Continuous flow reactor with tunable heat transfer capability

Abstract

A flow reactor fluidic module (12) includes a reactant fluid module (20) having an internal process fluid passage (22) and a first major planar outer surface (24a) and a thermal resistance R between the internal process fluid passage (22) and the first major planar surface (24); a thermal control fluid module (30) having an internal thermal control fluid passage (32) and a second major planar outer surface (34a); a holding structure (50) holding the reactant fluid module (20) and the thermal control fluid module (30); and a gap (25) separating the first major planar surface (24a) from the second major planar surface (34a). The gap (25) comprises an interchangeable or replaceable substance or sheet (26) having a thermal resistance G across the gap (25), wherein G is not equal to R.

Claims

1. A flow reactor fluidic module (12) comprising: a reactant fluid module (20) having an internal process fluid passage (22) and an outer surface (24) comprising a first major planar surface (24a), the reactant fluid module (20) having, at a portion thereof positioned between the internal process fluid passage (22) and the first major planar surface (24a), a thermal resistance R; a first thermal control fluid module (30) comprising an internal thermal control fluid passage (32) and an outer surface (34) comprising a second major planar surface (34a); a holding structure (50) holding the reactant fluid module (20) and the thermal control fluid module (30); and a gap (25) separating the first major planar surface from the second major planar surface, the gap (25) comprising an interchangeable or replaceable substance or sheet (26), the interchangeable or replaceable substance or sheet (26) having a thermal resistance G across the gap (25), wherein G is not equal to R.

2. The fluidic module (12) according to claim 1, wherein G is greater than R.

3. The fluidic module (12) according to claim 2, wherein G is greater than 1.1.Math.R.

4. The fluidic module (12) according to claim 1, the ratio of G to R is in the range of from 0.4 to 1250.

5. The fluidic module (12) according to claim 1, wherein G is in the range of from 2.5.Math.10.sup.5 to 0.05 m.sup.2.Math.K/W.

6. The fluidic module (12) according to claim 1, wherein the gap (25) has an average gap width, the average gap width being in the range of from 1 m to 1 mm.

7. The fluidic module according to claim 1, wherein the reactant fluid module (20) comprises first and second plates (20a,20b) sealed together enclosing the internal process fluid passage (22) and wherein the gap (25) is accessible to allow the interchangeable or replaceable substance or sheet (26) to be interchanged or replaced without disassembly of the reactant fluid module.

8. The fluidic module according to claim 7 wherein the gap (25) is adjustable.

9. The fluidic module according to claim 7 wherein the interchangeable or replaceable substance or sheet (26) comprises a sheet and a thermal grease.

10. The fluidic module according to claim 7 wherein the interchangeable or replaceable substance or sheet (26) consists of air.

11. The fluidic module according to claim 7 wherein the interchangeable or replaceable substance or sheet (26) comprises one or more of a polymer, a metal sheet, a phase change material, a gas, a solid, a liquid, and a multiphase material.

12. The fluidic module according to claim 7 wherein the interchangeable or replaceable substance or sheet (26) comprises a filled polymer.

13. The fluidic module (12) according to claim 7 wherein the outer surface (24) of the reactant fluid module comprises a third major planar surface (24b) and wherein the fluidic module (12) further comprises both (1) a second thermal control fluid module (40) comprising an internal thermal control fluid passage (42) and an outer surface (44) comprising a fourth major planar surface (44a) and (2) a second gap (35) between the third planar surface (24b) and the fourth planar surface (44a).

14. A flow reactor (10) comprising two or more modules according to claim 1, the two or more modules fluidically connected to each other.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

(1) FIG. 1 is a cross-sectional view of a fluidic module for a flow reactor according to embodiments of the present disclosure;

(2) FIG. 2 is a cross-sectional view of another fluidic module for a flow reactor according to embodiments of the present disclosure; and

(3) FIG. 3 is a diagram of a flow reactor comprising two or more fluidic modules according to embodiments of the present disclosure.

DETAILED DESCRIPTION

(4) In the drawings, relative size, position and dimension are for illustration only and not to scale. Plate as defined herein refers to either structure as in a plate-like structure or plate-like half of a larger monolithic structure regardless of the fabrication history of the structure, as well as to plate-like structure which forms, by assembly, with temporary or permanent attachment, a part of a larger structure.

