Peroxide cross-linking and high temperature melting

Abstract

Methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process are disclosed. A multiple step procedure for enabling the manufacturing of such material without size limitations is also disclosed.

Claims

1. A method of making a cross-linked polymeric material, wherein the method comprising the steps of: a. blending a polymeric material with at least one antioxidant at a concentration that is between 0.05 wt % and 66.0 wt % and at least one cross-linking agent at a concentration that is between 0.5 and 66.5 wt %; b. consolidating the blended polymeric material; c. heating the consolidated polymeric material to a temperature that is about 200 C. or more for a period of time, wherein the heating step comprises: i. heating the consolidated polymeric material to a temperature that is between about 200 C. and about 290 C., ii. maintaining the consolidated blended polymeric material at a temperature that is between about 200 C. and about 290 C., iii. heating the consolidated polymeric material to a temperature that is between about 290 C. and 350 C., and iv. maintaining the consolidated blended polymeric material at a temperature that is between about 290 C. and 350 C. for at least 5 hours but no more than 30 hours; and d. cooling the consolidated polymeric material, wherein the cooling step comprises: i. permitting the heated consolidated blended polymeric material to cool to a temperature that is between about 135 C. and about 180 C., ii. maintaining the consolidated blended polymeric material at a temperature that is between about 135 C. and about 180 C., and iii. permitting the consolidated blended polymeric material to cool to a temperature that is between about room temperature and 60 C.

2. The method according to claim 1, wherein at least one antioxidant is vitamin E or Tetrakis[methylene(3,5-di-tert-butylhydroxyhydrocinnamate)] methane.

3. The method according to claim 1, wherein at least one cross-linking agent is a peroxide, P130, a carbon-carbon initiator, 2,3-dimethyl-2,3-diphenylbutane, poly-1,4-diisopropylbenzene, or a mixture thereof.

4. The method according to claim 1, wherein the heating after consolidation is done in inert gas.

5. The method according to claim 1, wherein the heating after consolidation is done in air.

6. The method according to claim 1, wherein the consolidation is carried out at a temperature that is between 150 C. and 210 C.

7. The method according to claim 1, wherein the cross-linked polymeric material is further machined into a medical implant.

8. The method according to claim 1, wherein the consolidation is done by ram extrusion.

9. The method according to claim 1, wherein the antioxidant concentration is no more than 1.0 wt %.

10. The method according to claim 1, wherein the cross-linking agent initiates cross-linking in the polymeric material.

11. A method of making an interlocked hybrid material, wherein the method comprising the steps of: a. blending a polymeric material with at least one antioxidant at a concentration that is between 0.05 wt % and 66.0 wt % and at least one cross-linking agent at a concentration that is between 0.5 and 66.5 wt %; b. layering the blended polymeric material and a second material; c. consolidating the layers, thereby forming an interlocked hybrid material; d. heating the interlocked hybrid material to a temperature that is above 200 C. for a period of time, wherein the heating step comprises: i. heating the interlocked hybrid material to a temperature that is between about 200 C. and about 290 C., ii. maintaining the interlocked hybrid material at a temperature that is between about 200 C. and about 290 C., iii. heating the interlocked hybrid material to a temperature that is between about 290 C. and 350 C., and iv. maintaining the interlocked hybrid material at a temperature that is between about 290 C. and 350 C. for at least 5 hours but no more than 30 hours: and e. cooling the interlocked hybrid material, wherein the cooling step comprises: i. permitting the heated interlocked hybrid material to cool to a temperature that is between about 135 C. and about 180 C., ii. maintaining the interlocked hybrid material at a temperature that is between about 135 C. and about 180 C., and iii. permitting the interlocked hybrid material to cool to a temperature that is between about room temperature and 60 C.

12. The method according to claim 11, wherein the second material is a porous metal.

13. The method according to claim 11, wherein the interlocked hybrid material is consolidated in the form of a medical implant.

14. The method according to claim 11, wherein the interlocked hybrid material is machined into a medical implant.

15. The method according to claim 11, wherein the antioxidant concentration is no more than 1.0 wt %.

16. The method according to claim 11, wherein the cross-linking agent initiates cross-linking in the polymeric material.

17. The method according to claim 11, wherein the consolidation is carried out at a temperature that is between 150 C. and 210 C.

18. The method according to claim 11, wherein at least one antioxidant is vitamin E or Tetrakis[methylene(3,5-di-tert-butylhydroxyhydrocinnamate)]methane.

19. The method according to claim 11, wherein at least one cross-linking agent is a peroxide, P130, a carbon-carbon initiator, 2,3-dimethyl-2,3-diphenylbutane, poly-1,4-diisopropylbenzene, or a mixture thereof.

20. The method according to claim 11, wherein the heating after consolidation is done in inert gas.

21. The method according to claim 11, wherein the heating after consolidation is done in air.

22. The method according to claim 3, wherein the peroxide is selected from the group consisting: diacyl peroxides, peroxyesters, peoxydicarbonates, dialkyl peroxides, ketone peroxides, peroxyketals, cyclic peroxides, peroxymonocarbonates, hydroperoxides, benzoyl peroxide, dicumyl peroxide, methyl ethyl ketone peroxide, acetone peroxide, 2,5-Di(tert-butylperoxy)-2,5-dimethyl-3-hexyne, 3,3,5,7,7-pentamethyl-1,2,4 trioxepane, dilauryl peroxide, methyl ether ketone peroxide, t-amyl peroxyacetate, t-butyl hydroperoxide, t-amyl peroxybenzoate, Di-t-amyl peroxide, 2,5-Dimethyl 2,5-Di(t-butylperoxy)hexane, t-butylperoxy isopropyl carbonate, succinic acid peroxide, cumene hydroperoxide, 2,4-pentanedione peroxide, t-butyl perbenzoate, diethyl ether peroxide, acetone peroxide, arachidonic acid 5-hydroperoxide, carbamide peroxide, tert-butyl hydroperoxide, t-butyl peroctoate, t-butyl cumyl peroxide, Di-sec-butyl-peroxydicarbonate, Di-2-ethylhexylperoxydicarbonate, 1,1-Di(t-butylperoxy)cyclohexane, 1,1-Di(tert-butylperoxy)-3,3,5-trimethylcyclohexane, 2,5-Dimethyl-2,5-di(tert-butylperoxy)hexane, 3,3,5,7,7-Pentamethyl-1,2,4-trioxepane, Butyl 4,4-di(tert-butylperoxy)valerate, Di(2,4-dichlorobenzoyl) peroxide, Di(4-methylbenzoyl) peroxide, Di(tert-butylperoxyisopropyl)benzene, tert-Butyl cumyl peroxide, tert-Butyl peroxy-3,5,5-trimethylhexanoate, tert-Butyl peroxybenzoate, and tert-Butylperoxy 2-ethylhexyl carbonate, or mixtures thereof.

23. The method according to claim 19, wherein the peroxide is selected from the group consisting: diacyl peroxides, peroxyesters, peoxydicarbonates, dialkyl peroxides, ketone peroxides, peroxyketals, cyclic peroxides, peroxymonocarbonates, hydroperoxides, benzoyl peroxide, dicumyl peroxide, methyl ethyl ketone peroxide, acetone peroxide, 2,5-Di(tert-butylperoxy)-2,5-dimethyl-3-hexyne 3,3,5,7,7-pentamethyl-1,2,4 trioxepane, dilauryl peroxide, methyl ether ketone peroxide, t-amyl peroxyacetate, t-butyl hydroperoxide, t-amyl peroxybenzoate, Di-t-amyl peroxide, 2,5-Dimethyl 2,5-Di(t-butylperoxy)hexane, t-butylperoxy isopropyl carbonate, succinic acid peroxide, cumene hydroperoxide, 2,4-pentanedione peroxide, t-butyl perbenzoate, diethyl ether peroxide, acetone peroxide, arachidonic acid 5-hydroperoxide, carbamide peroxide, tert-butyl hydroperoxide, t-butyl peroctoate, t-butyl cumyl peroxide, Di-sec-butyl-peroxydicarbonate, Di-2-ethylhexylperoxydicarbonate, 1,1-Di(t-butylperoxy)cyclohexane, 1,1-Di(tert-butylperoxy)-3,3,5-trimethylcyclohexane, 2,5-Dimethyl-2,5-di(tert-butylperoxy)hexane, 3,3,5,7,7-Pentamethyl-1,2,4-trioxepane, Butyl 4,4-di(tert-butylperoxy)valerate, Di(2,4-dichlorobenzoyl) peroxide, Di(4-methylbenzoyl) peroxide, Di(tert-butylperoxyisopropyl)benzene, tert-Butyl cumyl peroxide, tert-Butyl peroxy-3,5,5-trimethylhexanoate, tert-Butyl peroxybenzoate, and tert-Butylperoxy 2-ethylhexyl carbonate, or mixtures thereof.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1. Defects in a consolidated 0.1 wt % vitamin E-blended UHMWPE after consolidation and high temperature exposure at 330 C. for 6 hours (a). A crossection of a cylinder is shown. The original cylinder subjected to processing was 6.7 cm in diameter and 5.6 cm in height (b). The dashed line denotes where the crossection was taken.

(2) FIG. 2. Examples of defects in different consolidated forms of UHMWPE. All samples were exposed to 320 C. for 6 hours. (a, b) 0.1 wt % vitamin E blended UHMWPE, cylindrical, direct compression molded pucks (67 mm diameter, 56 mm in height); (c) 0.2 wt % vitamin E blended UHMWPE, direct compression molded rectangular block (30 mm in height); (d) virgin (no additive) UHMWPE, barstock from compression molded sheet (89 mm in width, 89 mm in length, approximately 150 mm in height); (e) virgin (no additive) UHMWPE, ram extruded barstock (approximately 150 mm in height).

(3) FIG. 3. Schematic description of process which includes a step for pre-molding of pellet before high temperature treatment and second molding.

(4) FIG. 4. Probability of observing a defect in completely consolidated, then high temperature melted UHMWPE (60 by 60 by 100 mm) with increasing vinyl index.

(5) FIG. 5. Example of a UHMWPE cylindrical puck (67 mm in diameter, 43 mm in height) made by the pre-molding, heat treatment and complete consolidation steps without any defects.

(6) FIG. 6. Example of the formation of a tibial insert with highly cross-linked articular surface with good wear resistance and high temperature melt (HTM) treated bulk with good mechanical properties. The HTM treated bulk layer is prepared by molding a green polyethylene containing vitamin E followed by high temperature melting. Optionally this bulk layer is either fully consolidated first and then used in the molding steps described here or it is used as-is after the HTM step in the molding steps described here. The two layers are placed inside a mold and molded together at elevated temperature and pressure. The pressure is applied by the plunger. In some embodiments it is desirable to have three layers inside the mold. For example first a peroxide and antioxidant containing polyethylene blend at the bottom, then in the middle an HTM processed layer sandwiched between two layers of peroxide and antioxidant containing polyethylene blend.

(7) FIG. 7. Example of the formation of a tibial insert with highly cross-linked articular surface with good wear resistance and HTM treated bulk with good mechanical properties. The HTM treated bulk layer is prepared by molding a green polyethylene containing vitamin E followed by high temperature melting. Optionally this bulk layer is either first fully consolidated first and then used in molding steps described here or it is used as-is after the HTM step in the molding steps described here. The peroxide and antioxidant containing polyethylene blend is in the form of a powder blend; in some instances the terms resin and powder are used interchangeably. After the placement of the HTM processed layer into the mold, the powder blend is uniformly spread on top of the HTM processed layer. The two layers are then molded together at elevated temperature and pressure. The pressure is applied by the plunger. In some embodiments it is desirable to have three layers inside the mold. For example first a peroxide and antioxidant containing polyethylene blend at the bottom, then in the middle an HTM processed layer, and finally at the top another peroxide and antioxidant containing polyethylene blend. In some embodiments it is desirable to have three layers inside the mold. For example first a peroxide and antioxidant containing polyethylene blend powder at the bottom, then in the middle an HTM processed layer, and finally at the top another layer of peroxide and antioxidant containing polyethylene blend powder.

(8) FIG. 8 shows the cross-link density of vitamin E-blended and P130 cross-linked UHMWPE compared to radiation cross-linked UHMWPE.

(9) FIG. 9 shows the cross-link density as a function of (a) radiation dose and (b) peroxide content for radiation and peroxide cross-linked UHMWPEs respectively.

(10) FIG. 10 shows the wear rates as a function of the vitamin E content for peroxide cross-linked, vitamin E-blended UHMWPE pre and post gamma irradiation (25 kGy).

(11) FIG. 11 shows the high temperature melting (HTM) by-product index as a function of depth into the UHMWPE for blocks of different thickness.

(12) FIG. 12 shows the HTM by-products detected as a function of depth in ram extruded, vitamin E-blended, peroxide cross-linked UHMWPE before and after annealing at 130 C. in air for 120 hours or 504 hours.

(13) FIG. 13 shows the HTM by-products detected as a function of depth in ram extruded, vitamin E-blended, peroxide cross-linked UHMWPE before and after annealing at 80 C. in air or 80 C. in water for 18 hours.

(14) FIG. 14 shows a consolidation mold with curved surfaces.

DETAILED DESCRIPTION OF THE INVENTION

(15) This invention comprises methods of making oxidation and wear resistant polymeric materials using peroxide cross-linking and high temperature melting process. The invention also comprises a multiple step procedure for enabling the manufacturing of such material without size limitations.

Definitions

(16) The term additive refers to any material that can be added to a base polymer in less than 50 v/v %. This material can be an organic or inorganic material with a molecular weight less than that of the base polymer. An additive can impart different properties to the polymeric material, for example, it can be a nucleating agent, a cross-linking agent or an antioxidant.

(17) Peroxide initiation or decomposition temperature (T.sub.p): means the temperature at which the peroxide dissociates/decomposes substantially into free radicals which can initiate other reactions, for example at least 0.1%, more preferably at least 10%, or most preferably at least 50% within 1 hour into the free radical(s) that initiate cross-linking in the polymer. Organic peroxides are commonly characterized by their half-lives, i.e., the time it takes for half of a quantity of given peroxide in a given solution to decompose in 1 hour (T.sub.1) or 10 hours (T.sub.10). The peroxide initiation temperature, T.sub.p, is used generally interchangeably with decomposition temperature, which may be, for example, 5 C. or 10 C. below or 5 C. or 10 C. above the temperature corresponding to the half-life in 10 hours (T.sub.10) or to the half-life in 1 hour (T.sub.1). This difference may be because the presence of the peroxide in the polymer rather than that in solution. Peroxide initiation or decomposition temperature can be in the range from 20 C. to 500 C., preferably from 0 C. to 200 C., more preferably from 30 C. to 190 C. It can be 30 C., 35 C., 40 C., 45 C., 50 C., 55 C., 60 C., 65 C., 70 C., 75 C., 80 C., 85 C., 90 C., 95 C., 100 C., 105 C., 110 C., 115 C., 120 C., 125 C., 130 C., 135 C., 140 C., 145 C., 150 C., 155 C., 160 C., 165 C., 170 C., 175 C., 180 C., 185 C., 190 C., 195 C., 200 C., 205 C., 210 C., 215 C., 220 C., 225 C., 230 C., 235 C., 240 C., 245 C., 250 C., 255 C., 260 C., 265 C., 270 C., 275 C., 280 C., 285 C., 290 C., 295 C., 300 C., 305 C., 310 C., 315 C., or 320 C.

(18) Peroxides are a group of chemicals with the peroxide functional group. General peroxide categories include inorganic peroxides, organic peroxides, diacyl peroxides, peroxyesters, peoxydicarbonates, dialkyl peroxides, ketone peroxides, peroxyketals, cyclic peroxides, peroxymonocarbonatesand hydroperoxides. They contain an easily breakable OO bond that can dissociate/decompose into free radicals when heated and cause cross-linking in polyolefins; therefore peroxides are referred to as part of a family of cross-linking agents in this application. Peroxides in this invention can be selected from any peroxide, for example, benzoyl peroxide, dicumyl peroxide, methyl ethyl ketone peroxide, acetone peroxide, 2,5-Di(tert-butylperoxy)-2,5-dimethyl-3-hexyne (Luperox 130), 3,3,5,7,7-pentamethyl-1,2,4 trioxepane (Trigonox 311), etc. or mixtures thereof. Other examples of peroxides are dilauryl peroxide, methyl ether ketone peroxide, t-amyl peroxyacetate, t-butyl hydroperoxide, t-amyl peroxybenzoate, D-t-amyl peroxide, 2,5-Dimethyl 2,5-Di(t-butylperoxy)hexane, t-butylperoxy isopropyl carbonate, succinic acid peroxide, cumene hydroperoxide, 2,4-pentanedione peroxide, t-butyl perbenzoate, diethyl ether peroxide, acetone peroxide, arachidonic acid 5-hydroperoxide, carbamide peroxide, tert-butyl hydroperoxide, t-butyl peroctoate, t-butyl cumyl peroxide, Di-sec-butyl-peroxydicarbonate, D-2-ethylhexylperoxydicarbonate, 1,1-Di(t-butylperoxy)cyclohexane. Other examples of peroxides are members of the Luperox family supplied by Arkema. Other examples of peroxides are 1,1-Di(tert-butylperoxy)-3,3,5-trimethylcyclohexane, 2,5-Dimethyl-2,5-di(tert-butylperoxy)hexane, 3,3,5,7,7-Pentamethyl-1,2,4-trioxepane, Butyl 4,4-di(tert -butylperoxy)valerate, Di(2,4-dichlorobenzoyl) peroxide, Di(4-methylbenzoyl) peroxide, Di(tert-butylperoxyisopropyl)benzene, tert-Butyl cumyl peroxide, tert-Butyl peroxy-3,5,5-trimethylhexanoate, tert-Butyl peroxybenzoate, tert-Butylperoxy 2-ethylhexyl carbonate. Other examples of peroxides are members of the Trigonox or Perkadox family supplied by Akzo Nobel.

(19) A crosslinking agent is a compound which can cause cross-linking in polymeric materials. Most often, cross-linking of the polymer follows a trigger which initiates the cross-linking process. For example, in the case of peroxides, heating to a temperature where the peroxide decomposes into free radicals, which are then transferred onto the polymer and initiate recombination reactions causing cross-linking is required. In other cases, other stimuli may be used to trigger the reaction such as the application of ultraviolet light, heat, pressure or vacuum, contact with a particular solvent, or irradiation or combinations thereof. In some embodiments, the cross-linking agents used are those that are commercially available and may contain impurities. In some embodiments, the cross-linking agents may be 100% pure or less. In some embodiments, the cross-linking agents are 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% pure.

(20) The definition of crosslinking agent herein differs somewhat from what is known in the art. Typically, a crosslinking agent is defined as a compound which can chemically attach to two or more points on the polymeric material, creating a linkage between the same or different polymer chains. We are using a more general, expanded definition where the crosslinking agent is a compound that initiates the processes that leads to the crosslinking of the polymeric material and the compound may or may not itself chemically or ionically attach to the polymer. For instance, the cross-linking agent may have a free radical, which may abstract a hydrogen from the polymeric material, creating a free radical on the polymeric material; subsequently such free radicals on the polymeric material can react with each other to form a cross-link without chemically attaching the cross-linking agent to the polymeric material. The cross-linking agent may also form covalent or ionic bonding with one or more sites on the polymeric material, thereby causing grafting or cross-linking. In this case, the cross-linking agent becomes part of the cross-linked polymeric material. In some embodiments, there are unreacted cross-linking agent and/or the byproducts of the cross-linking agent in the polymeric material. In some embodiments these unreacted cross-linking agent and/or the byproducts of the cross-linking agent are partially or fully extracted from the polymeric material after cross-linking. This extraction, among other methods, can include solvent extraction, emulsified solvent extraction, heat extraction, supercritical fluid extraction, and/or vacuum extraction. For instance, in some embodiments supercritical carbon dioxide extraction is used. In other embodiments, extraction by placing the polymeric material under vacuum with or without heat is used. For instance, a cross-linking agent fo UHMWPE may be a peroxide.

(21) The term antioxidant refers to what is known in the art as (see, for example, WO 01/80778, U.S. Pat. No. 6,448,315). Alpha- and delta-tocopherol; propyl, octyl, or dedocyl gallates; lactic, citric, ascorbic, tartaric acids, and organic acids, and their salts; orthophosphates, lycopene, tocopherol acetate are generally known form of antioxidants. Antioxidants are also referred as free radical scavengers, include: glutathione, lipoic acid, vitamins such as ascorbic acid (vitamin C), vitamin B, vitamin D, vitamin-E, tocopherols (synthetic or natural, alpha-, gamma-, delta-), acetate vitamin esters, water soluble tocopherol derivatives, tocotrienols, water soluble tocotrienol derivatives; melatonin, carotenoids, including various carotenes, lutein, pycnogenol, glycosides, trehalose, polyphenols and flavonoids, quercetin, lycopene, lutein, selenium, nitric oxide, curcuminoids, 2-hydroxytetronic acid; cannabinoids, synthetic antioxidants such as tertiary butyl hydroquinone, 6-amino-3-pyrodinoles, butylated hydroxyanisole, butylated hydroxytoluene, ethoxyquin, tannins, propyl gallate, other gallates, Aquanox family; Irganox and Irganox B families including Irganox 1010, Irganox 1076, Irganox 1330; Irgafos family including Irgafos 168; phenolic compounds with different chain lengths, and different number of OH groups; enzymes with antioxidant properties such as superoxide dismutase, herbal or plant extracts with antioxidant properties such as St. John's Wort, green tea extract, grape seed extract, rosemary, oregano extract, mixtures, derivatives, analogues or conjugated forms of these. Antioxidants/free radical scavengers can be primary antioxidants with reactive OH or NH groups such as hindered phenols or secondary aromatic amines, they can be secondary antioxidants such as organophosphorus compounds or thiosynergists, they can be multifunctional antioxidants, hydroxylamines, or carbon centered radical scavengers such as lactones or acrylated bis-phenols. The antioxidants can be selected individually or used in any combination.

