREEQQNSTYRVVS KQKINFNGEQMFDVKEAI DTKNHQLDSKLFEYFKEK VLTVLHQDWLNGKE DTKNHQLDSKLFEYFKEK AFPYLSTKHLGVFPDHVI YKCKVSNKALKAPI AFPYLSTKHLGVFPDHVI DMFINGYRLSLTNHGPTP EKTISKAKGQPREP DMFINGYRLSLTNHGPTP VKEGSKDPRGGIFDAVET QVYTLPPSRDELTK VKEGSKDPRGGIFDAVET RGDQSKLLTSRHDFKEKN NQVSLTCLVKGFYP RGDQSKLLTSRHDFKEKN LKEISDLIKKELTEGKAL SDIAVEWESNGQPE LKEISDLIKKELTEGKAL GLSHTYANVRINHVINLW NNYKTTPPVLDSDG GLSHTYANVRINHVINLW GADFDSNGNLKAIYVTDS SFFLYSKLTVDKSR GADFDSNGNLKAIYVTDS DSNASIGMKKYFVGVNSA WQQGNVFSCSVMHE DSNASIGMKKYFVGVNSA GKVAISAKEIKEDNIGAQ ALHNHYTQKSLSLS GKVAISAKEIKEDNIGAQ VLGLFTLSTGQDSWNQTN PG(SEQID VLGLFTLSTGQDSWNQTN (SEQIDNO:26) NO:23) (SEQIDNO:26) VRT- ANQEIRYSEVTPYHVTSV DKTHTCPPCPAPEA ANQEIRYSEVTPYHVTSV (N/A) 312 WTKGVTPPAQFTQGEDVF AGAPSVFLFPPKPK WTKGVTPPAQFTQGEDVE HAPYVANQGWYDITKTEN DTLMISRTPEVTCV HAPYVANQGWYDITKTEN GKDDLLCGAATAGNMLHW VVDVSHEDPEVKFN GKDDLLCGAATAGNMLHW WFDQNKDQIKRYLEEHPE WYVDGVEVHNAKTK WFDQNKDQIKRYLEEHPE KQKINFNGEQMFDVKEAI PREEQQNSTYRVVS KQKINFNGEQMEDVKEAI DTKNHQLDSKLFEYFKEK VLTVLHQDWLNGKE DTKNHQLDSKLFEYFKEK AFPYLSTKHLGVFPDHVI YKCKVSNKALKAPI AFPYLSTKHLGVFPDHVI DMFINGYRLSLTNHGPTP EKTISKAKGQPREP DMFINGYRLSLINHGPTP VKEGSKDPRGGIFDAVET QVYTLPPSRDELTK VKEGSKDPRGGIFDAVFT RGDQSKLLTSRHDFKEKN NQVSLTCLVKGFYP RGDQSKLLTSRHDFKEKN LKEISDLIKKELTEGKAL SDIAVEWESNGQPE LKEISDLIKKELTEGKAL GLSHTYANVRINHVINLW NNYKTTPPVLDSDG GLSHTYANVRINHVINLW GADFDSNGNLKAIYVTDS SFFLYSKLTVDKSR GADFDSNGNLKAIYVTDS DSNASIGMKKYFVGVNSA WQQGNVFSCSVMHE DSNASIGMKKYFVGVNSA GKVAISAKEIKEDNIGAQ ALHNHYTQKSLSLS GKVAISAKEIKEDNIGAQ VLGLFTLSTGQDSWNQTN PG(SEQID VLGLFTLSTGQDSWNQTN (SEQIDNO:26) NO:23) (SEQIDNO:26)

TABLE-US-00017 TABLE12 N-terminus C-terminus ID VHH N-terminusIdeS Fc His-tag VRT- QVQLQESGGG ANQEIRYSEVTPYHVTSVWTKGV DKTHTCPPCPAPEAAGA HHHHHHHH 313 LVQAGGSLRL TPPAQFTQGEDVFHAPYVANQGW PSVFLFPPKPKDTLMIS (SEQID SCAASGYISD YDITKTFNGKDDLLCGAATAGNM RTPEVTCVVVDVSHEDP NO:27) AYYMGWYRQA LHWWFDONKDQIKRYLEEHPEKQ EVKFNWYVDGVEVHNAK PGKEREFVAT KINFNGEQMFDVKEAIDTKNHQL TKPREEQQNSTYRVVSV ITHGTNTYYA DSKLFEYFKEKAFPYLSTKHLGV LTVLHQDWLNGKEYKCK DSVKGRFTIS FPDHVIDMFINGYRLSLTNHGPT VSNKALKAPIEKTISKA RDNAKNTVYL PVKEGSKDPRGGIFDAVETRGDQ KGQPREPQVYTLPPSRD QMNSLKPEDT SKLLTSRHDFKEKNLKEISDLIK ELTKNQVSLTCLVKGFY AVYYCAVLET KELTEGKALGLSHTYANVRINHV PSDIAVEWESNGOPENN RSYSFRYWGQ INLWGADFDSNGNLKAIYVTDSD YKTTPPVLDSDGSFFLY GTQVTVSSLE SNAQIGMKKYFVGVNSAGKVAIS SKLTVDKSRWQQGNVFS GGGGS(SEQ AKEIKEDNIGAQVLGLFTLSTGQ CSVMHEALHNHYTQKSL IDNO:30) DSWNQTN(SEQIDNO: SLSPG(SEQID 29) NO:23) VRT- QVQLQESGGG ANQEIRYSEVTPYHVTSVWTKGV DKTHTCPPCPAPEAAGA (N/A) 314 LVQAGGSLRL TPPAQFTQGEDVFHAPYVANQGW PSVFLFPPKPKDTLMIS SCAASGYISD YDITKTFNGKDDLLCGAATAGNM RTPEVTCVVVDVSHEDP AYYMGWYRQA LHWWFDQNKDQIKRYLEEHPEKQ EVKFNWYVDGVEVHNAK PGKEREFVAT KINFNGEQMEDVKEAIDTKNHQL TKPREEQQNSTYRVVSV ITHGTNTYYA DSKLFEYFKEKAFPYLSTKHLGV LTVLHQDWLNGKEYKCK DSVKGRFTIS FPDHVIDMFINGYRLSLINHGPT VSNKALKAPIEKTISKA RDNAKNTVYL PVKEGSKDPRGGIFDAVFTRGDQ KGQPREPQVYTLPPSRD QMNSLKPEDT SKLLTSRHDFKEKNLKEISDLIK ELTKNQVSLTCLVKGFY AVYYCAVLET KELTEGKALGLSHTYANVRINHV PSDIAVEWESNGQPENN RSYSFRYWGQ INLWGADFDSNGNLKAIYVTDSD YKTTPPVLDSDGSFFLY GTQVTVSSLE SNAQIGMKKYFVGVNSAGKVAIS SKLTVDKSRWQQGNVFS GGGGS AKEIKEDNIGAQVLGLFTLSTGQ CSVMHEALHNHYTQKSL (SEQID DSWNQTN(SEQIDNO: SLSPG(SEQID NO:30) 29) NO:23)

TABLE-US-00018 TABLE13 N-terminus C-terminus ID Fc C-terminusIdeS VHH His-tag VRT- DKTHTCPPCPAPEAAGA ANQEIRYSEVTPYHVTSVWTKGV QVQLQESGGG HHHHHHHH 315 PSVFLFPPKPKDTLMIS TPPAQFTQGEDVFHAPYVANQGW LVQAGGSLRL (SEQID RTPEVTCVVVDVSHEDP YDITKTFNGKDDLLCGAATAGNM SCAASGYISD NO:27) EVKFNWYVDGVEVHNAK LHWWFDQNKDQIKRYLEEHPEKQ AYYMGWYRQA TKPREEQQNSTYRVVSV KINFNGEQMFDVKEAIDTKNHQL PGKEREFVAT LTVLHQDWLNGKEYKCK DSKLFEYFKEKAFPYLSTKHLGV ITHGTNTYYA VSNKALKAPIEKTISKA FPDHVIDMFINGYRLSLTNHGPT DSVKGRFTIS KGQPREPQVYTLPPSRD PVKEGSKDPRGGIFDAVETRGDQ RDNAKNTVYL ELTKNQVSLTCLVKGFY SKLLTSRHDFKEKNLKEISDLIK QMNSLKPEDT PSDIAVEWESNGQPENN KELTEGKALGLSHTYANVRINHV AVYYCAVLET YKTTPPVLDSDGSFFLY INLWGADFDSNGNLKAIYVTDSD RSYSFRYWGQ SKLTVDKSRWQQGNVFS SNAQIGMKKYFVGVNSAGKVAIS GTQVTVSSLE CSVMHEALHNHYTQKSL AKEIKEDNIGAQVLGLFTLSTGQ GG(SEQID SLSPG(SEQID DSWNQTNGGGGS(SEQID NO:32) NO:23) NO:31) VRT- DKTHTCPPCPAPEAAGA ANQEIRYSEVTPYHVTSVWTKGV QVQLQESGGG (N/A) 316 PSVFLFPPKPKDTLMIS TPPAQFTQGEDVFHAPYVANQGW LVQAGGSLRL RTPEVTCVVVDVSHEDP YDITKTFNGKDDLLCGAATAGNM SCAASGYISD EVKFNWYVDGVEVHNAK LHWWFDQNKDQIKRYLEEHPEKQ AYYMGWYRQA TKPREEQQNSTYRVVSV KINFNGEQMFDVKEAIDTKNHQL PGKEREFVAT LTVLHQDWLNGKEYKCK DSKLFEYFKEKAFPYLSTKHLGV ITHGTNTYYA VSNKALKAPIEKTISKA FPDHVIDMFINGYRLSLINHGPT DSVKGRFTIS KGQPREPQVYTLPPSRD PVKEGSKDPRGGIFDAVFTRGDQ RDNAKNTVYL ELTKNQVSLTCLVKGFY SKLLTSRHDFKEKNLKEISDLIK QMNSLKPEDT PSDIAVEWESNGQPENN KELTEGKALGLSHTYANVRINHV AVYYCAVLET YKTTPPVLDSDGSFFLY INLWGADFDSNGNLKAIYVTDSD RSYSFRYWGQ SKLTVDKSRWQQGNVFS SNAQIGMKKYFVGVNSAGKVAIS GTQVTVSSLE CSVMHEALHNHYTQKSL AKEIKEDNIGAQVLGLFTLSTGQ (SEQID SLSPG(SEQID DSWNQTNGGGGS(SEQID NO:33) NO:23) NO:31)

[0276] In some embodiments, the polypeptides do not comprise the histidine illustrated in the table above.

[0277] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to any one amino acid sequence selected from SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336. Additional support for specific embodiments of polypeptides comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to any one amino acid sequence selected from SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336 may be found in U.S. Provisional Application No. 63/478,789, filed Jan. 6, 2023, U.S. Provisional Application No. 63/483,142, filed Feb. 3, 2023, U.S. Provisional Application No. 63/493,142, filed Mar. 31, 2023, U.S. Provisional Application No. 63/506,539, filed Jun. 6, 2023, and/or U.S. Provisional Application No. 63/600,157, filed Nov. 17, 2023, each of which is hereby incorporated by reference in its entirety.

[0278] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1311. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1312. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1313. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1314. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1315. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1316. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1317. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1318. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1319. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1320. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1321. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1322. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1323. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1324. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1325. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1326. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1327. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1328. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1329. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1334. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1335. In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to the amino acid sequence of SEQ ID NO: 1336.

[0279] In some embodiments, a polypeptide comprises the amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336, provided that the polypeptide comprises an amino acid sequence selected from any one of SEQ ID NO: 753-1019, 1290-1310 and 1333.

[0280] In some embodiments, a polypeptide comprises an amino acid sequence selected from SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1023. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1024. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1025. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1026. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1027. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1028. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1029. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1030. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1031. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1032. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1033. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1034. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1035. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1036. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1037. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1038. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1039. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1040. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1041. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1042. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1043. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1044. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1045. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1046. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1047. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1048. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1049. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1050. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1051. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1052. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1053. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1054. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1055. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1056. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1057. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1058. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1059. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1060. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1061. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1062. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1063. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1064. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1065. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1066. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1067. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1068. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1069. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1070. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1071. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1072. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1073. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1074. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1075. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1076. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1077. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1078. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1079. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1080. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1081. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1082. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1083. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1084. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1085. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1086. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1087. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1088. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1089. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1090. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1091. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1092. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1093. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1094. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1095. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1096. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1097. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1098. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1099. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1100. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1101. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1102. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1103. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1104. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1105. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1106. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1107. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1108. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1109. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1110. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1111. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1112. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1113. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1114. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1115. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1116. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1117. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1118. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1119. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1120. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1121. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1122. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1123. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1124. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1125. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1126. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1127. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1128. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1129. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1130. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1131. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1132. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1133. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1134. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1135. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1136. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1137. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1138. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1139. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1140. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1141. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1142. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1143. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1144. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1145. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1146. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1147. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1148. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1149. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1150. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1151. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1152. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1153. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1154. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1155. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1156. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1157. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1158. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1159. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1160. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1161. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1162. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1163. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1164. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1165. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1166. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1167. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1168. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1169. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1170. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1171. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1172. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1173. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1174. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1175. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1176. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1177. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1178. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1179. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1180. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1181. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1182. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1183. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1184. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1185. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1186. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1187. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1188. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1189. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1190. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1191. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1192. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1193. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1194. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1195. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1196. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1197. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1198. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1199. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1200. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1201. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1202. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1203. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1204. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1205. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1206. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1207. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1208. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1209. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1210. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1211. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1212. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1213. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1214. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1215. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1216. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1217. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1218. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1219. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1220. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1221. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1222. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1223. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1224. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1225. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1226. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1227. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1228. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1229. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1230. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1231. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1232. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1233. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1234. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1235. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1236. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1237. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1238. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1239. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1240. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1241. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1242. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1243. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1244. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1245. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1246. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1247. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1248. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1249. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1250. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1251. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1252. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1253. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1254. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1255. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1256. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1257. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1258. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1259. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1260. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1261. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1262. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1263. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1264. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1265. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1266. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1267. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1268. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1269. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1270. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1271. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1272. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1273. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1274. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1275. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1276. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1277. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1278. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1279. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1280. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1281. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1282. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1283. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1284. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1285. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1286. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1287. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1288. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1289. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1311. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1312. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1313. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1314. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1315. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1316. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1317. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1318. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1319. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1320. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1321. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1322. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1323. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1324. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1325. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1326. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1327. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1328. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1329. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1334. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1335. In some embodiments, a polypeptide comprises an amino acid sequence of SEQ ID NO: 1336.

[0281] As provided for herein, the polypeptides can also comprise a leader sequence attached to the N-terminus of the protein. For example, in some embodiments, the polypeptide has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one amino acid sequence selected from SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336, and further comprises a leader amino acid sequence. In some embodiments, the polypeptide has an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one amino acid sequence selected from SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336, and further comprises a leader amino acid sequence having an amino acid sequence of METDTLLLWVLLLWVPGSTG (SEQ ID NO: 1357), or MGWSCIILFLVATATGVHS (SEQ ID NO: 1358). In some embodiments, the leader amino acid sequence is N-terminal to the polypeptide. In some embodiments, the leader amino acid sequence facilitates expression of the polypeptide. In some embodiments, the leader amino acid sequence is processed and removed from the polypeptide during expression ex vivo or in vivo.

[0282] In some embodiments, a polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity, or is identical, to any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316.

[0283] In some embodiments, the polypeptide that is less than 100% identical to the reference sequence retains the protease activity and the Fc polypeptide is protease resistant. In some embodiments, the protease resistant Fc polypeptide comprise a Y296Q and/or a P329K mutation. In some embodiments, the protease resistant Fc polypeptide comprises a L234A, L235A, and/or G237A mutation. In some embodiments, the protease resistant Fc polypeptide comprises one, two, or each of L234A, L235A, and/or G237A mutations and one or both of Y296Q and/or a P329K mutations. In some embodiments, the protease resistant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q and P329K mutations.

[0284] In some embodiments, a polypeptide comprises an amino acid sequence of any one of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316.

[0285] In some embodiments, two (or more) polypeptides associate, either covalently or non-covalently, e.g., to form a hetero or homo-dimeric therapeutic compound. In some embodiments, the linker can comprise an Fc region and two Fc regions associate with one another. In some embodiments of a therapeutic compound comprising two linker regions, the linker regions can self-associate, e.g., as two identical Fc regions. In some embodiments of a therapeutic compound comprising two linker regions, the linker regions are not capable of, or not capable of substantial, self-association, e.g., the two Fc regions can be members of a knob and hole pair.

[0286] In some embodiments, a polypeptide can associate with another polypeptide. In some embodiments, the polypeptide associated with another polypeptide forms a dimer molecule. In some embodiments, the polypeptide comprises a first polypeptide and a second polypeptide. In some embodiments, the first polypeptide comprises a knob mutation, and the second polypeptide comprises a hole mutation. In some embodiments, the first polypeptide comprises a hole mutation, and the second polypeptide comprises a knob mutation. In some embodiments, the knob mutation is such as those provided herein. In some embodiments, the hole mutation is such as those provided herein.

[0287] In some embodiments, a dimer molecule comprises a first polypeptide and a second polypeptide. In some embodiments, a first polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336. In some embodiments, a second polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336. In some embodiments, a dimer molecule comprises a first polypeptide comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336; and a second polypeptide comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336.

[0288] In some embodiments, a dimer molecule comprises a first polypeptide and a second polypeptide. In some embodiments, a first polypeptide comprises an amino acid sequence of any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336. In some embodiments, a second polypeptide comprises an amino acid sequence of any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336. In some embodiments, a dimer molecule comprises a first polypeptide comprising an amino acid sequence of any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336; and a second polypeptide comprising an amino acid sequence of any one sequence of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336.

[0289] In some embodiments, a dimer molecule comprises a first polypeptide and a second polypeptide. In some embodiments, a first polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316. In some embodiments, a second polypeptide comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316. In some embodiments, a dimer molecule comprises a first polypeptide comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316; and a second polypeptide comprising an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99%, or 100% sequence identity to any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316.

[0290] In some embodiments, a dimer molecule comprises a first polypeptide and a second polypeptide. In some embodiments, a first polypeptide comprises an amino acid sequence of any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316. In some embodiments, a second polypeptide comprises an amino acid sequence of any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316. In some embodiments, a dimer molecule comprises a first polypeptide comprising an amino acid sequence of any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316; and a second polypeptide comprising an amino acid sequence of any one sequence of VRT-1, VRT-2, VRT-3, VRT-4, VRT-5, VRT-6, VRT-7, VRT-8, VRT-9, VRT-10, VRT-11, VRT-12, VRT-13, VRT-14, VRT-15, VRT-16, VRT-17, VRT-18, VRT-19, VRT-20, VRT-21, VRT-22, VRT-23, VRT-24, VRT-25, VRT-26, VRT-27, VRT-28, VRT-29, VRT-30, VRT-31, VRT-32, VRT-33, VRT-34, VRT-35, VRT-36, VRT-37, VRT-38, VRT-39, VRT-40, VRT-41, VRT-42, VRT-43, VRT-44, VRT-45, VRT-46, VRT-47, VRT-48, VRT-49, VRT-50, VRT-51, VRT-52, VRT-53, VRT-54, VRT-55, VRT-56, VRT-57, VRT-58, VRT-59, VRT-60, VRT-61, VRT-62, VRT-63, VRT-64, VRT-65, VRT-66, VRT-67, VRT-68, VRT-69, VRT-70, VRT-71, VRT-72, VRT-73, VRT-74, VRT-75, VRT-76, VRT-77, VRT-78, VRT-79, VRT-80, VRT-81, VRT-82, VRT-83, VRT-84, VRT-85, VRT-86, VRT-87, VRT-88, VRT-89, VRT-90, VRT-91, VRT-92, VRT-93, VRT-94, VRT-95, VRT-96, VRT-97, VRT-98, VRT-99, VRT-100, VRT-101, VRT-102, VRT-103, VRT-104, VRT-105, VRT-106, VRT-107, VRT-108, VRT-109, VRT-110, VRT-111, VRT-112, VRT-113, VRT-114, VRT-115, VRT-16, VRT-117, VRT-118, VRT-119, VRT-120, VRT-121, VRT-122, VRT-123, VRT-124, VRT-125, VRT-126, VRT-127, VRT-128, VRT-129, VRT-130, VRT-131, VRT-132, VRT-133, VRT-134, VRT-135, VRT-136, VRT-137, VRT-138, VRT-139, VRT-140, VRT-141, VRT-142, VRT-143, VRT-144, VRT-145, VRT-146, VRT-147, VRT-148, VRT-149, VRT-150, VRT-151, VRT-152, VRT-153, VRT-154, VRT-155, VRT-156, VRT-157, VRT-158, VRT-159, VRT-160, VRT-161, VRT-162, VRT-163, VRT-164, VRT-165, VRT-166, VRT-167, VRT-168, VRT-169, VRT-170, VRT-171, VRT-172, VRT-173, VRT-174, VRT-175, VRT-176, VRT-177, VRT-178, VRT-179, VRT-180, VRT-181, VRT-182, VRT-183, VRT-184, VRT-185, VRT-186, VRT-187, VRT-188, VRT-189, VRT-190, VRT-191, VRT-192, VRT-193, VRT-194, VRT-195, VRT-196, VRT-197, VRT-198, VRT-199, VRT-200, VRT-201, VRT-202, VRT-203, VRT-204, VRT-205, VRT-206, VRT-207, VRT-208, VRT-209, VRT-210, VRT-211, VRT-212, VRT-213, VRT-214, VRT-215, VRT-216, VRT-217, VRT-218, VRT-219, VRT-220, VRT-221, VRT-222, VRT-223, VRT-224, VRT-225, VRT-226, VRT-227, VRT-228, VRT-229, VRT-230, VRT-231, VRT-232, VRT-233, VRT-234, VRT-235, VRT-236, VRT-237, VRT-238, VRT-239, VRT-240, VRT-241, VRT-242, VRT-243, VRT-244, VRT-245, VRT-246, VRT-247, VRT-248, VRT-249, VRT-250, VRT-251, VRT-252, VRT-253, VRT-254, VRT-255, VRT-256, VRT-257, VRT-258, VRT-259, VRT-260, VRT-261, VRT-262, VRT-263, VRT-264, VRT-265, VRT-266, VRT-267, VRT-268, VRT-269, VRT-270, VRT-271, VRT-272, VRT-273, VRT-274, VRT-275, VRT-276, VRT-277, VRT-278, VRT-279, VRT-280, VRT-281, VRT-282, VRT-283, VRT-284, VRT-285, VRT-286, VRT-287, VRT-289, VRT-290, VRT-291, VRT-292, VRT-293, VRT-294, VRT-295, VRT-296, VRT-297, VRT-298, VRT-299, VRT-300, VRT-301, VRT-302, VRT-303, VRT-304, VRT-305, VRT-306, VRT-307, VRT-308, VRT-309, VRT-310, VRT-311, VRT-312, VRT-313, VRT-314, VRT-315, or VRT-316.

[0291] In some embodiments, the dimer is a homodimer molecule. In some embodiments, the dimer is a heterodimer molecule.

[0292] As used herein, the term non-covalently conjugated can mean that a polypeptide is tethered to another polypeptide through a linker. In some embodiments, the linker is a peptide linker. Non-limiting examples of peptide linkers that can be used are known in the art and are provide for herein.

[0293] As discussed herein the different domains, molecules, or polypeptide can be linked together with a linker domain or region. Any linker region described herein can be used as a linker. Linkers can be for example, glycine/serine linkers. In some embodiments, the linker can comprise one or more repeats of GGGGS (SEQ ID NO: 1337). In some embodiments, the linker comprises 1, 2, 3, 4, or 5 repeats. In some embodiments, the linker comprises the sequence of GGGGSGGGGS (SEQ ID NO: 1338). In some embodiments, the linker comprises the sequence of GGGGSGGGGSGGGGS (SEQ ID NO: 1339). In some embodiments, the linker comprises the sequence of GGGGSGGGGSGGGGSG (SEQ ID NO: 1020). In some embodiments, the linker comprises the sequence of GGGGSGGGGSGGGGSGGGGSG (SEQ ID NO: 1021). In some embodiments, the linker comprises the sequence of GGGGSGGGGSG (SEQ ID NO: 1022). In some embodiments, the linker comprises: GGGGS (SEQ ID NO: 1337), (GGGGS).sub.3 (SEQ ID NO: 1339), (GGGGS). (n=1, 2, 3, 4) (SEQ ID NO: 1337, SEQ ID NO: 1338, SEQ ID NO: 1339, SEQ ID NO: 1340, respectively), (Gly).sub.8 (SEQ ID NO: 1341), (Gly).sub.6 (SEQ ID NO: 1342), (EAAAK).sub.3 (SEQ ID NO: 1343), (EAAK). (n=1-3) (SEQ ID NO: 1344, SEQ ID NO: 1345, SEQ ID NO: 1346, respectively), A(EAAAK).sub.4ALEA(EAAAK)4A (SEQ ID NO: 1347), or AEAAAKEAAAKA (SEQ ID NO: 1348). These linkers can be used in any of the compounds or compositions provided herein.

[0294] Antibody molecule, as that term is used herein, refers to a polypeptide, e.g., an immunoglobulin chain or fragment thereof, comprising at least one functional immunoglobulin variable domain sequence. An antibody molecule encompasses antibodies (e.g., full-length antibodies) and antibody fragments. In some embodiments, an antibody molecule comprises an antigen binding or functional fragment of a full length antibody, or a full length immunoglobulin chain. For example, a full-length antibody is an immunoglobulin (Ig) molecule (e.g., an IgG antibody) that is naturally occurring or formed by normal immunoglobulin gene fragment recombinatorial processes). In embodiments, an antibody molecule refers to an immunologically active, antigen-binding portion of an immunoglobulin molecule, such as an antibody fragment. An antibody fragment, e.g., functional fragment, comprises a portion of an antibody, e.g., Fab, Fab, F(ab)2, F(ab)2, variable fragment (Fv), domain antibody (dAb), or single chain variable fragment (scFv). A functional antibody fragment binds to the same antigen as that recognized by the intact (e.g., full-length) antibody. The terms antibody fragment or functional fragment also include isolated fragments consisting of the variable regions, such as the Fv fragments consisting of the variable regions of the heavy and light chains or recombinant single chain polypeptide molecules in which light and heavy variable regions are connected by a peptide linker (scFv proteins). In some embodiments, an antibody fragment does not include portions of antibodies without antigen binding activity, such as Fc fragments or single amino acid residues. Exemplary antibody molecules include full length antibodies and antibody fragments, e.g., dAb (domain antibody), single chain, Fab, Fab, and F(ab)2 fragments, and single chain variable fragments (scFvs).

[0295] The term antibody molecule also encompasses whole or antigen binding fragments of domain, or single domain, antibodies, which can also be referred to as sdAb or VHH. Domain antibodies comprise either V.sub.H or V.sub.L that can act as stand-alone, antibody fragments. Additionally, domain antibodies include heavy-chain-only antibodies (HCAbs). Domain antibodies also include a CH2 domain of an IgG as the base scaffold into which CDR loops are grafted. It can also be generally defined as a polypeptide or protein comprising an amino acid sequence that is comprised of four framework regions interrupted by three complementarity determining regions. This is represented as FP1-CDP1-FR2-CDR2-FN1-CDN1-FR4. sdAbs can be produced in camelids such as llamas, but can also be synthetically generated using techniques that are well known in the art. The numbering of the amino acid residues of a sdAb or polypeptide is according to the general numbering for VH domains given by Kabat et al. (Sequence of proteins of immunological interest, US Public Health Services, NIH Bethesda, MD, Publication No. 91, which is hereby incorporated by reference). According to this numbering, FP1 of a sdAb comprises the amino acid residues at positions 1-30, CDP1 of a sdAb comprises the amino acid residues at positions 31-36, FR2 of a sdAb comprises the amino acids at positions 36-49, CDR2 of a sdAb comprises the amino acid residues at positions 50-65, FN1 of a sdAb comprises the amino acid residues at positions 66-94, CDN1 of a sdAb comprises the amino acid residues at positions 95-102, and FR4 of a sdAb comprises the amino acid residues at positions 103-113. Domain antibodies are also described in WO2004041862 and WO2016065323, each of which is hereby incorporated by reference. The domain antibodies can be a targeting moiety as described herein.