(5) FIG. 1 is a cross-sectional view of a fluidic module for a flow reactor according to embodiments of the present disclosure. With reference to FIG. 1, a flow reactor fluidic module (12) comprises a reactant fluid module (20) having an internal process fluid passage (22) and an outer surface (24), the outer surface comprising a first major planar surface (24a). (In this document, planar is term meaning generally planar, up to and including surface deviation of as great as 2 mm from flat.) The reactant fluid module (20) has, at a portion thereof positioned between the internal process fluid passage (22) and the first major planar surface (24a), a thermal resistance R.

(6) The value of R is determined by R=/k, where is the average thickness of a first plate (20a) or a first half (20a) of the reactant fluid module 20, and k the thermal conductivity of the same plate or half (20a).

(7) The fluidic module (12) further comprises a first thermal control fluid module (30) comprising an internal thermal control fluid passage (32) and an outer surface (34), the outer surface comprising a second major planar surface (34a); a holding structure (50) holding the reactant fluid module (20) and the thermal control fluid module (30); and a gap (25) separating the first major planar surface from the second major planar surface. The gap (25) comprises an interchangeable or replaceable substance or sheet (26). The interchangeable or replaceable substance or sheet (26) in the gap has a thermal resistance G across the gap (25), and G is not equal to R, or, alternatively, the interchangeable or replaceable substance or sheet is consists of a material or materials different from a material materials which the reactant fluid module (20) comprises.

(8) The value of G is determined by G=/k, where is the average thickness of the material (26) in the gap (25) and k is the thermal conductivity of the material (26).

(9) Desirably, G is greater than R, greater than 1.1.Math.R, greater than 1.2.Math.R, greater than 1.5.Math.R, greater than 1.8.Math.R, and/or even greater than 2.Math.R. The ratio of G to R desirably is in the range of from 0.4 to 1250, within the range of from 1 to 800, or even within the range of from 1.1 to 100, and G itself is desirably in the range of from 2.5.Math.10.sup.6 to 0.05 m.sup.2.Math.K/W, or even in the range of form 2.5.Math.10.sup.4 to 0.01 m.sup.2.Math.K/W. These desirable conditions are desirable in certain situations, not required.

(10) The gap (25) has an average gap width, and the average gap width is in the range of from 1 m to 1 mm, or even in the range of in the range of from 10 m to 0.2 mm.

(11) The reactant fluid module (20) comprises first and second plates (20a,20b) sealed together enclosing the internal process fluid passage (22). In some embodiments, the first and second plates (20a,20b) are permanently sealed together. Similarly to the reactant fluid module (20), thermal control fluid module (30) comprises first and second plates (30a,30b) sealed together enclosing the internal thermal control fluid passage (32). In some embodiments, the first and second plates (30a,30b) of the thermal control fluid module (30) are not permanently sealed together. Because the reactant fluid module (20) is sealed and encloses the internal process fluid passage (22), the gap (25) is accessible to allow the interchangeable or replaceable substance or sheet (26) to be interchanged or replaced without disassembly of the reactant fluid module (20). Because the thermal control fluid module (30) is sealed and encloses the internal thermal control fluid passage (32), the gap (25) is accessible to allow the interchangeable or replaceable substance or sheet (26) to be interchanged or replaced without disassembly of the thermal control fluid module (30).

(12) According to embodiments, the width of the gap may be adjustable, such as by changing the relative mounted positions of the reactant fluid module (20) and the thermal control fluid module (30). According to embodiments, such adjustment may also be achieved by inserting an interchangeable or replaceable substance or sheet (26) having a different thickness than the immediately prior interchangeable or replaceable substance or sheet, particularly if the holding structure is designed to press the modules (20,20) together. Alternatively, the gap (25) may be of constant size, but various materials may be placed in the gap to change the value of G.

(13) The interchangeable or replaceable substance or sheet (26) can comprise a sheet and a thermal grease, one or more of one or more of a polymer, a metal sheet, a ceramic sheet, a glass sheet, a phase change material, a gas, a solid, a liquid, and a multiphase material, or a filled polymer. The interchangeable or replaceable substance or sheet (26) can simply consist of air.

