STABLE DISPERSIONS CONTAINING DROPS COMPRISING A GELLING AGENT

Abstract

A dispersion containing a dispersed phase comprising drops and a continuous aqueous phase, preferably in the form of a gel, in which the drops comprise a fatty phase containing at least one gelling agent and a shell, wherein the shell comprises at least one anionic polymer and at least one cationic polymer.

Claims

1. Dispersion containing a dispersed phase comprising drops and a continuous aqueous phase, preferably in the form of a gel, in which the drops comprise a fatty phase containing at least one gelling agent and a shell, wherein the shell comprises at least one anionic polymer and at least one cationic polymer.

2. Dispersion according to claim 1, wherein the gelling agent is chosen from organic or inorganic, polymeric or molecular lipophilic gelling agents; solid fatty substances at ambient temperature and pressure; and their mixtures.

3. Dispersion according to claim 2, wherein the gelling agent is selected from the group consisting of polyacrylates, esters of dextrin and fatty acid(s), glycerol esters of fatty acid(s), polyamides, and mixtures thereof.

4. Dispersion according to claim 3, wherein the esters of dextrin and fatty acid(s) are selected from the group consisting of dextrin palmitates, dextrin myristates, dextrin palmitates/ethylhexanoates, and mixtures thereof.

5. The dispersion according to claim 2, wherein the gelling agents are selected from the group consisting of optionally modified clays, silicas optionally treated hydrophobic, and mixtures thereof.

6. Dispersion according to claim 1, comprising from 0.5% to 99.99% by weight of gelling agent(s) relative to the total weight of the fatty phase.

7. Dispersion according to claim 1, wherein the cationic polymer is a silicone polymer modified with a primary, secondary or tertiary amine function.

8. Dispersion according to claim 1, wherein the cationic polymer has the following formula: ##STR00006## in which: R.sub.1, R.sub.2 and R.sub.3, independently of each other, represent OH or CH.sub.3; R.sub.4 represents a group CH.sub.2 or a group XNH, in which X is a divalent alkylene radical in C.sub.3 or C.sub.4; x is an integer from 10 to 5000; y is an integer between 2 and 1000; and z is an integer between 0 and 10.

9. Dispersion according to claim 1, wherein each drop comprises from 0.01% to 10% by weight of cationic polymer(s) relative to the total weight of the fatty phase.

10. Dispersion according to claim 1, wherein the anionic polymer is a polymer comprising monomeric units having at least one carboxylic acid chemical function.

11. Dispersion according to claim 1, wherein the dispersion comprises from 0.01% to 5% by weight of anionic polymer(s) relative to the total weight of the dispersion.

12. Dispersion according to claim 1, further comprising at least one biological/cosmetic active agent chosen from hydrating agents, cicatrizing agents, depigmenting agents, UV filters, desquamating agents, antioxidants, active agents stimulating the synthesis of dermal and/or epidermal macromoleculars, dermodecontracting agents, antiperspirants, soothing agents and/or anti-aging agents, and mixtures thereof.

13. Dispersion according to claim 1, wherein the average diameter of the drops of the dispersed phase is from 0.2 ?m to 3000 ?m.

14. Dispersion according to claim 1, characterized in that it does not comprise surfactant.

15. Dispersion according to claim 1, comprising at least 5% by weight of glycerin relative to the total weight of the dispersion.

16. Method for preparing the dispersion according to claims 1, comprising the following steps: optionally heating an oily fluid FI at a temperature of from 40? C. to 150? C.; contacting an aqueous fluid FE and the oily fluid FI; and the formation of drops of fatty phase, consisting of the oily fluid FI, dispersed in a continuous aqueous phase, constituted by fluid FE, wherein the drops comprise a shell isolating the core of the drops of the fatty phase of the dispersion, in which: the oily fluid FI comprises at least one cationic polymer, and at least one gelling agent, and the aqueous fluid FE comprises at least water and at least one anionic polymer, in particular a carbomer.

17. Composition comprising a dispersion according to claim 1, in association with a physiologically acceptable medium.

18. Non-therapeutic method for the cosmetic treatment of a keratin material, comprising a step of applying to the keratin material a dispersion according to claim 1.

19. A method for improving the mechanical resistance of drops of a dispersion containing a continuous aqueous phase, and a dispersed fatty phase comprising the drops, said method comprising the use of the dispersion of claim 1, said dispersion comprising at least one fatty phase gelling agent as defined in claim 1.

20. Non-therapeutic method for the cosmetic treatment of a keratin material, comprising a step of applying to the keratin material at least one layer of a cosmetic composition according to claim 17.

Description

EXAMPLES

[0351] Equipment

TABLE-US-00001 Equipment Use 2 syringe pumps Microfluidic device Peristaltic pumps 50 mL glass syringes 25 mL glass syringe Syringe heater 3 3-way valves PTFE capillary 1 device Microfluidic device 1 central tower Supply support 1 stand Microfluidic device support Stirring motor Preparation of the solutions Thermostatic magnetic heating plate Scales Lab consumables Regular use

[0352] Unless otherwise indicated, the compositions described hereinafter result from a microfluidic method, in particular as described in the description or in WO/2010/063937.