(22) Irganox, as described herein refers to a family of antioxidants manufactured by Ciba Specialty Chemicals. Different antioxidants are given numbers following the Irganox name, such as Irganox 1010, Irganox 1035, Irganox 1076, Irganox 1098, etc. Irgafos refers to a family of processing stabilizers manufactured by Ciba Specialty Chemicals. Irganox family has been expanded to include blends of different antioxidants with each other and with stabilizers from different families such as the Irgafos family. These have been given different initials after the Irganox name, for instance, the Irganox HP family are synergistic combinations of phenolic antioxidants, secondary phosphate stabilizers and the lactone Irganox HP-136. Similarly, there are Irganox B (blends), Irganox L (aminic), Irganox E (with vitamin E), Irganox ML, Irganox MD families. Herein we discuss these antioxidants and stabilizers by their tradenames, but other chemicals with equivalent chemical structure and activity can be used. Addition, these chemicals can be used individually or in mixtures of ant composition. Some of the chemical structures and chemical names of the antioxidants in the Irganox family are listed in Table 1.

(23) TABLE-US-00001 TABLE 1 Chemical names and structures of some antioxidants trademarked under the Irganox name. Tradename Chemical name Chemical Structure Irganox 1010 Tetrakis[methylene(3,5-di-tert- butylhydroxyhydrocinnamate)]methane Irganox 1035 Thiodiethylene bis[3-[3,5-di-tert- butyl-4-hydroxyphenyl]propionate] Irganox 1076 Octadecyl 3,5-di-tert-butyl-4- hydroxylhydrocinnamate Irganox 1098 N,N-hexane-1,6-diylbis(3-(3,5-di- tert-butyl-4- hydroxyphenylpropionamide)) Irganox 1135 Benzenepropanoic acid, 3,5-bis (1,1-dimethyl-ethyl)-4-hydroxy-.C7- C9 branched alkyl esters Irganox 1330 1,3,5-tris(3,5-di-tert-butyl-4- hydroxybenzyl)-2,4,6- trimethylbenzene Irganox 1520 Irganox 1726 2,4-bis(dodecylthiomethyl)-6- methylphenol Irganox 245 Triethylene glycol bis(3-tert-butyl-4- hydroxy-5-methylphenyl)propionate Irganox 3052 2,2-methylenebis(4-methyl-6-tert- butylphenol)monoacrylate Irganox 3114 1,3,5-TRis(3,5-di-tert-butyl-4- hydroxybenzyl)-1,3,5-triazine- 2,4,6(1H,3H,5H)-trione 0 Irganox 5057 Benzenamine, N-phenyl-, reaction products with 2,4,4- trimethylpentene Irganox 565 2,4-bis(octylthio)-6-(4-hydroxy-3,5- di-tert-butylanilino)-1,3,5-triazine Irganox HP-136 5,7-di-t-butyl-3-(3,4 di- methylphenyl)- 3H-benzofuran-2-one Irgafos 168 Tris(2,4-di-tert- butylphenyl)phospite

(24) The term blending generally refers to mixing of a polymeric material in its pre-consolidated form with an additive. If both constituents are solid, blending can be done by using other component(s) such as a liquid to mediate the mixing of the two components, after which the liquid is removed by evaporating. If the additive is liquid, for example -tocopherol, then the polymeric material can be mixed with large quantities of liquid. This high concentration blend can be diluted down to desired concentrations with the addition of lower concentration blends or virgin polymeric material without the additive to obtain the desired concentration blend. Or the polymeric material can be mixed with enough liquid additive to obtain the desired concentration in the polymeric material. In the case where an additive is also an antioxidant, for example vitamin E, or -tocopherol, then blended polymeric material is also antioxidant-doped.

(25) In one embodiment UHMWPE flakes are blended with -tocopherol; preferably the UHMWPE/-tocopherol blend is heated to diffuse the -tocopherol into the flakes. This blend is then subjected to further treatment such as partial or complete molding and heat treatment.

(26) In some embodiments the cross-linking agent(s) and antioxidant(s) are blended together to form a cross-linking agent/antioxidant blend. The said cross-linking agent/antioxidant blend is then blended with polymeric material to obtain a polymeric material/cross-linking agent/antioxidant blend.

(27) The term consolidation refers generally to processes used to convert the polymeric material resin, particles, flakes, i.e. small pieces of polymeric material into a mechanically integral large-scale solid form, which can be further processed, by for example machining in obtaining articles of use such as medical implants. Methods such as injection molding, extrusion, compression molding, iso-static pressing (hot or cold), etc. can be used. In the present invention the pre-molded green polymeric material is poorly consolidated; that is the consolidation is not taken to its full extent. In the case of the green, the green also has porosity more than what is present in well-functioning medical implants made from the same polymeric material.

(28) In the case of UHMWPE, consolidation is most often performed by compression molding. In some instances consolidation can be interchangeably used with compression molding. The molding process generally involves: i. heating the polymeric material to be molded, ii. pressurizing the polymeric material while heated, iii. keeping at temperature and pressure, and iv. cooling down and releasing pressure.

(29) Heating of the polymeric material can be done at any rate. Temperature can be increased linearly with time or in a step-wise fashion or at any other rate. Alternatively, the polymeric material can be placed in a pre-heated environment. The mold for the consolidation can be heated together or separately from the polymeric material to be molded. Steps (i) and (ii), i.e. heating and pressurizing before consolidation can be done in multiple steps and in any order.

(30) For example, polymeric material can be pressurized at room temperature to a set pressure level 1, after which it can be heated and pressurized to another pressure level 2, which still may be different from the pressure or pressure(s) in step (iii). Step (iii), where a high temperature and pressure are maintained is the dwell period where a major part of the consolidation takes place. One temperature and pressure or several temperatures and pressures can be used during this time without releasing pressure at any point. For example, dwell temperatures in the range of 135 to 350 C. and dwell pressures in the range of 0.1 MPa to 100 MPa or up to 1000 MPa can be used. The dwell time can be from 1 minute to 24 hours, more preferably from 2 minutes to 1 hour, most preferably about 10 minutes. The temperature(s) at step (iii) are termed dwell or molding temperature(s). The pressure(s) used in step (iii) are termed dwell or molding pressure(s). The order of cooling and pressure release (step iv) can be used interchangeably. In some embodiments the cooling and pressure release may follow varying rates independent of each other. In some embodiments, consolidation of polymeric resin or blends of the resin with additive(s) are achieved by compression molding. The dwell temperature and dwell time for consolidation can be changed to control the amount of integration.

(31) In this invention, we also describe partial consolidation or partially consolidated or pre-molded polymeric material, which refers to a state of the polymeric material which is less integrated than a completely consolidated form of the polymeric material. The extent of integration can be quantified, for example, by measuring the elongation at break of the polymeric materials after consolidation. In general, a lower elongation at break indicates a less integrated or less consolidated state for the same type of polymeric resin. In general, a partially consolidated polymeric material may not have the required properties to be used as a final product and needs to be further integrated or processed or consolidated to increase its state of consolidation and/or to reduce its porosity. In pre-molding, temperature and pressure steps can be applied separately. Also in pre-molding, ambient pressure, partial pressure below ambient to reduce oxygen concentration, or vacuum can be used. Also the pre-molding step can be performed in air or in inert gas or a mixture thereof. The inert gas can be argon, helium, nitrogen or a mixture thereof. For example, dwell temperatures in the range of 0 C. to 350 C. and dwell pressures in the range of 0.001 MPa to 100 MPa or up to 1000 MPa can be used. The dwell time can be from 1 minute to 24 hours, more preferably from 2 minutes to 1 hour, most preferably about 5 minutes.

(32) Compression molding can also be done by layered molding. This refers to consolidating a polymeric material by compression molding one or more of its pre-molded and resin forms, which may be in the form of flakes, powder, pellets or the like or consolidated or pre-molded forms in layers. This may be done such that there can be distinct regions in the consolidated form containing different concentrations of additives such as antioxidant(s) or crosslinking agent(s). Whenever a layered-molded polymeric material is described in the examples below and is used in any of the embodiments, it can be fabricated by: (a) layered molding of a pre-molded polymeric material with polymeric resin powder or its antioxidant/crosslinking agent blends where one or more layers contain no crosslinking agent(s) and one or more layers contain one or more additives; (b) molding together of pre-molded layers of polymeric material containing different or identical concentration of additives such as antioxidant(s) and crosslinking agent(s).

(33) One or more of the layers can be treated before or during molding by heating, or high temperature melting. The layer or layers to be molded can be heated in liquid(s), in water, in air, in inert gas, in supercritical fluid(s) or in any environment containing a mixture of gases, liquids or supercritical fluids before pressurization. The layer or layers can be pressurized individually at room temperature or at an elevated temperature below the melting point or above the melting point before being molded together. The temperature at which the layer or layers are pre-heated can be the same or different from the molding or dwell temperature(s). The temperature can be gradually increased from pre-heat to mold temperature with or without pressure. The pressure to which the layers are exposed before molding can be gradually increased or increased and maintained at the same level.

(34) During consolidation, different regions of the mold can be heated to different temperatures. The temperature and pressure can be maintained during molding for 1 second up to 1000 hours or longer. During cool-down under pressure, the pressure can be maintained at the molding pressure or increased or decreased. The cooling rate can be 0.0001 C./minute to 120 C./minute or higher. The cooling rate can be different for different regions of the mold. After cooling down to about room temperature, the mold can be kept under pressure for 1 second to 1000 hours. Or the pressure can be released partially or completely at an elevated temperature.

(35) In some embodiments, the consolidated polymeric material is fabricated through direct compression molding (DCM), which is compression molding using parallel plates or any plate/mold geometry which can directly result in an implant or implant preform. Preforms are generally oversized versions of implants, where some machining of the preform can give the final implant shape. In some embodiments certain features of the final implant shape may be machined after direct compression molding.

(36) In some embodiments, the pre-molded polymeric material is subjected to high temperature melting and subsequently direct compression molded. The direct compression molded polymeric material may be in its final implant shape. In some embodiments certain features of the final implant shape may be machined after direct compression molding. In certain embodiments, the pre-molded polymeric material contains cross-linking agents. In some embodiments the pre-molded polymeric material is subjected to irradiation before the subsequent direct compression molding.

(37) Compression molding can also be done such that the polymeric material is directly compression molded onto a second surface, for example a metal or a porous metal to result in an implant or implant preform. This type of molding results in a hybrid interlocked polymeric material or hybrid interlocked medical implant preform or hybrid interlocked medical implant. Molding can be conducted with a second piece, for example a metal, that becomes an integral part of the consolidated polymeric article. For example, a combination of antioxidant-containing polyethylene resin, powder, or flake and virgin polyethylene resin, powder or flake is direct compression molded into a metallic acetabular cup or a tibial base plate. The porous tibial metal base plate is placed in the mold, antioxidant blended polymeric resin, powder, or flake is added on top. Prior to consolidation, the pores of the metal piece can be filled with a waxy or plaster substance through half the thickness to achieve polyethylene interlocking through the other unfilled half of the metallic piece. The pore filler is maintained through the irradiation and subsequent processing (for example peroxide diffusion) to prevent infusion of components in to the pores of the metal.

(38) In some embodiments, the article is machined after processing to shape an implant. In some embodiments, there is more than one metal piece integral to the polymeric article. The metal(s) may be porous only in part or non-porous. In another embodiment, one or some or all of the metal pieces integral to the polymeric article is a porous metal piece that allows bone in-growth when implanted into the human body. In one embodiment, the porous metal of the implant is sealed using a sealant to prevent or reduce the infusion of antioxidant/peroxide (in diffusion steps after consolidation) into the pores during the selective doping of the implant. Preferably, the sealant is water soluble. But other sealants are also used. The final cleaning step that the implant is subjected to also removes the sealant. Alternatively, an additional sealant removal step is used. Such sealants as water, saline, aqueous solutions of water soluble polymers such as poly-vinyl alcohol, water soluble waxes, plaster of Paris, or others are used. In addition, a photoresist like SU-8, or other, may be cured within the pores of the porous metal component. Following processing, the sealant may be removed via an acid etch or a plasma etch. In these embodiments, the polymeric material, which is molded directly onto a second surface to form the hybrid interlocked polymeric material, maybe a pre-molded polymeric material with or without additives and/or cross-linking agents. In such embodiments the pre-molded polymeric material may be subjected to high temperature melting and/or radiation cross-linking.

(39) The term cross-linking refers to what is known in the art as processes that result in the covalent bonding of the parts of a material, for example polymer chains in a polymeric material. In the case of UHMWPE, which is a semi-crystalline polymer, there is covalent bonding of the polymer chains of the polymeric material. For instance, the cross-link density of polyolefins, such as polyethylene is measured by swelling a roughly 333 mm cube of polymeric material in xylene. The samples are weighed before swelling in xylene at 130 C. for 2 hours and they are weighed immediately after swelling in xylene. The amount of xylene uptake is determined gravimetrically, then converted to volumetric uptake by dividing by the density of xylene; 0.75 g/cc. By assuming the density of polyethylene to be approximately 0.94 g/cc, the volumetric swell ratio of cross-linked UHMWPE is then determined. The cross-link density is calculated by using the swell ratio as described in Oral et al., Biomaterials 31: 7051-7060 (2010) and is reported in mol/m.sup.3. The term highly cross-linked refers generally to the state of the polymeric material where there is further cross-linking and the cross-link density is higher than that of substantially cross-linked polymeric material. The term cross-linked refers to the state of polymeric material that is cross-linked to any level, for instance substantial cross-linked or highly cross-linked states.

(40) The term wear refers to the removal of material from the polymeric material during articulation or rubbing against another material. For UHMWPE, wear is generally assessed gravimetrically after an initial creep deformation allowance in number of cycles of motion. The term wear resistant refers to the state of a polymeric material where it has low wear. For example, the wear rate is tested on cylindrical pins (diameter 9 mm, length 13 mm) on a bidirectional pin-on-disc wear tester in undiluted bovine calf serum at 2 Hz in a rectangular pattern (5 mm10 mm) under variable load with a maximum of 440 lbs as described in Bragdon et al. (J Arthroplasty 16: 658-665 (2001)). Initially, the pins are subjected to 0.5 million cycles (MC), after which they are tested to 1.25 million cycles with gravimetric measurements approximately every 0.125 MC. The wear rate is determined by the linear regression of the weight loss as a function of number of cycles from 0.5 to 1.25 MC. The term highly wear resistant refers to the state of a polymeric material with a wear rate of less than 3 mg/million-cycles under these conditions.

(41) The term surface of a polymeric material refers generally to the exterior region of the material having a thickness of about 1.0 m to about 2 cm or more, preferably about 1.0 mm to about 5 mm, more preferably about 2 mm of a polymeric material or a polymeric sample or a medical device comprising polymeric material. Surface may also refer to multiple regions in the exterior of the polymeric material.

(42) The term bulk of a polymeric material refers generally to an interior region of the material having a thickness of about 1.0 m to about 2 cm or more, preferably about 1.0 mm to about 5 mm, more preferably about 2 mm, from the surface of the polymeric material to the center of the polymeric material. However, the bulk may include selected sides or faces of the polymeric material including any selected surface.

(43) Although the terms surface and bulk of a polymeric material generally refer to exterior regions and the interior regions, respectively, there generally is no discrete boundary between the two regions. But, rather the regions are more of a gradient-like transition. These can differ based upon the size and shape of the object and the resin used.

(44) The term doping refers to a process known in the art (see, for example, U.S. Pat. Nos. 6,448,315 and 5,827,904). In this connection, doping generally refers to contacting a polymeric material with a component or the solution/emulsion of a component under certain conditions, as set forth herein, for example, doping UHMWPE with an antioxidant under supercritical conditions. Doping also refers to introducing additive(s) into the base polymeric material in quantities less than 50 v/v %. A polymeric material treated in such a way, for example, to incorporate an antioxidant is termed as an antioxidant-doped polymeric material. The polymeric material can be doped by other additives as well, such as a crosslinking agent, in which case the polymeric material treated in such a way may be termed as crosslinking agent-doped polymeric material. Alternatively, if the polymeric material is doped by one or more peroxides, it may be termed peroxide-doped polymeric material.

(45) Doping may also be done by diffusing an additive into the polymeric material by immersing the polymeric material in additive, by contacting the polymeric material with additive in the solid state, by contacting the polymeric material with a bath of additive in the liquid state, or by contacting the polymeric material with a mixture of the additive in one or more solvents in solution, emulsion, suspension, slurry, aerosol form, or in a gas or in a supercritical fluid. The doping process by diffusion can involve contacting a polymeric material, a preform, medical implant or device with an additive, such as 2,5-dimethyl-2,5-Di-(t-butylperoxy)hexyne-3 (Luperox 130), for about an hour up to several days, preferably for about one hour to 24 hours, more preferably for one hour to 16 hours. The doping time can be from a second to several weeks, or it can be 1 minute to 24 hours, or it can be 15 minutes to 24 hours in 15 minute intervals. The medium for the diffusion of the additive (bath, solution, emulsion, paste, slurry and the like) can be heated to room temperature or up to about 200 C. or more and the doping can be carried out at room temperature or up to about 200 C. or more. Preferably, the antioxidant can be heated to 100 C. and the doping is carried out at 100 C. Or the doping can be carried out at 20 C. 25 C., 30 C., 35 C., 40 C., 45 C., 50 C., 55 C., 60 C., 65 C., 70 C., 75 C., 80 C., 85 C., 90 C., 95 C., 100 C., 105 C., 110 C., 115 C., 120 C., 125 C., 130 C., 135 C., 140 C., 145 C., 150 C., 155 C., 160 C., 165 C., 170 C., 175 C., 180 C., 185 C., 190 C., 195 C., 200 C., 205 C., 210 C., 215 C., 220 C., 230 C., 240 C., 250 C., 260 C., 270 C., 280 C., 290 C., 300 C., 320 C. or 340 C.

(46) The doped polymeric material can be annealed (heated) by heating below or above the melting point of the polymeric material subsequent to doping. The annealing is preferably for about an hour up to several days, more preferably for about one hour to 24 hours, most preferably for one hour to 16 hours. The doping time can be from a second to several weeks, or it can be 1 minute to 24 hours, or it can be 15 minutes to 24 hours in 15 minute intervals. The doped polymeric material can be heated to room temperature or up to about 350 C. and the annealing can be carried out at room temperature or up to about 350 C. Preferably, the doped polymeric material can be heated to 120 C. and the annealing is carried out at 120 C. Or annealing can be carried out at 20 C., 25 C., 30 C., 35 C., 40 C., 45 C., 50 C., 55 C., 60 C., 65 C., 70 C., 75 C., 80 C., 85 C., 90 C., 95 C., 100 C., 105 C., 110 C., 115 C., 120 C., 125 C., 130 C., 135 C., 140 C., 145 C., 150 C., 155 C., 160 C., 165 C., 170 C., 175 C., 180 C., 185 C., 190 C., 195 C., 200 C., 205 C., 210 C., 215 C., 220 C., 225 C., 230 C., 235 C., 240 C., 245 C., 250 C., 255 C., 260 C., 265 C., 270 C., 275 C., 280 C., 285 C., 290 C., 295 C., 300 C., 315 C., 320 C., 325 C., 330 C., 335 C. or 340 C. In the case of a peroxide-doped polymeric material, annealing can cause cross-linking if the temperature(s) used during annealing is close to or above the peroxide initiation temperature(s). Annealing can be performed in liquid(s), in air, in other gases such as oxygen, in inert gas, in supercritical fluid(s), in a sensitizing environment or in vacuum. Annealing can also be performed in ambient pressure, above ambient pressure, or below ambient pressure. Annealing can also be performed while the polymeric material is immersed in liquid antioxidant, such as vitamin E, or a solution/emulsion of antioxidant(s).

(47) A sensitizing environment or sensitizing atmosphere refers to a mixture of gases and/or liquids (at room temperature) that contain sensitizing gases and/or liquid component(s) that can react with residual free radicals to assist in the recombination of the residual free radicals. The gases maybe acetylene, chloro-trifluoro ethylene (CTFE), ethylene, or like. The gases or the mixtures of gases thereof may contain noble gases such as nitrogen, argon, neon and like. Other gases such as, carbon dioxide or carbon monoxide may also be present in the mixture. In applications where the surface of a treated material is machined away during the device manufacture, the gas blend could also contain oxidizing gases such as oxygen. The sensitizing environment can be dienes with different number of carbons, or mixtures of liquids and/or gases thereof. An example of a sensitizing liquid component is octadiene or other dienes, which can be mixed with other sensitizing liquids and/or non-sensitizing liquids such as a hexane or a heptane. A sensitizing environment can include a sensitizing gas, such as acetylene, ethylene, or a similar gas or mixture of gases, or a sensitizing liquid, for example, a diene. The environment is heated to a temperature ranging from room temperature to a temperature below the melting point of the material.