[0296] Antibody molecules can be monospecific (e.g., monovalent or bivalent), bispecific (e.g., bivalent, trivalent, tetravalent, pentavalent, or hexavalent), trispecific (e.g., trivalent, tetravalent, pentavalent, hexavalent), or with higher orders of specificity (e.g, tetraspecific) and/or higher orders of valency beyond hexavalency. An antibody molecule can comprise a functional fragment of a light chain variable region and a functional fragment of a heavy chain variable region, or heavy and light chains may be fused together into a single polypeptide. Effector, as that term is used herein, refers to an entity, e.g., a cell or molecule, e.g., a soluble or cell surface molecule, which mediates an immune response. In some embodiments, the effector is an antibody. In some embodiments, the effectors binding domains as provided for herein, refers to a polypeptide (e.g.) that has sufficient binding specificity that it can bind the effector with sufficient specificity that it can serve as an effector binding/modulating molecule. In some embodiments, it binds to effector with at least 10, 20, 30, 40, 50, 60, 70, 80, 90, or 95% of the affinity of the naturally occurring counter-ligand. In some embodiments, it has at least 60, 70, 80, 90, 95, 99, or 100% sequence identity, or substantial sequence identity, with a naturally occurring counter-ligand for the effector.

[0297] Elevated risk, as used herein, refers to the risk of a disorder in a subject, wherein the subject has one or more of a medical history of the disorder or a symptom of the disorder, a biomarker associated with the disorder or a symptom of the disorder, or a family history of the disorder or a symptom of the disorder.

[0298] The domains can have similarity to those as provided for herein or those that are incorporated by reference. Sequence identity, percentage identity, and related terms, as those terms are used herein, refer to the relatedness of two sequences, e.g., two nucleic acid sequences or two amino acid or polypeptide sequences. In the context of an amino acid sequence, the term substantially identical is used herein to refer to a first amino acid that contains a sufficient or minimum number of amino acid residues that are i) identical to, or ii) conservative substitutions of aligned amino acid residues in a second amino acid sequence such that the first and second amino acid sequences can have a common structural domain and/or common functional activity. For example, amino acid sequences that contain a common structural domain having at least about 85%, 90%. 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to a reference sequence, e.g., an amino acid sequence provided herein.

[0299] In the context of nucleotide sequence, such as those encoding for the domains, the term substantially identical is used herein to refer to a first nucleic acid sequence that contains a sufficient or minimum number of nucleotides that are identical to aligned nucleotides in a second nucleic acid sequence such that the first and second nucleotide sequences encode a polypeptide having common functional activity, or encode a common structural polypeptide domain or a common functional polypeptide activity. For example, nucleotide sequences having at least about 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to a reference sequence, e.g., an amino acid sequence provided herein.

[0300] The term functional variant refers to polypeptides that have a substantially identical amino acid sequence to the naturally-occurring sequence, or are encoded by a substantially identical nucleotide sequence, and are capable of having one or more activities of the naturally-occurring sequence. For example, a Fc variant can have the amino acid sequence of a Fc polypeptide but comprise a mutation that prevents or disrupts cleavage by a protease.

[0301] Calculations of homology or sequence identity between sequences (the terms are used interchangeably herein) can be performed as follows.

[0302] To determine the percent identity of two amino acid sequences, or of two nucleic acid sequences, the amino acid sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, the length of a reference sequence aligned for comparison purposes is at least 30%, preferably at least 40%, more preferably at least 50%, 60%, and even more preferably at least 70%, 80%, 90%, 100% of the length of the reference sequence. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein amino acid or nucleic acid identity is equivalent to amino acid or nucleic acid homology).

[0303] The percent identity between the two sequences is a function of the number of identical positions shared by the amino acid sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.

[0304] The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch ((1970) J. Mol. Biol. 48:444-453) algorithm which has been incorporated into the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blossum 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package (available at http://www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. A particularly preferred set of parameters (and the one that should be used unless otherwise specified) are a Blossum 62 scoring matrix with a gap penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.

[0305] The percent identity between two amino acid or nucleotide sequences can be determined using the algorithm of E. Meyers and W. Miller ((1989) CABIOS, 4:11-17) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4.

[0306] The nucleic acid and protein sequences described herein can be used as a query sequence to perform a search against public databases to, for example, identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990) J. Mol. Biol. 215:403-10. BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to for example any a nucleic acid sequence provided herein. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to protein molecules provided herein. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997) Nucleic Acids Res. 25:3389-3402. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. See http://www.ncbi.nlm.nih.gov.

[0307] As used herein, the term hybridizes under low stringency, medium stringency, high stringency, or very high stringency conditions describes conditions for hybridization and washing. Guidance for performing hybridization reactions can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6, which is incorporated by reference. Aqueous and nonaqueous methods are described in that reference and either can be used. Specific hybridization conditions referred to herein are as follows: 1) low stringency hybridization conditions in 6? sodium chloride/sodium citrate (SSC) at about 45? C., followed by two washes in 0.2?SSC, 0.1% SDS at least at 50? C. (the temperature of the washes can be increased to 55? C. for low stringency conditions); 2) medium stringency hybridization conditions in 6?SSC at about 45? C., followed by one or more washes in 0.2?SSC, 0.1% SDS at 60? C.; 3) high stringency hybridization conditions in 6?SSC at about 45? C., followed by one or more washes in 0.2?SSC, 0.1% SDS at 65? C.; and preferably 4) very high stringency hybridization conditions are 0.5M sodium phosphate, 7% SDS at 65? C., followed by one or more washes at 0.2?SSC, 1% SDS at 65? C. Very high stringency conditions (4) are the preferred conditions and the ones that should be used unless otherwise specified.

[0308] It is understood that the molecules of the present embodiments may have additional conservative or non-essential amino acid substitutions, which do not have a substantial effect on their functions.

[0309] The term amino acid is intended to embrace all molecules, whether natural or synthetic, which include both an amino functionality and an acid functionality and capable of being included in a polymer of naturally-occurring amino acids. Exemplary amino acids include naturally-occurring amino acids; analogs, derivatives and congeners thereof; amino acid analogs having variant side chains; and all stereoisomers of any of any of the foregoing. As used herein the term amino acid includes both the D- or L-optical isomers and peptidomimetics.

[0310] A conservative amino acid substitution is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine).

[0311] The molecules and polypeptides provided for herein can be used to treat diseases and conditions mediated by IgG. Thus, embodiments are provided for methods of treating an IgG mediated disease or disorder in a subject. In some embodiments, the IgG mediated disease or disorder is an autoimmune disease or disorder. In some embodiments, the methods comprise administering to the subject a polypeptide, molecule, compound, or compositions as provided for herein. In some embodiments, the subject has or is at risk of having an IgG mediated disease or disorder. In some embodiments, the subject has or is at risk of having an autoimmune disease or disorder.

[0312] Antibody-mediated rejection (AMR) causes severe and rapid dysfunction and loss of allografts. Without wishing to be bound to a particular theory, the most common mechanism underlying AMR is an anamnestic response that originates from previous antigenic exposure. These donor specific antibody (DSA) responses are usually robust and result in the rapid production of high levels of DSA and acute allograft dysfunction. The mechanism of injury in AMR involves antigens that initiate the production of DSAs resulting in antigen-antibody interactions, complement activation and inflammation, and the resultant donor tissue damage. The impact of AMR on graft survival is dramatic and continues long after the initial inflammatory condition has resolved as was recently demonstrated in a study by LeFaucheur and Glotz. In this single center study of a large cohort of sensitized recipients, the investigators compared allograft survival for recipients successfully treated for AMR versus those that never experienced AMR. In some embodiments, the molecules and polypeptides provided for herein can be used to treat AMR.

[0313] In some embodiments, methods of treating a disease or disorder in a subject are provided. In some embodiments, the disease or disorder is an Ig mediated disease or disorder. In some embodiments, the disease or disorder is an autoimmune disease or disorder.

[0314] In some embodiments, methods of decreasing circulating immunoglobulins in a subject are provided. In some embodiments, the circulating immunoglobulins are selected from IgG (such as IgG1, IgG2, IgG3, IgG4), IgA, IgM, IgE, or IgD. In some embodiments, methods of decreasing circulating IgG immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgG1 immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgG2 immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgG3 immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgG4 immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgA immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgM immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgE immunoglobulins are provided. In some embodiments, methods of decreasing circulating IgD immunoglobulins are provided. In some embodiments, methods of decreasing circulating immunoglobulins in a subject are provided, wherein the subject is a subject with an autoimmune disease or disorder.

[0315] In some embodiments, a method of reducing immunoglobulins is provided. In some embodiments, a method of reducing immunoglobulins, such as IgG, in a subject, is provided. In some embodiments, the method of reducing immunoglobulins, such as IgG, in a subject, comprises administering to the subject any one of the polypeptides or compositions provided for herein. In some embodiments, the method of reducing immunoglobulins, such as IgG, in a subject, comprises administering to the subject the polypeptide comprising the amino acid sequence of any one of SEQ ID NO: 55-1019, 1023-1329, and 1333-1336 or the composition thereof. In some embodiments, the reduction of immunoglobulins may be about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, about 95%, or about 100% reduction. In some embodiments, the reduction of immunoglobulins may be at least 5%, at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, or at least 95% reduction. In some embodiments, the reduction of immunoglobulins may be a 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100% reduction.

[0316] In some embodiments, a method of treating a disease or disorder in a subject is provided. In some embodiments, the method of treating a disease or disorder in a subject, comprises administering to the subject any one of the polypeptides or compositions provided for herein. In some embodiments, the method of treating a disease or disorder in a subject comprises administering to the subject the polypeptide comprising the amino acid sequence of any one of SEQ ID NO: 55-1019, 1023-1329, and 1333-1336 or the composition thereof.

[0317] In some embodiments, a method of treating a transplant subject is provided. In some embodiments, the method of treating a transplant subject comprises administering to the subject any one of the polypeptides or compositions provided for herein. In some embodiments, the method of treating a transplant subject comprises administering to the subject the polypeptide comprising the amino acid sequence of any one of SEQ ID NO: 55-1019, 1023-1329, and 1333-1336 or the composition thereof.

[0318] In some embodiments, a method of improving a gene-therapy in subject is provided. In some embodiments, the method of improving a gene-therapy in subject comprises administering to the subject any one of the polypeptides or compositions provided for herein. In some embodiments, the method of improving a gene-therapy in subject comprises administering to the subject the polypeptide comprising the amino acid sequence of any one of SEQ ID NO: 55-1019, 1023-1329, and 1333-1336 or the composition thereof.

[0319] In some embodiments, a method of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder is provided. In some embodiments, the method of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder comprises administering to the subject any one of the polypeptides or compositions provided for herein. In some embodiments, the method of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder comprises administering to the subject the polypeptide comprising the amino acid sequence of any one of SEQ ID NO: 55-1019, 1023-1329, and 1333-1336 or the composition thereof.

[0320] In some embodiments, a method of cleaving B cell receptor in a subject is provided. In some embodiments, the method of cleaving B cell receptor in a subject comprises administering to the subject any one of the polypeptides or compositions provided for herein. In some embodiments, the method of cleaving B cell receptor in a subject comprises administering to the subject the polypeptide comprising the amino acid sequence of any one of SEQ ID NO: 55-1019, 1023-1329, and 1333-1336 or the composition thereof.

[0321] Non-limiting examples of diseases and disorders, such as autoimmune diseases or disorders, that can be treated with the molecules and polypeptides described herein include, but are not limited to, Addison's disease, Anti-GBM glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated vasculitides, ANCA associated vasculitis, granulomatous polyangiitis (Wegener granulomatosis), eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), microscopic polyangiitis, anti-NMDAR encephalitis, anti-phospholipid antibody syndrome (APS) and catastrophic APS, autoimmune bullous skin diseases, pemphigus, pemphigus foliaceus (PF), fogo selvage (FS), pemphigus vulgaris (PV), autoimmune hemolytic anemia (AIHA), autoimmune hepatitis (AIH), autoimmune neutropenia (AIN), bullous pemphigoid (BP), Celiac's disease, chronic urticaria, complete congenital heart block (CCHB), diabetes type 1A (T1DM), epidermolysis bullosa acquisita (EBA), essential mixed cryoglobulinemia, Goodpasture's syndrome, anti-glomerular basement membrane disease, Graves' disease, Goitre, hyperthyroidism, infiltrative exophthalmos, infiltrative dermopathy, Guillain-Barre syndrome (GBS), acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), hemophilia, acquired FVII deficiency, idiopathic thrombocytopenic purpura (ITP), Lambert-Eaton myasthenic syndrome (LEMS), mixed connective tissue disease (MCTD), multiple myeloma, myasthenia gravis, myasthenic crisis, myocarditis, dilated cardiomyopathy (DCM), congestive cardiomyopathy, neuromyelitis optica (NMO), primary biliary cirrhosis (PBC), primary progressive multiple sclerosis (PPMS), relapsing-rheumatic multiple sclerosis, acute exacerbation of multiple sclerosis, rheumatic heart disease (RHD), rheumatoid arthritis (RA), serum-sickness, immune complex hypersensitivity (type III), Sj?gren's syndrome (SS), lupus nephritis, systemic lupus erythematosus (SLE), cutaneous lupus (CLE), transplant rejection, thrombotic thrombocytopenic purpura (TTP), idiopathic inflammatory myopathies, polymyositis, dermatomyositis, inclusion body myositis, uveitis, scleritis, ankylosing spondylitis, axial spondyloarthritis, reactive arthritis, psoriatic arthritis, IBD-associated arthritis, antiphospholipid syndrome, systemic sclerosis, giant cell arteritis, polymyalgia rheumatic, Takayasu's arteritis, anti-neutrophil cytoplasmic antibody associated vasculitis, Henoch-Schonlein purpura, polyarteritis nodosa, Cogan's syndrome, Buerger's disease, Susan's disease, immune complex vasculitis, primary angiitis of the central nervous system (CNS), Behcet's disease, relapsing polychondritis, juvenile idiopathic arthritis, juvenile dermatomyositis, autoimmune brain disease, sarcoidosis, neurosarcoidosis, IgG4-related diseases, autoimmune complications of immune checkpoint inhibitors (IRAEs), adult onset Still's disease, warm antibody hemolytic anemia (wAIHA), immune thrombocytopenia, immune thrombotic thrombocytopenia, thrombic thrombocytopenia, pernicious anemia, aplastic anemia, Evan's syndrome, autoimmune neutropenia, acquired von Willibrand syndrome, recurring fetal loss, Rh mismatch, ulcerative colitis, autoimmune hepatitis, autoimmune pancreatitis, eosinophilic esophagitis/gastritis, primary sclerosing cholangitis, primary biliary sclerosis, glomerulonephritis, glomerular basement membrane disease, scleritis/episcleritis, uveitis, conjunctivitis, keratitis, type I diabetes mellitus, Hashimoto's thyroiditis, polyglandular autoimmune endocrine syndromes, atopic dermatitis, dermatitis herpetiformis, pemphigus foliaceus, fogo selvagem, cutaneous lupus erythematosus, linear IgA disease, Lichen planus, transplantation, antibody-mediated rejection, alloantibody hypersensitization, xenoantibody mediated rejection, solid organ rejection, graft vs. host disease (GVHD), multiple sclerosis, neuromyelitis optica, amyotrophic lateral sclerosis, Parkinson's disease, autoimmune encephalitis, CNS vasculitis, chronic idiopathic demyletinating polyneuropathy, transverse myelitis, optic neuritis, anti-myelin oligodendrocyte glycoprotein (MOG) disease, chronic meningitis, rheumatic heart disease, infectious disease, vaccination, antibody dependent enhancement, antibody to therapeutic biologic agents (cytokines, monoclonal antibodies, enzymes, coagulation factors), allergic asthma, eosinophilic pneumonia, nonspecific interstitial pneumonia, rheumatoid arthritis-associated interstitial lung disease (RA-ILD), sarcoidosis, hypersensitive pneumonitis, allergic bronchopulmonary mycosis, chronic rhinosinusitis with nasal polyps, and the like.

[0322] In some embodiments, methods of treating a transplant subject are provided. In some embodiments, methods of improving a gene-therapy in a subject are provided. In some embodiments, methods of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder are provided.

[0323] In some embodiments, methods comprise administering a therapeutically effective amount of any one of the polypeptides provided herein, or the pharmaceutical composition comprising any one polypeptide provided herein, thereby treating the subject.

[0324] In some embodiments, the condition or disease to be treated is a neoplastic disorder, such as a cancer. In some embodiments, the cancer is a solid or liquid tumor. In some embodiments, the liquid or solid tumor include, but are not limited to, hematopoietic cancer, lymphoid cancer, skin cancer, head and neck cancer, genitourinary cancer, blood cancer, lung cancer, breast cancer, brain cancer, esophageal cancer, colorectal cancer, pancreatic cancer, and any combination thereof.

Pharmaceutical Compositions and Kits

[0325] In some embodiments, the present embodiments provide compositions, e.g., pharmaceutically acceptable compositions, which include a therapeutic compound described herein, formulated together with a pharmaceutically acceptable carrier. As used herein, pharmaceutically acceptable carrier includes any and all solvents, dispersion media, isotonic and absorption delaying agents, and the like that are physiologically compatible.

The carrier can be suitable for intravenous, intramuscular, subcutaneous, parenteral, rectal, local, ophthalmic, topical, spinal or epidermal administration (e.g. by injection or infusion). As used herein, the term carrier means a diluent, adjuvant, or excipient with which a compound is administered. In some embodiments, pharmaceutical carriers can also be liquids, such as water and oils, including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. The pharmaceutical carriers can also be saline, gum acacia, gelatin, starch paste, talc, keratin, colloidal silica, urea, and the like. In addition, auxiliary, stabilizing, thickening, lubricating and coloring agents can be used. The carriers can be used in pharmaceutical compositions comprising the therapeutic compounds provided for herein.

[0326] The compositions and compounds of the embodiments provided for herein may be in a variety of forms. These include, for example, liquid, semi-solid and solid dosage forms, such as liquid solutions (e.g., injectable and infusible solutions), dispersions or suspensions, liposomes and suppositories. The preferred form depends on the intended mode of administration and therapeutic application. Typical compositions are in the form of injectable or infusible solutions. In some embodiments, the mode of administration is parenteral (e.g., intravenous, subcutaneous, intraperitoneal, intramuscular). In some embodiments, the therapeutic molecule is administered by intravenous infusion or injection. In another embodiment, the therapeutic molecule is administered by intramuscular or subcutaneous injection. In another embodiment, the therapeutic molecule is administered locally, e.g., by injection, or topical application, to a target site.

[0327] The phrases parenteral administration and administered parenterally as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intraarterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal, epidural and intrasternal injection and infusion.

[0328] The compositions typically should be sterile and stable under the conditions of manufacture and storage. The composition can be formulated as a solution, microemulsion, dispersion, liposome, or other ordered structure suitable to high therapeutic molecule concentration. Sterile injectable solutions can be prepared by incorporating the active compound (i.e., therapeutic molecule) in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle that contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum drying and freeze-drying that yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof. The proper fluidity of a solution can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prolonged absorption of injectable compositions can be brought about by including in the composition an agent that delays absorption, for example, monostearate salts and gelatin.

[0329] As will be appreciated by the skilled artisan, the route and/or mode of administration will vary depending upon the desired results. In certain embodiments, the active compound may be prepared with a carrier that will protect the compound against rapid release, such as a controlled release formulation, including implants, transdermal patches, and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Many methods for the preparation of such formulations are patented or generally known to those skilled in the art. See, e.g., Sustained and Controlled Release Drug Delivery Systems, J. R. Robinson, ed., Marcel Dekker, Inc., New York, 1978.

[0330] In certain embodiments, a therapeutic compound can be orally administered, for example, with an inert diluent or an assimilable edible carrier. The compound (and other ingredients, if desired) may also be enclosed in a hard or soft shell gelatin capsule, compressed into tablets, or incorporated directly into the subject's diet. For oral therapeutic administration, the compounds may be incorporated with excipients and used in the form of ingestible tablets, buccal tablets, troches, capsules, elixirs, suspensions, syrups, wafers, and the like. To administer a compound by other than parenteral administration, it may be necessary to coat the compound with, or co-administer the compound with, a material to prevent its inactivation. Therapeutic compositions can also be administered with medical devices known in the art.

[0331] Dosage regimens are adjusted to provide the optimum desired response (e.g., a therapeutic response). For example, a single bolus may be administered, several divided doses may be administered over time or the dose may be proportionally reduced or increased as indicated by the exigencies of the therapeutic situation. It is especially advantageous to formulate parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subjects to be treated; each unit contains a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier. The specification for the dosage unit forms are dictated by and directly dependent on (a) the unique characteristics of the active compound and the particular therapeutic effect to be achieved, and (b) the limitations inherent in the art of compounding such an active compound for the treatment of sensitivity in individuals.

[0332] An exemplary, non-limiting range for a therapeutically or prophylactically effective amount of a therapeutic compound is 0.1-30 mg/kg, more preferably 1-25 mg/kg. Dosages and therapeutic regimens of the therapeutic compound can be determined by a skilled artisan. In certain embodiments, the therapeutic compound is administered by injection (e.g., subcutaneously or intravenously) at a dose of about 1 to 40 mg/kg, e.g., 1 to 30 mg/kg, e.g., about 5 to 25 mg/kg, about 10 to 20 mg/kg, about 1 to 5 mg/kg, 1 to 10 mg/kg, 5 to 15 mg/kg, 10 to 20 mg/kg, 15 to 25 mg/kg, or about 3 mg/kg. The dosing schedule can vary from e.g., once a week to once every 2, 3, or 4 weeks. In one embodiment, the therapeutic compound is administered at a dose from about 10 to 20 mg/kg every other week. The therapeutic compound can be administered by intravenous infusion at a rate of more than 20 mg/min, e.g., 20-40 mg/min, and typically greater than or equal to 40 mg/min to reach a dose of about 35 to 440 mg/m.sup.2, typically about 70 to 310 mg/m.sup.2, and more typically, about 110 to 130 mg/m.sup.2. In embodiments, the infusion rate of about 110 to 130 mg/m.sup.2 achieves a level of about 3 mg/kg. In other embodiments, the therapeutic compound can be administered by intravenous infusion at a rate of less than 10 mg/min, e.g., less than or equal to 5 mg/min to reach a dose of about 1 to 100 mg/m.sup.2, e.g., about 5 to 50 mg/m.sup.2, about 7 to 25 mg/m.sup.2, or, about 10 mg/m.sup.2. In some embodiments, the therapeutic compound is infused over a period of about 30 min. It is to be noted that dosage values may vary with the type and severity of the condition to be alleviated. It is to be further understood that for any particular subject, specific dosage regimens should be adjusted over time according to the individual need and the professional judgment of the person administering or supervising the administration of the compositions, and that dosage ranges set forth herein are exemplary only and are not intended to limit the scope or practice of the claimed composition.

[0333] The pharmaceutical compositions may include a therapeutically effective amount or a prophylactically effective amount of a therapeutic molecule. A therapeutically effective amount refers to an amount effective, at dosages and for periods of time necessary, to achieve the desired therapeutic result. A therapeutically effective amount of a therapeutic molecule may vary according to factors such as the disease state, age, sex, and weight of the individual, and the ability of the therapeutic compound to elicit a desired response in the individual. A therapeutically effective amount is also one in which any toxic or detrimental effects of a therapeutic molecule is outweighed by the therapeutically beneficial effects. A therapeutically effective dosage preferably inhibits a measurable parameter, e.g., immune attack at least about 20%, more preferably by at least about 40%, even more preferably by at least about 60%, and still more preferably by at least about 80% relative to untreated subjects. The ability of a compound to inhibit a measurable parameter, e.g., immune attack, can be evaluated in an animal model system predictive of efficacy in transplant rejection or autoimmune disorders. Alternatively, this property of a composition can be evaluated by examining the ability of the compound to inhibit, such inhibition in vitro by assays known to the skilled practitioner.

[0334] A prophylactically effective amount refers to an amount effective, at dosages and for periods of time necessary, to achieve the desired prophylactic result. Typically, since a prophylactic dose is used in subjects prior to or at an earlier stage of disease, the prophylactically effective amount will be less than the therapeutically effective amount.

[0335] B-cell receptors (BCRs) are crucial elements of the adaptive immune system and are expressed on the surface of B cells (Xie, W., Wucherpfennig, K. & Patel, D. J. A structural platform for B cell receptor signaling. Cell Res 33, 95-96 (2023). https://doi.org/10.1038/s41422-022-00724-9). These receptors are responsible for recognizing and binding antigens. Without wishing to be bound by a particular theory, B-cell receptors are composed of two heavy chains and two light chains forming an antigen-binding fragment (Fab). This Fab region is responsible for recognizing and binding specific antigens. Attached to the Fab fragment is the constant region, composed of the remainder of the two heavy chains. The constant region spans the B cell membrane and includes a short intracellular segment that signals the B cell when an antigen is bound. When a BCR binds to an antigen, the B cell engulfs the antigen and presents fragments of it on the cell surface using a molecule called major histocompatibility complex II (MHC II). This action attracts a type of T cell called a helper T cell, which binds to the antigen fragment and the MHC II molecule. The binding of the helper T cell releases substances that stimulate the B cell to divide and differentiate into memory B cells and plasma cells. The plasma cells produce and secrete large amounts of the BCR in a form called an antibody that can travel throughout the body in the blood, binding to antigens and marking them for destruction.

[0336] The BCR can be cleaved to yield a soluble form. The cleavage product of a BCR is an antibody. In some embodiments, the cleavage product of a BCR which is an antibody, marks antigens for destruction by phagocytes, natural killer cells, or the complement system. Thus, in some embodiments, methods of cleaving a B cell receptor are provided. In some embodiments, the method comprises administering a therapeutically effective amount of any one polypeptide provided herein, or the pharmaceutical composition thereof, to cleave the B cell receptor. In some embodiments, the polypeptide is administered to a cell, a tissue, an animal, or a subject. In some embodiments, the cell, the tissue, the animal, or the subject is any cell, tissue, animal, or subject.

[0337] In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, may be administered to a subject. In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, may be administered to a subject in need thereof. In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, may be administered more than once (e.g., two times, three times, four times, five times, or more). In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, may be administered at least once, at least twice, at least three time, at least four times, or more. In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, may be administered to a subject without inducing an immune response from the subject. In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, does not induce an immune response from a subject after administration to the subject. In some embodiments, the polypeptide having IgG protease activity, such as those provided herein, may be administered to a subject more than once without inducing an immune response from the subject.

[0338] Also within the scope of the embodiments is a kit comprising a therapeutic compound described herein. The kit can include one or more other elements including: instructions for use; other reagents, e.g., a label, a therapeutic agent, or an agent useful for chelating, or otherwise coupling, a therapeutic molecule to a label or other therapeutic agent, or a radioprotective composition; devices or other materials for preparing the a therapeutic molecule for administration; pharmaceutically acceptable carriers; and devices or other materials for administration to a subject.

[0339] In some embodiments, a pharmaceutical composition comprising any one of the polypeptides provided herein is provided. In some embodiments, the composition comprises a dimer comprising a first polypeptide comprising any one of the polypeptides provided herein and a second polypeptide comprising any one of the polypeptides provided herein, wherein the first polypeptide and the second polypeptide are the same. In some embodiments, the composition comprises a dimer comprising a first polypeptide comprising any one of the polypeptides provided herein linked to a first protease resistant Fc domain, and a second polypeptide comprising any one of the polypeptides provided herein linked to a second protease resistant Fc domain, wherein the first polypeptide and the second polypeptide are the same. In some embodiments, the first protease resistant Fc domain and the second protease resistant Fc domain comprise the same amino acid sequence. In some embodiments, the first protease resistant Fc domain and the second protease resistant Fc domain comprise different amino acid sequences, provided that the first and second Fc domains can form a dimer. In some embodiments, the first and second protease resistant Fc domains comprise, independently, the amino acid sequence of any one of SEQ ID NOs: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49. In some embodiments, the protease resistant Fc domain comprises the amino acid sequence of SEQ ID NO: 23.

[0340] A protease or a polypeptide provided for herein may be produced by any suitable means. For example, the protease or the polypeptide may be synthesized directly using standard techniques known in the art.