Example 1

Preparation of a Dispersion of Drops With or Without the Use of Intermediate Fluid

[0353] This example consisted in preparing a dispersion by a method carried out in the presence of an intermediate phase called MF (Comparative Example 1A) or in its absence (Example 1B according to the invention).

[0354] The compositions of the phases (fluids) allowing the preparation of the dispersions 1A and 1B are as follows:

TABLE-US-00002 1A 1B (comparison) (invention) Fluid Name INCI % w/w % w/w IF Lanol 99 Isononyl SQF* SQF* Isononanoate Rheopearl KL2 Dextrin Palmitate 0.5/5/10 0.5/5/10 KF 8004 Amodimethicone 0.5 0.5 MF Lanol 99 Isononyl 100 Isononanoate OF Osmosis water 83.34 83.34 (? = 811 Glycerol Glycerin 7.00 7.00 pH = Zemea Propanediol 6.00 6.00 3.48) Microcare PTG Pentyleneglycol 2.35 2.35 Microcare PE Phenoxyethanol 0.95 0.95 Carbomer Tego Carbomer 0.24 0.24 340 FD Rhodicare T Xanthan 0.12 0.12 Base Osmosis water Aqua 99.7 99.7 NaOH Sodium 0.3 0.3 Hydroxyde *SQF: sufficient quantity for

[0355] Preparation Protocol

[0356] For the OF: [0357] The carbomer is dispersed in osmosis water and stirred for 2 hours with a pale deflocculant. [0358] Glycerin, Propanediol (Zemea) as well as xanthan are subsequently added. Following these additions, the mixture is stirred for 10 min. [0359] Phenoxyethanol (Microcare PE) and Pentylene Glycol (Microcare PTG) are added. The mixture is stirred for 5 minutes. [0360] Soda is then added. [0361] The last step is to mix the solution for 1 hour. For the base: The soda and water are mixed using a magnetic bar for 5 min.

[0362] For the IF: [0363] Amodimethicone is added to Lanol 99 then mixed with a magnetic bar for 5 min. [0364] The mixture is heated to 80? C. and Rheopearl KL2 is then added with magnetic stirring. [0365] This mixture may then be placed in a water bath heated to 75? C. with magnetic stirring for 1 hour.

[0366] The IF solution heated to 75? C. is introduced into a syringe connected to a heater to keep the solution hot. To reduce heat loss, the microfluidic device was installed directly at the syringe outlet. The amount of gelling agent was modified: 0.5%, 5% and 10% by weight relative to the total weight of the IF phase.

[0367] To stabilize the system, mounting was used one hour after introduction of the IF solution into the syringe.

Example 1A

[0368] In this test 1A (carried out in the presence of an intermediate phase MF), the following flow rates were used:

TABLE-US-00003 OF 240 mL/hr MF 5 mL/hr IF 15 mL/hr Base 28.8 mL/hr

[0369] The presence of the Rheopearl KL2 gelling agent led to an opacification of the drops of the dispersion. In addition, regardless of the gelling agent concentration, the appearance of the drops obtained did not prove to be uniform. It has been demonstrated that according to this method, the gelling agent has not diffused through the MF and has not gelled the fatty phase in its entirety.

Example 1B

[0370] Another test 1B was carried out with IF containing 10% Rheopearl KL2 and without MF intermediate phase, with the following flow rates:

TABLE-US-00004 OF 240 mL/hr MF 0 mL/hr IF 20 mL/hr Base 28.8 mL/hr

[0371] By implementing a method free of intermediate phase, it has been shown that the drops of the final dispersion have a completely uniform appearance.

[0372] The stability over time of the MF-free (i.e. according to the invention) assay system 1B was investigated. For this, a production of the dispersion of drops was carried out under the same conditions as the test 1A and the diameter of the drops was measured over time. An identical diameter throughout the manipulation ensures that no parameters were changed. In fact, a fouling of the nozzle or a viscosity change of the IF would have been automatically detected by a change in the size of the bubbles. The results obtained are as follows:

TABLE-US-00005 TABLE 1 Measurement of diameters during dispersion production including gelled drops Time (min) 5 30 60 120 180 240 300 Mean 1.221 1.200 1.192 1.211 1.213 1.222 1.249 diameter* (mm) Covariance 4.471 2.895 2.885 2.471 2.046 2.586 2.852 (%) *Measurements made on 100 drops

[0373] The covariance of the mean diameters over time is 1.07%. The difference in diameter is negligible.

[0374] The microfluidic method used without MF intermediate phase is stable. It may be assumed that the presence of the oily gelling agent slows the diffusion of the amodimethicone at the water/oil interface and prevents fouling of the nozzle. The use of an intermediate phase is therefore not necessary in contrast to obtaining a microfluidic dispersion with the comparative composition 1A.