(48) In certain embodiments of the present invention in which the sensitizing gases and/or liquids or a mixture thereof, inert gas, air, vacuum, and/or a supercritical fluid can be present at any of the method steps disclosed herein, including blending, mixing, consolidating, quenching, irradiating, annealing, mechanically deforming, doping, homogenizing, heating, melting, and packaging of the finished product, such as a medical implant.

(49) The term free radical initiator refers to what is known in the art as substances which can yield radical species under certain conditions, for example, by heating. They generally possess bonds that can easily dissociate. For example, peroxide(s) contain easily breakable OO bonds.

(50) The term nucleating agent refers to an additive known in the art, an organic or inorganic material with a molecular weight less than that of the base polymer, which increases the rate of crystallization in the polymeric material. Typically, organocarboxylic acid salts, for example calcium carbonate, are good nucleation agents for polyolefins. Also, nucleating agents are typically used in small concentrations such as 0.5 wt %.

(51) The term crystallinity refers to the fraction of the polymer that is crystalline. The crystallinity is calculated by knowing the weight of the sample (weight in grams), the heat absorbed by the sample in melting (E, in J/g) and the heat of melting of polyethylene crystals (H=291 J/g), and using the following equation according to ASTM F2625 and the like or their successors:
% Crystallinity=E/w.Math.H

(52) The term peak melting temperature refers to what is known in the art as the melting transition of a polymeric material, where the material goes to a transition from a solid to a melt state. In a semi-crystalline material such as UHMWPE, this transition can overlap with the melting temperature of its crystalline portion. It can be determined using a differential scanning calorimeter at a heating rate of 10 C./min from 20 C. to 200 C. The peak melting temperature for UHMWPE is generally about 136 to about 140 C., or can be about 144 to about 147 C. if it contains extended chain crystals.

(53) The term non-permanent device refers to what is known in the art as a device that is intended for implantation in the body for a period of time shorter than several months. Some non-permanent devices could be in the body for a few seconds to several minutes, while other may be implanted for days, weeks, or up to several months. Non-permanent devices include catheters, tubing, intravenous tubing, and sutures, for example.

(54) The term packaging refers to the container or containers in which a medical device is packaged and/or shipped. Packaging can include several levels of materials, including bags, blister packs, heat-shrink packaging, boxes, ampoules, bottles, tubes, trays, or the like or a combination thereof. A single component may be shipped in several individual types of package, for example, the component can be placed in a bag, which in turn is placed in a tray, which in turn is placed in a box. The whole assembly can be sterilized and shipped. The packaging materials include, but not limited to, vegetable parchments, multi-layer polyethylene, Nylon 6, polyethylene terephthalate (PET), and polyvinyl chloride-vinyl acetate copolymer films, polypropylene, polystyrene, and ethylene-vinyl acetate (EVA) copolymers.

(55) The term medical implant refers to a medical device made for the purpose of implantation in a living body, for example and animal or human body. The medical implants include but are not limited to acetabular liners, tibial insert, glenoid component, patellar components, and other load-bearing, articular components used in total joint surgery. The term permanent device refers to what is known in the art that is intended for implantation in the body for a period longer than several months. Permanent devices include medical implants or devices, for example, acetabular liner, shoulder glenoid, patellar component, finger joint component, ankle joint component, elbow joint component, wrist joint component, toe joint component, bipolar hip replacements, tibial knee insert, tibial knee inserts with reinforcing metallic and polyethylene posts, intervertebral discs, sutures, tendons, heart valves, stents, and vascular grafts. The term medical implant refers to what is known in the art as a device intended for implantation in animals or humans for short or long term use. The medical implants, according to an aspect of the invention, comprises medical devices including acetabular liner, shoulder glenoid, patellar component, finger joint component, ankle joint component, elbow joint component, wrist joint component, toe joint component, bipolar hip replacements, tibial knee insert, tibial knee inserts with reinforcing metallic and polyethylene posts, intervertebral discs, sutures, tendons, heart valves, stents, and vascular grafts.

(56) What is meant by room temperature is between 15 C. and 30 C.

(57) What is meant by virgin is a material with no additives. For instance virgin polymeric material is a polymeric material with no additives such as antioxidants or cross-linking agents.

(58) The term interface in this invention is defined as the niche in medical devices formed when an implant is in a configuration where a component is in contact with another piece (such as a metallic or a non-metallic component), which forms an interface between the polymer and the metal or another polymeric material. For example, interfaces of polymer-polymer or polymer-metal are in medical prosthesis, such as orthopedic joints and bone replacement parts, for example, hip, knee, elbow or ankle replacements.

(59) Medical implants containing factory-assembled pieces that are in close contact with the polyethylene form interfaces. In most cases, the interfaces are not readily accessible to ethylene oxide gas or the gas plasma during a gas sterilization process.

(60) Polymeric materials or polymer include polyethylene, for example, Ultra-high molecular weight polyethylene (UHMWPE) refers to linear non-branched chains of ethylene having molecular weights in excess of about 500,000, preferably above about 1,000,000, and more preferably above about 2,000,000. Often the molecular weights can reach about 8,000,000 or more. By initial average molecular weight is meant the average molecular weight of the UHMWPE starting material, prior to any irradiation. See U.S. Pat. No. 5,879,400, PCT/US99/16070, filed on Jul. 16, 1999, and PCT/US97/02220, filed Feb. 11, 1997. The term polyethylene article or polymeric article or polymer generally refers to articles comprising any polymeric material disclosed herein.

(61) The term polymeric materials or polymer also include hydrogels, such as poly (vinyl alcohol), poly (acrylamide), poly (acrylic acid), poly(ethylene glycol), blends thereof, or interpenetrating networks thereof, which can absorb water such that water constitutes at least 1 to 10,000% of their original weight, typically 100 wt % of their original weight or 99% or less of their weight after equilibration in water.

(62) Polymeric material or polymer can be in the form of resin, flakes, powder, consolidated stock, implant, and can contain additives such as antioxidant(s). The polymeric material or polymer also can be a blend of one or more of different resin, flakes or powder containing different concentrations of an additive such as an antioxidant. The blending of resin, flakes or powder can be achieved by the blending techniques known in the art. The polymeric material also can be a consolidated stock of these blends.

(63) Polymeric materials or polymers can also include structural subunits different from each other. Such polymers can be di- or tri- or multiple unit-copolymers, alternating copolymers, star copolymers, brush polymers, grafted copolymers or interpenetrating polymers. They can be essentially solvent-free during processing and use such as thermoplastics or can include a large amount of solvent such as hydrogels. Polymeric materials also include synthetic polymers, natural polymers, blends and mixtures thereof. Polymeric materials also include degradable and non-degradable polymers.

(64) The products and processes of this invention also apply to various types of polymeric materials, for example, any polypropylene, any polyamide, any polyether ketone, or any polyolefin, including high-density-polyethylene, low-density-polyethylene, linear-low-density-polyethylene, ultra-high molecular weight polyethylene (UHMWPE), copolymers or mixtures thereof. The products and processes of this invention also apply to various types of hydrogels, for example, poly(vinyl alcohol), poly(ethylene glycol), poly(ethylene oxide), poly(acrylic acid), poly(methacrylic acid), poly(acrylamide), copolymers or mixtures thereof, or copolymers or mixtures of these with any polyolefin. Polymeric materials, as used herein, also applies to polyethylene of various forms, for example, resin, powder, flakes, particles, powder, or a mixture thereof, or a consolidated form derived from any of the above. Polymeric materials, as used herein, also applies to hydrogels of various forms, for example, film, extrudate, flakes, particles, powder, or a mixture thereof, or a consolidated form derived from any of the above.

(65) The term sterile refers to a condition of an object, for example, an interface or a hybrid material or a medical implant containing interface(s), wherein the interface is sufficiently sterile to be medically acceptable, i.e., will not cause an infection or require revision surgery. The object, for example a medical implant, can be sterilized using ionizing radiation or gas sterilization techniques. Gamma sterilization is well known in the art. Electron beam sterilization is also used. Ethylene oxide gas sterilization and gas plasma sterilization are also used. Autoclaving is another method of sterilizing medical implants. Exposure to solvents or supercritical fluids for sufficient to kill infection-causing microorganisms and/or their spores can be a method of sterilizing.

(66) The terms about or approximately in the context of numerical values and ranges refers to values or ranges that approximate or are close to the recited values or ranges such that the invention can perform as intended, such as utilizing a method parameter (e.g., time, dose, dose rate/level, and temperature), having a desired degree of cross-linking and/or a desired lack of or quenching of free radicals, as is apparent to the skilled person from the teachings contained herein. This is due, at least in part, to the varying properties of polymer compositions. Thus, these terms encompass values beyond those resulting from systematic error. These terms make explicit what is implicit, as known to the person skilled in the art.

(67) All ranges set forth herein in the summary and description of the invention include all numbers or values thereabout or therebetween of the numbers of the range. The ranges of the invention expressly denominate and set forth all integers, decimals and fractional values in the range. For example, the radiation dose can be about 50 kGy, about 65 kGy, about 75 kGy, about 100 kGy, about 200 kGy, about 300 kGy, about 400 kGy, about 500 kGy, about 600 kGy, about 700 kGy, about 800 kGy, about 900 kGy, or about 1000 kGy, or above 1000 kGy, or any integer, decimal or fractional value thereabout or therebetween.

(68) The term heating refers to bringing a material to a temperature, generally a temperature above that of its current state. It can also refer to maintaining said temperature for a period of time, that is, in some instances it can be used interchangeably with annealing. Heating can be done at any rate. The heating rate can be from 0.001 C./min to 1000 C./min, or it can be between 0.1 C./min to 100 C./min, or it can be from 0.5 C./min to 10 C./min, or it can be any rate from 1 C./min to 50 C./min in 1 C. intervals. The heating can be done for any duration. Heating time can be from 0.1 minutes to 100 years, or from 1 minute to 24 hours, or from 1 minute to 12 hours, or 30 minutes to 10 hours, or 5 hours, or 6 hours, or 8 hours.

(69) The term cooling refers to bringing a material to a temperature, generally a temperature below that of its current state. It can also refer to maintaining said temperature for a period of time, that is, in some instances it can be used interchangeably with annealing. Cooling can be done at any rate. The cooling rate can be from 0.001 C./min to 1000 C./min, or it can be between 0.1 C./min to 100 C./min, or it can be from 0.5 C./min to 10 C./min, or it can be any rate from 1 C./min to 50 C./min in 1 C. intervals, or 2.5 C./min. The cooling can be done for any duration. Cooling time can be from 0.1 minutes to 100 years, or from 1 minute to 24 hours, or from 1 minute to 12 hours, or 30 minutes to 10 hours, or 1 hours, or 2 hours, or 5 hours, or 6 hours, or 8 hours.

(70) The term annealing refers to bringing a material to a temperature and maintaining at that temperature. In the art, it can refer generally to heating a material below its melting point and maintaining at that temperature for a period of time. In this application, it refers to heating or cooling to any temperature below or above the melting temperature of a material, for example a polymeric material. Heating/cooling can be done at any rate. The heating/cooling rate can be from 0.001 C./min to 1000 C./min, or it can be between 0.1 C./min to 100 C./min, or it can be from 0.5 C./min to 10 C./min, or it can be any rate from 1 C./min to 50 C./min in 1 C. intervals. The annealing can be done for any duration. Annealing time can be from 0.1 minutes to 100 years, or from 1 minute to 24 hours, or from 1 minute to 12 hours, or 30 minutes to 10 hours, or 5 hours, or 6 hours, or 8 hours.

(71) The term high temperature melting refers to heating a material to temperatures preferably above 200 C. It can also refer to maintaining said temperature for a period of time, that is, in some instances it can be used interchangeably with annealing. Heating can be done at any rate. The heating rate can be from 0.001 C./min to 1000 C./min, or it can be between 0.1 C./min to 100 C./min, or it can be from 0.5 C./min to 10 C./min, or it can be any rate from 1 C./min to 50 C./min in 1 C. intervals. The heating can be done for any duration. Heating time can be from 0.1 minutes to 100 years, or from 1 minute to 24 hours, or from 1 minute to 12 hours, or 30 minutes to 10 hours, or 5 hours, or 6 hours, or 8 hours. During heating the material is kept at a certain temperature. There may be fluctuations in temperature during heating. The fluctuations may be as little as less than 1 or as large as several tens of degrees or more.

(72) The term irradiation refers to what is known in the art as exposing a material to radiation, for example ionizing radiation such as a gamma, electron, X-ray or ultraviolet (UV) radiation. Radiation cross-linking refers to a radiation process intended to cross-link a material as a result of irradiation, for example exposing UHMWPE to gamma irradiation to cross-link the material. It also refers to the cross-linking in the material that has resulted from a radiation process. The radiation dose used can be from 0.0001 kGy to 100000 kGy, or 0.1 kGy to 1000 kGy, or from 1 kGy to 300 kGy, or about 100 kGy, or about 150 kGy, or about 175 kGy, or about 200 kGy. The radiation dose rate can be from 0.001 kGy/min to 100000 kGy/min, or from 0.1 kGy/min to 100 kGy/min, or from 1 kGy/min to 50 kGy/min, or about 25 kGy/min, or about 10 kGy/min, or about 100 kGy/min. Irradiation can be done in air, in vacuum, or partial gas environments, for example mixtures of oxygen and nitrogen. It can also be done in inert gas or partial inert gas. It can also be done at ambient temperature, or below or above ambient temperature. It can be done at elevated temperatures above ambient temperature. Irradiation temperature can be from 100 C. to 1000 C., or from 0 C. to 500 C., or from 20 C. to 200 C., or from 25 C. to 150 C., or at about 25 C., or about 70 C., or about 100 C., or about 120 C., or about 125 C.

(73) In any of the embodiments, cross-linking agent (peroxide) cross-linking, high temperature melting and their associated processes can be performed as in U.S. Patent Application No. 61/620,202, filed Apr. 4, 2012, and U.S. Provisional Patent Application No. 61/756,595, filed Jan. 25, 2013, and U.S. Provisional Patent Application No. 61/794,284, filed Mar. 15, 2013, which are incorporated in their entirety as reference.

(74) In any of the embodiments, the preparation of the polymeric material, high temperature melting and its associated processes can be performed as in U.S. Patent Publication No. 61/154134, which is incorporated in its entirety as reference.

(75) In any of the embodiments, the preparation of the polymeric material, radiation cross-linking and its associated processes can be performed as in U.S. Pat. No. 5,879,400 and U.S. Pat. No. 6,786,933, which are incorporated in their entirety as reference.

(76) In any of the embodiments, the preparation of the polymeric material, antioxidant addition to the polymeric material or radiation crosslinking can be performed as in U.S. Pat. No. 7,431,874, which is incorporated in its entirety as reference.

(77) In any of the embodiments, the preparation of the polymeric material, antioxidant addition to the polymeric material, radiation crosslinking, or the consolidation and post-consolidation processing can be performed as in U.S. Pat. No. 8,426,486 and U.S. Pat. No. 8,425,815, which are incorporated in their entirety as reference.

(78) Blending of Resin

(79) In some embodiments, one or more additives are added to the polymeric material by mixing with the polymeric resin. These additives can be added sequentially or at the same time. They can also be added with the aid of a mixing agent such as a solvent. For example, an antioxidant (AO) or a mixture of AOs (e.g. vitamin E) can be blended into UHMWPE polymeric powder using isopropyl alcohol (IPA) to aid in mixing. AO is dissolved in IPA, then mixed with UHMWPE resin powder. For example the mixing is carried out in an industrial blender, whereby the UHMWPE is placed in the blender and while the blender is in action, tumbling the UHMWPE powder, the antioxidant or the antioxidant solution (for example in IPA) is injected either all at once or intermittently to achieve the desired antioxidant concentration in the final blend. Vacuum and/or heating can be used to aid in the evaporation of the solvent during or after mixing. An organic peroxide or a mixture of organic peroxides can be introduced in pure form or with the aid of a mixing agent such as a solvent together with an antioxidant or a mixture of AOs (e.g. Vitamin E) or separately. For example, a vitamin E-blended UHMWPE powder can further be mixed with peroxide 130 in pure form by injecting through the same port or in other port in the industrial blender. Alternatively, both vitamin E and P130 can be dissolved in IPA before mixing with UHMWPE resin powder. The blending of UHMWPE with the peroxide(s) or AO(s) can be carried out by adding these respective additives in any order or altogether.

(80) Blending of any additives into the polymeric material can be done under vacuum, partial vacuum, atmospheric pressure or in a pressurized environment. The blending can be in contact with inert gas, reactive gas, oxygen, or any combination thereof. Blending can also be performed in fluids such as supercritical fluids. These environments can be continuous, sequential or alternating in any desired sequence. Blending can also be done under heating or cooling, spontaneously or externally. The temperature during the blending of additives with polymeric material can be from 100 C. to 500 C., more preferably 25 C. to 120 C., more preferably 25 C. to 90 C., most preferably about 25 C. to 80 C. Active cooling or heating can be applied during blending to maintain temperature in the desired range or ranges. The temperature during blending can also be varied in the form of heating, cooling, or soaking at a temperature as desired.

(81) In some embodiments blending of additives with polymeric resin can be done to achieve a final desired blend concentration. Alternatively master batches or concentrated forms of additive-mixed polymeric resin blends can be used. For example, if a 0.2 wt % vitamin E blend of UHMWPE is desired, this blend can be directly mixed to 0.2 wt % vitamin E concentration; alternatively a more concentrated vitamin E/UHMWPE blend can be made (such as a 2 wt % vitamin E/UHMWPE master batch) to be later diluted down by adding virgin UHMWPE or vitamin E/UHMWPE blend with lower vitamin E concentration blend to achieve the final desired blend concentration.

(82) For example a 2 wt % vitamin E/UHMWPE blend can be mixed with virgin UHMWPE with no additives to obtain a lower vitamin E concentrated blend. The same can be done by adding a lower vitamin E concentration blend to the 2 wt % vitamin E/UHMWPE master batch instead of the virgin UHMWPE. The addition of peroxide(s) can be done during the said dilution step. The master batch and/or the virgin/lower concentration blends could be mixed (separately or together) with organic peroxide(s).

(83) Cross-linking agent definition also includes carbon-carbon initiators, which can also initiate cross-linking in polymeric material similar to peroxides. Some examples of this group of compounds are 2,3-dimethyl-2,3-diphenylbutane or poly-1,4-diisopropylbenzene. Cross-linking agent may be a peroxide or a carbon-carbon initiator or a mixture thereof.

(84) The polymeric material can be blended with additives in any quantity desired, for example 20 kilograms or more of polymeric material resin can be blended with additives using industrial blenders. After blending, the blended-polymeric material can be stored under vacuum, partial vacuum, atmospheric pressure or a pressurized environment. Inert gas, air, oxygen, reactive gas, or a combination thereof can be used as storage environment. The polymeric material can be stored at a temperature from 100 C. to 500 C., preferably from 20 C. to 30 C., most preferably from 20 C. to 4 C. Storing the blended polymeric material at temperatures below room temperature in closed or sealed containers can minimize the loss of any additives to evaporation.

(85) High Temperature Melting Process

(86) The term high temperature melting refers to heating a material to temperatures preferably above 200 C. It can also refer to maintaining said temperature for a period of time, that is, in some instances it can be used interchangeably with annealing. Heating can be done at any rate. The heating rate can be from 0.001 C./min to 1000 C./min, or it can be between 0.1 C./min to 100 C./min, or it can be from 0.5 C./min to 10 C./min, or it can be any rate from 1 C./min to 50 C./min in 1 C. intervals. The heating can be done for any duration. Heating time can be from 0.1 minutes to 100 years, or from 1 minute to 24 hours, or from 1 minute to 12 hours, or 30 minutes to 10 hours, or 5 hours, or 6 hours, or 8 hours. During heating the material is kept at a certain temperature. There may be fluctuations in temperature during heating. The fluctuations may be as little as less than 1 or as large as several tens of degrees or more.

(87) Heating can be done using a single heating, a single soaking and a single cooling cycle or it can be done with multiple heating, soaking and cooling cycles. For example, heating can be done to about 250 C., followed by soaking at about 250 C. for some duration, followed by heating to about 300 C., followed by soaking at about 300 C. for some duration, followed by cooling to about 140 C. followed by soaking at about 140 C. for some duration, followed by cooling to about room temperature.

(88) Heating, soaking or cooling steps can be performed for 1 second to several days, more preferably from 30 minutes to several hours. For example, heating can be done to about 250 C. for about 30 minutes, followed by soaking at about 250 C. for about 7 hours, followed by heating to about 300 C. for about 30 minutes, followed by soaking at about 300 C. for about 20 hours or longer, followed by cooling to about 140 C. for about 6 hours, followed by soaking at about 140 C. for about 3 hours, followed by cooling to about room temperature for about 3 hours.

