Method and Apparatus for Producing Primary Packaging Having an Integrated Septum and Primary Packaging Having an Integrated Septum

Abstract

The invention relates to a method for producing primary packaging having an integrated septum characterised by: a) providing a septum, b) providing an injection-molding die having two die halves, c) positioning the septum in the injection-molding die, d) moving the two die halves of the injection-molding die to form a cavity corresponding to the shape of the primary packaging to be produced, e) injecting a material into the cavity via an injection opening, where the two die halves of the injection-molding die pretensioningly holding the septum, and a rim of the septum is overmolded by the material, f) cooling the injected material while maintaining a holding pressure, g) moving the two die halves of the injection-molding die such that the produced primary packaging means having the integrated septum can be removed from the injection-molding die, and h) removing the produced primary packaging having the integrated septum from the injection-molding die.

Claims

1. A method for producing primary packaging having an integrated septum comprising the steps of: a) providing a septum, b) providing an injection-molding die having two die halves able to be moved relative to one another, c) positioning the septum in the injection-molding die, d) moving the two die halves of the injection-molding die such that a cavity is formed that corresponds to the shape of the primary packaging to be produced, e) injecting a material into the cavity in the injection-molding die via an injection opening in one of the die halves of the injection-molding die, the two die halves of the injection-molding die pretensioningly holding the septum therebetween, and a rim of the septum being overmolded by the material, a region of the septum in contact with the two die halves remaining free of material, f) cooling the injected material while maintaining a holding pressure, as a result of which the primary packaging is formed having an integrated septum, g) moving the two die halves of the injection-molding die such that the produced primary packaging having the integrated septum is removable from the injection-molding die, and h) removing the produced primary packaging having the integrated septum from the injection-molding die.

2. The method according to claim 1, wherein a plastics material is used as the material.

3. The method according to claim 1, wherein the septum is made of an elastomer.

4. The method according to claim 1, wherein before the material is injected, the septum is positioned in a holder of a die half designed as a male mold.

5. The method according to claim 1, wherein before the material is injected, the septum is positioned in a holder of a die half designed as a female mold.

6. The method according to claim 1, wherein a peripheral rim of the septum is overmolded when the material is injected.

7. An apparatus for producing primary packaging comprising an integrated septum according to the method of claim 1, wherein an injection-molding die is provided with two die halves able to be moved relative to one another, one of the die halves being designed as a male mold and the other die half being designed as a female mold, and a holder for the septum being provided on one of the die halves and a stamp being provided on the other die half for pressing the septum against the holder when the material is injected via an injection opening into a cavity.

8. The apparatus according to claim 7, wherein a peripheral channel is provided in the die half designed as a female mold, next to the stamp.

9. The apparatus according to claim 7, wherein the die half designed as a female mold comprises a base and two legs that are positioned substantially perpendicularly thereon, the inner contour of the two legs corresponding to the outer contour of the primary packaging to be produced, and it being possible to move the legs outwardly away.

10. The apparatus according to claim 9, wherein the legs that are positioned substantially perpendicularly on the base are held so as to be movable radially outwardly relative to the base.

11. The apparatus according to claim 7, wherein the outer contour of the die half designed as a male mold corresponds to the inner contour of the primary packaging to be produced.

12. A primary packaging having an integrated septum produced according to the method of claim 1, wherein said primary packaging consists of a plastics material, in which the septum is accommodated in a removal region, the septum separating a pharmaceutical receiving chamber of the primary packaging from the outside thereof.

13. The primary packaging according to claim 12, wherein the removal region comprises a shoulder that faces the receiving chamber.

14. The primary packaging according to claim 12, wherein the primary packaging is provided with a peripheral slope at the end of the pharmaceutical receiving chamber facing the removal region.

15. The primary packaging according to claim 12, wherein the septum comprises a base and a peripheral wall region that is positioned substantially perpendicularly thereon.

16. The primary packaging according to claim 15, wherein the peripheral wall region of the septum comprises an inward-facing slope at the free end of said wall region.

17. The primary packaging according to claim 15, wherein the peripheral wall region of the septum comprises an outward-facing slope at the free end of said wall region.

18. The primary packaging according to claim 12, wherein the septum is provided with spacers on the base thereof.

19. The primary packaging according to claim 12, wherein the septum is provided with a peripheral projection on the base thereof.