Example 2

Mechanical Strength of Drop Dispersions Comprising a Gelling Agent 2.1. Transport Test

[0375] With regard to the mechanical strength of the dispersions according to the invention, a transport test was carried out on a serum sample with 20% of Rheopearl KL2 in the oily phase. For this purpose, a conventional 100 ml receptacle that does not require a specific atmosphere free of air is filled to 50% with the sample.

TABLE-US-00006 Percentage in Final mass Trade name INCI name phase (% m) percentage (% m) Aqueous phase Osmosis water Aqua 86.09% 78.80% Glyc?rine Glycerin 5.80% 5.31% Zemea Butylene glycol 5.00% 4.58% Microcare PTG Pentylenglycol 2.00% 1.83% Rhodicare T Xanthan gum 0.10% 0.09% Microcare PE Phenoxyethanol 0.79% 0.72% Carbomer Tego 340 Carbomer 0.20% 0.18% FD Sodium hydroxyde Sodium 0.03% 0.03% pellets PRS codex hydroxyde Total 100.00% 91.54% Fat phase Lanol 99 Isononyl 79.10% 6.69% isononanoate Rheopearl KL2 Dextrin palmitate 20.00% 1.69% KF 8004 Amodimethicone 0.50% 0.04% Phat Blue DC 6204 CI 61565/CI 0.40% 0.03% 60725 Total 100.00% 8.458% TOTAL 100.00%

[0376] This transport test consists of a round trip Marseille-Paris, by the Post Office.

[0377] It was observed that the drops of the dispersion, subjected to this transport test, were not fragmented: they therefore remained intact despite the use of non-airless packaging.

[0378] 2.2. Rolling Test

[0379] A rolling test was performed on the following two different samples: [0380] 1st sample=dispersion 2A: gelled drops with 10% Rheopearl KL2 in IF (according to the invention) [0381] 2nd sample=dispersion 2B: ungelled drops (without Rheopearl KL2) in the IF (comparative)

[0382] Composition of the 1st Sample:

TABLE-US-00007 % m in the Trade name INCI name phase % m final Aqueous phase Osmosis water Aqua SQF * SQF * Glycerine Glycerine 16.152 14.844 Zemea Propanediol 5.384 4.948 Butyl?ne glycol Butylene glycol 5.384 4.948 Microcare PTG Pentylenglycol 2.146 1.972 Microcare PE Phenoxyethanol 0.858 0.789 Carbomer Tego 340FD Carbomer 0.233 0.214 EDETA Disodium EDTA 0.037 0.034 Sodium hydroxyde pellets Sodium hydroxyde 0.043 0.039 PRS codex Total 100 91.900 FATTY PHASE DUB ININ Isononyl SQF* SQF* isononanoate Rheopearl KL2 Dextrin palmitate 10 0.810 KF 8004 Amodimethicone 0.5 0.041 Phat Blue DC 6204 CI 61565, 0.01 <0.01 CI 60725 Total 100 8.100 Total 100.00 * SQF: sufficient quantity for

[0383] Composition of the 2nd Sample:

TABLE-US-00008 % m in the Trade name INCI name phase % m final Aqueous phase Osmosis water Aqua SQF * SQF * Glycerine Glycerine 16.152 14.844 Zemea Propanediol 5.384 4.948 Butyl?ne glycol Butylene glycol 5.384 4.948 Microcare PTG Pentylenglycol 2.146 1.972 Microcare PE Phenoxyethanol 0.858 0.789 Carbomer Tego 340FD Carbomer 0.233 0.214 EDETA Disodium EDTA 0.037 0.034 Sodium hydroxyde pellets Sodium hydroxyde 0.043 0.039 PRS codex Total 100 91.900 FAT PHASE DUB ININ Isononyl SQF* SQF* isononanoate KF 8004 Amodimethicone 0.5 0.041 Phat Blue DC 6204 CI 61565, CI 60725 0.01 <0.01 Total 100 8.100 Total 100.00 * SQF: sufficient quantity for

[0384] Operating Procedure of the Rolling Test

[0385] A line is traced at 4 cm high on a glass pot 8.5 cm high and 4 cm in diameter. For both samples, the drops were collected up to this limit line. Each pot was then placed at room temperature for 1 week.

[0386] After this time, each jar was gently tilted horizontally and allowed to stand for one hour. They were then placed on the rollers of a roller-mixer. The different rotation cycles were imposed according to the order below:

[0387] 6 rpm for 3 min

[0388] 20 rpm for 3 min

[0389] 30 rpm for 3 min

[0390] 30 rpm for 1 hour

[0391] Visual observation of both samples was performed during the shear to describe the elasticity of the membrane. Another observation was also made between each cycle to study bubble fragmentation.

[0392] Observations

TABLE-US-00009 Dispersion 2B Protocol not Dispersion 2A comprising gelling agent comprising a gelling Protocol (comparative) agent (invention) 6 rpm for 3 min No fragmentation No fragmentation 20 rpm for 3 min No fragmentation No fragmentation 30 rpm for 3 min Slight fragmentation + No fragmentation deformation of the drops. Some drops have a behavior: irreversible deformation reversible deformation 30 rpm for 1 h Strong fragmentation over No fragmentation time The drops remain intact For 25 min, the drops deform for 1 hour and fragment After 25 min: the drops immediately fragment into multiple fine droplets After 40 minutes: It is difficult to distinguish the drops. The drops are almost destroyed.