(89) In a preferred embodiment, the polymeric material blended with additive(s) is consolidated, then the consolidated polymeric material is heated in multiple steps to above 200 C., for example heated to 250 C. and soaked at this temperature for at least 4 hours, followed by heating to 300 C. for at least 10 hours but less than 30 hours, followed by cooling to 280 C. and soaking at this temperature for at least an hour, or about 4 hours, or about 7 hours, followed by cooling to room temperature in multiple cooling and soaking steps or one cooling step. The rate at which cooling or heating is done for each step can be different and it can be from 0.0001 C./min to 100 C./min or more, or from 0.1 C./min to about 1 C./min, or about 0.3 C./min, or about 2.5 C./min.

(90) High temperature melting alters the mechanical properties and the wear rate of the polymeric resin. In preferred embodiments the polymeric resin is previously blended with an antioxidant (for example vitamin E, Irganox 1010, or a HALS, or a mixture thereof) and a cross-linking agent (for example a carbon-carbon initiator, Trigonox 311, or P130, or a mixture thereof). During high temperature melting the Izod strength of the material increases while the wear rate of the material decreases as a function of increasing temperature and increasing duration of high temperature melting. In some cases, there are byproducts present from the previous cross-linking and/or generated during high temperature melting. High temperature melting also assists in removal of these byproducts, most of which are volatile. Depending of the formulation of the polymeric resin, that is the additives used, optimization of the high temperature melting parameters would be necessary to avoid too much compromise on the wear rate but at the same time to remove any unwanted byproducts. Not all byproducts are unwanted. In some cases the byproducts are biocompatible, therefore their removal may not be necessary.

(91) After High Temperature Melting

(92) High temperature melting can be done on any size sample of interest. For example, a cylindrical bar with a diameter of approximately less than 1, 1.5, 2, 3, or 4 or larger may be produced by ram extrusion. This bar can be high temperature melted as is or may be machined into smaller samples, implant preforms or implants before or after high temperature melting. Multiple machining steps can be employed in between steps also.

(93) Implant preforms are shapes that are dimensionally larger than implants. After completion of any required processing, the implant preforms are machined by removing anywhere between 100 m to several millimeters or centimeters to obtain the final implant form.

(94) A high temperature melted sample can be exposed to different environments before or after high temperature melting. They can be heated or cooled in water or aqueous solutions, organic solvents, gases or supercritical fluids. They can be under vacuum or partial vacuum or atmospheric conditions. They can be exposed to multiple environmental conditions sequentially for various periods of time.

(95) Extraction of certain molecules, for instance, byproducts of peroxide cross-linking and/or byproducts of high temperature melting and/or residual unreacted peroxide molecules, from samples may be desired before or after high temperature melting. Extraction can be done at any temperature in a desired environment such as in contact with liquids, gases or supercritical fluids.

(96) In an embodiment of the invention, the polymeric resin with one or more additives is consolidated. The consolidated polymeric material is high temperature melted. The high temperature melted polymeric material is machined. High temperature melted, machined polymeric material is placed in an extraction environment for a period of time. The high temperature melted, machined, extracted polymeric material is further machined into implant form. The implant is packaged and sterilized.

(97) In an embodiment of the invention, the polymeric resin with one or more additives is consolidated. The consolidated polymeric material is machined. The machined polymeric material is high temperature melted. Machined, high temperature melted polymeric material is placed in an extraction environment for a period of time. The high temperature melted, machined, extracted polymeric material is further machined into implant form. The implant is packaged and sterilized.

(98) In other embodiments the extraction step is carried out from the consolidated polymeric material.

(99) Extraction defines what is known in the art as removal of some components from polymeric material. Removal can be aided in contact with a solvent, fluid, an emulsion, a slurry, gas or supercritical fluid. Mixtures or stepwise use of different environments can be employed. Extraction can be performed at a temperature from 100 C. to 500 C. or more, more preferably it is performed between room temperature or about 25 C. to about 300 C., more preferably about 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 135, 137, 140, 160, 250, or 300 C. Extraction duration can be 1 minute to several months, more preferably about 24 hours, most preferably about 4 hours. It can be done in partial vacuum, vacuum, ambient conditions or under pressure applied by a liquid, by mechanical means or contained by self-pressurization.

(100) Extraction of unreacted species and/or chemical byproducts is desirable in some implants because they can cause adverse local tissue reactions not well tolerated by the patient. Extraction can be a thermal treatment where the polymeric material (for example peroxide cross-linked antioxidant containing UHMWPE before or after high temperature melting) is subjected to a series of heating to a temperature, soaking at that temperature, and cooling to a temperature. Steps of heat, soak, cool can be used in any order, in any sequence, and/or in as many times as desired or needed. Multiple heat/soak/heat/soak/cool/soak cycles can be used.

(101) High temperature melting of larger size polymeric material is more challenging due to the poor thermal conductivity of the polymeric material. Therefore, the high temperature melting is tailored to ensure that heating and cooling cycles are done in a way to minimize the temperature gradient generated within the polymeric material. However, once one optimizes this process there will always be some thermal gradient, for instance, during heating the surface temperature will stay higher than core temperature and vice versa during cooling. For instance, in one trial we optimized the high temperature melting of a polymeric material of about 4 in diameter and about 10 in length in a nitrogen convection oven by heating the sample first to an elevated temperature close to but below the high temperature melting temperature slowly to obtain uniformity in the sample before heating further to the high temperature melting temperature. In this manner, the temperature non-uniformity during HTM was minimized for a large block sample and the effects of the HTM, which can be dependent on duration were also more uniform. This polymeric material was obtained by ram extruding an approximately 4 diameter bar using GUR 1050 UHMWPE resin powder containing 0.2 wt % Vitamin E and 0.8 wt % P130.

(102) Following high temperature melting, the cooling cycle can also be tailored to minimize the temperature gradient within the polymeric material. The cooling cycle can have cooling to the desired temperatures as well as soaking at desired temperatures. For example the high temperature melting can be carried out, for example at 300 C. for a desired amount of time, for example 30 hours. Subsequently the polymeric material can be cooled down for example to 250 C., for example over a period of a few hours, and soaked at that temperature for a few hours until the temperature within the polymeric material is approximately 250 C. throughout. Subsequently the polymeric material can be cooled down to for example 140 C., for example over a period of a few hours, and soaked at that temperature for a few hours until the temperature within the polymeric material is approximately 140 C. throughout. Subsequently to the polymeric material can be cooled down to 100 C., for example over a period of a few hours or longer, and soaked at that temperature for a few hours until the temperature within the polymeric material is approximately 100 C. throughout. With UHMWPE the crystallization will take place between 140 C. and 100 C. during cool-down; therefore more time may be required to soak the high temperature melted, peroxide cross-linked UHMWPE/vitamin E blend at 100 C. to ensure that the entire polymeric material is crystallized and cooled down to approximately 100 C. Subsequently the polymeric material can be cooled down slowly to room temperature or alternatively additional cool/soak steps can be used.

(103) Consolidation

(104) In one embodiment, a polymeric material is blended with one or more additives, where one or more of these additives are cross-linking agents and one or more of these additives are antioxidants. The blend is then consolidated by ram extrusion. The consolidated blend can then be heated to below or above the melting temperature and/or high temperature melted and cooled. The consolidated and thermally treated polymeric material can be machined into implant preforms or medical implants. The medical implant can be packaged and sterilized.

(105) Some parameters that can be varied during ram extrusion are the ram speed, the feed rate, the barrel diameter, the barrel length, and the barrel temperature. The barrel temperature is typically controlled by multiple heating zones; therefore, one has the flexibility to vary the temperature at some fashion along the length of the ram extrusion barrel. These parameters can be changed to manipulate the properties of the resulting consolidated bar of polymeric material such as mechanical strength, crosslink density, wear rate or toughness among others.

(106) In one embodiment, a polymeric material is blended with one or more additives, where one or more of these additives are cross-linking agents and one or more of these additives are antioxidants. The blend is then consolidated by ram extrusion. The consolidated blended polymeric material can be machined into blocks or implant preforms. The machined blocks or implant preforms can then be heated to below or above the melting temperature and/or high temperature melted and cooled. The consolidated and thermally treated polymeric material can be machined further into medical implants. The medical implant can be packaged and sterilized.

(107) Machining and thermal treatment steps can be repeated as many times as necessary until the final implant is packaged and sterilized. One concern with heat treatment is dimensional stability; if there are a lot of dimensional changes during thermal treatment, then the thermal treatment can be performed on a large consolidated polymeric material such as a bar, a block, or an implant preform. If the dimensional change is less than the machining tolerances for the final implants, then thermal treatment can be performed on a final implant form as well before packaging and sterilization.

(108) Thermal treatment or extraction can be used to remove volatiles from a polymeric material at any stage of processing. For this reason, thermal treatment can be performed with multiple soaking, ramping, heating, cooling steps and utilizing different environments such as inert gas, air or a combination thereof. The thermal treatment can also be performed in other gases, liquids, supercritical fluids or a combination or a sequence thereof.

(109) The cross-linking agent is added to the polymeric material to form a blend and a cross-linking agent can be activated to initiate the cross-linking. Cross-linking agents are chemical additives. Some cross-linking agents can generate free radicals that abstract a hydrogen from the polymeric material to form free radicals on the polymeric material. The free radicals on the polymeric material react with each other to form cross-links. The activation of this type of cross-linking agent, in some embodiments, requires heat. The free radical generation may require decomposition of the cross-linking agent. Therefore the initiation of cross-linking of the polymeric material by such a cross-linking agent would need an activation and/or decomposition of the cross-linking agent. The terms activation and decomposition are used interchangeably to indicate the generation of free radicals to initiate cross-linking of the polymeric material.

(110) Consolidation and cross-linking steps can be performed simultaneously and/or sequentially and can be repeated as many times as needed. Consolidation can have multiple steps of heat, soak, cool repeated in any order or sequence and as many times as needed to achieve acceptable levels of consolidation and crosslinking. In some embodiments the crosslinking agent is thermally activated to initiate the crosslinking process. In these cases if the activation temperature is below or around the temperatures used during consolidation some or all of the crosslinking will take place during consolidation. If the activation temperature is above the consolidation temperature then there will be little or no crosslinking taking place during consolidation. In those cases where little, some, or no crosslinking have occurred during consolidation, the consolidated polymeric material can be heated further to a temperature within a range of temperatures to increase the crosslink density of the polymeric material. For example, if a polymeric material is blended with an organic peroxide whose 1-hour decomposition temperature is 180 C., consolidation for 10-20 minutes at 180 C. will not have substantially decomposed the peroxide and not have led to substantial cross-linking of the polymeric material. In order to increase the cross-link density further, the consolidated, peroxide-blended polymeric material can be heated further to another temperature close to or above 180 C. for one hour or more. This final heating step can be combined with high temperature melting.

(111) Multiple consolidation temperatures can be used during the consolidation cycle. These temperatures, which are often dictated by the temperature of the mold, in which the consolidation is taking place, can be changed in a continuous or step-wise manner. For example, a polymeric material blended with additive(s) can be consolidated starting at around 160 C. for a period of time, then consolidated further at around 190 C. for another period of time. Alternatively, consolidation can start at a temperature of around 140 C. for a period of time, which can be ramped to around 230 C. for a period of time and held there for a period of time over the consolidation period. These temperatures and durations can be changed to increase or decrease the usage of the additive(s) in the polymeric material. For example usage of the additive(s) could be the decomposition of the peroxide additive during consolidation, or the reaction of the antioxidant with the free radicals generated during consolidation, or the reaction of the carbon-carbon initiator additive during consolidation. For example, increasing the temperature may increase the decomposition of an organic peroxide or a carbon-carbon initiator added into the polymeric material and thus may change the rate of cross-linking of the polymeric material. Also, using temperatures for consolidation below the temperatures at which substantial decomposition of the cross-linking agent or peroxide can occur may improve consolidation before cross-linking of the polymeric material. In such cases, the consolidation temperature can be increased to increase the cross-link density after a period at a lower temperature.

(112) In one embodiment, polymeric material blended with one or more additives, some of which may be antioxidant(s) and/or cross-linking agent(s), is consolidated. The consolidated polymeric material is irradiated. The consolidated, irradiated polymeric material is heated to below or above the melting temperature and/or high temperature melted. Then, the irradiated, thermally treated polymeric material is consolidated. The consolidated, irradiated, thermally treated and consolidated polymeric material can be irradiated again. Then, it can be further thermally treated. Finally, the polymeric material can be machined into implants. The implants are packaged and sterilized.

(113) In another embodiment, polymeric material blended with one or more additives, some of which may be antioxidant(s) and/or cross-linking agent(s), is consolidated. The consolidated polymeric material is heated to below or above the melting temperature and/or high temperature melted. Then, the consolidated, thermally treated polymeric material can be irradiated. Finally, the polymeric material can be machined into implants. The implants are packaged and sterilized.

(114) In another embodiment, polymeric material blended with one or more additives some of which may be antioxidant(s) and/or cross-linking agent(s) is consolidated. The consolidated polymeric material is heated to below or above the melting temperature and/or high temperature melted. Then, the consolidated, thermally treated polymeric material can be machined into implants. The implants are packaged and irradiated.

(115) In some embodiments the consolidation is carried out by what is known in the art as ram compression. What is meant by ram compression is the consolidation of polymeric material placed inside a mold where a ram applies the pressure and also where the mold is heated. Typically a ram extrusion set up can be used for this purpose. Instead of a continuous mold with an open end (use with ram extrusion), a mold with a closed end is used. Polymeric material is put inside the mold. Pressure is applied by the ram. The mold is heated. The pressurization and heating can happen in any order. When the consolidation reaches the desired level, the pressure is released and the mold is cooled down. The order in which the pressure is released and the temperature is decreased can vary. The mold can have bleeding valves to remove volatiles that might be formed during consolidation.

(116) Layered Molding Embodiments

(117) In some embodiments, a polymeric material with additive(s) such as cross-linking agent(s) can be consolidated comprising different layers. The layers can include different types of polymeric material or mixtures thereof and/or different concentration of any of the additive(s) incorporated into the polymeric material.

(118) In some embodiments, the consolidation of polymeric material comprising layers can be done such that the resulting consolidated polymeric material is close to the final shape to be used in the final application/product, for example a medical implant. Some minor machining can optionally be performed to result in a final product/implant. In some embodiments the machining is done on all surfaces. In other embodiments the machining is done on selective surfaces: for example only the articular surfaces of a medical implant are machined or only the backside surfaces are machined, and/or one of the articular/backside surfaces is machined together with the peripheral surfaces.

(119) In some embodiments, a polymeric material with additive(s) with no cross-linking agents can be layered into a consolidation mold/chamber together with a second layer comprising a polymeric material with additive(s) at least one of which is a cross-linking agent. In some embodiments the latter layer is placed as the top layer inside the mold or as the bottom layer inside the mold. The two layers are either partially or totally consolidated together or separately by placing in partially or totally in contact with heated surfaces. Partial consolidation can be also done in contact with non-heated surfaces.

(120) In some embodiments, layering can be done in multiple steps of consolidation. Layers can have the same composition or different compositions. Layering can be done with two layers or more layers. Layering can also be used on parts of a surface, for example some areas of the surfaces of the intended final product.

(121) In one preferred embodiment, polymeric material also comprising an antioxidant, for example vitamin E, is placed inside a mold. Subsequently the said polymeric material with an antioxidant is subjected to compression inside the mold to achieve partial consolidation. The said partial consolidation is performed at below room temperature, at room temperature, at above room temperature, or at above the melting point of the said polymeric material. Preferably the said consolidation is performed between room temperature and the melting point of the said polymeric material. Preferably the said consolidation is performed without applying any active heating or cooling to the mold. After the partial consolidation of the said polymeric material, and other polymeric material with an antioxidant and a cross-linking agent is placed on top of the partially consolidated first layer of polymeric material. Subsequently the two layers are consolidated under compression inside the mold. The said consolidation is performed either at a single temperature for a prescribed duration or at different temperatures in different periods of time using a multiple heating, soaking, and cooling cycles in a desired order.

(122) In one preferred embodiment, polymeric material also comprising an antioxidant, for example vitamin E, is placed inside a mold. Subsequently the said polymeric material with an antioxidant is subjected to compression inside the mold to achieve partial consolidation. The said partial consolidation is performed at below room temperature, at room temperature, at above room temperature, or at above the melting point of the said polymeric material. Preferably the said consolidation is performed between room temperature and the melting point of the said polymeric material. Preferably the said consolidation is performed without applying any active heating or cooling to the mold. After the partial consolidation of the said polymeric material, an intermediate heating step(s) can be used such as high temperature melting of the partially consolidated polymeric material. After partial consolidation and heating/cooling, other polymeric material with an antioxidant and a cross-linking agent is placed on top of the partially consolidated first layer of polymeric material. Subsequently the two layers are consolidated under compression inside the mold. The said consolidation is performed either at a single temperature for a prescribed duration or at different temperatures in different periods of time using a multiple heating, soaking, and cooling cycles in a desired order. Such a consolidated polymeric material can be subsequently heated/cooled or machined on one or more surfaces.

(123) Diffusion of Cross-linking Agents

(124) In some embodiments, the polymeric material is blended with additive(s), at least one of which is an antioxidant. Then the antioxidant-blended polymeric material can be machined into an implant or implant preform. Cross-linking agent(s) are diffused into the implant or implant preform. The depth of diffusion can be varied depending on the diffusion parameters. Cross-linking agent can be activated such that a cross-linked implant or implant preform is obtained. At least one cross-linking agent can be a peroxide. In the case of peroxides, cross-linking can be (further) activated by heating the implant preform or implant to close to or above the decomposition temperature(s) of the peroxide(s). In some embodiments the temperature of diffusion will be high enough to decompose the peroxide as it diffuses in to the implant or implant preform or the polymeric material, thereby cross-linking the polymeric material during diffusion. Then, the polymeric material can be machined into an implant. The implant can be packaged and sterilized. In some embodiments the diffusion will be performed using a machined implant, therefore no further machining may be necessary.

(125) Diffusion of the cross-linking agent can be done in its pure form, in solution or in emulsion. That is, the antioxidant-blended polymeric material can be contacted with the cross-linking agent formulation in the form of gas, liquid, solid, melt, slurry, emulsion, supercritical fluid or a mixture or sequence thereof. For example, an organic peroxide can be emulsified using an emulsifier (a chemical additive which can aid in the more uniform distribution/dispersion of compound(s) in liquids where it is not dissolved well, for example Tween 20) in water or an aqueous based solution. The antioxidant-blended polymeric material can be contacted with this emulsion for a desired period of time to allow the diffusion of the cross-linking agent into the polymeric material. Diffusion can be done below room temperature, around room temperature, at an elevated temperature below or above the melting point of the polymer. The diffusion medium can contain other additives in addition to the cross-linking agent and the emulsifier. For example, the diffusion medium can contain other antioxidant(s), cross-linking agent(s) or any other desired molecule that can diffuse into the polymeric material.

(126) Diffusion of additive(s) into the polymeric material can be done for 1 minute to several weeks, preferably from 1 hour to 24 hours, more preferably from 1 hour to 12 hours, most preferably from 1 hour to 8 hours.

(127) Cross-linking can take place during diffusion depending on the diffusion medium, temperature and duration. Alternatively or in addition, the additive-diffused polymeric material can be heated further after the diffusion step. If the samples were heated during diffusion, then they can be cooled before this heating step. Heating can be done to a temperature between room temperature and 500 C., preferably to between room temperature and 250 C., or to 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370 or 380 C. As in other embodiments in this application, heating can be done in a gaseous environment, liquid environment, in contact with solids or in a supercritical environment or a combination or a sequence thereof. Heating can be done for 1 minute to several weeks, preferably from 1 hour to 24 hours, more preferably from 1 hour to 12 hours, most preferably from 1 hour to 8 hours. If the heating is performed with the purpose of decomposing an organic peroxide used as a cross-linking agent for the polymeric material, then the heating temperature can be close to or above the 1-hour decomposition temperature of the peroxide.

(128) In one preferred embodiment, polymeric material also comprising an antioxidant, for example vitamin E, is placed inside a mold. Subsequently the said polymeric material with an antioxidant is subjected to compression inside the mold to achieve partial consolidation. The said partial consolidation is performed at below room temperature, at room temperature, at above room temperature, or at above the melting point of the said polymeric material. Preferably the said consolidation is performed between room temperature and the melting point of the said polymeric material. Preferably the said consolidation is performed without applying any active heating or cooling to the mold. After the partial consolidation of the said polymeric material, an intermediate heating step(s) can be used such as high temperature melting of the partially consolidated polymeric material. After partial consolidation and heating/cooling, additive(s) including antioxidant(s) and/or cross-linking agent(s) can be diffused into the polymeric material. Subsequently the partially consolidated, heated/cooled, additive-diffused polymeric material is consolidated under compression inside a mold. The said consolidation is performed either at a single temperature for a prescribed duration or at different temperatures in different periods of time using a multiple heating, soaking, and cooling cycles in a desired order. Such a consolidated polymeric material can be subsequently heated/cooled or machined on one or more surfaces.

