Keratolytic composition with anti-allergic anti-inflammatory properties

Abstract

A product with an enhanced medicinal and cosmetic composition with a specific utility of Psoriasis, Eczema and like skin disorders application is characterized by the fact that it comprises active agents and ingredients as vanilla extract, ammonium chloride, potassium chloride and quaternary ammonium compound having formulated at a specific pH value with other specially selected adjuvants and fillers.

Claims

1. A method of treating a skin disorder, the method comprising: administering to an area of skin exhibiting the skin disorder a composition comprising: active components that treat the skin disorder, the active components that treat the skin disorder consist of: at least one of vanilla extract, vanilla oil and vanillin in an amount of from about 0.1% to less than 2% by weight of the composition; quaternary ammonium in an amount from about 0.001% to about 40% by weight of the composition; and a cation chloride salt in an amount from about 0.001% to about 10% by weight of the composition, the cation chloride salt being selected from the group consisting of ammonium chloride and potassium chloride, wherein the skin disorder is selected from the group consisting of psoriasis, eczema, dermatitis, acne, and dandruff, and the pH of the composition is greater than about 3.0 and less than about 7.0.

2. The method of claim 1, comprising topically administering the composition on a daily basis for at least 4 days, to an area of skin exhibiting the disorder.

3. The method of claim 1, wherein the composition is topically administered in the form of a lotion, cream, ointment, emulsion solution, patch, pad, cleanser, conditioner, gel, soap, sprays, foam, or tape.

4. The method of claim 1, wherein the composition is a pharmaceutical or cosmetic preparation.

Description

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS OF THE INVENTION

(1) Natural vanilla has used for generations as flavoring in foods, drinks and medicines. Vanilla beans were an antidote for certain venomous bites. It was used for respiratory pain and congestion, deep coughs, stomach ailments etc. Presently vanilla finds its way mostly into food, cosmetic and medicines as flavoring agent and into perfumes and some medicines for its aromatic properties as mood enhancer/stimulant.

(2) In the beginning of 1900s it was observed that workers who handled the pods of Vanilla Planifolia have developed dermatitis of the hands and face. Similar finding have been report by many others like Hutchinson (1892), Maiden (1912), White (1934), Downing (1939). This dermatitis was named as Vanillasim. May be because of these finding it was never been used to cure any skin diseases. But most of the above findings are based on actual handling of vanilla pods, vines, plants.

(3) In the present invention it has been found that when vanilla extract is used in the cleansing liquid where quantity is very minimal (say <2%) it exhibits an anti-allergic and anti-inflammatory effect on the skin in patients who suffer with psoriasis.

(4) Most of the cleansing agents contain sodium chloride and/or ammonium chloride and/or potassium chloride. In the present invention it was found that when ammonium chloride is used along with other gentle surfactants like sodium laureth sulfate and ammonium laureth sulfate it was showing keratolytic properties by removing scales in psoriasis effected patients. The same test has been repeated by using sodium chloride in the place of ammonium chloride and found that it was not having keratolytic properties.

(5) Ammonium chloride is being used presently in the cleansing liquids etc, but it has not been used as an ingredient specifically to provide a therapy for prevention, reduction and relief of scaling of allergic and/or autoimmune skin diseases. In addition to ammonium chloride other quartemary ammonium compounds, such as benzalkonium chloride, benzethonium chloride, cetalkonium chloride, cetrimide, cetrimonium bromide, cetylpyridinium chloride, glycidyl trimethyl, stearalkonium chloride, and the like can be used to like effect.

(6) Though the actual mechanism is not understood, it was tested on 5 different patients with different climatic conditions and observed that cleansing composition containing ammonium chloride and/or ammonium surfactants and/or quarternary ammonium compounds exhibited keratolytic properties. Composition started showing anti-allergic and anti-inflammatory properties when natural vanilla extract was used in the composition.

(7) It was also observed that composition exhibited better results when moisturizing natural extracts and/or oils like chamomile, sunflower, coconut etc are used in the composition preparation.

(8) It was observed that vanilla, ammonium chloride and/or ammonium surfactants and/or quarternary ammonium compounds and other natural extracts like chamomile, sunflower, coconut etc exhibit keratolytic effect along with anti-allergic and anti-inflammatory effects and moisturizing the skin.

(9) In order to illustrate the invention in detail, representative Examples will be given as hereunder although the invention is not limited thereto.

Example 1

(10) For scalp cleansing composition:

(11) TABLE-US-00001 Ammonium Laureth Sulfate 28-30% Sodium Laureth Sulfate 1-2% Coamidopropylbetain 2-3% Ammonium Chloride 0.50-1% Tetrasodium EDTA 0.25-1% DMD Hydantoin 0.10-0.40% Citric Acid 0.10-0.40% Dye 0.20-0.40% Vanilla Extract 0.10-0.30% Chamomile Extract 0.10-0.30% Sunflower Extract 0.10-0.30% Deionised water To make quantity to 100%

Example 2

(12) For Scalp Cream:

(13) TABLE-US-00002 Ammonium Chloride 0.50-2% Potassium Chloride 0.50-2% Citric Acid 0.10-2% Vanilla Extract 0.10-0.50% Chamomile Extract 0.10-0.50% Coconut Oil 10-20% Starch 20-30% White Soft Paraffin 30-40% Phenoxyethanol 1-3% Deionised water To make quantity to 100%

Example 3

(14) For Body Lotion:

(15) TABLE-US-00003 Ammonium Chloride 0.50-2% Potassium Chloride 0.50-2% Citric Acid 0.10-2% Vanilla Extract 0.10-0.50% Chamomile Extract 0.10-0.50% Phenol 0.10-0.50% Talcum 15-20% Zinc Oxide 5-10% Glycerin 7.5-15% Alcohol 20-30% Deionised water To make quantity to 100%

(16) Inventor himself is a psoriasis patient for the last 8 years. He tried all topical applications like salicylic acid, coal tar, steroid based etc and experienced all sorts of side effects associated with these presently available treatments.

(17) This invention is lead by desire for developing a new and innovative treatment, which can be used in the longer periods of time without side effect associated with other products. The Topical Composition given in the example being used for more than 6 months and also tested on other psoriasis patients with encouraging results.

(18) These compositions are convenient to use, cost effective compared to other preparations and most of all these can be used for longer periods of time without side effects.

(19) The responsive time to the treatment may be different for each individual patient and depends upon the severity of the lesions. Typically some improvement is visible after 3-4 days after initiation of treatment.

(20) Though the exact mechanism of action of quaternary ammonium compounds, such as ammonium chloride, and vanilla is not fully understood, actual testing on psoriasis patients have shown encouraging results without side effects associated with steroids and other presently available psoriasis topical applications.

(21) It is also understood that each of above active ingredients described above, or two or more together may also find a useful application in other types of methods differing from the type described above.

(22) While certain novel features of this invention have been shown and described and mentioned in the claims, it is not intended to be limited to the details above, since it will be understood that various omissions, modifications, substitutions and changes in the forms and details of the device illustrated and in its operation can be made by those skilled in the art without departing in any way from the spirit of the present invention.