20. The primary packaging according to claim 12, wherein an opening is provided at the end opposite the septum.

21. The primary packaging according to claim 12, wherein a flange is provided on the opening arranged opposite the septum.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

[0047] In the drawings:

[0048] FIGS. 1A to 1F show a first embodiment of a method according to the invention for producing primary packaging according to the invention in a first embodiment of an apparatus according to the invention in several method steps,

[0049] FIGS. 2A to 2E show a second embodiment of a method according to the invention for producing primary packaging according to the invention in a second embodiment of an apparatus according to the invention in several method steps,

[0050] FIGS. 3A to 3F show a third embodiment of a method according to the invention for producing primary packaging according to the invention in a third embodiment of an apparatus according to the invention in several method steps,

[0051] FIG. 4 shows a first embodiment of primary packaging according to the invention,

[0052] FIG. 5 shows a second embodiment of primary packaging according to the invention,

[0053] FIG. 6 shows a third embodiment of primary packaging according to the invention, and

[0054] FIGS. 7A to 7C are detailed views of the production of the primary packaging from FIG. 6.

DETAILED DESCRIPTION OF THE INVENTION

[0055] FIG. 1A to 1F show a first embodiment of a method according to the invention for producing primary packaging 1 according to the invention in a first embodiment of an apparatus according to the invention in several method steps.

[0056] FIG. 1A shows two die halves 4, 5 of an injection-molding die 3, one die half 4 being designed as a male mold 9 and the other die half 5 being designed as a female mold 10. The die half 4 designed as a male mold 9 is tapered or sloped at the end thereof facing the other die half 5 and comprises a holder 8 for a septum 2 at this position. In the view in FIG. 1A, a septum 2 has already been placed on said holder 8. The septum 2 at this position comprises a peripheral rim 11 such that the peripheral rim 11 of the septum 2 engages entirely around the holder 8. The die half designed as a male mold 9 is provided with a cap 26 at the end opposite the holder 8, which cap comprises an injection opening via which a plastics material can later be injected into the injection-molding die 3.

[0057] The other die half 5 designed as a female mold 10 consists of a base 5a and legs 5b and 5c that are arranged thereon substantially perpendicular to the base 5a. The legs 5b and 5c can be moved radially outwardly relative to the base 5a. Facing inwards and towards the other die half 4 designed as a male mold 9, a stamp 12 is provided on the base 5a, which stamp is surrounded by a peripheral channel 13. The legs 5a and 5b comprise, at the ends thereof facing the base 5a, an undercut 23 which extends entirely around the inner region of the two legs 5b and 5c. Said undercut 23 makes it possible to produce primary packaging of which the outer contour corresponds to that of the conventional glass cartridges, and therefore the consumer does not have to get used to a different design. This undercut 23 makes it necessary, however, for said legs 5b and 5c to be movable radially outwardly relative to the base 6a so that the primary packaging 1 produced by the apparatus according to the invention can be removed from the injection-molding die 3.

[0058] In FIG. 1B, the die half 4 designed as a male mold 9 has been inserted into the die half 5 designed as a female mold 10 while forming a cavity 6, the cap 26 of the male mold 9 sealing said cavity from the surroundings. It is now possible to inject a material into the cavity 6 via the injection opening 7. As can also be seen from the view in FIG. 1B, the stamp 12 of the base 5a is pressing against the septum such that said septum is securely pressed against the holder 8 of the die half 4 designed as a male mold 9. It should be noted here that the peripheral rim 13 within the base 5a is in part covered by the septum 2. This makes it possible for the septum 2 to be backmolded in this region.

[0059] FIG. 10 shows how the primary packaging 1 is formed after the material has been injected via the injection opening 7 in the injection-molding die 3. It can be clearly seen here that, as a result of the undercut 23, the two die halves 4 and 5 can no longer be simply moved relative to one another in order to remove the primary packaging 1 from the injection-molding die 3. It can also be clearly seen that the peripheral rim 13 of the base 5a is also filled with material and the septum 2 is thus back-molded. After the material has been injected into the cavity 6 and the primary packaging 1 has formed within said cavity 6, a holding pressure or the injection pressure is maintained during a cooling phase until the material of the primary packaging 1 has fallen below its solidification temperature such that the septum 2 cannot become detached from the primary packaging 1 or the position of said septum therein cannot be changed.

[0060] As shown in FIG. 1D, in order to then remove the produced primary packaging 1 from the injection-molding die 3, the two legs 5b and 5c of the die half 5 designed as a female mold 10 are moved radially outwardly relative to the base 5a. As a result, the undercuts 23 release a shoulder 14 of the primary packaging 1 such that the two die halves 4 and 5 can be moved relative to one another such that the die half 4 designed as a male mold 9 is no longer accommodated in the die half 5 accommodated as a female mold 10, as is shown in FIG. 1E.