(129) In some embodiments the efficiency of the peroxide initiated cross-linking can be increased by the addition of co-agents, also known as cross-linking activators such as triallyl cyanurate, triallyl isocyanurate, quinone dioxime, diallyl phthalate, ethylene glycol dimethacrylate, trimethylolpropane trimethacrylate, N,N-m-phneylenebismaleimide, 1,2-poly-butadiene and so on.

(130) In other embodiments the extent of scorch can be reduced. By scorch is meant premature cross-linking before consolidation of polymeric material during heating and pressurizing for the cross-linking and consolidation step. It is desirable to consolidate the polymeric material before cross-linking; therefore it is desirable to reduce the extent of scorch. In some cases if cross-linking of the polymeric material occurs before consolidation reaches the desirable level, it may become more difficult for consolidation to be taken to the desirable level. The scorch can be reduced or inhibited by using anti-scorch compounds such as nitrites, 2-mercaptobenzothiazole, and/or hydroquinones. For example 2,4-diphenyl-4-methyl-1-pentene (-methylstyrene dimer), 1,1-diphenylethylene (substituted or unsubstituted), [1,3,5-tris(4-tert-butyl-3-hydroxy-2,6-dimethylbenzyl)-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione], 4,4-thiobis(2-methyl-6-t-butylphenol), 2,2-thiobis(6-t-butyl-4-methyphenol), or mixtures thereof can be used as scorch inhibitor(s). The scorch inhibitor can be added at any concentration into the polymeric material.

(131) In some of the embodiments individual antioxidants or mixtures are used as anti-scorching agents. For example, a primary antioxidant is used together with other secondary antioxidants as anti-scorching agents. Commercial Irganoxes, for instance Irganox 300 (4,40-Thiobis(6-tertbutyl-3-methylphenol), Irganox 1010 (Tetra[methylene -b-(3,5-ditertbutyl-4-hydroxyphenyl)-propionate] methane), Irganox 1035 (3,5-Bis(1,1-dimethylethyl)-4-hydroxyhydroxybenzenepropanoic acid thiodi-2,1-ethanediyl ester), Irganox 1076 (n-Octadecyl-b-(4-hydroxy-3,5-ditertbutylphenyl) propionate), or other hindered phenol type antioxidants, Vitamin E, vitamin acetate, can be used as primary antioxidants. These antioxidants can be used together with secondary antioxidants such as commercial Irganoxes, Irganox 168 (Tris(2,4-ditertbutyl) phosphate), Irganox 242 (2,4-Ditertbutylphenyl phosphate) and Irganox(DLTP dilaurylthiodipropionate(didodecyl-3,3-thiodipropinate)). The anti-scorching agents can be used together with peroxide cross-linking agents during consolidation. Subsequently, the consolidated polymeric material containing cross-linking agents and anti-scorching agents can be subjected to high temperature melting and subsequently machined into implants, packaged, and sterilized.

EXAMPLES

Example 1

The Increased Occurrence of Defects with Increasing Temperature

(132) GUR1020 UHMWPE compression molded barstock (60 mm by 60 mm cross-section; Orthoplastics, UK) was cut in approximately 100 mm-long pieces. The pieces (n=5 each) were high temperature melted at different temperatures ranging from 305 C. to 320 C. for 6 to 12 hours (Table 2). After cooling down to room temperature, the samples were cut in half and the crossection was investigated for defects. The incidence of defects was noted.

(133) TABLE-US-00002 TABLE 2 The probability of observing a defect in completely consolidated, then high temperature melted UHMWPEs. All were GUR1020 UHMWPE HTM Type of Temperature % UHMWPE and Time Vinyl Index defect Virgin 305 C.-12 hrs 0.063 20 Virgin 305 C.-8 hrs 0.049 20 Virgin 310 C.-8 hrs 0.048 (w/o defects) 20 0.068 (w/defects) Virgin 310 C.-12 hrs 0.068 20 0.1 wt % vitamin 310 C.-6 hrs 0.021 <20 E blend Virgin 315 C.-6 hrs 0.067 80 0.1 wt % vitamin 320 C.-6 hrs 0.060 40 E blend

(134) Thin sections (150 m) were microtomed across the cross-section and Fourier transform infrared spectroscopy was used to obtain spectra. Several data points were taken along the depth of the sample at 4 cm.sup.1 and average of 32 scans was recorded. A vinyl index was calculated using the area under 880-920 cm.sup.1 and normalizing it to the area under 1895 cm.sup.1 (1850-1985 cm.sup.1).

(135) Increasing the temperature and increasing the time of exposure during high temperature melting have been associated with increased vinyl index and increased elongation (Fu et al. Polymer 51: 2721-2731 (2010)).

(136) It was observed that the probability of observing a defect generally increased with increasing temperature (Table 1) and increasing vinyl index (FIG. 4).

Example 2

The Effect of the Pre-molding Step on Defects

(137) A GUR1020 UHMWPE resin powder (200 g) was poured into a cylindrical mold with about 67 mm diameter and compressed with 4000 lbs (5 MPa) between platens pre-heated to 181 C., for 20 minutes, then was cooled down to about room temperature. The pre-molded or partially consolidated green pellet was taken out of the mold and placed in a convection oven pre-heated to 320 C. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for 6 hours and cooling after this period to about room temperature. The pre-molded and high temperature melted puck was placed into the same mold used for pre-molding and compressed with 41200 lbs (50 MPa) between platens pre-heated to 194 C., for 15 minutes, then was cooled down to about room temperature before releasing the pressure. This cylindrical puck was cut horizontally roughly in the middle (as shown in FIG. 1b) and no defects were noted (FIG. 5).

Example 3

The Mechanical Properties of Partially Consolidated, High Temperature Melted and Completely Molded UHMWPE Via the Two-step Molding

(138) GUR1020 UHMWPE resin powder was poured into a cylindrical mold with about 100 mm diameter and compressed with 4000 lbs (2 MPa) between platens pre-heated to 358 F(181 C.) for 10 minutes, then was cooled down to about room temperature. The partially consolidated pellet was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. One sample was processed at 280 C. for 6 hours, one sample was processed at 300 C. for 5 hours, one sample was processed at 310 C. for 6 hours and one sample was processed at 320 C. for 6 hours. After HTM, the cylindrical pucks were placed back into the consolidation mold and molded completely between platens pre-heated to 381 F (194 C.) for 10 minutes at 20 MPa, then was cooled down to about room temperature under pressure.

(139) Tensile testing was performed on dog-bones (Type V, ASTM D-638) stamped out of 3.2 mm-thick sections machined from the final pucks. Testing was performed at 10 mm/min (MTS Insight, Eden Prairie, Minn.). Elongation to break (EAB) was determined by using a laser extensometer. Ultimate tensile strength (UTS) and yield strength (YS) were also measured.

(140) IZOD impact testing was performed on impact coupons (63.5 mm12.7 mm6.35 mm) after double notching according to ASTM F648.

(141) There were no defects observed in these samples. The ultimate tensile strength and the yield strength were high and the elongation at break was exceptionally high, especially for the sample processed at 320 C. (Table 3).

(142) TABLE-US-00003 TABLE 3 Tensile mechanical properties of partially consolidated, high temperature melted and completely consolidated UHMWPE via the two-step molding process. GUR 1020 resin was used. UTS: Ultimate tensile strength; EAB: elongation at break; YS: yield strength; VI: vinyl index; HTM: high temperature melting IZOD HTM Impact Temperature Strength UTS EAB YS and time (kJ/m.sup.2) (MPa) % (MPa) VI 280 C.-6 h 153 3.6 49.6 1.7 434 15 21.5 0.3 0.02 0.01 300 C.-5 h 112 5.8 45.2 1.3 492 23 22.1 0.7 0.04 0.00 310 C.-6 h 92.1 1.3 49.9 0.2 702 10 23.4 0.2 0.07 0.01 320 C.-6 h 69.1 1.4 48.3 1.1 975 43 24.3 0.6 0.10 0.01

Example 4

The Properties of Partially Consolidated, High Temperature Melted and Completely Molded UHMWPE Via the Two-step Molding Followed by Radiation Cross-linking

(143) GUR1020 UHMWPE resin powder was blended with 2 wt % vitamin E by solvent blending and dried. Further the blend was diluted to 0.2 wt % vitamin E by mixing with virgin GUR1020 powder. The 0.2 wt % vitamin E-blended powder was poured into a cylindrical mold with about 100 mm diameter and compressed with 4000 lbs (2 MPa) between platens pre-heated to 358 F(181 C.) for 10 minutes, then was cooled down to about room temperature. The pre-molded polymeric material was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. Samples were processed at 320 C. for 6 hours. After HTM, the cylindrical pucks were placed back into the consolidation mold and molded completely between platens pre-heated to 381 F (194 C.) for 10 minutes at 20 MPa, then was cooled down to about room temperature under pressure. Then the pucks were irradiated using electron beam irradiation to 150 kGy, 175 kGy and 200 kGy (n=4 each). After radiation cross-linking, 2 pucks of each radiation dose were annealed in nitrogen at 130 C. for 5 hours.

(144) Tensile testing was performed on dog-bones (Type V, ASTM D-638) stamped out of 3.2 mm-thick sections machined from the final pucks. Testing was performed at 10 mm/min (MTS Insight, Eden Prairie, Minn.). Elongation to break (EAB) was determined by using a laser extensometer. Ultimate tensile strength (UTS) and yield strength (YS) were also measured.

(145) IZOD impact testing was performed on impact coupons (63.5 mm12.7 mm6.35 mm) after double notching according to ASTM F648.

(146) Wear testing was done on a custom-designed bidirectional pin-on-disc (POD) tester in undiluted bovine serum. Cylindrical pins (9 mm diameter, 13 mm length) were tested at 2 Hz under a peak load of 440 lbs for 1.2 million cycles (MC). They were weighed and the wear was determined gravimetrically at 500,000 cycles and every 157,000 cycles after that. Wear rate was determined by a linear regression of weight loss as a number of cycles from 500,000 cycles to 1.2 million cycles.

(147) The mechanical properties of these samples are shown in Table 4 and the wear rates are shown in Table 5. The mechanical properties of the partially consolidated puck were as follows: UTS 7.80.2 MPa; YS 1.30.2 MPa and EAB 8.20.9%.

(148) TABLE-US-00004 TABLE 4 Tensile mechanical properties of partially consolidated, high temperature melted and completely consolidated 0.2 wt % vitamin E-blended UHMWPE via the two-step molding process followed by irradiation. GUR 1020 resin was used. UTS: Ultimate tensile strength; EAB: elongation at break; YS: yield strength; VI: vinyl index; HTM: high temperature melting IZOD Impact UTS EAB YS Radiation Dose Strength (kJ/m.sup.2) (MPa) % (MPa) 150 kGy 77 1.5 39 2 411 13 26 0.3 175 kGy 73 0.3 38 1 383 9 25 0.1 200 kGy 71 1.3 40 2 306 14 26 0.5 150 kGy annealed 75 1.7 43 1 451 13 25 0.2 175 kGy annealed 67 1.1 39 2 377 7 25 0.7 200 kGy annealed 62 0.5 38 2 339 18 24 0.2

(149) Also, thin sections (150 m) were microtomed across the cross-section of the pre-molded, high temperature melted and completely consolidated puck and Fourier transform infrared spectroscopy was used to obtain spectra. Several data points were taken along the depth of the sample at 4 cm.sup.1 and average of 32 scans was recorded. A vinyl index was calculated using the area under 880-920 cm.sup.1 and normalizing it to the area under 1895 cm.sup.1 (1850-1985 cm.sup.1). The vinyl index of the said puck before irradiation was 0.09.

Example 5

Comparison of the Properties of Samples Made Using One-step and Two-step Molding Processes with High Temperature Melting (HTM)

(150) GUR1020 UHMWPE resin powder was blended with 2 wt % vitamin E by solvent blending and dried. Further the blend was diluted to 0.2 wt % vitamin E by mixing with virgin GUR1020 powder.

(151) For the two-step molding process, the 0.2 wt % vitamin E-blended powder (100 g) was poured into a cylindrical mold with about 100 mm diameter and compressed with 4000 lbs (2 MPa) between platens pre-heated to 358 F(181 C.) for 10 minutes, then was cooled down to about room temperature. The pre-molded polymeric material was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. Samples were processed at 300 or 310 C. for 6 hours. After HTM, the cylindrical pucks were placed back into the consolidation mold and molded completely between platens pre-heated to 381 F (194 C.) for 10 minutes at 20 MPa, then was cooled down to about room temperature under pressure.

(152) For the one-step process, the 0.2 wt % vitamin E-blended powder (100 g) was poured into a cylindrical mold with about 100 mm diameter and compressed at 20 MPa between platens pre-heated to 381 F (194 C.) for 10 minutes, then was cooled down to about room temperature. The consolidated polymeric material was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. Samples were processed at 280, 300, 310 or 320 C. for 6 hours.

(153) The mechanical properties and vinyl index (VI) of the samples are shown in Table 5. Both sets of samples had good properties for consolidated UHMWPE material for use in joint implants.

(154) TABLE-US-00005 TABLE 5 Wear rate of partially consolidated, high temperature melted and completely consolidated 0.2 wt % vitamin E-blended UHMWPE via the two-step molding process followed by irradiation. GUR 1020 resin was used. (mg/MC; milligram/million cycle) Radiation Dose Wear rate (mg/MC) No irradiation 14.3 0.6 150 kGy 1.6 0.9 175 kGy 1.4 0.2 200 kGy 0.9 0.1 150 kGy annealed 1.3 0.2 175 kGy annealed 0.7 0.1 200 kGy annealed 0.6 0.1

(155) TABLE-US-00006 TABLE 5 Comparison of the two-step HTM process with the one-step HTM process IZOD Impact Strength UTS EAB YS Sample (kJ/m.sup.2) (MPa) % (MPa) VI Partial molding + HTM + Secondary Molding HTM @ 280 C.- 153 3.6 50 1.7 434 15 21.5 0.3 0.02 0.01 6 h HTM @ 300 C.- 112 5.9 49 6.8 543 52 22.5 0.2 0.03 0.00 6 h HTM @ 310 C.- 92.1 1.3 50 0.2 702 10 23.4 0.2 0.07 0.01 6 h HTM @ 320 C.- 69.1 1.4 48 1.1 975 43 24.3 0.6 0.10 0.01 6 h Molding + HTM HTM @ 300 C.- 94.9 1.0 50 4.9 632 25 22.9 0.2 0.05 0.00 6 h HTM @ 310 C.- 62.3 2.5 49 2.0 832 61 24.0 0.5 6 h

Example 6

Comparison of the Properties of Samples Made Using One-step and Two-step Molding Processes with High Temperature Melting (HTM) Followed by Irradiation

(156) GUR1020 UHMWPE resin powder was blended with 2 wt % vitamin E by solvent blending and dried. Further the blend was diluted to 0.2 wt % vitamin E by mixing with virgin GUR1020 powder.

(157) For the two-step molding process, the 0.2 wt % vitamin E-blended powder (100 g) was poured into a cylindrical mold with about 100 mm diameter and compressed with 4000 lbs (2 MPa) between platens pre-heated to 358 F(181 C.) for 10 minutes, then was cooled down to about room temperature. The pre-molded polymeric material was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. Samples were processed at 320 C. for 6 hours. After HTM, the cylindrical pucks were placed back into the consolidation mold and molded completely between platens pre-heated to 381 F (194 C.) for 10 minutes at 20 MPa, then was cooled down to about room temperature under pressure.

(158) For the one-step process, the 0.2 wt % vitamin E-blended powder (100 g) was poured into a cylindrical mold with about 100 mm diameter and compressed at 20 MPa between platens pre-heated to 381 F (194 C.) for 10 minutes, then was cooled down to about room temperature. The consolidated polymeric material was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. Samples were processed at 320 C. for 6 hours.

(159) Both sets of samples were irradiated to 175 kGy at 25 kGy/pass using electron beam irradiation on a 10 MeV beam line. Some samples of each set were further annealed at 130 C. in nitrogen for 5 hours.

(160) The mechanical properties and wear rate of these samples are shown in Table 6. Both sets of samples had good properties for consolidated UHMWPE material for use in joint implants.

(161) TABLE-US-00007 TABLE 6 Comparison of radiation cross-linked, 0.2 wt % vitamin E-blended HTM UHMWPE with the one-step or two-step HTM process. The two-step HTM process involved HTM at 320 for 6 hours followed by complete molding and 175 kGy irradiation. The one-step HTM process involved HTM at 310 for 8 hours followed by 175 kGy irradiation IZOD Impact Strength Wear rate Sample (kJ/m.sup.2) UTS (MPa) EAB % YS (MPa) (mg/MC) One-Step 75.4 1.4 42.9 0.8 341 12 23.2 0.8 1.1 0.2 Two-Step 72.8 0.3 37.5 0.5 383 9 25.3 0.1 1.4 0.2 One-Step 71.2 1.3 45.0 0.9 359 2 21.7 0.9 0.8 0.1 annealed Two-Step 66.7 1.1 38.7 1.7 377 7 24.7 0.7 0.7 0.1 annealed

Example 7

Layered Molding of Pre-molded, High Temperature Melted UHMWPE and UHMWPE Resin Powder with Cross-linking Agents

(162) GUR1020 UHMWPE resin powder was blended with 2 wt % vitamin E by solvent blending and dried. Further the blend was diluted to 0.2 wt % vitamin E by mixing with virgin GUR1020 powder.

(163) The 0.2 wt % vitamin E-blended powder (100 g) was poured into a cylindrical mold with about 100 mm diameter and compressed with 4000 lbs (2 MPa) between platens pre-heated to 358 F(181 C.) for 10 minutes, then was cooled down to about room temperature. The pre-molded polymeric material was taken out of the mold and placed in a convection oven pre-heated to temperature. The oven was purged with nitrogen and the nitrogen flow was maintained during heating and maintaining the sample at temperature for the desired amount of time and cooling after this period to about room temperature. Samples were processed at 320 C. for 6 hours.

(164) GUR1050 UHMWPE resin powder was blended with 2 wt % vitamin E by solvent blending and dried. Further the blend was diluted to 0.8 wt % vitamin E by mixing with virgin GUR1050 powder. The vitamin E-blended UHMWPE was blended further with 1 wt % 2,5-Di(tert-butylperoxy)-2,5-dimethyl-3-hexyne (P130).

(165) After HTM, the pre-molded GUR1020 UHMWPE placed back into the consolidation mold and layered with the vitamin E and P130-blended GUR1050 UHMWPE and molded completely between platens pre-heated to 381 F (194 C.) for 10 minutes at 20 MPa, then was cooled down to about room temperature under pressure.

(166) IZOD impact testing was performed on impact coupons (63.5 mm12.7 mm6.35 mm) after double notching according to ASTM F648.

(167) Wear testing was done on a custom-designed bidirectional pin-on-disc (POD) tester in undiluted bovine serum. Cylindrical pins (9 mm diameter, 13 mm length) were tested at 2 Hz under a peak load of 440 lbs for 1.2 million cycles (MC). They were weighed and the wear was determined gravimetrically at 500,000 cycles and every 157,000 cycles after that. Wear rate was determined by a linear regression of weight loss as a number of cycles from 500,000 cycles to 1.2 million cycles.

(168) The impact strength and the surface wear rate of this layered molded UHMWPE are shown in Table 7.

(169) TABLE-US-00008 TABLE 7 The properties of layered molded pre-molded, high temperature melted UHMWPE and cross-link agent-blended UHMWPE powder Impact Strength POD Wear Sample (kJ/m.sup.2) Rate (mg/MC) Bulk: 0.8 wt % VE (1020) Pellet + 125.61 2.75 3.13 0.43 HTM @ 300 C.-5 h + Surface Layer: 0.8 wt % VE (1050)/1 wt % P130

Example 8

Formation of a Tibial Insert

(170) FIGS. 6 and 7 show the formation of a tibial insert with highly cross-linked articular surface with good wear resistance and HTM treated bulk with good mechanical properties. The HTM treated bulk layer is prepared by molding a green polyethylene containing vitamin E followed by high temperature melting. Optionally, this bulk layer is either fully consolidated first and then used in the molding steps described here, or it is used as-is after the HTM step in the molding steps described here.

(171) The two layers are placed inside a mold and molded together at elevated temperature and pressure. The pressure is applied by the plunger. In some embodiments, it is desirable to have three layers inside the mold. For example first a peroxide and antioxidant containing polyethylene blend at the bottom, then in the middle an HTM processed layer, and finally at the top another peroxide and antioxidant containing polyethylene blend (FIG. 6). In a second example, first a peroxide and antioxidant containing polyethylene blend powder at the bottom, then in the middle an HTM processed layer, and finally at the top another layer of peroxide and antioxidant containing polyethylene blend powder (FIG. 7).

Example 9

Blending of Polymeric Material with Antioxidant(s)

(172) Medical grade GUR1020 and GUR1050 UHMWPEs (Celanese, Texas, USA) were blended with 0.8 wt % vitamin E by first preparing a master batch containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA). Vitamin E was dissolved in IPA at room temperature and the solution was mixed with the medical grade UHMWPE (either with GUR 1020 or GUR 1050). The IPA was then evaporated to obtain master batches of vitamin E/UHMWPE blends either with GUR 1020 or GUR 1050. Then, the two master batches (also called master blends of vitamin E/UHMWPE here) were separately diluted to the desired vitamin E concentration by mixing with virgin (by virgin is meant UHMWPE with no antioxidant or cross-linking agent added) GUR 1020 or GUR 1050.