[0393] It was thus shown that the dispersion 2A according to the invention has a better mechanical strength than the same dispersion 2B devoid of gelling agent.

[0394] 2.3. Ball Test

[0395] Protocol

[0396] A stainless steel ball was placed in a vial of 12 ml containing a composition and the behavior of the drops at the passage of the ball was studied.

[0397] Two vials were thus prepared, respectively comprising the dispersions 2A and 2B described in the rolling test 2.2 above.

[0398] Observations

[0399] The passage of the ball on the composition 2B (comparative) not comprising a gelling agent led to some fragmentation of the ungelled drops. The composition 2A (according to the invention) containing drops comprising a gelling agent was found to be very resistant to the passage of the ball. No deformation or fragmentation was observed for composition 2A. After several passes of the ball, the ungelled sample 2B showed a strong fragmentation that was not observed for the sample 2A with the gelled drops.

Example 3

Preparation of a Care Serum

[0400] The composition 3A (according to the invention) is a composition whose drops of fatty phase comprise a gelling agent. It was prepared from the following phase compositions (see table below):

[0401] Composition 3A

TABLE-US-00010 Fluid Name INCI % w/w OF Osmosis water 67.63 (? = 552 Glycerol Glycerine 17.31 mPa .Math. s Zemea Propanediol 5.77 pH = 4.60) Butyl?ne Glycol Butylene glycol 5.77 Microcare PTG Pentyleneglycol 2.3 Microcare PE Phenoxyethanol 0.92 Carbomer Tego 340 FD Carbomer 0.25 EDETA Disodium EDTA 0.04 NaOH Hydroxyde de 0.01 sodium Base Osmosis water Water 99.5 NaOH Sodium hydroxyde 0.5 IF Lanol 99 Isononyl 89.35 (gelled) Isononanoate Rheopearl KL2 Dextrin Palmitate 10 KF 8004 Amodimethicone 0.5 Phat Black DC 9206 CI 61565, 0.15 CI 60725, CI 26100

[0402] The composition 3B (comparative) is a composition whose fatty phase drops do not comprise a gelling agent. It was prepared from the following phase compositions (see table below):

[0403] Composition 3B

TABLE-US-00011 Fluid Name INCI % w/w OF Osmosis water 67.63 (? = 552 Glycerol Glycerine 17.31 mPa .Math. s Zemea Propanediol 5.77 pH = 4.60) Butylene Glycol Butylene glycol 5.77 Microcare PTG Pentyleneglycol 2.3 Microcare PE Phenoxyethanol 0.92 Carbomer Tego 340 FD Carbomer 0.25 EDETA Disodium EDTA 0.04 NaOH Sodium hydroxyde 0.01 Base Osmosis water Water 99.5 NaOH Sodium hydroxyde 0.5 IF Lanol 99 Isononyl 99.35 (non gelled) Isononanoate KF 8004 Amodimethicone 0.5 Phat Black DC 9206 CI 61565, 0.15 CI 60725, CI 26100 MF Lanol 99 Isononyl 100 Isononanoate

[0404] Protocol of Preparation

[0405] For the OF: [0406] The carbomer is dispersed in the osmosis water and agitated for 2 hours using a pale deflocculator, [0407] Glycerine, Zemea as well as butylene glycol are subsequently added. Following these additions, the mixture is stirred for 10 minutes, [0408] Microcare PE, Microcare PTG and EDETA are added. The mixture is stirred for 5 minutes. [0409] Soda is then added. [0410] The last step is to mix the solution for 1 hour.

[0411] For the Base: The soda and water are mixed using a magnetic bar for 5 min.

[0412] For the Gelled IF: [0413] Amodimethicone is added to Lanol 99 then mixed with a magnetic bar for 5 min. [0414] The mixture is heated to 80? C. and Rheopearl KL2 is then added with magnetic stirring. [0415] Phat Black DC 9206 dye is then added to the composition. [0416] This mixture may then be placed in a water bath heated to 75? C. with magnetic stirring for 1 hour.

[0417] For Ungelled IF:

[0418] The amodimethicone and the Phat Black DC 9206 dye are added to the Lanol 99 and then mixed using a magnetic bar for 5 min.

[0419] The flow rates (in ml/h) used to prepare the compositions 3A and 3B are as follows:

TABLE-US-00012 Composition 3A Composition 3B OF 180 mL/h 180 mL/h MF 5 mL/h IF 20 mL/h 15 mL/h Base 21.6 mL/h 21.6 mL/h

[0420] In the manufacture of composition 3A, the IF and the microfluidic device are maintained at 75? C.