(14) FIG. 2 is a also cross-sectional view of a fluidic module for a flow reactor according to embodiments of the present disclosure. With reference to FIG. 2, according to embodiments such as that shown in FIG. 2, the reactant fluid module comprises a third major planar surface (24b) and the fluidic module (12) further comprises both 1) a second thermal control fluid module (40) comprising an internal thermal control fluid passage (42) and an outer surface (44) comprising a fourth major planar surface (44a) and 2) a second gap (35) between the third planar surface (24b) and the fourth planar surface (44a). The dual-side configuration of the embodiment of FIG. 2 maximizes the heat transfer performance of the module and better simulates conditions in dual-side production size flow reactor modules.

(15) FIG. 3 is a diagram of a flow reactor comprising two or more fluidic modules according to embodiments of the present disclosure. In FIG. 3, a flow reactor (10) comprises two or more modules (12) of the type disclosed herein. Using modules (12) in reactor (10) allows reactor (10), even if small in scale, to closely match the thermal performance of larger production-size flow reactors of various sizes by increasing G sufficiently to make the volumetric heat transfer coefficient within module (12) fall within 5, 10, or 20% of the value of the calculated (or measured) volumetric heat transfer coefficient in a larger size reactor intended for production.

(16) Desirably, both the first and second plates (20a,20b) of the reactant fluid module (20) and the first and second plates (30a,30b) of the first thermal control fluid module (30) (as well as the plates (40a,40b) of the second thermal control fluid module (40), if present) are formed of a high thermal conductivity material. This provides the widest range of adjustability in the thermal performance of the module (12). The plate material desirably has a thermal conductivity of at least 15 W/m.Math.K at 20 C., at least 20 W/m.Math.K at 20 C., at least 30 W/m.Math.K at 20 C., or even at least 60 W/m.Math.K at 20 C. or greater.

(17) Desirably, the first and second plates (20a,20b) of which the reactant fluid module (20) is formed, comprise or even consist of silicon carbide. This allows the module (12) to resist the broadest range of chemical environments, including high temperature strongly basic environments which will easily dissolve most glass. The ability provided by the present disclosure to adjust G and make G greater than R is even more important in this instance because otherwise the high thermal conductivity of silicon carbide makes the reaction environment in a small scale reactor, in particular the thermal performance of the small scale reactor, much too high relative to the performance of a large scale reactor. Without the ability to increase G, thermally sensitive reaction process designed and optimized in a small scale SiC flow reactor will not scale directly and simply to a large scale SiC flow reactor. Merely reducing flow rate of thermal fluids and/or reactant fluids does not work. With the ability to increase (or reduce) G selectively, quickly, easily, and inexpensively, independent of flow rates, as provided by the embodiments of the present disclosure, a single small laboratory or pre-production SiC reactor can match the various levels of thermal performance of reactors of various materials and various sizes, as needed.

(18) The methods and/or devices disclosed herein are generally useful in performing any process that involves mixing, separation, extraction, absorption, distillation, crystallization, precipitation, or otherwise processing fluids or mixtures of fluids, including multiphase mixtures of fluidsand including fluids or mixtures of fluids including multiphase mixtures of fluids that also contain solidswithin a microstructure. The processing may include a physical process, a chemical reaction defined as a process that results in the interconversion of organic, inorganic, or both organic and inorganic species, a biochemical process, or any other form of processing. The following non-limiting list of reactions may be performed with the disclosed methods and/or devices: oxidation; reduction; substitution; elimination; addition; ligand exchange; metal exchange; and ion exchange. More specifically, reactions of any of the following non-limiting list may be performed with the disclosed methods and/or devices: polymerisation; alkylation; dealkylation; nitration; peroxidation; sulfoxidation; epoxidation; ammoxidation; hydrogenation; dehydrogenation; organometallic reactions; precious metal chemistry/homogeneous catalyst reactions; carbonylation; thiocarbonylation; alkoxylation; halogenation; dehydrohalogenation; dehalogenation; hydroformylation; carboxylation; decarboxylation; amination; arylation; peptide coupling; aldol condensation; cyclocondensation; dehydrocyclization; esterification; amidation; heterocyclic synthesis; dehydration; alcoholysis; hydrolysis; ammonolysis; etherification; enzymatic synthesis; ketalization; saponification; isomerisation; quaternization; formylation; phase transfer reactions; silylations; nitrile synthesis; phosphorylation; ozonolysis; azide chemistry; metathesis; hydrosilylation; coupling reactions; and enzymatic reactions.