Example 10

Blending of Antioxidant-blended UHMWPE with Cross-linking Agent

(173) An approximately 100 g batch of 0.8 wt % vitamin E-blended UHMWPE was prepared by mixing either of the 2 wt % master batches with the virgin corresponding UHMWPE resin (i.e. GUR 1020 or GUR 1050). These were then individually mixed with pure peroxide (2,5-dimethyl-2,5-Di-(tbutylperoxy)hexyne-3, also called Luperox 130, peroxide 130 or DYBP or P130) in the concentrations of 0.5, 1.0 or 1.5 wt % peroxide.

Example 11

Oxidation Induction Time (OIT) Testing

(174) The oxidation induction time (OIT) was determined using a differential scanning calorimeter (DSC) (Discovery, TA Instruments, Newark, Del., USA), which was calibrated by indium as the standard. The test was performed in accordance with an ISO standard (ISO11357-6: 2002). Small samples (5 mg, n=3 each) were placed in an uncovered T.sub.0 pan (an open DSC pan) and heated from 20 to 200 C. at a rate of 20 C./min under a nitrogen flow of 50 ml/min. After maintaining nitrogen flow for 5 minutes at 200 C. to attain thermal equilibrium, the gas was then switched from nitrogen to oxygen at a flow rate of 50 ml/min (marked as the start point of experiment). The onset of oxidation (exothermic reaction) was recorded as the OIT in minutes, and was determined as the intercept of the extended baseline and the steepest tangent drawn to the exotherm.

Example 12

Cross-link Density Measurements

(175) The cross-link density was measured using small sections (approximately 333 mm, n=3 each) prepared manually by cutting with a razor blade. The samples were placed in 25 mL of pre-heated xylene at 130 C. in an oil bath and were allowed to swell for 2 hours. The dry sample weight and the swollen sample weight were measured in sealed containers before and after xylene immersion to determine a gravimetric swell ratio. The gravimetric swelling ratio was converted to a volumetric swelling ratio using the density of the dry polymer as 0.94 g/cm.sup.3 and the density of xylene at 130 C. as 0.75 g/cm.sup.3. The cross-link density of the samples (n=3 each) was calculated using the following equations:

(176) $\begin{array}{cc}{d}_x=\frac{\ln \left(1-q_{\mathrm{eq}}^{-1}\right)+q_{\mathrm{eq}}^{-1}+{\mathrm{Xq}}_{\mathrm{eq}}^{-2}}{V_1\left(q_{\mathrm{eq}}^{-1/3}-q_{\mathrm{eq}}^{-2}\right)}& \left(\mathrm{Eq}.1\right)\\ X=0.33+\frac{0.55}{q_{\mathrm{eq}}}& \left(\mathrm{Eq}.2\right)\end{array}$
where the specific volume of xylene, V.sub.1, was 136 cm.sup.3/mol.

Example 13

Bidirectional Pin-on-Disc (POD) Wear Testing

(177) Wear testing was done on a custom-designed bidirectional pin-on-disc (POD) tester in undiluted bovine serum. Cylindrical pins (9 mm diameter, 13 mm length) were tested using a 510 mm rectangular pattern of articulation at 2 Hz under a peak load of 440 lbs for 1.2 million cycles (MC). They were weighed and the wear was determined gravimetrically at daily intervals. Wear rate was determined by a linear regression of weight loss as a function of number of cycles. The wear rate was reported in milligrams/million cycle (mg/MC).

Example 14

Tensile Mechanical Testing

(178) Tensile testing was performed on dog-bones (Type V, ASTM D-638) stamped out of 3.2 mm-thick sections machined from the prepared pucks. Testing was performed at a grip displacement speed of 10 mm/min (MTS Insight, Eden Prairie, Minn.). Elongation to break (EAB) was determined by using a laser extensometer. Ultimate tensile strength (UTS) and yield strength (YS) were also measured.

Example 15

IZOD Impact Testing

(179) IZOD impact testing was performed on impact coupons (63.5 mm12.7 mm6.35 mm) after double notching according to ASTM F648.

Example 16

The Effect of High Temperature Melting on 0.8 wt % Vitamin E-blended, Peroxide Cross-linked UHMWPEs

(180) An approximately 100 g batch of 0.8 wt % vitamin E-blended UHMWPE was prepared by mixing either of the 2 wt % master batches described above with the virgin corresponding UHMWPE resins (i.e. GUR 1020 or GUR 1050). These were then individually mixed with pure peroxide (2,5-dimethyl-2,5-Di-(tbutylperoxy)hexyne-3, also called Luperox 130, peroxide 130 or DYBP or P130) in the concentrations of 0.5, 1.0 or 1.5 wt % peroxide.

(181) The vitamin E and peroxide-blended UHMWPE batches were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below their melting point, resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(182) The resulting pucks were either tested as is or further treated by high temperature melting at 300, 310 or 320 C. for 5 hours and then cooling in nitrogen in a convection oven.

(183) Samples were tested for oxidation induction time (OIT), cross-link density, POD wear rates, tensile mechanical properties and IZOD impact strength as described above in Examples 11, 12, 13, 14 and 15.

(184) TABLE-US-00009 TABLE 8-1 The physicochemical and tensile mechanical properties of 0.8 wt % vitamin E-blended and 1 wt % peroxide-blended UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensilestrength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) GUR 1050 group No HTM 27.3 259 5 2.2 0.0 41.0 3.0 309 14 77.1 0.5 HTM @ 300 C.-5 h Not- 169 7 1.7 0.1 36.6 7.1 338 31 94.2 0.7 tested HTM @ 310 C.-5 h 45.6 2.0 124 2 Not- 42.4 6.0 388 5 Not- tested tested HTM @ 320 C.-5 h 42.8 2.0 157 6 2.2 0.0 42.6 2.3 454 9 108 1.3 GUR 1020 group No HTM Not- 206 4 Not- 41.0 2.0 292 5 80.4 0.8 tested tested HTM @ 310 C.-5 h 46.8 2.3 114 21 Not- 43.2 4.2 422 17 Not- tested tested

(185) The UHMWPE blends cross-linked during compression molding. The subsequent HTM decreased cross-link density regardless of the HTM temperature used. After HTM, oxidation induction time was increased. Wear rate and UTS were not significantly changed after HTM. EAB and IZOD impact strength were significantly increased after HTM; suggesting increased ductility and toughness.

(186) Typically the wear rate of uncrosslinked UHMWPE would be around 8-10 mg/mc. Peroxide crosslinking achieved during compression was able to reduce the wear rate.

Example 17

The Effect of High Temperature Melting on 0.5 wt % Vitamin E-blended, Peroxide Cross-linked UHMWPEs

(187) Approximately 100 g batch of 0.5 wt % vitamin E-blended UHMWPE was prepared by mixing the 2 wt % vitamin E/GUR 1050 UHMWPE master batch of Example 9 with the virgin GUR 1050 UHMWPE, which was then mixed with pure P130 in the amount of 0.9 wt % peroxide.

(188) The vitamin E and peroxide-blended UHMWPE batch was compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(189) The resulting pucks were either tested as is or further treated by high temperature melting at 300, 310 or 320 C. for 5 hours and then cooling in nitrogen in a convection oven.

(190) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Examples 11, 12, 13, 14 and 15.

(191) TABLE-US-00010 TABLE 9-1 The physicochemical and tensile mechanical properties of 0.5 wt % vitamin E-blended and 0.9 wt % peroxide-blended UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) No HTM 20.9 0.4 252 10 1.3 0.2 36.9 3.7 291 15 77.2 0.6 HTM @ 300 C.- 5 h 31.5 2.1 166 4 1.4 0.2 36.2 4.4 399 36 92.7 1.1 HTM @ 310 C.- 5 h 27.1 5.1 124 3 1.4 0.2 39.3 2.2 420 9 99.7 0.7 HTM @ 320 C.- 5 h 36.5 1.4 78 1 2.2 1.2 35.2 6.5 411 39 101 3.3

(192) The UHMWPE blends cross-linked during compression molding. The subsequent HTM decreased cross-link density at all temperatures. After HTM, oxidation induction time was increased. UTS was not affected substantially. Wear rate was increased only after melting at 320 C. EAB and IZOD impact strength were significantly increased at all HTM temperatures; suggesting increased ductility and toughness.

Example 18

The Effect of Peroxide Concentration on the Properties after HTM of 0.5 wt % vitamin E-blended GUR1050 and GUR 1020 UHMWPEs

(193) An approximately 100 g batch of 0.5 wt % vitamin E-blended GUR 1050 UHMWPE was prepared by mixing the 2 wt % vitamin E/GUR 1050 UHMWPE master batch of Example 9 with the virgin GUR 1050 UHMWPE, which was then mixed with P130 in the amounts of 0.7, 0.9 or 1.1 wt % peroxide. Similarly, a 100 g batch of the 0.5 wt % vitamin E-blended GUR 1020 UHMWPE was mixed with P130 in the amounts of 0.9, 1.0 or 1.1 wt % peroxide.

(194) The vitamin E and peroxide-blended UHMWPE blends were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(195) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven.

(196) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(197) TABLE-US-00011 TABLE 10-1 The physicochemical and tensile mechanical properties of 0.5 wt % vitamin E-blended peroxide-blended GUR 1050 UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.7 wt % peroxide No HTM 19.5 1.6 235 6 2.3 0.3 40.8 5.2 331 12 79.8 0.4 HTM @ 310 C. 24.2 3.6 88 1 4.5 2.0 45.2 1.8 416 20 112 1.3 0.9 wt % peroxide No HTM 20.9 0.4 252 10 1.3 0.2 36.9 3.7 291 15 77.2 0.6 HTM @ 310 C. 27.1 5.1 124 3 1.4 0.2 39.3 2.2 420 9 99.7 0.7 1.1 wt % peroxide No HTM 20.3 256 12 1.2 0.2 36.7 2.4 224 74 69.5 0.4 HTM @ 310 C. 23.8 165 7 0.7 0.1 31.6 1.9 353 14 88.2 0.7

(198) For 0.5 wt % vitamin E-blended and peroxide-crosslinked GUR1050 UHMWPE (Table 10-1), high temperature melting increased OIT, EAB and impact strength and decreased cross-link density for all peroxide concentrations. The wear rate increased for the lowest concentration of peroxide. The wear rate did not change for 0.9 wt % peroxide and decreased for 1.1 wt % peroxide.

(199) For 0.5 wt % vitamin E-blended and peroxide-crosslinked, high temperature melted GUR1020 UHMWPE (Table 10-2), increasing peroxide concentration decreased wear rate, EAB and impact strength but did not significantly change the other measured properties. Compared to 0.5 wt % vitamin E-blended, peroxide cross-linked UHMWPE using the same peroxide concentration (0.9 and 1.1 wt %; Table 10-1), OIT and wear rate were higher, impact strength was lower and there were no significant changes in the other measured properties.

(200) TABLE-US-00012 TABLE 10-2 The physicochemical and tensile mechanical properties of 0.5 wt % vitamin E-blended peroxide-blended GUR 1020 UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.9 wt % peroxide HTM @ 310 C. 39.4 2.9 124 5 2.3 1.2 44.1 3.1 428 12 99.0 0.1 1.0 wt % peroxide HTM @ 310 C. 38.5 1.4 135 5 0.9 0.1 41.1 1.9 412 8 94.4 0.4 1.1 wt % peroxide HTM @ 310 C. 37.9 2.2 137 1 Not- 43.2 1.8 374 7 90.3 0.6 tested

Example 19

The Use of Other Antioxidants in Peroxide Cross-linked and/or High Temperature Melted UHMWPEs

(201) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.5 wt % antioxidants. The antioxidants used were vitamin E, vitamin E acetate, or Irganox 1010 (Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) by first preparing a master batch of antioxidant/UHMWPE blend containing 2 wt % antioxidant with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master batch was diluted to the desired concentration by mixing with virgin GUR 1050 UHMWPE.

(202) An approximately 100 g batch of 0.5 wt % antioxidant-blended GUR 1050 UHMWPE was prepared by separately mixing the three types of 2 wt % antioxidant/GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE (Example 9), which was then mixed with P130 in the amount of 0.9 wt % peroxide. Thus, three separate blends were prepared and tested: (i) 0.5 wt % vitamin E/0.9 wt % P130/GUR 1050 UHMWPE, (ii) 0.5 wt % vitamin acetate/0.9 wt % P130/GUR 1050 UHMWPE, (iii) 0.5 wt % Irganox/0.9 wt % P130/GUR 1050 UHMWPE.

(203) The vitamin E and peroxide-blended UHMWPE batches were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(204) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven.

(205) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14 and 15.

(206) TABLE-US-00013 TABLE 11-1 The physicochemical and tensile mechanical properties of antioxidant-blended, 0.9 wt % peroxide-blended GUR 1050 UHMWPEs before and after further high temperature melting. The antioxidants used were vitamin E, vitamin E acetate and Irganox 1010. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) Vitamin E HTM @ 310 C. 27.1 5.1 124 3 1.4 0.2 39.3 2.2 420 9 99.7 0.7 Vitamin E acetate HTM @ 310 C. 18.1 0.3 102 6 Not- 40.2 2.1 401 11 83.0 3.5 tested Irganox 1010 HTM @ 310 C. 27.4 1.8 116 3 0.5 0.2 39.9 0.8 364 6 87.2 0.6

(207) Both the vitamin E acetate and Irganox-blended, peroxide cross-linked UHMWPEs were lighter in color than the vitamin E-blended, peroxide cross-linked UHMWPE both after compression molding and after high temperature melting.

(208) The OIT, cross-link density and impact strength of vitamin E-acetate blended, peroxide cross-linked UHMWPE were lower than the vitamin E-blended, peroxide cross-linked UHMWPE (Table 11-1). The UTS and EAB did not change considerably between the two antioxidant types.

(209) The wear rate, EAB and impact strength of Irganox-blended, peroxide cross-linked UHMWPE were lower than the vitamin E-blended, peroxide cross-linked UHMWPE. The OIT, cross-link density, and the UTS did not change considerably between the two antioxidant types. These results suggested that peroxide cross-linking and high temperature melting were feasible and effective in cross-linking and improving the oxidation stability in UHMWPE using blending with antioxidants other than vitamin E. Antioxidant and peroxide concentration can be varied together with consolidation parameters and thermal treatment parameters to optimize OIT, UTS strength, Izod strength, and wear.

Example 20

The Use of Irganox 1010 in Peroxide Cross-linked and/or High Temperature Melted UHMWPEs

(210) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.5 wt % Irganox 1010 (Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) by first preparing a master batch of Irganox 1010/UHMWPE blend containing 2 wt % Irganox 1010 with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin GUR 1050 UHMWPE.

(211) An approximately 100 g batch of 0.5 wt % Irganox-blended GUR 1050 UHMWPE was prepared by mixing the 2 wt % Irganox 1010/GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE, which was then mixed with P130.

(212) Medical grade GUR1020 UHMWPE (Celanese, Texas, USA) was blended with 0.5 wt % Irganox 1010 (Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) by first preparing a master batch containing 2 wt % of Irganox 1010 with the aid of isopropyl alcohol (IPA). Then, the master batch was diluted to the desired concentration by mixing with virgin GUR 1020 UHMWPE.

(213) A 100 g batch of the 0.5 wt % Irganox-blended GUR 1020 UHMWPE was mixed with P130 (2,5-dimethyl-2,5-Di-(tbutylperoxy)hexyne-3, also called Luperox 130, peroxide 130 or DYBP) in the amount of 0.9 wt % peroxide.

(214) The Irganox 1010 and peroxide-blended UHMWPE batches were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(215) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven.

(216) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(217) TABLE-US-00014 TABLE 12-1 The physicochemical and tensile mechanical properties of 0.5 wt % Irganox-blended, peroxide cross-linked GUR 1050 UHMWPEs after further high temperature melting at 310 C. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.3 wt % 21.0 48 9 8.8 1.0 50.2 3.7 473 21 123 0.8 peroxide 0.5 wt % >60 127 1 4.3 0.4 44.9 3.0 431 13 95.2 0.9 peroxide 0.6 wt % Not- 94 3 2.5 1.1 Not- Not- 94.5 1.2 peroxide tested tested tested 0.7 wt % 35.9 104 1 1.6 1.4 44.6 1.8 390 7 95.3 0.4 peroxide 0.8 wt % Not- 159 7 2.4 1.4 33.1 4.5 325 19 87.8 0.4 peroxide tested 0.9 wt % 27.4 116 3 0.5 0.2 39.9 0.8 364 6 87.2 0.6 peroxide 1.0 wt % 25.3 155 1 1.0 0.5 Not- Not- 78.8 0.7 peroxide tested tested

(218) For 0.5 wt % Irganox-blended, peroxide cross-linked, high temperature melted UHMWPE, the wear rate, the UTS, the EAB and impact strength generally decreased with increasing peroxide concentration and generally decreased with increasing peroxide concentration (Table 12-1).

(219) As a comparison, 0.075 wt % Irganox-blended, 75 kGy radiation cross-linked UHMWPE typically has an OIT of 3 minutes, a wear rate of 3.6 mg/MC, a UTS of 48.0 MPa, an EAB of 291% and an impact strength of 82 kJ/m.sup.2. It is clear that for a comparable wear rate, the OIT, the EAB and the impact strength would be improved using peroxide cross-linking and high temperature melting.

(220) TABLE-US-00015 TABLE 12-2 The physicochemical and tensile mechanical properties of 0.5 wt % Irganox-blended, peroxide cross-linked GUR 1020 UHMWPEs after further high temperature melting at 310 C. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.9 wt % Not- 143 5 1.5 0.8 36.9 0.8 356 14 80.3 4.4 peroxide tested

(221) Compared to the GUR1050 counterpart as shown in Table 12-1, the 0.5 wt % Irganox 1010-blended, 0.9 wt % peroxide cross-linked GUR1020 UHMWPE exhibited higher cross-link density, higher wear rate, lower UTS, similar EAB and lower impact strength (Table 12-2).

Example 21

The Use of Low Concentrations of Irganox 1010 (0.1 to 0.3 wt %) in Peroxide Cross-linked and/or High Temperature Melted UHMWPEs

(222) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.1 or 0.3 wt % Irganox 1010 (Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate) by first preparing a master batch of Irganox 1010/UHMWPE blend containing 2 wt % Irganox 1010 with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin UHMWPE.

(223) An approximately 100 g batch of 0.1 wt % Irganox-blended GUR 1050 UHMWPE was prepared by mixing the 2 wt % Irganox 1010GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE, which was then mixed with P130 in the amount of 0.3, 0.5, or 0.7 wt % peroxide.

(224) An approximately 100 g batch of 0.3 wt % Irganox-blended GUR 1050 UHMWPE was prepared by mixing the 2 wt % Irganox 1010GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE, which was then mixed with P130 in the amount of 0.3, 0.5, 0.7, or 0.9 wt % peroxide.

(225) The Irganox 1010 and peroxide-blended UHMWPE batches were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(226) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven.

(227) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(228) TABLE-US-00016 TABLE 13-1 The physicochemical and tensile mechanical properties of 0.3 and 0.1 wt % Irganox-blended, peroxide cross-linked GUR 1050 UHMWPEs after further high temperature melting at 310 C. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.3 wt % Irganox 1010 0.3 wt % 42.3 50 2 7.5 1.6 53.4 1.1 550 6 120 0.6 peroxide 0.5 wt % Not- 90 7 Not- 45.8 4.6 465 22 Not- peroxide tested tested tested 0.7 wt % 19.9 116 2 Not- 41.4 1.2 419 10 Not- peroxide tested tested 0.9 wt % 20.0 151 11 1.0 0.5 37.6 4.4 360 19 82.2 1.8 peroxide 0.1 wt % Irganox 1010 0.3 wt % 17.4 91 3 6.1 2.1 51.8 1.7 482 12 109 0.5 peroxide 0.5 wt % 7.9 147 4 2.7 1.1 Not- Not- 91.2 1.3 peroxide tested tested 0.7 wt % Not- 181 3 1.7 0.3 Not- Not- 76.3 2.5 peroxide tested tested tested

(229) For low concentration Irganox-blended, peroxide cross-linked, high temperature melted UHMWPEs (Table 6-1), increasing peroxide concentration led to decreased OIT, increased cross-link density, decreased wear rate, decreased EAB, decreased UTS and decreased impact strength.

(230) As a comparison, 0.075 wt % Irganox-blended, 75 kGy radiation cross-linked GUR1020 UHMWPE typically has an OIT of 3 minutes, a wear rate of 3.6 mg/MC, a UTS of 48.0 MPa, an EAB of 291% and an impact strength of 82 kJ/m.sup.2. It is clear that for a comparable wear rate, the OIT, the EAB and the impact strength would be improved (approximately 44% for EAB and 15% for impact strength using linear intrapolation) using peroxide cross-linking and high temperature melting. A 0.075 wt % Irganox-blended, 0.7 wt % peroxide cross-linked GUR1020 UHMWPE high temperature melted at 310 C. for 5 hours had an OIT of 6.1 minutes, a wear rate of 2.16 mg/MC and an impact strength of 81.8 kJ/m.sup.2.