[0061] FIG. 1F shows how the produced primary packaging 1 according to the invention is then removed from the die half 4 designed as a male mold 9 and can then be further processed.

[0062] FIG. 4 shows primary packaging 1 produced according to the method in FIGS. 1A to 1F in the apparatus shown in these drawings. The opposite ends of the primary packaging 1 can be clearly seen here. An opening 25 for introducing a pharmaceutical in a receiving chamber 16 of the primary packaging 1 is provided at one end. A peripheral flange 17 is also arranged at the ends having the opening 25, making it easier to subsequently handle the primary packaging 1 when it is further processed. A removal region 20 for removing a pharmaceutical introduced in the receiving chamber 16 is arranged at the other end of the primary packaging 1. Said removal region 20 contains a septum 2, which is provided with a peripheral rim 11 in the present case. The septum 2 therefore consists of a base 2a and a wall region 2b, which is positioned substantially perpendicularly on the base 2a in the outer region thereof, extends around the base 2a and forms the peripheral rim 11. The septum 2 comprises, on the base 2a thereof, spacers 19 that are used to easily isolate the septa when the primary packaging 1 is produced. The peripheral rim 11 of the septum 2 is formed having a slope 18 in the rim region thereof facing the receiving chamber 16. Said slope is mainly used during production to more easily place the septum 2 on the holder 8 for the septum at that position. The septum 2 has been back-molded in the region of said slopes 18 such that the septum is thus securely held in the primary packaging 1.

[0063] At the same time, the base 2a of the septum 2 is also overmolded on the region thereof facing away from the receiving chamber 16 such that the septum 2 is also securely held in the primary packaging 1 in this way, too. Furthermore, the primary packaging 1 tapers in the removal region 20 thereof and is therefore provided with a slope 15. The receiving region 20 also comprises a peripheral shoulder 14. As a result of this embodiment having the slopes 15 and the shoulder 14, the primary packaging 1 has a shape that is substantially identical to that of conventional glass cartridges, and a greater market acceptance by pharmaceutical customers is therefore ensured. Furthermore, on account of the same internal shape of the primary packaging 1, the flow behaviour for the liquid or the pharmaceutical within the receiving chamber 16 is substantially identical to the flow behaviour in the conventional glass cartridges.

[0064] FIGS. 2A to 2E show a second embodiment of a method according to the invention for producing primary packaging 101 according to the invention in a second embodiment of an apparatus according to the invention in several method steps.

[0065] FIG. 2A shows two die halves 104, 1055 of an injection-molding die 103, one die half 104 being designed as a male mold 109 and the other die half 105 being designed as a female mold 110. The die half 104 designed as a male mold 109 is tapered or sloped at the end thereof facing the other die half 105 and comprises a holder 108 for a septum 102 at this position. In the view in FIG. 2A, a septum 102 has already been placed on said holder 108. The septum 102 here comprises a peripheral rim 111 such that the peripheral rim 111 of the septum 102 engages entirely around the holder 108. The die half 104 designed as a male mold 109 is provided with a cap 126 at the end opposite the holder 108, which cap comprises an injection opening 107 via which a plastics material can later be injected into the injection-molding die 103.

[0066] The other die half 105 designed as a female mold 110 consists of a base 105a and legs 105b and 105c that are arranged thereon substantially perpendicular to the base 105a. The legs 105b and 105c are stationary in relation to the base 5a. Facing inwards and towards the other die half 104 designed as a male mold 109, a stamp 112 is provided on the base 105a, which stamp is surrounded by a peripheral channel 113.

[0067] In FIG. 2B, the die half 104 designed as a male mold 109 has been inserted into the die half 105 designed as a female mold 110 while forming a cavity 106, the cap 126 of the male mold 109 sealing said cavity 106 from the surroundings. It is now possible to inject a material into the cavity 106 via the injection opening 107. As can also be seen from the view in FIG. 2B, the stamp 112 of the base 105a is pressing against the septum 102 such that said septum is securely pressed against the holder 108 of the die half 104 designed as a male mold 109. It should be noted here that the peripheral rim 113 within the base 105a is in part covered by the septum 102. This makes it possible for the septum 2 to be back-molded in this region.