[0341] As used herein, the terms nucleic acid molecule and polynucleotide may be used interchangeably and refer to a polymeric form of nucleotides of any length, either deoxyribonucleotides or ribonucleotides, or analogs thereof. Non-limiting examples of polynucleotides include a gene, a gene fragment, messenger RNA (mRNA), cDNA, recombinant polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, nucleic acid probes, and primers. A polynucleotide of the disclosure may be provided in isolated or substantially isolated form. By substantially isolated, it is meant that there may be substantial, but not total, isolation of the polypeptide from any surrounding medium. The polynucleotides may be mixed with carriers or diluents which will not interfere with their intended use and still be regarded as substantially isolated. A nucleic acid sequence which encodes a selected polypeptide is a nucleic acid molecule which is transcribed (in the case of DNA) and translated (in the case of mRNA) into a polypeptide in vivo when placed under the control of appropriate regulatory sequences. The boundaries of the coding sequence are determined by a start codon at the 5 (N-) terminus and a translation stop codon at the 3 (C-) terminus. For the purposes of the disclosure, such nucleic acid sequences can include, but are not limited to, cDNA from viral, prokaryotic or eukaryotic mRNA, genomic sequences from viral or prokaryotic DNA or RNA, and even synthetic DNA sequences. A transcription termination sequence may be located 3 to the coding sequence.

[0342] Polynucleotides encoding protease or polypeptides provided for herein may be synthesized according to methods well known in the art, as described by way of example in Sambrook et al (1989, Molecular Cloninga laboratory manual; Cold Spring Harbor Press). The nucleic acid molecules of the present disclosure may be provided in the form of an expression cassette which includes control sequences operably linked to the inserted sequence, thus allowing for expression of the polypeptide of the disclosure in vivo. These expression cassettes, in turn, are typically provided within vectors (e.g., plasmids or recombinant viral vectors). Such an expression cassette may be administered directly to a host subject.

[0343] In some embodiments, the protease or the polypeptide provided for herein may be produced by transforming a cell, typically a bacterial cell, with a nucleic acid molecule or vector which encodes said protease or polypeptide. In some embodiments, a vector comprising a polynucleotide encoding a protease or a polypeptide provided for herein may be administered to a host subject. In some embodiments, the polynucleotide is prepared and/or administered using a vector. A suitable vector may be any vector which is capable of carrying a sufficient amount of genetic information, and allowing expression of a protease or a polypeptide of the disclosure. In some embodiments, nucleic acid molecules or a polynucleotide is provided that encodes a protease or a polypeptide as provided for herein. In some embodiments, the polynucleotide is DNA. In some embodiments, the polynucleotide is RNA, such as mRNA.

[0344] The present disclosure thus includes expression vectors that comprise such polynucleotide sequences. Such expression vectors are routinely constructed in the art of molecular biology and may for example involve the use of plasmid DNA and appropriate initiators, promoters, enhancers and other elements, such as for example polyadenylation signals which may be necessary, and which are positioned in the correct orientation, in order to allow for expression of a protease or a polypeptide of the disclosure. Other suitable vectors would be apparent to persons skilled in the art.

[0345] In some embodiments, the host subject may be a cell that has been modified to express a protease or a polypeptide provided for herein. Such cells typically include prokaryotic cells such as bacterial cells, for example E. coli. In some embodiments, the host subject may be an eukaryotic cell. In some embodiments, the cell may be cultured using routine methods to produce a polypeptide of the disclosure.

[0346] In some embodiments, a vector is provided comprising the nucleic acid molecule or polynucleotide encoding a polypeptide as provided for herein. In some embodiments, the vector is a non-viral vector. In some embodiments, the vector is a viral vector, such as, but not limited to a lentivirus, an AAV vector, an AV vector, and the like. In some embodiments, the non-viral vector is a plasmid. In some embodiments, the non-viral vector is mRNA encoding the polypeptide. In some embodiments, the mRNA is encapsulated. In some embodiments, the mRNA is encapsulated in a liposome. The mRNA can contain modified nucleotides or a modified backbone to increase the mRNA half-life.

[0347] In some embodiments, a cell is provided comprising a nucleic acid molecule encoding a polypeptide as provided for herein. In some embodiments, a cell is provide comprising a vector as provided for herein. In some embodiments, the cell is a eukaryotic cell. In some embodiments, the cell is a human cell or a yeast cell. In some embodiments, the cell is not a bacterial cell. In some embodiments, the cell is a bacterial cell or a prokaryotic cell, such as, but not limited to E. coli. In some embodiments, the cell is not E. coli. In some embodiments, the cell is not a prokaryotic cell. In some embodiments, a cell is provide comprising a vector as provided for herein.

[0348] A polypeptide may be derivatized or modified to assist with their production, isolation or purification. For example, where a protease or a polypeptide of the disclosure is produced by recombinant expression in a host cell, the sequence of the polypeptide may include an additional methionine (M) residue at the N terminus to improve expression. As another example, the protease or the polypeptide of the disclosure may be derivatized or modified by addition of a leader sequence, as provided for herein.

[0349] The amino acid sequence of a polypeptide may be modified to include non-naturally occurring amino acids, for example to increase stability. When the polypeptides are produced by synthetic means, such amino acids may be introduced during production. The polypeptides may also be modified following either synthetic or recombinant production. Polypeptides may also be produced using D-amino acids. In such cases the amino acids will be linked in reverse sequence in the C- to N-orientation. This is conventional in the art for producing such polypeptides.

[0350] In some embodiments, methods of making a polypeptide as provided for herein are provided. In some embodiments, the methods comprise culturing a cell comprising a nucleic acid molecule or polynucleotide encoding the polypeptide. In some embodiments, the cell is as provided herein, such as the cells described above. In some embodiments, the cell is cultured under conditions suitable to facilitate the expression of the polypeptide.

[0351] In some embodiments, methods of making a nucleic acid sequence encoding the polypeptide are provided. In some embodiments, the methods comprise providing a vector comprising a polynucleotide sequence encoding a polypeptide having protease activity and inserting into the vector sequence encoding a variant Fc molecule to form an amino acid sequence encoding the polypeptide; or b) providing a vector comprising sequence encoding a variant Fc molecule and inserting into the vector sequence encoding a polypeptide having protease activity to form an amino acid sequence encoding the polypeptide, thereby making an nucleic acid sequence encoding the polypeptide.

[0352] The nucleic acid molecules can be transferred into a cell to produce the polypeptide by any means or methods, such as by transfection, electroporation, transduction, and the like.