Example 22

The Effect of Peroxide Concentration on the Properties of Low Vitamin E Concentration (0.1-0.3 wt %) Blended, Peroxide Cross-linked, High Temperature Melted UHMWPE

(231) Medical grade GUR1020 and GUR1050 UHMWPEs (Celanese, Texas, USA) were blended with 0.1, 0.2 or 0.3 wt % vitamin E by first preparing a master batch of vitamin E/UHMWPE blend containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin GUR 1020 or GUR 1050 UHMWPE.

(232) An approximately 100 g batch of the vitamin E-blended UHMWPE of each GUR 1050 and GUR 1020 were prepared by individually mixing the 2 wt % vitamin E master batches with the virgin GUR 1050 or GUR 1020 UHMWPE, which were then mixed with P130.

(233) The vitamin E and peroxide-blended UHMWPE batches were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(234) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven. The test results are shown in Tables 14-1 and 14-2.

(235) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in example 11, 12, 13, 14, and 15.

(236) TABLE-US-00017 TABLE 14-1 The physicochemical and tensile mechanical properties of 0.3, 0.2 and 0.1 wt % Vitamin E-blended, peroxide cross-linked GUR 1050 UHMWPEs after further high temperature melting at 310 C. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.3 wt % Vitamin E 0.8 wt % 33.9 135 2 Not- Not- Not- 93.4 0.6 peroxide tested tested tested 1.0 wt % 19.8 147 15 Not- Not- Not- 83.2 0.5 peroxide tested tested tested 0.2 wt % Vitamin E 0.7 wt % 19.6 117 1 1.0 0.1 42.8 2.8 396 27 94.8 0.8 peroxide 0.9 wt % 17.1 131 12 0.5 0.0 37.4 2.7 344 10 85.2 0.4 peroxide 0.1 wt % Vitamin E 0.5 wt % 8.4 126 2 1.7 0.2 46.1 0.9 393 10 97.1 0.3 peroxide 0.7 wt % 12.0 110 4 0.7 0.1 39.2 2.3 357 8 90.0 0.7 peroxide

(237) TABLE-US-00018 TABLE 14-2 The physicochemical and tensile mechanical properties of 0.2 and 0.1 wt % Vitamin E-blended, peroxide cross-linked GUR 1020 UHMWPEs after further high temperature melting at 310 C. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.2 wt % Vitamin E 0.7 wt % 19.6 135 4 2.4 0.9 39.2 3.0 409 32 91.4 2.1 peroxide 0.9 wt % 29.4 161 2 1.5 0.5 38.7 1.3 367 26 81.7 2.6 peroxide 0.1 wt % Vitamin E 0.5 wt % 18.4 107 1 1.9 0.3 48.4 0.7 429 8 100 0.8 peroxide 0.7 wt % Not- 149 0 1.4 0.4 40.0 3.9 387 8 87.9 1.5 peroxide tested

Example 23

The Effect of Molding Conditions

(238) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.5 wt % vitamin E by first preparing a master batch of vitamin E/UHMWPE blend containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin GUR 1050UHMWPE.

(239) An approximately 100 g batch of 0.5 wt % vitamin E-blended UHMWPE was prepared by mixing the 2 wt % vitamin E master batch with the virgin GUR 1050 UHMWPE, which was then mixed with P130 in the amount of 0.9 wt % peroxide.

(240) The vitamin E and peroxide-blended UHMWPE batch was compression molded on a laboratory press at (i) 190 C. for 2 hours and cooled under pressure to below its melting point, or (ii) 160 C. for 90 minutes followed by 190 C. for 30 minutes resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(241) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven.

(242) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(243) TABLE-US-00019 TABLE 15-1 The physicochemical and tensile mechanical properties of 0.8 wt % vitamin E- blended and 1 wt % peroxide-blended UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Sample Impact Molding OIT CLD Wear UTS EAB Strength Conditions (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 190 C. for 2 hours 27.1 124 3 1.4 0.2 39.3 2.2 420 9 99.7 0.7 160 C. for 90 min + 36.8 159 4 1.4 0.3 50.0 2.8 374 9 91.8 0.2 190 C. for 30 min

(244) The ultimate tensile strength of 0.5 wt % vitamin E-blended, 0.9 wt % peroxide cross-linked GUR1050 UHMWPE was improved by changing the molding conditions (Table 8-1). This was likely the result of improved consolidation achieved when the molding was first performed at the lower temperature (160 C.). The fusing together (or sintering or consolidation) of resin flakes become less efficient with increasing levels of crosslinking. Therefore it is desirable to have consolidation to occur before substantial cross-linking would inhibit further consolidation. The consolidation and the cross-linking will always be in competition during molding of the polymeric material containing cross-linking agent among other additives. One can use lower temperatures to increase rate of consolidation and slow down the rate of cross-linking during molding. When the consolidation was carried out at the higher temperature (190 C.) the crosslinking was likely occurring faster in comparison with the rate of cross-linking in the two-step molding (160 C./190 C.) process; hence the former resulted in lower strength, which is typical of poorly consolidated polymeric material. Ram extrusion is a large-scale consolidation process, where the polymeric material with or without additives is pushed through a heated barrel. Typically the polymeric material consolidates as it travels through the barrel and comes out from the other end of the barrel in a molten state and solidifies under atmospheric pressure. When the cross-linking agent additive is present, it is preferable to have the barrel temperature to be lower at first to ensure good consolidation before substantial cross-linking takes place. The barrel typically has multiple heating zones. The additional heating zones can be used to vary the temperature along the length of the barrel, such that higher temperatures are present after desired level of consolidation takes place as the polymeric material travels through the barrel. In the higher temperature zones of the barrel desired cross-linking level can then be achieved. It is also desirable to actively cool down the barrel near where the polymeric material with the cross-linking agent is delivered into the barrel through a hopper to avoid any premature high rate of cross-linking before consolidation starts.

Example 24

Scale-up Compression Molded Blocks of Vitamin E and Peroxide-blended, Cross-linked UHMWPE

(245) GUR 1020 or GUR1050 UHMWPE was blended on a large scale (approximately 55 lbs of powder resin) with vitamin E and P130.

(246) Approximately 600 grams of each blend was placed in a rectangular mold (approximately 6.1 inches3.25 inches2.1 inches) and compression molded using two temperature regimes. In the first, the temperature of the platen were kept at 160 C. for 2 hours, then raised to and kept at 190 C. for 4 hours under pressure. In the second, the platens were kept at 190 C. for 6 hours under pressure.

(247) After compression molding, the blocks were cut in half. One half was tested as is and the other half was treated using high temperature melting. High temperature melting was performed in nitrogen in a convection oven at 310 C. for 10 hours followed by cooling under nitrogen.

(248) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(249) TABLE-US-00020 TABLE 16-1 The physicochemical and tensile mechanical properties of 0.2 wt % vitamin E-blended and 0.7 wt % peroxide-blended GUR1020 UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Sample Impact Processing OIT CLD Wear UTS EAB Strength Conditions (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 190 C.-6 hrs 18.7 207 5 Not- 48.9 2.9 230 4 70.5 5.6 No HTM tested 190 C.- 6 hrs + 28.6 93 3 2.9 0.3 50.1 2.3 420 16 83.5 4.9 HTM 310 C. 10 hrs 160 C./190 C. 16.0 232 5 Not- 45.1 2.4 321 8 76.9 3.0 No HTM tested 160 C./190 C. + 35.3 106 7 3.0 0.5 50.1 7.1 430 26 98.3 5.6 HTM 310 C. 10 hrs

(250) TABLE-US-00021 TABLE 16-2 The physicochemical and tensile mechanical properties of 0.2 wt % vitamin E- blended and 0.9 wt % peroxide-blended GUR1020 UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Sample Impact Processing OIT CLD Wear UTS EAB Strength Conditions (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 190 C.-6 hrs 18.2 242 26 Not- 31.7 1.4 268 8 63.1 1.4 tested 190 C.- 6 hrs + 29.1 161 3 Not- 36.2 2.5 347 10 80.8 2.7 HTM 310 C. 10 hrs tested 160 C./190 C. 13.8 314 22 Not- 28.1 3.1 251 7 71.6 1.4 tested 160 C./190 C. + 26.9 186 20 0.7 0.1 40.6 4.6 370 9 80.6 0.8 HTM 310 C. 10 hrs

(251) TABLE-US-00022 TABLE 16-3 The physicochemical and tensile mechanical properties of 0.2 wt % vitamin E- blended and peroxide-blended GUR1050 UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. All compression molding was performed using 160 C. for 2 hours followed by 190 C. for 4 hours under pressure. Peroxide Concentration (wt %) and Impact Processing OIT CLD Wear UTS EAB Strength Conditions (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.6 wt % Not- Not- Not- 47.1 4.5 261 8 69.8 1.8 peroxide tested tested tested 0.6 wt % Not- 128 4 Not- 40.1 3.4 386 17 90.1 4.2 peroxide + tested tested HTM 310 C. 10 hrs 0.8 wt % Not- 326 13 Not- 46.4 3.4 216 3 62.0 1.3 peroxide tested tested 0.8 wt % Not- 197 5 1.3 0.2 43.9 2.5 276 7 80.0 2.9 peroxide + tested HTM 310 C. for 10 hrs

(252) These results showed that large scale consolidation by compression molding was feasible. Comparison of the properties of the blocks before and after HTM showed that OIT, UTS, EAB and impact strength were increased by HTM and cross-link density was decreased as expected.

Example 25

Large Scale Ram Extrusion of Antioxidant and Peroxide-containing UHMWPE Followed by High Temperature Melting

(253) GUR 1020 or GUR1050 UHMWPE was blended on a large scale (approximately 55 lbs of powder resin) with vitamin E and P130.

(254) TABLE-US-00023 TABLE 17-1 The resin type, vitamin E concentration and P130 concentration used in the ram extrusion of 2.75 diameter bars of UHMWPE. GUR UHMWPE Vitamin Concentration P130 Concentration Type (wt %) (wt %) 1020 0.2 0.7 1020 0.2 0.9 1050 0.2 0.6 1050 0.2 0.8

(255) The vitamin E and peroxide blends of UHMWPE were ram extruded into 2.75 diameter cylindrical bars, then cut into 10 length for further processing.

(256) High temperature melting of 10-long pieces of extruded bars were performed in a nitrogen convection oven. During high temperature melting the bars were placed and kept at the desired temperature for the desired amount of time, then were cooled down to 40 C. at roughly 2.5 C./min.

(257) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(258) TABLE-US-00024 TABLE 17-2 The physicochemical and tensile mechanical properties of 0.2 wt % vitamin E-blended and peroxide-blended GUR1020 and GUR 1050 UHMWPEs after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. All samples were ram extruded and high temperature melting was performed at 310 C. for 12 hours. Peroxide Impact Concentration UHMWPE OIT CLD Wear UTS EAB Strength (wt %) GUR Type (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 0.9 1020 27.5 179 7 1.3 0.2 41.5 2.7 306 12 76.6 2.9 0.6 1050 27.9 120 7 3.4 0.2 51.1 2.5 386 14 98.9 3.8 0.8 1050 32.0 156 6 1.8 0.2 45.4 3.7 321 12 81.2 2.5

(259) TABLE-US-00025 TABLE 17-3 The physicochemical and tensile mechanical properties of 0.2 wt % vitamin E-blended and 0.8 wt % peroxide-blended GUR 1050 UHMWPEs after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. All samples were ram extruded. HTM HTM Impact Temperature Time OIT CLD Wear UTS EAB Strength ( C.) (hrs) (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) 310 8 36.2 176 8 1.1 0.2 46.4 3.7 307 13 78.8 3.6 315 8 38.5 164 6 1.5 0.1 44.3 3.1 323 10 84.2 0.7 320 6 31.4 190 44 1.2 0.2 49.6 1.9 323 13 83.8 2.4

(260) These results showed that 2.75 diameter bars could be extruded on the large scale with antioxidant and peroxide blends which led to the cross-linking of the bars. In addition, high temperature melting of said bars after extrusion resulted in uniform properties, good wear resistance, high elongation at break and high impact strength. Increasing peroxide concentration decreased impact strength and wear, but these properties could also be manipulated by changing HTM time and temperature.

Example 26

Peroxide Cross-linking and High Temperature Melting with a Peroxide Decomposing at Higher than Consolidation Temperature

(261) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.2 wt % vitamin E (D,L-alpha-tocopherol) by first preparing a master batch of vitamin E/UHMWPE blend containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin GUR 1050 UHMWPE.

(262) An approximately 100 g batch of 0.2 wt % vitamin E-blended GUR 1050 UHMWPE was prepared by mixing the 2 wt % vitamin E/GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE, which was then mixed with peroxide (3,3,5,7,7-pentamethyl-1,2,4-trioxepane, also called Trigonox 311, peroxide 311 or T311) in the amount of 0.8 wt % peroxide.

(263) The vitamin E and peroxide-blended UHMWPE batches were compression molded on a laboratory press (i) at 180 C. for 5 minutes, then cooled under pressure to below its melting point or (ii) at 210 C. for 2 hours and cooled under pressure to below its melting point, resulting in a cylindrical puck with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(264) The resulting pucks were either tested as is or further treated by high temperature melting at 310 C. for 5 hours and then cooling in nitrogen in a convection oven.

(265) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(266) TABLE-US-00026 TABLE 18-1 The physicochemical and tensile mechanical properties of 0.2 wt % vitamin E- blended and 0.8 wt % T311-blended GUR1050 UHMWPEs before and after further high temperature melting. OIT denotes Oxidation Induction time; CLD denotes Cross-link density; UTS denotes Ultimate tensile strength and EAB denotes Elongation at break. Impact OIT CLD Wear UTS EAB Strength Sample (mins) (mol/m.sup.3) (mg/MC) (MPa) (%) (kJ/m.sup.2) Molded at 180 C. Not- 0 0 Not- Not- Not- Not- for 5 minutes tested tested tested tested tested Molded at 180 C. Not- 41 2 Not- 44.0 4.2 524 28 117 3.9 for 5 minutes + tested tested HTM 310 C. for 5 hours Molded at 210 C. Not- 162 2 Not- Not- Not- Not- for 2 hours tested tested tested tested tested Molded at 210 C. Not- 31 8 8.8 2.8 43.2 1.5 599 17 126 3.1 for 2 hours + tested HTM at 310 C. for 5 hours

(267) The 1 hour decomposition temperature of Trigonox 311 used here is reported as 184 C., which is also reported as T.sub.1, indicating that half of the available peroxide will have decomposed in 1 hour at this temperature. The results showed that UHMWPE could be molded in the presence of this peroxide without appreciable cross-linking below this temperature, at 180 C. When the molding temperature was raised to 210 C. above the 1 hour decomposition temperature, there was substantial cross-linking.

(268) In certain embodiments the Trigonox 311 can be mixed with another peroxide that decomposes at a lower temperature, for instance P130. The mixture of P130 and Trigonox 311 at any concentration, for example half-and-half, can be added to the UHMWPE/antioxidant blend prior to consolidation. Some of the cross-linking will occur during consolidation and some of it can occur after consolidation during high temperature treatment.

Example 27

The Wear and Mechanical Properties of Peroxide Cross-linked UHMWPEs

(269) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.1, 0.2, 0.3, 0.5, 0.6, 0.8 Or 1 wt % vitamin E by first preparing a master batch of vitamin E/UHMWPE blend containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin (no additive) GUR 1050 UHMWPE.

(270) An approximately 100 g batch of the vitamin E-blended UHMWPE was prepared by mixing the 2 wt % vitamin E/GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE, which was then mixed with P130 in concentrations of 0.5, 1 or 1.5 wt % P130 peroxide.

(271) The vitamin E and peroxide-blended UHMWPE batch was compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(272) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, and tensile mechanical properties using methods described in Example 11, 12, 13, and 14. For comparison, virgin GUR 1050 UHMWPE with no vitamin E was also blended with P130 at 0.5, 1, or 1.5 wt % P130. These blends were consolidated using the above described molding consolidations. In addition, virgin GUR 1050 and vitamin E/UHMWPE blends with 0.1, 0.2, 0.5 and 1 wt % vitamin E were consolidated and irradiated to 150 kGy at room temperature using electron beam irradiation.

(273) The cross-link density behavior of peroxide cross-linked UHMWPE as a function of increasing vitamin E concentration (FIG. 8) suggested that vitamin E interfered with cross-linking as a free radical scavenger. However, the effect of vitamin E in decreasing the cross-linking efficiency was weaker with peroxide cross-linking compared to that effect with radiation cross-linking (FIG. 8). In addition, at the high vitamin E concentration of 1 wt %, the cross-link density gains by increasing radiation dose were substantially diminished (FIG. 9a), whereas using peroxide cross-linking, it was possible to obtain high cross-link density (FIG. 9b).

(274) TABLE-US-00027 TABLE 19-1 The oxidation induction time (OIT) of vitamin E-blended, peroxide cross-linked UHMWPEs as a function of vitamin E concentration and peroxide concentration. Peroxide concentration (wt. %) Vitamin E concentration 0.5 1.0 1.5 <1 <1 <1 0.1 9 4 8 0.2 12 13 14 0.3 16 17 16 0.5 30 19 21 0.6 38 20 23 0.8 47 27 25 1.0 57 36 29

(275) The OIT of peroxide cross-linked UHMWPE was substantially higher than virgin (no antioxidant), peroxide cross-linked UHMWPE (Table 19-1).

Example 28

Animal Testing to Determine the Peri-prosthetic Effect of Antioxidant-containing Peroxide Cross-linked UHMWPE

(276) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 1 wt % vitamin E by first preparing a master batch of vitamin E/UHMWPE blend containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin GUR 1050 UHMWPE.

(277) An approximately 100 g batch of 1 wt % vitamin E-blended UHMWPE was prepared by mixing the 2 wt % vitamin E/GUR 1050 UHMWPE master batch with the virgin GUR 1050 UHMWPE, which was then mixed with P130 in the amount of 2 wt % P130 peroxide.

(278) The vitamin E and peroxide-blended UHMWPE batch was compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(279) The resulting pucks were either tested as is or further heated to 180, 190 or 200 C. for 5 hours and cooled in a nitrogen convection oven. The pucks were machined into small cylindrical specimens (diameter=5 mm, thickness=2 mm) for further implantation in animals. Controls were machined from 1 wt % vitamin E blended UHMWPE consolidated as described above and used without further annealing.

(280) Control samples had no added peroxide.

(281) Animal implantation and assessment: Short term biological evaluation of the peroxide cross-linked UHMWPE was performed using subcutaneous implantation of these small cylindrical specimens in C57BL/6 mice (n-12). Two implants per group (vitamin E only, consolidated peroxide crosslinked and consolidated/annealed peroxide crosslinked) were implanted each in two mice per time point to be evaluated at 24 weeks, 1 week and 3 weeks of implantation.

(282) At the end of implantation period, the animals were sacrificed and the tissue containing the implants was excised. Multiple sections (approximately every 100 microns) were obtained for histology, stained with Hematoxylin & Eosin and were analyzed by a blinded observer.

(283) There was no observable difference between control samples containing only vitamin E compared to the consolidated and consolidated/annealed samples up to 3 weeks, suggesting that there was no acute inflammatory response specific to peroxide cross-linked UHMWPE in this model.

Example 29

The Effect of Some Consolidation Conditions on Peroxide Cross-linked UHMWPE

(284) Medical grade GUR1020 UHMWPE (Celanese, Texas, USA) was blended with 0.8 wt % vitamin E by first preparing a master batch of vitamin E/UHMWPE blend containing 2 wt % vitamin E with the aid of isopropyl alcohol (IPA) as described above in Example 9. Then, the master blend was diluted to the desired concentration by mixing with virgin (no additive) GUR 1020 UHMWPE.

(285) An approximately 100 g batch of the 0.8 wt % vitamin E-blended UHMWPE was prepared by mixing the 2 wt % vitamin E/GUR 1020 UHMWPE master batch with the virgin GUR 1020 UHMWPE, which was then mixed with P130 in the amount of 1 wt % P130 peroxide.

(286) To determine the effect of molding temperature, the vitamin E and peroxide-blended UHMWPE batch was compression molded on a laboratory press at 190, 230, 245, 270 or 300 C. for 2 hours and cooled under pressure to below its melting point, resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(287) To determine the effect of molding duration, the vitamin E and peroxide-blended UHMWPE batch was compression molded on a laboratory press at 190 C. for 2 hours, 1 hour, 30 minutes or 15 minutes and cooled under pressure to below its melting point, resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(288) Samples were tested to determine crosslink density using methods described in Example 12.

(289) TABLE-US-00028 TABLE 21-1 The effect of molding temperature for vitamin E containing, peroxide cross-linked UHMWPE. Molding was performed for 2 hours. Molding temperature ( C.) Cross-link density (mol/m.sup.3) 190 212 6 230 208 3 245 191 6 270 186 1 300 170 6

(290) The cross-link density of vitamin E containing, P130 cross-linked UHMWPE samples was decreased with increasing molding temperature (Table 21-1). This suggested that the temperature of consolidation is an important factor in determining cross-link density.