[0421] The pH and viscosity of compositions 3A (invention) and 3B (comparative) were studied over time, at room temperature and at 50? C. The results are provided in the following tables:

TABLE-US-00013 pH/composition 3A: T(day) 1 3 7 14 21 28 56 84 98 112 140 154 TA 5.62 5.68 5.63 5.70 5.67 5.72 5.72 5.70 5.76 5.86 5.80 5.85 50? C. 5.76 5.47 5.56 5.76 5.71 5.72 5.63 5.65 5.67 5.77 5.70 5.75

TABLE-US-00014 pH/composition 3B: T (day) 1 3 7 14 21 28 56 84 98 126 140 154 TA 5.62 5.63 5.70 5.84 5.90 5.89 5.94 5.85 5.88 5.95 5.90 5.92 50? C. 5.52 5.72 5.77 5.79 5.84 5.82 5.75 5.70 5.74 5.82 5.83 5.80

TABLE-US-00015 Viscosity (mPa .Math. s)/composition 3A (10 rpm, 30 sec): T(day) 1 3 7 14 21 28 56 84 98 126 140 154 TA 10140 10360 10200 10620 10560 10380 10200 10000 10360 10400 10500 10700 50? C. 9000 8600 8760 10940 11140 10000 10140 10360 10080 10180 10000 10050

TABLE-US-00016 Viscosity (mPa .Math. s)/composition 3B (10 rpm, 30 sec): T(day) 1 3 7 14 21 28 56 84 98 126 140 154 TA 10400 10300 11060 10240 10040 10220 10100 10040 9680 9920 9950 9980 50? C. 9300 7940 9580 10160 9460 8920 9620 9930 9780 9780 9780 9760

[0422] In view of these results, it has been shown that the composition 3A according to the invention, comprising a gelled fatty phase, has the same change in pH and viscosity as the comparative composition 3B. Both compositions were found to be advantageously stable over time, whether at room temperature or at a temperature of 50? C.

[0423] In addition, regarding the appearance of the drops, no coalescence was observed for the two compositions. Thus, the presence of the gelling agent in the composition 3A does not interact with the aqueous phase and does not disturb the stability of the system.

Example 4

Preparation of a Perfuming Composition

[0424] The perfuming composition of Example 4A (perfume serum) according to the invention is a scented product (which may be sprayed) which is stable over time.

[0425] Composition 4A is a composition whose drops of fatty phase comprise a gelling agent. It was prepared from the following phase compositions (see table below):

TABLE-US-00017 Composition 4A: Fluid Name INCI % w/w OF Osmosis water 95.036 (? = 552 Glycerol Glycerine 1.226 mPa .Math. s Microcare PTG Pentyleneglycol 2.509 pH = 4.60) Microcare PE Phenoxyethanol 0.987 Carbomer Tego 340 FD Carbomer 0.200 EDETA Disodium EDTA 0.040 NaOH Sodium hydroxyde 0.002 Base Osmosis water Water 99.70 NaOH Sodium hydroxyde 0.30 IF Lanol 99 Isononyl 59.50 (gelled) Isononanoate Rheopearl KL2 Dextrin Palmitate 10.00 KF 8004 Amodimethicone 0.50 Technobois Perfumr 30.00

[0426] Composition 4B (comparative) is a composition whose drops of fatty phase do not comprise a gelling agent. It was prepared from the following phase compositions (see table below):

TABLE-US-00018 Composition 4B Fluid Name INCI % w/w OF Osmosis water 95.036 (? = 552 Glycerol Glycerine 1.226 mPa .Math. s Microcare PTG Pentyleneglycol 2.509 pH = 4.60) Microcare PE Phenoxyehanol 0.987 Carbomer Tego 340 FD Carbomer 0.200 EDETA Disodium EDTA 0.040 NaOH Sodium hydroxyde 0.002 Base Osmosis water Water 99.70 NaOH Sodium hydroxyde 0.30 IF Lanol 99 Isononyl 58.50 (not gelled) Isononanoate KF 8004 Amodimethicone 0.50 Technobois Perfume 41.00 MF Lanol 99 Isononyl 100 Isononanoate

[0427] Protocol of Preparation

[0428] For the OF: [0429] The carbomer is first dispersed in the osmosis water and stirred for 2 hours with a pale deflocculator, [0430] The glycerin is subsequently added. Following these additions, the mixture is stirred for 10 minutes, [0431] Microcare PE, Microcare PTG and EDETA are subsequently added. The mixture is stirred for 5 minutes, [0432] The soda is then added, and [0433] The last step is to mix the solution for 1 hour.

[0434] For the Base:

[0435] The soda and water are mixed using a magnetic bar for 5 min.

[0436] For the Gelled IF: [0437] The Lanol 99 and the perfume are first mixed by magnetic stirring (2 min). [0438] The amodimethicone is added and then mixed using a magnetic bar for 5 min. [0439] The mixture is heated to 80? C. and Rheopearl KL2 is then added with magnetic stirring. [0440] This mixture may then be placed in a water bath heated to 75? C. with magnetic stirring for 1 hour.

[0441] For Ungelled IF: [0442] The Lanol 99 and the perfume are first mixed by magnetic stirring (2 min). [0443] The amodimethicone and the Phat Black DC 9206 dye are added and then mixed using a magnetic bar for 5 min.