ENUMERATED EMBODIMENTS

[0353] 1. A variant Fc polypeptide comprising an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a set of mutations selected from: [0354] L234A, L235A, G237A, Y296Q, and P329K; [0355] L234A, L235A, G237A, Y296Q, S298K, and P329K; [0356] L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K; or [0357] L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K; [0358] as compared to SEQ ID NO: 1.
2. The variant Fc polypeptide of embodiment 1, wherein the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 1.
3. The variant Fc polypeptide of embodiment 1, wherein the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 1.
4. The variant Fc polypeptide of embodiment 1, wherein the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 1.
5. The variant Fc polypeptide of embodiment 1, wherein the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 1.
6. The variant Fc polypeptide of any one of embodiments 1-5, wherein the variant Fc polypeptide comprises a set of mutations that prevent proteolytic cleavage.
7. The variant Fc polypeptide of any one of embodiments 1-5, wherein the variant Fc polypeptide comprises a set of mutations that prevent binding by a protease.
8. The variant Fc polypeptide of any one of embodiments 1-5, wherein the variant Fc polypeptide comprises a set of mutations that prevent proteolytic cleavage and binding by a protease.
9. A variant Fc polypeptide comprising an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, provided that the variant Fc polypeptide comprises a set of mutations selected from: [0359] L234A, L235A, G237A, Y296Q, and P329K; [0360] L234A, L235A, G237A, Y296Q, S298K, and P329K; [0361] L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K; or [0362] L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K; [0363] as compared to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
10. The variant Fc polypeptide of embodiment 9, wherein the variant IgG Fc comprises: [0364] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 19; [0365] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 20; [0366] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 21; [0367] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 22; [0368] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23; [0369] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 24; [0370] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 25; [0371] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 19; [0372] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 20; [0373] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 21; [0374] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 22; [0375] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 23; [0376] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 24; [0377] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 25; [0378] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 19; [0379] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 20; [0380] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 21; [0381] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 22; [0382] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23; [0383] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 24; [0384] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 25; [0385] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 19; [0386] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 20; [0387] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 21; [0388] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 22; [0389] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 23; [0390] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 24; or [0391] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 25.
11. The variant Fc polypeptide of any one of embodiments 9-10, wherein the variant Fc polypeptide comprises a set of mutations that prevent cleavage by a protease, or a variant thereof.
12. The variant Fc polypeptide of any one of embodiments 9-10, wherein the variant Fc polypeptide comprises a set of mutations that prevent binding by a protease, or a variant thereof.
13. The variant Fc polypeptide of any one of embodiments 9-12, wherein the variant Fc polypeptide comprises a set of mutations that prevent cleavage by a protease, or a variant thereof, and binding by a protease, or a variant thereof.
14. A variant Fc polypeptide comprising: [0392] an amino acid sequence of SEQ ID NO: 19; [0393] an amino acid sequence of SEQ ID NO: 21; [0394] an amino acid sequence of SEQ ID NO: 22; [0395] an amino acid sequence of SEQ ID NO: 23; [0396] an amino acid sequence of SEQ ID NO: 24; or [0397] an amino acid sequence of SEQ ID NO: 25.
15. The variant Fc polypeptide of any one of embodiments 1-14, wherein the variant Fc polypeptide is resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof.
16. The variant Fc polypeptide of any one of embodiments 1-15, wherein the variant Fc polypeptide is covalently or non-covalently conjugated to a polypeptide having IgG protease activity, wherein the polypeptide having IgG protease activity can be conjugated to N-terminus or C-terminus of the variant Fc polypeptide.
17. The variant Fc polypeptide of embodiment 15, wherein the polypeptide having IgG protease activity comprises an amino acid sequence having at least 50%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, or 55.
18. The variant Fc polypeptide of any one of embodiments 16-17, wherein the polypeptide having IgG protease activity comprises an amino acid sequence of SEQ ID NO: 26, 28, 29, 31, 36, 37, 38, 39, 40, 41, 50, 51, 52, or 55.
19. The variant Fc polypeptide of embodiment 17, wherein the polypeptide having IgG protease activity is as effective, or more effective at cleaving IgG than the wild-type protease, and/or is less immunogenic, or as immunogenic, as the wild-type protease.
20. A polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 35, provided that the polypeptide comprises any one, or more, mutations at positions selected from: 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 229, 229, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35.
21. The polypeptide of embodiment 20, wherein the polypeptide comprises a set of mutations at positions, as compared to SEQ ID NO: 35, selected from: [0398] a. 60, 61, 74, and 146; [0399] b. 60, 61, 63, 64, 74, 76, and 146; [0400] c. 227, and 229; [0401] d. 60, 64, 69, 112, 115, 116, 119, 120, 145, 146, 198, 223, 231, 241, 251, 273, 274, 278, 303, 314, and 334; [0402] e. 60, 61, 63, 64, 69, 74, 76, 112, 115, 116, 119, 120, 145, 146, 198, 223, 227, 229, 231, 241, 251, 273, 274, 278, 303, 314, and 334; [0403] f. 225; [0404] g. 85, 121, 154, 190, 289, and 303; [0405] h. 85, 121, 154, 190, 258, 289, and 303; [0406] i. 134, 190, 229, 289, and 336; [0407] j. 130, 134, 190, 229, 289, and 336; [0408] k. 85, 121, 130, 134, 154, 190, 229, 289, 303, and 336; [0409] l. 85, 121, 134, 154, 190, 229, 289, 303, and 336; [0410] m. 85, 121, 130, 134, 154, 190, 229, 258, 289, and 303; or [0411] n. 85, 121, 134, 154, 190, 229, 258, 289, 303, and 336.
22. The polypeptide of embodiment 21, wherein the polypeptide comprises the set of mutations at positions selected from: [0412] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0413] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, 336 as compared to SEQ ID NO: 35; [0414] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0415] 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; and [0416] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
23. The polypeptide of any one of embodiments 20-21, wherein the polypeptide comprises any one, or more, mutations selected from A60T, N61D, T63I, Q64K, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N229E, E229N, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303N, K314E, S334I, and N336Q, as compared to SEQ ID NO: 35.
24. The polypeptide of any one of embodiments 20-23, wherein the polypeptide comprises a set of mutations selected from: [0417] a. A60T, N61D, V74K, and H146S; [0418] b. A60T, N61D, T63I, Q64K, V74K, N76G, and H146S; [0419] c. F227L, and E229N; [0420] d. A60T, Q64Y, F69L, D112E, K115E, R116N, E119K, E120K, N145D, H146S, E198R, S223N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I; [0421] e. A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, D112E, K115E, R116N, E119K, E120K, N145D, H146S, E198R, S223N, F227L, E229N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I; [0422] f. H225Y; [0423] g. T85L, H121Y, E154D, N190D, A289P, and N303S; [0424] h. T85L, H121Y, E154D, N190D, V258G, A289P, and N303S; [0425] i. M134L, N190D, N229E, A289P, and N336Q; [0426] j. N130K, M134L, N190D, N229E, A289P, and N336Q; [0427] k. T85L, H121Y, N130K, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q; [0428] 1. T85L, H121Y, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q; [0429] m. T85L, H121Y, N130K, M134L, E154D, N190D, N229E, V258G, A289P, and N303S; or [0430] n. T85L, H121Y, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q.
25. The polypeptide of embodiment 23, wherein the polypeptide comprises a set of mutations selected from: [0431] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0432] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0433] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0434] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; and [0435] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
26. A polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 35, provided that the polypeptide comprises any one, or more, mutations at positions selected from: A60T, N61D, T63I, Q64K, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N229E, E229N, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303N, K314E, S334I, and N336Q, as compared to SEQ ID NO: 35, wherein the polypeptide has: [0436] a. increased stability; [0437] b. reduced, or no binding to an anti-drug antibody; [0438] c. increased expression in vitro; [0439] d. no T-cell binding epitope; and/or [0440] e. no chemical liabilities.
27. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of A60T, N61D, V74K, and H146S, and wherein the polypeptide has increased stability, and/or reduced, or no binding to an anti-drug antibody.
28. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64K, V74K, N76G, and H146S, and wherein the polypeptide has increased stability, and/or reduced, or no binding to an anti-drug antibody.
29. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of F227L, and E229N, and wherein the polypeptide has increased stability, and/or reduced, or no binding to an anti-drug antibody.
30. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of A60T, Q64Y, F69L, D112E, K115E, R116N, E119K, E120K, N145D, H146S, E198R, S223N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I, and wherein the polypeptide has increased stability, and/or reduced, or no binding to an anti-drug antibody.
31. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, D112E, K115E, R116N, E119K, E120K, N145D, H146S, E198R, S223N, F227L, E229N, N231T, K241Q, L251I, S273A, N274E, K278E, A303N, K314E, and S334I, and wherein the polypeptide has increased stability, and/or reduced, or no binding to an anti-drug antibody.
32. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of H225Y, and wherein the polypeptide has increased expression in vitro.
33. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of T85L, H121Y, E154D, N190D, A289P, and N303S, and wherein the polypeptide does not bind to a T-cell.
34. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of T85L, H121Y, E154D, N190D, V258G, A289P, and N303S, and wherein the polypeptide does not bind to a T-cell.
35. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of M134L, N190D, N229E, A289P, and N336Q, and wherein the polypeptide has no chemical liabilities.
36. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of N130K, M134L, N190D, N229E, A289P, and N336Q, and wherein the polypeptide has no chemical liabilities.
37. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of T85L, H121Y, N130K, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, and wherein the polypeptide has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities.
38. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of T85L, H121Y, M134L, E154D, N190D, N229E, A289P, N303S, and N336Q, and wherein the polypeptide has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities.
39. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of T85L, H121Y, N130K, M134L, E154D, N190D, N229E, V258G, A289P, and N303S, and wherein the polypeptide has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities.
40. The polypeptide of embodiment 26, wherein the polypeptide comprises a set of mutations of T85L, H121Y, M134L, E154D, N190D, N229E, V258G, A289P, N303S, and N336Q, and wherein the polypeptide has increased stability, reduced, or no binding to an anti-drug antibody, no T-cell binding epitope, and/or no chemical liabilities.
41. A polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, 1295, 1301, 1303, or 1310, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35.
42. The polypeptide of embodiment 41, wherein the polypeptide comprises the set of mutations at positions selected from: [0441] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0442] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0443] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0444] 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; and [0445] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
43. The polypeptide of embodiment 42, wherein the polypeptide comprises: [0446] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0447] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0448] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0449] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; or [0450] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
44. The polypeptide of embodiment 41, wherein the mutation, or the mutation set is selected from any one, or any combination of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
45. The polypeptide of embodiment 44, wherein the polypeptide comprises a set of mutations selected from: [0451] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0452] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0453] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0454] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; and [0455] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
46. The polypeptide of embodiment 41, wherein the polypeptide comprises: [0456] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0457] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0458] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0459] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; or [0460] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
47. The polypeptide of embodiment 41, wherein the polypeptide comprises an amino acid sequence selected from any one of SEQ ID NOs: 1290, 1295, 1301, 1303, or 1310.
48. A polypeptide comprising an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 55-1019, 1290-1310 and 1333.
49. The polypeptide of embodiment 48, wherein the polypeptide has protease activity.
50. The polypeptide of any one of embodiments 48-49, wherein the polypeptide having protease activity is a polypeptide having IgG cleaving protease activity.
51. The polypeptide of embodiment 50, wherein the polypeptide having IgG cleaving protease activity is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant. 52. The polypeptide of embodiment 51, wherein the IdeS, IdeZ, IdeZ2, or Ide85 protease variant has the same or improved protease activity as compared to wild-type IdeS, IdeZ, IdeZ2, or Ide85 protease.
53. The polypeptide of any one of embodiments 48-52, wherein the polypeptide comprises the amino acid sequence of any one of SEQ ID NO: 55-1019, 1290-1310 and 1333.
54. The polypeptide of any one of embodiments 48-53, wherein the polypeptide has an increased or decreased recognition by an anti-protease antibody.
55. The polypeptide of any one of embodiments 48-54, wherein the polypeptide further does not comprise a methionine (M) amino acid residue at the N-terminus of said polypeptide.
56. The polypeptide of any one of embodiments 48-55, wherein the polypeptide comprises a methionine (M) amino acid residue at the N-terminus of said polypeptide.
57. The polypeptide of any one of embodiments 48-56, wherein the polypeptide does not comprise a His-tag at the C-terminus of said polypeptide.
58. The polypeptide of any one of embodiments 48-57, wherein the polypeptide comprises a His-tag at the C-terminus of said polypeptide.
59. A polypeptide comprising an amino acid of any one of SEQ ID NO: 1290-1310 and 1333.
60. The polypeptide of embodiment 59, wherein the polypeptide has protease activity.
61. The polypeptide of any one of embodiments 59-60, wherein the polypeptide having protease activity is a polypeptide having IgG cleaving protease activity.
62. The polypeptide of any one of embodiments 59-61, wherein the polypeptide has an increased or decreased recognition by an anti-protease antibody.
63. The polypeptide of any one of embodiments 59-62, wherein the polypeptide has increased, decreased, or equal activity to wild-type IdeS protease.
64. A polypeptide having an amino acid sequence of any one of SEQ ID NOs: 1290, 1295, 1301, 1303, or 1310.
65. The polypeptide of any one of embodiments 20-64, wherein the polypeptide is less immunogenic than a wild-type protease.
66. The polypeptide of any one of embodiments 20-64, wherein the polypeptide is as immunogenic than a wild-type protease.
67. The polypeptide of any one of embodiments 65-66, wherein the wild-type protease is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant
68. A molecule comprising: [0461] a polypeptide comprising an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 55-1019, 1290-1310 and 1333; and [0462] an Fc polypeptide, [0463] wherein the polypeptide is covalently or non-covalently connected (e.g. conjugated via a peptide bond or through electrostatic interactions) to the Fc polypeptide.
69. The molecule of embodiment 68, wherein the polypeptide is a polypeptide having protease activity.
70. The molecule of embodiment 69, wherein the polypeptide having protease activity is a polypeptide having IgG cleaving protease activity.
71. The molecule of embodiment 70, wherein the polypeptide having IgG cleaving protease activity is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant.
72. The molecule of any one of embodiments 68-71, wherein the polypeptide comprises the amino acid sequence of any one of SEQ ID NO: 55-1019, 1290-1310 and 1333.
73. The molecule of any one of embodiments 68-72, wherein the polypeptide has an increased or decreased recognition by an anti-protease antibody.
74. The molecule of any one of embodiments 68-73, wherein the polypeptide has increased, decreased, or equal activity to wild-type IdeS, IdeZ, IdeZ2, or Ide85 protease.
75. The molecule of any one of embodiments 68-74, wherein the polypeptide further does not comprise a methionine (M) amino acid residue at the N-terminus of said polypeptide.
76. The molecule of any one of embodiments 68-75, wherein the polypeptide comprises a methionine (M) amino acid residue at the N-terminus of said polypeptide.
77. The molecule of embodiment 68, wherein the Fc polypeptide is resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof.
78. The molecule of any one of embodiments 68-77, wherein the Fc polypeptide is a variant Fc polypeptide.
79. The molecule of embodiment 78, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation set selected from: [0464] L234A, L235A, G237A, Y296Q, and P329K; [0465] L234A, L235A, G237A, Y296Q, S298K, and P329K; [0466] L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K; or [0467] L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K.
80. The molecule of any one of embodiments 78-79, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, Y296Q, and P329K according to SEQ ID NO: 1.
81. The molecule of any one of embodiments 78-79, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, Y296Q, S298K, and P329K according to SEQ ID NO: 1.
82. The molecule of any one of embodiments 78-79, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K according to SEQ ID NO: 1.
83. The molecule of any one of embodiments 78-79, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K according to SEQ ID NO: 1.
84. The molecule of any one of embodiments 78-83, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, provided that the variant Fc polypeptide comprises a set of mutations selected from: [0468] L234A, L235A, G237A, Y296Q, and P329K; [0469] L234A, L235A, G237A, Y296Q, S298K, and P329K; [0470] L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K; or [0471] L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K; [0472] as compared to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
85. The molecule of embodiment 84, wherein the variant IgG Fc comprises: [0473] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 19; [0474] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 20; [0475] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 21; [0476] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 22; [0477] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23; [0478] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 24; [0479] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 25; [0480] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 19; [0481] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 20; [0482] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 21; [0483] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 22; [0484] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 23; [0485] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 24; [0486] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 25; [0487] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 19; [0488] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 20; [0489] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 21; [0490] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 22; [0491] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23; [0492] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 24; [0493] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 25; [0494] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 19; [0495] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 20; [0496] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 21; [0497] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 22; [0498] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 23; [0499] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 24; or [0500] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 25.
86. The molecule of any one of embodiments 78-85, wherein the variant Fc polypeptide comprises: [0501] an amino acid sequence of SEQ ID NO: 19; [0502] an amino acid sequence of SEQ ID NO: 21; [0503] an amino acid sequence of SEQ ID NO: 22; [0504] an amino acid sequence of SEQ ID NO: 23; [0505] an amino acid sequence of SEQ ID NO: 24; or [0506] an amino acid sequence of SEQ ID NO: 25.
87. The molecule of any one of embodiments 68-86, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of the Fc polypeptide.
88. The molecule of any one of embodiments 68-86, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to the C-terminus of the Fc polypeptide.
89. The molecule of any one of embodiments 68-88, wherein the polypeptide having protease activity is conjugated to the C-terminus of the Fc polypeptide via a peptide linker.
90. The molecule of any one of embodiments 68-88, wherein the polypeptide having protease activity is conjugated to the N-terminus of the Fc polypeptide via a peptide linker.
91. The molecule of any one of embodiments 68-90, wherein the peptide linker is a glycine/serine linker.
92. The molecule of any one of embodiments 68-91, wherein the polypeptide optionally comprises a nanobody.
93. The molecule of embodiment 92, wherein the nanobody comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 30, 32, or 33.
94. The molecule of any one of embodiments 92-93, wherein the nanobody is covalently or non-covalently conjugated to the N-terminus or the C-terminus of the polypeptide having protease activity.
95. The molecule of embodiment 94, wherein the nanobody is covalently or non-covalently conjugated to the N-terminus of the Fc polypeptide, and wherein the C-terminus of the Fc polypeptide is covalently or non-covalently conjugated to the N-terminus of the polypeptide having protease activity.
96. The molecule of embodiment 94, wherein the nanobody is covalently or non-covalently conjugated to the C-terminus of the Fc polypeptide, and wherein the N-terminus of the Fc polypeptide is covalently or non-covalently conjugated to the C-terminus of the polypeptide having protease activity.
97. The molecule of any one of embodiments 68-96, wherein the polypeptide optionally comprises a His-tag.
98. The molecule of embodiment 97, wherein the His-tag is covalently or non-covalently conjugated to the C-terminus or the N-terminus of the polypeptide.
99. The molecule of any one of embodiments 97-98, wherein the His-tag has the amino acid sequence of SEQ ID NO: 27, or 34.
100. The molecule of any one of embodiments 68-99, wherein the polypeptide self-associates, or associates with another polypeptide, to form a dimer.
101. The molecule of embodiment 100, wherein the dimer is a homodimer or a heterodimer.
102. The molecule of any one of embodiments 100-101, wherein the dimer comprises a first polypeptide and a second polypeptide.
103. The molecule of embodiment 102, wherein: [0507] the first polypeptide comprises the polypeptide of any one of embodiments 55-89; and [0508] the second polypeptide comprises the polypeptide of any one of embodiments 55-89.
104. A molecule comprising: [0509] a polypeptide comprising an amino acid sequence of any one of SEQ ID NO: 1290-1310 and 1333; and [0510] an Fc polypeptide, [0511] wherein the polypeptide is covalently or non-covalently connected (e.g. conjugated via a peptide bond or through electrostatic interactions) to the Fc polypeptide.
105. The molecule of embodiment 104, wherein the polypeptide comprises the amino acid sequence of any one of SEQ ID NO: 1290-1310 and 1333.
106. The molecule of any one of embodiments 104-105, wherein the polypeptide is a polypeptide having protease activity.
107. The molecule of embodiment 106, wherein the polypeptide having protease activity is a polypeptide having IgG cleaving protease activity.
108. The molecule of embodiment 107, wherein the polypeptide having IgG cleaving protease activity is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant.
109. The molecule of any one of embodiments 104-108, wherein the polypeptide has increased, decreased, or equal activity to wild-type IdeS, IdeZ, IdeZ2, or Ide85 protease.
110. The molecule of any one of embodiments 104-109, wherein the polypeptide has an increased or decreased recognition by an anti-protease antibody.
111. The molecule of any one of embodiments 104-110, wherein the polypeptide further does not comprise a methionine (M) amino acid residue at the N-terminus of said polypeptide.
112. The molecule of any one of embodiments 104-110, wherein the polypeptide comprises a methionine (M) amino acid residue at the N-terminus of said polypeptide.
113. The molecule of embodiment 104, wherein the Fc polypeptide is resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof.
114. The molecule of any one of embodiments 104-113, wherein the Fc polypeptide is a variant Fc polypeptide.
115. The molecule of embodiment 114, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 1, provided that the variant Fc polypeptide comprises a mutation set selected from: [0512] L234A, L235A, G237A, Y296Q, and P329K; [0513] L234A, L235A, G237A, Y296Q, S298K, and P329K; [0514] L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K; or [0515] L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K.
116. The molecule of any one of embodiments 114-115, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, Y296Q, and P329K according to SEQ ID NO: 1.
117. The molecule of any one of embodiments 114-115, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, Y296Q, S298K, and P329K according to SEQ ID NO: 1.
118. The molecule of any one of embodiments 114-115, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K according to SEQ ID NO: 1.
119. The molecule of any one of embodiments 114-115, wherein the variant Fc polypeptide comprises mutations corresponding to L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K according to SEQ ID NO: 1.
120. The molecule of any one of embodiments 114-119, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25, provided that the variant Fc polypeptide comprises a set of mutations selected from: [0516] L234A, L235A, G237A, Y296Q, and P329K; [0517] L234A, L235A, G237A, Y296Q, S298K, and P329K; [0518] L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K; or [0519] L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K; [0520] as compared to SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
121. The molecule of embodiment 120, wherein the variant IgG Fc comprises: [0521] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 19; [0522] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 20; [0523] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 21; [0524] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 22; [0525] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23; [0526] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 24; [0527] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 25; [0528] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 19; [0529] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 20; [0530] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 21; [0531] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 22; [0532] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 23; [0533] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 24; [0534] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 25; [0535] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 19; [0536] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 20; [0537] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 21; [0538] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 22; [0539] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23; [0540] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 24; [0541] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, and P329K mutations, as compared to SEQ ID NO: 25; [0542] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 19, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 19; [0543] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 20, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 20; [0544] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 21, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 21; [0545] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 22, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 22; [0546] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 23; [0547] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 24, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 24; or [0548] an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 25, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, D265K, E269S, Y296Q, S298K, and P329K mutations, as compared to SEQ ID NO: 25.
122. The molecule of any one of embodiments 114-121, wherein the variant Fc polypeptide comprises: [0549] an amino acid sequence of SEQ ID NO: 19; [0550] an amino acid sequence of SEQ ID NO: 21; [0551] an amino acid sequence of SEQ ID NO: 22; [0552] an amino acid sequence of SEQ ID NO: 23; [0553] an amino acid sequence of SEQ ID NO: 24; or [0554] an amino acid sequence of SEQ ID NO: 25.
123. The molecule of any one of embodiments 104-122, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to the N-terminus of the Fc polypeptide.
124. The molecule of any one of embodiments 104-122, wherein the polypeptide having protease activity is covalently or non-covalently conjugated to the C-terminus of the Fc polypeptide.
125. The molecule of any one of embodiments 104-124, wherein the polypeptide having protease activity is conjugated to the C-terminus of the Fc polypeptide via a peptide linker.
126. The molecule of any one of embodiments 104-124, wherein the polypeptide having protease activity is conjugated to the N-terminus of the Fc polypeptide via a peptide linker.
127. The molecule of any one of embodiments 104-126, wherein the peptide linker is a glycine/serine linker.
128. The molecule of any one of embodiments 104-127, wherein the polypeptide optionally comprises a nanobody.
129. The molecule of embodiment 128, wherein the nanobody comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 30, 32, or 33.
130. The molecule of any one of embodiments 128-129, wherein the nanobody is covalently or non-covalently conjugated to the N-terminus or the C-terminus of the polypeptide having protease activity.
131. The molecule of embodiment 130, wherein the nanobody is covalently or non-covalently conjugated to the N-terminus of the Fc polypeptide, and wherein the C-terminus of the Fc polypeptide is covalently or non-covalently conjugated to the N-terminus of the polypeptide having protease activity.
132. The molecule of embodiment 130, wherein the nanobody is covalently or non-covalently conjugated to the C-terminus of the Fc polypeptide, and wherein the N-terminus of the Fc polypeptide is covalently or non-covalently conjugated to the C-terminus of the polypeptide having protease activity.
133. The molecule of any one of embodiments 104-132, wherein the polypeptide optionally comprises a His-tag.
134. The molecule of embodiment 133, wherein the His-tag is covalently or non-covalently conjugated to the C-terminus or the N-terminus of the polypeptide.
135. The molecule of any one of embodiments 133-134, wherein the His-tag has the amino acid sequence of SEQ ID NO: 27, or 34.
136. The molecule of any one of embodiments 104-135, wherein the polypeptide self-associates, or associates with another polypeptide, to form a dimer.
137. The molecule of embodiment 136, wherein the dimer is a homodimer or a heterodimer.
138. The molecule of any one of embodiments 136-137, wherein the dimer comprises a first polypeptide and a second polypeptide.
139. The molecule of embodiment 138, wherein: [0555] the first polypeptide comprises the polypeptide of any one of embodiments 104-138; and [0556] the second polypeptide comprises the polypeptide of any one of embodiments 104-138.
140. A molecule comprising an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336.
141. The molecule of embodiment 140, wherein the polypeptide comprises a polypeptide having protease activity.
142. The molecule of embodiment 141, wherein the polypeptide having protease activity is a polypeptide having IgG cleaving protease activity.
143. The molecule of embodiment 142, wherein the polypeptide having IgG cleaving protease activity is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant.
144. The molecule of any one of embodiments 140-143, wherein the polypeptide has increased, decreased, or equal activity to wild-type IdeS, IdeZ, IdeZ2, or Ide85 protease.
145. The molecule of any one of embodiments 140-144, wherein the polypeptide having protease activity comprises an amino acid sequence selected from any one of SEQ ID NO: 753-1019, 1290-1310 and 1333.
146. The molecule of any one of embodiments 140-145, wherein the polypeptide has an increased or decreased recognition by an anti-protease antibody.
147. The molecule of embodiment 146, wherein the polypeptide comprises an Fc polypeptide.
148. The molecule of embodiment 147, wherein the Fc polypeptide is resistant to cleavage by a protease, or a variant thereof, and/or binding by a protease, or a variant thereof.
149. The molecule of any one of embodiments 147-148, wherein the Fc polypeptide is a variant Fc polypeptide.
150. The molecule of embodiment 149, wherein the variant Fc polypeptide comprises an amino acid sequence having at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identity to SEQ ID NO: 23, provided that the variant Fc polypeptide comprises a set of L234A, L235A, G237A, Y296Q, and P329K mutations, as compared to SEQ ID NO: 23;
151. The molecule of any one of embodiments 149-150, wherein the variant Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23.
152. The molecule of any one of embodiments 140-151, wherein the polypeptide comprises the amino acid sequence of any one of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336.
153. The molecule of any one of embodiments 140-152, wherein the polypeptide self-associates, or associates with another polypeptide, to form a dimer.
154. The molecule of embodiment 153, wherein the dimer is a homodimer or a heterodimer.
155. The molecule of any one of embodiments 153-154, wherein the dimer comprises a first polypeptide and a second polypeptide.
156. The molecule of embodiment 155, wherein: [0557] the first polypeptide comprises the polypeptide of any one of embodiments 140-155; and [0558] the second polypeptide comprises the polypeptide of any one of embodiments 140-155.
157. A molecule comprising: [0559] an Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and [0560] a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35, [0561] wherein the polypeptide is linked or conjugated to N- or C-terminus of the Fc polypeptide.
158. The molecule of embodiment 157, wherein the Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
159. The molecule of embodiment 158, wherein the mutation, or the set of mutations is selected from any one, or any combination of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
160. The molecule of embodiment 158, wherein the Fc polypeptide comprises the set of mutations of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
161. The molecule of embodiment 157, wherein the polypeptide comprises the set of mutations at positions selected from: [0562] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0563] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, 336 as compared to SEQ ID NO: 35; [0564] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0565] 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; and [0566] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
162. The molecule of embodiment 157, wherein the polypeptide comprises the mutation, or the mutation set selected from any one, or any combination of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
163. The molecule of embodiment 162, wherein the polypeptide comprises a set of mutations selected from: [0567] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0568] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0569] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0570] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; and [0571] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
164. A molecule comprising: [0572] an Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and [0573] a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, 1295, 1301, 1303, or 1310, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35, [0574] wherein the polypeptide is linked or conjugated to N- or C-terminus of the Fc polypeptide.
165. The molecule of embodiment 164, wherein the Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
166. The molecule of embodiment 165, wherein the mutation, or the set of mutations is selected from any one, or any combination of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
167. The molecule of embodiment 166, wherein the Fc polypeptide comprises the set of mutations of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
168. The molecule of embodiment 164, wherein the Fc polypeptide comprises the amino acid sequence of SEQ ID NO: 23.
169. The molecule of embodiment 164, wherein the polypeptide comprises the set of mutations at positions selected from: [0575] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0576] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0577] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0578] 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; and [0579] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
170. The molecule of embodiment 164, wherein the polypeptide comprises: [0580] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0581] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0582] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0583] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; or [0584] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
171. The molecule of embodiment 164, wherein the polypeptide comprises the mutation, or the mutation set selected from any one, or any combination of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
172. The molecule of embodiment 164, wherein the polypeptide comprises a set of mutations selected from: [0585] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0586] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0587] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0588] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; and [0589] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
173. The molecule of embodiment 164, wherein the polypeptide comprises: [0590] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0591] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0592] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0593] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; or [0594] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
174. The molecule of embodiment 164, wherein the polypeptide comprises an amino acid sequence selected from any one of SEQ ID NOs: 1290, 1295, 1301, 1303, or 1310.
175. A molecule comprising: [0595] an Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; and [0596] a polypeptide having an amino acid sequence of any one of SEQ ID NOs: 1290, 1295, 1301, 1303, or 1310, [0597] wherein the polypeptide is linked or conjugated to N- or C-terminus of the Fc polypeptide.
176. The molecule of embodiment 175, comprising from N- to C-terminus: [0598] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290; [0599] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295; [0600] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301; [0601] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303; [0602] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310; [0603] the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0604] the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0605] the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0606] the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; or [0607] the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23.
177. A molecule comprising: [0608] i. a dimer Fc molecule comprising: [0609] a first Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1(WT), provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and [0610] a second Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1(WT), provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1, [0611] wherein the first Fc polypeptide and the second Fc polypeptide associate with each other to form the dimer Fc molecule; and [0612] ii. a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 35, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35, [0613] wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide.
178. The molecule of embodiment 177, wherein the Fc dimer molecule is a homodimer.
179. The molecule of embodiment 177, wherein the Fc dimer molecule is a heterodimer.
180. The molecule of embodiment 177, wherein the first Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
181. The molecule of embodiment 177, wherein the second Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
182. The molecule of embodiment 177, wherein: [0614] the first Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and [0615] the second Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
183. The molecule of embodiment 182, wherein the mutation, or the set of mutations is selected from any one, or any combination of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
184. The molecule of embodiment 183, wherein: [0616] the first Fc polypeptide comprises the set of mutations of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1; and [0617] the second Fc polypeptide comprises the set of mutations of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
185. The molecule of embodiment 177, wherein the polypeptide comprises the set of mutations at positions selected from: [0618] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0619] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, 336 as compared to SEQ ID NO: 35; [0620] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0621] 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; and [0622] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
186. The molecule of embodiment 177, wherein the polypeptide comprises the mutation, or the mutation set selected from any one, or any combination of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
187. The molecule of embodiment 177, wherein the polypeptide comprises the set of mutations selected from: [0623] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0624] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0625] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0626] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; and [0627] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
188. A molecule comprising: [0628] i. a dimer Fc molecule comprising: [0629] a first Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and [0630] a second Fc polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23, provided that the Fc polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1, [0631] wherein the first Fc polypeptide and the second Fc polypeptide associate with each other to form the dimer Fc molecule; and [0632] ii. a polypeptide comprising an amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, 1295, 1301, 1303, or 1310, provided that the polypeptide comprises a mutation, or a set of mutations at any one position, or any combination of positions selected from 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 261, 273, 274, 278, 286, 289, 303, 314, 334, and 336, as compared to SEQ ID NO: 35, [0633] wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide.
189. The molecule of embodiment 188, wherein the Fc dimer molecule is a homodimer.
190. The molecule of embodiment 188, wherein the Fc dimer molecule is a heterodimer.
191. The molecule of embodiment 188, wherein the first Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
192. The molecule of embodiment 188, wherein the second Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
193. The molecule of embodiment 188, wherein: [0634] the first Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1; and [0635] the second Fc polypeptide comprises the set of mutations at positions 234, 235, 237, 296, and 329 as compared to SEQ ID NO: 1.
194. The molecule of embodiment 193, wherein the mutation, or the set of mutations is selected from any one, or any combination of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
195. The molecule of embodiment 194, wherein: [0636] the first Fc polypeptide comprises the set of mutations of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1; and [0637] the second Fc polypeptide comprises the set of mutations of L234A, L235A, G237A, Y296Q, and P329K as compared to SEQ ID NO: 1.
196. The molecule of embodiment 188, wherein the first Fc polypeptide comprises the amino acid sequence of SEQ ID NO: 23, and the second Fc polypeptide comprises the amino acid sequence of SEQ ID NO: 23.
197. The molecule of embodiment 188, wherein the polypeptide comprises the set of mutations at positions selected from: [0638] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0639] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0640] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0641] 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; and [0642] 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35.
198. The molecule of embodiment 188, wherein the polypeptide comprises: [0643] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0644] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 258, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0645] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 273, 274, 278, 286, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35; [0646] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, and 334 as compared to SEQ ID NO: 35; or [0647] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations at positions 60, 61, 63, 64, 69, 74, 76, 85, 112, 115, 116, 119, 120, 121, 130, 134, 145, 146, 154, 190, 198, 223, 225, 227, 231, 241, 251, 261, 273, 274, 278, 289, 303, 314, 334, and 336 as compared to SEQ ID NO: 35. 199. The molecule of embodiment 188, wherein the polypeptide comprises the mutation, or the mutation set selected from any one, or any combination of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, N261G, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
200. The molecule of embodiment 188, wherein the polypeptide comprises a set of mutations selected from: [0648] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0649] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0650] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0651] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; and [0652] A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
201. The molecule of embodiment 188, wherein the polypeptide comprises: [0653] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1290, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0654] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1295, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, V258G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0655] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1301, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, S273A, N274E, K278E, D286N, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35; [0656] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, R116N, E119K, E120K, H121Y, N130G, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, and S334I as compared to SEQ ID NO: 35; or [0657] the amino acid sequence having at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1310, provided that the polypeptide comprises the set of mutations of A60T, N61D, T63I, Q64Y, F69L, V74K, N76G, T85L, D112E, K115E, R116N, E119K, E120K, H121Y, N130K, M134L, N145D, H146S, E154D, N190D, E198R, S223N, H225Y, F227L, N231T, K241Q, L251I, N261G, S273A, N274E, K278E, A289P, A303S, K314E, S334I, and N336Q as compared to SEQ ID NO: 35.
202. The molecule of embodiment 188, wherein the polypeptide comprises the amino acid sequence selected from any one, or any combination of SEQ ID NOs: 1290, 1295, 1301, 1303, or 1310.
203. A molecule comprising: [0658] a dimer Fc molecule comprising a first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and a second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, wherein the first Fc polypeptide and the second Fc polypeptide associate with each other to form the dimer Fc molecule; and [0659] a polypeptide having an amino acid sequence of any one, or any combination of SEQ ID NOs: 1290, 1295, 1301, 1303, and 1310, [0660] wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide.
204. The molecule of embodiment 203, wherein the Fc dimer molecule is a homodimer.
205. The molecule of embodiment 203, wherein the Fc dimer molecule is a heterodimer.
206. The molecule of embodiment 203, comprising: [0661] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide; [0662] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide; [0663] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide; [0664] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide; [0665] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310, wherein the polypeptide is linked or conjugated to N- or C-terminus of the first Fc polypeptide and/or the second Fc polypeptide; [0666] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0667] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0668] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0669] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0670] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0671] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0672] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0673] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0674] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0675] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0676] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0677] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0678] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0679] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0680] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0681] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1303, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0682] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0683] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; [0684] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301 is linked or conjugated to N- or C-terminus of the second Fc polypeptide; or [0685] the dimer Fc molecule comprising the first Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the second Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303, wherein the polypeptide having an amino acid sequence of SEQ ID NO: 1310 is linked or conjugated to N- or C-terminus of the first Fc polypeptide, and the polypeptide having an amino acid sequence of SEQ ID NO: 1303 is linked or conjugated to N- or C-terminus of the second Fc polypeptide.
207. A molecule comprising an amino acid sequence of any one of SEQ ID NO: 1023-1289, 1311-1329, and 1334-1336.
208. The molecule of embodiment 207, wherein the polypeptide comprises a polypeptide having protease activity.
209. The molecule of embodiment 208, wherein the polypeptide having protease activity is a polypeptide having IgG cleaving protease activity.
210. The molecule of embodiment 209, wherein the polypeptide having IgG cleaving protease activity is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant.
211. The molecule of any one of embodiments 207-210, wherein the polypeptide has increased, decreased, or equal activity to wild-type IdeS, IdeZ, IdeZ2, or Ide85 protease.
212. The molecule of any one of embodiments 207-211, wherein the polypeptide has an increased or decreased recognition by an anti-protease antibody.
213. The molecule of any one of embodiments 207-212, wherein the polypeptide self-associates, or associates with another polypeptide, to form a dimer.
214. The molecule of embodiment 213, wherein the dimer is a homodimer or a heterodimer.
215. The molecule of any one of embodiments 213-214, wherein the dimer comprises a first polypeptide and a second polypeptide.
216. The molecule of embodiment 215, wherein: [0686] the first polypeptide comprises the polypeptide of any one of embodiments 207-215; and [0687] the second polypeptide comprises the polypeptide of any one of embodiments 207-215.
217. The molecule of any one of embodiments 68-216, wherein the polypeptide is less immunogenic than a wild-type protease.
218. The molecule of any one of embodiments 68-216, wherein the polypeptide is as immunogenic than a wild-type protease.
219. The molecule of any one of embodiments 217-218, wherein the wild-type protease is selected from IdeS, IdeZ, IdeZ2, or Ide85 protease variant
220. A pharmaceutical composition comprising the polypeptide of any one of embodiments 1-67, or the molecule of any one of embodiments 68-219.
221. A method of treating a disease or disorder in a subject, the method comprising administering the polypeptide of any of embodiments 1-67, the molecule of any one of embodiments 68-219, or the pharmaceutical composition of embodiment 220, to the subject to treat the disease or disorder.
222. The method of embodiment 221, wherein the disease or disorder is selected from Addison's disease, Anti-GBM glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated vasculitides, ANCA associated vasculitis, granulomatous polyangiitis (Wegener granulomatosis), eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), microscopic polyangiitis, anti-NMDAR encephalitis, anti-phospholipid antibody syndrome (APS) and catastrophic APS, autoimmune bullous skin diseases, pemphigus, pemphigus foliaceus (PF), fogo selvage (FS), pemphigus vulgaris (PV), autoimmune hemolytic anemia (AIHA), autoimmune hepatitis (AIH), autoimmune neutropenia (AIN), bullous pemphigoid (BP), Celiac's disease, chronic urticaria, complete congenital heart block (CCHB), diabetes type 1A (T1DM), epidermolysis bullosa acquisita (EBA), essential mixed cryoglobulinemia, Goodpasture's syndrome, anti-glomerular basement membrane disease, Graves' disease, Goitre, hyperthyroidism, infiltrative exophthalmos, infiltrative dermopathy, Guillain-Barre syndrome (GBS), acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), hemophilia, acquired FVII deficiency, idiopathic thrombocytopenic purpura (ITP), Lambert-Eaton myasthenic syndrome (LEMS), mixed connective tissue disease (MCTD), multiple myeloma, myasthenia gravis, myasthenic crisis, myocarditis, dilated cardiomyopathy (DCM), congestive cardiomyopathy, neuromyelitis optica (NMO), primary biliary cirrhosis (PBC), primary progressive multiple sclerosis (PPMS), relapsing-rheumatic multiple sclerosis, acute exacerbation of multiple sclerosis, rheumatic heart disease (RHD), rheumatoid arthritis (RA), serum-sickness, immune complex hypersensitivity (type III), Sj?gren's syndrome (SS), lupus nephritis, systemic lupus erythematosus (SLE), cutaneous lupus (CLE), transplant rejection, thrombotic thrombocytopenic purpura (TTP), idiopathic inflammatory myopathies, polymyositis, dermatomyositis, inclusion body myositis, uveitis, scleritis, ankylosing spondylitis, axial spondyloarthritis, reactive arthritis, psoriatic arthritis, IBD-associated arthritis, antiphospholipid syndrome, systemic sclerosis, giant cell arteritis, polymyalgia rheumatic, Takayasu's arteritis, anti-neutrophil cytoplasmic antibody associated vasculitis, Henoch-Schonlein purpura, polyarteritis nodosa, Cogan's syndrome, Buerger's disease, Susan's disease, immune complex vasculitis, primary angiitis of the central nervous system (CNS), Behcet's disease, relapsing polychondritis, juvenile idiopathic arthritis, juvenile dermatomyositis, autoimmune brain disease, sarcoidosis, neurosarcoidosis, IgG4-related diseases, autoimmune complications of immune checkpoint inhibitors (IRAEs), adult onset Still's disease, warm antibody hemolytic anemia (wAIHA), immune thrombocytopenia, immune thrombotic thrombocytopenia, thrombic thrombocytopenia, pernicious anemia, aplastic anemia, Evan's syndrome, autoimmune neutropenia, acquired von Willibrand syndrome, recurring fetal loss, Rh mismatch, ulcerative colitis, autoimmune hepatitis, autoimmune pancreatitis, eosinophilic esophagitis/gastritis, primary sclerosing cholangitis, primary biliary sclerosis, glomerulonephritis, glomerular basement membrane disease, scleritis/episcleritis, uveitis, conjunctivitis, keratitis, type I diabetes mellitus, Hashimoto's thyroiditis, polyglandular autoimmune endocrine syndromes, atopic dermatitis, dermatitis herpetiformis, pemphigus foliaceus, fogo selvagem, cutaneous lupus erythematosus, linear IgA disease, Lichen planus, transplantation, antibody-mediated rejection, alloantibody hypersensitization, xenoantibody mediated rejection, solid organ rejection, graft vs. host disease (GVHD), multiple sclerosis, neuromyelitis optica, amyotrophic lateral sclerosis, Parkinson's disease, autoimmune encephalitis, CNS vasculitis, chronic idiopathic demyletinating polyneuropathy, transverse myelitis, optic neuritis, anti-myelin oligodendrocyte glycoprotein (MOG) disease, chronic meningitis, rheumatic heart disease, infectious disease, vaccination, antibody dependent enhancement, antibody to therapeutic biologic agents (cytokines, monoclonal antibodies, enzymes, coagulation factors), allergic asthma, eosinophilic pneumonia, nonspecific interstitial pneumonia, rheumatoid arthritis-associated interstitial lung disease (RA-ILD), sarcoidosis, hypersensitive pneumonitis, allergic bronchopulmonary mycosis, chronic rhinosinusitis with nasal polyps, or any combination thereof.
223. A method of treating a transplant subject comprising administering a therapeutically effective amount of the polypeptide of any of embodiments 1-67, the molecule of any one of embodiments 68-219, or the pharmaceutical composition of embodiment 220, to the subject, thereby treating the transplant (recipient) subject.
224. A method of improving a gene-therapy in subject comprising administering a therapeutically effective amount of the polypeptide of any of embodiments 1-67, the molecule of any one of embodiments 68-219, or the pharmaceutical composition of embodiment 220, to the subject, thereby improving the gene-therapy in the subject.
225. A method of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder, comprising administering a therapeutically effective amount of the polypeptide of any embodiments 1-67, the molecule of any one of embodiments 68-219, or the pharmaceutical composition of embodiment 220, thereby treating the subject.
226. A method of cleaving B cell receptor, the method comprising administering a therapeutically effective amount of the polypeptide of any of embodiments 1-67, the molecule of any one of embodiments 68-219, or the pharmaceutical composition of embodiment 220, to cleave the B cell receptor.
227. The method of embodiment 226, wherein the polypeptide is administered to a cell, a tissue, an animal, or a subject.
228. The method of embodiment 227, wherein the cell, the tissue, the animal, or the subject is any cell, tissue, animal, or subject.
229. A nucleic acid encoding the polypeptide of any of embodiments 1-67 or the molecule of any one of embodiments 68-219.
230. A vector comprising the nucleic acid of embodiment 229.
231. A cell comprising the nucleic acid of embodiment 229 or the vector of embodiment 230.
232. A method of making the polypeptide comprising culturing a cell of embodiment 231 to make the therapeutic compound.
233. A method of making a nucleic acid sequence encoding the polypeptide of any one of embodiments 1-67 or the molecule of any one of embodiments 68-219, comprising [0688] a) providing a vector comprising sequence encoding a polypeptide having protease activity and inserting into the vector sequence encoding a variant Fc molecule to form an amino acid sequence encoding the polypeptide; or [0689] b) providing a vector comprising sequence encoding a variant Fc molecule and inserting into the vector sequence encoding a polypeptide having protease activity to form an amino acid sequence encoding the polypeptide, thereby making an amino acid sequence encoding the polypeptide.
234. A polypeptide comprising an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 1303, provided that the polypeptide comprises a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, as compared to SEQ ID NO: 35.
235. The polypeptide of embodiment 1, wherein the polypeptide comprises a cysteine (C) at position 94; and/or has, at the positions in said variant sequence which correspond to positions 84, 262, 284 and 286 of SEQ ID NO: 35, a lysine (K), a histidine (H), an aspartic acid (D) and/or an aspartic acid (D), respectively.
236. The polypeptide of embodiment 235, wherein the polypeptide further comprises: [0690] a positively charged amino acid at a position 130, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and/or [0691] a positively charged amino acid at a position 131, optionally wherein said positively charged amino acid is arginine (R) or lysine (K).
237. The polypeptide of embodiment 235, wherein the polypeptide has protease activity.
238. The polypeptide of embodiment 237, wherein the polypeptide has IgG cleaving protease activity.
239. The polypeptide of embodiment 235, wherein the polypeptide is less immunogenic than a wild-type IdeS.
240. The polypeptide of any one of the preceding embodiments, wherein the polypeptide comprises an amino acid sequence of SEQ ID NO: 1303.
241. The polypeptide of embodiment 240, wherein the polypeptide is covalently or non-covalently conjugated to an Fc polypeptide.
242. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide comprises an amino acid sequence having at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to SEQ ID NO: 23.
243. The polypeptide of embodiment 242, wherein the Fc polypeptide comprises an amino acid sequence of SEQ ID NO: 23.
244. The polypeptide of embodiment 241, wherein the polypeptide is covalently or non-covalently conjugated to the N-terminus, or the C-terminus of the Fc polypeptide via a linker.
245. The polypeptide of embodiment 244, wherein the peptide linker is a peptide linker.
246. The polypeptide of embodiment 241, wherein the polypeptide comprises an amino acid sequence of SEQ ID NO: 1318.
247. The polypeptide of embodiment 241, wherein the Fc polypeptide self-associates to form a dimer.
248. A polypeptide comprising an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 1290, 1291, 1292, 1293, 1294, 1295, 1296, 1297, 1298, 1299, 1300, 1301, 1302, 1304, 1305, 1306, 1307, 1308, 1309, 1310, and 1333, provided that the polypeptide comprises any one of, or any combination of, a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, an asparagine (N) at position 286, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and glutamine (Q) at position 336, as compared to SEQ ID NO: 35.
249. The polypeptide of embodiment 248, wherein the polypeptide comprises any one set selected from: [0692] a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; [0693] a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 258, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; [0694] a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, an asparagine (N) at position 286, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336, as compared to SEQ ID NO: 35; [0695] a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, as compared to SEQ ID NO: 35; or [0696] a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, a glutamic acid (E) at position 115, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a lysine (K) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, an isoleucine (I) at position 334, and a glutamine (Q) at position 336 as compared to SEQ ID NO: 35.
250. The polypeptide of embodiment 248, wherein the polypeptide comprises a cysteine (C) at position 94; and/or has, at the positions in said variant sequence which correspond to positions 84, 262, 284 and 286 of SEQ ID NO: 35, a lysine (K), a histidine (H), an aspartic acid (D) and/or an aspartic acid (D), respectively.
251. The polypeptide of embodiment 250, wherein the polypeptide further comprises: [0697] a positively charged amino acid at a position 130, optionally wherein said positively charged amino acid is arginine (R) or lysine (K); and/or [0698] a positively charged amino acid at a position 131, optionally wherein said positively charged amino acid is arginine (R) or lysine (K).
252. The polypeptide of embodiment 248, wherein the polypeptide has protease activity.
253. The polypeptide of any one of the preceding embodiments, wherein the polypeptide has IgG cleaving protease activity.
254. The polypeptide of any one of the preceding embodiments, wherein the polypeptide is less immunogenic than a wild-type IdeS.
255. The polypeptide of any one of the preceding embodiments, wherein the polypeptide comprises an amino acid sequence of SEQ ID NO: 1290, 1291, 1292, 1293, 1294, 1295, 1296, 1297, 1298, 1299, 1300, 1301, 1302, 1304, 1305, 1306, 1307, 1308, 1309, 1310, and 1333.
256. The polypeptide of any one of the preceding embodiments, wherein the polypeptide is covalently or non-covalently conjugated to an Fc polypeptide.
257. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide comprises an amino acid sequence having at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
258. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide comprises an amino acid sequence of any one of SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
259. The polypeptide of any one of the preceding embodiments, wherein the polypeptide is covalently or non-covalently conjugated to the N-terminus, or the C-terminus of the Fc polypeptide via a linker.
260. The polypeptide of any one of the preceding embodiments, wherein the peptide linker is a peptide linker.
261. The polypeptide of any one of the preceding embodiments, wherein the polypeptide comprises, from N-terminus to C-terminus: [0699] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1290; [0700] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1291; [0701] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1292; [0702] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1293; [0703] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1294; [0704] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1295; [0705] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1296; [0706] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1297; [0707] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1298; [0708] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1299; [0709] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1300; [0710] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1301; [0711] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1302; [0712] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1304; [0713] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1305; [0714] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1306; [0715] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1307; [0716] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1308; [0717] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1309; [0718] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1310; [0719] the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23, and the polypeptide having an amino acid sequence of SEQ ID NO: 1333; [0720] the polypeptide having an amino acid sequence of SEQ ID NO: 1290, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0721] the polypeptide having an amino acid sequence of SEQ ID NO: 1291, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0722] the polypeptide having an amino acid sequence of SEQ ID NO: 1292, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0723] the polypeptide having an amino acid sequence of SEQ ID NO: 1293, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0724] the polypeptide having an amino acid sequence of SEQ ID NO: 1294, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0725] the polypeptide having an amino acid sequence of SEQ ID NO: 1295, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0726] the polypeptide having an amino acid sequence of SEQ ID NO: 1296, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0727] the polypeptide having an amino acid sequence of SEQ ID NO: 1297, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0728] the polypeptide having an amino acid sequence of SEQ ID NO: 1298, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0729] the polypeptide having an amino acid sequence of SEQ ID NO: 1299, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0730] the polypeptide having an amino acid sequence of SEQ ID NO: 1300, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0731] the polypeptide having an amino acid sequence of SEQ ID NO: 1301, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0732] the polypeptide having an amino acid sequence of SEQ ID NO: 1302, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0733] the polypeptide having an amino acid sequence of SEQ ID NO: 1304, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0734] the polypeptide having an amino acid sequence of SEQ ID NO: 1305, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0735] the polypeptide having an amino acid sequence of SEQ ID NO: 1306, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0736] the polypeptide having an amino acid sequence of SEQ ID NO: 1307, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0737] the polypeptide having an amino acid sequence of SEQ ID NO: 1308, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0738] the polypeptide having an amino acid sequence of SEQ ID NO: 1309, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; [0739] the polypeptide having an amino acid sequence of SEQ ID NO: 1310, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23; or [0740] the polypeptide having an amino acid sequence of SEQ ID NO: 1333, and the Fc polypeptide having an amino acid sequence of SEQ ID NO: 23.
262. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide self-associates to form a dimer.
263. The polypeptide of any one of the preceding embodiments, wherein the dimer is a homodimer or a heterodimer.
264. The polypeptide of any one of the preceding embodiments, wherein the polypeptide comprises an amino acid sequence of SEQ ID NO: 1311, 1312, 1313, 1314, 1315, 1316, 1317, 1319, 1320, 1321, 1322, 1323, 1324, 1325, 1326, 1327, 1328, 1329, 1334, 1335, and 1336.
265. A polypeptide comprising an amino acid sequence having at least 50%, at least 60%, at least 70%, at least 80%, at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 55-1019.
266. The polypeptide of embodiment 265, wherein the polypeptide is a polypeptide having protease activity.
267. The polypeptide of embodiment 266, wherein the polypeptide has IgG cleaving protease activity.
268. The polypeptide of any one of the preceding embodiments, wherein the polypeptide comprises the amino acid sequence of any one of SEQ ID NO: 55-1019.
269. The polypeptide of any one of the preceding embodiments, wherein the polypeptide is covalently or non-covalently conjugated to an Fc polypeptide.
270. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide comprises an amino acid sequence having at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% sequence identity to any one of SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
271. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide comprises an amino acid sequence of any one of SEQ ID NO: 19, 20, 21, 22, 23, 24, or 25.
272. The polypeptide of any one of the preceding embodiments, wherein the polypeptide is covalently or non-covalently conjugated to the N-terminus, or the C-terminus of the Fc polypeptide via a linker.
273. The polypeptide of any one of the preceding embodiments, wherein the peptide linker is a peptide linker.
274. The polypeptide of any one of the preceding embodiments, wherein the Fc polypeptide self-associates, or associates with another Fc polypeptide, to form a dimer.
275. The polypeptide of any one of the preceding embodiments, wherein the dimer is a homodimer or a heterodimer.
276. The polypeptide of any one of the preceding embodiments, wherein the polypeptide comprises an amino acid sequence of SEQ ID NO: 1023-1289.
277. A pharmaceutical composition comprising the polypeptide of any one of the preceding embodiments.
278. A method of treating a disease or disorder in a subject, the method comprising administering the polypeptide of any one of the preceding embodiments, or the pharmaceutical composition of embodiment 277, to the subject to treat the disease or disorder.
279. The method of embodiment 278, wherein the disease or disorder is selected from Addison's disease, Anti-GBM glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated vasculitides, ANCA associated vasculitis, granulomatous polyangiitis (Wegener granulomatosis), eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), microscopic polyangiitis, anti-NMDAR encephalitis, anti-phospholipid antibody syndrome (APS) and catastrophic APS, autoimmune bullous skin diseases, pemphigus, pemphigus foliaceus (PF), fogo selvage (FS), pemphigus vulgaris (PV), autoimmune hemolytic anemia (AIHA), autoimmune hepatitis (AIH), autoimmune neutropenia (AIN), bullous pemphigoid (BP), Celiac's disease, chronic urticaria, complete congenital heart block (CCHB), diabetes type 1A (T1DM), epidermolysis bullosa acquisita (EBA), essential mixed cryoglobulinemia, Goodpasture's syndrome, anti-glomerular basement membrane disease, Graves' disease, Goitre, hyperthyroidism, infiltrative exophthalmos, infiltrative dermopathy, Guillain-Barre syndrome (GBS), acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), hemophilia, acquired FVII deficiency, idiopathic thrombocytopenic purpura (ITP), Lambert-Eaton myasthenic syndrome (LEMS), mixed connective tissue disease (MCTD), multiple myeloma, myasthenia gravis, myasthenic crisis, myocarditis, dilated cardiomyopathy (DCM), congestive cardiomyopathy, neuromyelitis optica (NMO), primary biliary cirrhosis (PBC), primary progressive multiple sclerosis (PPMS), relapsing-rheumatic multiple sclerosis, acute exacerbation of multiple sclerosis, rheumatic heart disease (RHD), rheumatoid arthritis (RA), serum-sickness, immune complex hypersensitivity (type III), Sj?gren's syndrome (SS), lupus nephritis, systemic lupus erythematosus (SLE), cutaneous lupus (CLE), transplant rejection, thrombotic thrombocytopenic purpura (TTP), idiopathic inflammatory myopathies, polymyositis, dermatomyositis, inclusion body myositis, uveitis, scleritis, ankylosing spondylitis, axial spondyloarthritis, reactive arthritis, psoriatic arthritis, IBD-associated arthritis, antiphospholipid syndrome, systemic sclerosis, giant cell arteritis, polymyalgia rheumatic, Takayasu's arteritis, anti-neutrophil cytoplasmic antibody associated vasculitis, Henoch-Schonlein purpura, polyarteritis nodosa, Cogan's syndrome, Buerger's disease, Susan's disease, immune complex vasculitis, primary angiitis of the central nervous system (CNS), Behcet's disease, relapsing polychondritis, juvenile idiopathic arthritis, juvenile dermatomyositis, autoimmune brain disease, sarcoidosis, neurosarcoidosis, IgG4-related diseases, autoimmune complications of immune checkpoint inhibitors (IRAEs), adult onset Still's disease, warm antibody hemolytic anemia (wAIHA), immune thrombocytopenia, immune thrombotic thrombocytopenia, thrombic thrombocytopenia, pernicious anemia, aplastic anemia, Evan's syndrome, autoimmune neutropenia, acquired von Willibrand syndrome, recurring fetal loss, Rh mismatch, ulcerative colitis, autoimmune hepatitis, autoimmune pancreatitis, eosinophilic esophagitis/gastritis, primary sclerosing cholangitis, primary biliary sclerosis, glomerulonephritis, glomerular basement membrane disease, scleritis/episcleritis, uveitis, conjunctivitis, keratitis, type I diabetes mellitus, Hashimoto's thyroiditis, polyglandular autoimmune endocrine syndromes, atopic dermatitis, dermatitis herpetiformis, pemphigus foliaceus, fogo selvagem, cutaneous lupus erythematosus, linear IgA disease, Lichen planus, transplantation, antibody-mediated rejection, alloantibody hypersensitization, xenoantibody mediated rejection, solid organ rejection, graft vs. host disease (GVHD), multiple sclerosis, neuromyelitis optica, amyotrophic lateral sclerosis, Parkinson's disease, autoimmune encephalitis, CNS vasculitis, chronic idiopathic demyletinating polyneuropathy, transverse myelitis, optic neuritis, anti-myelin oligodendrocyte glycoprotein (MOG) disease, chronic meningitis, rheumatic heart disease, infectious disease, vaccination, antibody dependent enhancement, antibody to therapeutic biologic agents (cytokines, monoclonal antibodies, enzymes, coagulation factors), allergic asthma, eosinophilic pneumonia, nonspecific interstitial pneumonia, rheumatoid arthritis-associated interstitial lung disease (RA-ILD), sarcoidosis, hypersensitive pneumonitis, allergic bronchopulmonary mycosis, chronic rhinosinusitis with nasal polyps, or any combination thereof.
280. A method of treating a transplant subject comprising administering a therapeutically effective amount of the polypeptide of any one of the preceding embodiments, or the pharmaceutical composition of embodiment 277, to the subject, thereby treating the transplant (recipient) subject.
281. A method of improving a gene-therapy in subject comprising administering a therapeutically effective amount of the polypeptide of any one of the preceding embodiments, or the pharmaceutical composition of embodiment 277, to the subject, thereby improving the gene-therapy in the subject.
282. A method of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder, comprising administering a therapeutically effective amount of the polypeptide of any one of the preceding embodiments, or the pharmaceutical composition of embodiment 277, thereby treating the subject.
283. A method of cleaving B cell receptor, the method comprising administering a therapeutically effective amount of the polypeptide of any one of the preceding embodiments, or the pharmaceutical composition of embodiment 277, to cleave the B cell receptor.
284. A polypeptide comprising an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a polypeptide comprising the amino acid sequence of SEQ ID NO: 36 or 1349, provided that the polypeptide comprises one or more of, or all of the following: a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, wherein the positions correspond to the positions as in SEQ ID NO: 35.
285. The polypeptide of embodiment 284, wherein the polypeptide does not comprises the amino acid sequence of DSFSANQEIRYSEVTPYHVT (SEQ ID NO: 1351).
286. The polypeptide of embodiment 284, wherein the polypeptide does not comprises the amino acid sequence of DSFSANQEIRYSEVTPYH (SEQ ID NO: 1352).
287. The polypeptide of embodiment 284, wherein the polypeptide does not comprises the amino acid sequence of ANQEIRYSEVTPYHVT (SEQ ID NO: 1353).
288. The polypeptide of embodiment 284, wherein the polypeptide does not comprises the amino acid sequence of ANQEIRYSEVTPYH (SEQ ID NO: 1354).
289. The polypeptide of any one of embodiments 284-288, wherein the polypeptide does not comprise the amino acid sequence of NQTN (SEQ ID NO: 1355).
290. The polypeptide of any one of embodiments 284-289, wherein the polypeptide comprises the sequence of QQTN (SEQ ID NO: 1356) at the C-terminus of the polypeptide instead of the sequence of NQTN (SEQ ID NO: 1355).
291. The polypeptide of any one of embodiments, 284-290, wherein the polypeptide has a cysteine (C) at the position in said polypeptide which corresponds to position 94 of SEQ ID NO: 35.
292. The polypeptide of any one of embodiments, 284-291, wherein the polypeptide In some embodiments, the polypeptide has, at the positions in said variant sequence which correspond to positions 84, 262, 284 and 286 of SEQ ID NO: 35, a lysine (K), a histidine (H), an aspartic acid (D) and an aspartic acid (D), respectively.
293. The polypeptide of any one of embodiments, 284-292, wherein the polypeptide has a positively charged amino acid at the position in said variant which corresponds to position 130 of SEQ ID NO: 35, such as, arginine (R) or lysine (K).
294. The polypeptide of any one of embodiments, 284-293, wherein the polypeptide has a positively charged amino acid at the position in said variant which corresponds to position 131 of SEQ ID NO: 35, such as arginine (R) or lysine (K).
295. The polypeptide of any one of embodiments, 284-294, wherein the polypeptide has at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90% identity to the polypeptide of SEQ ID NO: 35 or SEQ ID NO: 1349.
296. The polypeptide of any one of embodiments of 284-294, wherein the polypeptide comprises a threonine (T) at position 60, an aspartic acid (D) at position 61, an isoleucine (I) at position 63, a tyrosine (Y) at position 64, a leucine (L) at position 69, a lysine (K) at position 74, a glycine (G) at position 76, a leucine (L) at position 85, a glutamic acid (E) at position 112, an asparagine (N) at position 116, a lysine (K) at position 119, a lysine (K) at position 120, a tyrosine (Y) at position 121, a glycine (G) at position 130, a leucine (L) at position 134, an aspartic acid (D) at position 145, a serine (S) at position 146, an aspartic acid (D) at position 154, an aspartic acid (D) at position 190, an arginine (R) at position 198, an asparagine (N) at position 223, a tyrosine (Y) at position 225, a leucine (L) at position 227, a threonine (T) at position 231, a glutamine (Q) at position 241, an isoleucine (I) at position 251, a glycine (G) at position 261, an alanine (A) at position 273, a glutamic acid (E) at position 274, a glutamic acid (E) at position 278, a proline (P) at position 289, a serine (S) at position 303, a glutamic acid (E) at position 314, and an isoleucine (I) at position 334, wherein the positions correspond to the positions as in SEQ ID NO: 35.
297. The polypeptide of any one of embodiments of 284-296, wherein polypeptide is linked to a protease resistant Fc domain.
298. The polypeptide of embodiment 297, wherein the protease resistant Fc domain is linked to the N-terminus or the C-terminus of the polypeptide of any one of embodiments 284-296.
299. The polypeptide of embodiment 298, wherein the protease resistant Fc domain is linked to the N-terminus of the polypeptide of any one of embodiments 284-296.
300. The polypeptide of any one of embodiments 297-299, wherein the protease resistant Fc domain is linked to the polypeptide of any one of embodiments 284-296 through a peptide linker, such as, but not limited to, those provided for herein.
301. The polypeptide of embodiment 300, wherein the peptide linker comprises the amino acid sequence of SEQ ID NO: 1330.
302. The polypeptide of any one of embodiments 297-301, wherein the protease resistant Fc domain is as provided for herein.
303. The polypeptide of any one of embodiments 297-302, wherein the protease resistant Fc domain comprises the amino acid sequence of any one of SEQ ID NOs: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49.
304. The polypeptide of any one of embodiments 297-303, wherein the protease resistant Fc domain comprises the amino acid sequence of SEQ ID NO: 23.
305. The polypeptide of any one of embodiments 297-304, wherein the polypeptide comprises a polypeptide from N-terminus to C-terminus a protease resistant Fc domain, a peptide linker, and a polypeptide of any one of embodiments 284-296, wherein the C-terminus of the protease resistant Fc domain is linked to the N-terminus of the peptide linker and the C-terminus of the peptide linker is linked to the N-terminus of the polypeptide of any one of embodiments 284-296.
306. The polypeptide of embodiment 305, wherein the polypeptide comprises the amino acid sequence as set forth in Table 7 in the column labeled Full length sequence of VRT-1 through VRT-319.
307. The polypeptide of any one of embodiments of 284-306, wherein the polypeptide has Ig protease activity, such as IgG protease activity.
308. The polypeptide of any one of embodiments 284-307, wherein the polypeptide is less immunogenic than an IdeS polypeptide, wherein the IdeS polypeptide optionally comprises the amino acid sequence of SEQ ID NO: 35, SEQ ID NO: 36 or SEQ ID NO: 1349.
309. The polypeptide of any one of embodiments 284-308, wherein the polypeptide produces greater quantity of IgG cleavage fragments than IdeS (e.g., SEQ ID NO: 35, SEQ ID NO: 36, or SEQ ID NO: 1349).
310. A pharmaceutical composition comprising the polypeptide of any one of embodiments 284-309.
311. The pharmaceutical composition of embodiment 310, wherein the composition comprises a dimer comprising a first polypeptide comprising the polypeptide of any one of embodiments 284-309 and a second polypeptide comprising the polypeptide of any one of embodiments 284-309, wherein the first polypeptide and the second polypeptide are the same.
312. The pharmaceutical composition of embodiment 310, wherein the composition comprises a dimer comprising a first polypeptide comprising the polypeptide of any one of embodiments 284-296 linked to a first protease resistant Fc domain, and a second polypeptide comprising the polypeptide of any one of embodiments 284-296 linked to a second protease resistant Fc domain, wherein the first polypeptide and the second polypeptide are the same.
313. The pharmaceutical composition of embodiment 312, wherein the first protease resistant Fc domain and the second protease resistant Fc domain comprise the same amino acid sequence.
314. The pharmaceutical composition of embodiment 312, wherein the first protease resistant Fc domain and the second protease resistant Fc domain comprise different amino acid sequences, provided that the first and second Fc domains can form a dimer.
315. The pharmaceutical composition of any one of embodiments 312-314, wherein first and second protease resistant Fc domains comprise, independently, the amino acid sequence of any one of SEQ ID NOs: 19, 20, 21, 22, 23, 24, 25, 42, 43, 44, 45, 46, 47, 48, or 49.
316. The pharmaceutical composition of embodiment 313, wherein the protease resistant Fc domain comprises the amino acid sequence of SEQ ID NO: 23.
317. The polypeptide or pharmaceutical composition of any one of embodiments 297-316, wherein the protease resistant Fc domain is resistant to cleavage by an IdeS protease, or variant thereof, such as a polypeptide of any one of embodiments of 284-296.
318. A method of reducing immunoglobulins, such as IgG, in a subject, the method comprising administering to the subject a polypeptide or composition of any one of embodiments 284-317.
319. A method of treating a disease or disorder in a subject, the method comprising administering to the subject a polypeptide or composition of any one of embodiments 284-317 to treat the disease or disorder.
320. The method of embodiment 319, wherein the disease or disorder is selected from Addison's disease, Anti-GBM glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated vasculitides, ANCA associated vasculitis, granulomatous polyangiitis (Wegener granulomatosis), eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), microscopic polyangiitis, anti-NMDAR encephalitis, anti-phospholipid antibody syndrome (APS) and catastrophic APS, autoimmune bullous skin diseases, pemphigus, pemphigus foliaceus (PF), fogo selvage (FS), pemphigus vulgaris (PV), autoimmune hemolytic anemia (AIHA), autoimmune hepatitis (AIH), autoimmune neutropenia (AIN), bullous pemphigoid (BP), Celiac's disease, chronic urticaria, complete congenital heart block (CCHB), diabetes type 1A (T1DM), epidermolysis bullosa acquisita (EBA), essential mixed cryoglobulinemia, Goodpasture's syndrome, anti-glomerular basement membrane disease, Graves' disease, Goitre, hyperthyroidism, infiltrative exophthalmos, infiltrative dermopathy, Guillain-Barre syndrome (GBS), acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), hemophilia, acquired FVII deficiency, idiopathic thrombocytopenic purpura (ITP), Lambert-Eaton myasthenic syndrome (LEMS), mixed connective tissue disease (MCTD), multiple myeloma, myasthenia gravis, myasthenic crisis, myocarditis, dilated cardiomyopathy (DCM), congestive cardiomyopathy, neuromyelitis optica (NMO), primary biliary cirrhosis (PBC), primary progressive multiple sclerosis (PPMS), relapsing-rheumatic multiple sclerosis, acute exacerbation of multiple sclerosis, rheumatic heart disease (RHD), rheumatoid arthritis (RA), serum-sickness, immune complex hypersensitivity (type III), Sj?gren's syndrome (SS), lupus nephritis, systemic lupus erythematosus (SLE), cutaneous lupus (CLE), transplant rejection, thrombotic thrombocytopenic purpura (TTP), idiopathic inflammatory myopathies, polymyositis, dermatomyositis, inclusion body myositis, uveitis, scleritis, ankylosing spondylitis, axial spondyloarthritis, reactive arthritis, psoriatic arthritis, IBD-associated arthritis, antiphospholipid syndrome, systemic sclerosis, giant cell arteritis, polymyalgia rheumatic, Takayasu's arteritis, anti-neutrophil cytoplasmic antibody associated vasculitis, Henoch-Schonlein purpura, polyarteritis nodosa, Cogan's syndrome, Buerger's disease, Susan's disease, immune complex vasculitis, primary angiitis of the central nervous system (CNS), Behcet's disease, relapsing polychondritis, juvenile idiopathic arthritis, juvenile dermatomyositis, autoimmune brain disease, sarcoidosis, neurosarcoidosis, IgG4-related diseases, autoimmune complications of immune checkpoint inhibitors (IRAEs), adult onset Still's disease, warm antibody hemolytic anemia (wAIHA), immune thrombocytopenia, immune thrombotic thrombocytopenia, thrombic thrombocytopenia, pernicious anemia, aplastic anemia, Evan's syndrome, autoimmune neutropenia, acquired von Willibrand syndrome, recurring fetal loss, Rh mismatch, ulcerative colitis, autoimmune hepatitis, autoimmune pancreatitis, eosinophilic esophagitis/gastritis, primary sclerosing cholangitis, primary biliary sclerosis, glomerulonephritis, glomerular basement membrane disease, scleritis/episcleritis, uveitis, conjunctivitis, keratitis, type I diabetes mellitus, Hashimoto's thyroiditis, polyglandular autoimmune endocrine syndromes, atopic dermatitis, dermatitis herpetiformis, pemphigus foliaceus, fogo selvagem, cutaneous lupus erythematosus, linear IgA disease, Lichen planus, transplantation, antibody-mediated rejection, alloantibody hypersensitization, xenoantibody mediated rejection, solid organ rejection, graft vs. host disease (GVHD), multiple sclerosis, neuromyelitis optica, amyotrophic lateral sclerosis, Parkinson's disease, autoimmune encephalitis, CNS vasculitis, chronic idiopathic demyletinating polyneuropathy, transverse myelitis, optic neuritis, anti-myelin oligodendrocyte glycoprotein (MOG) disease, chronic meningitis, rheumatic heart disease, infectious disease, vaccination, antibody dependent enhancement, antibody to therapeutic biologic agents (cytokines, monoclonal antibodies, enzymes, coagulation factors), allergic asthma, eosinophilic pneumonia, nonspecific interstitial pneumonia, rheumatoid arthritis-associated interstitial lung disease (RA-ILD), sarcoidosis, hypersensitive pneumonitis, allergic bronchopulmonary mycosis, chronic rhinosinusitis with nasal polyps, or any combination thereof.
321. A method of treating a transplant subject comprising administering to the subject a therapeutically effective amount of a polypeptide or composition of any one of embodiments 284-317, thereby treating the transplant (recipient) subject.
322. A method of improving a gene-therapy in subject comprising administering to the subject a therapeutically effective amount a polypeptide or composition of any one of embodiments 284-317, prior to, after, or simultaneously with the gene therapy, thereby improving the gene-therapy in the subject.
323. A method of treating a subject having, or at risk, or elevated risk, for having, an IgG mediated disease or disorder, comprising administering to the subject a therapeutically effective amount of a polypeptide or composition of any one of embodiments 284-317.
324. A method of cleaving B cell receptor in a subject, the method comprising administering to the subject a therapeutically effective amount of a polypeptide or composition of any one of embodiments 284-317 to cleave the B cell receptor.