[0068] FIG. 2C shows how the primary packaging 1 is formed after the material has been injected via the injection opening 107 in the injection-molding die 103. It can be clearly seen here that, as a result of the lack of undercuts similar to those from the apparatus in FIGS. 1A to 1F, the two die halves 104 and 105 can be easily moved relative to one another in order to remove the primary packaging 101 from the injection-molding die 103. It can also be clearly seen that the peripheral rim 113 of the base 105a is also filled with material and the septum 102 is thus back-molded. After the material has been injected into the cavity 106 and the primary packaging 101 has formed within said cavity 106, a holding pressure or the injection pressure is maintained during a cooling phase until the material of the primary packaging 101 has fallen below its solidification temperature such that the septum 102 cannot become detached from the primary packaging 101 or the position of said septum therein cannot be changed.

[0069] As is shown in FIG. 1D, in order to remove the produced primary packaging 101 from the injection-molding die 103, the two die halves 104 and 105 can be moved relative to one another such that the die half 104 designed as a male mold 109 is no longer accommodated in the die half 105 accommodated as a female mold 110, as is shown in FIG. 2D.

[0070] FIG. 2E shows how the produced primary packaging 101 according to the invention is then removed from the die half 104 designed as a male mold 109 and can then be further processed.

[0071] FIG. 5 shows primary packaging 101 which has been produced according to the methods and by means of the apparatus from FIGS. 2A to 2E. In this case, the inner shape of the primary packaging 101 corresponds to that of the primary packaging 1 from FIG. 4. A peripheral slope 115 is also provided that tapers the primary packaging 101 in the removal region 120. The primary packaging 101 does not, however, comprise a shoulder in said removal region 102 in this case; it is therefore possible to use a simpler production method and a simpler production apparatus. The septum 102 in this region again comprises a base 102a on which a peripheral wall region 102b is arranged that forms a peripheral rim 111. Said septum 102 again also comprises, on the base 102a thereof, spacers 119 that are used to easily isolate the septa when the primary packaging 101 is produced. Said septum 102 likewise also comprises a slope 118; however, in this case, said slope extends from the inner region as far as the outer region of the peripheral rim 111. Said slope 118 is used not only to easily place the septum 102 on the holder 108 when the primary packaging 101 is produced. Rather, on account of a slope 118 of this kind, wall thicknesses are avoided in the neck or the removal region 120 and in the receiving region 116 of the primary packaging 101 such that the flow behaviour of the pharmaceutical is not negatively affected. In this respect, it is also ensured that the inner contour or the inner shape of the primary packaging 101 corresponds to that of the conventional glass cartridges.

[0072] FIGS. 3A to 3F show a third embodiment of a method according to the invention for producing primary packaging 201 according to the invention in a third embodiment of an apparatus according to the invention in several method steps.

[0073] FIG. 3A shows two die halves 204, 205 of an injection-molding die 203, one die half 204 being designed as a male mold 209 and the other die half 205 being designed as a female mold 210. The die half 204 designed as a male mold 209 is tapered or sloped at the end thereof facing the other die half 205 and comprises a holder 208 for a septum 202 at this position. In the view in FIG. 3A, a septum 202 has already been placed on said holder 208. The septum 202 here comprises a peripheral rim 211 such that the peripheral rim 211 of the septum 202 engages entirely around the holder 208. The die half designed as a male mold 209 is provided with a cap 226 at the end opposite the holder 208, which cap comprises an injection opening 207 via which a plastics material can later be injected into the injection-molding die 203.

[0074] The other die half 205 designed as a female mold 210 consists of a base 205a and legs 205b and 205c that are arranged thereon substantially perpendicular to the base 205a. The legs 5b and 5c can be moved radially outwardly relative to the base 5a. Facing inwards and towards the other die half 204 designed as a male mold 209, a stamp 212 is provided on the base 205a, which stamp is surrounded by a peripheral channel 213. The legs 205a and 205b comprise, on the outer periphery thereof, a thread 224 which matches pen injection needles that are common on the market such that it is possible to directly mount cannula/injection needles of this kind in keeping with the conventional glass cartridges.

[0075] In FIG. 3B, the die half 204 designed as a male mold 209 has been inserted into the die half 205 designed as a female mold 210 while forming a cavity 206, the cap 226 of the male mold 209 sealing said cavity 206 from the surroundings. It is now possible to inject a material into the cavity 206 via the injection opening 207. As can also be seen from the view in FIG. 3B, the stamp 212 of the base 205a is pressing against the septum 202 such that said septum is securely pressed against the holder 208 of the die half 204 designed as a male mold 209. It can be seen here that the peripheral rim 213 within the base 205a is in part covered by the septum 202. This makes it possible for the septum 202 to be back-molded in this region.