[0444] The flow rates (in mL/h) used to prepare the compositions 4A and 4B are as follows:

TABLE-US-00019 Composition 4A Composition 4B OF 150 150 MF 4 IF 16 12 Base 10 10

[0445] In the manufacture of composition 4A, the IF and the microfluidic device are maintained at 75? C.

[0446] The pH and the viscosity of the compositions 4A (invention) and 4B (comparative) were studied over time, at room temperature and at 50? C. The results are provided in the following tables:

TABLE-US-00020 pH/composition 4A: T(days) 1 3 7 9 14 21 28 TA 5.99 5.51 5.48 5.51 5.55 5.46 5.58 50? C. 4.91 5.04 5.12 5.27 5.65 5.39 5.51

TABLE-US-00021 pH/composition 4B: T(days) 1 3 7 9 14 21 28 TA 5.15 5.39 5.30 5.39 5.60 5.49 5.52 50? C. 5.53 5.39 5.31 5.36 5.52 5.38 5.35

TABLE-US-00022 Viscosity (mPa .Math. s)/composition 4A (10 rpm, 30 sec): T(days) 1 3 7 9 14 21 28 TA 5390 3030 5850 5950 5550 5380 5280 50? C. 3680 3240 6450 6180 6180 6390 6400

TABLE-US-00023 Viscosity (mPa .Math. s)/Composition 4B (10 rpm, 30 sec): T(days) 1 3 7 9 14 21 28 TA 4180 2740 5330 5180 5490 5350 5180 50? C. 4790 3030 5850 5920 5790 6140 6170

[0447] For perfuming products 4A and 4B, it has been shown that the bubbles are homogeneously distributed in the gel and no coalescence is observed for 3 months.

[0448] In conclusion, the products with gelled bubbles and without gelled bubbles have the same stabilities, pH, viscosities and suspensive powers.

[0449] Example 5

Preparation of a Gel-Cream Composition With a Dye

[0450] The composition of Example 5 is a gel-cream. The composition of Example 5 consists of the following ingredients (see table below):

TABLE-US-00024 % w/w Name INCI name PHASES % w/w AQUEOUS PHASE GEL Osmosis water water SQF * SQF * Microcare PE Phenoxyethanol 0.96 0.86 Microcare Emollient PTG Pentyleneglycol 2.36 2.12 Tego carbomer 340 FD Carbomer 0.32 0.29 Aristoflex Velvet Polyacrylate Crosspolymer-11 0.086 0.077 Rhodicare T Xanthane 0.056 0.050 Cellosize Hydroxyethyl Hydroxyethyl Cellulose 0.027 0.024 cellulose PCG-10 Glycerine codex (99%) Glycerin 5.89 5.27 Zemea Propanediol 2.99 2.68 Butylene Glycol Butylene Glycol 2.95 2.64 EDETA BD Disodium EDTA 0.039 0.035 Sodium Hydroxide Pellets Sodium hydroxide 0.049 0.044 PRS codex Total 100.00 89.62 FATTY PHASE DUB ININ Isononyl Isononanoate SQF * SQF * Rheopearl KL2 Dextrin Palmitate 15.00 1.56 Creasperse White R Titanium Dioxide, Hydrogenated 0.051 0.0053 Polydecene, Hydroxystearic Acid Phat Blue DC 6204 CI 61565/CI 60725 0.0025 0.00026 Nusil CAS 3131 AmodimEthicone 0.20 0.021 Total 100.00 10.38 Total 100.00 *QSP: sufficient quantity for

[0451] The composition of Example 5 is prepared according to the following protocol:

TABLE-US-00025 Outer fluid: OF NAMD INCI NAME % w/w Osmosis water Water 84.26 Glycerine codex (99%) Glycerin 5.89 Zemea Propanediol 2.99 Butylene Glycol Butylene Glycol 2.95 Microcare emollient PTG Pentylenglycol 2.436 Microcare PE Phenoxyethanol 0.96 Tego carbomer 340 FD Carbomer 0.32 Aristoflex Velvet Polyacrylate 0.086 Crosspolymer-11 Rhodicare T Xanthane 0.056 Cellosize Hydroxyethyl Hydroxyethyl Cellulose 0.027 cellulose PCG-10 EDETA BD Disodium EDTA 0.039 Sodium Hydroxide Pellets Sodium hydroxyde 0.049 PRS codex Total 100.00 Inter fluid: IF Name INCI name % w/w DUB ININ Isononyl Isononanoate SQF* Rheopearl KL2 Dextrin Palmitate 15.00 Nusil CAS 3131 Amodimethicone 0.20 Creasperse White R Titanium Dioxide, 0.051 Hydrogenated Polydecene, Hydroxystearic Acid Phat Blue DC 6204 CI 61565/CI 60725 0.0025 Total 100.00 Base: Name INCI name % w/w Osmosis water Water SQF* NaOH Sodium hydroxyde 2.9929 Total 100.00 *SQF: sufficient quantity for

[0452] Operating Mode of the Phases:

[0453] For the OF: [0454] A first phase, called OF1, consists of water and carbomer. This mixture is stirred with a pale deflocculant for 2 hours. [0455] A second phase, called OF 2, is prepared. It consists of glycerin, butylene glycol, Zemea and Rhodicare T. Mixing agitation is performed manually using a spatula for 1min. The objective is to homogeneously disperse the Rhodicare T powder within the phase. [0456] The OF 2 is added, with stirring, to OF1. [0457] Aristoflex Velvet is added to the mixture using a 1% aqueous solution concentrated in Aristoflex Velvet. In the same way, cellosize hydroxyethyl cellulose PCG-10 is incorporated with an aqueous solution concentrated in Cellosize hydroxyethyl cellulose PCG-10 at 0.5% m. Once these 2 compounds are added, the mixture is stirred for 1 hour. [0458] Microcare PE, Microcare PTG and EDETA are subsequently added. The mixture is stirred for 5 minutes. [0459] Soda is then incorporated. [0460] The last step is to mix the solution for 2 hours.

[0461] For the Base:

[0462] The soda and water are mixed using a magnetic bar for 5 min.

[0463] For the FI: [0464] The amodimethicone is added to the DUB ININ then mixed with a magnetic bar for 15 min. [0465] The mixture is heated to 80? C. and Rheopearl KL2 is then added with magnetic stirring. [0466] Phat Black DC 9206 and Creasperse White R are then added, wherein the resulting mixture is mixed with a magnetic bar for 15 minutes. [0467] This mixture may then be placed in a water bath heated to 85? C. with magnetic stirring for 1 hour.

[0468] The flow rates (in mL/h) are as follows:

TABLE-US-00026 OF 150 MF IF 20 Base 2,475

[0469] During the manufacture of the final composition, the IF and the microfluidic device are maintained at 80? C.

[0470] The final composition comprises translucent pale blue dispersed fatty phase drops in a clear, translucent aqueous gel.

Example 6

Preparation of a Hydrating and Anti-Aging Gel-Cream Composition

[0471] The composition below is obtained using a non-microfluidic method (i.e. by emulsification) as previously described).

TABLE-US-00027 Name INCI name % w/w Osmosis water Water 69.02 Microcare PE Phenoxyethanol 0.86 Microcare Emollient PTG Pentyleneglycol 2.12 Tego carbomer 340 FD Carbomer 0.29 Aristoflex Velvet Polyacrylate Crosspolymer-11 0.077 Rhodicare T Xanthane 0.050 Cellosize Hydroxyethyl Hydroxy?thyl Cellulose 0.024 cellulose PCG-10 Glycerine codex (99%) Glycerin 5.27 Zemea Propanediol 2.68 Butylene Glycol Butylene Glycol 2.64 EDETA BD Disodium EDTA 0.035 Sodium Hydroxide Pellets Sodium gydroxyde 0.044 PRS codex DUB ININ Isononyl Isononanoate 8.35 Rheopearl KL2 Dextrin Palmitate 2.01 OriStar RN Retinol 0.5 Vitamin E Acetate Tocopheryl Acetate 0.5 Ceramide II Ceramide NG 0.5 Nikkol VC-IP Ascorbyl Tetraisopalmitate 2 Green Tea Phytolait Camellia Kissi Seed Oil 3 Creasperse White R Titanium Dioxide, Hydrogenated 0.0053 Polydecene, Hydroxystearic Acid Phat Blue DC 6204 CI 61565/CI 60725 0.00026 Nusil CAS 3131 Amodim?thicone 0.021 Total 100.00

Example 7

Preparation of a Gel-Cream Composition With a Dye

[0472] The composition of Example 7 is a gel-cream. The composition of Example 7 consists of the following ingredients (see table below):

TABLE-US-00028 % w/w Name INCI name phases % w/w AQUEOUS PHASE GEL Osmosis water Water SQF * SQF * Microcare PE Phenoxyethanol 0.96 0.86 Microcare Emollient PTG Pentyleneglycol 2.36 2.12 Tego carbomer 340 FD Carbomer 0.32 0.29 Aristoflex Velvet Polyacrylate Crosspolymer-11 0.086 0.077 Rhodicare T Xanthane 0.056 0.050 Cellosize Hydroxyethyl Hydroxy?thyl Cellulose 0.027 0.024 cellulose PCG-10 Glycerine codex (99%) Glycerin 5.89 5.27 Zemea Propanediol 2.99 2.68 Butylene Glycol Butylene Glycol 2.95 2.64 EDETA BD Disodium EDTA 0.039 0.035 Sodium Hydroxide Pellets Sodium hydroxyde 0.049 0.044 PRS codex Total 100.00 89.62 FATTY PHASE DUB ININ Isononyl Isononanoate SQF * SQF * Rheopearl MKL2 Dextrin Myristate 15 2.01 Creasperse White R Titanium Dioxide, Hydrogenated 0.051 0.0053 Polydecene, Hydroxystearic Acid Phat Blue DC 6204 CI 61565/CI 60725 0.0025 0.00026 Nusil CAS 3131 Amodimethicone 0.20 0.021 Total 100.00 10.38 Total 100.00 *SQF: sufficient quantity for

[0473] The composition of Example 7 is prepared according to a protocol identical to that described in Example 5, with the difference that: [0474] the Rheopearl KL2 gelling agent is replaced by the Rheopearl MKL2, [0475] the heating for the preparation of the IF is 90? C., and [0476] during the manufacture of the final composition, the IF and the microfluidic device are maintained at 85? C.