[0741] The following examples are illustrative, but not limiting, of the compounds, compositions and methods described herein. Other suitable modifications and adaptations known to those skilled in the art are within the scope of the following embodiments.

EXAMPLES

Example 1: Ides-Fc Polypeptides Exhibit High Yield in a Mammalian Expression System

[0742] IdeS-Fc polypeptides provided herein were transiently expressed in Expi293 cells. Volumes of 2-5 ul of the supernatants were loaded onto SDS-PAGE or CE-SDS gels to visualize the bands of target proteins. All fusion formats had yields in excess of 100 mg/L. Homo-dimeric formats, including IdeS-Fc, Fc-IdeS, VHH(nanobody)-IdeS-Fc, and Fc-IdeS-VHH(nanobody), had approximately 500 mg/L yield. Knob-in-hole Fc formats produced mixture of correct paired and mis-paired species.

Example 2: Ides-Fc Polypeptides from Mammalian Expression were Catalytically Active Against Human IgG1

[0743] IdeS-Fc polypeptides provided herein were transiently expressed in Expi293 cells. Supernatants were incubated with a substrate human IgG1 kappa monoclonal antibody. Samples were loaded onto an SDS-PAGE gel to assess whether IgG1 was cleaved. All fusion formats, except the heavily glycosylated VRT-20, were catalytically active. IdeS with glycosylation knock out mutation at N61 remained active. VRT-20 was engineered to have 9 additional glycosylation sites comparing to wild type IdeS. Thus, the glycan shield blocked its activity.

Example 3: Ides-Fc Polypeptides Exhibit Aggregation in Low pH Elution from ProA Resin Columns

[0744] Supernatants of Ides-Fc polypeptides from Expi293 expression were loaded onto protein A resin (ProA). Resin was eluted with low pH buffer at pH 2.8-3.3. ProA elution was neutralized with 1M Tris pH 8. Neutralized samples were spun down and the supernatant was loaded onto a 24 mL Superdex 75 size exclusion column. IdeS-Fc polypeptides precipitated heavily during low pH elution from protein A column. The protein A eluates were mainly aggregates on size exclusion column.

[0745] In another experiment, 5 mL of supernatants of Ides-Fc polypeptides from Expi293 expression were loaded onto protein A column. Column was eluted with low pH buffer at pH of 2.8-3.3. ProA elution was neutralized with 1M Tris pH 8. Precipitates were spun down and pellets were resuspended for SDS-PAGE. Neutralized samples were run on a SDS-PAGE gel. Inter-molecule disulfide bonds, were observed in the protein A elution fractions. The resuspended precipitates had primarily inter-molecule disulfide linked species.

Example 4: Addition of Arginine and 2-MEA to the Elution Buffer Prevents Precipitation During ProA Purification

[0746] Supernatants of Ides-Fc polypeptides from Expi293 expression were loaded onto protein A resin (ProA). Resin was eluted with low pH buffer at pH 2.8-3.3, as well as with and without arginine and 2-mercaptoethylamine. ProA elution was neutralized with 1M Tris pH 8. Neutralized samples were spun down and the supernatant was loaded onto a 24 mL Superdex 75 size exclusion column. No precipitation of IdeS-Fc polypeptides was observed when arginine and 2-mercaptoethylamine were included in low pH protein A elution buffer. Eluates arginine and 2-mercaptoethylamine produced more monomeric species on size exclusion column than the elutes with only low pH buffer.

Example 5: SEC Purified Ides-Fc Polypeptides with Optimized Purification Process have Similar Activity to IdeS from E. coli

[0747] Purified Ides-Fc polypeptides were subjected to Protein A elution and two step purified. Next, samples were incubated with substrate human monoclonal IgG1 at 1:100 Fc fusion:IgG molar ratio, for 4 hours at 37? C. IdeS purified from E. coli was assessed side by side, using 1:100 and 1:50 IdeS:IgG molar ratio. Digestion samples were loaded onto a CE-SDS gel to separate the bands of intact IgG (substrate), single cut IgG (intermediate product), and F(ab)2 (final product). Intensity of the target bands were used to visualize the data shown in FIG. 1. Two step purified IdeS-Fc polypeptides displayed similar activity to IdeS alone produced from E. coli.

Example 6: Low pH Destabilization of IdeS and IdeS-Fc Polypeptides

[0748] Ni-NTA one step purified IdeS and Ides-Fc polypeptides were incubated with different buffers, covering pH range 2.8 to 8. Thermostability and turbidity were measured at temperatures ranging from 25? C. to 90? C. At pH 2.8 to pH 4.5, no phase transition from folded to unfolded was observed on IdeS and IdeS-Fc fusion protein. This indicates the polypeptides were destabilized by low pH. At pH above 6, clear phase transition from folded to unfolded was observed on IdeS and IdeS-Fc fusion protein, with Tm around 50-55? C. This indicates the polypeptides were stable between pH 6 and pH 8.