(291) TABLE-US-00029 TABLE 21-2 The effect of molding duration for vitamin E containing, peroxide cross-linked UHMWPE. Molding duration (min) Cross-link density (mol/m.sup.3) 120 206 4 60 206 0 30 199 3

(292) The cross-link density of vitamin E containing, P130 cross-linked UHMWPE samples was not changed when the consolidation duration was decreased from 2 hours to 30 minutes for 1 cm-thickness of consolidated sample (Table 21-2).

Example 30

Effect of Gamma Irradiation on Peroxide Cross-linked UHMWPE

(293) Medical grade GUR1050 UHMWPE (Celanese, Texas, USA) was blended with 0.3, 0.5, 0.6, 0.8 or 1 wt % vitamin E by diluting the 2 wt % vitamin E/GUR 1050 UHMWPE master batch of Example 9 with the addition of virgin GUR 1050 UHMWPE.

(294) An approximately 100 g batch of each vitamin E/GUR 1050 UHMWPE blend was mixed with P130 in the amount of 0.5 or 1 wt % peroxide.

(295) The vitamin E and peroxide-blended UHMWPE blends were compression molded on a laboratory press at 190 C. for 2 hours and cooled under pressure to below its melting point, resulting in cylindrical pucks with an approximate diameter of 10.5 cm and a thickness of 1 cm.

(296) The peroxide cross-linked pucks (n=1 each) were vacuum packaged and subsequently subjected the gamma irradiation with an approximate radiation dose of 25 kGy. The properties were tested as is or after gamma sterilization.

(297) Samples were tested to determine oxidation induction time, crosslink density, POD wear rate, and tensile mechanical properties using methods described in Example 11, 12,13 and 14.

(298) TABLE-US-00030 TABLE 22-1 Cross-link density as a function of the vitamin E content for peroxide cross-linked VE/UHMWPE blends pre and post gamma sterilization. Cross-link Density after Cross-link Density before sterilization Vitamin E sterilization (mol/m.sup.3) (mol/m.sup.3) Concentration 0.5 wt % 1 wt % 0.5 wt % 1 wt % (wt %) P130 P130 P130 P130 0.3 249 7 296 8 237 5 288 10 0.5 230 6 297 12 210 4 276 5 0.6 231 4 284 5 208 5 270 4 0.8 218 6 279 10 192 4 255 3 1 207 7 274 5 178 4 241 3

(299) The cross-link density of peroxide cross-linked, vitamin E-blended UHMWPE decreased after gamma irradiation (Table 22-1). Also the wear rates were decreased as a result of gamma irradiation (FIG. 10). These results suggested that peroxide cross-linking and radiation cross-linking of UHMWPE can be used in conjunction.

(300) TABLE-US-00031 TABLE 22-2 Oxidation induction time (OIT) as a function of the vitamin E content for peroxide cross-linked VE/UHMWPE blends pre and post gamma sterilization. Vitamin E OIT before sterilization OIT after sterilization concentration (minutes) (minutes) (wt %) 0.5 wt % P130 1 wt % P130 0.5 wt % P130 1 wt % P130 0.3 16 17 13 14 0.5 30 19 18 22 0.6 38 20 22 20 0.8 47 27 38 25 1 57 36 53 33

(301) The oxidation induction time of peroxide cross-linked, vitamin E-blended UHMWPE was decreased slightly after gamma irradiation, but the OIT values were still very high after gamma irradiation, suggesting that irradiated, peroxide cross-linked UHMWPEs were oxidatively stable in the presence of the antioxidant vitamin E.

Example 31

Prevention of Defect Formation During High Temperature Melting by Cross-linking

(302) Vitamin E blended UHMWPE (0.1 wt %) was obtained as bar stock from Orthoplastics Inc. (Lancashire, UK). Blocks were cut (1066 cm) from the bar stock and gamma-irradiated to 25, 50 or 75 kGy (n=5 each). All blocks and a set of control unirradiated blocks were then high temperature melted in a pre-heated nitrogen convection oven at 320 C. for 6 hours and cooled to about room temperature at about 2.5 C./min. After high temperature melting, the blocks were cut in half through the 10 cm length and visually observed for defects. The defect probability was calculated as the percentage of defects observed for each irradiation dose.

(303) Samples were tested to determine tensile mechanical properties and IZOD impact strength using methods described in Examples 14 and 15.

(304) The defect probability was 0% for 25, 50 and 75 kGy irradiated blocks after high temperature melting compared to 80% for unirradiated UHMWPE. The elongation at break and impact strength of these UHMWPEs were very high due to the high temperature melting (Table 23-1), suggesting they could be further cross-linked without significant loss of mechanical strength and toughness.

(305) TABLE-US-00032 TABLE 23-1 Mechanical properties of irradiated and HTMed vitamin E blended UHMWPEs. High temperature melting was performed at 320 C. for 6 hours. Impact Strength Sample UTS (MPa) YS (MPa) EAB (%) (kJ/m.sup.2) 25 kGy 50.2 0.9 23.2 0.9 765 10 99.4 2.6 50 kGy 53.8 2.3 23.5 0.3 700 7 90.8 2.8 75 kGy 51.0 1.8 22.3 1.4 508 39 99.0 1.6

Example 32

Large Scale High Temperature Melting

(306) GUR1050 UHMWPE was blended on a large scale (approximately 55 lbs of powder resin) with 0.2 wt % vitamin E and 0.765 wt % P130. This vitamin E and peroxide blend of UHMWPE was ram extruded into 4 diameter cylindrical bars, then cut into 4 cm length for further processing.

(307) High temperature melting of 4 cm-thick samples (shaped as hockey pucks) of extruded bars were performed in a nitrogen convection oven. The pucks were placed and were subjected to a heating program as designated below (Table 24-1). After these steps, the oven was cooled to 40 C. in 2 hours and samples were maintained in the oven for 4 hours. Each sample was subjected to either one or multiple steps of heating/soaking with a cooling cycle at the end.

(308) TABLE-US-00033 TABLE 24-1 The sequence of heating/soaking steps and durations for each step. Step 1 Step 2 Step 3 Sample 1 250 C./10 hrs Sample 2 250 C./7 hrs 300 C./12 hrs Sample 3 250 C./4 hrs 300 C./12 hrs 250 C./5 hrs

(309) Samples were tested to determine POD wear rate, tensile mechanical properties, and IZOD impact strength using methods described in Example 11, 12, 13, 14, and 15.

(310) TABLE-US-00034 TABLE 24-2 The mechanical strength, impact toughness and wear rates of peroxide cross-linked, vitamin E-blended, ram extruded UHMWPE before and after HTM using different heating cycles. Impact Strength Wear rate UTS (MPa) EAB (%) (kJ/m.sup.2) (mg/MC) Pre-HTM 46.9 2.0 239 6 63.6 1.1 0.8 0.1 Sample 1 48.6 3.5 263 12 70.3 1.3 Sample 2 52.9 1.4 298 5 78.7 2.2 1.3 0.4 Sample 3 49.8 2.3 292 11 79.7 2.2 1.1 0.1

(311) All UHMWPEs, which were high temperature melted, had higher UTS, EAB, impact strength and wear rates than the control ram extruded bar (Table 24-2). These results suggested that high temperature melting (HTM) improved the mechanical strength, elongation and impact toughness after ram extrusion.

Example 33

Removal of High Temperature Melting by-products

(312) GUR1050 UHMWPE was blended on a large scale (approximately 55 lbs of powder resin) with 0.2 wt % vitamin E and 0.875 wt % P130. This vitamin E and peroxide blend of UHMWPE was ram extruded into 4 diameter cylindrical bars, then cut into 4, 5, or 10 cm length for further processing by high temperature melting and/or extraction.

(313) High temperature melting of different length extruded samples were performed in a nitrogen convection oven, whereby the samples were placed in a nitrogen convection oven and were subjected to a heating program. The heating program started out by slow heating to 250 C. followed by at least one long duration soak at 250 C. followed by slow heat to either 280 or 300 C. followed by a long duration soak (12 hrs) at either 280 or 300 C. After these steps, the oven was cooled to 40 C. in roughly 10 hours.

(314) Thin sections (150 um) were cut using a manual microtome. The thin sections were scanned using an FTIR microscope. The scans were performed every 1 mm from a wavenumber of 400 to 4000 cm.sup.1 at an average of 32 scans. The amount of HTM byproducts was determined by normalizing the area under the absorbance at 1215 cm.sup.1 (1188-1222 cm.sup.1) against the absorbance at 1895 cm.sup.1 (1850-1985 cm.sup.1) after subtracting the respective baselines as is customary in the art.

(315) There were some byproduct detected by the FT IR. These byproducts or residuals were associated with the high temperature melting of peroxide cross-linked UHMWPE using P130. These residuals were quantified by calculating an HTM by-product index and measuring it across blocks of different thickness that underwent the HTM process as seen in FIG. 11.

(316) The residuals were reduced greatly by using thinner blocks during HTM, presumably due to the more efficient diffusion of the residuals out of the blocks. Also, increasing HTM temperature from 280 C. to 300 C. decreased the residuals for 10 cm-thick samples (FIG. 11). It is recommended to increase the temperature and/or duration during high temperature melting to minimize the concentration of the byproduct(s). However if the byproducts are tolerable by the patient then their removal from the polymeric material may not be necessary.

Example 34

Some Annealing Procedures to Reduce by-products from Consolidation and High Temperature Melting

(317) GUR1050 UHMWPE was blended on a large scale (approximately 55 lbs of powder resin) with 0.2 wt % vitamin E and 0.875 wt % P130.

(318) This vitamin E and peroxide blend of UHMWPE was ram extruded into 4 diameter cylindrical bars. High temperature melting (HTM) of the extruded bar (cut into roughly 25 cm-long sections) was performed in a nitrogen convection oven, whereby the bar was placed in a nitrogen convection oven and was subjected to a heating program which included a long duration soak at 320 C. for 7 hours. After this long duration soak, the oven was cooled to 40 C. in roughly 3 hours.

(319) Thin sections (150 um) were cut using a manual microtome which were scanned using a FTIR. The scans were performed every 1 mm from a wave number of 400 to 4000 cm.sup.1 as an average of 32 scans. The amount of HTM by products was determined by normalizing the area under the absorbance at 1215 cm.sup.1 (1188-1222 cm.sup.1) against the absorbance at 1895 cm.sup.1 (1850-1985 cm.sup.1) after subtracting the respective baselines. The control sample before annealing was analyzed in the radial direction (10 cm) from the edge of the thin film that corresponded to the outside surface of the ram extruded rod to the center of the rod.

(320) The roughly 25 cm bar that was processed by HTM was cut into 3 and 5 cm-thick sections and were placed in a convection oven in air at 130 C. One 3 cm-thick section was taken out at 5 days (120 hours) and one 5 cm-thick section was taken out at 3 weeks (504 hours). Thin sections (150 m) were cut in the transverse direction for these 3 and 5 cm-thick samples. The FTIR analysis was performed as described above on thin films by scanning from the edge of the film that corresponded to the center of the cut surface of the ram extruded rod to the other edge of the film in the transverse direction (perpendicular to the radial direction).

(321) There was an HTM byproduct infrared absorbance after HTM, which decreased after annealing at 130 C. (FIG. 12). After 3 weeks, there were no detectable peaks of the HTM byproducts.

(322) After 3 weeks, the ultimate tensile strength was 48.1 MPa, the elongation-at-break was 301% and the IZOD impact strength was 78.4 kJ/m.sup.2.

Example 35

Annealing of Vitamin E-blended, Peroxide Crosslinked, High Temperature Melted UHMWPE in Water

(323) GUR1050 UHMWPE was blended on a large scale (approximately 55 lbs of powder resin) with 0.2 wt % vitamin E and 0.775 wt % P130. This vitamin E and peroxide blend of UHMWPE was ram extruded into 4 diameter cylindrical bars.

(324) High temperature melting (HTM) of the extruded bar was performed in a nitrogen convection oven, the bar was placed in a nitrogen convection oven and was subjected to a heating program which included a long duration soak at 320 C. for 7 hours. After these steps, the oven was cooled to 40 C. in roughly 3 hours.

(325) Thin sections (150 m) were cut using a manual microtome. The thin sections were scanned using a FTIR. The amount of HTM by products was determined by normalizing the absorbance at 1215 cm.sup.1 (1188-1222 cm.sup.1) against the absorbance at 1895 cm.sup.1 (1850-1985 cm.sup.1) after subtracting the respective baselines.

(326) The roughly 25 cm bar that was processed by HTM was cut into 1.8 cm-thick sections and were placed in a convection oven in air or in water at 80 C. Sections were taken out at 18 hours and analyzed as described above.

(327) The HTM by-products detected after high temperature melting and before annealing were decreased on the surface and in the bulk of the 1.8 cm-thick samples after annealing at 80 C. for 18 hours (FIG. 13). Annealing in water was more effective than annealing in air under these conditions.

Example 36

Diffusion of Antioxidant into High Temperature Melted and Irradiated UHMWPE

(328) Virgin UHMWPE blocks (7.343.1 cm) (GUR 1020) were machined from compression molded bar stock. These were subjected to high temperature melting at 320 C. for 6 hours in nitrogen, followed by irradiation to 175 kGy by gamma radiation, denoted as HTM. The virgin UHMWPE irradiated to 100 kGy using gamma radiation served as a control. The irradiated blocks were machined into 1 cm cubes, which were doped in vitamin E with stirring under argon flow at 120 C for 3 hours. The cubes were allowed to cool to room temperature and excess vitamin E was wiped off their surfaces.

(329) After doping, one set of control cubes (n=2) was homogenized under argon, at ambient pressure, at 130 C. for 8 hours. Four sets (n=1, each) of the HTM doped cubes were homogenized at 150 C. for 1 or 2 hours and 180 C. for 30 mins or 1 hour, respectively. The wear and mechanical properties of both the HTM and control samples were measured prior to doping and homogenization.

(330) Another set of controls were irradiated high temperature melted (HTM) blocks (n=1 each) that were melted at 180 and 220 C. for 6 hours to test the effect of high temperature melting on mechanical properties.

(331) Thin sections (150 m) were analyzed by Fourier Transform Infrared Spectroscopy (FTIR) and a vitamin E index was calculated by normalizing the absorbance at 1265 cm.sup.1 (1245-1275 cm.sup.1) by that at 1895 cm.sup.1 (1850-1985 cm.sup.1). The penetration depth of vitamin E was calculated as the depth up to which the vitamin E index of the sample was 0.02.

(332) The penetration depth of vitamin E increased from 1.00.0 mm after doping to 3.80.3 mm for the 100 kGy irradiated control samples homogenized at 130 C. for 8 hours (p=0.003, FIG. 13), while for the HTM samples it increased from 0.90.0 mm after doping to 2.50.0, 3.50.0, 3.00.0 and 4.20.3 mm for samples homogenized at 150 C. for 1 hr, at 150 C. for 2 hours, at 180 C. for 30 minutes and at 180 C. for 1 hour, respectively.

(333) The wear rate of the 100 kGy irradiated control prior to doping, (1.70.2 mg/MC) was comparable to that of 175 kGy irradiated HTMed sample (2.11.3 mg/MC). The elongation-at-break (EAB) and work to failure of the HTM sample prior to doping was higher than the control sample. The ultimate tensile strength (UTS) of the HTM sample prior to doping, was comparable to the control sample. The HTM samples melted at 180 and 220 C. for 6 hours showed significantly higher EAB as compared to the control sample. The UTS of the HTM samples after melting at 180 and 220 C. was slightly lower than the control sample while the work to failure was higher than the control sample.

(334) Increasing the homogenization temperature to 180 C. for the HTMed, irradiated UHMWPE decreased the required homogenization time 8 fold while achieving similar penetration depths compared to the control sample homogenized below the melt. Despite melting at 180 and 220 C., the HTMed, irradiated samples showed improved toughness compared to irradiated control as measured by the tensile work-to-failure (WF) and EAB (Table 28-1). In addition, the wear resistance of the HTMed, irradiated UHMWPE was comparable to the irradiated control, suggesting that HTM before radiation cross-linking followed by doping with vitamin E and homogenization at above-the-melt temperatures may be a feasible alternative to fabricating total joint implants without sacrificing crucial properties.

(335) TABLE-US-00035 TABLE 28-1 Elongation-at-break, UTS and yield strength values of all the test and control samples. Sample EAB (%) UTS (MPa) WF (kJ/m.sup.2) 100 kGy - Control 272 14 46.4 1.2 1557 77 175 kGy - HTM 318 7 43.1 0.8 1758 48 175 kGy - HTM - 292 4 40.1 1.0 1684 75 Melted @ 180 C .-6 h 175 kGy - HTM - 301 4 40.6 0.5 1786 38 Melted @ 220 C.-6 h

Example 37

Two-layer Direct Compression Molded UHMWPE

(336) Medical grade GUR1050 UHMWPE was blended with 0.5 wt % vitamin E by diluting the 2 wt % vitamin E/GUR 1050 UHMWPE master batch of Example 9 with the addition of virgin GUR 1050 UHMWPE.

(337) An approximately 100 g batch of each vitamin E/GUR 1050 UHMWPE blend was mixed with P130 in the amount of 0.9 wt % peroxide.

(338) About 50 grams of virgin UHMWPE powder was placed in the female mold (with push-out plate at the bottom). The contoured male component (FIG. 14) was placed on the powder and the assembled mold was placed in a consolidation press. The powder was pressed at 10 MPa for 3 minutes at ambient temperature. After this time, the mold was removed from the press and the contoured male component was removed. About 10 grams of the vitamin E and peroxide-blended UHMWPE was placed as a second layer on top of the partially consolidated first layer. The mold was closed again and placed between platens pre-heated to 190 C. The final consolidation of the two layers was then performed at 190 C. for 1 hour at 10-25 MPa. Then, the mold was cooled to about room temperature.

Example 38

Consolidation of Cross-linking Agent Blended UHMWPE Using Different Consolidation Conditions

(339) Medical grade GUR1050 UHMWPE was blended with 0.5 wt % vitamin E by diluting the 2 wt % vitamin E/GUR 1050 UHMWPE master batch of Example 9 with the addition of virgin GUR 1050 UHMWPE.

(340) An approximately 300 g batch of each vitamin E/GUR 1050 UHMWPE blend was mixed with P130 in the amount of 0.9 wt % peroxide.

(341) About 100 g of the antioxidant and cross-linking agent-blended UHMWPE powder was placed in a cylindrical mold (diameter 10.5 cm) and placed in between platens preheated to the initial molding temperature in a compression press. Pressure was applied at 15 MPa, which increased during molding up to 25 MPa. The platen temperature was changed after soaking at the initial temperature for a duration 1. The duration for each platen temperature is listed in Table 30-1.

(342) TABLE-US-00036 TABLE 30-1 Initial Duration 1 Final temperature Duration 2 Sample # temperature (min) ( C.) (min) 69 160 15 190 15 71 160 10 190 20 72 160 20 190 10 74 140 90 190 30 76 160 15 230 15 77 140 10 230 15

(343) The resulting cylindrical pucks (diameter 10.5 cm, thickness 1.1 cm) were machined and tested for cross-link density, wear and tensile mechanical properties as described in Examples 12, 13 and 14. The results are shown in Table 30-2. A 75 kGy irradiated and subsequently melted GUR1050 UHMWPE was also tested as control (CISM-75).

(344) TABLE-US-00037 TABLE 30-2 Cross-link density (XLD), wear rate, ultimate tensile strength (UTS) and elongation-at-break (EAB) of 0.5 wt % vitamin E and 0.9 wt % P130- blended GUR1050 UHMWPE using different molding conditions as shown in Table 30-1. Cons. Temp Wear ( C.) XLD (mol/m.sup.3) (mg/MC) UTS (MPa) EAB (%) 0/120 min | 247 4 2.1 0.2 39.9 1.3 270 8 160/190 C. (#44) 120/0 min | 218 3 8.1 1.2 51.5 1.6 283 7 160/190 C. (#45) 15/15 min | 227 2 Not-tested 47.4 1.6 326 5 160/190 C. (#69) 10/20 min | 206 6 Not-tested 42.1 2.9 315 5 160/190 C. (#71) 20/10 min | 186 1 Not-tested 45.8 6.4 326 24 160/190 C. (#72) 90/30 min | 263 1 2.0 0.6 45.4 3.5 252 17 140/190 C. (#74) 15/15 min | 257 4 Not-tested 41.5 2.4 240 8 160/230 C. (#76) 10/15 min | 249 1 Not-tested 40.3 2.4 245 18 140/230 C. (#77) CISM-75 (1050) 247 3 2.5 0.1 45.3 1.5 241 9

(345) Thus, the invention provides methods of manufacturing peroxide cross-linked and high temperature melted polymeric material.

(346) Although the invention has been described in considerable detail with reference to certain embodiments, one skilled in the art will appreciate that the present invention can be practiced by other than the described embodiments, which have been presented for purposes of illustration and not of limitation. Therefore, the scope of the appended claims should not be limited to the description of the embodiments contained herein.