Ocular eyelid scrub composition for the treatment of demodex blepharitis

Abstract

A composition for the treatment of Demodex blepharitis containing tea tree oil and/or Neem oil and coconut oil in glycerol or in water or in a mixture of glycerol and water. The composition may further contain aloe barbadensis gel, sodium lauryl sulfate, cocoamidopropyl betaine, lauroyl glucoside, or DMDM hydantoin, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water. The composition is used to treat Demodex blepharitis by applying the composition to the eyelid margin and eyelashes and scrubbing the eyelid margin, eyelashes, and eyelash roots with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

Claims

1. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO), 0.1-10% v/v, or Neem oil, 0.1-95% v/v, coconut oil, 1-10% v/v, aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5%, w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside, 1% to 10% w/v, or DMDM hydantoin, 0.1 to 5% v/v, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water.

2. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO), 0.1-10% v/v, or Neem oil, 0.1-95% v/v, coconut oil, 1-10% v/v, aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5% w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside, 1% to 10% w/v, and DMDM hydantoin, 0.1 to 5% v/v, in glycerol or in water or in a mixture of glycerol and water.

3. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO), 0.1-10% v/v, and Neem oil, 0.1-95% v/v, and coconut oil, 1-10% v/v, aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5%, w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside 1% to 10% w/v, or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water.

4. A composition for the treatment of Demodex blepharitis, comprising: tea tree oil (TTO), 0.1-10% v/v, and Neem oil, 0.1-95% v/v, and coconut oil, 1-10% v/v, aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5% w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside, 1% to 10% w/v, and DMDM hydantoin, 0.1 to 5% v/v, in glycerol or in water or in a mixture of glycerol and water.

5. A method for treating Demodex blepharitis, comprising the steps of: 1) providing a composition comprising tea tree oil (TTO), 0.1-10% v/v, or Neem oil, 0.1-95% v/v, and coconut oil, 1-10% v/v, in glycerol or in water or in a mixture of glycerol and water; 2) applying said composition to the eyelid margin and eyelashes; and 3) scrubbing the eyelid margin, eyelashes, and eyelash roots with said composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

6. The method of claim 5, wherein said composition further comprises: aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5%, w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside, 1% to 10% w/v, or DMDM hydantoin, 0.1 to 5% v/v, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water.

7. The method of claim 5, wherein said composition further comprises: aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5% w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside, 1% to 10% w/v, and DMDM hydantoin, 0.1 to 5% v/v, in glycerol or in water or in a mixture of glycerol and water.

8. A method for treating Demodex blepharitis, comprising the steps of: 1) providing a composition comprising: tea tree oil (TTO), 0.1-10% v/v, and Neem oil, 0.1-95% v/v, and coconut oil, 1-10% v/v, in glycerol or in water or in a mixture of glycerol and water; 2) applying said composition to the eyelid margin and eyelashes; and 3) scrubbing the eyelid margin, eyelashes, and eyelash roots with said composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

9. The method of claim 8, wherein said composition further comprises: aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5%, w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside 1% to 10% w/v, or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or in water or in a mixture of glycerol and water.

10. The method of claim 8, wherein said composition further comprises: aloe barbadensis gel, 0.1 to 10% v/v, sodium lauryl sulfate, 0.5 to 5% w/v, cocoamidopropyl betaine, 0.1 to 5% v/v, lauroyl glucoside, 1% to 10% w/v, and DMDM hydantoin, 0.1 to 5% v/v, in glycerol or in water or in a mixture of glycerol and water.

Description

BEST MODES FOR CARRYING OUT THE INVENTION

(1) While the following description details the preferred embodiments of the present invention, it is to be understood that the invention is not limited in its application to the details of the disclosures and descriptions in the accompanying specification, since the invention is capable of other embodiments and of being practiced in various ways.

(2) The present invention provides an increased, improved effectiveness of tea tree oil (TTO) or Neem oil, or a combination thereof, on the eyelid by combining these compounds with coconut oil. Coconut oil is active as an anti-microbial and moisturizer. Addition of other key ingredients can further improve the effectiveness of tea tree TTO and/or Neem oil on the eyelid. TTO is formulated at 0.1-10%, preferably 1%, v/v, Neem oil is formulated at 0.1-95%, preferably 10%, v/v, and coconut oil is formulated at 1-10%, preferably 3%, v/v, in substances such as glycerol or water or a mixture of glycerol and water. Other ingredients that can be combined with TTO and/or Neem oil and coconut oil are aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl betaine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; and DMDM hydantoin 0.1 to 5% v/v.

Example 1

(3) 1 ml of TTO and 3 ml of coconut oil are added to 80 ml of glycerol and 16 ml of water to provide 1% v/v TTO and 3% coconut oil v/v in a mixture of glycerol 80% v/v and water 16% v/v.

Example 2

(4) 10 ml of Neem oil and 3 ml of coconut oil are added to 70 ml of glycerol and 17 ml of water to provide 10% v/v Neem oil and 3% coconut oil v/v in a mixture of glycerol 70% v/v and water 13%.

Example 3

(5) 1 ml of TTO, 10 ml of Neem oil; and 3 ml of coconut oil are added to 69 ml of glycerol and 17 ml of water to provide 1% v/v TTO, 10% v/v Neem oil, 3% v/v coconut oil in a mixture of glycerol 69% v/v and water 17% v/v.

Example 4

(6) 1% v/v TTO and 3% coconut oil v/v are combined with aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl betaine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or water or any desired mixture of glycerol and water.

Example 5

(7) 10% v/v Neem oil and 3% coconut oil v/v are combined with aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl betaine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or water or any desired mixture of glycerol and water.

Example 6

(8) 1% v/v TTO, 10% v/v Neem oil, and 3% v/v coconut oil in a mixture of glycerol 69% v/v and water 17% v/v are combined with aloe barbadensis gel, 0.1 to 10% v/v; sodium lauryl sulfate, 0.5 to 5%, w/v; cocoamidopropyl betaine, 0.1 to 5% v/v; lauroyl glucoside 1% to 10% w/v; or DMDM hydantoin 0.1 to 5% v/v, or a combination thereof, in glycerol or water or any desired mixture of glycerol and water.

(9) Formulations and compositions of TTO and/or Neem oil and coconut oil can be used in combination with cleaning towels or cotton tipped applicators for application of the formulation to the eyelid. The formulations and compositions can also be prepared in a foam dispensing bottle having a pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, or a gelling agent, or a combination thereof, and a propellant.

(10) The formulations and compositions of TTO and/or Neem oil and coconut oil provide a method of treating an ocular Demodex-induced blepharitis in the eyelid. The method includes administering to the eyelid a therapeutically-effective amount of a composition having TTO or Neem oil, or a combination thereof, and coconut oil as active agents. The composition is administered topically to the eyelid margin and eyelashes by means of a cleaning towel, a cotton tip applicator, or a foam composition, or a combination thereof. The eyelid margin, eyelashes, and eyelash roots are scrubbed with the composition.

Example 7

(11) A composition having TTO or Neem oil, or a combination thereof, and coconut oil as active agents is provided to a person having Demodex-induced blepharitis in the eyelid. The composition is applied to the eyelid margin and eyelashes. The eyelid margin, eyelashes, and eyelash roots are scrubbed with the composition using any suitable cloth, wipe, sponge, brush, or cotton tipped applicator.

(12) While this invention has been described in some detail with reference to specific exemplary embodiments, there is no intention that the invention be limited to such detail. On the contrary, the invention is intended to include any alternative or equivalent embodiments that fall within the spirit and scope of the invention as described and claimed herein.