Example 7: Screening of Excipients Identified Chemicals that Increase Ides-Fc Polypeptide Thermostability

[0749] Two step purified Ides-Fc polypeptide VRT-5 was incubated with chemicals from two 96 well screening kits (HR2-072 and HR2-413 from Hampton Research). Thermostability and turbidity of each condition were measured at temperatures ranging from 25? C. to 90? C. As shown in the tables below, certain chemicals and buffers were identified to increase thermostability (Tm and Tagg). VRT-5 was more stable at neutral and basic pH, in pH range 4.5 to 9. VRT-5 was more stable at higher sodium chloride concentration in range of 0.05 to 1M. Top 3 chemicals that increased Tm were D-sorbitol, Sucrose, and sodium sulfate. Succinic acid, sodium malonate, DL-malic acid also increased Tm at pH 7.0. Combination of D-sorbitol, Sucrose, and sodium sulfate in one buffer produced synergistic increase of thermo stability.

TABLE-US-00019 Tm Tagg Conditions (? C.) (? C.) 0.05M Sodium acetate trihydrate pH 4.5, 34.98 65.25 1M Sodium chloride 0.05M Sodium citrate tribasic dihydrate pH 5.0, 50.38 81.01 1M Sodium chloride 0.05M Succinic acid pH 5.5, 52.83 82.31 1M Sodium chloride 0.05M MES monohydrate pH 6.0, 49.23 78.28 1M Sodium chloride 0.05M BIS-TRIS pH 6.5, 52.70 81.80 1M Sodium chloride 0.05M Imidazole pH 7.0, 53.29 81.93 1M Sodium chloride 0.05M HEPES pH 7.5, 54.57 83.41 1M Sodium chloride 0.05M Tris pH 8.0, 54.12 83.39 1M Sodium chloride 0.05M BIS-TRIS Propane pH 8.5, 53.94 83.72 1M Sodium chloride 0.05M AMPD pH 9.0, 53.26 83.03 1M Sodium chloride 0.05M Glycine pH 9.5, 53.41 83.48 1M Sodium chloride

[0750] Thermostability of VRT-5 increased as NaCl concentration increased.

TABLE-US-00020 Tagg Tagg Conditions (? C.) (? C.) Water 48.76 56.74 0.05M NaCl 51.05 70.25 0.1M NaCl 51.82 72.05 0.15M NaCl 52.24 77.97 0.2M NaCl 52.35 78.98 0.25M NaCl 52.59 80.17 0.5M NaCl 53.42 81.91 1M NaCl 54.34 83.31

[0751] Thermostability of VRT-5 increased when the chemicals provided in the table below were included in solution.

TABLE-US-00021 Tm Tagg Conditions in water (? C.) (? C.) Water 48.76 56.74 1M D-sorbitol 53.37 77.07 1M sucrose 54.32 82.72 0.5M sodium sulfate decahydrate 55.45 55.09 0.5M NaCl 53.44 81.80 0.25M sodium malonate pH 7.0 54.35 54.65 0.25M succinic acid pH 7.0 54.71 54.49 0.25M DL-malic acid pH 7.0 54.87 54.73 0.375M D-(+)-Trehalose dihydrate 51.48 56.74 1.25M Betaine monohydrate 52.35 73.38 1M Xylitol 52.41 82.37 2.5% v/v Tacsimate pH 7.0 52.70 75.57 25% v/v Glycerol 52.77 58.48 1.25M Trimethylamine N-oxide dihydrate 54.00 84.17

[0752] Combination of D-sorbitol, Sucrose, and sodium sulfate in one buffer produced synergistic increase of thermo stability.

TABLE-US-00022 Conditions Excipients Tm (? C.) Tagg (? C.) Water control None 47.24 56.43 pH 3.5 Glycine 50 mM, 166 mM NaCl NaCl 51.76 73.15 pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + D-sorbitol 53.08 80.92 350 mM D-sorbitol pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + sodium sulfate 53.17 79.79 175 mM sodium sulfate decahydrate decahydrate pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + sucrose 53.87 84.00 350 mM sucrose pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + D-sorbitol + 54.96 85.29 350 mM D-sorbitol, 350 mM sucrose sucrose pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + D-sorbitol + 55.06 83.27 350 mM D-sorbitol, 175 mM sodium sulfate sodium sulfate decahydrate decahydrate pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + sucrose + 55.44 85.22 350 mM sucrose, 175 mM sodium sulfate sodium sulfate decahydrate decahydrate pH 3.5 Glycine 50 mM, 166 mM NaCl, NaCl + D-sorbitol + 56.94 Too 350 mM D-sorbitol, 350 mM sucrose, sucrose + sodium close to 90? C. 175 mM sodium sulfate decahydrate sulfate decahydrate to be measured

Example 8: Fc-IdeS Fusion Molecule Exhibits Extended PK and PD In Vivo

[0753] C57BL/6 mice (n=3/group) were injected with human intravenous immunoglobulin (IVIG) and allowed to equilibrate for 24 hours before being injected with the vehicle, IdeS protease (0.5 mg/kg), or the Fc-IdeS fusion molecule (0.9 mg/kg). Mice were euthanized for blood collection at 0 hours, 0.5 hours, 2 hours, 4 hours, 24 hours, and 48 hours following injection of the vehicle, IdeS, or Fc-IdeS. Plasma was collected for exposure analysis and measurement of human IgG levels. Fc-IdeS exhibited extended PK in mice in the presence of human IgG (FIG. 2A), as compared to IdeS. Fc-IdeS also exhibited improved PD as evidence by improved IVIG cleavage (FIG. 2B).

Example 9: Fc-IdeS Fusion Molecule Remains Active In Vivo for at Least 4 Days

[0754] C57BL/6 mice (n=6 for the vehicle treated mice; and n=3 per group for the Fc-IdeS treated mice) were injected intravenously with 0.9 mg/kg Fc-IdeS, followed by injection of human intravenous immunoglobulin (IVIG) at 0.5 hours, 2 hours, 4 hours, 6 hours, 8 hours, 24 hours, 48 hours, 72 hours, or 96 hours following Fc-IdeS injection. Blood was first collected 15 minutes prior to injection of IVIG for PK determination, and mice were euthanized 2 hours after IVIG injection for PD measurements. Fc-IdeS exhibited extended PK in mice (FIG. 3). PD analysis showed reduced human IgG level even 4 days following injection with Fc-IdeS, illustrating that Fc-IdeS remained active 4 days after injection in mice (FIG. 3).

Example 10: Fc-IdeS Demonstrates Efficacy in an IgG Immune Complex-Mediated Kidney Disease In Vivo Model

[0755] Without wishing to be bound to a particular theory, pathology in the anti-GBM (glomerular basement membrane) mouse model of kidney disease is driven by immune complex deposition in the kidneys. Immune complexes bind to the glomerular basement membrane in the kidney, inducing tissue damage via complement activation, proteinuria and an increase in blood urea nitrogen (BUN). Fc-IdeS was used to treat the disease by cleaving sheep IgG immune complexes prophylactically. In brief, female 129/SvJ mice (n=10 per group) were sensitized by immunization with sheep IgG (IP injection) followed by injection of sheep ant-rat GBM serum (which is cross-reactive to mouse GBM) five days following immunization. At 4 days following immunization, mice were intravenously injected with 8 mg/kg Fc-IdeS, a vehicle, or dexamethasone (dex). Mice were euthanized 15 days following immunization. Plasma PK was measured at days 5 and 15 following immunization. Proteinuria was measured the day before immunization and at days 1, 4, 6, 8, 11, 13, and 15 following immunization. Blood urea nitrogen (BUN) was measured at day 15 following immunization. Additionally, kidney histology was assessed at day 15 following immunization. Prophylactic treatment with Fc-IdeS prevented immune complex-driven proteinuria and increase in blood urea nitrogen (BUN), as shown in FIGS. 4A-4F.

Example 11: Fc-IdeS Demonstrates Ability to Cleave B Cell Receptors

[0756] Whole blood was collected in NA heparin tubes and plated in a 96 well round bottom plate varying doses of Fc-IdeS. Dose ranges from 2000 nM to 0.3 nM. The blood and protease were incubated at 37? C. and 5% CO2 for 20 hours. The blood was lysed and the cells were stained with antibodies for CD20, IgM, IgD, IgG, Kappa and Lambda. Cells were acquired on the attune and analyzed in Flow Jo. Treatment of human whole blood with Fc-IdeS lead to a dose dependent decrease in the expression of kappa and lambda light chains, as shown below and in FIGS. 5A-5B.

TABLE-US-00023 Light chain EC50 Fc-IdeS Kappa 80 nM Lambda 127 nM

Example 12: Characterization of Polypeptides Having Protease Activity and Fusions of Said Polypeptides to Fc Moieties

[0757] Mutant proteases were designed using advanced machine learning based algorithms centered around learning residue epistasis from natural protease sequences to allow for mutagenesis of B cell epitopes, predicted T cell epitopes, predicted chemical liabilities, whilst maintaining enzyme activity and either maintaining or increasing thermostability.

Purification and Quantification of Polypeptides Produced in E. coli

[0758] Gene synthesis and standard cloning techniques were used to create E. coli (pET29b) expression vectors for each of the designed proteases. Vectors were sequence verified by Sanger sequencing prior to transformation. Proteases cloned in pET29b were transformed into E. coli (BL21 Star) using standard procedures. The transformed E. coli were outgrown in SOC media, transferred to LB media overnight to scale up for starter culture that was inoculated into ZYM5052 autoinduction media. Scaled up cultures were incubated with aeration for 4 hrs at 37? C. and then 18 hrs at 20? C. E. coli pellets were harvested by centrifugation and a lysozyme/DNAse mixture used for lysis. Lysate was isolated via centrifugation and then fed into the purification protocol. For E. coli production, after lysing of the bacterial pellet, 25 ?L of the whole cell lysate was collected for analysis. The lysed culture was then spun down for 30 min at 4000 rcf and supernatant was moved to a new plate. 25 ?L of clarified lysate was saved. The clarified lysate was purified with Ni-NTA resin and the eluted protein was buffer exchanged to PBS (pH 7.4). Samples of (1) whole cell lysate, (2) soluble lysate and (3) purified protein were analyzed by CE-SDS, and concentrations were calculated by comparing to a standard dilution of IdeS protease. Expression titer was from the whole cell lysate concentration, and percent soluble was calculated by dividing the (2) soluble lysate concentration by the (1) whole cell lysate concentration. Polypeptides having protease activity exhibited a variety of expression levels ranging from less than, equal to, or more than the parental proteases, as shown in Tables 9, 10, and 11 below.

Expression and Purification of Polypeptides Produced in Mammalian Cells

[0759] Gene synthesis and standard cloning techniques were used to create mammalian (pcDNA3.4) expression vectors for each of the designed Fc fusions. Mammalian expression vectors were transfected into Expi293 or ExpiCHO cells using expifectamine transfection kits from Thermo Scientific following standard manufacturers protocol. Transfection supernatant was clarified by Day 5 after transfection (HEK cells), Day 7 after transfection (CHO cells), or once cell viability dropped to 80-85%, whichever occurred sooner. Clarified supernatant was filtered using a 0.22 ?m filter for sterilization prior to purification. For mammalian cell production, the expression titer was measured directly from the supernatant, with a control antibody as a standard titration. Protease-Fc fusions were purified from the harvested supernatant using protein A based affinity chromatography on an AKTA FPLC. Purified protein was formulated into PBS pH 7.4. Variant protease-Fc fusions exhibited a variety of expression levels ranging from less than, equal to, or more than the parental protease Fc fusion, as shown in Tables 14, 15, and 16 below.

Enzyme Activity Endpoint Assay

[0760] The buffer exchanged protease produced from E. coli was normalized to 0.1 and 0.2 mg/ml. 1 ?L of sample polypeptide having protease activity was mixed with 2 ?L of human IgG1, 2, 3 and 4 (0.4 mg/ml) and incubated at 37? C. for 4 hrs. After 4 hrs, 7 ?L of Sample buffer (containing 8 ?M iodoacetamide) was added with mixing to quench the reaction. Samples were run on CE-SDS. For mammalian produced proteases, 2 ?L of supernatant was used in the endpoint assay. The data shown in Tables 14, 15, and 16 illustrates that many polypeptides having protease activity retained the same level of proteolytic activity as the respective parental proteases, or even exhibited increased activity.

Thermostability Measurements

[0761] From the experimental group comprising 0.2 mg/ml normalized samples, 10 ?L of each sample was loaded into a capillary and Tm was measured by intrinsic nanoDSF using a Prometheus Panta. The analysis identified a number of polypeptides having protease activity with higher Tm than the parental protease, as shown in Tables 14 and 15.

TABLE-US-00024 TABLE 14 Crude Enzyme Activity Endpoint Assay Expression (purified) ng/ul (substrate (LabChip) Yield Purified pooled human IgG) Thermostability Molecule ID ng/uL (mg/L) Fc Fab2 scIgG IgG Tm1 (? C.) huIgG_cntrl1 0 0 0 140 PRT-CNTRL 4 121 127 48 16 14 55 PRT-1 3 63 100 44 21 23 55 PRT-2 3 56 94 47 0 21 52 PRT-3 3 61 72 14 33 11 53 PRT-4 5 36 97 21 42 23 62 PRT-5 4 74 117 34 34 18 57 PRT-6 4 80 129 49 15 16 59 PRT-7 5 145 137 50 16 18 59 PRT-8 5 128 127 50 16 16 57 PRT-9 3 38 103 39 32 21 61 PRT-10 3 68 56 2 58 32 59 PRT-11 4 78 100 40 0 13 58 PRT-12 4 65 122 47 14 16 53 PRT-13 4 93 74 2 66 12 57 PRT-14 3 109 94 18 43 13 52 PRT-15 3 88 136 52 17 18 54 PRT-16 4 97 0 0 0 151 Not determined PRT-17 3 79 116 53 0 34 53 PRT-18 4 97 105 44 11 12 54 PRT-19 5 99 108 42 13 13 53 PRT-20 4 104 124 48 13 15 54 PRT-21 3 87 111 33 28 23 57 PRT-22 4 105 116 37 23 19 58 PRT-23 4 107 125 45 19 12 58 PRT-24 5 117 131 52 16 18 57 PRT-25 3 65 123 56 0 20 57 PRT-26 3 114 101 40 14 11 57 PRT-27 4 94 112 44 13 14 54 PRT-28 4 102 89 16 44 14 54 PRT-29 3 65 95 19 43 27 53 PRT-30 3 128 73 3 65 21 54 PRT-31 3 106 126 46 15 13 55 PRT-32 4 120 124 48 17 14 56 PRT-33 3 83 93 26 44 17 54 PRT-34 3 102 95 37 14 10 56 PRT-35 5 103 104 37 14 9 55 PRT-36 4 127 123 48 16 15 55 PRT-37 3 112 79 4 69 23 55 PRT-38 3 111 124 46 15 14 54 PRT-39 5 121 116 39 19 9 54 PRT-40 4 110 108 42 13 14 53 PRT-41 4 71 94 24 50 19 55 PRT-42 3 72 54 0 53 26 55 PRT-43 6 90 89 23 32 13 56 PRT-44 4 95 78 3 60 14 49 PRT-45 4 114 76 3 67 8 52 PRT-46 3 137 101 20 39 15 50 PRT-47 5 131 5 0 0 132 52 PRT-48 4 73 5 0 0 141 46 PRT-49 1 99 96 30 40 18 54 PRT-50 Not determined 72 5 0 0 135 58 PRT-51 5 109 11 0 0 118 55 PRT-52 6 104 12 0 0 122 49 PRT-53 Not determined 96 84 7 61 9 55 PRT-54 3 117 24 0 10 110 50 PRT-55 3 153 70 0 57 19 51 PRT-56 4 123 13 0 3 125 51 PRT-57 4 85 52 0 55 44 51 PRT-58 3 128 9 0 1 125 59 PRT-59 Not determined 104 70 6 56 8 54 PRT-60 3 117 133 52 16 16 54 PRT-61 4 118 55 0 50 52 53 PRT-62 3 133 94 15 56 8 55 PRT-63 3 125 120 44 19 13 51 PRT-64 4 99 123 50 17 16 55 PRT-65 3 91 100 35 34 26 53 PRT-66 3 116 115 49 13 15 55 PRT-67 Not determined 114 78 10 61 23 51 PRT-68 4 107 133 51 16 16 53 PRT-69 3 81 121 45 14 14 55 PRT-70 4 85 124 47 14 14 55 PRT-71 3 88 126 53 0 25 56 PRT-72 3 95 100 41 8 14 57 PRT-73 3 93 105 52 5 28 54 PRT-74 2 20 73 26 27 23 57 PRT-75 5 108 76 12 54 8 55 PRT-76 2 49 78 20 38 37 53 PRT-77 3 77 104 33 17 14 53 PRT-78 4 122 94 34 11 21 56 PRT-79 9 87 44 0 38 72 59 PRT-80 5 97 70 15 34 29 61 PRT-81 2 14 67 14 56 30 54 PRT-82 Not determined 62 67 9 60 15 56 PRT-83 5 83 44 0 40 42 54 PRT-84 4 97 67 8 51 27 56 PRT-85 3 60 0 0 0 109 51 PRT-86 3 76 61 4 53 45 47 PRT-87 4 102 52 0 50 60 54 PRT-88 3 85 110 48 0 25 55 PRT-89 2 57 89 45 0 34 55 PRT-90 3 60 106 44 0 21 56 PRT-91 5 96 102 40 9 16 56 PRT-92 3 62 104 40 6 8 55 PRT-93 3 79 91 38 0 11 53 huIgG_cntrl1 not found 0 0 0 1159 PRT-CNTRL 5 107 196 732 0 0 55 PRT-94 12 100 120 547 0 0 54 PRT-95 14 108 118 242 0 102 53 PRT-96 10 77 156 482 0 0 52 PRT-97 8 77 185 524 0 0 53 PRT-98 12 86 180 592 0 0 53 PRT-99 12 78 152 489 0 0 55 PRT-100 11 81 178 513 0 0 53 PRT-101 12 84 204 655 0 0 53 PRT-102 Not determined 86 160 607 0 0 51 PRT-103 13 100 158 544 0 0 53 PRT-104 16 102 130 259 0 0 53 PRT-105 8 94 192 663 13 0 53 PRT-106 11 89 202 739 0 0 52 PRT-107 5 65 200 553 117 0 55 PRT-108 14 112 203 666 0 0 56 PRT-109 11 86 181 457 0 28 61 PRT-110 15 131 136 575 0 0 58 PRT-111 12 130 133 328 0 26 56 PRT-112 6 90 152 435 0 15 59 PRT-113 5 67 189 656 0 0 51 PRT-114 4 98 162 361 111 129 58 PRT-115 11 96 128 124 105 24 58 PRT-116 4 70 188 510 0 0 56 PRT-117 8 71 207 663 0 0 54 PRT-118 2 56 85 23 153 0 56 PRT-119 15 127 96 15 133 0 63 PRT-120 6 99 113 92 153 28 54 PRT-121 5 55 174 447 0 0 61 PRT-122 9 101 194 565 0 138 50 PRT-123 5 65 187 468 0 0 61 PRT-124 6 92 202 676 0 0 56 PRT-125 10 100 197 609 0 0 56 PRT-126 13 112 160 472 0 0 56 PRT-127 Not determined 111 140 523 0 0 59 PRT-128 13 107 151 560 60 0 60 PRT-129 14 122 169 384 0 0 55 PRT-130 10 115 192 592 0 0 53 PRT-131 5 104 201 745 0 0 55 PRT-132 11 32 219 697 0 0 57 PRT-133 11 89 207 774 12 0 54 PRT-134 14 102 174 597 0 0 55 PRT-135 14 115 140 526 6 0 55 PRT-136 14 109 160 635 0 0 55 PRT-137 Not determined 99 198 662 0 0 54 PRT-138 16 157 215 563 144 0 55 PRT-139 10 96 213 733 0 0 55 PRT-140 5 93 213 755 0 0 53 PRT-141 9 92 215 846 0 0 53 PRT-142 13 151 135 589 0 0 54 PRT-143 7 103 170 576 0 0 53 PRT-144 12 119 151 562 26 0 50 PRT-145 11 101 207 735 0 0 49 PRT-146 7 124 215 672 0 0 50 PRT-147 10 108 206 723 0 0 45 PRT-148 8 87 203 764 0 0 52 PRT-149 5 87 0 831 0 0 50 PRT-150 5 73 161 612 0 0 52 PRT-151 7 103 137 521 0 0 50 PRT-152 8 82 158 614 0 0 55 PRT-153 16 106 190 619 0 0 53 PRT-154 15 136 191 733 0 0 53 PRT-155 9 124 197 751 18 0 52 PRT-156 8 112 205 772 0 0 55 PRT-157 8 105 198 806 0 0 54 PRT-158 14 94 163 637 0 0 54 PRT-159 15 103 184 637 0 0 56 PRT-160 6 61 168 642 0 0 50 PRT-161 13 100 172 669 0 0 46 PRT-162 9 122 196 729 0 0 55 PRT-163 12 103 184 706 0 29 55 PRT-164 13 69 203 508 85 0 55 PRT-165 13 81 204 783 0 0 54 PRT-166 12 60 161 597 0 0 55 PRT-167 14 94 161 572 0 0 56 PRT-168 13 68 159 628 0 0 56 PRT-169 5 66 188 658 0 0 55 PRT-170 13 119 193 755 0 0 55 PRT-171 7 63 187 765 0 23 57 PRT-172 13 82 215 821 0 0 55 PRT-173 5 71 226 912 30 0 52 PRT-174 14 111 160 586 0 0 51 PRT-175 15 86 147 497 0 0 51 PRT-176 7 22 140 310 86 0 38 PRT-177 12 13 105 67 426 131 37 PRT-178 3 136 196 695 0 0 56 PRT-179 5 73 187 697 0 0 56 PRT-180 6 78 197 690 0 0 53 PRT-181 5 51 217 890 0 24 58 PRT-182 Not determined 80 167 563 27 0 53 PRT-183 13 67 175 630 0 0 55 PRT-184 6 52 165 629 0 0 54 PRT-185 Not determined 11 45 0 152 365 48 PRT-186 6 119 218 646 0 9 54 0 huIgG_cntrl1 not found 0 0 0 1320 PRT-CNTRL 8.1 57 297 238 210 0 55 PRT-187 4.9 59 307 265 103 115 55 PRT-188 8.5 61 40 0 25 905 47 PRT-189 6.4 74 307 469 101 0 49 PRT-190 7.0 66 278 323 145 76 50 PRT-191 8.2 45 183 36 358 161 56 PRT-192 7.9 73 204 24 461 109 48 PRT-193 7.8 79 193 39 355 181 49 PRT-194 7.0 50 12 0 0 301 44 PRT-195 7.3 74 30 0 15 829 44 PRT-196 Not determined 38 498 152 504 707 52 PRT-197 Not determined 80 179 0 121 1802 55 PRT-198 Not determined 0 0 621 0 2324 Not determined PRT-199 Not determined 50 473 95 544 797 62 PRT-200 Not determined 0 0 0 0 2506 Not determined PRT-201 Not determined 23 0 0 0 2721 60 PRT-202 Not determined 81 402 25 553 1131 55 PRT-203 Not determined 0 0 0 0 2129 Not determined PRT-204 Not determined 0 0 0 0 2259 Not determined PRT-205 Not determined 41 216 127 278 1086 54 PRT-206 Not determined 0 0 570 0 2130 Not determined PRT-207 Not determined 49 249 0 287 1288 58 PRT-208 Not determined 64 153 0 113 1703 51 PRT-209 Not determined 49 124 0 71 1666 58 PRT-210 Not determined 24 87 0 25 1779 62 PRT-211 Not determined 64 68 0 0 2187 59 PRT-212 Not determined 18 435 13 599 1273 59 PRT-213 Not determined 51 244 0 301 1290 59 PRT-214 Not determined 38 27 467 0 1654 65 PRT-215 Not determined 125 310 73 309 708 58 PRT-216 Not determined 46 0 0 0 1665 43 PRT-217 Not determined 76 86 0 41 1584 62 PRT-218 Not determined 45 39 0 0 1783 60 PRT-219 Not determined 60 407 104 443 886 60 PRT-220 Not determined 30 61 0 0 2319 60 PRT-221 Not determined 81 439 117 461 653 55 PRT-222 Not determined 47 78 487 21 1551 55 PRT-223 Not determined 15 391 189 316 375 55 PRT-224 Not determined 60 382 217 314 344 56 PRT-225 Not determined 57 63 0 0 1503 54 PRT-226 Not determined 66 0 0 0 1960 55 PRT-227 Not determined 36 331 22 492 880 54 PRT-228 Not determined 47 583 195 557 767 49 PRT-229 Not determined 1 243 691 294 1272 56 PRT-230 Not determined 39 454 699 396 513 53 PRT-231 Not determined 58 388 176 313 465 51 PRT-232 Not determined 34 283 40 393 624 55 PRT-233 Not determined 39 376 94 415 596 52 PRT-234 Not determined 28 376 88 432 640 54 PRT-235 Not determined 20 448 116 483 711 51 PRT-236 Not determined 28 615 294 472 594 51 PRT-237 Not determined 31 415 828 461 685 53 PRT-238 Not determined 11 81 0 28 1613 56 PRT-239 Not determined 14 269 49 360 689 49 PRT-240 Not determined 3 82 0 36 1396 42