[0477] The flow rates (in ml/h) are identical to those presented in example 5.

[0478] The final composition comprises translucent pale blue dispersed fatty phase drops in a clear, translucent aqueous gel. The dispersed fatty phase of the composition of Example 7 has an improved transparency with respect to that of the composition of Example 5. The Rheopearl MKL2 gelling agent therefore has an advantageous effect in terms of the transparency of the dispersed fatty phase of a composition according to the invention.

Example 8

Preparation of a Gel-Cream Composition

[0479] The composition of Example 8 is a gel-cream. The composition of Example 8 consists of the following ingredients (see table below):

TABLE-US-00029 % w/w Name INCI name PHASES % w/w AQUEOUS PHASE GEL Osmosis water Water SQF* SQF* Microcare PE Phenoxyethanol 0.96 0.86 Microcare Emollient PTG Pentyleneglycol 2.36 2.12 Tego carbomer 340 FD Carbomer 0.32 0.29 Rhodicare T Xanthane 0.056 0.050 Glycerine codex (99%) Glycerin 5.89 5.27 Zemea Propanediol 2.99 2.68 Butylene Glycol Butylene Glycol 2.95 2.64 EDETA BD Disodium EDTA 0.039 0.035 Sodium Hydroxide Pellets Sodium hydroxyde 0.049 0.044 PRS codex Total 100.00 89.62 FATTY PHASE DUB ININ Isononyl Isononanoate SQF* SQF* Rheopearl KL2 Dextrin Palmitate 10.00 1.038 Rheopearl MKL2 Dextrin Myristate 5.00 0.519 Nusil CAS 3131 Amodimethicone 0.20 0.021 Total 100.00 100 10.38 Total 100.00 *SQF: sufficient quantity for

[0480] The composition of Example 8 is prepared according to a protocol identical to that described in Example 5, with the difference that: [0481] the IF is devoid of dye and the IF further comprises Rheopearl MKL2 (addition in the IF made simultaneously with the addition of Rheopearl KL2), and [0482] the preparation of the IF is carried out at 90? C.

[0483] The flow rates (in ml/h) are identical to those presented in example 5.

[0484] The final composition comprises translucent dispersed fatty phase drops in a clear, translucent aqueous gel. The mixture of gelling agents Rheopearl KL2/Rheopearl MKL2 is advantageous compared to Rheopearl KL2 alone in that it makes it possible to obtain a fatty phase of improved transparency.

Example 9

Preparation of a Gel-Cream Composition

[0485] The composition of Example 9 is a gel-cream. The composition of Example 9 consists of the following ingredients (see table below):

TABLE-US-00030 % w/w Name INCI name PHASES % w/w AQUEOUS PHASE GEL Osmosis water Water SQF* SQF* Microcare PE Phenoxyethanol 0.96 0.86 Microcare Emollient PTG Pentyleneglycol 2.36 2.12 Tego carbomer 340 FD Carbomer 0.32 0.29 Rhodicare T Xanthane 0.056 0.050 Glycerine codex (99%) Glycerin 5.89 5.27 Zemea Propanediol 2.99 2.68 Butylene Glycol Butylene Glycol 2.95 2.64 EDETA BD Disodium EDTA 0.039 0.035 Sodium Hydroxide Pellets Sodium hydroxyde 0.049 0.044 PRS codex Total 100.00 89.62 FATTY PHASE DUB ININ Isononyl Isononanoate 5 0.52 Myritol 318 Caprylic/Capric Triglyceride 92.35 9.58 Aerosil R202 silica dimethicone silylate 2.5 0.26 Nusil CAS 3131 Amodimethicone 0.15 0.015 Total 100.00 100 10.38 Total 100.00 * SQF: sufficient quantity for

[0486] The composition of Example 9 is prepared according to a protocol identical to that described in Example 5, with the difference that: [0487] for the FI: [0488] the amodimethicone is added to the DUB ININ and then mixed with a magnetic bar for 15 minutes, [0489] Myritol 318 is added to the mixture by is understood to mean of magnetic stirring, [0490] the mixture is then placed under mechanical stirring using a pale deflocculator, and [0491] Aerosil R202 is then added to the mixture with stirring that is maintained for 20 min. [0492] all stages of preparation of the phases, in particular the IF, as well as the manufacturing method of the composition are carried out at room temperature.

[0493] The flow rates (in ml/h) are identical to those presented in example 5.

[0494] The final composition comprises drops of fat phase dispersed in a translucent colorless aqueous gel. The Aerosil R202 gelling agent is advantageous in that it confers on the fatty phase a thixotropic behavior which allows the manufacture of a dispersion according to the invention by implementing a microfluidic method, all the stages of which are carried out ambient temperature.