[0076] FIG. 3C shows how the primary packaging 201 is formed after the material has been injected via the injection opening 207 in the injection-molding die 2033. It can be clearly seen here that, as a result of the thread 224, the two die halves 204 and 205 can no longer be simply moved relative to one another in order to remove the primary packaging 201 from the injection-molding die 203. It can also be clearly seen that the peripheral rim 213 of the base 205a is also filled with material and the septum 202 is thus back-molded. After the material has been injected into the cavity 206 and the primary packaging 201 has formed within said cavity 206, a holding pressure or the injection pressure is maintained during a cooling phase until the material of the primary packaging 201 has fallen below its solidification temperature such that the septum 202 cannot become detached from the primary packaging 201 or the position of said septum therein cannot be changed.

[0077] As shown in FIG. 3D, in order to then remove the produced primary packaging 201 from the injection-molding die 203, the two legs 205b and 205c of the die half 205 designed as a female mold 210 are moved radially outwardly relative to the base 205a. As a result, the thread 224 on the primary packaging 201 is released such that the two die halves 204 and 205 can be moved relative to one another such that the die half 204 designed as a male mold 209 is no longer accommodated in the die half 205 accommodated as a female mold 210, as is shown in FIG. 3E.

[0078] FIG. 3F shows how the produced primary packaging 201 according to the invention is then removed from the die half 204 designed as a male mold 209 and can then be further processed.

[0079] FIG. 6 shows primary packaging 201 which has been produced according to the method and by means of the apparatus from FIGS. 3A to 3F. Said primary packaging 201 comprises, in the removal region 220 thereof, a thread 224 which matches pen injection needles that are common on the market such that it is possible to directly mount cannula/injection needles of this kind in keeping with the conventional glass cartridges. In this embodiment of primary packaging 201 too, the inner contour again corresponds to the inner contour of the conventional glass cartridges, leading to identical flow behaviour in this case, too. The septum 202 again also consists of a base 202a and a peripheral wall region 202b, which is formed as a peripheral rim 211 and is again also bevelled at the free end thereof by means of slopes 218. Again, said slopes 218 are also used to more easily mount the septum 202 on the holder 208 of the injection-molding die 203. In addition, this again also prevents wall thicknesses within the receiving chamber 216, which thicknesses could negatively affect the flow behaviour of the pharmaceutical or the liquid that is held in the receiving chamber 216.

[0080] On its base 202a, the septum 202 comprises a peripheral projection 222, which is back-molded by the material when the primary packaging 201 is produced. As a result of this back-molded portion, improved hold of the septum 202 in the primary packaging 201 is achieved. In addition, this also allows any potential pretension in the septum 202 to be better maintained.

[0081] For illustrative purposes, this is shown again in FIGS. 7A to 7C.

[0082] As can be clearly seen in FIG. 7A, the base 202a of the septum 202 is curved and is thus pretensioned. In this view, the septum 202 has already been placed on the holder 208 of the die half 204 designed as a male mold 209. The peripheral leg 202b of the septum 202 engages around the holder 208 by means of the peripheral rim 211 of said leg. The peripheral rim 211 of the septum 202 is again provided with a slope 218, which makes it easier to mount the septum 202 on the holder 208 and also prevents wall thicknesses within the receiving chamber 216 of the eventual primary packaging 201.

[0083] In the view in FIG. 7B, the die half 204 designed as a male mold 209 has been introduced into the other die half 205 designed as a female mold 210. The stamp 212 of the die half 205 presses the septum 202, on the base 202a thereof, against the holder 208 such that the curve shown clearly in FIG. 7A is no longer present. Furthermore, the peripheral projection 222 on the septum 202 and the channel 213 that extends around the stamp 212 can also be seen here.

[0084] FIG. 7C shows the finished primary packaging 201 and the removal region 220 thereof again in detail.

[0085] As can be clearly seen here, the base 202a of the septum 202 is again slightly curved such that said base maintains a certain pretension that consistently seals the septum in a reliably sterile manner. Furthermore, it can also be seen in this view that the peripheral projection 222 on the septum 202 has been overmolded with the material and the septum is thus securely accommodated within the primary packaging 201.

[0086] Having now fully described the present invention in some detail by way of illustration and examples for purposes of clarity of understanding, it will be obvious to one of ordinary skill in the art that the same can be performed by modifying or changing the invention within a wide and equivalent range of conditions, formulations and other parameters without affecting the scope of the invention or any specific embodiment thereof, and that such modifications or changes are intended to be encompassed within the scope of the appended claims.