TABLE-US-00025 TABLE 15 Crude Enzyme Activity Endpoint Assay Expression Yield (purified) ng/ul (substrate pooled (LabChip) Purified human IgG) Thermostability Molecule ID ng/uL (mg/L) Fc Fab2 scIgG IgG Tm1 (? C.) huIgG1, 2, 3, 4 0 0 0 1818.87 Ide85 615 1130 0 0 IdeS 524 1355 0 0 IdeZ 481 1293 0 0 IdeZ2 566 1339 0 0 PRT-241 107 6 406 731 0 0 53 PRT-249 327 17 457 818 0 0 55 PRT-257 547 29 439 1048 0 0 53 PRT-265 0 0 3 0 0 1638 PRT-273 360 19 429 782 0 0 PRT-281 26 1 317 673 29 347 PRT-289 937 50 304 581 114 90 57 PRT-297 1491 80 345 484 0 338 50 PRT-305 760 41 359 786 0 91 53 PRT-313 1422 76 303 409 328 114 50 PRT-321 701 37 337 469 214 139 55 PRT-329 236 13 406 928 0 0 53 PRT-242 228 12 418 1031 0 0 54 PRT-250 463 25 310 313 454 86 54 PRT-258 708 38 425 762 0 0 39 PRT-266 106 6 401 698 0 0 60 PRT-274 0 0 425 1036 0 0 54 PRT-282 23 1 150 69 413 34 53 PRT-290 128 7 151 191 0 179 53 PRT-298 198 11 240 494 35 147 57 PRT-306 1689 90 336 467 0 341 51 PRT-314 1748 93 286 599 174 101 49 PRT-322 671 36 381 506 0 387 55 PRT-330 333 18 369 493 0 352 52 PRT-243 267 14 430 967 0 25 52 PRT-251 1326 71 444 1073 0 0 PRT-259 671 36 453 1098 0 0 49 PRT-267 144 8 438 1090 0 0 59 PRT-275 50 27 257 169 589 97 53 PRT-283 24 1 271 380 91 186 52 PRT-291 702 37 420 1023 0 0 53 PRT-299 333 18 378 549 0 368 56 PRT-307 517 28 290 215 614 138 53 PRT-315 995 53 408 981 0 0 50 PRT-323 765 41 256 130 743 235 55 PRT-331 283 15 398 954 0 0 52 PRT-244 337 18 429 998 0 0 48 PRT-252 1360 73 365 634 0 56 43 PRT-260 684 36 354 793 0 0 48 PRT-268 224 12 325 429 282 90 58 PRT-276 451 24 383 912 0 0 43 PRT-284 26 1 184 72 483 45 46 PRT-292 0 0 359 758 0 0 PRT-300 348 19 274 333 43 276 55 PRT-308 651 35 204 405 106 59 52 PRT-316 292 16 347 772 0 80 56 PRT-324 809 43 291 665 0 0 56 PRT-332 343 18 277 409 177 0 50 PRT-293 0 0 0 11 0 1260 PRT-301 0 0 0 0 0 1676 PRT-309 0 0 0 0 0 1646 PRT-317 552 29 453 798 0 0 54 PRT-325 432 23 466 930 0 78 54 PRT-333 252 13 448 794 0 0 54 PRT-294 2127 113 456 651 5 506 47 PRT-302 1046 56 461 1126 0 0 51 PRT-310 790 42 488 1224 0 0 48 PRT-318 201 11 365 641 100 110 60 PRT-326 903 48 429 588 0 458 54 PRT-295 875 47 398 529 0 446 52 PRT-303 24 1 482 1083 0 0 PRT-311 38 2 295 261 496 109 PRT-319 509 27 372 670 0 32 55 PRT-327 535 29 338 460 0 472 55 PRT-296 0 0 443 955 0 0 PRT-304 0 0 320 711 0 0 PRT-312 17 1 330 703 54 53 PRT-320 664 35 339 778 0 53 55 PRT-328 236 13 455 1004 0 75 54 PRT-334 129 7 257 59 738 154 PRT-342 0 0 209 15 841 206 PRT-350 130 7 243 520 200 668 PRT-358 0 0 90 8 375 86 PRT-366 0 0 122 0 472 777 PRT-335 129 7 154 38 514 74 PRT-343 130 7 266 154 682 129 PRT-351 129 7 191 37 638 86 PRT-359 144 8 340 260 677 202 PRT-367 134 7 361 351 518 100 PRT-336 129 7 264 50 965 370 PRT-344 169 9 335 562 218 0 53 PRT-352 131 7 302 229 599 281 PRT-360 130 7 241 89 684 191 PRT-368 130 7 3 0 0 0 PRT-337 0 0 74 0 259 38 PRT-345 129 7 248 61 772 123 PRT-353 129 7 259 101 767 189 PRT-361 129 7 243 86 753 130 PRT-369 131 7 284 259 445 123 PRT-338 442 24 203 766 287 0 53 PRT-346 518 28 217 607 246 0 53 PRT-354 525 28 213 618 233 0 53 PRT-362 534 28 225 720 299 0 53 PRT-370 615 33 348 654 288 0 53 PRT-339 271 14 167 721 288 0 53 PRT-347 443 24 397 769 309 0 53 PRT-355 445 24 500 952 367 0 53 PRT-363 366 20 462 838 354 0 53 PRT-371 553 29 373 623 295 0 53 PRT-340 456 24 374 692 307 0 53 PRT-348 548 29 415 736 325 0 53 PRT-356 441 24 418 780 289 0 53 PRT-364 540 29 439 863 334 0 53 PRT-374 589 31 536 985 379 0 53 PRT-341 424 23 199 832 318 0 53 PRT-349 487 26 215 677 286 0 53 PRT-357 459 24 389 724 313 0 53 PRT-365 482 26 385 735 312 0 53 PRT-375 513 27 115 170 180 0 53 PRT-553 45 2 229 79 764 111 56 PRT-526 207 11 379 246 627 110 57 PRT-586 56 3 322 478 458 77 56 PRT-595 121 6 452 1043 0 0 54 PRT-566 66 4 366 621 0 0 55 PRT-582 51 3 183 28 754 329 56 PRT-576 63 3 365 903 0 0 54 PRT-533 0 0 0 0 0 1139 PRT-245 447 24 277 423 204 46 40 PRT-253 602 32 334 912 0 0 50 PRT-261 88 5 76 0 317 615 48 PRT-269 44 2 189 98 592 86 PRT-559 1252 67 158 657 0 0 54 PRT-545 1034 55 435 690 0 0 54 PRT-587 738 39 156 347 120 0 54 PRT-596 353 19 348 753 263 0 54 PRT-571 254 14 383 786 295 0 53 PRT-583 968 52 396 748 261 0 52 PRT-544 0 0 170 12 748 314 PRT-534 0 0 0 0 0 1377 PRT-246 656 35 348 666 221 0 50 PRT-254 1347 72 359 677 0 0 43 PRT-262 541 29 191 50 802 289 35 PRT-270 439 23 288 376 311 100 48 PRT-554 62 3 350 580 0 36 55 PRT-555 258 14 475 670 0 0 54 PRT-575 54 3 309 254 607 94 58 PRT-567 50 3 297 385 372 65 55 PRT-573 274 15 409 759 0 0 54 PRT-556 411 22 351 570 200 16 53 PRT-541 0 0 0 0 3 854 PRT-538 0 0 0 5 0 1160 PRT-247 0 0 81 0 279 308 PRT-255 55 3 178 58 525 75 46 PRT-263 71 4 27 0 0 986 37 PRT-271 352 19 322 563 0 0 56 PRT-580 1250 67 282 566 0 0 55 PRT-528 639 34 114 14 691 354 55 PRT-574 979 52 357 660 227 0 54 PRT-599 423 23 310 930 0 0 54 PRT-561 520 28 405 606 0 0 51 PRT-581 786 42 365 660 0 0 53 PRT-542 0 0 0 0 0 1471 PRT-588 690 37 361 658 0 0 63 PRT-248 363 19 370 654 0 0 55 PRT-256 928 49 376 610 0 55 42 PRT-264 675 36 353 606 0 97 45 PRT-272 739 39 389 721 0 0 46 PRT-527 460 25 142 0 396 707 55 PRT-547 124 7 359 527 256 0 54 PRT-584 101 5 369 552 285 51 55 PRT-600 726 39 441 992 0 0 53 PRT-590 437 23 217 954 0 0 54 PRT-578 272 15 394 698 0 0 54 PRT-543 0 0 0 0 0 1473 PRT-589 269 14 352 863 0 0 56 PRT-277 587 31 160 19 705 401 43 PRT-285 0 0 0 0 0 1320 PRT-529 153 8 177 0 350 508 55 PRT-552 61 3 294 439 264 45 55 PRT-558 159 8 281 700 0 0 54 PRT-597 356 19 315 603 0 0 53 PRT-601 456 24 529 720 0 0 50 PRT-579 482 26 450 816 0 0 54 PRT-539 0 0 0 0 0 1404 PRT-278 483 26 315 547 0 0 52 PRT-286 302 16 352 650 0 0 46 PRT-546 1372 73 390 722 236 0 53 PRT-530 836 45 225 87 687 74 54 PRT-551 197 11 217 444 0 0 54 PRT-592 289 15 359 664 0 0 53 PRT-536 0 0 0 0 0 1527 PRT-562 938 50 380 705 238 0 55 PRT-540 0 0 0 0 0 1494 PRT-279 306 16 359 574 0 48 40 PRT-287 476 25 392 700 0 0 46 PRT-548 1182 63 458 727 0 0 53 PRT-560 56 3 233 210 312 41 57 PRT-593 430 23 396 797 0 0 52 PRT-591 0 0 34 0 0 671 PRT-535 0 0 0 6 0 1528 PRT-569 1080 58 294 723 0 0 55 PRT-537 0 0 0 0 0 1004 PRT-280 396 21 305 423 0 319 53 PRT-288 411 22 334 439 0 348 45 PRT-376 1451 77 325 496 196 0 53 PRT-385 1067 57 265 494 56 103 57 PRT-393 1736 93 317 663 0 0 55 PRT-401 440 23 329 624 0 128 54 PRT-409 216 12 313 658 0 0 51 PRT-417 1681 90 27 193 0 324 57 PRT-425 1669 89 27 568 0 169 60 PRT-443 1056 56 0 17 535 431 55 PRT-378 1006 54 319 477 207 0 55 PRT-386 1476 79 337 519 240 0 49 PRT-394 318 17 323 482 209 0 55 PRT-402 196 10 342 530 188 0 53 PRT-410 1129 60 297 567 0 206 53 PRT-418 1288 69 283 382 149 288 55 PRT-426 1110 59 283 508 0 243 58 PRT-444 354 19 321 494 286 0 53 PRT-379 373 20 370 599 226 0 54 PRT-387 1265 67 366 605 242 0 54 PRT-395 1177 63 358 544 204 0 54 PRT-403 453 24 332 569 40 166 53 PRT-411 1343 72 341 519 155 90 53 PRT-419 618 33 298 528 0 183 59 PRT-427 598 32 352 537 139 135 57 PRT-380 95 5 258 66 702 219 56 PRT-388 1280 68 338 481 222 34 52 PRT-396 1256 67 92 0 215 1007 58 PRT-404 259 14 0 0 0 1583 PRT-412 410 22 103 518 170 0 53 PRT-420 521 28 300 515 0 125 60 PRT-428 1383 74 336 505 119 90 59 PRT-381 1200 64 334 486 194 0 55 PRT-389 955 51 340 479 219 32 54 PRT-397 1237 66 243 102 498 93 56 PRT-405 550 29 218 86 558 406 49 PRT-413 1245 66 347 485 152 14 59 PRT-421 111502 5947 340 612 0 71 60 PRT-429 124592 6645 348 528 171 57 58 PRT-382 21379 1140 380 585 226 0 52 PRT-390 28472 1518 371 578 227 0 55 PRT-398 314 17 370 555 196 0 49 PRT-406 1062 57 299 435 108 135 50 PRT-414 1054 56 341 496 129 77 59 PRT-422 923 49 348 494 136 69 60 PRT-437 949 51 306 445 263 0 55 PRT-383 249 13 379 581 230 0 54 PRT-391 793 42 361 498 192 29 52 PRT-399 8134 434 0 0 0 1578 52 PRT-407 4826 257 277 209 396 90 PRT-415 2547 136 225 46 630 164 63 PRT-423 3064 163 0 398 0 1659 57 PRT-439 1011 54 191 179 528 325 54 PRT-384 968 52 0 365 0 1508 56 PRT-392 1049 56 354 513 196 0 53 PRT-400 1050 56 333 556 0 176 52 PRT-408 892 48 334 564 0 179 52 PRT-416 464 25 258 125 453 96 60 PRT-424 982 52 348 618 0 88 59 PRT-442 936 50 169 18 381 680 54 PRT-390 1146 61 371 578 227 0 55 PRT-398 249 13 370 555 196 0 49 PRT-406 656 35 299 435 108 135 50 PRT-414 1396 74 341 496 129 77 59 PRT-422 1289 69 348 494 136 69 60 PRT-437 890 47 306 445 263 0 55 PRT-433 216 12 489 575 224 0 52 PRT-598 833 44 172 567 213 0 53 PRT-383 82730 4412 379 581 230 0 54 PRT-391 38439 2050 361 498 192 29 52 PRT-399 13125 700 0 0 0 1578 52 PRT-407 15320 817 277 209 396 90 PRT-415 59643 3181 225 46 630 164 63 PRT-423 43183 2303 0 398 0 1659 57 PRT-439 1004 54 191 179 528 325 54 PRT-434 330 18 314 567 234 0 PRT-602 882 47 375 543 212 0 56 PRT-384 132579 7071 0 365 0 1508 56 PRT-392 2165 115 354 513 196 0 53 PRT-400 721 38 333 556 0 176 52 PRT-408 342 18 334 564 0 179 52 PRT-416 2873 153 258 125 453 96 60 PRT-424 2690 143 348 618 0 88 59 PRT-442 2183 116 169 18 381 680 54 PRT-435 2680 143 205 35 380 625 53 PRT-372 7 0 218 0 560 122 PRT-456 208 11 497 1172 0 0 59 PRT-446 744 40 427 1131 0 0 58 PRT-480 532 28 325 846 0 0 57 PRT-491 101 5 260 769 331 140 56 PRT-468 328 17 385 957 66 115 58 PRT-458 111 6 224 598 226 112 59 PRT-512 877 47 372 884 0 31 55 PRT-506 678 36 453 1115 0 43 54 PRT-502 1345 72 283 307 296 66 51 PRT-494 563 30 489 1212 0 0 56 PRT-618 748 40 419 976 0 0 48 PRT-670 559 30 174 0 798 594 61 PRT-454 9083 484 317 217 653 94 53 PRT-448 9626 513 0 0 0 2150 63 PRT-478 16264 867 453 509 362 216 51 PRT-476 1763 94 0 0 0 2094 58 PRT-466 337 18 362 404 303 161 50 PRT-460 138 7 108 49 64 26 61 PRT-513 720 38 367 397 0 374 54 PRT-508 750 40 0 0 0 0 57 PRT-503 0 0 0 0 0 0 PRT-496 1310 70 192 190 0 0 59 PRT-677 596 32 0 0 0 0 56 PRT-682 603 32 0 0 0 0 54 PRT-455 773 41 416 872 333 0 57 PRT-482 1111 59 322 261 738 146 55 PRT-479 1344 72 481 1343 0 0 54 PRT-477 1211 65 277 543 224 0 57 PRT-467 234 13 374 685 375 57 53 PRT-486 128 7 210 145 627 107 55 PRT-525 876 47 386 1337 0 0 44 PRT-522 976 52 253 736 0 0 45 PRT-504 573 31 442 1306 0 0 PRT-518 806 43 423 1219 0 0 51 PRT-693 934 50 436 1276 0 0 56 PRT-685 646 34 448 1201 0 0 PRT-452 0 0 0 0 0 1873 PRT-483 1036 55 459 1260 0 0 59 PRT-471 1170 62 357 1112 0 0 PRT-493 795 42 412 1173 0 0 54 PRT-464 275 15 58 0 0 0 58 PRT-487 181 10 22 0 0 0 58 PRT-514 1323 71 37 64 0 0 52 PRT-523 1286 69 24 17 0 0 48 PRT-500 1404 75 30 25 0 0 56 PRT-519 599 32 17 0 0 0 53 PRT-614 1592 85 0 0 0 0 43 PRT-662 2254 120 13 8 0 0 51 PRT-453 569 30 607 1618 0 17 59 PRT-451 1278 68 324 1248 0 0 59 PRT-481 877 47 429 1385 0 65 56 PRT-474 1051 56 156 462 229 0 59 PRT-465 162 9 296 504 501 111 59 PRT-463 1372 73 259 821 0 0 58 PRT-517 0 0 0 0 22 ? PRT-511 982 52 312 935 0 62 55 PRT-501 0 0 0 0 0 1953 PRT-498 1264 67 318 488 124 325 56 PRT-688 1738 93 0 0 0 1947 59 PRT-667 1685 90 197 61 896 279 55 PRT-485 457753 24414 0 0 0 1397 58 PRT-450 762961 40691 282 300 481 227 61 PRT-470 673512 35921 363 1081 0 0 57 PRT-492 794154 42355 207 54 1020 362 56 PRT-489 133077 7097 0 0 0 0 PRT-462 687566 36670 0 0 0 0 59 PRT-515 978 52 0 0 0 0 56 PRT-510 929 50 29 51 0 0 57 PRT-521 1202 64 13 0 0 0 51 PRT-520 1114 59 265 271 475 470 53 PRT-636 1441 77 17 12 0 0 53 PRT-447 469 25 255 376 0 445 57 PRT-484 1148 61 277 143 973 173 57 PRT-472 1076 57 386 1129 0 0 60 PRT-473 1222 65 384 1342 0 59 57 PRT-459 216 12 193 137 415 373 56 PRT-488 1145 61 246 134 803 216 56 PRT-507 741 40 355 927 0 112 54 PRT-524 736 39 285 474 0 676 48 PRT-505 201 11 148 37 752 609 56 PRT-499 557 30 365 637 45 436 57 PRT-689 97 5 248 335 174 376 55 PRT-457 948 51 379 450 337 138 59 PRT-449 1231 66 365 1097 0 0 58 PRT-490 1037 55 243 73 875 166 53 PRT-475 1418 76 413 1149 0 0 59 PRT-469 225 12 139 41 248 50 55 PRT-461 1263 67 309 399 298 154 57 PRT-516 910 49 23 16 0 0 56 PRT-509 512 27 26 21 0 0 54 PRT-495 1313 70 37 0 0 0 55 PRT-497 749 40 0 0 0 0 55 PRT-635 0 0 0 0 0 0 PRT-687 496 26 420 738 295 0 53 PRT-624 581 31 251 89 626 96 PRT-643 850 45 409 664 226 33 46 PRT-646 807 43 435 582 635 39 43 PRT-658 1206 64 473 822 317 0 53 PRT-609 972 52 216 460 726 702 51 PRT-661 621 33 121 187 70 0 52 PRT-686 1025 55 355 608 252 0 53 PRT-692 852 45 44 442 38 429 51 PRT-623 864 46 260 433 157 0 52 PRT-696 854 46 0 58. 19 1020 51 PRT-549 197 11 491 725 279 0 58 PRT-637 671 36 188 278 602 464 47 PRT-625 839 45 405 451 531 78 52 PRT-644 632 34 518 882 355 0 47 PRT-647 306 16 465 777 330 0 52 PRT-650 711 38 452 522 600 130 51 PRT-683 971 52 570 1100 0 0 53 PRT-617 253 13 34 630 25 798 42 PRT-675 643 34 400 448 456 229 54 PRT-673 427 23 252 34 989 601 54 PRT-613 667 36 433 686 251 15 39 PRT-695 827 44 433 781 0 66 60 PRT-531 763 41 212 756 0 0 PRT-631 665 35 419 749 0 0 54 PRT-626 750 40 388 569 225 0 51 PRT-645 1013 54 455 683 236 0 49 PRT-604 190 10 276 51 964 396 51 PRT-649 787 42 32 657 24 886 48 PRT-638 605 32 10 550 17 823 51 PRT-680 1051 56 451 752 277 0 55 PRT-676 692 37 136 107 118 0 49 PRT-669 992 53 457 808 0 0 55 PRT-616 1021 54 495 943 0 0 53 PRT-570 801 43 126 551 0 0 PRT-557 675 36 410 512 194 0 54 PRT-628 425 23 465 852 0 0 50 PRT-652 142 8 0 410 12 789 PRT-653 142 8 0 1353 0 2353 PRT-656 359 19 540 841 319 0 49 PRT-648 170 9 206 182 619 417 49 PRT-679 169 9 327 693 54 34 57 PRT-664 432 23 419 703 0 0 57 PRT-674 554 30 0 462 12 891 49 PRT-672 961 51 443 775 0 73 PRT-678 0 0 0 56 0 39 PRT-572 755 40 478 936 0 0 PRT-550 493 26 389 891 0 0 PRT-627 232 12 415 767 187 124 49 PRT-655 0 0 0 471 15 1376 PRT-622 812 43 423 823 0 0 56 PRT-612 648 35 533 986 0 0 51 PRT-606 682 36 406 737 0 0 53 PRT-639 736 39 450 788 0 0 53 PRT-668 157 8 0 563 14 1069 58 PRT-666 608 32 132 897 0 66 PRT-607 321 17 470 779 0 0 51 PRT-671 161 9 294 97 864 244 56 PRT-565 158 8 471 783 0 0 54 PRT-532 150 8 118 409 217 506 55 PRT-629 166 9 425 542 461 161 56 PRT-654 142 8 0 401 11 1173 PRT-620 703 38 448 792 0 0 56 PRT-659 211 11 499 946 0 0 51 PRT-615 393 21 441 778 0 0 PRT-640 648 35 507 951 0 0 51 PRT-634 587 31 394 755 0 0 54 PRT-665 524 28 414 816 109 63 54 PRT-632 462 25 399 703 0 0 PRT-691 143 8 337 184 682 110 PRT-563 270 14 389 816 0 0 PRT-630 257 14 464 850 0 0 51 PRT-608 614 33 484 863 0 0 52 PRT-621 561 30 514 976 0 0 55 PRT-657 589 31 250 430 0 0 53 PRT-681 929 50 492 915 0 0 53 PRT-642 678 36 260 175 760 360 50 PRT-633 500 27 429 749 0 0 54 PRT-663 510 27 456 825 0 0 56 PRT-619 147 8 283 140 591 102 PRT-697 397 21 430 701 161 221 58 PRT-568 532 28 402 880 0 0 PRT-651 471 25 367 542 359 168 52 PRT-610 743 40 381 688 0 0 51 PRT-611 575 31 490 924 0 0 51 PRT-660 148 8 320 161 668 105 PRT-605 294 16 357 617 157 100 47 PRT-641 654 35 336 975 0 0 52 PRT-684 423 23 542 1061 0 0 55 PRT-690 378 20 482 966 0 0 50 PRT-603 925 49 486 965 0 0 50 PRT-694 0 0 0 541 15 1034 PRT-564 311 17 351 651 0 0 PRT-373 1006 54 295 392 281 38 52 PRT-377 1343 72 348 572 242 0 51 PRT-430 955 51 330 492 324 0 PRT-431 923 49 310 521 230 0 54 PRT-432 1050 56 305 462 385 0 PRT-433 216 12 489 575 224 0 PRT-434 330 18 314 567 234 0 PRT-435 2680 143 205 35 380 625 53 PRT-436 1476 79 305 445 379 0 53 PRT-438 618 33 320 578 249 0 PRT-440 1237 66 328 575 245 0 PRT-441 949 51 310 514 217 0 56 PRT-445 892 48 330 559 259 0 55 PRT-577 1245 66 338 566 230 0 54 PRT-585 793 42 303 574 229 0 54 PRT-594 982 52 271 138 487 123 54 PRT-598 833 44 172 567 213 0 53 PRT-602 882 47 375 543 212 0 56

TABLE-US-00026 TABLE 16 Enzyme Activity Endpoint Crude Assay (purified) ng/ul Expression (substrate pooled human IgG) Molecule ID (LabChip) ng/uL Fc Fab2 scIgG IgG huIgG_CNTRL N/A 0 0 0 1140 VRT-CNTRL1 140 337 178 177 0 VRT-1 35 334 175 137 197 VRT-2 7 238 97 100 247 VRT-3 2 99 0 50 808 VRT-4 0 29 0 24 990 VRT-5 37 294 137 151 89 VRT-6 39 304 132 172 78 VRT-7 15 258 61 249 178 VRT-8 38 126 0 125 652 VRT-10 27 266 56 169 71 VRT-11 0 90 0 38 829 VRT-12 0 101 0 64 747 VRT-13 0 97 0 42 814 VRT-14 36 4 0 22 1020 VRT-16 0 130 0 91 682 VRT-17 0 5 0 20 1033 VRT-18 0 4 0 9 995 VRT-19 0 54 0 33 1254 VRT-20 0 5 0 12 981 VRT-21 0 6 0 11 949 VRT-22 0 31 0 21 1007 VRT-23 0 29 0 20 1007 VRT-24 2 187 0 249 392 VRT-25 29 204 12 284 183 VRT-26 3 213 0 342 303 VRT-27 0 92 0 33 1151 VRT-28 2 3 0 22 987 VRT-30 0 46 0 22 986 VRT-31 0 27 0 21 1020 VRT-32 0 96 0 79 803 VRT-33 12 5 0 21 1037 VRT-34 10 5 0 20 1018 VRT-35 0 25 0 22 1019 VRT-36 0 112 0 62 1030 VRT-37 0 101 0 38 854 VRT-38 0 27 0 20 990 VRT-39 0 27 0 22 1025 VRT-40 75 243 63 222 167 VRT-42 0 28 0 20 985 VRT-43 3 28 0 23 1007 VRT-44 18 28 0 21 1066 VRT-47 3 317 168 156 253 VRT-48 10 222 9 258 134 VRT-49 20 291 135 131 157 VRT-50 13 226 8 360 295 VRT-52 0 213 6 311 238 VRT-53 24 209 0 339 326 VRT-54 105 129 0 150 672 VRT-55 25 120 0 109 734 VRT-56 44 200 0 240 742 VRT-57 0 97 0 27 903 VRT-58 67 191 0 236 527 VRT-59 21 157 0 107 726 VRT-202 54 393 140 80 49 VRT-203 0 59 0 26 1191 VRT-205 0 35 0 25 1179 VRT-206 71 404 176 129 68 VRT-60 67 487 173 236 101 VRT-61 39 538 129 281 25 VRT-63 0 68 0 11 1181 VRT-64 28 45 0 0 1062 VRT-65 35 475 146 180 72 VRT-66 0 69 0 0 1401 VRT-67 37 472 130 218 77 VRT-68 39 476 159 235 70 VRT-69 38 336 0 400 108 VRT-70 0 45 0 0 1349 VRT-71 0 50 0 0 1113 VRT-72 0 335 11 432 111 VRT-73 0 47 0 0 1283 VRT-74 0 71 0 25 1055 VRT-77 0 67 0 0 1296 VRT-78 0 260 0 325 127 VRT-79 0 153 0 109 748 VRT-80 0 48 0 0 999 VRT-81 0 47 0 26 1190 VRT-83 0 49 0 0 1044 VRT-84 0 70 0 0 1147 VRT-85 0 500 217 152 0 VRT-88 0 466 133 110 70 VRT-89 0 291 0 410 253 VRT-90 29 477 172 117 0 VRT-91 0 326 0 321 270 VRT-93 0 430 76 203 77 VRT-94 0 217 0 253 690 VRT-95 0 47 0 0 1154 VRT-96 0 45 0 26 1080 VRT-97 0 378 51 282 99 VRT-98 0 44 0 26 1119 VRT-99 54 386 151 89 209 VRT-101 49 505 150 0 0 VRT-102 31 441 174 40 190 VRT-103 0 297 0 259 383 VRT-104 0 177 0 138 687 VRT-105 26 434 208 42 0 VRT-107 0 198 0 157 545 VRT-108 42 229 0 254 598 VRT-109 51 337 54 293 0 VRT-113 0 161 0 76 1100 VRT-114 37 261 13 285 189 VRT-115 41 258 20 356 428 VRT-116 0 275 0 261 451 VRT-117 52 149 0 192 482 VRT-118 29 273 26 273 315 VRT-119 25 178 0 247 491 VRT-120 41 202 12 214 462 VRT-121 38 161 0 196 756 VRT-122 0 186 0 193 645 VRT-123 38 237 16 262 462 VRT-124 34 267 17 367 421 VRT-125 0 320 14 345 438 VRT-126 0 143 0 0 933 VRT-127 0 183 0 56 757 VRT-128 0 136 0 0 1048 VRT-130 0 21 0 0 1248 VRT-131 0 117 0 36 768 VRT-132 0 105 0 32 1209 VRT-133 0 133 0 0 1119 VRT-134 0 162 0 137 591 VRT-135 94 415 127 65 112 VRT-136 76 381 102 34 119 VRT-137 93 319 27 319 73 VRT-138 63 454 106 148 93 VRT-139 93 402 113 107 105 VRT-140 45 243 0 330 324 VRT-141 93 482 151 64 142 VRT-142 70 329 0 383 283 VRT-143 64 388 114 121 89 VRT-144 51 382 97 163 64 VRT-145 70 393 111 142 84 VRT-146 67 470 174 104 175 VRT-147 57 384 120 57 113 VRT-148 0 282 0 388 238 VRT-149 0 309 29 339 155 VRT-150 0 278 17 271 177 VRT-151 0 148 0 41 849 VRT-152 22 291 40 276 190 VRT-153 0 258 0 274 354 VRT-154 0 223 0 254 391 VRT-155 30 337 35 349 232 VRT-156 38 238 0 332 457 VRT-158 54 248 0 348 282 VRT-159 39 125 0 0 1142 VRT-161 50 257 0 356 262 VRT-162 35 218 0 344 332 VRT-164 61 356 0 426 85 VRT-165 0 36 0 0 1318 VRT-166 0 27 0 0 1229 VRT-169 0 36 0 0 1420 VRT-170 0 25 0 0 1248 VRT-62 224 333 124 161 15 VRT-75 0 10 0 14 1213 VRT-76 93 382 279 161 104 VRT-82 0 0 0 32 1413 VRT-85 54 401 302 315 109 VRT-92 49 436 330 232 0 VRT-100 144 395 304 370 0 VRT-110 109 260 74 630 282 VRT-111 53 205 71 294 392 VRT-112 96 226 50 545 36 VRT-129 0 209 27 322 311 VRT-157 49 273 60 208 374 VRT-159 101 280 115 402 169 VRT-163 62 253 60 405 75 VRT-167 0 148 0 249 565 VRT-168 0 10 0 366 983 VRT-171 43 143 5 215 713 VRT-172 0 162 488 180 510 VRT-173 0 4 0 12 1269 VRT-174 0 3 0 48 1259 VRT-175 47 183 21 404 591 VRT-176 48 155 7 344 826 VRT-177 59 232 19 390 658 VRT-179 48 140 0 637 392 VRT-180 54 131 0 200 816 VRT-181 92 172 24 390 568 VRT-182 67 187 13 276 731 VRT-183 89 53 0 113 1125 VRT-184 105 0 0 104 1069 VRT-185 45 102 0 601 862 VRT-186 54 99 0 119 988 VRT-187 66 98 0 610 712 VRT-188 0 5 0 13 1469 VRT-189 69 62 0 96 1110 VRT-190 65 86 0 0 1450 VRT-191 56 43 0 14 1252 VRT-192 61 90 0 115 1011 VRT-193 102 9 0 411 968 VRT-194 99 3 0 101 1309 VRT-196 0 114 0 206 849 VRT-197 0 59 0 9 1111 VRT-198 93 434 370 147 0 VRT-199 111 443 368 190 0 VRT-200 149 397 321 320 102 VRT-204 0 136 0 151 865 VRT-62 210 390 294 388 0 VRT-75 0 10 0 26 1255 VRT-76 101 394 269 229 0 VRT-82 0 0 0 12 1431 VRT-86 65 438 304 459 0 VRT-92 61 347 275 242 0 VRT-100 162 449 368 294 123 VRT-110 163 236 84 464 120 VRT-111 59 238 117 362 287 VRT-112 91 207 36 372 25 VRT-129 0 226 30 372 286 VRT-157 59 275 58 440 144 VRT-159 130 363 196 178 507 VRT-163 95 237 41 354 56 VRT-167 41 194 9 266 490 VRT-168 0 9 0 328 1454 VRT-171 52 209 37 365 481 VRT-172 0 143 5 172 510 VRT-173 0 41 0 10 1001 VRT-174 40 0 0 12 1439 VRT-175 56 251 49 539 439 VRT-176 72 156 0 658 179 VRT-177 66 235 25 419 510 VRT-179 80 139 0 583 215 VRT-180 74 179 16 359 549 VRT-181 104 177 23 367 571 VRT-182 95 223 26 264 549 VRT-183 99 53 0 111 1205 VRT-184 112 0 0 13 1400 VRT-185 72 93 0 450 303 VRT-186 73 125 0 119 784 VRT-187 124 130 0 145 269 VRT-188 0 0 0 29 1297 VRT-189 96 58 0 19 1249 VRT-190 96 77 0 107 1105 VRT-191 124 62 0 48 776 VRT-192 102 103 0 118 758 VRT-193 109 9 0 75 1242 VRT-194 121 3 0 105 1420 VRT-196 0 225 112 309 237 VRT-197 0 74 0 535 1060 VRT-198 115 383 339 192 0 VRT-199 144 357 0 0 0 VRT-200 207 423 369 138 0 VRT-204 0 152 0 174 1055 VRT-207 0 16 0 0 1097 VRT-208 0 106 0 0 880 VRT-209 0 17 0 0 1062 VRT-210 0 25 0 0 1130 VRT-211 0 116 0 0 912 VRT-212 0 18 0 0 1216 VRT-213 0 122 0 94 827 VRT-214 0 19 0 0 1473 VRT-215 0 15 0 0 1262 VRT-216 0 11 0 0 1322 VRT-217 0 119 0 57 961 VRT-218 0 27 0 0 1272 VRT-219 0 39 0 0 2524 VRT-220 0 20 0 0 1239 VRT-221 0 20 0 0 1368 VRT-222 0 18 0 0 1337 VRT-223 0 0 0 0 1353 VRT-224 0 13 0 0 1293 VRT-225 0 18 0 0 1362 VRT-227 27 106 0 33 1244 VRT-228 0 23 0 0 1502 VRT-229 0 16 0 0 1293 VRT-230 0 11 0 0 1269 VRT-231 0 88 0 0 1215 VRT-232 0 12 0 0 1137 VRT-233 0 11 0 0 1062 VRT-234 0 115 0 0 1194 VRT-235 0 19 0 0 1149 VRT-236 0 246 0 151 1021 VRT-237 0 182 0 230 438 VRT-238 0 16 0 0 1158 VRT-239 0 95 0 0 972 VRT-240 0 165 0 190 456 VRT-241 0 13 0 0 1118 VRT-242 0 144 0 138 605 VRT-243 0 29 0 0 1091 VRT-244 0 50 0 0 2156 VRT-245 0 20 0 0 1090 VRT-246 36 340 164 15 76 VRT-247 31 189 0 74 1702 VRT-249 30 357 146 120 77 VRT-250 28 84 0 0 1038 VRT-251 0 11 0 0 1030 VRT-252 0 296 29 272 0 VRT-253 0 15 0 0 1479 VRT-254 0 16 0 0 1228 VRT-255 0 217 0 378 441 VRT-256 0 16 0 0 1391 VRT-257 0 0 0 0 1164 VRT-258 0 21 0 340 255 VRT-259 0 19 0 0 1097 VRT-260 0 19 0 0 1132 VRT-262 0 19 0 0 1230 VRT-263 0 14 0 0 1245 VRT-264 99 140 0 137 768 VRT-265 105 113 0 105 935 VRT-266 112 9 0 51 1187 VRT-267 95 20 0 64 1660