[0087] When a group of materials, compositions, components or compounds is disclosed herein, it is understood that all individual members of those groups and all subgroups thereof are disclosed separately. Every formulation or combination of components described or exemplified herein can be used to practice the invention, unless otherwise stated. Whenever a range is given in the specification, for example, a temperature range, a time range, or a composition range, all intermediate ranges and subranges, as well as all individual values included in the ranges given are intended to be included in the disclosure. Additionally, the end points in a given range are to be included within the range. In the disclosure and the claims, and/or means additionally or alternatively. Moreover, any use of a term in the singular also encompasses plural forms.

[0088] As used herein, comprising is synonymous with including, containing, or characterized by, and is inclusive or open-ended and does not exclude additional, unrecited elements or method steps. As used herein, consisting of excludes any element, step, or ingredient not specified in the claim element. As used herein, consisting essentially of does not exclude materials or steps that do not materially affect the basic and novel characteristics of the claim. Any recitation herein of the term comprising, particularly in a description of components of a composition or in a description of elements of a device, is understood to encompass those compositions and methods consisting essentially of and consisting of the recited components or elements.

[0089] One of ordinary skill in the art will appreciate that starting materials, device elements, analytical methods, mixtures and combinations of components other than those specifically exemplified can be employed in the practice of the invention without resort to undue experimentation. All art-known functional equivalents, of any such materials and methods are intended to be included in this invention. The terms and expressions which have been employed are used as terms of description and not of limitation, and there is no intention that in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof, but it is recognized that various modifications are possible within the scope of the invention claimed. The invention illustratively described herein suitably may be practiced in the absence of any element or elements, limitation or limitations which is not specifically disclosed herein. Headings are used herein for convenience only.

[0090] All publications referred to herein are incorporated herein to the extent not inconsistent herewith. Some references provided herein are incorporated by reference to provide details of additional uses of the invention. All patents and publications mentioned in the specification are indicative of the levels of skill of those skilled in the art to which the invention pertains. References cited herein are incorporated by reference herein in their entirety to indicate the state of the art as of their filing date and it is intended that this information can be employed herein, if needed, to exclude specific embodiments that are in the prior art.

LIST OF REFERENCE NUMERALS

[0091] 1 primary packaging [0092] 2 septum [0093] 2a base [0094] 2b wall region [0095] 3 injection-molding die [0096] 4 die half [0097] 5 die half [0098] 5a base [0099] 5b leg [0100] 5c leg [0101] 6 cavity [0102] 7 injection opening [0103] 8 holder [0104] 9 male mold [0105] 10 female mold [0106] 11 rim [0107] 12 stamp [0108] 13 channel [0109] 14 shoulder [0110] 15 slope [0111] 16 receiving chamber [0112] 17 flange [0113] 18 slope [0114] 19 spacer [0115] 20 removal region [0116] 21 slope [0117] 23 undercut [0118] 25 opening [0119] 26 cap [0120] 101 primary packaging [0121] 102 septum [0122] 102a base [0123] 102b wall region [0124] 103 injection-molding die [0125] 104 die half [0126] 105 die half [0127] 105a base [0128] 105b leg [0129] 105c leg [0130] 106 cavity [0131] 107 injection opening [0132] 108 holder [0133] 109 male mold [0134] 110 female mold [0135] 111 rim [0136] 112 stamp [0137] 113 channel [0138] 114 shoulder [0139] 115 slope [0140] 116 receiving chamber [0141] 117 flange [0142] 118 slope [0143] 119 spacer [0144] 120 removal region [0145] 121 slope [0146] 125 opening [0147] 126 cap [0148] 201 primary packaging [0149] 202 septum [0150] 202a base [0151] 202b wall region [0152] 203 injection-molding die [0153] 204 die half [0154] 205 die half [0155] 205a base [0156] 205b leg [0157] 205c leg [0158] 206 cavity [0159] 207 injection opening [0160] 208 holder [0161] 209 male mold [0162] 210 female mold [0163] 211 rim [0164] 212 stamp [0165] 213 channel [0166] 214 shoulder [0167] 215 slope [0168] 216 receiving chamber [0169] 217 flange [0170] 218 slope [0171] 219 spacer [0172] 220 removal region [0173] 221 slope [0174] 222 projection [0175] 224 thread [0176] 225 opening [0177] 226 cap