Example 13: Polypeptides Having Protease Activity Comprise Mutations that Either Increase or Decrease Pre-Existing Anti-Protease Antibody Recognition of Ig Proteases

[0762] A competition assay for measuring pre-existing human anti-protease antibodies (MSD competition assay) was used to measure the ability of a mutant (or wild-type) protease in solution to compete for anti-protease antibodies present in IVIG and reduce the binding of those anti-protease antibodies to plate captured wild-type protease. This enabled to assess whether mutations made to a protease ablated its recognition by anti-protease antibodies present in IVIG allowing a greater proportion of the pre-existing antibodies to bind the plate captured wild-type protease.

[0763] Briefly, a mouse anti-his tag antibody was coated onto a MSD plate and incubated overnight at 4? C. Parental wild-type protease (for example IdeS) was inactivated with iodocetamide and captured via its His Tag onto the anti-His coated plate surface and washed after 1 hr at room temperature. Diluted human IVIG was mixed and incubated with test article proteases (which may be wild-type or polypeptides having protease activity) for 1 hr at room temperature. The IVIG/test article protease mixture was applied to the plate upon which parental protease was captured and incubated for 1 hr, allowing any pre-existing anti-protease antibodies present in the IVIG, and which are not complexed with test article, to bind the plate captured wild-type protease. After washing, anti-protease antibodies bound to the plate captured wild-type protease were detected using a biotinylated anti-human IgG (H+L) antibody which was applied to the plate for one hour at room temperature. After washing, a streptavidin-sulfotag reagent was applied to the plate. After another washing step the MSD read buffer was added and the plates were read on the MSD model 1300.

[0764] Signals from the assay were normalized as =1/[signal for test article/signal for wild-type]. The value of this normalized signal was interpreted as follows: [0765] (1) If normalized signal=1.0 then no change in pre-existing anti-protease antibody recognition of test article relative to wild-type protease; [0766] (2) If normalized signal<1.0 then there is reduced anti-protease antibody recognition of test article relative to wild-type protease; [0767] (3) If normalized signal>1.0 then there is increased anti-protease antibody recognition of test article relative to wild-type protease.

[0768] The data shown in Table 17, Table 18, and Table 19 illustrates polypeptides having protease activity comprising mutations that can either increase or decrease pre-existing anti-protease recognition of these Ig proteases.

TABLE-US-00027 TABLE 17 IdeS mutants Ide85 mutants IdeZ mutants Normalized Normalized Normalized assay signal assay signal assay signal for IdeS for Ide85 for IdeZ mutants plated mutants plated mutants plated against IdeS against IdeS against IdeS Molecule and IdeS used Molecule and Ide85 used Molecule and IdeZ used ID to normalize ID to normalize ID to normalize PRT-5 0.63 PRT-71 1.12 PRT-106 0.32 PRT-7 0.64 PRT-72 1.04 PRT-107 0.33 PRT-6 0.70 PRT-73 0.96 PRT-108 0.32 PRT-8 0.63 PRT-75 1.17 PRT-109 0.28 PRT-13 0.45 PRT-76 0.79 PRT-110 0.28 PRT-15 0.43 PRT-77 0.86 PRT-111 0.30 PRT-14 0.44 PRT-78 0.82 PRT-112 0.32 PRT-16 0.42 PRT-79 0.86 PRT-113 0.33 PRT-17 0.53 PRT-80 0.77 PRT-114 0.33 PRT-18 0.51 PRT-82 0.63 PRT-115 0.32 PRT-19 0.36 PRT-83 0.72 PRT-116 0.34 PRT-20 0.55 PRT-84 0.86 PRT-117 0.31 PRT-21 0.37 PRT-85 0.60 PRT-118 0.30 PRT-23 0.90 PRT-86 0.76 PRT-119 0.31 PRT-22 0.93 PRT-87 0.76 PRT-120 0.32 PRT-24 0.57 PRT-88 1.19 PRT-121 0.33 PRT-25 0.49 PRT-89 1.15 PRT-122 0.34 PRT-26 0.55 PRT-90 1.15 PRT-123 0.32 PRT-27 0.88 PRT-91 0.80 PRT-124 0.31 PRT-28 0.95 PRT-92 0.98 PRT-125 0.28 PRT-29 0.77 PRT-93 0.94 PRT-126 0.29 PRT-31 1.21 PRT-94 0.90 PRT-127 0.32 PRT-30 0.91 PRT-95 0.97 PRT-128 0.30 PRT-32 1.01 PRT-96 0.94 PRT-129 0.29 PRT-33 0.96 PRT-97 0.97 PRT-130 0.31 PRT-34 1.00 PRT-98 1.09 PRT-131 0.29 PRT-35 1.05 PRT-99 1.07 PRT-133 0.29 PRT-36 1.11 PRT-100 1.10 PRT-134 0.28 PRT-37 1.00 PRT-101 1.06 PRT-135 0.29 PRT-39 0.98 PRT-102 0.96 PRT-136 0.30 PRT-38 1.01 PRT-103 1.07 PRT-137 0.29 PRT-40 0.99 PRT-104 1.11 PRT-138 0.28 PRT-41 0.73 PRT-105 1.07 PRT-139 0.29 PRT-42 0.82 PRT-2 1.02 PRT-140 0.28 PRT-43 0.75 PRT-72 1.16 PRT-141 0.31 PRT-44 0.63 PRT-73 1.11 PRT-142 0.27 PRT-45 0.62 PRT-80 0.82 PRT-47 0.53 PRT-81 0.73 PRT-46 0.66 PRT-83 0.81 PRT-48 0.32 PRT-84 0.72 PRT-49 0.57 PRT-87 0.68 PRT-50 0.53 PRT-88 0.94 PRT-51 0.42 PRT-89 1.02 PRT-52 0.44 PRT-90 0.98 PRT-53 0.83 PRT-91 0.92 PRT-54 0.93 PRT-92 0.93 PRT-55 0.94 PRT-2 1.00 PRT-56 0.63 PRT-187 0.85 PRT-57 0.68 PRT-58 0.80 PRT-59 0.97 PRT-60 1.07 PRT-61 0.91 PRT-62 1.08 PRT-63 0.86 PRT-64 0.98 PRT-65 0.97 PRT-66 1.25 PRT-67 0.96 PRT-68 1.05 PRT-69 0.89 PRT-70 1.16 PRT-143 0.56 PRT-144 0.48 PRT-145 0.47 PRT-146 0.44 PRT-147 0.40 PRT-148 0.83 PRT-149 0.77 PRT-150 0.67 PRT-151 0.79 PRT-152 0.93 PRT-153 0.73 PRT-154 0.71 PRT-155 0.63 PRT-156 0.87 PRT-157 0.88 PRT-158 0.68 PRT-159 0.81 PRT-160 0.66 PRT-161 0.52 PRT-162 0.73 PRT-163 0.65 PRT-164 0.68 PRT-165 0.61 PRT-166 0.61 PRT-167 0.80 PRT-168 0.84 PRT-169 0.68 PRT-170 0.73 PRT-171 0.66 PRT-172 0.64 PRT-173 0.63 PRT-174 0.57 PRT-175 0.44 PRT-178 0.78 PRT-179 0.84 PRT-180 0.93 PRT-181 0.81 PRT-182 0.82 PRT-183 0.65 PRT-184 0.85 PRT-186 0.57 PRT-1 1.06 PRT-6 0.73 PRT-7 0.63 PRT-8 0.54 PRT-9 0.67 PRT-11 0.51 PRT-12 0.48 PRT-15 0.44 PRT-17 0.54 PRT-18 0.49 PRT-19 0.44 PRT-20 0.47 PRT-23 0.64 PRT-24 0.58 PRT-25 0.50 PRT-27 0.86 PRT-31 0.97 PRT-32 1.03 PRT-33 1.03 PRT-34 0.82 PRT-35 0.92 PRT-36 0.96 PRT-40 0.95 PRT-41 0.72 PRT-43 0.70 PRT-44 0.61 PRT-49 0.69 PRT-63 0.86 PRT-64 1.00 PRT-65 0.98 PRT-66 0.89 PRT-67 0.94 PRT-1 0.93 PRT-4 0.83 PRT-9 0.62 PRT-10 0.51 PRT-11 0.50 PRT-12 0.42 PRT-188 0.36 PRT-189 0.88 PRT-190 0.81 PRT-191 0.74 PRT-192 0.46 PRT-193 0.43 PRT-194 0.32 PRT-195 0.30

TABLE-US-00028 TABLE 18 IdeZ2 mutants IdeZ mutants IdeS mutants Normalized Normalized Normalized assay signal assay signal assay signal for IdeZ2 for IdeZ for IdeS mutants plated mutants plated mutants plated against IdeS against IdeZ against IdeS Molecule and IdeS used Molecule and IdeZ used Molecule and IdeS used ID to normalize ID to normalize ID to normalize PRT-346 1.15 PRT-313 0.86 PRT-242 1.69 PRT-354 1.13 PRT-314 1.11 PRT-243 1.41 PRT-347 1.06 PRT-307 1.22 PRT-244 0.79 PRT-355 1.08 PRT-315 1.21 PRT-259 0.51 PRT-348 1.05 PRT-308 1.21 PRT-260 0.53 PRT-349 1.08 PRT-310 1.40 PRT-249 0.95 PRT-362 1.03 PRT-321 0.99 PRT-257 0.91 PRT-363 1.00 PRT-322 1.13 PRT-250 0.96 PRT-356 1.01 PRT-323 0.73 PRT-258 0.74 PRT-364 1.05 PRT-316 1.26 PRT-251 0.53 PRT-357 1.17 PRT-324 1.19 PRT-252 0.52 PRT-365 1.13 PRT-317 1.54 PRT-273 0.50 PRT-370 1.11 PRT-325 1.52 PRT-274 0.54 PRT-371 1.11 PRT-318 1.26 PRT-275 0.50 PRT-374 1.06 PRT-326 1.02 PRT-268 0.64 PRT-375 1.06 PRT-319 0.90 PRT-526 1.35 PRT-373 0.60 PRT-341 3.48 PRT-599 1.38 PRT-688 2.58 PRT-600 0.84 PRT-618 1.70 PRT-590 1.17 PRT-614 1.39 PRT-578 1.16 PRT-670 2.16 PRT-589 0.72 PRT-677 1.47 PRT-558 1.28 PRT-662 2.77 PRT-597 1.14 PRT-667 0.99 PRT-601 1.13 PRT-609 1.09 PRT-579 1.10 PRT-604 1.28 PRT-546 1.29 PRT-612 3.76 PRT-530 1.34 PRT-606 4.21 PRT-551 1.21 PRT-607 2.22 PRT-592 1.41 PRT-608 3.17 PRT-562 0.82 PRT-610 3.52 PRT-548 1.19 PRT-611 2.38 PRT-593 0.74 PRT-605 1.88 PRT-569 0.69 PRT-603 2.51 PRT-245 1.27 PRT-624 2.53 PRT-246 2.70 PRT-643 2.01 PRT-262 0.58 PRT-646 3.32 PRT-264 0.73 PRT-658 3.58 PRT-253 1.08 PRT-623 2.69 PRT-254 0.50 PRT-637 1.17 PRT-248 1.11 PRT-625 2.22 PRT-256 0.58 PRT-644 2.84 PRT-277 0.53 PRT-647 2.29 PRT-278 0.66 PRT-650 3.56 PRT-279 0.77 PRT-631 3.84 PRT-270 0.94 PRT-626 3.67 PRT-271 1.71 PRT-645 2.62 PRT-272 0.85 PRT-649 0.77 PRT-598 1.09 PRT-638 0.61 PRT-602 1.03 PRT-628 2.30 PRT-577 1.08 PRT-656 1.93 PRT-585 1.25 PRT-648 0.53 PRT-594 0.89 PRT-627 1.53 PRT-598 1.19 PRT-622 3.44 PRT-602 1.13 PRT-639 2.86 PRT-482 0.78 PRT-629 0.89 PRT-483 0.78 PRT-620 2.42 PRT-493 0.61 PRT-659 1.06 PRT-487 0.76 PRT-640 2.69 PRT-484 0.64 PRT-634 2.97 PRT-488 0.67 PRT-632 1.55 PRT-490 0.59 PRT-630 2.45 PRT-456 0.70 PRT-621 2.42 PRT-446 0.81 PRT-657 2.51 PRT-480 1.20 PRT-642 1.00 PRT-468 1.32 PRT-633 3.07 PRT-454 0.63 PRT-651 1.23 PRT-448 0.48 PRT-641 2.02 PRT-478 0.50 PRT-692 1.55 PRT-476 0.46 PRT-696 1.36 PRT-466 1.15 PRT-695 2.50 PRT-455 1.08 PRT-697 1.56 PRT-479 1.28 PRT-690 3.76 PRT-477 1.52 PRT-687 1.60 PRT-467 1.14 PRT-686 3.29 PRT-471 1.21 PRT-683 2.94 PRT-464 1.28 PRT-680 2.88 PRT-453 0.80 PRT-681 2.66 PRT-481 1.31 PRT-684 1.93 PRT-474 1.35 PRT-617 0.78 PRT-465 1.33 PRT-613 1.24 PRT-463 1.46 PRT-616 1.79 PRT-447 1.10 PRT-615 1.80 PRT-472 1.01 PRT-661 1.96 PRT-473 1.34 PRT-675 1.61 PRT-459 1.43 PRT-673 0.95 PRT-457 1.22 PRT-676 0.90 PRT-449 1.06 PRT-669 1.93 PRT-475 1.51 PRT-664 2.56 PRT-469 1.24 PRT-674 0.54 PRT-461 1.72 PRT-672 1.54 PRT-549 0.59 PRT-668 0.40 PRT-531 0.95 PRT-666 2.12 PRT-570 1.22 PRT-671 0.57 PRT-557 1.03 PRT-665 1.75 PRT-572 1.03 PRT-663 2.12 PRT-550 1.27 PRT-679 0.84 PRT-565 0.49 PRT-563 0.72 PRT-568 0.92 PRT-564 0.56 PRT-451 0.86 PRT-289 0.87 PRT-297 0.62 PRT-291 1.14 PRT-294 0.60 PRT-295 0.97 PRT-296 0.72 PRT-298 1.15 PRT-306 0.75 PRT-299 0.95 PRT-300 1.02 PRT-302 0.73 PRT-286 0.55 PRT-287 0.77 PRT-280 1.25 PRT-288 0.50 PRT-525 0.71 PRT-522 0.67 PRT-518 0.57 PRT-523 0.85 PRT-519 0.91 PRT-521 0.98 PRT-520 0.86 PRT-524 0.51 PRT-512 1.01 PRT-506 1.04 PRT-502 0.58 PRT-494 0.79 PRT-513 1.05 PRT-508 1.14 PRT-496 0.62 PRT-504 0.74 PRT-514 1.19 PRT-500 0.64 PRT-511 0.46 PRT-498 1.08 PRT-515 1.06

TABLE-US-00029 TABLE 19 IdeZ mutants Ide85 mutants Normalized assay Normalized assay signal for IdeZ signal for Ide85 mutants plated mutants plated against IdeS and against IdeS and Molecule IdeS used to Molecule IdeS used to ID normalize ID normalize PRT-313 0.48 PRT-289 0.87 PRT-314 0.47 PRT-297 0.62 PRT-307 0.50 PRT-291 1.14 PRT-315 0.40 PRT-294 0.60 PRT-308 0.52 PRT-295 0.97 PRT-310 0.42 PRT-305 0.72 PRT-321 0.52 PRT-298 1.15 PRT-322 0.57 PRT-306 0.75 PRT-323 0.47 PRT-299 0.95 PRT-316 0.67 PRT-300 1.02 PRT-324 0.52 PRT-302 0.73 PRT-317 0.57 PRT-286 0.55 PRT-325 0.59 PRT-287 0.77 PRT-318 0.66 PRT-280 1.25 PRT-326 0.51 PRT-288 0.50 PRT-319 0.57 PRT-525 0.71 PRT-327 0.56 PRT-522 0.67 PRT-320 0.55 PRT-518 0.57 PRT-329 0.46 PRT-523 0.85 PRT-330 0.53 PRT-519 0.91 PRT-331 0.54 PRT-521 0.98 PRT-332 0.55 PRT-520 0.86 PRT-333 0.48 PRT-524 0.51 PRT-328 0.59 PRT-512 1.01 PRT-344 0.90 PRT-506 1.04 PRT-338 1.88 PRT-502 0.58 PRT-339 1.49 PRT-494 0.79 PRT-340 2.00 PRT-513 1.05 PRT-341 1.92 PRT-508 1.14 PRT-636 0.63 PRT-496 0.62 PRT-693 0.75 PRT-504 0.74 PRT-682 0.77 PRT-514 1.19 PRT-685 1.00 PRT-500 0.64 PRT-688 0.76 PRT-511 0.46 PRT-618 0.64 PRT-498 1.08 PRT-614 0.49 PRT-515 1.06 PRT-670 0.96 PRT-677 0.76 PRT-662 0.75 PRT-667 0.55 PRT-609 0.62 PRT-604 0.50 PRT-612 0.82 PRT-606 0.96 PRT-607 0.58 PRT-608 0.88 PRT-610 0.71 PRT-611 0.64 PRT-605 0.66 PRT-603 0.61 PRT-624 0.80 PRT-643 0.67 PRT-646 0.67 PRT-658 0.95 PRT-623 0.71 PRT-637 0.59 PRT-625 0.77 PRT-644 0.81 PRT-647 0.57 PRT-650 1.01 PRT-631 0.84 PRT-626 0.85 PRT-645 0.68 PRT-649 0.61 PRT-638 0.49 PRT-628 0.61 PRT-656 0.54 PRT-648 0.43 PRT-627 0.58 PRT-622 1.01 PRT-639 0.82 PRT-629 0.46 PRT-620 0.77 PRT-659 0.43 PRT-640 0.66 PRT-634 0.71 PRT-632 0.49 PRT-630 0.60 PRT-621 0.55 PRT-657 0.78 PRT-642 0.52 PRT-633 0.60 PRT-651 0.53 PRT-641 1.14 PRT-692 0.70 PRT-696 0.74 PRT-695 0.84 PRT-697 0.69 PRT-690 0.92 PRT-687 0.44 PRT-686 0.72 PRT-683 0.71 PRT-680 0.81 PRT-679 0.44 PRT-681 1.30 PRT-684 1.41 PRT-617 1.82 PRT-613 2.07 PRT-616 1.15 PRT-615 1.36 PRT-661 0.97 PRT-675 0.87 PRT-673 1.84 PRT-676 1.67 PRT-669 0.86 PRT-664 0.64 PRT-674 1.66 PRT-672 1.02 PRT-668 2.36 PRT-666 0.77 PRT-671 2.41 PRT-665 0.96 PRT-663 1.05

Example 14: Polypeptides Having Protease Activity have Higher EC50 than Wild Type IdeS or IdeZ in Human Plasma Cleavage Assay

[0769] The test articles produced in CHO cells were first purified using standard protein purification methods, and then quantified using a protein assay kit. In a series of separate experiments, the human plasma was mixed with the purified test articles at concentrations ranging from 0.1 nM to 1000 nM. The mixtures were incubated overnight to allow the protease to cleave the immunoglobulins present in the plasma. After incubation, the remaining immunoglobulins were quantified. The EC50, or the concentration of the test article at which 50% of the immunoglobulins are cleaved, is calculated from a dose-response curve. The data shown in FIG. 6, and FIGS. 7A and 7B, and in tables below (each table showing data from the same experiment) shows that test articles have higher EC50 than Fc-IdeS WT or Fc-IdeZ WT molecules.

TABLE-US-00030 EC50 (nM) Donor Fc-IdeS WT VRT-317 VRT-318 Fc-IdeZ WT VRT-319 1 40 25 270 48 135 2 75 40 350 150 3 72 30 362 100 4 40 25 181 5 45 42 125 6 26 7 48 8 14 9 37 10 32 11 21 12 92 Average 45 32 258 48 128

TABLE-US-00031 EC50 (nM) EC50 (nM) Fc-IdeS WT Fc-IdeS WT EC50 (nM) EC50 (nM) (parent, (parent, VRT-317 VRT-318 EC50 (nM) Donor Seismic) CHO KEMP) (CHO KEMP) (CHO KEMP) VRT-275 1 45 42 151 990 84 2 34 38 102 740 95

Example 15: VRT-275 Demonstrates Reduced Immunogenicity Compared to Wildtype IdeS-Fc

[0770] 48 human donors were evaluated for pre-existing antibody binding to VRT-275 relative to wild type Fc-IdeS through an electrochemiluminescence (ECL) immunoassay. 93.75% of donor cells exhibited a lower levels of pre-formed IgG binding to the test article relative to WT Fc-IdeS, measured by ECL signal, as shown in FIG. 8.

Example 16: In Vivo PK/PD of VRT-275 Shows Greater than 90% Reduction in Human IVIG at 30 min after Dosing

[0771] C57/BL6 mice were administered intravenous immune globulin (IVIG) at a dose of 450 mg/kg, and randomized based on body weight for treatment with VRT-275 administered intravenously at various doses, or a vehicle control (PBS). Treatment was administered at 1 hour following administration of IVIG. Blood was collected at 0.5 hours, 2 hours, 4 hours, 24 hours, 48 hours, and 72 hours following treatment. VRT-275 had a half-life extending for at least 24 hours, and showed a greater than 90% reduction of IVIG at all tested timepoints and at both treatment doses relative to vehicle treated animals.

Example 17: In Vivo PK/PD of an Fc-Protease Shows Greater than 95% Reduction in Human IVIG at 30 min after Dosing

[0772] C57/BL6 animals were administered IVIG at a dose of 450 mg/kg, and randomized based on body weight for treatment with a VFC-5 fused to an exemplary protease administered intravenously, or a vehicle control (PBS). Treatment was administered 1 hour following administration of IVIG. Blood was collected at 0.5 hours, 2 hours, 4 hours, 24 hours, 48 hours, and 72 hours following treatment. The VFC-5 fused to an exemplary protease showed a half-life extending 24 hours, and greater than 95% reduction in blood IVIG at all tested timepoints relative to vehicle treated animals.

Example 18: VRT-317 Inhibits ADCC

[0773] Antibody dependent cellular cytotoxicity (ADCC) was evaluated in cell. Cells were opsonized with trastuzumab (Herceptin) at a fixed concentration for 30 minutes. Cells were then treated with a dose response of VRT-317 for 2 hours. VRT-317 inhibited ADCC at all concentrations tested illustrating that the protease was able to cleave the antibody and demonstrating its ability to be able to cleave different types of antibodies.

[0774] The examples and embodiments provided for herein demonstrate the unexpected and surprising results of the variants and proteins provided for herein. The molecules demonstrate polypeptides that have increased half-life when conjugated to a protease resistant Fc as well as proteases that are less immunogenic as compared to other proteases such as wild-type IdeS or imlifidase. By providing a proteins that are less immunogenic and/or have a longer half-life in vivo the products can be administered more than once as well as less frequently to, for example, achieve a therapeutic effect, such as reducing immunoglobulins in a subject. Without being bound to any particular theory, the reduction of immunoglobulins can lead to the treatment or a therapeutic effect in subjects with auto-immune disease, such as those provided for herein.

[0775] The disclosures of each and every patent, patent application, and publication cited herein are hereby incorporated herein by reference in their entirety. While various embodiments have been disclosed with reference to specific aspects, it is apparent that other aspects and variations of these embodiments may be devised by others skilled in the art without departing from the true spirit and scope of the embodiments. The appended claims are intended to be construed to include all such aspects and equivalent variations.